@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu40340: (2016-08-07 )
MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNEYMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEMILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEYKRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAICKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREILGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVIKEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIEKIKHVLRNA
Atome Classification :
(56 SA)
-----.........10........20..-.---.....30........40........50........-60........70.....-...80...--.....90........------100-----.......110.......120.......--130.......140.......150....-...160..-.....170......---------------------.180....-.-.-.------190.......200.......210.......220.......230.......240.......250.......260......---.270--------........280..--.....290.......300.......310.......320......-.---330-.--.......340......----.350--.----.---..--.....----------------------360...-----------....---------.-370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MTAL
S
K
S
K
E
I
I
D
QTSHYGANNYH-P---
L
P
I
V
I
S
E
A
L
G
A
WVKDPEG
N
E
Y
M
D
M
L
S
A
Y
S
A
V
NQGH-R
H
P
K
I
I
Q
A
L
KDQA
D
K
I
T
-
L
T
SRAFHN--DQL
G
P
F
Y
E
K
T
A
KLTG------
K
E
M
-----
I
L
PMNT
G
A
E
A
V
E
S
A
V
K
A
A
R
R
W
A
Y
E
VKG--VADNQ
A
E
I
I
A
C
VGNFHG
R
T
M
L
A
V
SLS
S
-
E
E
E
Y
K
RGF-GPMLPG
I
K
L
IPYG
D
---------------------
V
E
A
L
R
Q
AI-T-P-N------TA
A
F
L
F
EPIQGEA
G
I
V
IPP
E
G
F
L
Q
E
A
A
A
I
CKEE
N
V
L
F
I
A
D
E
I
Q
T
G
LGRTGK
T
F
A
CDWDGIV
P
D
M
Y
I
L
G
K
ALGGGV
F
P
I
S
---
C
I
A---------AD
R
E
I
L
G
V
FNPGS--HGSTFGGNP
L
A
C
A
V
S
I
A
S
L
E
VLEDEKLADRS
L
E
L
G
E
Y
F
K
S
E
L
E
S-I---D
S
--
P
--
V
I
K
E
VRGR
G
L
F
I
G
V
E
L
----
T
E
----
A
----
A
---
R
P
--
Y
C
E
R
L
----------------------
K
-EEG
L
-----------
L
CKE---------T-HD
T
V
I
RFAP
P
L
I
I
SK
E
D
L
D
W
A
I
E
K
I
K
H
V
LRNA
106
HHSearch
93.39
78%
-104
- C1 -
3RUY
-
OAT_BACAN
A:
[11-395]
------------------
T
D
T
Y
G
A
N
N
Y
H
-
P
---
L
P
I
V
I
S
K
A
E
G
V
W
V
E
D
P
E
G
N
R
Y
M
D
L
L
S
A
Y
S
A
V
N
Q
G
H
-
R
H
P
K
I
I
N
A
L
I
D
Q
A
N
R
V
T
-
L
T
S
R
A
F
H
S
--
D
Q
L
G
P
W
Y
E
K
V
A
K
L
T
N
------
K
E
M
-----
V
L
P
M
N
T
G
A
E
A
V
E
T
A
I
K
T
A
R
R
W
A
Y
D
V
K
K
--
V
E
A
N
R
A
E
I
I
V
C
E
D
N
F
H
G
R
T
M
G
A
V
S
M
S
S
-
N
E
E
Y
K
R
G
F
-
G
P
M
L
P
G
I
I
V
I
P
Y
G
D
---------------------
L
E
A
L
K
A
A
I
-
T
-
P
-
N
------
T
A
A
F
I
L
E
P
I
Q
G
E
A
G
I
N
I
P
P
A
G
F
L
K
E
A
L
E
V
C
K
K
E
N
V
L
F
V
A
D
E
I
Q
T
G
L
G
R
T
G
K
V
F
A
C
D
W
D
N
V
T
P
D
M
Y
I
L
G
K
A
L
G
G
G
V
F
P
I
S
---
C
A
A
---------
A
N
R
D
I
L
G
V
F
E
P
G
S
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
S
I
A
A
L
E
V
L
E
E
E
K
L
T
E
R
S
L
Q
L
G
E
K
L
V
G
Q
L
K
E
-
I
---
D
N
--
P
--
M
I
T
E
V
R
G
K
G
L
F
I
G
I
E
L
----
N
E
----
P
----
A
---
R
P
--
Y
C
E
Q
L
----------------------
K
-
A
A
G
L
-----------
L
C
K
E
---------
T
-
H
E
N
V
I
R
I
A
P
P
L
V
I
S
E
E
D
L
E
W
A
F
Q
K
I
K
A
V
L
---
1
PsiBlast_PDB
93.07
76%
-104
- C1 -
3RUY
-
OAT_BACAN
A:
[5-395]
------------
K
D
I
I
E
L
T
D
T
Y
G
A
N
N
Y
H
-
P
---
L
P
I
V
I
S
K
A
E
G
V
W
V
E
D
P
E
G
N
R
Y
M
D
L
L
S
A
Y
S
A
V
N
Q
G
H
-
R
H
P
K
I
I
N
A
L
I
D
Q
A
