@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0016c: (2016-04-18 )
MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVLLDEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKGAVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETYPPGSTFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFVKSCNTAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGMTSIGQKDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVSPQVAAKLTELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQAPKVAVAVLVENGADRLSATGGALAAPIGRAVIEAALQGEP
Atome Classification :
(20 SA)
.........10........20........30........40........50....-..-..60........70........80........90...-.....100..--.....110------.........120.......130-.........140.......150..--.--....160.......170.......180.......190.......200.......210.......220.......230.......240.-....-..250.......260.....-..270.......280.......290.......300.......---------------310--.......-320..--.--.--..-----.330.......340-----------.........350.......360.......370.......380.......390.......400......-----------.410---------..-...-----....420.......430-....-.------....440----.........450.......460........470.......480.......490-----------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNAS
L
R
R
I
S
V
T
V
M
A
L
I
V
L
L
L
L
N
A
T
M
T
Q
V
F
TADGLRADPRN
Q
R
V
L
L
D
E
Y
S
R
QRG
Q
I
-TA-G
G
Q
L
L
A
Y
S
VATDG
R
F
R
F
L
R
VYPNP
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-YSS
T
A
L
E
RAE--DPILNG--------S
D
R
R
L
F
G
R
R
L
A
D
F
FTGRDPR---GGNVDTTINP
R
I
Q
Q
A
G
W
D
A
M
Q
QGC--Y--GPCK
G
A
V
V
A
LEPST
G
K
I
L
A
L
V
SSPSYDPNLLASHNP
E
V
Q
A
Q
A
W
Q
RLGDNPASPLTNRAISETYPPGS
T
F
K
V
I
T
T
A
A
A
LAAGATETEQL-TAAP-TIPLPGST
A
Q
LENYGGAPCG-DEP
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
LGIRT
G
A
D
A
L
R
S
M
A
R
AFGLDS---------------PPR--PT
P
L
Q
V
A
-ESTVG--P--I--PD-----SAALGMTSIGQK-------------D
V
A
L
TPLAN
A
E
I
A
A
T
IANG
G
I
T
M
R
P
Y
L
V
GSLKGPDLANISTTVG
Y
Q
Q
RRAV
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
E
K
-----------
V
A
-----------
Q
Q
-KGA-----IP
G
V
Q
I
ASKTGTAEH---GTDP-R------HTPP
H
------
A
W
Y
I
A
FAPAQAP
K
V
A
V
A
V
L
VE-NGA
D
R
LSATGG
A
L
A
A
P
I
G
R
A
V
I
E
A
A
LQGEP------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.80
99%
-78
- C1 -
3UN7
-
PBPA_MYCTU
A:
[48-488]
-----------------------------------------------
Y
S
R
Q
R
G
Q
I
-
T
A
-
G
G
Q
L
L
A
Y
S
V
A
T
D
G
R
F
R
F
L
R
V
Y
P
N
P
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-
Y
S
S
T
A
L
E
R
A
E
--
D
P
I
L
N
G
--------
S
D
R
R
L
F
G
R
R
L
A
D
F
F
T
G
R
D
P
R
---
G
G
N
V
D
T
T
I
N
P
R
I
Q
Q
A
G
W
D
A
M
Q
Q
G
C
--
Y
--
G
P
C
K
G
A
V
V
A
L
E
P
S
T
G
K
I
L
A
L
V
S
S
P
S
Y
D
P
N
L
L
A
S
H
N
P
E
V
Q
A
Q
A
W
Q
R
L
G
D
N
P
A
S
P
L
T
N
R
A
I
S
E
T
Y
P
P
G
S
T
F
K
V
I
T
T
A
A
A
L
A
A
G
A
T
E
T
E
Q
L
-
T
A
A
P
-
T
I
P
L
P
G
S
T
A
Q
L
E
N
Y
G
G
A
P
C
G
-
D
E
P
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
L
G
I
