@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0002: (2016-04-18 )
MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSGVLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHVEGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAGIGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMDVAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIAFNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYVYLLMPVRLPG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........--70.-.--------.......80........90....-.-.-..100..-.-.....110.......120.......130.-.....-.140.......150.......160.......170.-.....--.-180.......190.......200.......210.......220--..-......230.......240.......250.......260.......270.......280.......290..--.--...-...300.-......310........320-..-..-..--.330.......340.......350.......360.......370.......-380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDAATTRV
G
L
T
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
KNLPARPA
V
P
V
L
S
G
V
L
L
TGSDN
G
L
T
I
S
G
F
D
Y
E
VSAEAQV--
G
-
A
-
E
--------IVSPG
S
V
L
VS
G
R
L
L
S
D
I
T
R
ALPN-K-
P
-
V
D
V
-
H
V
E-G-
N
R
V
A
L
T
CGN
A
R
FSLPTMPVEDYPTLPTLP-EETGL-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
IAAGRDDTL
P
M
L
T
G
I
R
V
E
I
LG-
E
T
V
V
L
--
A
-AT
D
R
F
R
L
A
V
R
E
L
KWSASSPDI
E
A
A
V
LV
P
A
K
T
L
A
E
A
A
KAGIG-G--S
D
-
V
R
L
S
LGTGPGVGKD
G
L
L
GISGNGKR
S
T
T
R
LLDAE
F
P
K
F
R
Q
LLPTEHTA
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V--AD--R--G
A
Q
-
V
R
M
E
FAD-
G
S
V
R
L
SA-GADDVGRAEE
D
L
-
V
V
-DY-AG--E
P
L
T
I
A
FN
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
FGFTTAGK
P
A
L
LRPVSGDDRPVAGLN-GNGPFPAVST
D
Y
V
Y
L
L
M
P
VRLPG
4
PsiBlast_PDB
98.58
100%
-132
- C2 -
5AGV
11
DPO3B_MYCTU
A:
[14-406]
---------
L
T
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
--
G
-
A
-
E
--------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
N
-
K
-
P
-
V
D
V
-
H
V
E
-
G
-
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
-
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
-
E
T
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
S
P
D
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
I
G
-
G
--
S
D
-
V
R
L
S
L
G
T
G
P
G
V
G
K
D
G
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
D
--
R
--
G
A
Q
-
V
R
M
E
F
A
D
-
G
S
V
R
L
S
A
-
G
A
D
D
V
G
R
A
E
E
D
L
-
V
V
-
D
Y
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
D
D
R
P
---
L
N
-
G
N
G
P
F
P
A
V
S
T
D
Y
V
Y
L
L
M
P
V
R
L
P
G
23
HHSearch
98.47
99%
-132
- C2 -
5AGV
11
DPO3B_MYCTU
A:
[14-406]
---------
L
T
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
--
G
-
A
-
E
--------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
N
-
K
-
P
-
V
D
V
-
H
V
E
-
G
-
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
-
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
-
E
T
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
S
P
D
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
I
G
-
G
--
S
D
-
V
R
L
S
L
G
T
G
P
G
V
G
K
D
G
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
D
--
R
--
G
A
Q
-
V
R
M
E
F
A
D
-
G
S
V
R
L
S
A
G
A
D
D
V
-
G
R
A
E
E
D
L
-
V
V
-
D
Y
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
D
D
R
P
---
L
N
-
G
N
G
P
F
P
A
V
S
T
D
Y
V
Y
L
L
M
P
V
R
L
P
G
21
PsiBlast_CBE
97.04
100%
-130
- C2 -
5AGV
13
DPO3B_MYCTU
B:
[14-406]
---------
L
T
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
--
G
-
A
-
E
--------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
N
-
K
-
P
-
V
D
V
-
H
V
E
-
G
-
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
-
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
-
E
T
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
S
P
D
