@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0009: (2016-04-18 )
MADCDSVTNSPLATATATLHTNRGDIKIALFGNHAPKTVANFVGLAQGTKDYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFHPELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVIDAESQRVVEAISKTATDGNDRPTDPVVIESITIS
Atome Classification :
(99 SA)
.........10........20....-----....30........40........50........60........70........80...-..---.-.-.-90.-----.----.----------------------------...---...100......-.110---.......-.----120.......130......--------.--------140........150.-.......160..---.-.----.--..170........180-------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAD
C
D
SVTNSPL
A
T
A
T
A
T
L
HTNRG
D
-----
I
K
I
A
L
FGNHA
P
K
T
V
A
N
F
V
G
LAQGTKDYSTQNASGGPSGPFY
D
G
A
V
F
H
R
V
I
Q
G
F
M
IQGGD-PT---G-T-G-R-G-----G----P----------------------------GYK---
F
A
D
EFHPELQFD-K
P
Y
----
L
L
A
MANA-G----PGTNG
S
Q
F
F
I
T
VGKTPHLN--------R--------R-H
T
I
F
G
E
VIDA-
E
S
-
Q
R
V
V
E
A
I
S
K
TAT---D-G----N--DRP-TD
P
V
V
I
E
S
I
TIS-------------
103
HHSearch
96.74
100%
-104
- C6 -
1W74
-
PPIA_MYCTU
A:
[12-182]
-----------
L
A
T
A
T
A
T
L
H
T
N
R
G
D
-----
I
K
I
A
L
F
G
N
H
A
P
K
T
V
A
N
F
V
G
L
A
Q
G
T
K
D
Y
S
T
Q
N
A
S
G
G
P
S
G
P
F
Y
D
G
A
V
F
H
R
V
I
Q
G
F
M
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
R
-
G
-----
G
----
P
----------------------------
G
Y
K
---
F
A
D
E
F
H
P
E
L
Q
F
D
-
K
P
Y
----
L
L
A
M
A
N
A
-
G
----
P
G
T
N
G
S
Q
F
F
I
T
V
G
K
T
P
H
L
N
--------
R
--------
R
-
H
T
I
F
G
E
V
I
D
A
-
E
S
-
Q
R
V
V
E
A
I
S
K
T
A
T
---
D
-
G
----
N
--
D
R
P
-
T
D
P
V
V
I
E
S
I
T
I
S
-------------
1
PsiBlast_PDB
96.74
100%
-104
- C6 -
1W74
-
PPIA_MYCTU
A:
[12-182]
-----------
L
A
T
A
T
A
T
L
H
T
N
R
G
D
-----
I
K
I
A
L
F
G
N
H
A
P
K
T
V
A
N
F
V
G
L
A
Q
G
T
K
D
Y
S
T
Q
N
A
S
G
G
P
S
G
P
F
Y
D
G
A
V
F
H
R
V
I
Q
G
F
M
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
R
-
G
-----
G
----
P
----------------------------
G
Y
K
---
F
A
D
E
F
H
P
E
L
Q
F
D
-
K
P
Y
----
L
L
A
M
A
N
A
-
G
----
P
G
T
N
G
S
Q
F
F
I
T
V
G
K
T
P
H
L
N
--------
R
--------
R
-
H
T
I
F
G
E
V
I
D
A
-
E
S
-
Q
R
V
V
E
A
I
S
K
T
A
T
---
D
-
G
----
N
--
D
R
P
-
T
D
P
V
V
I
E
S
I
T
I
S
-------------
113
HHSearch
78.10
51%
-106
- C6 -
2A2N
1
PPWD1_HUMAN
A:
[21-176]
-------------
S
D
S
A
I
I
H
T
S
M
G
D
-----
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
C
V
H
S
R
---------------
N
G
Y
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
-
P
T
---
G
-
T
-
G
-
M
-
G
-----
G
----
E
S
IW-------------------------
G
G
E
---
F
E
D
E
F
H
S
T
L
R
H
D
-
R
P
Y
----
T
L
S
M
A
N
A
-
G
----
S
N
T
N
G
S
Q
F
F
I
T
V
V
P
T
P
W
L
D
--------
N
--------
K
-
H
T
V
F
G
R
V
T
K
---
G
-
M
E
V
V
Q
R
I
S
N
V
K
V
---
N
-
P
K---
T
--
D
K
P
-
Y
E
D
V
S
I
I
N
I
T
V
K
-------------
57
PsiBlast_CBE
77.86
39%
-109
- C6 -
1ZKC
1
PPIL2_HUMAN
A:
[16-173]
----------
P
R
G
S
G
Y
V
R
L
H
T
N
K
G
D
-----
L
N
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
I
R
L
C
K
K
H
---------------
Y
Y
D
G
T
I
F
H
R
S
I
R
N
F
V
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
T
-
G
-----
G
----
E
----------------------------
S
Y
W
G
K
P
F
K
D
E
F
R
P
N
L
S
H
T
-
G
R
G
----
I
L
S
M
A
N
S
-
G
----
P
N
S
N
R
S
Q
F
F
I
T
F
R
S
C
A
Y
L
D
--------
K
--------
K
-
H
T
I
F
G
R
V
V
G
G
-
F
D
---
V
L
T
A
M
E
N
V
E
S
---
D
P
K
----
T
--
D
R
P
-
K
E
E
I
R
I
D
A
T
T
V
--------------
56
PsiBlast_CBE
77.26
39%
-105
- C6 -
1ZKC
1
B:
[16-173]
----------
P
R
G
S
G
Y
V
R
L
H
T
N
K
G
D
-----
L
N
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
I
R
L
C
K
K
H
---------------
Y
Y
D
G
T
I
F
H
R
S
I
R
N
F
V
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
T
-
G
-----
G
----
E
----------------------------
S
Y
W
G
K
P
F
K
D
E
F
R
P
N
L
S
H
T
-
G
R
G
----
I
L
S
M
A
N
S
-
G
----
P
N
S
N
R
S
Q
F
F
I
T
F
R
S
C
A
Y
L
D
--------
K
--------
K
-
H
T
I
F
G
R
V
V
G
G
-
F
D
---
V
L
T
A
M
E
N
V
E
S
---
D
P
K
----
T
--
D
R
P
-
K
E
E
I
R
I
D
A
T
T
V
--------------
15
PsiBlast_PDB
77.21
36%
-95
- C6 -
4R3F
11
?