R
T
G
A
D
A
L
R
S
M
A
R
A
F
G
L
D
S
---------------
P
P
R
--
P
T
P
L
Q
V
A
-
E
S
T
V
G
--
P
--
I
--
P
D
-----
S
A
A
L
G
M
T
S
I
G
Q
K
-------------
D
V
A
L
T
P
L
A
N
A
E
I
A
A
T
I
A
N
G
G
I
T
M
R
P
Y
L
V
G
S
L
K
G
P
D
L
A
N
I
S
T
T
V
R
Y
Q
Q
R
R
A
V
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
E
K
-----------
V
-------------
Q
-
K
G
A
-----
I
P
G
V
Q
I
A
S
K
T
G
T
A
E
H
---
G
T
D
P
-
R
------
H
T
P
P
H
------
A
W
Y
I
A
F
A
P
A
Q
A
P
K
V
A
V
A
V
L
V
E
-
N
G
A
D
R
L
S
A
T
G
G
A
L
A
A
P
I
G
R
A
V
I
E
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
96.25
99%
-77
- C1 -
3UPP
1
PBPA_MYCTU
A:
[15-459]
-------------------------------------------
L
L
D
E
Y
S
R
Q
R
G
Q
I
-
T
A
-
G
G
Q
L
L
A
Y
S
V
A
T
D
G
R
F
R
F
L
R
V
Y
P
N
P
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-
Y
S
S
T
A
L
E
R
A
E
--
D
P
I
L
N
G
--------
S
D
R
R
L
F
G
R
R
L
A
D
F
F
T
G
R
D
P
R
---
G
G
N
V
D
T
T
I
N
P
R
I
Q
Q
A
G
W
D
A
M
Q
Q
G
C
--
Y
--
G
P
C
K
G
A
V
V
A
L
E
P
S
T
G
K
I
L
A
L
V
S
S
P
S
Y
D
P
N
L
L
A
S
H
N
P
E
V
Q
A
Q
A
W
Q
R
L
G
D
N
P
A
S
P
L
T
N
R
A
I
S
E
T
Y
P
P
G
S
T
F
K
V
I
T
T
A
A
A
L
A
A
G
A
T
E
T
E
Q
L
-
T
A
A
P
-
T
I
P
L
P
G
S
T
A
Q
L
E
N
Y
G
G
A
P
C
G
-
D
E
P
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
L
G
I
R
T
G
A
D
A
L
R
S
M
A
R
A
F
G
L
D
S
---------------
P
P
R
--
P
T
P
L
Q
V
A
-
E
S
T
V
G
--
P
--
I
--
P
D
-----
S
A
A
L
G
M
T
S
I
G
Q
K
-------------
D
V
A
L
T
P
L
A
N
A
E
I
A
A
T
I
A
N
G
G
I
T
M
R
P
Y
L
V
G
S
L
K
G
P
D
L
A
N
I
S
T
T
V
R
Y
Q
Q
R
R
A
V
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
E
K
-----------
V
A
-----------
Q
Q
-
K
G
A
-----
I
P
G
V
Q
I
A
S
K
T
G
T
A
E
H
---
G
T
D
P
-
R
------
H
T
P
P
H
------
A
W
Y
I
A
F
A
P
A
Q
A
P
K
V
A
V
A
V
L
V
E
-
N
G
A
D
R
L
S
A
T
G
G
A
L
A
A
P
I
G
R
A
V
I
E
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.20
99%
-82
- C1 -
3UPN
1
PBPA_MYCTU
A:
[15-459]
-------------------------------------------
L
L
D
E
Y
S
R
Q
R
G
Q
I
-
T
A
-
G
G
Q
L
L
A
Y
S
V
A
T
D
G
R
F
R
F
L
R
V
Y
P
N
P
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-
Y
S
S
T
A
L
E
R
A
E
--
D
P
I
L
N
G
--------
S
D
R
R
L
F
G
R
R
L
A
D
F
F
T
G
R
D
P
R
---
G
G
N
V
D
T
T
I
N
P
R
I
Q
Q
A
G
W
D
A
M
Q
Q
G
C
--
Y
--
G
P
C
K
G
A
V
V
A
L
E
P
S
T
G
K
I
L
A
L
V
S
S
P
S
Y
D
P
N
L
L
A
S
H
N
P
E
V
Q
A
Q
A
W
Q
R
L
G
D
N
P
A
S
P
L
T
N
R
A
I
S
E
T
Y
P
P
G
S
T
F
K
V
I
T
T
A
A
A
L
A
A
G
A
T
E
T
E
Q
L
-
T
A
A
P
-
T
I
P
L
P
G
S
T
A
Q
L
E
N
Y
G
G
A
P
C
G
-
D
E
P
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
L
G
I
R
T
G
A
D
A
L
R
S
M
A
R
A
F
G
L
D
S
---------------
P
P
R
--
P
T
P
L
Q
V
A
-
E
S
T
V
G
--
P
--
I
--
P
D
-----
S
A
A
L
G
M
T
S
I
G
Q
K
-------------
D
V
A
L
T
P
L
A
N
A
E
I
A
A
T
I
A
N
G
G
I
T
M
R
P
Y
L
V
G
S
L
K
G
P
D
L
A
N
I
S
T
T
V
R
Y
Q
Q
R
R
A
V
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
E
K
-----------
V
A
-----------
Q
Q
-
K
G
A
-----
I
P
G
V
Q
I
A
S
K
T
G
T
A
E
H
---
G
T
-----------
T
P
P
H
