@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0032: (2016-04-18 )
MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLATTDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTLPDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYPRFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGCSGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESGDMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQAEYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380-----.......390.......400.......---410--....------...420........430.......440.......450.......460.......470.......480.......490.....--.--.500.......510.......520.......530...-....540.-.---.---..-.-...550........560.......570.......580.......590.......600.......610.......-620........630.......640.......650.......660-....-.--.--..670.......680.......--690.......700.......710....-..-.720.......730.......740.......750.....--..760.......770
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPTGLG
Y
D
F
LRPVEDSGI
N
D
L
K
H
Y
Y
F
M
A
DLADGQPLGR
A
N
L
Y
S
V
C
F
D
LATTDRKLT
P
A
W
R
T
T
I
K
R
W
F
P
G
F
M
T
F
R
F
L
E
C
G
L
L
T
MVSNPLALRSDT
D
L
E
R
V
L
P
V
L
A
G
Q
M
D
Q
L
AHDDGS
D
F
L
M
I
R
DV
D
P
E
H
Y
Q
R
Y
L
D
I
L
RPLGFRPALGFSRVD
T
T
I
S
W
S
S
V
E
E
A
L
G
C
L
S
H
KRRLPLK
T
S
L
E
F
R
E
R
FGI
E
V
E
E
L
D
E
Y
A
E
H
A
P
V
L
A
R
L
W
R
N
VK
T
E
A
K
DYQREDL
N
P
E
F
F
A
A
C
S
R
HLHGRS
R
L
W
L
F
R
YQGT
P
I
A
F
F
L
N
VWGADE
N
Y
I
L
L
EWGIDR
D
F
E
H
Y
R
K
A
N
L
Y
R
A
A
L
M
L
S
L
K
D
A
I
S
R
D
K
R
R
M
E
MG
I
T
N
Y
F
T
KLRIPG
A
R
V
I
P
T
I
Y
F
L
RHSTDP
V
H
T
A
T
L
A
R
M
M
M
H
NIQRPTLP
D
D
M
S
E
E
F
C
R
W
E
E
R
IRLDQDGL
P
E
H
D
I
F
R
K
I
D
-----
R
QHKYT
G
L
K
LGG
V
Y
GFYPRFTGPQRST---
V
K
A--AEL
G
------
E
I
V
L
-
L
GTN
S
Y
LGLAT
H
P
E
V
V
E
A
S
A
E
A
T
R
RYGTGCSGSPLLN
G
T
L
D
L
H
V
S
L
E
Q
E
L
A
C
F
LGK
P
A
A
V
L
CSTGYQ
S
N
L
A
A
I
S
A
L
C
--E--SGD
M
I
I
Q
D
A
LNH
R
S
L
F
D
A
A
RLSGA
D
F
T
L
Y
RHN
D
M
D
H
L
-
A
R
V
L
R
--R-T---E---GR-
R
-
R
I
I
V
-
V
D
A
VFSMEG
T
V
A
D
L
A
T
I
A
E
L
A
D
RHG
C
R
V
Y
VDESHALGVLGPDGR
G
A
S
A
A
L
G
V
L
A
R
M
D
V
V
M
G
T
F
S
K
S
F
A
S-V-GGFIAGD
R
P
V
V
D
Y
I
RHNGSG
H
V
F
SASLPP
A
A
A
A
A
T
H
A
A
LRV--SRRE-
P
--
D
--
R
R
A
R
V
L
A
A
A
E
Y
M
A
T
G
L
A
RQGYQ--AEYH
G
T
A
I
V
P
V
I
LGNPT
V
A
H
A
G
Y
L
R
L
M
-RS-G
V
Y
VNPVAPPAVPEERSGFR
T
S
Y
L
A
D
H
R
Q
S
D
L
D
R
A
L
H
V
F
--
A
G
L
A
E
DLTPQGAAL
50
HHSearch
97.77
37%
-97
* C1 *
3A2B
2
?
