@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0037c: (2016-04-18 )
MPRVEVGLVIHSRMHARAPVDVWRSVRSLPDFWRLLQVRVASQFGDGLFQAGLAGALLFNPDRAADPMAIAGAFAVLFLPYSLLGPFAGALMDRWDRRWVLVGANTGRLALIAGVGTILAVGAGDVPLLVGALVANGLARFVASGLSAALPHVVPREQVVTMNSVAIASGAVSAFLGANFMLLPRWLLGSGDEGASAIVFLVAIPVSIALLWSLRFGPRVLGPDDTERAIHGSAVYAVVTGWLHGARTVVQLPTVAAGLSGLAAHRMVVGINSLLILLLVRHVTARAVGGLGTALLFFAATGLGAFLANVLTPTAIRRWGRYATANGALAAAATIQVAAAGLLVPVMVVCGFLLGVAGQVVKLCADSAMQMDVDDALRGHVFAVQDALFWVSYILSITVAAALIPEHGHAPVFVLFGSAIYLAGLVVHTIVGRRGQPVIGR
Atome Classification :
(20 SA)
-----------------------------------.........10.......----.20.......-----.30..-----......40........50.-------......-.---60..------......70........---80....-....90..-.-.-....-----------100--------------........---.110....-----------------.---------..120-----.--.---......---.130.---.....----.----------------140.-----......150--.....--.-.---.160------------......---.170......---.180--...-----------.....-----190-------........---.200------...-......210-------.-.-.--....-------220...---...--.230-------.--------.--.--.-----------------.-------------------------------------------------..240--.-----------------.-------------------------------------------------.-......250.----.---...----..260------......-----.270.......280.-------....--..290-------.----..----------.---.-.-----------...300.......310----.-------..-------..--------...320.-------------------------..------...--..----330--------......---.-------340.-----------..------..------...-.350.......---------360.....----------------------...370.------....-------.-----.380...-...-.390..---..----..------...400..---..--.-..410....-------...420...------....430.----------......440-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------MPR
V
E
V
G
L
V
I
HSRMHARA----
P
V
D
V
W
R
S
V
R
S
-----
L
P
D
F
W
-----
R
L
L
Q
V
R
V
A
S
Q
FG
D
G
L
F
Q
AG-------LA
G
A
L
L
-F---NPDR------AAD
P
M
A
I
A
G
A
F
A
V
L
F
L
---
P
Y
S
L
L
G
-
P
F
A
G
A
L
M
D
-R-W-DR
R
W
-----------
V
----------------
L
V
GANTG
R
---
L
A
L
I
AGV
G
-----------------
T
---------
I
L
A
-------V--G---AG
D
V
P
L
---
L
V
G
A
L
---
V
A
N
G
L
----
A
----------------
R
F
V
A
-----
S
G
L
S
A
A
LP---HVVPR--E-
Q
---
V
V
T
M------------N
S
V
A
I
A
---
S
G
A
V
S
A
F
LGA---N
F
M
---
L
L
P
-----------
R
W
LLG-----S---------GDEG
A
S
A
I
---
V
F
--------
L
V
A
-
I
P
V
S
I
A
L
L
W
-------S-L-R--FGPR-------VLGPDD---TER--AIHG-------
S
--------
A
--
V
--
Y
-----------------
A
-------------------------------------------------
V
V
T
----
G
-----------------
W
-------------------------------------------------
L
-HGA
R
T
V
V
QL
P
----
T
---
V
A
A
----
G
L
S
G
L
------
A
A
H
R
M
V
-----
V
G
I
N
S
L
L
I
L
L
L
V
R
H
V
-------
T
A
R
A
--VG
G
---------
L
----
G
T
----------
A
---
L
-
L
-----------
F
F
A
A
T
G
L
G
A
F
L
A
N
VL-----
T
-------
P
T
-------
A
I
--------
R
R
WGR-Y-------------------------AT------ANG--A
L
----
A
A
A
--------
A
T
I
Q
V
A
---
A
-------
A
--
G
-----------
L
L
------