A:
[11-197]
---------
E
P
Q
P
T
G
A
V
I
I
H
T
T
Q
G
D
-----
L
K
V
E
L
F
A
K
Q
T
P
L
T
C
R
N
F
L
-----------
Q
H
S
L
D
G
----
Y
Y
D
G
T
I
F
H
R
L
V
P
G
F
I
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
H
-
G
-----
G
----
E
S
IYDGGAFSGDLDPWPMDQRKGHNAGPM
G
V
N
---
F
K
D
E
F
H
S
R
L
K
F
N
-
R
R
G
----
L
L
G
M
A
N
E
-
G
A---
P
D
T
N
G
S
Q
F
F
F
T
L
G
K
A
E
E
L
N
--------
N
--------
K
-
N
T
L
F
G
R
V
A
A
G
-
D
T
I
Y
N
L
M
K
W
G
E
A
E
L
I
---
E
-
G
----
T
--
E
R
P
-
Q
Y
P
V
K
I
T
N
I
E
I
--------------
117
HHSearch
76.64
50%
-103
- C6 -
2OK3
2
PPIL3_HUMAN
A:
[1-155]
--------------
M
S
V
T
L
H
T
D
V
G
D
-----
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
A
---------------
S
N
Y
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
T
---
G
-
T
-
G
-
R
-
G
-----
G
----
N
S
IW-------------------------
G
K
K
---
F
E
D
E
Y
S
E
Y
L
K
H
N
-
V
R
G
----
V
V
S
M
A
N
N
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
P
H
L
D
--------
M
--------
K
-
Y
T
V
F
G
K
V
I
D
---
G
-
L
E
T
L
D
E
L
E
K
L
P
V
---
N
E
K
----
T
--
Y
R
P
-
L
N
D
V
H
I
K
D
I
T
I
H
-------------
108
HHSearch
76.36
44%
-110
- C6 -
2FU0
-
?
A:
[5-159]
-------------
P
K
S
A
I
I
Y
T
T
M
G
D
-----
I
H
I
S
L
F
Y
K
E
C
K
K
T
V
Q
N
F
S
V
H
S
I
---------------
N
G
Y
Y
N
N
C
I
F
H
R
V
I
K
H
F
M
V
Q
T
G
D
-
P
S
---
G
-
D
-
G
-
T
-
G
-----
G
----
E
S
IW-------------------------
G
N
E
---
F
E
D
E
F
F
D
H
L
N
H
S
-
K
P
F
----
M
V
S
M
A
N
C
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
V
P
C
P
W
L
D
--------
F
--------
K
-
H
T
V
F
G
K
V
T
Q
---
G
-
S
K
I
V
L
D
I
E
K
V
R
T
---
D
-
K
----
R
--
D
K
P
-
L
E
D
I
K
I
L
N
I
K
I
N
-------------
104
HHSearch
76.08
49%
-107
- C6 -
2X7K
3
PPIL1_HUMAN
A:
[9-165]
-----------
W
Q
P
P
N
V
Y
L
E
T
S
M
G
I
-----
I
V
L
E
L
Y
W
K
H
A
P
K
T
C
K
N
F
A
E
L
A
R
---------------
R
G
Y
Y
N
G
T
K
F
H
R
I
I
K
D
F
M
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
R
-
G
-----
G
----
A
S
IY-------------------------
G
K
Q
---
F
E
D
E
L
H
P
D
L
K
F
T
-
G
A
G
----
I
L
A
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
V
T
L
A
P
T
Q
W
L
D
--------
G
--------
K
-
H
T
I
F
G
R
V
C
Q
---
G
-
I
G
M
V
N
R
V
G
M
V
E
T
---
N
-
S
----
Q
--
D
R
P
-
V
D
D
V
K
I
I
K
A
Y
P
S
-------------
111
HHSearch
75.84
43%
-100
- C6 -
1ZKC
1
PPIL2_HUMAN
A:
[12-174]
------
S
G
L
V
P
R
G
S
G
Y
V
R
L
H
T
N
K
G
D
-----
L
N
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
I
R
L
C
K
---------------
K
H
Y
Y
D
G
T
I
F
H
R
S
I
R
N
F
V
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
T
-
G
-----
G
----
E
S
YW-------------------------
G
K
P
---
F
K
D
E
F
R
P
N
L
S
H
T
-
G
R
G
----
I
L
S
M
A
N
S
-
G
----
P
N
S
N
R
S
Q
F
F
I
T
F
R
S
C
A
Y
L
D
--------
K
--------
K
-
H
T
I
F
G
R
V
V
G
---
G
-
F
D
V
L
T
A
M
E
N
V
E
S
---
D
P
K
----
T
--
D
R
P
-
K
E
E
I
R
I
D
A
T
T
V
F
-------------
112
HHSearch
75.49
45%
-92
- C6 -
4R3F
11
?
A:
[9-198]
-------
N
L
E
P
Q
P
T
G
A
V
I
I
H
T
T
Q
G
D
-----
L
K
V
E
L
F
A
K
Q
T
P
L
T
C
R
N
F
L
Q
H
S
L
---------------
D
G
Y
Y
D
G
T
I
F
H
R
L
V
P
G
F
I
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
H
-
G
-----
G
----
E
S
IYDGGAFSGDLDPWPMDQRKGHNAGPM
G
V
N
---
F
K
D
E
F
H
S
R
L
K
F
N
-
R
R
G
----
L
L
G
M
A
N
E
-
G
A---
P
D
T
N
G
S
Q
F
F
F
T
L
G
K
A
E
E
L
N
--------
N
--------
K
-
N
T
L
F
G
R
V
A
A
---
G
-
D
T
I
Y
N
L
M
K
W
G
E
A
ELI
E
-
G
----
T
--
E
R
P
-
Q
Y
P
V
K
I
T
N
I
E
I
L
-------------
114
HHSearch
75.31
38%
-107
- C6 -
3BKP
4
?
A:
[12-192]
----
E
N
L
Y
F
Q
G
S
T
R
G
K
V
V
L
H
T
S
L
G
D
-----
L
D
V
E
L
W
A
R
E
C
P
L
A
C
R
N
F
V
Q
L
C
L
---------------
E
G
Y
Y
V
N
T
I
F
H
R
V
V
K
D
F
I
V
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
R
-
G
-----
G
----
A
DTTFD-----------------------
G
K
P
---
F
D
V
E
T
H
P
R
L
K
F
R
-
Y
R
G
----
L
V
G
V
A
N
L
-
G
------
T
N
G
N
Q
F
F
I
T
L
A
R
A
D
V
L
N
--------
N
--------
A
-
Y
T
L
F
G
K
V
T
G
H
--
T
-
L
Y
N
L
M
K
F
N
D
L
E
V
---
G
-
K
----
E
--
D
R
P
-
M
T
P
P
F
I
K
S
V
D
V
L
-------------
110
HHSearch
75.19
43%
-97
- C6 -
2B71
5
?
A:
[34-191]
---------
G
H
T
E
R
G
Y
I
T
I
Y
T
N
L
G
D
-----
F
E
V
E
L
Y
W
Y
H
S
P
K
T
C
L
N
F
Y
T
L
C
E
---------------
M
G
F
Y
D
N
T
I
F
H
R
V
I
P
N
F
V
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
K
-
G
-----
G
----
K
S
IY-------------------------
G
E
Y
---
F
E
D
E
I
N
K
E
L
K
H
T
-
G
A
G
----
I
L
S
M
S
N
N
-
G
----
P
N
T
N
S
S
Q
F
F
I
T
L
A
P
L
P
H
L
D
--------
G
--------
K
-
H
T
I
F
A
R
V
S
K
---
N
-
M
T
C
I
E
N
I
A
S
V
Q
T
---
T
-
A
----
T
--
N
K
P
-
I
F
D
L
K
I
L
R
T
S
T
--------------
109
HHSearch
75.08
43%
-104
- C6 -
2POE
4
?