A:
[17-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
A
K
G
L
Y
A
Y
F
R
P
I
Q
S
K
Q
D
T
E
----
V
K
--
I
D
G
R
------
R
V
L
M
-
F
G
S
N
S
Y
L
G
L
T
T
D
T
R
I
I
K
A
A
Q
D
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
--
G
--
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
-
R
A
K
L
S
--
R
-
L
P--
E
---
D
S
-
A
-
K
L
I
C
-
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
G
A
G
T
A
S
H
F
G
L
N
D
D
V
D
L
I
M
G
T
F
S
K
S
L
A
S
-
L
-
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
--
I
Q
N
E
-
P
--
E
--
H
I
E
K
L
W
K
N
T
D
Y
A
K
A
Q
L
L
D
H
G
F
D
--
L
G
A
T
E
S
P
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
-
D
D
-
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
--
V
K
V
F
K
Q
A
-------
1
PsiBlast_PDB
96.59
38%
-90
- C1 -
3A2B
2
?
A:
[7-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
S
-----
Q
F
K
I
V
E
E
L
K
A
K
G
L
Y
A
Y
F
R
P
I
Q
S
K
Q
D
T
E
---
V
K
I
---
D
G
R
------
R
V
L
M
-
F
G
S
N
S
Y
L
G
L
T
T
D
T
R
I
I
K
A
A
Q
D
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
--
G
--
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
--
L
-
P
---
E
---
D
S
-
A
-
K
L
I
C
-
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
G
A
G
T
A
S
H
F
G
L
N
D
D
V
D
L
I
M
G
T
F
S
K
S
L
A
S
-
L
-
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
--
I
Q
N
E
-
P
--
E
--
H
I
E
K
L
W
K
N
T
D
Y
A
K
A
Q
L
L
D
H
G
F
D
--
L
G
A
T
E
S
P
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
-
D
D
-
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
------------------
12
PsiBlast_PDB
92.95
30%
-92
- C1 -
3TQX
2
?
A:
[5-396]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
I
L
S
Q
L
N
-----
K
E
--
I
E
G
L
K
K
A
G
L
Y
K
S
E
R
I
I
T
S
P
Q
N
A
E
---
I
K
V
--
G
E
-
K
------
E
V
L
N
-
F
C
A
N
N
Y
L
G
L
A
D
H
P
A
L
I
K
T
A
Q
T
V
V
E
Q
Y
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
T
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
--
G
--
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
-
E
A
K
L
K
--
E
-
A
---
D
E
K
G
A
R
-
F
-
K
L
I
A
-
T
D
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
E
N
G
R
G
T
P
E
Y
C
G
V
A
D
R
V
D
I
L
T
G
T
L
G
K
A
L
G
G
-
A
S
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
T
S
L
K
V
L
E
L
--
L
K
T
E
G
P
--
Q
--
L
R
K
Q
L
Q
E
N
S
R
Y
F
R
A
G
M
E
K
L
G
F
Q
--
L
V
P
G
N
H
P
I
I
P
V
M
L
G
D
A
Q
L
A
T
N
M
A
D
H
L
L
-
Q
E
-
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
--
G
Q
V
G
K
K
L
-------
52
HHSearch
92.33
33%
-94
- C1 -
1FC4
2
KBL_ECOLI
A:
[17-398]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
R
A
E
G
L
F
K
E
E
R
I
I
T
S
A
Q
Q
A
D
---
I
T
V
--
A
D
G
S
------
H
V
I
N
-
F
C
A
N
N
Y
L
G
L
A
N
H
P
D
L
I
A
A
A
K
A
G
M
D
S
H
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
M
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
--
G
--
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
-
E
A
R
L
K
--
E
-
A
R
E
A
G
---
A
R
-
H
-
V
L
I
A
-
T
D
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
E
N
G
R
G
S
H
E
Y
C
D
V
M
G
R
V
D
I
I
T
G
T
L
G
K
A
L
G
G
A
S
-
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
A
S
I
K
V
L
E
M
--
V
E
A
G
-
S
--
E
--
L
R
D
R
L
W
A
N
A
R
Q
F
R
E
Q
M
S
A
A
G
F
T
--
L
A
G
A
D
H
A
I
I
P
V
M
L
G
D
A
V
V
A
Q
K
F
A
R
E
L
Q
-
K
E
-
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
--
T
R
I
G
K
Q
L
G
------
10
PsiBlast_PDB
91.99
36%
-96
- C1 -
2X8U
-
?