N
R
V
T
-
L
T
S
R
A
F
H
S
--
D
Q
L
G
P
W
Y
E
K
V
A
K
L
T
N
------
K
E
M
-----
V
L
P
M
N
T
G
A
E
A
V
E
T
A
I
K
T
A
R
R
W
A
Y
D
V
K
K
--
V
E
A
N
R
A
E
I
I
V
C
E
D
N
F
H
G
R
T
M
G
A
V
S
M
S
S
-
N
E
E
Y
K
R
G
F
-
G
P
M
L
P
G
I
I
V
I
P
Y
G
D
---------------------
L
E
A
L
K
A
A
I
-
T
-
P
-
N
------
T
A
A
F
I
L
E
P
I
Q
G
E
A
G
I
N
I
P
P
A
G
F
L
K
E
A
L
E
V
C
K
K
E
N
V
L
F
V
A
D
E
I
Q
T
G
L
G
R
T
G
K
V
F
A
C
D
W
D
N
V
T
P
D
M
Y
I
L
G
K
A
L
G
G
G
V
F
P
I
S
---
C
A
A
---------
A
N
R
D
I
L
G
V
F
E
P
G
S
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
S
I
A
A
L
E
V
L
E
E
E
K
L
T
E
R
S
L
Q
L
G
E
K
L
V
G
Q
L
K
E
-
I
---
D
N
--
P
--
M
I
T
E
V
R
G
K
G
L
F
I
G
I
E
L
----
N
E
----
P
----
A
---
R
P
--
Y
C
E
Q
L
----------------------
K
-
A
A
G
L
-----------
L
C
K
E
---------
T
-
H
E
N
V
I
R
I
A
P
P
L
V
I
S
E
E
D
L
E
W
A
F
Q
K
I
K
A
V
L
---
101
HHSearch
75.13
50%
-38
- C1 -
2OAT
2
OAT_HUMAN
A:
[37-438]
--------
P
P
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
Q
D
-
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
-
3
PsiBlast_PDB
73.66
49%
-40
- C1 -
2OAT
2
OAT_HUMAN
A:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
21
PsiBlast_CBE
72.97
49%
-41
- C1 -
2OAT
1
OAT_HUMAN
C:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
23
PsiBlast_CBE
72.62
49%
-39
- C1 -
1OAT
1
OAT_HUMAN
C:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
22
PsiBlast_CBE
72.46
49%
-42
- C1 -
2OAT
2
OAT_HUMAN
B:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
24
PsiBlast_CBE
72.38
49%
-39
- C1 -
1OAT
2
OAT_HUMAN
B:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
28
PsiBlast_CBE
72.16
49%
-38
- C1 -
1GBN
2
OAT_HUMAN
B:
[3-399]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
2
PsiBlast_PDB
71.94
49%
-39
- C1 -
1OAT
2
OAT_HUMAN
A:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
4
PsiBlast_PDB
71.92
49%
-37
- C1 -
2CAN
2
OAT_HUMAN
A:
[3-399]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
7
PsiBlast_PDB
71.88
48%
-42
- C1 -
2BYL
2
OAT_HUMAN
A:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
A
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
27
PsiBlast_CBE
71.73
49%
-39
- C1 -
1GBN
1
OAT_HUMAN
C:
[3-399]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
31
PsiBlast_CBE
71.50
48%
-41
- C1 -
2BYL
1
OAT_HUMAN
C:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
A
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
25
PsiBlast_CBE
71.41
49%
-38
- C1 -
2CAN
1
OAT_HUMAN
C:
[3-399]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
29
PsiBlast_CBE
71.23
49%
-37
- C1 -
2BYJ
1
OAT_HUMAN
C:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
26
PsiBlast_CBE
71.17
49%
-38
- C1 -
2CAN
2
OAT_HUMAN
B:
[3-399]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
5
PsiBlast_PDB
71.06
49%
-39
- C1 -
1GBN
2
OAT_HUMAN
A:
[3-399]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
32
PsiBlast_CBE
70.93
48%
-42
- C1 -
2BYL
2
OAT_HUMAN
B:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
A
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
6
PsiBlast_PDB
70.83
49%
-39
- C1 -
2BYJ
2
OAT_HUMAN
A:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
14
PsiBlast_PDB
70.64
49%
-38
- C1 -
5EQC
7
?