V
P
------
V
M
V
-
V
C
G
F
L
L
G
V
A
G
Q
---------
V
-
V
K
L
C
A
D
----------------------
S
A
MQM
D
V
------
D
D
A
L-------R-----G
H
V
F
A
V
Q
-
D
A
L
-
F
W
--
V
S
---
Y
I
----
L
S
------
I
T
V
A
A
A
LI---PE--H-GHA
P
V
F
V
L
F-------G
S
A
I
Y
L
A
G
L
------
V
V
H
T
I
VGR----------RGQPVIGR------------------------
12
Fugue
84.04
15%
-112
- C6 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
---------------------------------------------
Y
N
S
S
Y
I
F
S
----
I
T
L
V
A
T
L
G
G
L
-----
L
F
G
Y
D
-----
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
------------------
N
L
S
E
------
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
---
G
C
I
I
G
G
-
A
L
G
G
Y
C
S
N
-
R
-
F
-
G
R
R
D
-----------
S
----------------
L
K
I
A
A
V
L
F
---
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPV
Y
---------
L
A
G
-------
Y
--
V
---
P
E
F
V
I
Y
---
R
I
I
G
G
---
I
G
V
G
L
----
A
----------------
S
M
L
S
-----
P
M
Y
I
A
E
L
A
---
P
A
H
I
R
--
G
-
K
---
L
V
S
F
------------
N
Q
F
A
I
I
---
F
G
Q
L
L
V
Y
C
V
N
---
Y
F
I
---
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
-----
S
---------
E
C
I
P
A
L
L
F
---
L
M
--------
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
R
GK
Q
E
Q
A
-
E
-
G
--
I
L
R
K
-------
I
M
G
N
T
L
---
A
T
Q
--
A
V
Q
E
-------
I
--------
K
--
H
--
S
-----------------
L
-------------------------------------------------
D
H
G
----
R
-----------------
K
-------------------------------------------------
T
-
G
G
R
L
L
M
F
G
V
G
----
V
---
I
V
I
----
G
V
M
-
L
------
S
I
F
Q
Q
F
-----
V
G
I
N
--
V
V
L
Y
Y
A
P
E
V
-------
F
K
T
L
--
G
A
S
---------
T
----
D
I
----------
A
---
L
-
L
-----------
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
-----
A
-------
I
M
-------
T
V
--------
D
K
F
G
R
-
K
-------------------------
P
L
------
Q
I
I
--
G
A
----
L
G
M
--------
A
I
G
M
F
S
---
L
-------
G
--
T
-----------
A
F
Y
T
QAP
G
I
V
------
A
L
L
-
S
M
L
F
Y
V
A
A
F
A
M
---------
S
-
W
G
P
V
C
W
----------------------
V
L
L
S
E
I
F
------
P
N
A
I
-------
R
-----
G
K
A
L
A
I
A
-
V
A
A
-
Q
W
--
L
A
---
N
Y
----
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
---
A
H
--
F
-
H
N
G
F
S
Y
W
I
Y
-------
G
C
M
G
V
L
A
A
L
------
F
M
W
K
F
V
P
E
T---------
K
G
K
T
L
E
E
L
EALWE-------------------
13
Fugue
80.68
18%
-127
- C1 -
3U1K
2
PNPT1_HUMAN
A:
[4-627]
---M
A
S
A
V
A
V
D
LGN
R
K
L
E
I
S
S
GKLARFAD
G
S
A
V
V
Q
S
G
D
T
A
V
M
V
T
A
V
S
K
T
K
P
S
P
SQFM
P
L
V
V
D
Y
R
Q
K
A
AAAGR
I
P
T
N
Y
LTS
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
YF
Y
D
T
Q
V
L
C
N
L
L
A
-
V
---
D
G
V
N
------
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S--
D
I
P
W
N
G
-
P
V
G
A
V
R
I
G
-
I
-
I
-
D
G
E
Y
-----------
V
V
NPT
R
K
E
M
S
S
ST
L
N
L
V
V
A
G
A
P
K
S
Q
---
I
V
M
L
E
A
S
A
-----------------
E
NIL
Q
Q
D
F
C
H
A
I
K
-------
V
--
G
---
V
K
Y
T
Q
Q
---
I
I
Q
G
I
---
Q
Q
L
V
K
----
E
T
G
V
T
K
R
TPQKLFTPS
P
E
I
V
K
-----
Y
T
H
K
L
A
M
E
---
R
L
Y
A
V
--
F
-
T
---
D
Y
E
H
------------
D
