@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu40320: (2016-08-07 )
MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAPKIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGVHLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKLL
Atome Classification :
(74 SA)
.........10........20........30........40-----........50...-..--.--..--60..---......70........80........90........100.......110.......120.......130.......140.......150..---.---.-...---160.......170.......180.......190.......200.......210--.--......220.......230.......240.......250.......260.......270.----...----..-----------.280.......290....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDK
T
I
S
V
IGMPM
D
L
G
Q
ARRGVDMG
P
S
A
I
R
Y
A
H
L
I
E
R
L
S
DMG-----Y
T
V
E
D
LGDIPI
N
R
-
E
K--I--K
N
--
D
E
E
L
---
K
N
L
N
S
V
LAG
N
E
K
L
A
Q
K
V
N
K
V
I
E
EKKF
P
L
V
LGGDH
S
I
A
I
G
TLAGTAKHYDN
L
G
V
I
W
Y
DAHGDLNTLETSPSGNIHG
M
P
L
A
V
S
LGIGHE
S
L
VN---L---E-GYA---PKIKPE
N
V
V
I
I
GARSLD
E
G
E
R
K
Y
I
K
ESG
M
K
V
Y
T
M
H
E
I
D
RL
G
M
T
K
V
I
E
E
T
L
D
Y
L
--
S
--ACD
G
V
H
L
S
L
D
LDGLDPNDAPGVGTPVVGG
I
S
Y
R
E
S
H
L
A
M
E
M
L
YDAGII
T
S
A
E
F
V
E
V
NPIL----DHK----NK-----------TG
K
T
A
V
E
L
V
E
S
L
LGKKLL
44
PsiBlast_CBE
87.02
70%
-14
- C7 -
1CEV
2
ARGI_BACCD
C:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
1
PsiBlast_PDB
86.89
70%
-13
- C7 -
1CEV
2
ARGI_BACCD
A:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E
-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
39
PsiBlast_CBE
86.69
70%
-12
- C7 -
2CEV
4
ARGI_BACCD
C:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
24
PsiBlast_CBE
86.67
70%
-11
- C7 -
5CEV
4
ARGI_BACCD
C:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
37
PsiBlast_CBE
86.66
70%
-11
- C7 -
2CEV
3
ARGI_BACCD
E:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
34
PsiBlast_CBE
86.52
70%
-11
- C7 -
3CEV
4
ARGI_BACCD
C:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
3
PsiBlast_PDB
86.50
70%
-11
- C7 -
3CEV
4
ARGI_BACCD
A:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E
-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
36
PsiBlast_CBE
86.48
70%
-10
- C7 -
2CEV
3
ARGI_BACCD
F:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
33
PsiBlast_CBE
86.48
70%
-9
- C7 -
3CEV
4
ARGI_BACCD
D:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
41
PsiBlast_CBE
86.45
70%
-13
- C7 -
1CEV
2
ARGI_BACCD
F:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
42
PsiBlast_CBE
86.42
70%
-15
- C7 -
1CEV
2
ARGI_BACCD
E:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
31
PsiBlast_CBE
86.36
70%
-12
- C7 -
3CEV
4
ARGI_BACCD
F:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
45
PsiBlast_CBE
86.32
70%
-13
- C7 -
1CEV
2
ARGI_BACCD
B:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
40
PsiBlast_CBE
86.32
70%
-14
- C7 -
2CEV
4
ARGI_BACCD
B:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
43
PsiBlast_CBE
86.29
70%
-13
- C7 -
1CEV
2
ARGI_BACCD
D:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
32
PsiBlast_CBE
86.28
70%
-12
- C7 -
3CEV
4
ARGI_BACCD
E:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
21
PsiBlast_CBE
86.15
70%
-11
- C7 -
5CEV
4
ARGI_BACCD
F:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
29
PsiBlast_CBE
86.10
70%
-11
- C7 -
4CEV
4
ARGI_BACCD
C:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
106
HHSearch
86.06
53%
-116
- C7 -
2EF5
5
?
