@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0021c: (2016-04-18 )
MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGGYGDRDWLARQFDLAAGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLAATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAVAARDYSIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV
Atome Classification :
(20 SA)
.........10........20........30........40...----------------..-.-..50----------------------....---.---..-..60---.---.---......70--......---.-------------------------------------..80........90........-100........110.......120.......130.......140.--------.--------....-------.-150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......------260-..--.---.----.---.-.---.--270-..---------......280.......290.......300.......310.......320---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
L
S
T
A
F
S
Q
M
FGIDYPIVSA
P
M
D
L
IAGG
E
L
A
A
AVSGAGGL
G
L
IG----------------GG-Y-G
D
R
-----------------------
D
W
L
A
---
R
---
Q
F-DLAA---G---A---PV
G
C
G
F
I
---
T
W
S
LAR---Q-------------------------------------P
Q
L
L
D
L
A
L
QYE
P
V
A
V
M
L
SFG
D
P
-
A
V
-
F
A
D
A
I
K
SAG
T
R
L
V
C
Q
IQN
R
T
Q
A
E
R
A
L
Q
VGA
D
V
L
V
AQGTEAGG--------H--------GHGP-------R-
S
T
L
T
L
V
P
E
I
V
D
L
V
TARGTD
I
P
V
I
A
AGGIADG
R
G
L
A
A
A
L
M
L
G
A
A
G
V
L
VG
T
R
F
Y
A
T
V
E
A
LSTPQARD
P
L
LAATG
D
D
M
C
R
T
T
I
Y
D
Q
L
RRYPWPQG
H
T
M
S
V
L
S
N
A
L
TDQFEDTE------
L
D
--
I
L
--
H
---
R
----
E
---
E
-
A
---
M
--
A
R
--
Y
W
---------
R
A
V
A
ARD
Y
S
I
A
NVTA
G
Q
A
A
G
L
V
N
A
V
L
P
A
A
D
V
I
T
G
M
A
Q
Q
A
A
R
T
L
T
A
MRAV---
106
HHSearch
93.27
32%
-111
- C6 -
3BO9
13
?
A:
[13-321]
M
T
V
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
----------------
S
G
-
A
-
M
K
P
-----------------------
D
D
L
R
---
K
---
A
I
-
S
E
L
R
Q
K
T
D
---
K
---
P
F
G
V
N
I
I
---
L
V
S
P
W
A
---
D
--------------------------------------
D
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
-
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
--------
H
--------
I
G
E
V
---------
T
T
F
V
L
V
N
K
V
S
R
S
V
-
N
----
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
---------
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
------
F
E
--
N
P
M
-
Q
A
--
E
----
E
---
M
-
L
---
V
--
G
S
--
L
R
---------
R
A
V
V
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
R
-----
104
HHSearch
90.94
34%
-112
* C6 *
2Z6I
5
?
A:
[1-314]
--
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
----------------
G
G
-
N
-
A
P
K
-----------------------
E
V
V
K
---
A
---
N
I
-
D
K
I
K
---
S
L
TD
K
---
P
F
G
V
N
I
M
---
L
L
S
P
F
V
---
E
--------------------------------------
D
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
-
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
--------
H
--------
I
G
K
L
---------
T
T
M
T
L
V
R
Q
V
A
T
A
I
-
S
----
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
---------
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
------
K
D
--
A
F
K
Q----
D
L
E
I
F
E
---
Q
M
G
---
A
--
G
A
--
L
A
---------
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
-----
1
PsiBlast_PDB
90.32
33%
-109
- C6 -
2Z6J
5
?
A:
[1-310]
--
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
----------------
G
G
-
N
-
A
P
K
-----------------------
E
V
V
K
---
A
---
N
I
-
D
K
I
K
---
S
L
TD
K
---
P
F
G
V
N
I
M
---
L
L
S
P
F
V
---
E
--------------------------------------
D
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
-
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
--------
H
---------
I
G
K
-------
L
-
T
T
M
T
L
V
R
Q
V
-----
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
---
T
T
I
S
A
Q
---------
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
------
K
D
--
A
F
------------------------------EQMGAG
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
---------
21
PsiBlast_CBE
89.86
33%
-108
- C6 -
2Z6J
4
?