K
V
S
R
D
---
E
A
V
N
K
I
R
L
D
T
---
E
E
Q
---
L
K
E
-----------
K
F
P
E
A
-----
D
---------
P
Y
E
I
I
E
S
F
---
N
V
--------
V
A
K
-
E
V
F
R
S
I
V
L
N
-------
E
Y
K
-
R
--
C
D
G
R
DL
T
S
L
R
N
V
S
C
E
V
D
---
M
F
K
--
T
L
H
G
-------
S
--------
A
--
L
--
F
-----------------
Q
-------------------------------------------------
R
------
G
-----------------
Q
-------------------------------------------------
T
-
Q
-
V
L
C
T
V
T
F
D
----
S
---
L
E
S
----
G
I
K
S
D
------
Q
V
I
T
A
I
-----
N
G
I
K
D
K
N
F
M
L
H
Y
E
-
F
-------
P
P
Y
A
--
T
N
E
---------
I
----
G
K
----------
V
---
T
G
L
-----------
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
-----
Y
-------
P
V
IPRDFP
F
T
I
--------
R
V
T
S
E
-
V
-------------------------
L
E
------
S
N
G
S
S
S
M
----
A
S
A
--------
C
G
G
S
L
A
---
L
-------
M
--
D
-----------
S
G
------
V
P
------
I
S
S
A
V
A
G
V
A
I
G
L
V
T
K
T
D
PEKGEIE
D
-
Y
R
L
L
T
D
IL
G
I
E
D
Y
N
GDMD
F
K
I
A
G
T
NK
G
I
T
A
L
Q
A
D
I
KLPGIP
I
K
I
V
-------
M
-----
E
A
I
Q
Q
A
S
-
V
A
K
-
K
E
--
I
L
---
Q
I
----
M
N
------
K
T
I
S
K
P
R
A
---
S
R
--
K
-
E
N
G
P
V
V
E
T
V
Q
V
P
LSK
R
A
K
F
V
G
P
G
G
Y
------
N
L
K
K
L
Q
A
E
----------
T
G
V
T
I
S
Q
V
DEE
T
F
S
V
F
A
PT
P
S
A
M
H
E
A
R
D
F
I
T
E
20
HHSearch
76.70
14%
-108
- C6 -
5AYN
10
?
A:
[7-408]
------------------------------------------------------------------------
L
R
I
E
T
-----
Q
L
L
L
G
R
L
L
T
R
S
G
D
Q
A
W
D
F
V
-------
V
P
F
A
L
L
-------
V
I
F
-----
P
G
K
L
Q
V
A
A
F
Y
Y
L
I
V
K
I
---
G
T
F
L
L
T
-
P
S
S
G
K
W
I
D
-
T
-
H
-
P
R
I
Q
-----------
V
----------------
V
K
W
G
V
W
L
Q
---
F
F
A
I
L
A
G
M
-----------------
V
---------
F
F
G
M
L
D
G
L
V
R
A
--
G
G--
R
E
S
W
L
L
S
V
L
F
I
A
L
A
---
L
S
G
V
M
----
A
----------------
S
L
G
S
Q
I
T
D
I
S
V
G
N
D
L
A
P
---
S
L
V
A
P
--
E
-
K
---
L
T
H
F
------------
N
S
W
L
R
R
---
I
D
L
A
T
E
V
G
A
P
---
I
L
A
---
G
A
L
-----------
F
--------------------------
P
L
A
G
L
F
--------
L
I
G
-
L
W
N
L
V
S
F
V
P
-------
E
-
Y
F
L
--
L
R
N
V
-------
I
Q
R
S
G
L
---
K
I
K
--
V
--
L
-------
T
--------
E
--
A
---------------------------------------------------------------------------------------------------------------------------------------------------
I
N
L
R
G
S
F
S
D
P
----
I
---
F
W
L
----
I
L
S
Y
A
------
L
L
W
L
S
V
-----
L
S
P
H
G
V
L
L
A
A
Y
L
K
D
E
-------
M
R
-----
L
P
---------
E
----
T
E
----------
I
---
G
-
L
-----------
F
R
G
L
G
A
V
F
G
L
I
S
T
V
S
-----
F
-------
P
Y
-------
L
V
--------
R
R
L
G
L
-
I
-------------------------
S
S
------
S
R
W
--
H
L
G
F
Q
G
V
T
L
--------
G
I
A
V
T
A
F
A
M
G
-------
S
--
T
-----------
A
S
------
V
Y
------
V
F
L
-
G
C
I
L
L
S
R
V
G
L
Y
---------
G
-
F
S
N
G
E
F
----------------------
E
L
R
Q
R
L
I
------
P
E
G
R
-------
R
-----
G
E
L
N
S
L
S
-
S
L
T
-
T
T
--
S
A
---
T
L
----
I
L
------
F
S
A
G
S
L
L
P
---
Q
T
--
E
-
D
F
K
Y
L
V
Y
V
-------------------------------------------------------------------------
14
Fugue
75.17
14%
-110
- C4 -
4DZI
6
?