------
A
W
Y
I
A
F
A
P
A
Q
A
P
K
V
A
V
A
V
L
V
E
-
N
G
A
D
R
------
A
L
A
A
P
I
G
R
A
V
I
E
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.92
99%
-80
- C1 -
3UPP
1
PBPA_MYCTU
B:
[21-459]
-------------------------------------------------
R
Q
R
G
Q
I
-
T
A
-
G
G
Q
L
L
A
Y
S
V
A
T
D
G
R
F
R
F
L
R
V
Y
P
N
P
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-
Y
S
S
T
A
L
E
R
A
E
--
D
P
I
L
N
G
--------
S
D
R
R
L
F
G
R
R
L
A
D
F
F
T
G
R
D
P
R
---
G
G
N
V
D
T
T
I
N
P
R
I
Q
Q
A
G
W
D
A
M
Q
Q
G
C
--
Y
--
G
P
C
K
G
A
V
V
A
L
E
P
S
T
G
K
I
L
A
L
V
S
S
P
S
Y
D
P
N
L
L
A
S
H
N
P
E
V
Q
A
Q
A
W
Q
R
L
G
D
N
P
A
S
P
L
T
N
R
A
I
S
E
T
Y
P
P
G
S
T
F
K
V
I
T
T
A
A
A
L
A
A
G
A
T
E
T
E
Q
L
-
T
A
A
P
-
T
I
P
L
P
G
S
T
A
Q
L
E
N
Y
G
G
A
P
C
G
-
D
E
P
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
L
G
I
R
T
G
A
D
A
L
R
S
M
A
R
A
F
G
L
D
S
---------------
P
P
R
--
P
T
P
L
Q
V
A
-
E
S
T
V
G
--
P
--
I
--
P
D
-----
S
A
A
L
G
M
T
S
I
G
Q
K
-------------
D
V
A
L
T
P
L
A
N
A
E
I
A
A
T
I
A
N
G
G
I
T
M
R
P
Y
L
V
G
S
L
K
G
P
D
L
A
N
I
S
T
T
V
R
Y
Q
Q
R
R
A
V
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
E
K
-----------
V
A
-----------
Q
Q
-
K
G
A
-----
I
P
G
V
Q
I
A
S
K
T
G
T
A
E
H
---
G
T
D
P
-
R
------
H
T
P
P
H
------
A
W
Y
I
A
F
A
P
A
Q
A
P
K
V
A
V
A
V
L
V
E
-
N
G
A
D
R
L
S
A
T
G
G
A
L
A
A
P
I
G
R
A
V
I
E
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
95.36
99%
-76
- C1 -
3UPN
1
PBPA_MYCTU
B:
[17-459]
---------------------------------------------
D
E
Y
S
R
Q
R
G
Q
I
-
T
A
-
G
G
Q
L
L
A
Y
S
V
A
T
D
G
R
F
R
F
L
R
V
Y
P
N
P
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-
Y
S
S
T
A
L
E
R
A
E
--
D
P
I
L
N
G
--------
S
D
R
R
L
F
G
R
R
L
A
D
F
F
T
G
R
D
P
R
---
G
G
N
V
D
T
T
I
N
P
R
I
Q
Q
A
G
W
D
A
M
Q
Q
G
C
--
Y
--
G
P
C
K
G
A
V
V
A
L
E
P
S
T
G
K
I
L
A
L
V
S
S
P
S
Y
D
P
N
L
L
A
S
H
N
P
E
V
Q
A
Q
A
W
Q
R
L
G
D
N
P
A
S
P
L
T
N
R
A
I
S
E
T
Y
P
P
G
S
T
F
K
V
I
T
T
A
A
A
L
A
A
G
A
T
E
T
E
Q
L
-
T
A
A
P
-
T
I
P
L
P
G
S
T
A
Q
L
E
N
Y
G
G
A
P
C
G
-
D
E
P
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
L
G
I
R
T
G
A
D
A
L
R
S
M
A
R
A
F
G
L
D
S
---------------
P
P
R
--
P
T
P
L
Q
V
A
-
E
S
T
V
G
--
P
--
I
--
P
D
-----
S
A
A
L
G
M
T
S
I
G
Q
K
-------------
D
V
A
L
T
P
L
A
N
A
E
I
A
A
T
I
A
N
G
G
I
T
M
R
P
Y
L
V
G
S
L
K
G
P
D
L
A
N
I
S
T
T
V
R
Y
Q
Q
R
R
A
V
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
E
K
-----------
V
A
-----------
Q
Q
-
K
G
A
-----
I
P
G
V
Q
I
A
S
K
T
G
T
A
E
H
-----------------
P
P
H
------
A
W
Y
I
A
F
A
P
A
Q
A
P
K
V
A
V
A
V
L
V
E
-
N
G
A
D
R
L
S
A
T
G
G
A
L
A
A
P
I
G
R
A
V
I
E
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.10
99%
-77
- C1 -
3UPO
1
PBPA_MYCTU
A:
[18-459]
----------------------------------------------
E
Y
S
R
Q
R
G
Q
I
-
T
A
-
G
G
Q
L
L
A
Y
S
V
A
T
D
G
R
F
R
F
L
R
V
Y
P
N
P
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-
Y
S
S
T
A
L
E
R
A
E
--
D
P
I
L
N
G
--------
S
D
R
R
L
F
G
R
R
