@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu40930: (2016-08-08 )
MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKICGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLHSHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNSKHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGWLAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAGLYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAKTKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEKVPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKSDSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPWDDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQRSNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAKTINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA
Atome Classification :
(20 SA)
.........10........20...---..-------------------------------------------..-.30---.....-..-.40........50.......-----.60....------..-------------.---------------.---------------70--.--.......80........90........100.-...--.------.--..110.---...---...120.....--...130.------........140.......--150----.-----..---.....-----------.160.......170-..-.--------..---------.--------.180--.---------------..-.--..----..190.......200..-.--.--------....210.......220.......230.......240.---------......250--------.------......260.......270.......-280-----.........290.......300.......310--...--.....-----------------------320-----------.....---------------..-.-.330-.------.------....---..340------------.-.---------.--------------.-------.....--------------------------350---........------------360-..-----------.----.-....370.......380....------------------------------...390.-......400...-....410.......420-......---.430..-....----.440.......450.......460....-------------...--470-.----.------.....480.-----.--------------....------.490-......-.--.-.500.-------...-----------.---..----------.--------510-..-------..---------------.....520.......530...----....540...--....550-----.........560.-......570---.......-----.----580...------....590.......600.......610.......620.......630....------------------...-640.....-..650........-660.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSKVHQSACPLNCWDSC
G
F
L
V
T
VD---DG-------------------------------------------
K
V
-
T
KV---DGDPN-HP-ITEGKICGRG
R
M
L
ETKTNS
P
-----
D
RLRYPM------KK-------------Q---------------N---------------G
E
--
F
--
V
R
I
S
W
E
Q
A
L
D
E
I
A
D
K
L
R
E
I
K
E
TSE
T
T
A
V
-
L
H-SHD--Y------A--NN
G
L
L
K
---
A
L
D
---
Q
R
F
FN-GYG
G
V
--
T
E
I
V
--
G
------
S
I
CWGSGIEAQSWDFGRS--Y------G-----HG---P
L
D
IY-----------NS
K
H
V
V
V
WGRNVS
R
-
T
N
-
M
--------
H
L
---------
Y
--------
H
H
L
---
Q
---------------
Q
V
-
K
--KK----G
A
T
I
T
V
IDPIFN
P
T
-
A
K
-
L
--
A
--------
D
R
Y
I
SVKPGM
D
G
W
L
A
A
A
V
L
K
V
L
I
EMGRTD
E
T
F
I
S
EHSV---------
G
F
D
D
V
K
E
L
L
--------
K
------
T
V
S
L
E
E
F
I
V
KTET
S
M
E
E
L
E
Y
L
A
G
LYA-D-------G
P
V
S
T
F
M
G
L
G
M
Q
R
YKNGG
G
T
I
R
W
I
D
A
L
V
AAS---GNV--
G
I
KGG-----------------------G-------------ANFGN---------------
V
Q
-I-G
E
S
--
F
------
A
------KTKL---TLP--------------E-L---------K--------------T-------TS
R
S
F
--------------------------
S
M
----
M
T
Q
A
E
E
V
L
------------T-A-AD-----------P----
A
-
I
E
M
I
I
V
TCGNPLTQVPN
T
N
K
V
------------------------------
R
Q
A
F
E
KV-P
M
T
V
A
I
D
S
I
M
T
D
-
T
A
E
L
C
D
Y
VLPTATVFEE-ED
I
Y
Y
S
---
S
M
Y
H
H
Y
-
V
Q
Y
G
----
K
K
LVEPQGEAKSD
S
W
I
W
S
E
L
A
K
RLG
F
G
E
-------------
L
F
E
--
Y
S
T
-
Q
----
E
------
F
L
E
M
G
L
S
SL-----E--------------AE
D
V
------
T
L
---
E
R
L
K
EK-G--H-LP-LP-------VKQ-----------V---PW----------D--------D---
Y
Q
-------
F
L---------------TPSGK
F
E
F
T
S
S
L
A
EQKGFSG
S
----
L
Q
L
NVP
E
E
SV--FHNEE-------LAGKY
P
Y
T
L
L
S
IH-PQRSNHSQ----H
V
P
F
I
E
K
-----
L
----
Q
H
V
Q
V
D------ISPDIAAGQDLQDG
D
E
V
V
I
FNDRGSMK
G
K
V
K
V
M
K
Q
AH
A
K
TINIDE
G
M
W
A
AF------------------GGS-
V
N
ALTNDT-NSDN-G
M
G
S
T
L
F
D
-
C
L
VGLKKA
11
PsiBlast_PDB
75.99
24%
19
- C1 -
3DMR
5
DSTOR_RHOCA
A:
[59-760]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
---
T
P
W
E
K
-
D
P
-
H
P
S
P
M
L
A
G
---
V
L
D
S
-
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
-
G
--------
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
D
GETDSTP
K
------
T
A
E
W
A
E
G
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
F
G
LSYHYSGGGTP
S
T
S
G
P
---------------
A
L
-
A
-
G
I
T
--
D
------
G
------
G
A
A
T
---
K
G
P
--------------
E
W
L
---------
A
--------------
A
-------
S
G
A
S
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
-------------
E
F
T
--
E
G
K
-
D
----
E
M
G
W
I
K
S
F
Y
D
D
A
A
K
Q
G
-----
K
--------------
A
A
G
V
------
Q
M
P
A
F
D
A
F
W
A
E
-
G
--
I
-
V
E
-
F
P
-------
V
T
D
GADF-------
V
---
R
Y
----------
A
--------
S
---
F
R
E
DPLLNP
L
G
---------------
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
EGYAV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
6
PsiBlast_PDB
75.55
24%
23
- C1 -
1E18
6
DSTOR_RHOCA
A:
[59-760]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