A:
[15-174]
------------
Y
F
Q
G
V
R
I
I
T
N
Y
G
D
-----
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
L
A
L
S
A
---------------
S
G
Y
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
K
-
G
-----
G
----
E
S
IY-------------------------
G
R
Y
---
F
D
D
E
I
Y
P
E
L
K
Y
D
-
R
R
G
----
I
L
S
M
A
S
K
-
G
AKK-
P
N
T
N
G
S
Q
F
F
I
T
Y
S
S
L
P
Q
L
N
--------
G
--------
E
-
Y
V
I
F
G
K
L
I
D
---
G
-
F
E
T
L
N
T
L
E
N
C
P
S
---
D
-
K
----
S
--
H
K
P
-
I
D
E
I
I
I
K
D
I
V
I
H
-------------
4
PsiBlast_PDB
74.76
46%
-103
- C6 -
2A2N
1
PPWD1_HUMAN
A:
[23-175]
---------------
S
A
I
I
H
T
S
M
G
D
-----
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
C
--------
V
H
S
R
N
G
-------
Y
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
-
P
T
---
G
-
T
-
G
-
M
-
G
-----
G
----
E
S
IW-------------------------
G
G
E
---
F
E
D
E
F
H
S
T
L
R
H
D
-
R
P
Y
----
T
L
S
M
A
N
A
-
G
----
S
N
T
N
G
S
Q
F
F
I
T
V
V
P
T
P
W
L
D
--------
N
--------
K
-
H
T
V
F
G
R
V
--
T
-
K
G
-
M
E
V
V
Q
R
I
S
N
V
K
V
---
N
P
K
----
T
--
D
K
P
-
Y
E
D
V
S
I
I
N
I
T
V
--------------
21
PsiBlast_CBE
74.74
46%
-101
- C6 -
2A2N
1
C:
[23-175]
---------------
S
A
I
I
H
T
S
M
G
D
-----
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
C
--------
V
H
S
R
N
G
-------
Y
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
-
P
T
---
G
-
T
-
G
-
M
-
G
-----
G
----
E
SIW-------------------------
G
G
E
---
F
E
D
E
F
H
S
T
L
R
H
D
-
R
P
Y
----
T
L
S
M
A
N
A
-
G
----
S
N
T
N
G
S
Q
F
F
I
T
V
V
P
T
P
W
L
D
--------
N
--------
K
-
H
T
V
F
G
R
V
--
T
-
K
G
-
M
E
V
V
Q
R
I
S
N
V
K
V
---
N
P
K
----
T
--
D
K
P
-
Y
E
D
V
S
I
I
N
I
T
V
--------------
22
PsiBlast_CBE
73.53
44%
-107
- C6 -
2OJU
1
PPIL3_HUMAN
B:
[8-160]
---------------
S
V
T
L
H
T
D
V
G
D
-----
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
---------------
A
S
N
Y
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
T
---
G
-
T
-
G
-
R
-
G
-----
G
N
S
I-
W
----------------------------
G
K
K
---
F
E
D
E
Y
S
E
Y
L
K
H
N
-
V
R
G
----
V
V
S
M
A
N
N
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
P
H
L
D
--------
M
--------
K
-
Y
T
V
F
G
K
V
I
D
G
L
E
T
-
L
D
E
L
E
K
L
P
--
V
N
---
E
-
K
----
T
--
Y
R
P
-
L
N
D
V
H
I
K
D
I
T
I
--------------
115
HHSearch
73.04
35%
-106
- C6 -
3BO7
13
?
A:
[5-172]
------------
K
K
G
Y
L
R
I
V
T
T
Q
G
S
-----
L
N
I
E
L
H
A
D
M
A
P
R
A
C
D
S
F
L
R
L
C
A
---------------
V
K
Y
F
D
D
T
I
F
H
R
C
I
R
N
F
M
I
Q
G
G
R
-
A
E
---
L
-
R
-
Q
-
P
--QSP
R
S
I
S
GFP
G
----------------------------
G
A
P
---
F
E
D
E
F
D
N
R
L
V
H
Q
-
G
I
G
----
V
L
S
M
A
N
D
-
G
----
K
H
S
N
L
S
E
F
F
I
T
F
K
S
C
E
H
L
N
--------
N
--------
K
-
H
T
I
F
G
R
V
V
G
---
G
-
L
D
V
L
R
Q
W
E
K
L
E
T
---
D
-
K
----
K
--
D
K
P
-
L
K
P
P
K
V
E
E
I
I
V
F
-------------
51
PsiBlast_CBE
72.68
42%
-90
- C6 -
2WFJ
3
PPIG_HUMAN
A:
[24-176]
-----------------------
G
R
-----
V
V
F
E
L
F
S
D
V
C
P
K
T
C
E
N
F
R
C
L
C
T
G
E
K
--
G
T
G
K
S
T
Q
K
P
--
L
H
Y
K
S
C
L
F
H
R
V
V
K
D
F
M
V
Q
G
G
D
F
S
E
---
G
-
N
-
G
-
R
-
G
-----
G
----
E
S
IY-------------------------
G
G
F
---
F
E
D
E
S
F
A
-
V
K
H
N
-
K
E
F
----
L
L
S
M
A
N
R
-
G
----
K
D
T
N
G
S
Q
F
F
I
T
T
K
P
T
P
H
L
D
--------
G
--------
H
-
H
V
V
F
G
Q
V
I
S
G
----
Q
E
V
V
R
E
I
E
N
Q
K
T
---
D
-
A
----
A
--
S
K
P
-
F
A
E
V
R
I
L
S
C
----------------
13
PsiBlast_PDB
72.43
41%
-104
- C6 -
2QER
5
?