A:
[43-428]
--------------------
Q
Y
V
C
Q
N
Y
A
-
P
---
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
-
L
T
L
R
A
F
G
N
--
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
------
Y
D
R
-----
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
--
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
-
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
------
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
P
I
S
---
A
V
M
---------
G
R
A
D
V
M
D
V
L
K
P
G
T
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
-
E
LYG
K
V
--
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D---
S
D
----
A
----
I
---
D
P
N
D
V
V
M
K
L
----------------------
K
-
E
N
G
I
-----------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
-------
103
HHSearch
70.56
48%
-33
- C1 -
4NOG
3
?
A:
[18-419]
----------
T
E
E
D
F
F
A
C
D
R
Q
Y
V
C
Q
N
Y
A
-
P
---
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
-
L
T
L
R
A
F
G
N
--
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
------
Y
D
R
-----
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
--
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
-
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
------
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
P
I
S
---
A
V
M
---------
G
R
A
D
V
M
D
V
L
K
P
G
T
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
---
Y
G
KV
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S
DAI-
D
----
P
---
N
D
--
V
V
M
K
L
----------------------
K
-
E
N
G
I
-----------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
K
S
F
L
A
-
30
PsiBlast_CBE
70.56
49%
-39
- C1 -
2BYJ
2
OAT_HUMAN
B:
[40-436]
-----------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
-
L
T
S
R
A
F
Y
N
--
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
------
Y
H
K
-----
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
--
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
D
P
-
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
G
E
--
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
---
39
PsiBlast_CBE
69.77
49%
-38
- C1 -
4ZWM
10
?
B:
[43-428]
--------------------
Q
Y
V
C
Q
N
Y
A
-----
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
-
L
T
L
R
A
F
G
N
--
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
------
Y
D
R
-----
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
--
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
-
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
------
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
P
I
S
---
A
V
M
---------
G
R
A
D
V
M
D
V
L
K
P
G
T
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
-
E
LYG
K
V
--
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D---
S
D
----
A
----
I
---
D
P
N
D
V
V
M
K
L
----------------------
K
-
E
N
G
I
-----------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
-------
40
PsiBlast_CBE
69.02
49%
-36
- C1 -
4ZLV
6
?
B:
[43-428]
--------------------
Q
Y
V
C
Q
N
Y
A
-
P
---
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
-
L
T
L
R
A
F
G
N
--
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
------
Y
D
R
-----
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
--
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
-
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
------
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
P
I
S
---
A
V
M
---------
G
R
A
D
V
M
D
V
L
K
P
G
T
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
-
E
LYG
K
V
--
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D---
S
D
----
A
----
I
---
D
P
ND
V
V
M
K
L
----------------------
K
-
E
N
G
I
-----------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
-------
10
PsiBlast_PDB
68.44
49%
-36
- C1 -
4NOG
3
?
A:
[28-413]
--------------------
Q
Y
V
C
Q
N
Y
A
-
P
---
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
-
L
T
L
R
A
F
G
N
--
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
------
Y
D
R
-----
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
--
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
-
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
------
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
P
I
S
---
A
V
M
---------
G
R
A
D
V
M
D
V
L
K
P
G
T
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
-
E
LYG
K
V
--
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D---
S
D
----
A
----
I
---
D
P
N
D
V
V
M
K
L
----------------------
K
-
E
N
G
I
-----------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
-------
11
PsiBlast_PDB
68.27
49%
-35
- C1 -
4ZLV
5
?