---
T
P
W
E
K
-
D
P
-
H
P
S
P
M
L
A
G
---
V
L
D
S
-
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
Q
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
-
G
--------
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
D
GETDSTP
K
------
T
A
E
W
A
E
G
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
F
G
LSYHYSGGGTP
S
T
S
G
P
---------------
A
L
-
A
-
G
I
T
--
D
------
G
------
G
A
A
T
---
K
G
P
--------------
E
W
L
---------
A
--------------
A
-------
S
G
A
S
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
K
-------------
E
F
T
--
E
G
K
-
D
----
E
M
G
W
I
K
S
F
Y
D
D
A
A
K
Q
G
-----
K
--------------
A
A
G
V
------
E
M
P
A
F
D
A
F
W
A
E
-
G
--
I
-
V
E
-
F
P
-------
V
T
D
GADF-------
V
---
R
Y
----------
A
--------
S
---
F
R
E
DPLLNP
L
G
---------------
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
E
G
YAV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
12
PsiBlast_PDB
75.45
24%
20
- C1 -
1E60
5
DSTOR_RHOCA
A:
[59-760]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
---
T
P
W
E
K
-
D
P
-
H
P
S
P
M
L
A
G
---
V
L
D
S
-
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
-
G
--------
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
D
GETDSTP
K
------
T
A
E
W
A
E
G
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
FGLSYHYSGGGTP
S
T
S
G
P
---------------
A
L
-
A
-
G
I
T
--
D
------
G
------
G
A
A
T
---
K
G
P
--------------
E
W
L
---------
A
--------------
A
-------
S
G
A
S
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
-------------
E
F
T
--
E
G
K
-
D
----
E
M
G
W
I
K
S
F
Y
D
D
A
A
K
Q
G
-----
K
--------------
A
A
G
V
------
E
M
PA
F
D
A
F
W
A
E
-
G
--
I
-
V
E
-
F
P
-------
V
T
D
GADF-------
V
---
R
Y
----------
A
--------
S
---
F
R
E
DPLLNP
L
G
---------------
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
E
G
YAV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
9
PsiBlast_PDB
75.36
24%
21
- C1 -
1DMR
5
DSTOR_RHOCA
A:
[59-760]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
---
T
P
W
E
K
-
D
P
-
H
P
S
P
M
L
A
G
---
V
L
D
S
-
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
-
G
--------
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
D
GETDSTP
K
------
T
A
E
W
A
E
G
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
F
G
LSYHYSGGGTP
S
T
S
G
P
---------------
A
L
-
A
-
G
I
T
--
D
------
G
------
G
A
A
T
---
K
G
P
--------------
E
W
L
---------
A
--------------
A
-------
S
G
A
S
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
-------------
E
F
T
--
E
G
K
-
D
----
E
M
G
W
I
K
S
F
Y
D
D
A
A
K
Q
G
-----
K
--------------
A
A
G
V
------
Q
M
P
A
F
D
A
F
W
A
E
-
G
--
I
-
V
E
-
F
P
-------
V
T
D
GADF-------
V
---
R
Y
----------
A
--------
S
---
F
R
E
DPLLNP
L
G
---------------
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
EGYAV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
8
PsiBlast_PDB
74.55
24%
20
- C1 -
1H5N
4
DSTOR_RHOCA
A:
[59-760]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
---
T
P
W
E
K
-
D
P
-
H
P
S
P
M
L
A
G
---
V
L
D
S
-
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
-
G
--------
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
D
GETDSTP
K
------
T
A
E
W
A
E
G
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
F
G
LSYHYSGGGTP
S
T
S
G
P
---------------
A
L
-
A
-
G
I
T
--
D
------
G
------------------------------------------------------------------
G
A
S
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
-------------
E
F
T
--
E
G
K
-
D
----
E
M
G
W
I
K
S
F
Y
D
D
A
A
K
Q
G
-----
K
--------------
A
A
G
V
------
Q
M
P
A
F
D
A
F
W
A
E
-
G
--
I
-
V
E
-
F
P
-------
V
T
D
GADF-------
V
---
R
Y
----------
A
--------
S
---
F
R
E
DPLLNP
L
G
---------------
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
E
G
Y
AV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
10
PsiBlast_PDB
74.34
24%
22
- C1 -
2DMR
5
DSTOR_RHOCA
A:
[59-760]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
---
T
P
W
E
K
-
D
P
-
H
P
S
P
M
L
A
G
---
V
L
D
S
-
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
-
G
--------
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
D
GETDSTP
K
------
T
A
E
W
A
E
G
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
F
G
LSYHYSGGGTP
S
T
S
G
P
---------------
A
L
-
A
-
G
I
T
--
D
------
G
------
G
A
A
T
---
K
G
----------------------------------------------------
A
S
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
-------------
E
F
T
--
E
G
K
-
D
----
E
M
G
W
I
K
S
F
Y
D
D
A
A
K
Q
G
-----
K
--------------
A
A
G
V
------
Q
M
P
A
F
D
A
F
W
A
E
-
G
--
I
-
V
E
-
F
P
-------
V
T
D
GADF-------
V
---
R
Y
----------
A
--------
S
---
F
R
E
DPLLNP
L
G
---------------
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
EGYAV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
5
PsiBlast_PDB
74.25
24%
24
- C1 -
4DMR
5
DSTOR_RHOCA
A:
[59-760]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
---
T
P
W
E
K
-
D
P
-
H
P
S
P
M
L
A
G
---
V
L
D
S
-
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
S