A:
[23-173]
--------------------
T
N
Y
G
D
-----
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
L
A
L
S
----------
A
S
G
-----
Y
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
K
-
G
-----
G
----
E
S
IY-------------------------
G
R
Y
---
F
D
D
E
I
Y
P
E
L
K
Y
D
-
R
R
G
----
I
L
S
M
A
S
---ASKK
P
N
T
N
G
S
Q
F
F
I
T
Y
S
S
L
P
Q
L
N
--------
G
--------
E
-
Y
V
I
F
G
K
L
I
D
G
----
F
E
T
L
N
T
L
E
N
C
P
S
---
D
-
K
----
S
--
H
K
P
-
I
D
E
I
I
I
K
D
I
V
I
--------------
7
PsiBlast_PDB
72.01
46%
-108
- C6 -
2X7K
3
PPIL1_HUMAN
A:
[16-159]
------------------
L
E
T
S
M
G
I
-----
I
V
L
E
L
Y
W
K
H
A
P
K
T
C
K
N
F
A
E
L
A
R
R
G
---------------
Y
Y
N
G
T
K
F
H
R
I
I
K
D
F
M
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
R
-
G
-----
G
----
A
S
IY-------------------------
G
K
Q
---
F
E
D
E
L
H
P
D
L
K
F
T
-
G
A
G
----
I
L
A
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
V
T
L
A
P
T
Q
W
L
D
--------
G
--------
K
-
H
T
I
F
G
R
V
--
C
-
Q
G
-
I
G
M
V
N
R
V
G
M
V
E
T
---
N
-
S
----
Q
--
D
R
P
-
V
D
D
V
K
I
-------------------
10
PsiBlast_PDB
71.85
40%
-92
- C6 -
4R3E
3
CWC27_HUMAN
A:
[10-168]
---------
E
P
P
T
N
G
K
V
L
L
K
T
T
A
G
D
-----
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
I
Q
L
C
L
E
A
---------------
Y
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
S
-
G
-----
G
----
E
S
IY-------------------------
G
A
P
---
F
K
D
E
F
H
S
R
L
R
F
N
-
R
R
G
----
L
V
A
M
A
N
A
-
G
----
S
H
D
N
G
S
Q
F
F
F
T
L
G
R
A
D
E
L
N
--------
N
--------
K
-
H
T
I
F
G
K
V
T
G
D
-
T
V
-
Y
N
M
L
R
-
L
S
E
V
D
I
---
D
-
D
----
D
--
E
R
P
-
H
N
P
H
K
I
K
S
C
E
V
--------------
26
PsiBlast_CBE
71.77
46%
-95
- C6 -
2ESL
7
PPIC_HUMAN
F:
[12-174]
----------
P
S
V
T
A
K
V
F
F
D
V
R
I
G
D
KDVGR
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
I
T
-----
T
-
G
-
D
-
G
-----
T
----
G
----------------------------
G
V
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
L
K
H
Y
GIG-
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
I
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
-----------------
5
PsiBlast_PDB
71.64
44%
-100
- C6 -
2OJU
1
PPIL3_HUMAN
A:
[8-160]
---------------
S
V
T
L
H
T
D
V
G
D
-----
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
---------------
A
S
N
Y
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
T
---
G
-
T
-
G
-
R
-
G
-----
G
N
S
I-
W
----------------------------
G
K
K
---
F
E
D
E
Y
S
E
Y
L
K
H
N
-
V
R
G
----
V
V
S
M
A
N
N
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
P
H
L
D
--------
M
--------
K
-
Y
T
V
F
G
K
V
I
D
G
L
E
T
-
L
D
E
L
E
K
L
P
--
V
N
---
E
-
K
----
T
--
Y
R
P
-
L
N
D
V
H
I
K
D
I
T
I
--------------
12
PsiBlast_PDB
71.32
41%
-100
- C6 -
2POE
4
?
A:
[23-173]
--------------------
T
N
Y
G
D
-----
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
L
A
L
S
----------
A
S
G
-----
Y
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
K
-
G
-----
G
----
E
S
IY-------------------------
G
R
Y
---
F
D
D
E
I
Y
P
E
L
K
Y
D
-
R
R
G
----
I
L
S
M
A
S
K
-
G
AKK-
P
N
T
N
G
S
Q
F
F
I
T
Y
S
S
L
P
Q
L
N
--------
G
--------
E
-
Y
V
I
F
G
K
L
I
D
G
----
F
E
T
L
N
T
L
E
N
C
P
S
---
D
-
K
----
S
--
H
K
P
-
I
D
E
I
I
I
K
D
I
V
I
--------------
11
PsiBlast_PDB
71.23
40%
-90
- C6 -
2HQ6
2
CWC27_HUMAN
A:
[19-178]
--------
S
E
P
P
T
N
G
K
V
L
L
K
T
T
A
G
D
-----
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
I
Q
L
C
L
E
A
---------------
Y
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
S
-
G
-----
G
----
E
S
IY-------------------------
G
A
P
---
F
K
D
E
F
H
S
R
L
R
F
N
-
R
R
G
----
L
V
A
M
A
N
A
-
G
----
S
H
D
N
G
S
Q
F
F
F
T
L
G
R
A
D
E
L
N
--------
N
--------
K
-
H
T
I
F
G
K
V
T
G
D
-
T
V
-
Y
N
M
L
R
-
L
S
E
V
D
I
---
D
-
D
----
D
--
E
R
P
-
H
N
P
H
K
I
K
S
C
E
V
--------------
107
HHSearch
71.18
44%
-91
- C6 -
2HQ6
2
CWC27_HUMAN
A:
[17-179]
------
R
G
S
E
P
P
T
N
G
K
V
L
L
K
T
T
A
G
D
-----
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
I
Q
L
C
L
---------------
E
A
Y
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
D
-
P
T
---
G
-
T
-
G
-
S
-
G
-----
G
----
E
S
IY-------------------------
G
A
P
---
F
K
D
E
F
H
S
R
L
R
F
N
-
R
R
G
----
L
V
A
M
A
N
A
-
G
----
S
H
D
N
G
S
Q
F
F
F
T
L
G
R
A
D
E
L
N
--------
N
--------
K
-
H
T
I
F
G
K
V
T
G
D
--
T
-
V
Y
N
M
L
R
L
S
E
V
D
I
---
D
-
D
----
D
--
E
R
P
-
H
N
P
H
K
I
K
S
C
E
V
L
-------------
29
PsiBlast_CBE
71.09
46%
-94
- C6 -
2ESL
6
PPIC_HUMAN
C:
[12-174]
----------
P
S
V
T
A
K
V
F
F
D
V
R
I
G
D
KDVGR
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
I
T
-----
T
-
G
-
D
-
G
-----
T
----
G
----------------------------
G
V
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
L
K
H
Y
GIG-
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
I
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
-----------------
45
PsiBlast_CBE
70.97
45%
-84
- C6 -
2POY
1
?
A:
[30-181]
-------------------
Q
T
P
A
G
R
-----
I
T
M
E
L
F
A
D
K
V
P
I
T
A
E
N
F
R
A
L
C
T
G
E
K
G
---
M
G
Q
S
G
K
P
L
--
C
Y
T
G
S
F
F
H
R
I
I
P
Q
F
M
I
Q
G
G
D
-
F
T
R--
G
-
D
-
G
-
T
-
G
-----
G
----
E
S
IY-------------------------
G
-
K
---
F
R
D
E
-
N
F
V
Y
T
H
D
-
A
P
F
----
L
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
V
P
C
P
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
L
---
E
G
-
M
E
V
V
K
S
I
E
K
C
G
S
---
Q
------
N
--
G
K
P
-
T
K
S
V
C
I
-------------------
43
PsiBlast_CBE
70.95
45%
-87
- C6 -
2POY
2
?