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
I
G
-
G
--
S
D
-
V
R
L
S
L
G
T
G
P
G
V
G
K
D
G
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
D
--
R
--
G
A
Q
-
V
R
M
E
F
A
D
-
G
S
V
R
L
S
A
-
G
A
D
D
V
G
R
A
E
E
D
L
-
V
V
-
D
Y
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
D
D
R
P
V
A
G
L
N
-
G
N
G
P
F
P
A
V
S
T
D
Y
V
Y
L
L
M
P
V
R
L
P
G
3
PsiBlast_PDB
95.58
100%
-134
- C2 -
5AGU
2
DPO3B_MYCTU
A:
[16-405]
-----------
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
------
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
--
G
-
A
-
E
--------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
N
-
K
-
P
-
V
D
V
-
H
V
E
-
G
-
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
-
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
-
E
T
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
S
P
D
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
I
G
-
G
--
S
D
-
V
R
L
S
L
G
T
G
P
G
V
G
K
D
G
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
-------
A
Q
-
V
R
M
E
F
A
D
-
G
S
V
R
L
S
A
-
G
A
D
D
V
G
R
A
E
E
D
L
-
V
V
-
D
Y
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
--------
N
-
G
N
G
P
F
P
A
V
S
T
D
Y
V
Y
L
L
M
P
V
R
L
P
-
2
PsiBlast_PDB
94.11
100%
-131
- C2 -
4TR7
-
DPO3B_MYCTO
A:
[10-400]
--------
G
L
T
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
-------
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
-
E
A
Q
V
--
G
-
A
-
E
--------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
N
-
K
-
P
-
V
D
V
-
H
V
E
-
G
-
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
-
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
-
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
-
E
T
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
-
P
D
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
-
G
-
G
--
S
D
-
V
R
L
S
L
G
----
V
G
K
D
G
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
D
--
R
--
G
A
Q
-
V
R
M
E
F
A
D
-
G
S
V
R
L
S
A
-
G
A
D
D
V
G
R
A
E
E
D
L
-
V
V
-
D
Y
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
D
-
R
P
V
A
G
L
N
-
G
N
G
P
F
P
A
V
S
T
D
Y
V
Y
L
L
M
P
V
R
---
5
PsiBlast_PDB
92.99
100%
-124
- C2 -
3RB9
-
DPO3B_MYCTU
A:
[8-402]
-------
V
G
L
T
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
--
G
-
A
-
E
--------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
N
-
K
-
P
-
V
D
V
-
H
V
E
-
G
-
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
-
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
-
E
T
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
S
P
D
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
I
G
-
G
--
S
D
-
V
R
L
S
L
G
T
G
P
G
V
G
K
D
G
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
D
--
R
--
G
A
Q
-
V
R
M
E
F
A
D
-
G
S
V
R
L
S
A
-
G
A
D
D
V
G
R
A
E
E
D
L
-
V
V
-
D
Y
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
D
D
R
P
V
A
G
L
N
-
G
N
G
P
F
P
A
V
S
T
D
Y
V
Y
L
L
M
P
V
R
L
P
G
1
PsiBlast_PDB
92.12
100%
-131
- C2 -
3P16
-
DPO3B_MYCTU
A:
[12-400]
-----------
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
--
G
-
A
-
E
--------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
N
-
K
-
P
-
V
D
V
-
H
V
E
-
G
-
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
-
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
-
E
T
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
S
P
D
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
I
G
-
G
--
S
D
-
V
R
L
S
L
G
T
G
P
G
V
G
K
D
G
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
D
--
R
--
G
A
Q
-
V
R
M
E
F
A
D
-
G
S
V
R
L
S
A
-
G
A
D
D
V
G
R
A
E
E
D
L
-
V
V
-
D
Y
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
D
---------------
A
V
S
T
D
Y
V
Y
L
L
M
P
V
R
L
--
6
PsiBlast_PDB
89.01
77%
-131
- C2 -
5AH2
1
?