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
-
G
--------
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
D
GETDSTP
K
------
T
A
E
W
A
E
G
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
F
G
LSYHYSGGGTP
S
T
S
G
P
---------------
A
L
-
A
-
G
I
T
--
D
------
G
------
G
------
K
G
P
--------------
E
W
L
---------
A
--------------
A
-------
S
---
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
-------------
E
F
T
--
E
G
K
-
D
----
E
M
G
W
I
K
S
F
Y
D
D
A
A
K
Q
G
-----
K
--------------
A
A
G
V
------
Q
M
P
A
F
D
A
F
W
A
E
-
G
--
I
-
V
E
-
F
P
-------
V
T
D
GADF-------
V
---
R
Y
----------
A
--------
S
---
F
R
E
DPLLNP
L
G
---------------
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
EGYAV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
7
PsiBlast_PDB
74.20
24%
19
- C1 -
1E5V
4
DSTOR_RHOCA
A:
[59-760]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
---
T
P
W
E
K
-
D
P
-
H
P
S
P
M
L
A
G
---
V
L
D
S
-
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
-
G
--------
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
D
GETDSTP
K
------
T
A
E
W
A
E
G
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
F
G
LSYHYSGGGTP
S
T
S
G
P
---------------
A
L
-
A
-
G
I
T
--
D
------
G
------------------------------------------------------------------
G
A
S
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
-------------
E
F
T
--
E
G
K
-
D
----
E
M
G
W
I
K
S
F
Y
D
D
A
A
K
Q
G
-----
K
--------------
A
A
G
V
------
Q
M
P
A
F
D
A
F
W
A
E
-
G
--
I
-
V
E
-
F
P
-------
V
T
D
GADF-------
V
---
R
Y
----------
A
--------
S
---
F
R
E
DPLLNP
L
G
---------------
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
EGYAV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
13
PsiBlast_PDB
74.12
24%
21
- C1 -
1E61
4
DSTOR_RHOCA
A:
[59-760]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
---
T
P
W
E
K
-
D
P
-
H
P
S
P
M
L
A
G
---
V
L
D
S
-
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
-
G
--------
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
D
GETDSTP
K
------
T
A
E
W
A
E
G
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
F
G
LSYHYSGGGTP
S
T
S
G
P
---------------
A
L
-
A
-
G
I
T
--
D
------
G
------
G
-----------------------------------------------------------
G
A
S
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
-------------
E
F
T
--
E
G
K
-
D
----
E
M
G
W
I
K
S
F
Y
D
D
A
A
K
Q
G
-----
K
--------------
A
A
G
V
------
E
M
P
A
F
D
A
F
W
A
E
-
G
--
I
-
V
E
-
F
P
-------
V
T
D
GADF-------
V
---
R
Y
----------
A
--------
S
---
F
R
E
DPLLNP
L
G
---------------
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
EGYAV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
33
HHSearch
73.12
19%
0
- C- -
1G8K
5
AIOA_ALCFA
A:
[14-807]
-
A
Q
R
T
N
M
T
C
H
-
F
C
I
V
G
C
G
Y
H
V
Y
K
W
---
P
E
L
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
Y
D
-
I
M
V
---
V
P
D
K
A
-
C
V
-
V
N
S
G
L
S
S
T
R
G
G
K
M
A
S
Y
M
Y
T
P
TGDGK
E
R
L
S
A
P
R
------
L
Y
-------------
A
---------------
A
---------------
D
E
--
W
--
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
-
F
F
-
S
C
F
--
D
HGGAGG
G
--
F
E
N
T
W
-----
G
T
---
G
K
L
M
F
S
A
I
Q
-
T
--
P
M
V
R
I-
H
NRPAYN
S
E
C
H
A
T
R
E
M
----
G
I
G
----
E
------
L
NN---
A
Y
---
E
D
-
A
Q
-----------
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
Q
-
T
--------
N
Y
---------
F
L
N------
H
W
L
---
P
N
L
Q
GAT
T
S
K
K
K
E
R
F
P
N
E
-
N
--
F
P
----
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
-
V
A
-
I
--
A
R
H
V
AGNDR
V
L
H
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
G
W
I
D
K
P
F
I
E
A
H
T
K
---------
G
F
D
D
A
V
K
T
---------
N
------
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
Y
-
K
PKASGQA
P
R
T
M
H
A
Y
E
K
G
I
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
---
H
N
V
--
G
R
R
G
T
-----------------------
G
-------------
C
V
R
M
G
---------------
G
H
-
Q
-
E
G
Y
--
T
--------------
R
P
----
P
Y
P
--------------
G
-
D
----------------------------------
K
-----------------------------
K
----
I
Y
I
D
Q
E
L
I
--------------
K
-
G
K
------------------
G
R
I
M
T
W
W
G
C
N
N
F
Q
T
S
N
N
A
Q
A
L
R
E
A
I
L
Q
R
S
A
I
V
K
Q
A
M
Q
K
ARGAT
T
E
E
M
V
D
V
I
Y
E
A
T
Q
N
G
G
L
F
V
T
S
I
N
L
Y
P
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
-
N
L
T
S
M
N
---
G
E
--
R
R
-
I
R
L
S
----
E
K
F
M
D
P
P
G
T
A
M
A
D
C
L
I
A
A
R
I
A
N
A
L
R
D
M
Y
Q
K
D
GK
A
E
M
A
A
Q
F
E
G
F
D
W-
K
T
E
-
E
----
D
------
A
F
N
D
G
F
R
R
A
-----
G
QPGA
P
A
I
D
S
QGGST
G
H
L
V
------
T
Y
---
D
R
L
R
K
S
-
G
NN
G
-
V
Q
-
L
P
-------
V
V
S
WDESK
G
L
V
G
T
E
M
---
L
Y
----------
T
--------
E
---
G
K
-------
F
D
---------------
T
D
D
G
K
A
H
F
K
P
A
P
W
-----------------
N
G
L
P
A
T
-
V
Q
Q
Q
---------
K
D
K
Y
R
F
W
L
N
N
G
R
-
N
N
E
V
W
Q
T
A
YHDQ
Y
N
S
L
M
Q
E
-----
R
Y---
P
M
A
Y
I
E
------
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
S
T
F
A
M
V
Y
P
V
A
E
I
K
R
G
Q
T
F
M
L
F
G
Y
V
N
---------------------
G
I
-
Q
G
D
V
T
T
---
D
W
T
D
R
D
I
I
P
Y
Y
K
G
-
T
W
G
D
I
R
K
V
3
PsiBlast_PDB
72.77
25%
31
- C1 -
2VPY
4
?