C:
[30-181]
-------------------
Q
T
P
A
G
R
-----
I
T
M
E
L
F
A
D
K
V
P
I
T
A
E
N
F
R
A
L
C
T
G
E
K
G
---
M
G
Q
S
G
K
P
L
--
C
Y
T
G
S
F
F
H
R
I
I
P
Q
F
M
I
Q
G
G
D
-
F
T
R--
G
-
D
-
G
-
T
-
G
-----
G
----
E
SIY-------------------------
G
-
K
---
F
R
D
E
-
N
F
V
Y
T
H
D
-
A
P
F
----
L
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
V
P
C
P
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
L
---
E
G
-
M
E
V
V
K
S
I
E
K
C
G
S
---
Q
------
N
--
G
K
P
-
T
K
S
V
C
I
-------------------
34
PsiBlast_CBE
69.77
45%
-89
- C6 -
1C5F
2
CYP1_BRUMA
M:
[21-170]
-----------------------
G
R
-----
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
L
M
L
C
T
G
M
A
--
G
T
G
K
I
S
G
K
P
L
--
H
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
-
F
T
K--
G
-
D
-
G
-
T
-
G
-----
G
----
E
SIY-------------------------
G
G
M
---
F
D
D
E
-
E
F
V
M
K
H
D
-
E
P
F
----
V
V
S
M
A
N
K
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
P
H
L
N
--------
N
--------
I
-
H
V
V
F
G
K
V
V
S
G
----
Q
E
V
V
T
K
I
E
Y
L
K
T
---
N
-
S
----
K
--
N
R
P
-
L
A
D
V
V
I
-------------------
27
PsiBlast_CBE
69.70
46%
-93
- C6 -
2ESL
6
PPIC_HUMAN
E:
[12-174]
----------
P
S
V
T
A
K
V
F
F
D
V
R
I
G
D
KDVGR
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
I
T
-----
T
-
G
-
D
-
G
-----
T
----
G
----------------------------
G
V
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
L
K
H
Y
GIG-
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
I
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
-----------------
30
PsiBlast_CBE
69.57
46%
-93
- C6 -
2ESL
6
PPIC_HUMAN
B:
[12-174]
----------
P
S
V
T
A
K
V
F
F
D
V
R
I
G
D
KDVGR
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
I
T
-----
T
-
G
-
D
-
G
-----
T
----
G
----------------------------
G
V
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
L
K
H
Y
GIG-
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
I
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
-----------------
17
PsiBlast_PDB
69.50
46%
-91
- C6 -
2ESL
6
PPIC_HUMAN
A:
[12-174]
----------
P
S
V
T
A
K
V
F
F
D
V
R
I
G
D
KDV
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
I
T
-----
T
-
G
-
D
-
G
-----
T
----
G
----------------------------
G
V
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
L
K
H
Y
GIG-
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
I
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
-----------------
36
PsiBlast_CBE
69.46
45%
-84
- C6 -
1C5F
1
CYP1_BRUMA
I:
[21-170]
-----------------------
G
R
-----
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
L
M
L
C
T
G
M
A
--
G
T
G
K
I
S
G
K
P
L
--
H
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
-
F
T
K--
G
-
D
-
G
-
T
-
G
-----
G
----
E
S
IY-------------------------
G
G
M
---
F
D
D
E
-
E
F
V
M
K
H
D
-
E
P
F
----
V
V
S
M
A
N
K
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
P
H
L
N
--------
N
--------
I
-
H
V
V
F
G
K
V
V
S
G
----
Q
E
V
V
T
K
I
E
Y
L
K
T
---
N
-
S
----
K
--
N
R
P
-
L
A
D
V
V
I
-------------------
39
PsiBlast_CBE
69.36
45%
-86
- C6 -
1C5F
1
CYP1_BRUMA
C:
[21-170]
-----------------------
G
R
-----
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
L
M
L
C
T
G
M
A
--
G
T
G
K
I
S
G
K
P
L
--
H
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
-
F
T
K--
G
-
D
-
G
-
T
-
G
-----
G
----
E
SIY-------------------------
G
G
M
---
F
D
D
E
-
E
F
V
M
K
H
D
-
E
P
F
----
V
V
S
M
A
N
K
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
P
H
L
N
--------
N
--------
I
-
H
V
V
F
G
K
V
V
S
G
----
Q
E
V
V
T
K
I
E
Y
L
K
T
---
N
-
S
----
K
--
N
R
P
-
L
A
D
V
V
I
-------------------
44
PsiBlast_CBE
68.95
45%
-81
- C6 -
2POY
2
?
B:
[30-181]
-------------------
Q
T
P
A
G
R
-----
I
T
M
E
L
F
A
D
K
V
P
I
T
A
E
N
F
R
A
L
C
T
G
E
K
G
---
M
G
Q
S
G
K
P
L
--
C
Y
T
G
S
F
F
H
R
I
I
P
Q
F
M
I
Q
G
G
D
-
F
T
R--
G
-
D
-
G
-
T
-
G
-----
G
----
E
S
IY-------------------------
G
-
K
---
F
R
D
E
-
N
F
V
Y
T
H
D
-
A
P
F
----
L
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
V
P
C
P
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
L
---
E
G
-
M
E
V
V
K
S
I
E
K
C
G
S
---
Q
------
N
--
G
K
P
-
T
K
S
V
C
I
-------------------
33
PsiBlast_CBE
68.95
45%
-82
- C6 -
1C5F
2
CYP1_BRUMA
O:
[21-170]
-----------------------
G
R
-----
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
L
M
L
C
T
G
M
A
--
G
T
G
K
I
S
G
K
P
L
--
H
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
-
F
T
K--
G
-
D
-
G
-
T
-
G
-----
G
----
E
SIY-------------------------
G
G
M
---
F
D
D
E
-
E
F
V
M
K
H
D
-
E
P
F
----
V
V
S
M
A
N
K
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
P
H
L
N
--------
N
--------
I
-
H
V
V
F
G
K
V
V
S
G
----
Q
E
V
V
T
K
I
E
Y
L
K
T
---
N
-
S
----
K
--
N
R
P
-
L
A
D
V
V
I
-------------------
28
PsiBlast_CBE
68.65
46%
-89
- C6 -
2ESL
6
PPIC_HUMAN
D:
[12-174]
----------
P
S
V
T
A
K
V
F
F
D
V
R
I
G
D
KDVGR
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
I
T
-----
T
-
G
-
D
-
G
-----
T
----
G
----------------------------
G
V
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
L
K
H
Y
GIG-
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
I
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
-----------------
41
PsiBlast_CBE
68.36
45%
-94
- C6 -
2CFE
3
?