A:
[4-394]
--------------------------------------
A
L
N
Y
R
V
I
D
V
D
N
H
Y
Y
E
----
P
L
D
S
F
T
--
R
H
-----
L
D
K
K
F
-----
K
R
R
G
V
Q
M
L
S
D
G
K
R
T
W
A
V
I
G
--------
D
R
V
N
H
-
F
---
I
P
N
P
------
T
F
D
P
I
I
V
P
G
C
L
D
L
L
F
R
---
G
E
I
P
D
G
-
V
D
P
A
S
L
M
K
-
V
-
E
-
R
L
A
D
-----------
H
------------------------------------------------------------------------
P
--
E
---
Y
Q
N
R
D
A
---
R
I
A
V
M
---
D
E
Q
D
I
----
E
----------------
T
A
F
M
-----
L
------
P
---
T
F
G
C
G
--
V
-
E
---
E
A
L
K
------------
H
D
I
E
A
T
---
M
A
S
V
H
A
F
------
N
L
W
---
L
D
E
-----------
D
W
G
F
D
-----
R
---------
P
D
H
-------------------
R
I
-
I
A
A
P
I
V
S
L
A
-------
D
--------------------
P
T
R
---
A
V
E
--
E
V
D
F
-------
V
--------
L
--
A
---------------------------------------------------------------------------------------------------------------------------------------------------
R
G
A
K
L
V
L
V
R
P
----
A
---
P
V
P
----
G
L
V
K
P
R
S
LGDR
S
H
D
P
V
W
-----
A
R
L
A
E
A
G
V
P
V
G
F
H
L
S
-------
D
S
------
G
---------
Y
----
L
H
----------
I
---
A
-
A
-----------
A
W
G
G
K
A
K
D
P
L
D
Q
V
L
L
-----
D
-------
D
R
-------
A
I
--------
H
D
T
M
A
-
S
-------------------------
M
I
------
V
H
G
--
V
F
----
T
R
H
--------
P
K
L
K
A
V
---
S
-------
I
--
E
-----------
N
G
------
S
Y
----------
F
V
H
R
L
I
K
R
L
K
K
---------
A
-
A
N
T
-
Q
P
----------------------
Q
Y
F
P
E
D
P
------
V
E
Q
L
-------
R
-----
N
N
V
W
I
A
P
-
Y
Y
E
-
D
D
--
L
P
---
E
L
----
A
R
------
V
I
G
V
D
K
I
L
---
F
G
--
S
-
D
W
P
H
G
E
G
L
A
-------
S
P
V
S
F
T
A
E
L
KGFS
E
S
D
I
R
K
I
M
R
D
----------
N
A
L
D
L
L
G
-------------------------
15
Fugue
75.16
15%
-131
* C4 *
1CB7
2
GLME_CLOCO
B:
[1-483]
-------------------MELKNKKWT
D
E
E
F
H
K
Q
R
E
E
V
L
Q
Q
W
P
T
G
K
E
V
D
L
Q
E
----
A
V
D
Y
L
K
K
I
P
A
-----
E
K
N
F
A
-----
E
K
L
V
L
A
K
K
K
--
G
I
T
M
A
Q
P
R
-------
A
G
V
A
L
L
-
D
---
E
H
I
E
------
L
L
R
Y
L
Q
D
E
G
G
A
D
F
L
P
S
T
I
D
A
Y
T
R
Q
N
-
R
Y
D
E
C
E
N
G
-
I
-
K
-
E
S
E
K
A
GRSLLNGFPG
V
----------------
N
F
G
V
K
G
C
R
----
K
V
L
E
A
V
N
-----------------
L
---------
P
L
Q
-------
A
R
H
G
---
T
P
D
S
R
L
---
L
A
E
I
I
---
H
A
G
G
W
----
T
----------------
S
N
E
G
-----
G
G
I
S
-------
Y
N
V
P
Y
--
A
-
K
---
N
V
T
I
------------
E
K
S
L
L
D
---
W
Q
Y
C
D
R
L
V
G
F
---
Y
E
E
---
Q
G
V
-----------
H
I
N
R
E
-----
P
---------
F
G
P
L
T
G
T
L
---
V
P
---------
P
S
-
M
S
N
A
V
G
I
T
E
-------
A
-
L
-
L
--
A
A
E
------------------------