A:
[13-400]
----------
T
D
L
K
F
R
V
V
R
E
D
F
A
D
A
V
A
W
V
A
R
S
L
P
T
R
P
T
I
P
V
L
A
G
V
L
L
T
G
T
D
E
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
V
K
V
--
S
-
A
-
E
--------
I
A
S
A
G
S
V
L
V
S
G
R
L
L
S
D
I
T
K
A
L
P
A
-
K
-
P
-
V
E
V
-
S
V
E
-
G
-
T
R
V
S
L
T
C
G
S
A
R
F
S
L
P
T
L
A
V
E
D
Y
P
A
L
P
A
L
P
-
E
E
T
G
V
-
I
A
S
D
L
F
A
E
A
I
G
Q
V
A
V
A
A
G
R
---
L
P
M
L
T
G
I
R
V
E
I
S
G
-
E
S
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
T
W
V
T
T
A
G
D
V
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
T
D
-
G
--
N
Q
-
V
H
L
A
L
G
S
G
A
S
V
G
K
D
G
L
L
G
I
R
S
E
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
A
E
H
T
A
V
A
T
I
G
V
A
E
L
T
E
A
I
K
R
V
A
L
V
--
A
D
--
R
--
G
A
Q
-
I
R
M
E
F
S
D
-
D
T
L
K
L
S
A
-
G
A
D
D
V
G
R
A
E
E
D
L
-
P
V
-
D
F
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
G
S
L
H
S
E
R
V
T
F
G
F
T
T
P
S
R
P
A
V
L
R
P
A
G
E
---------G
G
S
G
P
F
P
A
A
K
T
D
Y
V
Y
L
L
M
P
V
R
L
P
-
22
PsiBlast_CBE
88.90
77%
-128
- C2 -
5AH2
1
?
C:
[12-400]
---------
L
T
D
L
K
F
R
V
V
R
E
D
F
A
D
A
V
A
W
V
A
R
S
L
P
T
-
P
T
I
P
V
L
A
G
V
L
L
T
G
T
D
E
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
V
K
V
--
S
-
A
-
E
--------
I
A
S
A
G
S
V
L
V
S
G
R
L
L
S
D
I
T
K
A
L
P
A
-
K
-
P
-
V
E
V
-
S
V
E
-
G
-
T
R
V
S
L
T
C
G
S
A
R
F
S
L
P
T
L
A
V
E
D
Y
P
A
L
P
A
L
P
-
E
E
T
G
V
-
I
A
S
D
L
F
A
E
A
I
G
Q
V
A
V
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
S
G
-
E
S
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
T
W
V
T
T
A
G
D
V
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
T
D
-
G
--
N
Q
-
V
H
L
A
L
G
S
G
A
S
V
G
K
D
G
L
L
G
I
R
S
E
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
A
E
H
T
A
V
A
T
I
G
V
A
E
L
T
E
A
I
K
R
V
A
L
V
--
A
D
--
R
---
A
Q
-
I
R
M
E
F
S
D
-
D
T
L
K
L
S
A
-
G
A
D
D
V
G
R
A
E
E
D
L
-
P
V
-
D
F
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
G
S
L
H
S
E
R
V
T
F
G
F
T
T
P
S
R
P
A
V
L
R
P
A
G
E
---------G
G
S
G
P
F
P
A
A
K
T
D
Y
V
Y
L
L
M
P
V
R
L
P
-
7
PsiBlast_PDB
88.66
77%
-127
- C2 -
5AH4
1
?
A:
[13-400]
----------
T
D
L
K
F
R
V
V
R
E
D
F
A
D
A
V
A
W
V
A
R
S
L
P
T
R
----
V
L
A
G
V
L
L
T
G
T
D
E
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
V
K
V
--
S
-
A
-
E
--------
I
A
S
A
G
S
V
L
V
S
G
R
L
L
S
D
I
T
K
A
L
P
A
-
K
-
P
-
V
E
V
-
S
V
E
-
G
-
T
R
V
S
L
T
C
G
S
A
R
F
S
L
P
T
L
A
V
E
D
Y
P
A
L
P
A
L
P
-
E
E
T
G
V
-
I
A
S
D
L
F
A
E
A
I
G
Q
V
A
V
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
S
G
-
E
S
V
V
L
--
A
-
A
T
D
R
F
R
L
A
V
R
E
L
T
W
V
T
T
A
G
D
V
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
------
N
Q
-
V
H
L
A
L
G
S
G
A
S
V
G
K
D
G
L
L
G
I
R
S
E
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
A
E
H
T
A
V
A
T
I
G
V
A
E
L
T
E
A
I
K
R
V
A
L
V
--
A
D
--
R
--
G
A
Q
-
I
R
M
E
F
S
D
-
D
T
L
K
L
S
A
-
G
A
D
D
V
G
R
A
E
E
D
L
-
P
V
-
D
F
-
A
G
--
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
G
S
L
H
S
E
R
V
T
F
G
F
T
T
P
S
R
P
A
V
L
R
P
A
G
E
D
D
----
G
A
-G
G
S
G
P
F
P
A
A
K
T
D
Y
V
Y
L
L
M
P
V
R
L
P
-
12
PsiBlast_PDB
69.15
26%
-118
- C2 -
2AVT
-
?