L
A
D
F
F
T
G
R
D
P
R
---
G
G
N
V
D
T
T
I
N
P
R
I
Q
Q
A
G
W
D
A
M
Q
Q
G
C
--
Y
--
G
P
C
K
G
A
V
V
A
L
E
P
S
T
G
K
I
L
A
L
V
S
S
P
S
Y
D
P
N
L
L
A
S
H
N
P
E
V
Q
A
Q
A
W
Q
R
L
G
D
N
P
A
S
P
L
T
N
R
A
I
S
E
T
Y
P
P
G
S
T
F
K
V
I
T
T
A
A
A
L
A
A
G
A
T
E
T
E
Q
L
-
T
A
A
P
-
T
I
P
L
P
G
S
T
A
Q
L
E
N
Y
G
G
A
P
C
G
-
D
E
P
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
L
G
I
R
T
G
A
D
A
L
R
S
M
A
R
A
F
G
L
D
S
---------------
P
P
R
--
P
T
P
L
Q
V
A
-
E
S
T
V
G
--
P
--
I
--
P
D
-----
S
A
A
L
G
M
T
S
I
G
Q
K
-------------
D
V
A
L
T
P
L
A
N
A
E
I
A
A
T
I
A
N
G
G
I
T
M
R
P
Y
L
V
G
S
L
K
G
P
D
L
A
N
I
S
T
T
V
R
Y
Q
Q
R
R
A
V
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
E
K
-----------
V
A
-----------
Q
Q
-
K
G
A
-----
I
P
G
V
Q
I
A
S
K
T
G
T
A
E
H
---
G
T
D
P
-
R
------
H
T
P
P
H
------
A
W
Y
I
A
F
A
P
A
Q
A
P
K
V
A
V
A
V
L
V
E
-
N
G
A
D
R
L
S
A
T
G
G
A
L
A
A
P
I
G
R
A
V
I
E
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
94.52
99%
-79
- C1 -
3UPO
1
PBPA_MYCTU
B:
[20-459]
------------------------------------------------
S
R
Q
R
G
Q
I
-
T
A
-
G
G
Q
L
L
A
Y
S
V
A
T
D
G
R
F
R
F
L
R
V
Y
P
N
P
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-
Y
S
S
T
A
L
E
R
A
E
--
D
P
I
L
N
G
--------
S
D
R
R
L
F
G
R
R
L
A
D
F
F
T
G
R
D
P
R
---
G
G
N
V
D
T
T
I
N
P
R
I
Q
Q
A
G
W
D
A
M
Q
Q
G
C
--
Y
--
G
P
C
K
G
A
V
V
A
L
E
P
S
T
G
K
I
L
A
L
V
S
S
P
S
Y
D
P
N
L
L
A
S
H
N
P
E
V
Q
A
Q
A
W
Q
R
L
G
D
N
P
A
S
P
L
T
N
R
A
I
S
E
T
Y
P
P
G
S
T
F
K
V
I
T
T
A
A
A
L
A
A
G
A
T
E
T
E
Q
L
-
T
A
A
P
-
T
I
P
L
P
G
S
T
A
Q
L
E
N
Y
G
G
A
P
C
G
-
D
E
P
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
L
G
I
R
T
G
A
D
A
L
R
S
M
A
R
A
F
G
L
D
S
---------------
P
P
R
--
P
T
P
L
Q
V
A
-
E
S
T
V
G
--
P
--
I
--
P
D
-----
S
A
A
L
G
M
T
S
I
G
Q
K
-------------
D
V
A
L
T
P
L
A
N
A
E
I
A
A
T
I
A
N
G
G
I
T
M
R
P
Y
L
V
G
S
L
K
G
P
D
L
A
N
I
S
T
T
V
R
Y
Q
Q
R
R
A
V
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
E
K
-----------
V
A
-----------
Q
-----------
P
G
V
Q
I
A
S
K
T
G
T
A
E
H
---
G
T
D
P
-
R
------
H
T
P
P
H
------
A
W
Y
I
A
F
A
P
A
Q
A
P
K
V
A
V
A
V
L
V
E
-
N
G
A
D
R
L
S
A
T
G
G
A
L
A
A
P
I
G
R
A
V
I
E
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------
24
HHSearch
94.04
97%
-74
- C1 -
3UN7
-
PBPA_MYCTU
A:
[48-488]
-----------------------------------------------
Y
S
R
Q
R
G
Q
I
-
T
A
-
G
G
Q
L
L
A
Y
S
V
A
T
D
G
R
F
R
F
L
R
V
Y
P
N
P
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-
Y
S
S
T
A
L
E
R
A
E
--
D
P
I
L
N
G
--------
S
D
R
R
L
F
G
R
R
L
A
D
F
F
T
G
R
D
P
R
---
G
G
N
V
D
T
T
I
N
P
R
I
Q
Q
A
G
W
D
A
M
Q
Q
G
C
--
Y
--
G
P
C
K
G
A
V
V
A
L
E
P
S
T
G
K
I
L
A
L
V
S
S
P
S
Y
D
P
N
L
L
A
S
H
N
P
E
V
Q
A
Q
A
W
Q
R
L
G
D
N
P
A
S
P
L
T
N
R
A
I
S
E
T
Y
P
P
G
S
T
F
K
V
I
T
T
A
A
A
L
A
A
G
A
T
E
T
E
Q
L
-
T
A
A
P
-
T
I
P
L
P
G
S
T
A
Q
L
E
N
Y
G
G
A
P
C
G
-
D
E
P
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
L
G
I
R
T
G
A
D
A
L
R
S
M
A
R
A
F
G