B:
[1-310]
--
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
----------------
G
G
-
N
-
A
P
K
-----------------------
E
V
V
K
---
A
---
N
I
-
D
K
I
K
---
S
L
TD
K
---
P
F
G
V
N
I
M
---
L
L
S
P
F
V
---
E
--------------------------------------
D
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
-
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
--------
H
---------
I
G
K
-------
L
-
T
T
M
T
L
V
R
Q
V
-----
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
---
T
T
I
S
A
Q
----------
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
------
K
D
--
A
F
------------------------------EQMGAG
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
---------
2
PsiBlast_PDB
89.42
33%
-106
- C6 -
2Z6I
5
?
A:
[2-310]
---
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
----------------
G
G
-
N
-
A
P
K
-----------------------
E
V
V
K
---
A
---
N
I
-
D
K
I
K
---
S
L
TD
K
---
P
F
G
V
N
I
M
---
L
L
S
P
F
V
---
E
--------------------------------------
D
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
-
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
--------
H
---------
I
G
K
-------
L
-
T
T
M
T
L
V
R
Q
V
-----
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
---
T
T
I
S
A
Q
H
F
------
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
------
K
D
--
A
F
--
K
---
Q
--------------
D
--
L
E
--
I
F
E
Q
M
G
AG
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
---------
3
PsiBlast_PDB
88.86
29%
-104
- C6 -
3BO9
13
?
A:
[15-321]
--
V
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
----------------
S
G
-
A
-
M
K
P
-----------------------
D
D
L
R
---
K
A
I
S
E
L
-
R
Q
K
T
---
D
---
K
---
P
F
G
V
N
I
I
LVS
P
W
A
--------------------------------------------
D
D
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
-
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
--------
H
---------
I
G
E
-------
V
-
T
T
F
V
L
V
N
K
V
-----
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
----
I
R
D
T
V
V
T
G
A
K
-----
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
------
F
E
N
P
M
Q
--
A
---
E
----
E
---
M
-
L
---
V
--
G
S
--
L
R
---------
R
A
V
V
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
R
-----
105
HHSearch
88.01
30%
-115
- C6 -
4IQL
7
?
A:
[21-331]
---
M
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
----------------
A
G
-
S
-
M
H
P
-----------------------
D
N
L
E
---
H
---
H
I
-
R
S
C
K
A
A
T
D
---
K
---
P
F
G
V
N
V
P
---
L
L
Y
P
E
M
---
D
--------------------------------------
K
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
-
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
--------
H
--------
N
G
R
E
-------
E
T
T
T
L
C
L
I
P
E
V
V
D
A
V
-
N
----
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
L
K
A
----------
V
S
P
T
R
L
L
K
N
K
F
Y
Q
D
V
F
A
A
E
------
Q
R
--
G
A
--
S
---
V
----
E
---
E
-
L
R
E
L
L
--
G
R
G
R
A
K
---------
Q
G
I
F
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
A
G
M
P
T
----
107
HHSearch
81.80
25%
-117
- C6 -
2GJL
1
2NPD_PSEAE
A:
[3-319]
-
V
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
----------------
A
L
-
T
Q
P
S
P
-----------------------
E
A
L
A
---
A
---
E
I
-
A
R
C
R
---
E
L
T
D
R
---
P
F
G
V
N
L
T
---
L
L
P
T
Q
K
PVP
Y
-------------------------------------
A
E
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
-
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
--------
H
--------
P
G
E
D
-------
D
I
P
G
L
V
L
L
P
A
A
A
N
R
L
-
R
----
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
---------
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
------
A
R
G-
G
A
--
G
---
Y
----
A
DIA
A
-
L
---
V
S
G
Q
R
--
G
R
---------
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
-------
22
PsiBlast_CBE
81.69
39%
-141
- C4 -
4IQL
5
?