A:
[46-400]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
Q
A
L
D
E
F
G
S
G
T
T
G
S
R
V
L
N
G
T
Y
Q
G
H
K
A
C
E
D
A
L
K
E
F
Y
G
T
E
H
A
I
V
F
S
T
G
Y
Q
A
N
L
G
M
I
S
T
L
A
--
G
--
K
G
D
Y
I
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
W
L
G
D
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
A
E
-
A
G
K
L
V
V
-
L
E
G
V
Y
S
M
M
G
D
I
A
P
L
Q
E
M
V
A
V
S
K
K
H
G
A
M
I
L
V
D
E
A
H
G
M
G
F
F
G
E
H
G
R
G
V
F
E
E
A
G
V
E
A
D
V
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
-
G
G
F
C
V
S
N
H
P
K
F
E
V
L
R
L
V
C
R
P
Y
V
F
T
A
S
L
P
P
S
V
V
A
T
A
A
T
S
I
R
K
--
L
M
H
A
-
G
--
D
--
K
R
A
H
L
W
K
N
S
R
R
L
H
Q
G
L
R
D
M
G
Y
K
L
G
T
E
T
A
Q
S
A
I
I
A
V
I
L
T
D
M
A
Q
A
V
A
L
W
Q
G
L
L
-
E
A
-
G
L
Y
V
N
T
A
R
P
P
A
T
P
A
G
M
F
L
L
R
C
S
L
C
A
E
H
S
D
E
Q
V
E
Q
I
L
G
M
F
E
S
A
G
R
A
T
G
V
I
P
-----
49
HHSearch
91.80
32%
-94
- C1 -
3TQX
2
?
A:
[18-397]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
A
G
L
Y
K
S
E
R
I
I
T
S
P
Q
N
A
E
---
I
-
K
--
V
G
E
K
------
E
V
L
N
-
F
C
A
N
N
Y
L
G
L
A
D
H
P
A
L
I
K
T
A
Q
T
V
V
E
Q
Y
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
T
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
--
G
--
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
-
E
A
K
L
K
--
E
-
A
D
E
K
G
---
A
R
-
F
-
K
L
I
A
-
T
D
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
E
N
G
R
G
T
P
E
Y
C
G
V
A
D
R
V
D
I
L
T
G
T
L
G
K
A
L
G
G
A
S
-
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
T
S
L
K
V
L
E
L
--
L
K
T
E
-
G
P
-
Q
--
L
R
K
Q
L
Q
E
N
S
R
Y
F
R
A
G
M
E
K
L
G
F
Q
--
L
V
P
G
N
H
P
I
I
P
V
M
L
G
D
A
Q
L
A
T
N
M
A
D
H
L
L
-
Q
E
-
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
--
G
Q
V
G
K
K
L
G
------
13
PsiBlast_PDB
91.64
33%
-95
- C1 -
1FC4
2
KBL_ECOLI
A:
[31-397]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
S
A
Q
Q
A
D
---
I
T
V
--
A
D
G
S
------
H
V
I
N
-
F
C
A
N
N
Y
L
G
L
A
N
H
P
D
L
I
A
A
A
K
A
G
M
D
S
H
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
M
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
--
G
--
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
-
E
A
R
L
K
E
A
R
-
E
---
A
---
G
A
-
R
-
H
V
L
I
A
T
D
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
E
N
G
R
G
S
H
E
Y
C
D
V
M
G
R
V
D
I
I
T
G
T
L
G
K
A
L
G
G
-
A
S
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
A
S
I
K
V
L
E
M
--
V
E
A
G
-
S
--
E
--
L
R
D
R
L
W
A
N
A
R
Q
F
R
E
Q
M
S
A
A
G
F
T
--
L
A
G
A
D
H
A
I
I
P
V
M
L
G
D
A
V
V
A
Q
K
F
A
R
E
L
Q
-
K
E
-
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
--
T
R
I
G
K
Q
L
-------
8
PsiBlast_PDB
90.01
34%
-94
- C1 -
2W8W
1
?