L
D
S
---------------
P
P
R
P
T
P
L
Q
V
A
E
S
T
V
G
P
I
P
---------
D
-----
S
A
A
L
G
M
T
S
I
G
Q
K
-------------
D
V
A
L
T
P
L
A
N
A
E
I
A
A
T
I
A
N
G
G
I
T
M
R
P
Y
L
V
G
S
L
K
G
P
D
L
A
N
I
S
T
T
V
R
Y
Q
Q
R
R
A
V
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
E
K
-----------
V
-------------
Q
-
K
G
A
-----
I
P
G
V
Q
I
A
S
K
T
G
T
A
E
H
---
G
T
D
P
-
R
------
H
T
P
P
H
------
A
W
Y
I
A
F
A
P
A
Q
A
P
K
V
A
V
A
V
L
V
E
-
N
G
A
D
R
L
S
A
T
G
G
A
L
A
A
P
I
G
R
A
V
I
E
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.45
25%
-76
- C1 -
5DF9
4
?
A:
[136-536]
---------------------------------------------------------------------------
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
R
G
R
E
G
I
E
L
A
F
--
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
--
G
R
V
I
K
D
V
Q
V
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
--
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
--------------
N
R
R
N
L
Q
P
A
A
-
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
-
V
D
V
-----
Y
P
G
-
T
L
Q
I
G
R
Y
T
I
R
D
V
S
R
N
S
R
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
------------------
Q
--
D
T
G
L
G
F
P
-
G
E
R
V
G
--
N
--
L
--
P
N
HRKWP
K
A
E
T
A
T
L
A
Y
G
Y
--------------
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
V
Q
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
---
Q
Q
-----------
V
V
-----------
E
A
-
Q
G
G
VFRAQ
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
SV
G
T
K
G
Y
R
------
E
N
A
Y
R
------
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
-
E
-
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
---------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
62.45
25%
-76
- C1 -
5DF7
5
?
A:
[136-536]
---------------------------------------------------------------------------
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
R
G
R
E
G
I
E
L
A
F
--
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
--
G
R
V
I
K
D
V
Q
V
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
--
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
--------------
N
R
R
N
L
Q
P
A
A
-
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
-
V
D
V
-----
Y
P
G
-
T
L
Q
I
G
R
Y
T
I
R
D
V
S
R
N
S
R
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
------------------
Q
--
D
T
G
L
G
F
P
-
G
E
R
V
G
--
N
--
L
--
P
N
HRKWP
K
A
E
T
A
T
L
A
Y
G
Y
--------------
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
V
Q
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
---
Q
Q
-----------
V
V
-----------
E
A
-
Q
G
G
VFRAQ
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
SV
G
T
K
G
Y
R
------
E
N
A
Y
R
------
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
-
E
-
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
---------------------------------------------------------------------------------------------------------------------------
26
HHSearch
62.11
31%
-63
- C1 -
4MNR
3
?