B:
[24-221]
------
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
----------------
A
G
-
S
-
M
H
P
-----------------------
D
N
L
E
HHI
R
---
S
C
-
K
A
A
T
---
D
---
K
---
P
F
G
V
N
-
V
---
P
L
L
Y
P
E
---
M
-------------------------------------
D
K
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
-
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
--------
H
N-------
G
R
E
E
-------
T
-
T
T
L
C
L
I
P
E
V
V
D
A
V
-----
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.57
39%
-140
- C4 -
4IQL
5
?
A:
[24-221]
------
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
----------------
A
G
-
S
-
M
H
P
-----------------------
D
N
L
E
H
H
I
R
---
S
C
-
K
A
A
T
---
D
---
K
---
P
F
G
V
N
-
V
---
P
L
L
Y
P
E
---
M
-------------------------------------
D
K
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
-
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
--------
H
N-------
G
R
E
E
-------
T
-
T
T
L
C
L
I
P
E
V
V
D
A
V
-----
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Fugue
80.84
25%
-111
- C6 -
2GJL
1
2NPD_PSEAE
A:
[3-326]
-
V
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
----------------
A
L
T
Q
-
P
S
P
-----------------------
E
A
L
A
---
A
---
E
I
-
A
R
C
R
---
E
---
L
T
D
R
P
F
G
V
N
L
T
L
L
P
T
Q
K
P
V
P
---
Y
-------------------------------------
A
E
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
-
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
--------
H
P-------
G
E
D
D
-------
I
-
P
G
L
V
L
L
P
A
A
A
N
R
L
-----
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
---------
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
R
GGAG
Y
A
--
D
I
--
A
---
A
----
L
---
V
-
S
---
G
--
Q
R
--
G
R
---------
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
108
HHSearch
80.13
31%
-110
- C6 -
4QIT
2
?
A:
[7-356]
--
M
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
----------------
I
T
-
G
-
S
A
A
-----------------------
E
K
G
R
---
A
---
L
I
-
R
E
V
R
---
G
L
TD
K
---
P
F
N
V
N
L
F
---
C
H
R
P
G
Q
---
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLSFLED
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
-
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
--------
S
--------
R
G
V
F
EPERGDA
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
-
S
----
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
---------
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
------
V
P
--
P
L
--
P
DY
P
F
----
V
Y
--
D
-
A
---
T
--
K
A
--
L
Q
T
--------
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
R
------------
26
PsiBlast_CBE
76.68
33%
-124
- C4 -
4QIU
2
?
B:
[10-263]
------
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
ITGSAAEKGRALIREV
R
G
-
L
-
T
D
K
PFNVNLFCHRPGQADPARERAWL
D
Y
L
K
---
P
---
L
F
A
E
F
G
A
---
E
---
P
---
P
V
R
L
K
N
I
---
Y
L
S
F
L
E
---
D
-------------------------------------
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
-
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
CRGVFEPE
R
--------
G
D
A
A
-------
I
-
G
T
L
A
L
V
----
R
L
L
A
A
R
G
S
-
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.51
33%
-116
* C4 *
4Q4K
1
?
A:
[1-268]
--
M
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
ITGSA
A
E
K
G
R
A
L
I
R
E
V
R
G
-
L
-
T
D
K
P
F
N
V
N
L
F
CHRP
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
---
P
---
L
F
A
E
F
G
A
---
E
---
P
---
P
V
R
L
K
N
I
---
Y
L
S
F
L
E
---
D
-------------------------------------
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
-
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
--------
H
RGVFEPER
G
D
A
A
-------
I
-
G
T
L
A
L
V
----
R
L
L
A
A
R
G
S
-
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
---
K
G
P
R
A
A
R
T
A
L
-------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.44
32%
-119
- C4 -
4QIT
2
?