A:
[16-162]
-----------------------
G
T
-----
I
K
F
K
L
F
D
D
V
V
P
K
T
A
A
N
F
R
A
L
C
T
G
E
K
G
F
G
------------
Y
A
G
S
H
F
H
R
V
I
P
D
F
M
L
Q
G
G
D
-
F
T
A--
G
-
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
A
K
---
F
A
D
E
-
N
F
Q
L
K
H
N
-
K
P
G
----
L
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
V
V
T
S
W
L
D
--------
G
--------
K
-
H
V
V
F
G
E
V
I
D
G
----
M
N
V
V
K
A
I
E
A
E
G
S
-----
G
----
S
--
G
K
P
-
R
S
R
I
E
I
A
K
C
G
V
C
-------------
35
PsiBlast_CBE
68.31
45%
-84
- C6 -
1C5F
2
CYP1_BRUMA
K:
[21-170]
-----------------------
G
R
-----
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
L
M
L
C
T
G
M
A
--
G
T
G
K
I
S
G
K
P
L
--
H
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
-
F
T
K--
G
-
D
-
G
-
T
-
G
-----
G
----
E
SIY-------------------------
G
G
M
---
F
D
D
E
-
E
F
V
M
K
H
D
-
E
P
F
----
V
V
S
M
A
N
K
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
P
H
L
N
--------
N
--------
I
-
H
V
V
F
G
K
V
V
S
G
----
Q
E
V
V
T
K
I
E
Y
L
K
T
---
N
-
S
----
K
--
N
R
P
-
L
A
D
V
V
I
-------------------
38
PsiBlast_CBE
68.13
45%
-80
- C6 -
1C5F
3
CYP1_BRUMA
E:
[21-170]
-----------------------
G
R
-----
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
L
M
L
C
T
G
M
A
--
G
T
G
K
I
S
G
K
P
L
--
H
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
-
F
T
K--
G
-
D
-
G
-
T
-
G
-----
G
----
E
SIY-------------------------
G
G
M
---
F
D
D
E
-
E
F
V
M
K
H
D
-
E
P
F
----
V
V
S
M
A
N
K
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
P
H
L
N
--------
N
--------
I
-
H
V
V
F
G
K
V
V
S
G
----
Q
E
V
V
T
K
I
E
Y
L
K
T
---
N
-
S
----
K
--
N
R
P
-
L
A
D
V
V
I
-------------------
37
PsiBlast_CBE
68.00
45%
-86
- C6 -
1C5F
2
CYP1_BRUMA
G:
[21-170]
-----------------------
G
R
-----
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
L
M
L
C
T
G
M
A
--
G
T
G
K
I
S
G
K
P
L
--
H
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
-
F
T
K--
G
-
D
-
G
-
T
-
G
-----
G
----
E
SIY-------------------------
G
G
M
---
F
D
D
E
-
E
F
V
M
K
H
D
-
E
P
F
----
V
V
S
M
A
N
K
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
P
H
L
N
--------
N
--------
I
-
H
V
V
F
G
K
V
V
S
G
----
Q
E
V
V
T
K
I
E
Y
L
K
T
---
N
-
S
----
K
--
N
R
P
-
L
A
D
V
V
I
-------------------
20
PsiBlast_PDB
67.77
45%
-85
- C6 -
1C5F
1
CYP1_BRUMA
A:
[21-170]
-----------------------
G
R
-----
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
L
M
L
C
T
G
M
A
--
G
T
G
K
I
S
G
K
P
L
--
H
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
-
F
T
K--
G
-
D
-
G
-
T
-
G
-----
G
----
E
S
IY-------------------------
G
G
M
---
F
D
D
E
-
E
F
V
M
K
H
D
-
E
P
F
----
V
V
S
M
A
N
K
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
P
H
L
N
--------
N
--------
I
-
H
V
V
F
G
K
V
V
S
G
----
Q
E
V
V
T
K
I
E
Y
L
K
T
---
N
-
S
----
K
--
N
R
P
-
L
A
D
V
V
I
-------------------
42
PsiBlast_CBE
67.68
47%
-94
- C6 -
1H0P
1
CYP5_CAEEL
A:
[21-162]
-----------------------
G
R
-----
I
V
I
G
L
F
G
K
T
V
P
K
T
A
T
N
F
I
E
L
A
K
K
------------
P
K
G
E
G
Y
P
G
S
K
F
H
R
V
I
A
D
F
M
I
Q
G
G
D
-
F
T
R--
G
-
D
-
G
-
T
-
G
-----
G
----
R
S
IY-------------------------
G
E
K
---
F
A
D
E
-
N
F
K
L
K
H
Y
-
G
A
G
----
W
L
S
M
A
N
A
-
G
----
A
D
T
N
G
S
Q
F
F
I
T
T
V
K
T
P
W
L
D
--------
G
--------
R
-
H
V
V
F
G
K
I
L
---
E
G
-
M
D
V
V
R
K
I
E
Q
T
E
K
---
L
-
P
----
G
--
D
R
P
-
K
Q
D
V
I
I
-------------------
61
PsiBlast_CBE
67.61
44%
-99
- C6 -
3K2C
3
CYPH_ENCCU
B:
[42-172]
-----------------------
G
R
-----
I
V
M
K
L
E
D
D
I
V
P
K
T
A
K
N
F
R
T
L
C
E
R
------------
P
K
G
E
G
Y
K
G
S
T
F
H
R
I
I
P
G
F
M
V
Q
G
G
D
-
Y
T
AHN
G
-
T
-
G
G
R
-
S
-----
I
----
Y
----------------------------
G
E
K
---
F
P
D
E
-
N
F
E
L
K
H
T
-
K
E
G
----
I
L
S
M
A
N
C
-
G
----
A
H
T
N
G
S
Q
F
F
I
T
L
G
K
T
Q
W
L
D
--------
E
--------
K
-
H
V
V
F
G
E
V
V
---
E
G
-
M
D
V
V
H
K
I
A
K
Y
G
S
---
E
--------------------------------------
68
PsiBlast_CBE
67.59
40%
-96
- C6 -
4N1S
2
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
100
PsiBlast_CBE
67.46
40%
-100
- C6 -
2RMB
3
PPIA_HUMAN
K:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
47
PsiBlast_CBE
67.37
46%
-88
- C6 -
4JJM
2
?
A:
[21-168]
-----------------------
G
R
-----
I
V
M
E
L
F
A
D
V
T
P
R
T
A
E
N
F
R
A
L
C
T
G
E
K
G
I
G
K
---
S
G
K
P
L
--
H
Y
K
G
S
S
F
H
R
V
I
P
G
F
M
C
Q
G
G
D
-
F
T
A--
G
-
N
-
G
-
T
-
G
-----
G
----
E
S
IY-------------------------
G
S
K
---
F
A
D
E
N
F
V
K
-
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
G
T
N
G
S
Q
F
F
V
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
Q
V
V
---
E
G
-
M
D
V
V
K
A
I
E
K
V
G
S
---
S
------
S
--
G
R
T
-
N
K
P
V
V
I
-------------------
62
PsiBlast_CBE
67.08
44%
-98
- C6 -
3K2C
2
CYPH_ENCCU
A:
[42-172]
-----------------------
G
R
-----
I
V
M
K
L
E
D
D
I
V
P
K
T
A
K
N
F
R
T
L
C
E
R
------------
P
K
G
E
G
Y
K
G
S
T
F
H
R
I
I
P
G
F
M
V
Q
G
G
D
-
Y
T
AHN
G
-
T
-
G
G
R
-
S
-----
I
----
Y
----------------------------
G
E
K
---
F
P
D
E
-
N
F
E
L
K
H
T
-
K
E
G
----
I
L
S
M
A
N
C
-
G
----
A
H
T
N
G
S
Q
F
F
I
T
L
G
K
T
Q
W
L
D
--------
E
--------
K
-
H
V
V
F
G
E
V
V
---
E
G
-
M
D
V
V
H
K
I
A
K
Y
G
S
---
E
--------------------------------------
77
PsiBlast_CBE
66.69
40%
-101
- C6 -
3ODL
3
PPIA_HUMAN
O:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
66
PsiBlast_CBE
66.48
40%
-92
- C6 -
3RDD
1
PPIA_HUMAN
A:
[37-177]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
122
HHSearch
66.46
39%
-103
- C6 -
3S6M
3
?