A:
[23-452]
-----------------------------------------------
A
R
S
E
R
G
T
I
-
A
T
Y
D
G
V
V
L
A
R
S
V
K
-
E
E
D
G
T
Y
E
R
E
Y
P
A
G
D
L
A
S
H
V
V
G
Y
S
S
P
Q
-
F
G
N
S
G
I
E
K
A
Y
--
N
D
T
L
K
G
--------------------------
T
A
---
G
N
D
V
T
L
T
L
N
S
K
I
Q
Q
A
A
Q
D
A
L
A
G
---------
R
K
G
A
C
V
V
M
D
P
D
T
G
A
I
L
A
M
A
S
A
P
T
Y
N
A
A
D
F
A
A
V
I
E
Q
-------
A
N
A
N
P
D
D
S
T
L
V
D
R
A
A
G
S
L
Y
A
P
G
S
T
F
K
I
V
T
L
A
T
A
L
E
D
D
V
A
G
E
D
T
V
F
S
S
P
G
-
T
M
E
I
G
N
--
A
T
V
S
N
F
N
K
A
N
----
Y
G
S
L
T
L
A
Q
A
T
E
L
S
S
N
T
V
F
G
Q
L
G
V
E
M
G
A
D
K
L
V
A
G
A
E
S
F
G
F
N
K
---------------
E
I
D
--
F
-
P
L
Y
T
P
-
E
S
L
M
P
S
A
E
--
D
L
Q
K
S
-----
P
W
E
L
A
W
A
A
A
G
E
P
VGDTTRPGRESPA
G
P
Q
A
T
V
L
E
M
A
M
V
G
T
A
I
A
N
D
G
V
I
M
Q
P
Y
L
V
D
S
V
N
N
A
N
G
E
R
S
F
S
A
S
P
T
K
L
M
Q
A
V
S
K
T
T
A
G
R
V
R
D
V
L
L
G
V
V
Q
-----------
N
G
-----------
T
G
T
A
A
A
-----
I
P
G
I
D
V
A
G
K
T
G
T
A
E
K
---
E
N
------------
G
N
D
------
S
W
F
V
G
M
A
P
A
E
D
P
R
V
V
V
A
I
V
I
E
-
D
G
E
E
-----
G
--
V
G
T
A
K
A
Q
N
V
L
K
T
A
L
E
---------------------------------------------------------------------------------------------------------------------------
49
Fugue
61.49
18%
-62
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
-
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
P
---------------------------------------------------
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
-
E
N
E
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
--------
L
N
S
I
L
A
G
T
------
D
G
R
T
M
D
---
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
--
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
--------------
T
K
E
G
I
T
E
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
-
F
N
S
S
-
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
E
G
L
T
G
--
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
------------------
V
--
P
T
R
F
G
L
T
-
D
E
Y
A
G
--
Q
--
L
P
A
D
N
-----
I
V
N
I
A
Q
S
S
F
G
Q
--------------
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
DPVYGTMYNHS
T
G
-----------
K
P
-
T
V
T
-----
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
---
A
D
E
K
-
N
GGYLVG
L
T
D
Y
I
------
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
-
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
Q
Q
S
P
Y
P
MPSVKDIS
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
TGTKIKNSSAEEGKNLAPN
Q
Q
V
L
I
L
S
DKAEEVPDMYGWT
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
SGSTVQKQDVRANTAIKDIK
K
I
T
L
T
L
G
D-
12
PsiBlast_PDB
61.46
25%
-77
- C1 -
3OCN
1
?
A:
[136-536]
---------------------------------------------------------------------------
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
R
G
R
E
G
I
E
L
A
F
--
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
--
G
R
V
I
K
D
V
Q
V
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
--
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
--------------
N
R
R
N
L
Q
P
A
A
-
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
-
V
D
V
-----
Y
P
G
-
T
L
Q
I
G
R
Y
T
I
R
D
V
S
R
N
S
R
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
------------------
Q
--
D
T
G
L
G
F
P
-
G
E
R
V
G
--
N
--
L
--
P
N
HRKWP
K
A
E
T
A
T
L
A
Y
G
Y
--------------
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
V
Q
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
---
Q
Q
-----------
V
V
-----------
E
A
-
Q
G
G
VFRAQ
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V--------------
E
N
A
Y
R
------
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
-
E
-
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
---------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.45
25%
-74
- C1 -
4KQR
11
?