A:
[2-376]
------------
I
Q
F
S
I
N
R
T
L
F
I
H
A
L
N
T
T
K
R
A
I
S
T
K
N
A
I
P
I
L
S
S
I
K
I
E
V
T
S
T
G
V
T
L
T
G
S
N
G
Q
I
S
I
E
N
T
I
P
V
G
-
L
-
L
--------
I
T
S
P
G
A
I
L
L
E
A
S
F
F
I
N
I
I
S
S
L
P
D
-
I
-
S
-
I
N
V
K
E
I
E
-
Q
-
H
Q
V
V
L
T
S
G
K
S
E
I
T
L
K
G
K
D
V
D
Q
Y
P
R
L
Q
E
V
S
-
T
E
N
P
L
I
L
K
T
K
L
L
K
S
I
I
A
E
T
A
F
A
A
S
L
Q
E
S
R
P
I
L
T
G
V
H
I
V
L
S
N
-
H
K
D
F
K
--
A
V
A
T
D
S
H
R
M
S
Q
R
L
I
T
L
D
N
T
S
A
D
F
--
M
V
V
L
P
S
K
S
L
R
E
F
--
S
A
V
F
-
T
--
D
D
-
I
E
----
T
V
E
V
F
F
S
P
S
Q
I
L
F
R
S
E
H
I
S
F
Y
T
R
L
L
E
G
N
Y
P
D
T
D
R
L
L
M
T
E
F
E
T
E
V
V
F
N
T
Q
S
L
R
H
A
M
E
R
A
F
L
I
--
S
N
A
T
Q
--
N
G
T
-
V
K
L
E
I
T
Q
-
N
H
I
S
A
H
V
-
N
S
P
E
V
G
K
V
N
E
D
L
D
I
V
-
S
Q
-
S
G
--
S
D
L
T
I
S
F
N
P
T
Y
L
I
E
S
L
K
A
I
K
S
E
T
V
K
I
H
F
L
S
P
V
R
P
F
T
L
T
P
--
G
D
E
E
E
----------------
S
F
I
Q
L
I
T
P
V
R
---
27
HHSearch
67.46
27%
-121
- C2 -
4TRT
-
?
A:
[1-361]
-----------
V
M
K
A
N
V
T
K
K
T
L
N
E
G
L
G
L
L
E
R
V
I
P
S
R
S
S
N
P
L
L
T
A
L
K
V
E
T
S
E
G
G
L
T
L
S
G
T
N
L
E
I
D
L
S
C
F
V
--
P
-
A
-
E
--------
V
Q
Q
P
E
N
F
V
V
P
A
H
L
F
A
Q
I
V
R
N
L
G
G
-
E
-
L
-
V
E
L
-
E
L
S
-
G
-
Q
E
L
S
V
R
S
G
G
S
D
F
K
L
Q
T
G
D
I
E
A
Y
P
P
L
S
F
P
A
-
Q
A
D
V
S
-
L
D
G
G
E
L
S
R
A
F
S
S
V
R
Y
A
A
S
N
E
A
F
Q
A
V
F
R
G
I
K
L
E
H
H
G
-
E
S
A
R
V
--
V
-
A
S
D
G
Y
R
V
A
I
R
D
F
P
A
S
G
----
D
G
K
N
L
I
I
P
A
R
S
V
D
E
L
I
R
V
L
K
D
----
G
E
-
A
R
F
T
Y
G
-------
D
G
M
L
T
V
T
T
D
R
V
K
M
N
L
K
L
L
D
G
D
F
P
D
Y
E
R
V
I
P
K
D
I
K
L
Q
V
T
L
P
A
T
A
L
K
E
A
V
N
R
V
A
V
L
--
A
D
--
K
NA
N
N
R
-
V
E
F
L
V
S
E
-
G
T
L
R
L
A
A
E
G
-
D
Y
-
G
R
A
Q
D
T
L
-
S
V
-
T
Q
-
G
G
TE
Q
A
M
S
L
A
F
N
A
R
H
V
L
D
A
L
G
P
I
D
G
-
D
A
E
L
L
F
S
G
S
T
S
P
A
I
F
R
A
V
G
G
------------------
G
G
G
Y
M
A
V
M
V
T
L
R
---
25
HHSearch
67.18
26%
-117
- C2 -
2AVT
-
?