Q
G
-------------------
V
--
K
-----------------
N
-------------------------------------------------
I
T
V
----
G
-----------------
Y
-------------------------------------------------
G
-
E
C
G
N
M
I
Q
D
I
A
----
A
---
L
R
C
----
L
E
E
Q
T
------
N
E
Y
L
K
A
-----
Y
G
Y
N
D
V
F
V
T
T
V
F
H
Q
W
MGGFPQD
E
S
K
A
--
F
G
V
---------
I
----
V
T
----------
A
---
T
-
T
-----------
I
A
A
L
A
G
A
T
K
V
I
V
K
T
P
HEAIG
I
-------
P
T
-------
K
E
--------
A
N
A
A
G
-
I
-------------------------
K
A
------
T
K
M
--
A
L
----
N
M
L
EG
Q
R
M
P
M
S
K
E
L
E
T
E
---
M
-------
A
--
V
-----------
I
K
------
A
E
------
T
K
C
-
I
L
D
K
M
F
E
L
G
K
G
---------
D
-
L
A
I
G
T
V
----------------------
K
A
F
E
T
G
V
------
M
D
I
P
FGPSKYN
A
-----
G
K
M
M
P
V
R
-
D
N
L
-
G
C
--
V
R
---
Y
L
EFGN
V
P
------
F
T
E
E
I
K
N
Y
---
N
R
--
E
-
R
L
Q
E
R
A
K
F
E
-------
G
R
D
V
S
-
F
Q
M
------
V
I
D
D
I
F
A
V
----------
G
K
G
R
L
I
G
R
PE----------------------
19
Fugue
72.41
18%
-117
- C2 -
3OGZ
1
?
A:
[3-610]
NPS
N
S
N
L
Q
A
L
R
E
E
L
C
TPGLDQGHLFEGWPETVDEC
N
E
R
Q
I
A
L
L
T
D
L
Y
M
F
S
N
M
Y
----
P
G
G
V
A
Q
Y
I
R
N
-----
G
H
E
L
L
-----
A
R
E
S
E
E
V
D
F
A
A
L
E
M
P
P
L
I
F
-------
E
A
P
S
L
H
-
R
---
R
T
A
E
------
R
T
A
L
E
N
A
G
T
A
M
L
C
K
T
V
---
F
V
L
V
A
G
-
G
L
G
E
R
L
G
Y
-
S
-
S
-
I
K
V
S
-----------
L
----------------
P
V
E
T
A
T
N
T
---
T
Y
L
A
Y
Y
L
R
-----------------
W
---------
A
Q
R
-------
V
--
G
---
G
K
E
V
P
F
---
V
I
M
T
S
DDT
H
D
R
T
L
----
Q
----------------
L
L
R
E
-----
L
Q
L
E
V
P
N
L
---
H
V
L
K
Q
--
G
-
Q
---
V
F
C
F
ADSAAH
L
A
L
D
ET
G
K
L
L
R
K
P
HG
H
G
D
V
H
S
L
I
Y
N
---
A
T
V
AQP
L
V
N
-----------
D
W
L
A
------------------
A
G
Y
E
S
I
---
V
F
I
Q
DTNAG
A
T
I
T
-
I
P
I
S
L
A
L
S
A
-------
E
-
H
-
S
--
L
D
M
N
-------
F
T
C
I
P
R
---
V
P
K
--
E
P
I
G
-------
L
--------
L
--
C
--
R
-----------------
T
-------------------------------------------------
K
K
N
----
S
-----------------
G
-------------------------------------------------
D
-
P
W
L
V
A
N
V
E
Y
N
----
V
---
F
A
E
----
V
S
R
A
L
------
G
F
S
P
F
P
-----
G
S
V
N
T
L
V
F
K
L
S
S
Y
V
D
-------
R
L
R
E
--
S
H
G
---------
I
----
V
P
----------
E
---
F
-
I
N
P
K
Y
SDETRRS
F
K
K
P
A
R
I
E
S
L
M
Q
D
I
A
-----
L
LFSEDD
Y
R
V
-------
G
G
--------
T
V
F
E
R
-
F
SYQPVKNS
L
E
E
A
A
G
L
V
A
Q
GNGAYC
A
A
T
------
G
E
A
--
A
F
----
Y
E
L
--------
Q
R
R
R
L
K
---
A
-------
I
--
G
-----------
L
P
------
L
F
Y
S
SQPE
V
T
V
-
A
K
D
A
F
G
V
R
L
F
P
---------
I
-
I
V
L
D
T
V