A:
[2-290]
---
R
V
A
V
V
G
V
P
M
D
L
G
-----
V
D
M
G
P
S
A
L
R
Y
A
R
L
L
E
Q
L
E
D
L
G
-----
Y
T
V
E
D
L
G
D
V
P
V
S
L
-
A
------------------
Y
L
E
E
I
R
A
A
A
L
V
L
K
E
R
L
A
A
-
L
P
E
G
V
F
P
I
V
L
G
G
D
H
S
L
S
M
G
S
V
A
G
A
A
R
G
-
R
R
V
G
V
V
W
V
D
A
H
A
D
F
N
T
P
E
T
S
-
S
G
N
V
H
G
M
P
L
A
V
L
S
G
L
G
H
P
R
L
T
E
---
V
-------
F
---
R
A
V
D
P
K
D
V
V
L
V
G
V
R
S
L
D
P
G
E
K
R
L
L
K
E
A
G
V
R
V
Y
T
M
H
E
V
D
R
L
G
V
A
R
I
A
E
E
V
L
K
H
L
-----
Q
G
L
P
L
H
V
S
L
D
A
D
V
L
D
P
T
L
A
P
G
V
G
T
P
V
P
G
G
L
T
Y
R
E
A
H
L
L
M
E
I
L
A
E
S
G
R
V
Q
S
L
D
L
V
E
V
N
P
I
L
----
D
E
R
----
N
R
-----------
T
A
E
M
L
V
G
L
A
L
S
L
L
G
K
R
I
F
27
PsiBlast_CBE
86.02
70%
-12
- C7 -
4CEV
4
ARGI_BACCD
E:
[2-299]
--
K
P
I
S
I
I
G
V
P
M
D
L
G
Q
T
R
R
G
V
D
M
G
P
S
A
M
R
Y
A
G
V
I
E
R
L
E
R
L
H
-----
Y
D
I
E
D
L
G
D
I
P
I
G
K
A
E
R
--
L
HE
Q
G
--
D
S
R
L
---
R
N
L
K
A
V
A
E
A
N
E
K
L
A
A
A
V
D
Q
V
V
Q
R
G
R
F
P
L
V
L
G
G
D
H
S
I
A
I
G
T
L
A
G
V
A
K
H
Y
E
R
L
G
V
I
W
Y
D
A
H
G
D
V
N
T
A
E
T
S
P
S
G
N
I
H
G
M
P
L
A
A
S
L
G
F
G
H
P
A
L
T
Q
---
I
---
G
-
G
Y
S
---
P
K
I
K
P
E
H
V
V
L
I
G
V
R
S
L
D
E
G
E
K
K
F
I
R
E
K
G
I
K
I
Y
T
M
H
E
V
D
R
L
G
M
T
R
V
M
E
E
T
I
A
Y
L
--
K
E-
R
T
D
G
V
H
L
S
L
D
L
D
G
L
D
P
S
D
A
P
G
V
G
T
P
V
I
G
G
L
T
Y
R
E
S
H
L
A
M
E
M
L
A
E
A
Q
I
I
T
S
A
E
F
V
E
V
N
P
I
L
----
D
E
R
----
N
K
-----------
T
A
S
V
A
V
A
L
M
G
S
L
F
G
E
K
L
M
104
HHSearch
72.10
42%
-2
- C7 -
2AEB
3
ARGI1_HUMAN
A:
[5-307]
-
S
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
A
D
-
I
P
N-
D
--
S
P
--
F
Q
I
V
---
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
VPG
F
---
S
-
W
V
T
---
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
----
G
K
T
P
E
E
V
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
L
A
--
103
HHSearch
71.76
34%
-37
- C7 -
3SL1
3
?
A:
[24-405]
--
K
N
V
S
I
I
G
S
P
L
A
A
G
Q
P
L
G
G
V
Q
L
A
C
D
D
L
R
K
L
G
L
H
N
V
I
D
V
L
G
-----
W
K
Y
E
D
I
G
N
I
D
N
----------
C
Y
--
Y
D
N
I
---
R
N
I
K
E
I
G
I
F
S
K
N
L
F
D
T
M
S
N
E
L
R
K
K
N
F
V
L
N
I
G
G
D
H
G
V
A
F
S
S
I
L
S
S
L
Q
M
Y
Q
N
L
R
V
I
W
I
D
A
H
G
D
I
N
I
P
E
T
S
P
S
G
N
Y
H
G
M
T
L
A
H
T
L
G
L
F
K
K
K
V
P
Y
FE-
W
---
S
-
E
N
L
---
T
Y
L
K
P
E
N
T
A
I
I
G
I
R
D
I
D
A
Y
E
K
I
I
L
K
K
C
N
I
N
Y
Y
T
I
F
D
I
E
K
N
G
I
Y
N
T
I
C
T
A
L
E
K
I
--
D
P
N
S
N
C
P
I
H
I
S
L
D
I
D
S
V
D
N
V
F
A
P
G
T
G
T
V
A
K
G
G
L
N
Y
R
E
I
N
L
L
M
K
I
L
A
E
T
K
R
V
V
S
M
D
L
V
E
Y
N
P
S
L
----
D
E
V
----
D
K
KVHGDSLPILD
N
A
T
K
T
G
K
L
C
L
E
L
I
A
----
99
PsiBlast_CBE
71.24
42%
14
- C7 -
4HXQ
3
ARGI1_HUMAN
B:
[2-301]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
92
PsiBlast_CBE
70.84
42%
16
- C7 -
2PLL
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
87
PsiBlast_CBE
70.73
42%
16
- C7 -
3GN0
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
56
PsiBlast_CBE
70.47
42%
12
- C7 -
4GSZ
5
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
62
PsiBlast_CBE
70.39
42%
17
- C7 -
4FCK
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
77
PsiBlast_CBE
70.38
42%
18
- C7 -
3MJL
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
97
PsiBlast_CBE
70.31
42%
15
- C7 -
4IE1
3
ARGI1_HUMAN
B:
[2-301]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
79
PsiBlast_CBE