A:
[1-377]
-----------
M
I
Q
F
S
I
N
R
T
L
F
I
H
A
L
N
T
T
K
R
A
I
S
T
K
N
A
I
P
I
L
S
S
I
K
I
E
V
T
S
T
G
V
T
L
T
G
S
N
G
Q
I
S
I
E
N
T
I
--
P
-
V
--GLL-----
I
T
S
P
G
A
I
L
L
E
A
S
F
F
I
N
I
I
S
S
L
P
D
-
I
-
S
-
I
N
V
-
K
E
I
E
Q
-
H
Q
V
V
L
T
S
G
K
S
E
I
T
L
K
G
K
D
V
D
Q
Y
P
R
L
Q
E
V
S
T
E
N
P
L
I
-
L
K
T
K
L
L
K
S
I
I
A
E
T
A
F
A
A
S
L
Q
E
S
R
P
I
L
T
G
V
H
I
V
L
S
N
H
K
D
F
K
A
--
V
-
A
T
D
S
H
R
M
S
Q
R
L
I
T
L
D
N
T
--
S
A
D
F
M
V
V
L
P
S
K
S
L
R
E
F
S
A
V
F
T
D
D
I
--
E
T
-
V
E
V
F
F
S
-------
P
S
Q
I
L
F
R
S
E
H
I
S
F
Y
T
R
L
L
E
G
N
Y
P
D
T
D
R
L
L
M
T
E
F
E
T
E
V
V
F
N
T
Q
S
L
R
H
A
M
E
R
A
F
L
I
--
S
N
--
A
T
Q
N
G
T
-
V
K
L
E
I
T
Q
-
N
H
I
S
A
H
V
N
S
P
E
V
-
G
K
V
N
E
D
L
-
D
I
V
S
Q
-
S
G
--
S
D
L
T
I
S
F
N
P
T
Y
L
I
E
S
L
K
A
I
K
S
E
T
V
K
I
H
F
L
S
P
V
R
P
F
T
L
T
P
G
D
E
------------------
E
E
S
F
I
Q
L
I
T
P
V
R
T
--
31
HHSearch
66.83
28%
-122
* C2 *
4TR6
-
DPO3B_BACSU
A:
[2-379]
-----------
H
M
K
F
T
I
Q
K
D
R
L
V
E
S
V
Q
D
V
L
K
A
V
S
S
R
T
T
I
P
I
L
T
G
I
K
I
V
A
S
D
D
G
V
S
F
T
G
S
D
S
D
I
S
I
E
S
F
I
--
P
-
K
-
E
EGDKEIVT
I
E
Q
P
G
S
I
V
L
Q
A
R
F
F
S
E
I
V
K
K
L
P
M
-
A
-
T
-
V
E
I
-
E
V
Q
-
N
Q
Y
L
T
I
I
R
S
G
K
A
E
F
N
L
N
G
L
D
A
D
E
Y
P
H
L
P
Q
I
E
E
H
H
A
I
Q
-
I
P
T
D
L
L
K
N
L
I
R
Q
T
V
F
A
V
S
T
S
E
T
R
P
I
L
T
G
V
N
W
K
V
E
Q
-
S
E
L
L
C
--
T
-
A
T
D
S
H
R
L
A
L
R
K
A
K
L
D
I
P
E
-
D
R
S
Y
N
V
V
I
P
G
K
S
L
T
E
L
S
K
I
L
D
D
-
N
Q-
E
L
-
V
D
I
V
I
T
-------
E
T
Q
V
L
F
K
A
K
N
V
L
F
F
S
R
L
L
D
G
N
Y
P
D
T
T
S
L
I
P
Q
D
S
K
T
E
I
I
V
N
T
K
E
F
L
Q
A
I
D
R
A
S
L
L
--
A
R
--
E
G
R
N
N
V
-
V
K
L
S
A
K
P
A
E
S
I
E
I
S
S
N
S
P
E
I
-
G
K
V
V
E
A
I
-
V
A
D
Q
I
-
E
G
--
E
E
L
N
I
S
F
S
P
K
Y
M
L
D
A
L
K
V
L
E
G
A
E
I
R
V
S
F
T
G
A
M
R
P
F
L
I
R
T
P
N
-------------------
D
E
T
I
V
Q
L
I
L
P
V
R
T
--
29
HHSearch
66.81
29%
-118
- C2 -
4TR8
1
?