A:
[3-167]
-------------
G
S
M
V
E
L
H
T
N
H
G
V
-----
I
K
L
E
L
D
E
A
K
A
P
K
T
V
E
N
F
L
N
Y
V
K
---------------
K
G
H
Y
D
G
T
I
F
H
R
V
I
N
G
F
M
I
Q
G
G
G
-
F
E
---
P
-
G
-
L
-
K
Q
K
-----
P
----
T
----------------------------
D
A
P
---
I
A
N
E
A
N
N
G
L
K
N
--
D
T
Y
----
T
I
A
M
A
R
T
N
D
----
P
H
S
A
T
A
Q
F
F
I
N
V
N
D
N
E
F
L
N
--------
H
SSPTPQGW
G
-
Y
A
V
F
G
K
V
V
E
---
G
-
Q
D
I
V
D
K
I
K
A
V
K
T
---
G
-
S
-----HQ
D
V
P
-
N
D
D
V
V
I
E
K
A
V
V
V
-------------
94
PsiBlast_CBE
66.42
40%
-99
- C6 -
3ODI
3
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
74
PsiBlast_CBE
66.37
40%
-97
- C6 -
4IPZ
3
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
-
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
99
PsiBlast_CBE
66.35
40%
-100
- C6 -
2RMB
3
PPIA_HUMAN
M:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
102
PsiBlast_CBE
66.30
40%
-98
- C6 -
2RMB
3
PPIA_HUMAN
G:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
91
PsiBlast_CBE
66.22
40%
-101
- C6 -
3ODI
3
PPIA_HUMAN
G:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
101
PsiBlast_CBE
66.20
40%
-98
- C6 -
2RMB
3
PPIA_HUMAN
I:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
24
PsiBlast_CBE
66.12
46%
-90
- C6 -
2RMC
1
PPIC_MOUSE
E:
[22-166]
-----------------------
G
R
-----
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
ARD
G
-
T
-
G
-------------------------------------------
G
M
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
-
L
K
H
YGIG
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
L
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
D
C
T
I
V
N
S
-----------------
82
PsiBlast_CBE
66.00
40%
-98
- C6 -
3ODL
3
PPIA_HUMAN
E:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
40
PsiBlast_CBE
65.89
44%
-87
- C6 -
1CYN
1
PPIB_HUMAN
A:
[20-161]
-----------------------
G
R
-----
V
I
F
G
L
F
G
K
T
V
P
K
T
V
D
N
F
V
A
L
A
T
G
E
K
G
F
G
Y
K
N
S
K
------------
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
R--
G
-
D
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
R
---
F
P
D
E
-
N
F
K
L
K
H
Y
-
G
P
G
----
W
V
S
M
A
N
A
-
G
----
K
D
T
N
G
S
Q
F
F
I
T
T
V
K
T
A
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
L
---
E
G
-
M
E
V
V
R
K
V
E
S
T
K
T
---
D
-
S
----
R
--
D
K
P
-
L
K
D
V
I
I
-------------------
46
PsiBlast_CBE
65.83
46%
-84
- C6 -
4JJM
1
?
B:
[21-168]
-----------------------
G
R
-----
I
V
M
E
L
F
A
D
V
T
P
R
T
A
E
N
F
R
A
L
C
T
G
E
K
G
I
G
K
---
S
G
K
P
L
--
H
Y
K
G
S
S
F
H
R
V
I
P
G
F
M
C
Q
G
G
D
-
F
T
A--
G
-
N
-
G
-
T
-
G
-----
G
----
E
SIY-------------------------
G
S
K
---
F
A
D
E
N
F
V
K
-
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
G
T
N
G
S
Q
F
F
V
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
Q
V
V
---
E
G
-
M
D
V
V
K
A
I
E
K
V
G
S
---
S
------
S
--
G
R
T
-
N
K
P
V
V
I
-------------------
75
PsiBlast_CBE
65.77
40%
-100
- C6 -
3ODL
3
PPIA_HUMAN
S:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
93
PsiBlast_CBE
65.76
40%
-101
- C6 -
3ODI
3
PPIA_HUMAN
C:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
84
PsiBlast_CBE
65.65
40%
-97
- C6 -
3ODL
3
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
81
PsiBlast_CBE
65.62
40%
-97
- C6 -
3ODL
3
PPIA_HUMAN
G:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
78
PsiBlast_CBE
65.62
40%
-98
- C6 -
3ODL
3
PPIA_HUMAN
M:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
80
PsiBlast_CBE
65.60
40%
-97
- C6 -
3ODL
3
PPIA_HUMAN
I:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
98
PsiBlast_CBE
65.55
40%
-96
- C6 -
2RMB
3
PPIA_HUMAN
O:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
25
PsiBlast_CBE
65.42
46%
-92
- C6 -
2RMC
1
PPIC_MOUSE
C:
[22-166]
-----------------------
G
R
-----
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
ARD
G
-
T
-
G
-------------------------------------------
G
M
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
-
L
K
H
YGIG
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
L
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
D
C
T
I
V
N
S
-----------------
16
PsiBlast_PDB
65.20
46%
-90
- C6 -
2RMC
1
PPIC_MOUSE
A:
[22-166]
-----------------------
G
R
-----
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
ARD
G
-
T
-
G
-------------------------------------------
G
M
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
-
L
K
H
YGIG
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
L
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
D
C
T
I
V
N
S
-----------------
88
PsiBlast_CBE
65.14
40%
-99
- C6 -
3ODI
3
PPIA_HUMAN
M:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
116
HHSearch
65.11
40%
-102
- C6 -
1LOP
1
PPIB_ECOLI
A:
[2-163]
----------------
V
T
F
H
T
N
H
G
D
-----
I
V
I
K
T
F
D
D
K
A
P
E
T
V
K
N
F
L
D
Y
C
R
---------------
E
G
F
Y
N
N
T
I
F
H
R
V
I
N
G
F
M
I
Q
G
G
G
-
F
E
---
P
-
G
M
K
-
Q
-
K
-----
A
----
T
----------------------------
K
E
P
---
I
K
N
E
A
N
N
G
L
K
N
--
T
R
G
----
T
L
A
M
A
R
T
Q
A
----
P
H
S
A
T
A
Q
F
F
I
N
V
V
D
N
D
F
L
N
FSGESLQG
W
--------
G
-
Y
C
V
F
A
E
V
V
D
---
G
-
M
D
E
V
D
K
I
K
G
V
A
T
---
G
-
R
S
GMH
Q
--
D
V
P
-
K
E
D
V
I
I
E
S
V
T
V
S
-------------
76
PsiBlast_CBE
65.10
40%
-97
- C6 -
3ODL
3
PPIA_HUMAN
Q:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
73
PsiBlast_CBE
65.05
40%
-94
- C6 -
4N1N
1
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
96
PsiBlast_CBE
65.03
40%
-96
* C6 *
2RMB
3
PPIA_HUMAN
S:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
89
PsiBlast_CBE
64.99
40%
-100
- C6 -
3ODI
3
PPIA_HUMAN
K:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
69
PsiBlast_CBE
64.92
40%
-94
- C6 -
4N1R
1
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
71
PsiBlast_CBE
64.91
40%
-99
- C6 -
4N1P
3
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
67
PsiBlast_CBE
64.86
40%
-92
- C6 -
4N1M
2
PPIA_HUMAN
A:
[21-161]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
85
PsiBlast_CBE
64.80
40%
-97
- C6 -
3ODI
3
PPIA_HUMAN
S:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
72
PsiBlast_CBE
64.76
40%
-92
- C6 -
4N1O
5
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
23
PsiBlast_CBE
64.70
46%
-89
- C6 -
2RMC
1
PPIC_MOUSE
G:
[22-166]
-----------------------
G
R
-----
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
Y
G
------------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
ARD
G
-
T
-
G
-------------------------------------------
G
M
S
---
I
Y
G
E
T
F
P
D
E
N
F
K
-
L
K
H
YGIG
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
L
D
G
-
M
T
---
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
L
T
D
C
T
I
V
N
S
-----------------
83
PsiBlast_CBE
64.69
40%
-98
- C6 -
3ODL
3
PPIA_HUMAN
C:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
87
PsiBlast_CBE
64.61
40%
-95
- C6 -
3ODI
3
PPIA_HUMAN
O:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
70
PsiBlast_CBE
64.61
40%
-93
- C6 -
4N1Q
1
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
79
PsiBlast_CBE
64.41
40%
-97
- C6 -
3ODL
3
PPIA_HUMAN
K:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
90
PsiBlast_CBE
64.12
40%
-95
- C6 -
3ODI
3
PPIA_HUMAN
I:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
31
PsiBlast_CBE
64.09
47%
-86
- C6 -
3EOV
1
?