A:
[47-689]
------------
C
F
W
R
C
G
I
V
A
H
A
V
---
G
N
-------------------------------------------
R
V
-
Y
K
V
---
E
G
Y
E
A
-
N
P
-
K
S
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
P
-----
D
R
L
K
R
P
L
I
R
VEGS
Q
R
-------------
G
---------------
E
---------------
G
K
--
Y
--
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
-
G
H
G
--
T
------
G
--
D
Y
W
F
V
D
---
F
L
P
---
A
A
W
---
G
S
P
N
A
--
A
K
P
S
--
V
------
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
--
I
------
G
G----
H
E
---
P
I
D
W
E
-----------
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
-
N
--------
T
Q
---------
L
--------
Q
D
F
---
A
---------------
L
A
-
L
--
K
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
-
A
A
-
K
--
A
--------
H
R
W
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
---------
G
F
E
E
L
K
A
H
V
--------
K
------
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
-
A
-------
H
K
P
R
A
V
L
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
-
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
--
G
R
P
G
G
FY
I
A
Q
S
P
Y
L
E
K
YPLPPLP
L
E
P
A
A
G
-------------
G
C
S
G
P
---------------
S
G
-
G
-
D
H
E
--
P
------
E
------
G
F
K
P
---
R
A
D
--------------
K
-
G
---------
K
--------------
F
-------
F
A
R
S
T
--------------------------
A
I
----
Q
E
L
I
E
P
M
I
------------
T
-
G
-
E
P
-----------
Y
----
P
-
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
T
------------------------------
K
E
A
L
K
N
L
-
D
L
Y
V
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
---
A
H
K
T
P
F
-
I
Q
L
R
----
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
E
Q
-------------
Y
F
P
--
W
K
T
I
E
----
E
------
Y
L
E
T
R
L
Q
S
L
----------------------
G
L
------
D
L
---
E
T
M
K
G
M
-
G
--
T
----
L
V
-------
Q
R
G
-----------
K
---
P
W
L
---------
E
--------
D
---
W
E
K
E
G
R
L
P
-
F
G
---------------
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
E
A
G
H
Q
P
L
----
P
V
F
T
P
P
E
E
P
P
EG
F
Y
R
-
L
-------
L
Y
G
R
S
P
-----
V
H
-
T
F
A
R
T
Q
N
N
----
W
V
-
L
M
E
M
-----
D
----
P
E
N
E
V
W
------
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
G
P
V
R
V
K
P
T
A
R
I
R
-----------------------------------------------------------------
14
PsiBlast_PDB
72.75
25%
14
- C1 -
1DMS
3
DSTOR_RHOCA
A:
[17-718]
------------------
F
T
A
T
V
E
---
N
G
-------------------------------------------
R
A
-
T
A
F
T
P
W
E
K
D
P
H
P
T
P
-
M
L
E
G
V
L
--------
D
S
I
Y
S
P
-----
T
R
I
K
Y
P
M
------
V
R
-------------
R
E
F
L
E
KGVNADRSTRG
N
---------------
G
D
--
F
--
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
Q
G
V
-
F
G
G
S
Y
G
--
W
------
K
--
S
P
G
R
L
H
N
C
T
T
L
L
---
R
R
M
L
T
-
L
A
G
G
Y
--
V
N
G
A
--
G
------
D
Y
S
T
G
A
A
------
Q
V
I
M
P
--
H
------
V
-----
V
G
---
T
L
E
V
Y
EQQTA
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
-
T
S
-
Q
IGWVIPEH
G
A
---------
Y
--------
P
G
L
---
E
---------------
A
L
-
K
--
A
K
----
G
T
K
V
I
V
I
D
P
V
R
T
K
T
-
V
E
-
F
F
G
A
--------
D
-
H
V
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
L
Y
D
K
D
F
I
A
N
Y
T
S
---------
G
F
D
K
F
L
P
Y
L
M
GETDSTP
K
------
T
A
E
W
A
S
D
I
--
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
K
-
S
-------
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
-------------
F
G
L
S
Y
HYSGGGTPSSS
G
P
A
L
S
G
-
I
-
T
D
G
----------------------------------------------------------------------------
G
A
S
V
--------------------------
I
P
----
V
A
R
V
V
D
M
L
E
N
PG
A
E
F
D
F
NG
T
R
-
S
-
K
F
-----------
P
----
D
-
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
M
------------------------------
V
K
A
W
E
K
L
-
E
T
F
I
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
-
N
D
I
E
T
I
---
G
D
Y
S
N
T
G
I
L
A
M
----
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
K
-------------
E
F
-----
T
-
E
----
G
------
K
D
E
M
G
W
I
K
S
-----
F
--------------
Y
D
D
A
------
A
-----
K
Q
G
K
A
-
G
--
G
-
V
E
-
M
P
-------
A
F
D
-----------
A
---
F
W
A
E
G
I
V
E
F
P
V
T
D
--------
G
---
A
D
-------
F
V
RY
A
S
F
R
E
DPLLNPLG
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
----
P
A
H
P
T
W
M
E
P
L
--
E
R
L
D
G
-------
P
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
----
L
N
G
T
V
L
R
EGYAV
Q
----
G
H
E
P
C
L
------
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
--------------------------------------------------------
2
PsiBlast_PDB
72.73
25%
30
- C1 -
2VPX
4
?
A:
[47-689]
------------
C
F
W
R
C
G
I
V
A
H
A
V
---
G
N
-------------------------------------------
R
V
-
Y
K
V
---
E
G
Y
E
A
-
N
P
-
K
S
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
P
-----
D
R
L
K
R
P
L
I
RVEGS
Q
R
-------------
G
---------------
E
---------------
G
K
--
Y
--