A:
[22-408]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
S
K
F
D
G
L
I
A
E
R
Q
K
----
L
L
D
S
G
V
T
D
P
F
A
I
V
M
E
Q
V
K
S
P
---
T
E
A
--
V
I
R
G
K-----
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
Y
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
K
E
P
A
-
K
L
V
V
-
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
-
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
--
L
M
T
A
-
H
--
E
--
K
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
R
LG
T
E
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
----------------
5
PsiBlast_PDB
89.80
34%
-93
- C1 -
2XBN
1
?
A:
[21-408]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
L
S
K
F
D
G
L
I
A
E
R
Q
K
----
L
L
D
S
G
V
T
D
P
F
A
I
V
M
E
Q
V
K
S
P
---
T
E
A
--
V
I
R
G
K
-----
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
K
E
P
A
-
K
L
V
V
-
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
-
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
--
L
M
T
A
-
H
--
E
--
K
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
R
LG
T
E
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
----------------
6
PsiBlast_PDB
89.40
34%
-93
- C1 -
2W8T
-
?
A:
[23-409]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
S
K
F
D
G
L
I
A
E
R
Q
K
----
L
L
D
S
G
V
T
D
P
F
A
I
V
M
E
Q
V
K
S
P
---
T
E
A
--
V
I
R
G
K
-----
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
C
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
K
E
P
A
-
K
L
V
V
-
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
-
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
--
L
M
T
A
-
H
--
E
--
K
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
R
L
G
T
E
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
----------------
11
PsiBlast_PDB
89.39
34%
-91
- C1 -
4BMK
6
?
A:
[43-430]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
L
S
K
F
D
G
L
I
A
E
R
Q
K
----
L
L
D
S
G
V
T
D
P
F
A
I
V
M
E
Q
V
K
S
P
---
T
E
A
--
V
I
R
G
K-----
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
K
E
P
A
-
K
L
V
V
-
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
A
S
V
G
T
-
V
-
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
--
L
M
T
A
-
H
--
E
--
K
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
R
L
G
T
E
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
----------------
4
PsiBlast_PDB
89.30
34%
-93
- C1 -
2W8J
1
?
A:
[21-408]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
L
S
K
F
D
G
L
I
A
E
R
Q
K
----
L
L
D
S
G
V
T
D
P
F
A
I
V
M
E
Q
V
K
S
P
---
T
E
A
--
V
I
R
G
K
-----
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
K
E
P
A
-
K
L
V
V
-
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
-
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
--
L
M
T
A
-
H
--
E
--
K
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
R
LG
T
E
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
----------------
9
PsiBlast_PDB
89.16
34%
-96
- C1 -
2W8U
-
?
A:
[23-409]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
S
K
F
D
G
L
I
A
E
R
Q
K
----
L
L
D
S
G
V
T
D
P
F
A
I
V
M
E
Q
V
K
S
P
---
T
E
A
--
V
I
R
G
K-----
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
Y
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
K
E
P
A
-
K
L
V
V
-
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
-
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
--
L
M
T
A
-
H
--
E
--
K
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
R
LG
T
E
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
----------------
7
PsiBlast_PDB
89.11
34%
-96
- C1 -
2W8V
-
?
A:
[22-409]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
L
S
K
F
D
G
L
I
A
E
R
Q
K
----
L
L
D
S
G
V
T
D
P
F
A
I
V
M
E
Q
V
K
S
P
---
T
E
A
--
V
I
R
G
K-----
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
W
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
K
E
P
A
-
K
L
V
V
-
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
-
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
--
L
M
T
A
-
H
--
E
--
K
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
R
LG
T
E
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
----------------
2
PsiBlast_PDB
89.04
34%
-94
- C1 -
2JG2
-
?