A:
[43-428]
--------------------
Q
Y
V
C
Q
N
Y
A
-
P
---
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
-
L
T
L
R
A
F
G
N
--
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
------
Y
D
R
-----
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
--
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
-
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
------
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
P
I
S
---
A
V
M
---------
G
R
A
D
V
M
D
V
L
K
P
G
T
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
-
E
LYG
K
V
--
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D---
S
D
----
A
----
I
---
D
P
N
D
V
V
M
K
L
----------------------
K
-
E
N
G
I
-----------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
-------
37
PsiBlast_CBE
68.03
49%
-35
- C1 -
5EQC
8
?
B:
[43-428]
--------------------
Q
Y
V
C
Q
N
Y
A
------
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
-
L
T
L
R
A
F
G
N
--
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
------
Y
D
R
-----
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
--
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
-
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
------
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
P
I
S
---
A
V
M
---------
G
R
A
D
V
M
D
V
L
K
P
G
T
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
-
E
LYG
K
V
--
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D---
S
D
----
A
----
I
---
D
P
N
D
V
V
M
K
L
----------------------
K
-
E
N
G
I
-----------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
-------
36
PsiBlast_CBE
68.02
49%
-36
- C1 -
4NOG
6
?
B:
[28-413]
--------------------
Q
Y
V
C
Q
N
Y
A
-
P
---
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
-
L
T
L
R
A
F
G
N
--
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
------
Y
D
R
-----
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
--
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
-
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
------
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
P
I
S
---
A
V
M
---------
G
R
A
D
V
M
D
V
L
K
P
G
T
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
-
E
LYG
K
V
--
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D---
S
D
----
A
----
I
---
D
P
N
D
V
V
M
K
L
----------------------
K
-
E
N
G
I
-----------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
-------
12
PsiBlast_PDB
67.66
49%
-38
- C1 -
4ZWM
12
?
A:
[43-428]
--------------------
Q
Y
V
C
Q
N
Y
A
-----
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
-
L
T
L
R
A
F
G
N
--
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
------
Y
D
R
-----
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
--
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
-
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
------
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
P
I
S
---
A
V
M
---------
G
R
A
D
V
M
D
V
L
K
P
G
T
--
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
-
E
LYG
K
V
--
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D---
S
D
----
A
----
I
---
D
P
N
D
V
V
M
K
L
----------------------
K
-
E
N
G
I
-----------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
-------
20
PsiBlast_PDB
64.18
36%
-72
- C1 -
2E54
5
ARGD_THEMA
A:
[2-383]
---------------------
Y
L
M
N
T
Y
S
-
R
---
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
-
H
C
S
N
L
F
W
N
--
R
P
Q
M
E
L
A
E
L
L
S
K
N
T
F
------
G
G
K
-----
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
---
K
K
--
K
S
E
K
K
Y
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
-
Q
P
K
Y
Q
K
P
F
-
E
P
L
V
P
G
F
E
Y
F
E
F
N
N
---------------------
V
E
D
L
R
R
K
M
-
S
-
E
-
D
------
V
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
V
-
P
I
G
---
A
V
I
---------
V
N
-
E
R
A
N
V
L
E
P
G
D
--
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
-
M
K
E
-
E
Y
--
D
--
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
----
R
E
EV--
S
----
N
---
R
E
--
V
A
T
K
C
----------------------
F
-
E
N
K
L
-----------
L
V
V
P
---------
A
-
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
--
121
Fugue
63.01
44%
19
- C1 -
2OAT
2
OAT_HUMAN
A:
[36-439]
GPPT
S
D
--
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
-----
H
-
P
---
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
-
S
Q
V
D
K
L
---
T
L
T
S
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
-
Y
I
------
T
K
L
F
NYH
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
IQ--
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
-
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
E
R
A
L
-
Q
-
D
P
N
------
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
---
A
V
L
---------
C
D
D
D
I
M
L
T
I
K
P
--GE
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
-
L
---
P
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
K
--
V
C
L
R
L
----------------------
R
-
D
N
G
L
-----------
L
A
K
P
---------
T
H-
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
104
HHSearch
62.64
35%
-64
- C1 -
4JF1
9
ARGD_SALTY
A:
[36-417]
--------------------------
Y
A
-
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
---
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
--------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
Q
F
D
--
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
KYKG
R
----
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
-
65
PsiBlast_CBE
60.69
34%
-66
- C1 -
4JEY
13
ARGD_SALTY
B:
[36-411]
--------------------------
Y
A
-
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
H
V
G
S
--
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
52
PsiBlast_CBE
60.61
34%
-67
- C1 -
2PB0
5
ARGD_SALTY
A:
[36-411]
--------------------------
Y
A
-
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
-------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
47
PsiBlast_CBE
59.77
34%
-66
- C1 -
4JEW
13
ARGD_SALTY
B:
[36-411]
--------------------------
Y
A
-
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
H
V
G
S
--
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
48
PsiBlast_CBE
59.74
34%
-69
- C1 -
4JEW
12
ARGD_SALTY
A:
[36-411]
--------------------------
Y
A
-
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
-------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
51
PsiBlast_CBE
59.55
34%
-65
- C1 -
2PB0
5
ARGD_SALTY
B:
[36-411]
--------------------------
Y
A
-
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
H
V
G
S
--
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
53
PsiBlast_CBE
59.44
34%
-63
- C1 -
4JF1
9
ARGD_SALTY
B:
[36-411]
--------------------------
Y
A
-
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
H
V
G
S
--
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
55
PsiBlast_CBE
59.40
34%
-68
- C1 -
4JEX
17
ARGD_SALTY
B:
[38-411]
-----------------------------
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
-------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
50
PsiBlast_CBE
59.10
34%
-69
- C1 -
2PB2
6
ARGD_SALTY
A:
[39-411]
---------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
54
PsiBlast_CBE
57.92
34%
-68
- C1 -
4JF1
9
ARGD_SALTY
A:
[36-411]
--------------------------
Y
A
-
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
--------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
46
PsiBlast_CBE
57.77
35%
-68
- C1 -
4JEZ
14
ARGD_SALTY
A:
[39-411]
---------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
R
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
-------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
56
PsiBlast_CBE
57.75
34%
-69
- C1 -
4JEX
17
ARGD_SALTY
A:
[39-411]
---------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
N
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
-------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
45
PsiBlast_CBE
57.62
35%
-66
- C1 -
4JEZ
13
ARGD_SALTY
B:
[36-411]
--------------------------
Y
A
-
P
---
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
-
H
T
S
R
V
F
T
N
--
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
------
A
E
R
-----
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
----
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
------
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
---
A
M
L
---------
T
T
Q
E
I
A
S
A
F
-------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
-
I
---
D
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
D
--
F
L
Y
A
G
----------------------
A
-
E
A
G
V
-----------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
16
PsiBlast_PDB
56.53
42%
15
- C1 -
1VEF
2
ARGD_THET8
A:
[16-394]
----------------
E
K
T
L
D
S
G
V
Y
N
K
H
-
D
---
L
L
I
V
R
G
Q
--
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
-
A
M
P
Q
T
L
P
T
--
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
------
P
E
L
N
R
---
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
----------
A
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
------
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
-
P
L
G
---
V
A
V
---------
M
R
E
E
V
A
R
S
M
P
K
G
G
--
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
-
I
---
P
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
P
--
Y
I
A
R
L
E
---------------------
K
-
E
H
R
V
-----------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
43
PsiBlast_CBE
55.43
42%
17
- C1 -
1VEF
2
ARGD_THET8
B:
[16-394]
----------------
E
K
T
L
D
S
G
V
Y
N
K
H
-
D
---
L
L
I
V
R
G
Q
--
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
-
A
M
P
Q
T
L
P
T
--
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
------
P
E
L
NR---
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
----------
A
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
------
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
-
P
L
G
---
V
A
V
---------
M
R
E
E
V
A
R
S
M
P
K
G
G
--
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
-
I
---
P
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
P
--
Y
I
A
R
L
E---------------------
K
-
E
H
R
V
-----------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
42
PsiBlast_CBE
54.89
42%
17
- C1 -
1WKG
2
ARGD_THET8