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
-
G
H
G
--
T
------
G
--
D
Y
W
F
V
D
---
F
L
P
---
A
A
W
---
G
S
P
N
A
--
A
K
P
S
--
V
------
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
--
I
------
G
G----
H
E
---
P
I
D
W
E
-----------
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
-
N
--------
T
Q
---------
L
--------
Q
D
F
---
A
---------------
L
A
-
L
--
K
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
-
A
A
-
K
--
A
--------
H
R
W
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
---------
G
F
E
E
L
K
A
H
V
--------
K
------
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
-
A
-------
H
K
P
R
A
V
L
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
-
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
--
G
R
P
G
G
FY
I
A
Q
S
P
Y
L
E
K
YPLPPLP
L
E
P
A
A
G
-------------
G
C
S
G
P
---------------
S
G
-
G
-
D
H
E
--
P
------
E
------
G
F
K
P
---
R
A
D
--------------
K
-
G
---------
K
--------------
F
-------
F
A
R
S
T
--------------------------
A
I
----
Q
E
L
I
E
P
M
I
------------
T
-
G
-
E
P
-----------
Y
----
P
-
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
T
------------------------------
K
E
A
L
K
N
L
-
D
L
Y
V
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
---
A
H
K
T
P
F
-
I
Q
L
R
----
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
E
Q
-------------
Y
F
P
--
W
K
T
I
E
----
E
------
Y
L
E
T
R
L
Q
S
L
----------------------
G
L
------
D
L
---
E
T
M
K
G
M
-
G
--
T
----
L
V
-------
Q
R
G
-----------
K
---
P
W
L
---------
E
--------
D
---
W
E
K
E
G
R
L
P
-
F
G
---------------
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
E
A
G
H
Q
P
L
----
P
V
F
T
P
P
E
E
P
P
EG
F
Y
R
-
L
-------
L
Y
G
R
S
P
-----
V
H
-
T
F
A
R
T
Q
N
N
----
W
V
-
L
M
E
M
-----
D
----
P
E
N
E
V
W
------
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
G
P
V
R
V
K
P
T
A
R
I
R
-----------------------------------------------------------------
32
HHSearch
72.61
23%
16
- C1 -
1TMO
3
TORA_SHEMA
A:
[39-811]
------
E
W
L
T
-
T
G
S
H
F
G
A
F
K
M
K
R
K
---
N
G
-------------------------------------------
V
I
-
A
E
V
---
K
P
F
D
L
-
D
K
-
Y
P
----
T
D
M
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N
G
I
R
G
M
V
Y
N
P
-----
S
R
V
R
Y
P
M
------
V
R
-------------
L
---------------
D
F
L
L
KGHKSNTHQRGD
F
R
--
F
--
V
R
V
T
W
D
K
A
L
T
L
F
K
H
S
L
D
E
V
Q
T
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Y
G
P
S
G
L
-
H
A
-
G
Q
T
--
G
W-----
R
--
A
T
G
Q
L
H
---
S
S
T
---
S
H
M
Q
R
-
A
V
G
-
M
H
G
N
Y
V
K
K
I
G
------
D
Y
S
T
G
A
G
Q
T
I
L
P
Y
V
L
G
----
S
TEVYAQ
G
TS---
W
P
---
L
I
-
L
E
-----------
H
S
D
T
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V
L
W
S
N
D
P
Y
K
-
N
L
-
Q
--------
V
G
---------
W
NAETH
E
S
F
A
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L
A
Q
L
K
---------------
E
K
V
K
--
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G
----
K
I
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V
I
S
I
D
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V
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K
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L
--
G
--------
C
E
Q
L
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P
Q
T
D
V
T
L
M
L
A
I
A
H
E
M
I
S
K
K
L
Y
D
D
K
F
I
Q
G
Y
S
L
---------
G
F
E
E
F
V
P
Y
V
--------
M
GTKDGV
A
K
T
P
E
W
A
A
P
I
C
G
V
E
A
H
V
I
R
D
L
A
K
T
L
V
-
K
-------
G
R
T
Q
F
M
M
G
W
C
I
Q
R
Q
Q
H
G
E
Q
P
Y
W
M
A
A
V
L
A
T
M
I
---
G
Q
I
--
G
L
P
G
G
-----------------------
G
-------------
I
S
Y
G
H
---------------
H
Y
-
S
S
I
G
V
--
P
------
S
SG----
A
A
A
P
G
--
A
F
P
--------------
R
-
N
LDENQKP--
L
--------------
F
DSSDFKG
A
S
S
T
I
--------------------------
P
V
----
A
R
W
I
D
A
I
L
EPG
K
T
I
D
A
----
N
G
S
K
V
V
-----------
Y
----
P
D
I
K
M
M
I
F
S
G
N
N
P
W
N
H
H
Q
D
R
N
R
M
------------------------------
K
Q
A
F
H
K
L
-
E
C
V
V
T
V
D
V
N
W
T
A
-
T
C
R
F
S
D
I
V
L
P
A
C
T
T
Y
E
R
-
N
D
I
D
V
Y
G
AY
A
N
--
R
G
-
I
L
A
M
----
Q
K
M
V
E
P
L
F
D
S
L
S
D
F
E
I
F
T
R
F
A
A
V
L
G
K
E
K
-------------
E
Y
T
RN
M
G
E
-
M
----
E
------
W
L
E
T
L
Y
N
E
C
K
A
A
N
A
G
K-------------
F
E
M
P
------
D
F
---
A
T
F
W
K
Q
-
G
--
Y
-
V
H
-
F
G
D
G
E
V
W
T
R
H
A
D
-----------
F
R
N
-
D
P
----------
E
--------
I
---
N
P
-------
L
G
---------------
T
P
S
G
L
I
E
I
F
S
R
K
I
D
Q
F
G
Y
---------
D
D
C
K
G
H
P
T
W
-
M
E
K
T
E
RSHGGP-
G
S
D
K
H
P
I
W
L
Q
S
C
H
-
P
D
K
R
L
H
S
Q
MC--
E
S
R
E
Y
R
E
-----
T
Y
AVN
G
R
E
P
V
Y
------
I
S
P
V
D
A
K
A
R
G
I
K
D
G
D
I
V
R
V
F
N
D
R
G
Q
L
L
A
G
A
V
V
S
D
N
F
P
K
G
I
V
R
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H
E
G
A
W
Y
G
P
V
G
KDGSTEGGAEVGALCS
Y
G
D
-
P
N
T
L
T
L
D
I
-
G
T
S
K
L
A
Q
A
C
S
A
Y
T
-
C
L
V
E
F
E
K
Y
1
PsiBlast_PDB
72.36
25%
30
- C1 -
2VPW
4
?