B:
[26-166]
-----------------------
G
R
-----
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
R
Q
L
C
T
G
E
H
G
F
G
------------
Y
K
D
S
I
F
H
R
V
I
Q
N
F
M
I
Q
G
G
D
-
F
T
---
N
F
D
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
A
D
E
N
L
N
V
K
H
F
V
-
G
A
------
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
A
P
T
P
W
L
D
--------
G
--------
R
-
H
V
V
F
G
K
V
L
D
G
----
M
D
V
V
L
R
I
E
K
T
K
T
---
N
-
S
----
H
--
D
R
P
-
V
K
P
V
K
I
-------------------
86
PsiBlast_CBE
64.03
40%
-98
- C6 -
3ODI
3
PPIA_HUMAN
Q:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
97
PsiBlast_CBE
63.98
40%
-98
- C6 -
2RMB
3
PPIA_HUMAN
Q:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
92
PsiBlast_CBE
63.77
40%
-95
- C6 -
3ODI
3
PPIA_HUMAN
E:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
124
Fugue
63.57
42%
-77
- C6 -
2RMC
1
PPIC_MOUSE
A:
[1-182]
--
K
R
G
P
S
V
T
D
K
V
F
F
D
V
R
I
G
D
K
D
V
G
R
-----
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
V
A
L
A
T
G
E
K
G
--------
Y
----
G
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
A--
R
-
D
-
G
-
T
-
G
-----
G
----
M
S
IY-------------------------
G
E
T
---
F
P
D
E
N
F
K
L
K
H
Y
G
-
I
G
W
----
V
S
M
A
N
A
--
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
T
W
L
D
--------
G
---------K
H
V
V
F
G
K
V
L
D
---
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
---
D
-
G
----
H
--
D
R
P
-
L
T
D
C
T
I
V
N
S
G
K
I
D
V
K
T
P
F
V
VEVPDW
32
PsiBlast_CBE
62.14
47%
-86
- C6 -
3EOV
1
?
A:
[26-166]
-----------------------
G
R
-----
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
R
Q
L
C
T
G
E
H
G
F
G
------------
Y
K
D
S
I
F
H
R
V
I
Q
N
F
M
I
Q
G
G
D
-
F
T
---
N
F
D
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
A
D
E
N
L
N
V
K
H
F
V
-
G
A
------
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
T
T
A
P
T
P
W
L
D
--------
G
--------
R
-
H
V
V
F
G
K
V
L
D
G
----
M
D
V
V
L
R
I
E
K
T
K
T
---
N
-
S
----
H
--
D
R
P
-
V
K
P
V
K
I
-------------------
49
PsiBlast_CBE
61.30
45%
-77
- C6 -
1XQ7
1
?
B:
[20-160]
-----------------------
G
R
-----
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
K
Q
L
A
S
G
------
E
N
G
F
G
------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
-
F
T
---
N
F
D
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
T
R
---
F
D
D
E
N
L
K
I
K
H
F
V
-
G
A
------
V
S
M
A
N
A
-
G
----
P
N
S
N
G
S
Q
F
F
V
T
T
A
P
T
P
W
L
D
--------
G
--------
R
-
H
V
V
F
G
K
V
V
---
E
G
-
M
D
V
V
K
K
V
E
N
T
K
T
---
G
-
L
----
N
--
D
K
P
-
K
K
A
V
K
I
-------------------
48
PsiBlast_CBE
60.46
45%
-75
- C6 -
1XQ7
1
?
C:
[20-160]
-----------------------
G
R
-----
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
K
Q
L
A
S
G
------
E
N
G
F
G
------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
-
F
T
---
N
F
D
-
G
-
T
-
G
-----
G
----
K
SIY-------------------------
G
T
R
---
F
D
D
E
N
L
K
I
K
H
F
V
-
G
A
------
V
S
M
A
N
A
-
G
----
P
N
S
N
G
S
Q
F
F
V
T
T
A
P
T
P
W
L
D
--------
G
--------
R
-
H
V
V
F
G
K
V
V
---
E
G
-
M
D
V
V
K
K
V
E
N
T
K
T
---
G
-
L
----
N
--
D
K
P
-
K
K
A
V
K
I
-------------------
95
PsiBlast_CBE
60.18
40%
-94
- C6 -
3CYS
1
PPIA_HUMAN
A:
[18-158]
-----------------------
G
R
-----
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G
E
K
G
F
G
------------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
-
F
T
---
R
H
N
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
E
K
---
F
E
D
E
-
N
F
I
L
K
H
T
-
G
P
G
----
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
--------
G
--------
K
-
H
V
V
F
G
K
V
--
K
-
E
G
-
M
N
I
V
E
A
M
E
R
F
G
S
---
R
------
N
--
G
K
T
-
S
K
K
I
T
I
-------------------
50
PsiBlast_CBE
59.61
45%
-79
- C6 -
1XQ7
1
?
A:
[20-160]
-----------------------
G
R
-----
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
K
Q
L
A
S
G
------
E
N
G
F
G
------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
-
F
T
---
N
F
D
-
G
-
T
-
G
-----
G
----
K
S
IY-------------------------
G
T
R
---
F
D
D
E
N
L
K
I
K
H
F
V
-
G
A
------
V
S
M
A
N
A
-
G
----
P
N
S
N
G
S
Q
F
F
V
T
T
A
P
T
P
W
L
D
--------
G
--------
R
-
H
V
V
F
G
K
V
V
---
E
G
-
M
D
V
V
K
K
V
E
N
T
K
T
---
G
-
L
----
N
--
D
K
P
-
K
K
A
V
K
I
-------------------