70.28
42%
16
- C7 -
3MFW
4
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
57
PsiBlast_CBE
70.27
42%
18
- C7 -
4GSV
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
13
PsiBlast_PDB
70.25
42%
18
- C7 -
2PLL
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
75
PsiBlast_CBE
70.17
42%
17
- C7 -
3SJT
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
65
PsiBlast_CBE
70.16
42%
20
- C7 -
3THJ
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
83
PsiBlast_CBE
70.14
42%
16
- C7 -
3LP7
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
88
PsiBlast_CBE
70.01
42%
19
- C7 -
3GMZ
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
76
PsiBlast_CBE
69.97
42%
16
- C7 -
3SJT
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
69
PsiBlast_CBE
69.95
42%
20
- C7 -
3THE
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
20
PsiBlast_PDB
69.94
42%
20
- C7 -
3LP4
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
98
PsiBlast_CBE
69.88
42%
14
- C7 -
4IE1
3
ARGI1_HUMAN
A:
[2-301]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
95
PsiBlast_CBE
69.87
42%
16
- C7 -
2AEB
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
85
PsiBlast_CBE
69.86
42%
18
- C7 -
3LP4
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
82
PsiBlast_CBE
69.85
42%
16
- C7 -
3MFV
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
86
PsiBlast_CBE
69.77
42%
16
- C7 -
3KV2
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
61
PsiBlast_CBE
69.69
42%
16
- C7 -
4FCK
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
16
PsiBlast_PDB
69.69
42%
18
- C7 -
3F80
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
80
PsiBlast_CBE
69.65
42%
17
- C7 -
3MFW
4
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
81
PsiBlast_CBE
69.63
42%
16
- C7 -
3MFV
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
17
PsiBlast_PDB
69.55
42%
18
- C7 -
3KV2
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
55
PsiBlast_CBE
69.44
42%
21
- C7 -
4GSZ
5
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
9
PsiBlast_PDB
69.42
42%
21
- C7 -
1WVA
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
12
PsiBlast_PDB
69.39
42%
16
- C7 -
2PHO
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
100
PsiBlast_CBE
69.36
42%
15
- C7 -
4HXQ
3
ARGI1_HUMAN
A:
[2-301]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
18
PsiBlast_PDB
69.35
42%
18
- C7 -
3GMZ
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
96
PsiBlast_CBE
69.34
42%
19
- C7 -
1WVA
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
102
HHSearch
69.26
39%
17
- C7 -
4HZE
4
ARGI2_HUMAN
A:
[2-297]
---
S
V
A
V
I
G
A
P
F
S
Q
G
Q
K
R
K
G
V
E
H
G
P
A
A
I
R
E
A
G
L
M
K
R
L
S
S
L
G
-----
C
H
L
K
D
F
G
D
L
S
F
T
P
-
V
P
--
K
--
D
D
LY
N
N
L
I
---
V
N
P
R
S
V
G
L
A
N
Q
E
L
A
E
V
V
S
R
A
V
S
D
G
Y
S
C
V
T
L
G
G
D
H
S
L
A
I
G
T
I
S
G
H
A
R
H
C
P
D
L
C
V
V
W
V
D
A
H
A
D
I
N
T
P
L
T
T
S
S
G
N
L
H
G
Q
P
V
S
F
L
L
R
E
L
Q
D
K
V
P
Q
---
L
PGF
S
-
W
I
K
---
P
C
I
S
S
A
S
I
V
Y
I
G
L
R
D
V
D
P
P
E
H
F
I
L
K
N
Y
D
I
Q
Y
F
S
M
R
D
I
D
R
L
G
I
Q
K
V
M
E
R
T
F
D
L
L
I-
G
K-
R
Q
R
P
I
H
L
S
F
D
I
D
A
F
D
P
T
L
A
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
M
Y
I
A
E
E
I
H
N
T
G
L
L
S
A
L
D
L