A:
[9-382]
----
G
L
V
P
R
G
S
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
---
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
--
V
-
L
E
D
--------
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
-
D
-
V
L
I
D
I
-
R
V
E
-
E
-
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
-
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
-
G
T
L
R
S
--
V
-
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
-
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
--
G
E
-
V
G
I
V
L
G
-------
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
--
S
N
E-
K
--
Y
R
G
-
I
R
L
Q
L
S
N
-
G
L
L
K
I
Q
A
N
N
P
E
Q
-
E
E
A
E
E
E
V
-
Q
V
-
E
Y
-
N
G
--
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
-------------------
D
D
S
A
Y
V
V
M
P
M
R
---
28
HHSearch
66.70
29%
-127
- C2 -
4K3L
7
DPO3B_ECOLI
A:
[1-365]
------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
---------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
--
A
-
L
V
Q
--------
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
-
I
A
V
-
Q
L
E
-
G
-
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
-
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
L
R
T
--
V
-
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
--
L
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
-----
N
P
-
L
R
V
Q
I
G
-------
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
--
S
N
E-
K
--
F
R
G
-
V
R
L
Y
V
S
E
-
N
Q
L
K
I
T
A
N
N
P
E
Q
-
E
E
A
E
E
I
L
-
D
V
-
T
Y
-
S
G
--
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
-------------------
Q
S
A
A
Y
V
V
M
P
M
R
---
26
HHSearch
66.25
23%
-118
- C2 -
3T0P
14
?
A:
[1-366]
-----------
G
M
K
L
I
C
S
K
A
N
L
L
K
G
V
N
I
V
S
K
A
V
P
T
R
T
T
M
A
I
L
E
C
I
L
I
D
A
S
A
N
E
I
K
L
M
A
N
D
M
E
L
G
I
E
T
I
I
--
D
-
G
-
T
--------
I
E
E
R
G
I
I
A
L
D
A
K
I
F
S
E
I
V
R
K
L
P
D
-
N
-
D
-
V
T
I
-
E
T
D
-
A
S
F
K
T
V
I
S
C
E
K
A
K
F
N
I
I
G
K
S
G
D
D
F
S
Y
I
P
Y
V
E
R
N
E
S
I
V
-
L
S
Q
F
T
L
K
E
V
I
R
Q
T
I
F
S
I
A
D
N
D
N
N
K
L
M
T
G
E
L
F
E
I
E
E
-
N
K
L
R
V
--
V
-
S
L
D
G
H
R
I
S
I
R
Y
I
E
M
K
N
H
--
Y
D
S
K
K
V
V
V
P
G
K
T
L
Q
E
I
S
K
I
I
P
G
-
S
AD
E
D
-
V
V
I
Y
I
T
-------
N
N
H
I
V
F
E
F
E
N
T
T
V
V
S
R
L
I
E
G
E
Y
F
K
I
D
Q
M
L
S
S
D
Y
D
T
K
V
R
I
N
K
R
E
L
L
D
C
I
D
R
A
T
L
L
--
V
K
E--D-
K
K
P
-
I
I
M
N
I
T
D
-
G
N
M
E
L
R
I
N
S
-
F
I
-
G
S
M
N
E
D
I
-
D
I
-
D
K
-
D
G
--
K
D
I
M
I
G
F
N
P
K
F
F
I
D
A
L
R
V
I
D
E
E
E
V
N
L
Y
M
V
N
P
K
A
P
C
F
I
K
D
D
E
--------------------
G
K
F
I
Y
L
I
L
P
V
N
F
--
10
PsiBlast_PDB
66.10
27%
-111
- C2 -
2AWA
1
DPO3B_STRPN
A:
[16-388]
--------------
F
S
I
N
K
N
L
F
L
Q
A
L
N
T
T
K
R
A
I
S
S
K
N
A
I
P
I
L
S
T
V
K
I
D
V
T
N
E
G
I
T
L
I
G
S
N
G
Q
I