B:
[16-394]
----------------
E
K
T
L
D
S
G
V
Y
N
K
H
-
D
---
L
L
I
V
R
G
Q
--
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
-
A
M
P
Q
T
L
P
T
--
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
------
P
E
L
NR---
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
----------
A
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
------
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
-
P
L
G
---
V
A
V
---------
M
R
E
E
V
A
R
S
M
P
K
G
G
--
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
-
I
---
P
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
P
--
Y
I
A
R
L
E---------------------
K
-
E
H
R
V
-----------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
120
HHSearch
53.19
36%
4
- C1 -
2ORD
15
ARGD_THEMA
A:
[9-396]
-----------------
H
H
H
H
M
Y
L
M
N
T
Y
S
R
---
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
-
H
C
S
N
L
F
W
N
--
R
P
Q
M
E
L
A
E
L
L
S
K
N
T
F
------
G
G
K
-----
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
K
K
-
K
----
S
E
K
K
Y
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
-
Q
P
K
Y
Q
K
P
F
-
E
P
L
V
P
G
F
E
Y
F
E
F
N
N
---------------------
V
E
D
L
R
R
K
M
-
S
-
E
-
D
------
V
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
V
-
P
I
G
---
A
V
I
---------
V
N
E
R
A
N
-
V
L
E
P
G
D
--
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
-
M
---
K
E
E
Y
D
--
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
----
R
E
EV--
S
----
N
---
R
E
--
V
A
T
K
C
----------------------
F
-
E
N
K
L
-----------
L
V
V
P
---------
A
-
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
-
17
PsiBlast_PDB
53.09
42%
16
- C1 -
1WKG
2
ARGD_THET8
A:
[16-394]
----------------
E
K
T
L
D
S
G
V
Y
N
K
H
-
D
---
L
L
I
V
R
G
Q
--
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
-
A
M
P
Q
T
L
P
T
--
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
------
P
E
L
N
R
---
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
----------
A
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
------
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
-
P
L
G
---
V
A
V
---------
M
R
E
E
V
A
R
S
M
P
K
G
G
--
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
-
I
---
P
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
P
--
Y
I
A
R
L
E
---------------------
K
-
E
H
R
V
-----------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
44
PsiBlast_CBE
52.84
39%
34
- C1 -
2EH6
2
ARGD_AQUAE
B:
[2-375]
---------------------
Y
L
M
N
N
Y
A
-
R
---
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
-
H
V
S
N
L
Y
E
N
------
P
W
Q
E
E
L
A
H
K
L
V
------
K
H
F
WTEGK
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
-
W
R
D
K
G
----
K
N
K
W
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
-
Q
P
K
F
H
K
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
L
N
D
---------------------
I
D
S
V
Y
K
L
L
-
D
-
E
-
E
------
T
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
V
-
P
I
G
---
A
I
L
---------
A
R
E
E
V
A
Q
S
F
T
P
G
S
--
H
G
S
T
F
G
G
N
P
L
A
C
R
A
--
G
T
V
V
V
D
E
V
E
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
-
L
---
G
K
--
G
-----
K
V
K
G
R
G
L
M
L
G
L
E
L
----
E
R
----
E
----
C
---
K
D
--
Y
V
L
K
A
----------------------
L
-
E
K
G
L
-----------
L
I
N
C
---------
T
-
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
---
111
HHSearch
52.49
41%
15
- C1 -
1VEF
2
ARGD_THET8
A:
[9-394]
-----------
W
R
A
L
L
E
A
E
K
T
L
D
S
G
V
Y
N
-
K
---
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
-
A
M
P
Q
T
L
P
T
--
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
PE----
L
N
R
-----
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
----------
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
------
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
-
P
L
G
---
V
A
V
---------
M
R
E
E
V
A
R
S
M
P
K
G
G
--
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
-
I
---
P
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
P
--
Y
I
A
R
L
----------------------
E
K
E
H
R
V
-----------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
19
PsiBlast_PDB
49.75
39%
37
- C1 -
2EH6
2
ARGD_AQUAE
A:
[2-375]
---------------------
Y
L
M
N
N
Y
A
-
R
---
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
-
H
V
S
N
L
Y
E
N
------
P
W
Q
E
E
L
A
H
K
L
V
------
K
H
F
W
T
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
-
W
R
D
K
G
----
K
N
K
W
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
-
Q
P
K
F
H
K
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
L
N
D
---------------------
I
D
S
V
Y
K
L
L
-
D
-
E
-
E
------
T
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
V
-
P
I
G
---
A
I
L
---------
A
R
E
E
V
A
Q
S
F
T
P
G
S
--
H
G
S
T
F
G
G
N
P
L
A
C
R
A
--
G
T
V
V
V
D
E
V
E
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
-
L
---
G
K
--
G
-----
K
V
K
G
R
G
L
M
L
G
L
E
L
----
E
R
----
E
----
C
---
K
D
--
Y
V
L
K
A
----------------------
L
-
E
K
G
L
-----------
L
I
N
C
---------
T
-
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
---
81
PsiBlast_CBE
41.48
32%
2
- C1 -
2EO5
3
?