A:
[47-689]
------------
C
F
W
R
C
G
I
V
A
H
A
V
---
G
N
-------------------------------------------
R
V
-
Y
K
V
---
E
G
Y
E
A
-
N
P
-
K
S
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
P
-----
D
R
L
K
R
P
L
I
R
VEGS
Q
R
-------------
G
---------------
E
---------------
G
K
--
Y
--
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
-
G
H
G
--
T
------
G
--
D
Y
W
F
V
D
---
F
L
P
---
A
A
W
---
G
S
P
N
A
--
A
K
P
S
--
V
------
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
--
I
------
G
G----
H
E
---
P
I
D
W
E
-----------
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
-
N
--------
T
Q
---------
L
--------
Q
D
F
---
A
---------------
L
A
-
L
--
K
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
-
A
A
-
K
--
A
--------
H
R
W
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
---------
G
F
E
E
L
K
A
H
V
--------
K
------
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
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M
A
-
A
-------
H
K
P
R
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L
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
-
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
--
G
R
P
G
G
FY
I
A
Q
S
P
Y
L
E
K
YPLPPLP
L
E
P
A
A
G
-------------
G
C
S
G
P
---------------
S
G
-
G
-
D
H
E
--
P
------
E
------
G
F
K
P
---
R
A
D
--------------
K
-
G
---------
K
--------------
F
-------
F
A
R
S
T
--------------------------
A
I
----
Q
E
L
I
E
P
M
I
------------
T
-
G
-
E
P
-----------
Y
----
P
-
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
T
------------------------------
K
E
A
L
K
N
L
-
D
L
Y
V
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
---
A
H
K
T
P
F
-
I
Q
L
R
----
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
E
Q
-------------
Y
F
P
--
W
K
T
I
E
----
E
------
Y
L
E
T
R
L
Q
S
L
----------------------
G
L
------
D
L
---
E
T
M
K
G
M
-
G
--
T
----
L
V
-------
Q
R
G
-----------
K
---
P
W
L
---------
E
--------
D
---
W
E
K
E
G
R
L
P
-
F
G
---------------
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
E
A
G
H
Q
P
L
----
P
V
F
T
P
P
E
E
P
P
EG
F
Y
R
-
L
-------
L
Y
G
R
S
P
-----
V
H
-
T
F
A
R
T
Q
N
N
----
W
V
-
L
M
E
M
-----
D
----
P
E
N
E
V
W
------
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
G
P
V
R
V
K
P
T
A
R
I
R
-----------------------------------------------------------------
15
PsiBlast_PDB
72.04
25%
30
- C1 -
2E7Z
8
AHY_PELAE
A:
[8-677]
-------
S
C
D
I
N
C
------
V
V
E
A
E
V
K
A
D
G
-------------------------------------------
K
I
Q
T
K
S
---
I
S
E
P
H
-
P
T
-
T
P
P
N
S
I
C
M
K
S
V
N
A
D
T
I
R
T
H
K
-----
D
R
V
L
Y
P
L
------
K
N
VGS----------
K
---------------
R
---------------
G
E
Q
R
W
--
E
R
I
S
W
D
Q
A
L
D
E
I
A
E
K
L
K
K
I
I
A
K
Y
G
P
E
S
L
-
G
V
-
S
Q
T
--
E
------
I
--
N
Q
Q
S
E
Y
---
G
T
L
---
R
R
F
M
N
----------
L
L
--
G
------
S
P
N
W
T
S
---
A
M
Y
M
C
I
G
N
T
--
A
------
G
V
H
R
V
T
H
G
---
S
Y
S
F
A
S
FA--------
D
S
N
C
L
L
F
I
G
K
N
L
S
N
-
H
N
W
V
--------
S
Q
---------
F
--------
N
D
L
---
K
---------------
A
A
-
L
--
K
R
----
G
C
K
L
I
V
L
D
P
R
R
T
K
V
-
A
E
-
M
--
A
--------
D
I
W
L
P
L
R
Y
G
T
D
A
A
L
F
L
G
M
I
N
V
I
I
N
E
Q
L
Y
D
K
E
F
V
E
N
W
C
V
---------
G
F
E
E
L
K
E
R
V
--------
Q
------
E
Y
P
L
D
K
V
A
E
I
T
G
C
D
A
G
E
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R
K
A
A
V
M
F
A
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S
P
A
S
I
P
W
A
V
S
T
D
M
Q
K
N
S
C
S
A
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R
A
Q
C
I
L
R
A
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---
G
S
F
VN
G
A
E
I
L
-----------------------
G
-------------
A
P
H
S
D
LVP
I
S
K
---------
I
Q
-
M
-
H
E
A
--
L
------
P
------
E
E
K
K
---
K
L
---------------
Q
-
L
---------
G
--------------
T
-------
E
T
Y
P
F
LTYTGMSAL
E
E
P
S
E
R
V
YGVKYFHNMG
A
F
----
M
A
N
P
T
A
L
F
------------
T
-
A
-
M
A
-----------
T
EKP
Y
P
-
V
K
A
F
F
A
L
A
S
N
A
L
M
G
Y
A
N
Q
Q
N
A
------------------------------
L
K
G
L
M
N
Q
-
D
L
V
V
C
Y
D
Q
F
M
T
P
-
T
A
Q
L
A
D
Y
V
L
P
G
D
H
W
L
E
R
-
P
V
V
Q
P
N
---
W
E
G
I
P
F
-
G
N
T
S
----
Q
Q
V
V
E
P
A
G
E
A
K
D
E
Y
Y
F
I
R
E
L
A
V
R
M
G
L
E
E
-------------
H
F
P
--
W
K
D
-
R
L
---
E
------
L
I
N
Y
R
I
S
P
T
-----
G
--------------
M
E
--------
W
E
---
E
Y
Q
K
Q
Y
-
T
--
Y
-
M
S
K
L
P
-------
D
Y
F
-----------
G
---
P
-----------
E
--------
G
---
V
G
-------
V
A
---------------
T
P
S
G
K
V
E
L
Y
S
S
V
F
E
K
L
G
Y
D
P
L
----
P
Y
Y
H
E
P
L
Q
T
E
--
I
S
D
P
E
-------
L
A
K
E
Y
P
L
I
L
F
A
G
L
-
R
E
D
S
N
F
Q
S
CY--
H
Q
P
G
I
-------
L
----
R
D
A
E
P
D
P
V
A
L
--
L
H
P
K
T
A
Q
S
L
G
L
P
S
G
E
W
I
W
V
E
T
T
H
G
R
L
K
L
L
L
K
H
D
G
A
Q
P
E
G
T
I
R
I
P
H
G
R
W
C
-------------------------------------------------------
4
PsiBlast_PDB
71.87
25%
29
- C1 -
2VPZ
4
?
