@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu40100: (2016-08-06 )
MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDELASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPKVDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKAEVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGPAGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEYDIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGVAYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRLYSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLEGTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIRN
Atome Classification :
(20 SA)
.........10........20........30........40........50..-....---.--.--60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.....---.--.---200.......210.......220.......230.......240.......250.......260.......270.......280.......----290----..----.....300.......310.......320.......330.......340.......350.......360.......370.......380....-...390.......400.......410-.-.-.....420.......430.......440.......450.-.......460.......470.......480.--.--.....490.......500.......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVLD
A
N
I
K
A
Q
L
N
Q
Y
M
Q
L
IEN
D
I
V
L
K
V
SAGEDDT
S
K
D
M
L
A
L
V
D
E
L
A
S
M
S
S
K
I
S
V
-
E
K
A
E---L--N--RTPSFSVNRVGEDT
G
V
T
F
AGIPLG
H
E
F
T
S
L
V
L
A
L
L
QVSGRPPKV
D
Q
K
V
I
D
Q
V
K
K
I
SG
E
Y
H
F
E
S
Y
I
S
L
TCHN
C
P
D
V
V
Q
A
L
N
M
M
S
VLNPNI
T
H
T
MIDG
A
A
Y
K
A
EVESK
N
I
M
A
V
P
T
V
Y
LNGESFGSG
R
M
T
L
E
E
I
L
A
KMGSG---T--
D
---
A
S
E
FADKEP
F
D
V
L
V
VGGGPAGA
S
A
A
I
Y
T
A
RKGIRT
G
V
V
A
E
R
FG
G
Q
V
L
D
T
MSIE
N
F
I
S
V
KATEG
P
K
L
A
A
S
L
E
E
H
V
K
E
YDI
D
V
M
N
L
Q
R
A
K
RL----EKK----D
L
----
F
E
L
ELEN
G
A
V
L
K
S
K
T
V
I
L
STGA
R
W
RNVNVP
G
E
Q
E
F
KNKG
V
A
YCPHCDGPLFEGK
D
V
A
V
IGGGNS
G
I
E
A
A
I
D
L
A
G
I
V
N
H
V
T
V
L
EFAPEL
K
A
D
E
-
V
L
Q
K
R
L
Y
SLP
N
V
T
V
V
KNAQTKEITGD-Q-S-VN
G
I
T
Y
V
DRETGEE
K
H
V
E
L
Q
G
V
F
V
Q
I
G
LVP
N
T
E
W
L
E
G
-
T
-
V
ERNRMG
E
I
I
V
DKHGATSVPG
L
F
AAGDCTDS--
A
--
Y
N
Q
I
I
I
SMGSG
A
T
A
A
L
G
A
F
D
Y
L
IRN---
4
PsiBlast_PDB
84.73
56%
2
- C2 -
4XVG
1
?
A:
[1-517]
-
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
N
S
---
L
--
P
V-
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
G
---
A
--
E
K
R
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
AA
V
E
G
----
G
L
----
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
-
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
-
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
----
1
PsiBlast_PDB
84.70
56%
4
- C2 -
4O5Q
25
AHPF_ECOLI
A:
[1-517]
-
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
N
S
---
L
--
P
V-
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
G
---
A
--
E
KR
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
AA
V
E
G
----
G
L
----
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
-
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
-
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
----
2
PsiBlast_PDB
84.42
56%
3
- C2 -
4O5U
10
AHPF_ECOLI
A:
[1-517]
-
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
N
S
---
L
--
P
V-
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
G
---
A
--
E
K
R
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
G
----
G
L
----
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
-
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
-
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
----
5
PsiBlast_PDB
84.14
56%
2
- C2 -
4YKG
20
AHPF_ECOLI
A:
[1-517]
-
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
N
S
---
L
--
P
V-
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
G
---
A
--
E
KR
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
AA
V
E
G
----
G
L
----
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
-
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
-
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
-
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
----
3
PsiBlast_PDB
83.64
56%
5
- C2 -
4YKF
19
AHPF_ECOLI
A:
[1-517]
-
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
N
S
---
L
--
P
V-
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
G
---
A
--
E
KRA
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
AA
V
E
G
----
G
L
----
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
-
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
-
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
----
120
Fugue
83.16
56%
8
- C2 -
1HYU
4
AHPF_SALTY
A:
[1-521]
-
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
-
K
E
D
N
---
T
--
L
PV
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
T
G
AEK
R
--
A
---
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
----
V
P
A
----
A
T
EG
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
-
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
-
A
-
L
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
KIA
100
HHSearch
83.09
57%
7
- C2 -
1HYU
4
AHPF_SALTY
A:
[1-517]
-
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
-
K
E
D
N
TLP
V
-----
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
T
G
A--
E
K
R
A
---
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
----
V
P
A
ATEG
G
L
----
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
-
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
-
A
-
L
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
----
6
PsiBlast_PDB
82.76
55%
10
- C2 -
1HYU
4
AHPF_SALTY
A:
[1-518]
-
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
-
K
E
D
N
---
T
LP
V
--
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
T
G
---
A
--
E
K
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
AA
T
E
G
----
G
L
----
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
-
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
-
A
-
L
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
---
7
PsiBlast_PDB
66.54
64%
-4
- C2 -
1FL2
5
AHPF_ECOLI
A:
[2-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
AA
V
E
G
----
G
L
----
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
-
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
-
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
---
103
HHSearch
66.44
65%
-4
* C2 *
1FL2
5
AHPF_ECOLI
A:
[1-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
----
I
P
A
AVEG
G
L
----
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
-
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
S
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
-
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
----
23
PsiBlast_CBE
61.29
35%
-94
- C2 -
3F8R
3
?
B:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
----
E
N
R
----
D
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
-
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
-
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
29
PsiBlast_CBE
60.76
35%
-95
- C2 -
3F8D
5
?
B:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
----
E
N
R
----
D
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
-
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
-
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
25
PsiBlast_CBE
60.34
35%
-92
- C2 -
3F8P
1
?
C:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
----
E
N
------
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
-
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
-
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
26
PsiBlast_CBE
60.21
35%
-96
- C2 -
3F8P
4
?
B:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
----
E
-------
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
-
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
-
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
8
PsiBlast_PDB
60.14
35%
-95
- C2 -
3F8P
4
?
A:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
----
E
N
------
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
-
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
-
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
22
PsiBlast_CBE
60.02
35%
-95
- C2 -
3F8R
3
?
C:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
----
E
N
------
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
-
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
-
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
28
PsiBlast_CBE
59.89
35%
-97
- C2 -
3F8D
3
?
C:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
----
E
N
------
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
-
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
-
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
9
PsiBlast_PDB
59.84
35%
-94
- C2 -
3F8R
3
?
A:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
----
E
N
R
-----
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
-
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
-
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
12
PsiBlast_PDB
59.38
35%
-93
- C2 -
3F8D
3
?
A:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
----
E
N
R
-----
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
-
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
-
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
102
HHSearch
57.87
35%
-78
- C2 -
3F8D
3
?
A:
[10-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
P
G
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
-
I
V
E
K
I
----
E
N
R
-----
E
----
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
-
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
-
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
--
W
LG
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
----