A:
[7-274]
--
M
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
ITGSA
A
E
K
G
R
A
L
I
R
E
V
R
G
-
L
-
T
D
K
P
F
N
V
N
L
F
CHRP
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
---
P
---
L
F
A
E
F
G
A
---
E
---
P
---
P
V
R
L
K
N
I
---
Y
L
S
F
L
E
---
D
-------------------------------------
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
-
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
SRGVFEPE
R
--------
G
D
A
A
-------
I
-
G
T
L
A
L
V
----
R
L
L
A
A
R
G
S
-
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
---
K
G
P
R
A
A
R
T
A
L
-------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.24
33%
-114
- C4 -
4Q4K
1
?
B:
[2-268]
---
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
ITGSA
A
E
K
G
R
A
L
I
R
E
V
R
G
-
L
-
T
D
K
P
F
N
V
N
L
F
CHR
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
---
P
---
L
F
A
E
F
G
A
---
E
---
P
---
P
V
R
L
K
N
I
---
Y
L
S
F
L
E
---
D
-------------------------------------
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
-
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
--------
H
RGVFEPER
G
D
A
A
-------
I
-
G
T
L
A
L
V
----
R
L
L
A
A
R
G
S
-
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
---
K
G
P
R
A
A
R
T
A
L
-------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.03
33%
-124
- C4 -
4QIU
2
?
A:
[10-263]
------
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
ITGSA
A
E
K
G
R
A
L
I
R
E
V
R
G
-
L
-
T
D
K
P
F
N
V
N
L
F
CHRP
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
---
P
---
L
F
A
E
F
G
A
---
E
---
P
---
P
V
R
L
K
N
I
---
Y
L
S
F
L
E
---
D
-------------------------------------
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
-
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
CRGVFEPE
R
--------
G
D
A
A
-------
I
-
G
T
L
A
L
V
----
R
L
L
A
A
R
G
S
-
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.65
33%
-119
- C4 -
4QIS
1
?
B:
[10-273]
------
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
GSA
A
E
K
G
R
A
L
I
R
E
V
R
G
-
L
-
T
D
K
P
F
N
V
N
L
F
CHRP
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
---
P
---
L
F
A
E
F
G
A
---
E
---
P
---
P
V
R
L
K
N
I
---
Y
L
S
F
L
E
---
D
-------------------------------------
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
-
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
--------
H
RGVFEPER
G
D
A
A
-------
I
-
G
T
L
A
L
V
----
R
L
L
A
A
R
G
S
-
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
---
K
G
P
R
A
A
R
T
A
L
-------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
75.16
32%
-117
- C4 -
4QIT
2
?
B:
[8-274]
---
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
ITGSA
A
E
K
G
R
A
L
I
R
E
V
R
G
-
L
-
T
D
K
P
F
N
V
N
L
F
CHRP
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
---
P
---
L
F
A
E
F
G
A
---
E
---
P
---
P
V
R
L
K
N
I
---
Y
L
S
F
L
E
---
D
-------------------------------------
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
-
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
SRGVFEPE
R
--------
G
D
A
A
-------
I
-
G
T
L
A
L
V
----
R
L
L
A
A
R
G
S
-
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
---
K
G
P
R
A
A
R
T
A
L
-------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.95
33%
-121
- C4 -
4QIS
1
?
A:
[10-273]
------
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
ITGSA
A
E
K
G
R
A
L
I
R
E
V
R
G
-
L
-
T
D
K
P
F
N
V
N
L
F
CHRP
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
---
P
---
L
F
A
E
F
G
A
---
E
---
P
---
P
V
R
L
K
N
I
---
Y
L
S
F
L
E
---
D
-------------------------------------
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
-
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
--------
H
RGVFEPER
G
D
A
A
-------
I
-
G
T
L
A
L
V
----
R
L
L
A
A
R
G
S
-
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
---
K
G
P
R
A
A
R
T
A
L
-------------------------------------------------------------------------------------------------------------------------------------