A:
[47-689]
------------
C
F
W
R
C
G
I
V
A
H
A
V
---
G
N
-------------------------------------------
R
V
-
Y
K
V
---
E
G
Y
E
A
-
N
P
-
K
S
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
P
-----
D
R
L
K
R
P
L
I
R
VEGS
Q
R
-------------
G
---------------
E
---------------
G
K
--
Y
--
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
-
G
H
G
--
T
------
G
--
D
Y
W
F
V
D
---
F
L
P
---
A
A
W
---
G
S
P
N
A
--
A
K
P
S
--
V
------
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
--
I
------
G
G----
H
E
---
P
I
D
W
E
-----------
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
-
N
--------
T
Q
---------
L
--------
Q
D
F
---
A
---------------
L
A
-
L
--
K
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
-
A
A
-
K
--
A
--------
H
R
W
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
---------
G
F
E
E
L
K
A
H
V
--------
K
------
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
-
A
-------
H
K
P
R
A
V
L
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
-
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
--
G
R
P
G
G
FY
I
A
Q
S
P
Y
L
E
K
YPLPPLP
L
E
P
A
A
G
-------------
G
C
S
G
P
---------------
S
G
-
G
-
D
H
E
--
P
------
E
------
G
F
K
P
---
R
A
D
--------------
K
-
G
---------
K
--------------
F
-------
F
A
R
S
T
--------------------------
A
I
----
Q
E
L
I
E
P
M
I
------------
T
-
G
-
E
P
-----------
Y
----
P
-
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
T
------------------------------
K
E
A
L
K
N
L
-
D
L
Y
V
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
---
A
H
K
T
P
F
-
I
Q
L
R
----
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
E
Q
-------------
Y
F
P
--
W
K
T
I
E
----
E
------
Y
L
E
T
R
L
Q
S
L
----------------------
G
L
------
D
L
---
E
T
M
K
G
M
-
G
--
T
----
L
V
-------
Q
R
G
-----------
K
---
P
W
L
---------
E
--------
D
---
W
E
K
E
G
R
L
P
-
F
G
---------------
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
E
A
G
H
Q
P
L
----
P
V
F
T
P
P
E
E
P
P
EG
F
Y
R
-
L
-------
L
Y
G
R
S
P
-----
V
H
-
T
F
A
R
T
Q
N
N
----
W
V
-
L
M
E
M
-----
D
----
P
E
N
E
V
W
------
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
G
P
V
R
V
K
P
T
A
R
I
R
-----------------------------------------------------------------
16
PsiBlast_PDB
70.64
24%
14
- C1 -
1TMO
3
TORA_SHEMA
A:
[84-758]
------------------------------------------------------------------------------------------------------------
N
P
-----
S
R
V
R
Y
P
M
------
V
R
L
D
F
L
L
KGHKSNTH
Q
---------------
R
---------------
G
D
--
F
R
F
V
R
V
T
W
D
K
A
L
T
L
F
K
H
S
L
D
E
V
-
Q
T
Q
Y
G
P
S
G
-
L
H
-
A
G
Q
TG
W
------
R
--
A
T
G
Q
L
H
---
S
S
T
S
H
M
Q
R
A
V
G
-
M
H
G
N
Y
--
V
K
K
I
--
G
------
D
Y
S
T
G
A
G
Q
T
I
L
P
Y
V
L
G
S
T
EV
Y
------
A
-----
Q
G
TS
W
P
L
I
L
E
-----------
H
S
D
T
I
V
L
W
S
-
N
D
P
Y
-
K
N
-
L
--------
Q
V
GWNAETH
E
S
F
--------
A
Y
L
---
A
---------------
Q
L
-
K
--
E
K
V
K
Q
G
K
I
R
V
I
S
I
D
P
V
V
T
K
T
Q
A
Y
-
L
--
G
--------
C
E
Q
L
Y
V
N
P
Q
T
D
V
T
L
M
L
A
I
A
H
E
M
I
S
K
K
L
Y
D
D
K
F
I
Q
G
Y
S
L
---------
G
F
E
E
F
V
P
Y
V
M
GTKDGVA
K
------
T
P
E
W
A
A
P
I
C
G
V
E
A
H
V
--
I
R
D
L
A
K
T
L
V
-
K
-------
G
R
T
Q
F
M
M
G
W
C
I
Q
R
Q
Q
H
G
E
Q
P
Y
-
W
M
A
A
V
L
A
T
M
I
--
G
Q
I
--
G
L
P
G
G
-----------------------
G
-------------
I
S
Y
G
H
HYSS-----------
I
G
-
V
-
P
S
S
--
G
------
A
------
A
A
P
G
---
A
F
P
RNLDENQKPLFDSS
D
-
F
---------
K
--------------
G
-------
A
S
S
T
I
--------------------------
P
V
----
A
R
W
I
D
A
I
L
------------
E
-
P
-
G
K
T
I
D
A
NG
S
K
V
V
Y
P
----
D
-
I
K
M
M
I
F
S
G
N
N
P
W
N
H
H
Q
D
R
N
R
M
------------------------------
K
Q
A
F
H
K
L
-
E
C
V
V
T
V
D
V
N
W
T
A
-
T
C
R
F
S
D
I
V
L
P
A
C
T
T
Y
E
R
-
N
D
I
------
D
V
Y
G
A
Y
-
A
N
R
G
I
L
A
M
Q
K
M
V
E
P
L
F
D
S
L
S
D
F
E
I
F
T
R
F
A
A
V
L
G
K
E
K
---------------
E
--
Y
T
R
-
N
MG
E
M
E
------
W
L
E
T
L
Y
N
E
C
-----
K
--------------
A
A
N
A
GK
F
E
M
P
D
F
---
A
T
F
W
K
Q
-
G
--
Y
-
V
H
-
F
G
-------
D
G
E
-----------
V
----
W
----------
T
--------
R
---
H
A
-------
D
F
R
N
DPEINPLG-----
T
P
S
G
L
I
E
I
F
S
R
K
I
D
Q
F
G
Y
D
D
C
KG
H
P
T
W
M
E
K
T
E
R
S
----
H
G
G
P
-------
G
S
D
K
H
P
I
W
L
Q
S
C
H
-
P
D
K
R
L
H
S
Q
----
M
C
E
S
R
E
Y
-----
R
----
E
T
Y
A
V
N
G
R
E
P
V
Y
I
S
P
V
D
A
K
A
R
G
I
K
D
G
D
I
V
R
V
F
N
D
R
G
Q
L
L
A
G
A
V
V
S
D
N
F
P
K
G
I
V
R
I
H
E
G
A
W
--------------------------------------------------------
21
HHSearch
70.51
24%
16
- C1 -
2E7Z
8
AHY_PELAE