A:
[136-536]
---------------------------------------------------------------------------
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
R
G
R
E
G
I
E
L
A
F
--
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
--
G
R
V
I
K
D
V
Q
V
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
--
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
--------------
N
R
R
N
L
Q
P
A
A
-
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
-
V
D
V
-----
Y
P
G
-
T
L
Q
I
G
R
Y
T
I
R
D
V
S
R
N
S
R
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
------------------
Q
--
D
T
G
L
G
F
P
-
G
E
R
V
G
--
N
--
L
--
P
N
H
RKWP
K
A
E
T
A
T
L
A
Y
G
Y
--------------
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
V
Q
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
---
Q
Q
-----------
V
V
-----------
E
A
-
Q
G
G
VFRAQ
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
VSV
G
T
K
G
Y
R
------
E
N
A
Y
R
------
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
-
E
-
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
---------------------------------------------------------------------------------------------------------------------------
25
HHSearch
61.36
33%
-61
- C1 -
4R23
7
?
A:
[50-474]
---------------------------------------------
K
S
A
Y
V
Q
R
G
A
I
-
I
T
S
D
G
V
T
L
A
E
S
V
K
-
Q
D
D
G
T
Y
V
R
N
Y
P
H
D
G
M
A
S
H
T
V
G
Y
I
S
T
Q
-
Y
G
T
A
G
I
E
S
S
M
--
N
E
T
L
T
G
--------
H
------
R
S
A
L
Y
S
M
A
G
I
-
T
T
---
G
S
S
V
V
L
T
I
N
S
Q
M
Q
A
V
A
E
A
A
L
Q
G
---------
Y
S
G
S
I
V
V
M
D
P
S
T
G
A
V
L
A
K
A
S
S
P
S
Y
T
H
A
E
L
G
T
I
-----------------
S
Q
L
V
D
R
T
T
Q
A
L
Y
S
P
G
S
S
F
K
T
V
T
L
A
A
G
I
D
T
H
K
T
T
L
D
T
T
Y
S
A
P
G
-
T
M
E
I
G
G
--
G
T
I
H
N
Y
A
N
E
D
----
M
G
T
I
P
L
R
E
A
F
A
R
S
S
N
T
A
L
A
Q
L
G
V
A
L
G
A
D
N
L
V
S
Y
A
R
A
F
G
Y
G
T
---------------
A
L
G
--
Q
D
-
F
S
T
T
-
P
S
L
M
P
--
N
PA
E
--
M
T
-----
T
W
E
L
A
W
A
S
C
G
L
P
V
G
E
H
ASPA-----
G
P
Q
T
T
V
M
Q
N
A
V
I
A
A
A
I
A
N
G
G
V
V
M
N
P
Y
I
V
D
R
V
L
S
P
E
G
A
V
V
S
T
T
S
P
K
S
L
G
Q
A
V
S
A
D
T
A
A
Q
V
R
E
A
M
L
G
V
V
E
-----------
S
G
-----------
T
G
M
G
A
R
-----
V
P
G
V
K
I
A
G
K
T
G
T
A
D
V
---
E
N
-----------
G
N
F
N
------
S
F
F
I
G
F
A
P
Y
D
H
P
T
L
V
V
S
V
V
I
E
-
G
N
G
E
----
N
V
L
G
Y
G
A
Q
V
G
G
R
V
L
A
Q
C
L
N
---------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
61.36
25%
-73
- C1 -
5DF8
8
?
A:
[136-536]
---------------------------------------------------------------------------
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
R
G
R
E
G
I
E
L
A
F
--
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
--
G
R
V
I
K
D
V
Q
V
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
--
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
--------------
N
R
R
N
L
Q
P
A
A
-
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
-
V
D
V
-----
Y
P
G
-
T
L
Q
I
G
R
Y
T
I
R
D
V
S
R
N
S
R
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
------------------
Q
--
D
T
G
L
G
F
P
-
G
E
R
V
G
--
N
--
L
--
P
N
H
RKWP
K
A
E
T
A
T
L
A
Y
G
Y
--------------
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
V
Q
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
---
Q
Q
-----------
V
V
-----------
E
A
-
Q
G
G
VFRAQ
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
SV
G
T
K
G
Y
R
------
E
N
A
Y
R
------
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
-
E
-
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
---------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.20
32%
-60
- C1 -
4R3J
4
?