V
E
V
N
P
Q
L
----
A
T
S
----
E
E
-----------
E
A
K
T
T
A
N
L
A
V
D
V
I
A
----
84
PsiBlast_CBE
69.26
42%
20
- C7 -
3LP7
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
68
PsiBlast_CBE
69.25
42%
17
- C7 -
3THH
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
10
PsiBlast_PDB
69.24
42%
19
- C7 -
2AEB
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
74
PsiBlast_CBE
69.21
42%
18
- C7 -
3SKK
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
89
PsiBlast_CBE
69.20
42%
17
- C7 -
3F80
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
90
PsiBlast_CBE
69.19
42%
19
- C7 -
3DJ8
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
64
PsiBlast_CBE
69.18
42%
17
- C7 -
4FCI
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
70
PsiBlast_CBE
69.16
42%
21
- C7 -
3THE
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
15
PsiBlast_PDB
69.15
42%
20
- C7 -
3DJ8
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
73
PsiBlast_CBE
69.07
42%
21
- C7 -
3SKK
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
51
PsiBlast_CBE
69.07
42%
19
- C7 -
4GWD
4
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
19
PsiBlast_PDB
69.02
42%
19
- C7 -
3GN0
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
67
PsiBlast_CBE
68.97
42%
22
* C7 *
3THH
3
ARGI1_HUMAN
B:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKTP
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
78
PsiBlast_CBE
68.91
42%
16
- C7 -
3MJL
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
52
PsiBlast_CBE
68.71
42%
21
- C7 -
4GWD
4
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
L
G
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
66
PsiBlast_CBE
68.67
42%
19
- C7 -
3THJ
4
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
58
PsiBlast_CBE
68.61
42%
19
- C7 -
4GSV
3
ARGI1_HUMAN
A:
[6-305]
--
R
T
I
G
I
I
G
A
P
F
S
K
G
Q
P
R
G
G
V
E
E
G
P
T
V
L
R
K
A
G
L
L
E
K
L
K
E
Q
E
-----
C
D
V
K
D
Y
G
D
L
P
F
---
A
D
--
I
--
P
N
--
D
S
P
F
QIV
K
N
P
R
S
V
G
K
A
S
E
Q
L
A
G
K
V
A
E
V
K
K
N
G
R
I
S
L
V
L
G
G
D
H
S
L
A
I
G
S
I
S
G
H
A
R
V
H
P
D
L
G
V
I
W
V
D
A
H
T
D
I
N
T
P
L
T
T
T
S
G
N
L
H
G
Q
P
V
S
F
L
L
K
E
L
K
G
K
I
P
D
---
V
---
P
-
G
F
S
WVT
P
C
I
S
A
K
D
I
V
Y
I
G
L
R
D
V
D
P
G
E
H
Y
I
L
K
T
L
G
I
K
Y
F
S
M
T
E
V
D
R
L
G
I
G
K
V
M
E
E
T
L
S
Y
L
LG
R
--
K
K
R
P
I
H
L
S
F
D
V
D
G
L
D
P
S
F
T
P
A
T
G
T
P
V
V
G
G
L
T
Y
R
E
G
L
Y
I
T
E
E
I
Y
K
T
G
L
L
S
G
L
D
I
M
E
V
N
P
S
L
GKT
P
E
E
V
----
T
R
-----------
T
V
N
T
A
V
A
I
T
L
A
C
F
G
----
105
HHSearch
67.20
32%
14
- C7 -
4IU0
4
?
A:
[14-319]
--
K
K
M
S
I
V
L
A
P
F
S
G
G
Q
P
H
S
G
V
E
L
G
P
D
Y
L
L
K
Q
G
L
Q
Q
D
M
E
K
L
G
WD
T
R
L
E
R
V
F
D
G
K
V
V
E
A
R
K
-
A
S
DN
G
--
D
R
--
I
G
R
V
---
K
R
P
R
L
T
A
E
C
T
E
K
I
Y
K
C
V
R
R
V
A
E
Q
G
R
F
P
L
T
I
G
G
D
H
S
I
A
L
G
T
V
A
G
V
L
S
V
H
P
D
A
G
V
I
W
V
D
A
H
A
D
I
N
T
M
S
G
T
V
S
G
N
L
H
G
C
P
L
S
I
L
L
G
L
D
R
E
N
I
P
E
---
C
---
F
S
W
V
P
---
Q
V
L
K
P
N
K
I
A
Y
I
G
L
R
A
V
D
D
E
E
K
K
I
L
H
D
L
N
I
A
A
F
S
M
H
H
V
D
R
Y
G
I
D
K
V
V
S
M
A
I
E
A
V
S
P
K
--
G
T
E
P
V
M
V
S
Y
D
V
D
T
I
D
P
L
Y
V
P
A
T
G
T
P
V
R
G
G
L
S
F
R
E
A
L
F
L
C
E
R
I
A
E
C
G
R
L
V
A
L
D
V
V
E
C
N
P
L
L
----
A
A
T
E
S
H
V
N
D
-----------
T
I
S
V
G
C
A
I
A
R
C
M
M
G
E
T
--