A:
[1-727]
---
K
K
H
V
V
C
Q
-
S
C
D
I
N
C
V
V
E
A
E
V
K
A--
D
G
-------------------------------------------
K
I
-
Q
T
K
---
S
I
S
E
P
-
H
P
T
T
P
P
N
S
I
C
M
K
S
V
N
A
D
T
I
R
T
H
K
-----
D
R
V
L
Y
P
L
------
K
N
-------------
V
---------------
G
SKRGE----------
Q
R
--
W
--
E
R
I
S
W
D
Q
A
L
D
E
I
A
E
K
L
K
K
I
I
A
K
Y
G
P
E
S
L
-
G
V
-
S
Q
T
--
E
------
I
NQ
Q
S
E
Y
G
-----
T
L
---
R
R
F
M
N
-
L
L
G
-
S
--
P
N
W
T
SA
M
------
Y
M
C
I
G
N
T
A
G
V
H
R
V
T
H
G
----
S
------
Y
-----
S
F
---
A
S
-
F
A
-----------
D
S
N
C
L
L
F
I
G
K
N
L
S
N
-
H
N
-
W
--------
V
S
Q
--------
F
--------
N
D
L
---
K
---------------
A
A
-
L
--
K
R
----
G
C
K
L
I
V
L
D
P
R
R
T
K
V
-
A
E
-
M
--
A
--------
D
I
W
L
P
L
R
Y
G
T
D
A
A
L
F
L
G
M
I
N
V
I
I
N
E
Q
L
Y
D
K
E
F
V
E
N
W
C
V
---------
G
F
E
E
L
K
E
R
V
--------
Q
------
E
Y
P
L
D
K
V
A
E
I
T
G
C
D
A
G
E
I
R
K
A
A
V
M
F
A
-
T
E------
S
P
A
S
I
P
W
A
V
S
T
D
M
Q
K
N
S
C
S
A
I
R
A
Q
C
I
L
R
A
I
V
---
G
S
F
--
V
N
-
G
A
-----------------------
E
-------------
I
L
G
A
P
---------------
H
S
D
L
-
V
P
I
S
K
I
Q
MHEAL
P
E
E
K
K
K
L
Q
L
G
T
E--
T
Y
P
FLTYT---------
G
-
M
SAL
E
E
P
S
E
R
V
--------------
Y
-------
G
V
K
Y
F
HN------------------------
M
G
AF--
M
A
N
P
T
A
L
F
T
A
----------
M
A
T
-
E
K
-----------
P
----
Y
P
V
K
A
F
F
A
L
A
S
N
A
L
M
G
Y
A
N
Q
Q
N
A
------------------------------
L
K
G
L
M
N
Q
-
D
L
V
V
C
Y
D
Q
F
M
T
P
-
T
A
Q
L
A
D
Y
V
L
P
G
D
H
W
L
E
R
-
P
V
V
Q
P
N
---
W
E
G
I
P
F
-
G
N
T
S
----
Q
Q
V
V
E
P
A
G
E
A
K
D
E
Y
Y
F
I
R
E
L
A
V
R
M
G
L
E
E
-------------
H
F
P
W-
K
D
R
-
L
----
E
------
L
I
N
Y
R
I
S
P
----------------------
T
G
M
------
E
W
---
E
E
Y
Q
K
Q
-
Y
--
T
-
Y
M
-
S
K
-------
L
P
D
Y----------
F
---
G
P
----------
E
--------
G
---
V
G
-------
V
A
---------------
T
P
S
G
K
V
E
L
Y
S
S
V
F
E
K
L
------------
G
Y
D
P
L
P
Y
Y
-
H
E
P
L
Q
TEISD
P
E
L
A
K
E
Y
P
L
I
L
F
A
G
L
R
E
D
S
N
F
Q
S
C
YH--
Q
P
G
I
L
R
D
-----
A
E
---
P
D
P
V
A
L
------
L
H
P
K
T
A
Q
S
L
G
L
P
S
G
E
W
I
W
V
E
T
T
H
G
R
L
K
L
L
L
K
H
D
G
A
Q
P
E
G
T
I
R
I
P
H
G
R
W
C
P
E
QEGGPETGFSGAM-----
L
H
N
D
A
M
V
L
S
D
D
D
W
N
L
D
P
E
Q
G
L
P
N
L
R
G
G
I
L
A
K
A
Y
K
C
27
HHSearch
70.26
22%
8
* C1 *
2NAP
5
NAPA_DESDA
A:
[6-723]
-
E
K
W
V
K
G
V
C
R
-
Y
C
G
T
G
C
G
V
L
V
G
V
K
---
D
G
-------------------------------------------
K
A
-
V
A
I
---
Q
G
N
P
N
-
N
--
H
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
K
-----
E
R
V
T
Q
P
L
------
V
R
-------------
R
---------------
H
KG-------------
G
K
--
L
--
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
-
A
W
-
Y
G
S
--
G
------
Q
CL
T
E
E
S
Y
-----
V
A
---
N
K
I
F
K
G
G
F
G
-
T
--
N
N
V
D
GN
P
------
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
----
K
------
D
EPMG-
T
Y
---
A
D
-
I
D
-----------
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
-
P
--------
V
L
---------
F
--------
R
R
I
---
A
---------------
R
R
-
K
Q
V
E
P
----
G
V
K
I
I
V
A
D
P
R
R
T
N
T
-
S
R
-
I
--
A
--------
D
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS
D
F
E
G
Y
K
A
F
L
--------
E
------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
-
E
S------
A
A
T
M
S
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
---
G
Q
I
--
C
R
P
G
A
-----------------------
T
-------------
S
F
S
L
T
---------------
G
Q
P
N
A
C
G
G
--
V
------
R
------
D
G
G
A
LSH
L
L
P
--------------
A
-
G
---------
R
AIPN
A
K
H
R
A
E
M
E
K
L
W
-------
G
L
P
E
G
--------------------------
R
I
APEP
G
Y
H
T
V
A
L
F
E
A
----------
L
G
R
-
G
D
------------------
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
V
------------------------------
H
K
A
M
S
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
-
D
G
V
Y
G
C
---
G
E
--
R
R
-
Y
S
L
T
----
E
K
A
V
D
P
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
P
Q------------
L
V
N
F-
R
N
A
-
E
----
D
------
V
W
N
E
W
R
M
V
S
KGTTY
D
--------------
F
W
G
M
------
T
R
---
E
R
L
R
K
E
S
G
--
L
I
W
P
-
C
P
-------
S
E
D
HPGTS------
L
RYV
R
G
----------
Q
DPCVPADH
P
DRF
F
F
-------
Y
G
---------------
K
P
D
G
R
A
V
I
W
M
R
P
A
K
G
A
------------------
A
--
E
E
P
----------
D
A
E
Y
P
L
Y
L
T
S
M
R
-
V
I
D
H
W
H
T
A
TMTG
K
V
P
E
L
Q
K
-----
A
N---
P
I
A
F
V
E
------
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
E
L
P
A
R
V
S
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
---------------------
K
L
-
V
N
K
L
F
L
D
--
A
T
D
P
V
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A