A:
[54-458]
-------------------------------------------------
V
Q
R
G
A
I
I
T
S
-
D
G
V
T
L
A
E
S
V
K
Q
D
-
D
-
T
Y
V
R
N
Y
P
H
D
G
M
A
S
H
T
V
G
Y
I
S
T
Q
-
Y
G
T
A
G
I
E
S
S
M
--
N
E
T
L
T
G
---------------------------
T
---
G
S
S
V
V
L
T
I
N
S
Q
M
Q
A
V
A
E
A
A
L
Q
G
---------
Y
S
G
S
I
V
V
M
D
P
S
T
G
A
V
L
A
K
A
S
S
P
S
Y
-----------
T
H
A
E
L
G
T
I
I
E
S
G
T
G
S
Q
L
V
D
R
T
T
Q
A
L
Y
S
P
G
S
S
F
K
T
V
T
L
A
A
G
I
D
T
H
K
T
T
L
D
T
T
-
Y
S
A
P
G
T
M
E
I
G
G
G
T
--
I
H
N
Y
A
N
E
----
D
M
G
T
I
P
L
R
E
A
F
A
R
S
S
N
T
A
L
A
Q
L
G
V
A
L
G
A
D
N
L
V
S
Y
A
R
A
F
G
Y
G
T
ALGQD
F
S
T
T
P
S
L
M
P
N
P
A
E
--
M
T
T
W
E
L
A
-
W
A
S
C
G
L
-
P
--
V
--
G
E
-----
H
A
S
-------
P
A
-------------
G
P
Q
T
T
V
M
Q
N
A
V
I
A
A
A
I
A
N
G
G
V
V
M
N
P
Y
I
V
D
R
V
L
S
P
E
G
A
V
V
S
T
T
S
P
K
S
L
G
Q
A
V
S
A
D
T
A
A
Q
V
R
E
A
M
L
G
V
V
E
-----------
S
G
-----------
T
G
-
M
G
A
R----
V
P
G
V
K
I
A
G
K
T
G
T
A
-------
D
---------
N
G
N
F
N
------
S
F
F
I
G
F
A
P
Y
D
H
P
T
L
V
V
S
V
V
I
E
G
N
G
E
N
V
L
------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.05
25%
-74
- C1 -
4KQO
3
?
A:
[136-536]
---------------------------------------------------------------------------
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
R
G
R
E
G
I
E
L
A
F
--
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
--
G
R
V
I
K
D
V
Q
V
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
--
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
--------------
N
R
R
N
L
Q
P
A
A
-
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
-
V
D
V
-----
Y
P
G
-
T
L
Q
I
G
R
Y
T
I
R
D
V
S
R
N
S
R
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
------------------
Q
--
D
T
G
L
G
F
P
-
G
E
R
V
G
--
N
--
L
--
P
N
HRKWP
K
A
E
T
A
T
L
A
Y
G
Y
--------------
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
V
Q
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
---
Q
Q
-----------
V
V
-----------
E
A
-
Q
G
G
VFRAQ
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
SV
G
T
K
G
Y
R
------
E
N
A
Y
R
------
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
-
E
-
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
---------------------------------------------------------------------------------------------------------------------------
48
Fugue
60.86
19%
-56
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
-------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
---------
S
P
N
R
S
-
Y
P
-
N
G
Q
F
A
S
S
F
I
G
------
L
A
Q
L
H
E
N
E
D
G
S
K
S
L
L
G
T
S
G
--------
M
E
S
S
L
--
N
S
I
L
A
G
--------
T
D
G
----------------
R
TM
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
--
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
--------------
T
K
E
G
I
T
E
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
-
F
N
S
S
-
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
E
G
L
T
G
--
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
------------------
V
--
P
T
R
F
G
L
T
-
D
E
Y
A
G
--
Q
--
L
P
A
D
N
-----
I
V
N
I
A
Q
S
S
F
G
Q
--------------
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
-----------
D
P
VYGTMYNHSTG
K
P
-
T
V
T
-----
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
---
A
D
E
K
-
N
------
G
G
Y
L
V
GLTD
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
-
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
-LQ
Q
S
P
Y
P
MPSVKDIS
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
TGTKIKNSSAEEGKNLAPN
Q
Q
V
L
I
L
S
DKAEEVPDMYGWT
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
SGSTVQKQDVRANTAIKDIK
K
I
T
L
T
L
G
D
14
PsiBlast_PDB
60.80
25%
-74
- C1 -
4KQQ
5
?
A:
[136-536]
---------------------------------------------------------------------------
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
R
G
R
E
G
I
E
L
A
F
--
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
--
G
R
V
I
K
D
V
Q
V
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
--
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
--------------
N
R
R
N
L
Q
P
A
A
-
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
-
V
D
V
-----
Y
P
G
-
T
L
Q
I
G
R
Y
T
I
R
D
V
S
R
N
S
R
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
------------------
Q
--
D
T
G
L
G
F
P
-
G
E
R
V
G
--
N
--
L
--
P
N
HRKWP
K
A
E
T
A
T
L
A
Y
G
Y
--------------
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
V
Q
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
---
Q
Q
-----------
V
V
-----------
E
A
-
Q
G
G
VFRAQ
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
VSV
G
T
K
G
Y
R
------
E
N
A
Y
R
------
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
-
E
-
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
---------------------------------------------------------------------------------------------------------------------------