A:
[22-409]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
L
S
K
F
D
G
L
I
A
E
R
Q
K
----
L
L
D
S
G
V
T
D
P
F
A
I
V
M
E
Q
V
K
S
P
---
T
E
A
--
V
I
R
G
K-----
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
K
E
P
A
-
K
L
V
V
-
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
K
S
V
G
T
-
V
-
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
--
L
M
T
A
-
H
--
E
--
K
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
R
LG
T
E
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
----------------
31
PsiBlast_CBE
88.91
31%
-86
- C1 -
1DJE
4
BIOF_ECOLI
A:
[3-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
E
K
I
N
A
A
L
D
A
R
G
A
A
D
A
L
R
R
----------------------
R
Y
P
V
A
Q
G
A
G
R
W
L
---
V
----
A
D
D
R
------
Q
Y
L
N
-
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
-
A
R
L
L
A
--
S
-
P
---
C
---
P
G
-
Q
-
Q
M
V
V
-
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
K
P
E
L
L
V
V
--
T
F
G
K
G
F
G
V
-
S
-
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
--
I
R
S
D
-
E
--
G
D
A
R
R
E
K
L
A
A
L
I
T
R
F
R
A
G
V
Q
D
L
P
F
T
--
L
A
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
--
H
G
------------
20
PsiBlast_PDB
88.76
31%
-81
- C1 -
1DJ9
4
BIOF_ECOLI
A:
[3-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
E
K
I
N
A
A
L
D
A
R
G
A
A
D
A
L
R
R
----------------------
R
Y
P
V
A
Q
G
A
G
R
W
L
---
V
----
A
D
D
R
------
Q
Y
L
N
-
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
-
A
R
L
L
A
--
S
-
P
---
C
---
P
G
-
Q
-
Q
M
V
V
-
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
K
P
E
L
L
V
V
--
T
F
G
K
G
F
G
V
-
S
-
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
--
I
R
S
D
-
E
--
G
D
A
R
R
E
K
L
A
A
L
I
T
R
F
R
A
G
V
Q
D
L
P
F
T
--
L
A
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
--
H
G
------------
21
PsiBlast_CBE
88.62
34%
-95
- C1 -
4BMK
4
?
B:
[43-430]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
L
S
K
F
D
GLIAE
R
Q
K
----
L
L
D
S
G
V
T
D
P
F
A
I
V
M
E
Q
V
K
S
P
---
T
E
A
--
V
I
R
G
K-----
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
-
D
K
R
L
G
--
R
-
L
---
P
---
K
E
P
A
-
K
L
V
V
-
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
V
V
G
T
F
S
A
S
V
G
T
-
V
-
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
--
L
M
T
A
-
H
--
E
--
K
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
R
LG
T
E
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
----------
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
----------------
46
HHSearch
88.33
30%
-92
- C1 -
2BWN
4
HEM1_RHOCB
A:
[13-397]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
K
A
Q
W
N
RP
D
G
G
K
------
Q
D
I
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
--
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
-
R
E
L
I
A
--
A
-
D
D--
P
---
A
A
-
P
-
K
L
I
A
-
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
G
V
-
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
--
L
K
T
A
-
E
G
Q
K
--
L
R
D
A
Q
Q
M
H
A
K
V
L
K
M
R
L
K
A
L
G
M
P
--
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
-
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
--
D
L
L
W
----------
66
Fugue
88.32
30%
-90
- C1 -
2BWN
4
HEM1_RHOCB
A:
[2-397]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
N
L
A
-----
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
---
P
K
A
--
Q
W
N
R
PDG
G
K
Q
D
I
T
V
-
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
--
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
-
R
E
L
I
A
--
A
D
D
---
P
---
A
A
-
P
-
K
L
I
A
-
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
G
V
-
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
K
T
A
E
G
-
Q
--
K
--
L
R
D
A
Q
Q
M
H
A
K
V
L
K
M
R
L
K
A
L
G
M
P
--
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
-
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
--
D
L
L
W
----------
18
PsiBlast_PDB
87.67
33%
-85
- C1 -
2G6W
1
BIOF_ECOLI
A:
[24-382]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
V
A
Q
G
A
G
R
W
L
---
V
----
A
D
D
R
------
Q
Y
L
N
-
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
-
A
R
L
L
A
--
S
-
P
---
C
---
P
G
-
Q
-
Q
M
V
V
-
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
K
P
E
L
L
V
V
--
T
F
G
K
G
F
G
V
-
S
-
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
--
I
R
S
D
-
E
--
G
D
A
R
R
E
K
L
A
A
L
I
T
R
F
R
A
G
V
Q
D
L
P
F
T
--
L
A
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
--
H
G
------------