A:
[3-416]
-----------
S
R
K
I
I
E
E
S
D
I
Y
L
A
T
S
T
R
-
D
PEL
F
P
L
V
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
Q
M
Q
K
L
A
H
A
A
A
N
D
F
Y
N
--
I
---
P
Q
L
E
L
A
K
K
L
V
T
Y
SPGN
F
Q
K
K
-----
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
-----------
T
G
R
K
Y
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
-
S
K
A
V
Q
R
S
I
V
G
P
F
M
P
G
V
I
H
V
P
Y
P
N
PYRNPWHINGYEN
P
S
E
L
V
N
R
V
I
E
F
I
E
D
Y
I
-
F
-
V
-
N
LVPPEE
V
A
G
I
F
F
E
P
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
P
I
G
---
A
T
I
---------
F
R
K
D
L
--
D
F
K
--------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
D
--
L
L
P
H
V
N
E
I
G
K
I
F
A
E
E
L
Q
G
-
L
---
A
D
--------
D
V
R
G
I
G
L
A
W
G
L
E
Y
----
N
E
----
K
----
K
V
R
D
R
I
--
I
G
E
S
F
----------------------
K
--
R
G
L
-----------
L
L
L
P
---------
A
-
G
R
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
K
--
79
PsiBlast_CBE
30.75
32%
22
- C1 -
4PPM
3
?
B:
[418-835]
------------------------------------
V
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
Y
L
D
A
Q
G
-
P
N
F
I
Q
Y
I
S
IP
E
Q
T
A
K
L
A
E
V
L
C
R
L
A
P
------
G
N
M
GR---
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
----------
A
S
T
G
K
P
G
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
-
R
D
K
H
R
R
Y
F
-
T
P
L
L
D
A
M
V
E
V
P
F
G
D
---------------------
L
A
A
L
R
E
A
L
-
N
R
E
-
D
------
V
G
A
L
M
I
E
P
I
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
L
I
P
I
G
ATL
C
R
A
DLWQKAYGT
A
D
R
F
L
V
---------
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
K
Q
A
L
S
E
-
I
---
A
A
RY
P
--
F
V
S
E
V
R
G
R
G
L
M
L
G
I
Q
F
----
D
-----------------------WHTTWKFLPDPVQAHLRAAMDR
M
-
E
Q
A
L
GEMFCMKFVTK
L
C
Q
D
HKILTFITA
N
-
S
S
T
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
-------------
80
PsiBlast_CBE
30.35
32%
19
- C1 -
4PPM
3
?
A:
[418-835]
------------------------------------
V
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
Y
L
D
A
Q
G
-
P
N
F
I
Q
Y
I
S
IP
E
Q
T
A
K
L
A
E
V
L
C
R
L
A
P
------
G
N
M
G
R
---
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
----------
A
S
T
G
K
P
G
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
-
R
D
K
H
R
R
Y
F
-
T
P
L
L
D
A
M
V
E
V
P
F
G
D
---------------------
L
A
A
L
R
E
A
L
-
N
R
E
-
D
------
V
G
A
L
M
I
E
P
I
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
L
I
P
I
G
A
T
L
C
R
A
D
L
W
Q
K
A
YGT
A
D
R
F
L
V
---------
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
K
Q
A
L
S
E
-
I
---
A
A
R
Y
P
--
F
V
S
E
V
R
G
R
G
L
M
L
G
I
Q
F
----
D
Q
----
A
-----------------H
T
T
W
K
F
LP
D
P
V
Q
A
H
L
R
A
A
M
D
R
-
M
-
E
Q
A
L
G
E
M
F
C
M
K
F
V
T
K
L
C
Q
D
HK
I
L
T
F
I
T
A
N
-
S
S
T
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
-------------