S
I
E
N
F
I
--
S
-
Q
-
K
NEDAGLL-
I
T
S
L
G
S
I
L
L
E
A
S
F
F
I
N
V
V
S
S
L
P
D
-
V
-
T
-
L
D
F
K
E
I
E
-
Q
-
N
Q
I
V
L
T
S
G
K
S
E
I
T
L
K
G
K
D
S
E
Q
Y
P
R
I
Q
E
I
S
-
A
S
T
P
L
I
L
E
T
K
L
L
K
K
I
I
N
E
T
A
F
A
A
S
T
Q
E
S
R
P
I
L
T
G
V
H
F
-
V
L
S
-
Q
H
K
E
L
K
T
V
-
A
T
D
S
H
R
L
S
Q
K
K
L
T
L
E
K
N
S
D
D
F
D
--
V
V
I
P
S
R
S
L
R
E
F
--
S
A
V
F
-
T
--
D
D
-
I
E
---
T
V
E
I
F
F
A
N
N
Q
I
L
F
R
S
E
N
I
S
F
Y
-
T
R
L
L
E
G
N
Y
P
D
T
D
R
L
I
P
T
D
F
N
T
T
I
T
F
N
V
V
N
L
R
Q
S
M
E
R
A
R
L
L
S
S
A
T
--
Q
--
N
G
T
-
V
K
L
E
I
K
D
-
G
V
V
S
A
H
V
-
H
S
P
E
V
G
K
V
N
E
E
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-
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T
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D
Q
V
T
G
--
E
D
L
T
I
S
F
N
P
T
Y
L
I
D
S
L
K
A
L
N
S
E
K
V
T
I
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F
I
S
A
V
R
P
F
T
L
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P
A
D
T
D
E
------------------
D
F
M
Q
L
I
T
P
V
R
---
17
PsiBlast_PDB
64.64
27%
-112
- C2 -
1UNN
-
DPO3B_ECOLI
A:
[1-366]
------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
--
A
L
V
-
Q
--------
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
-
E
-
I
A
V
-
Q
L
E
-
G
-
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
-
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
L
R
T
--
V
-
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
--
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
-
G
--
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
-------
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
--
S
N
--
E
--
K
F
R
G
V
R
L
Y
V
S
E
-
N
Q
L
K
I
T
A
-
N
N
P
E
Q
E
E
A
E
E
I
L
-
D
V
-
T
Y
-
S
G
--
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
-----
V
S
S
V
Q
I
E
D
--------------
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
--
14
PsiBlast_PDB
64.31
27%
-116
- C2 -
3Q4L
1
DPO3B_ECOLI
A:
[3-368]
------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
--
A
L
V
-
Q
--------
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
-
E
-
I
A
V
-
Q
L
E
-
G
-
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
-
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
L
R
T
--
V
-
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
--
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
-
G
--
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
-------
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
--
S
N
--
E
--
K
F
R
G
V
R
L
Y
V
S
E
-
N
Q
L
K
I
T
A
-
N
N
P
E
Q
E
E
A
E
E
I
L
-
D
V
-
T
Y
-
S
G
--
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
-----
V
S
S
V
Q
I
E
D
--------------
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
--