----------------------
C
A
S
S
G
S
L
------
D
D
L
A
-------
R
V
F
P
TP
E
K
V
H
I
D
Q
-
H
S
T
-
L
I
--
V
E
G
RV
I
I
----
E
S
------
L
E
L
Y
G
A
L
T
I
R
G
P
T
--
D
-
S
M
A
L
P
H
V
V
R
-------
N
A
V
V
R
N
A
G
W
------
S
V
H
A
I
L
S
L
CSRLS
E
V
D
R
I
R
G
F
V
L
K
K
T
A
M
A
V
M
D
C-----------------
30
HHSearch
71.55
12%
-120
- C6 -
4LDS
-
?
A:
[13-408]
------------------------------------------------------------------------------------
A
L
G
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
-------
L
L
F
I
H
K
-------
D
I
------
P
L
N
S
T
T
E
G
I
V
V
S
S
M
L
I
---
G
A
I
V
G
A
-
G
S
S
G
P
L
A
D
-
K
-
L
-
G
R
R
R
-----------
L
----------------
V
M
L
I
A
I
V
F
---
I
I
G
A
L
I
L
A
-----------------
A
---------
S
----------------
T
N
L
A
L
L
---
I
I
G
R
L
---
I
I
G
L
A
----
V
----------------
G
G
S
M
-----
S
T
V
P
V
Y
L
S
---
E
M
A
P
T
--
E
-
Y
---
R
G
S
L
------------
G
S
L
N
Q
L
---
M
I
T
I
G
I
L
A
A
Y
---
L
V
N
---
Y
A
F
-----------
A
D
I
E
-------------------
G
W
R
W
M
---
L
G
--------
L
A
V
-
V
P
S
V
I
L
L
V
G
-------
I
-
Y
-
F
--
M
P
E
S
-------
P
R
W
L
L
E
---
N
R
N
E
E
A
A
R
Q
V
M
K
I
T
YD
D
--------
S
E
I
D
--
K
E
L
K
E
M
------------
K
-------------------------------------------------
E
I
N
----
A
-----------------
I
-------------------------------------------------
S
-
E
S
T
W
T
V
I
K
S
P
----
W
---
L
G
R
----
I
L
I
V
G
------
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
--------
A
G
-----
L
G
---------
E
----
A
A
----------
S
---
I
-
L
-----------
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
-----
A
-------
I
F
-------
V
V
--------
D
K
I
D
R
-
K
-------------------------
K
L
------
L
V
G
--
G
N
----
I
G
M
--------
I
A
S
L
L
I
M
--
A
I
L
I
W
T
IG
I
--
A
-----------
S
S
------
A
W
------
I
I
I
-
V
C
L
S
L
F
I
V
F
F
G
---------
I
S
W
G
P
V
L
W
----------------------
V
M
L
P
E
L
F
------
P
M
R
A
-------
R
-----
G
A
A
T
G
I
S
-
A
L
V
-
L
N
--
I
G
---
T
L
----
I
V
------
S
L
F
F
P
I
L
S
---
D
A
--
L
-
S
T
E
W
V
F
L
I
F
-------
A
----------------------------------------------------------------
18
Fugue
71.09
11%
-113
- C6 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
--------------------------------------------
F
K
P
A
P
H
K
A
R
----
L
P
A
A
E
I
D
P
T
Y
-----
R
R
L
R
W
-----
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
-------
F
A
L
A
M
P
-
Y
---
L
V
E
Q
------
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
---
A
Y
G
F
S
K
-
F
I
M
G
S
V
S
D
-
R
-
S
-
N
P
R
V
-----------
F
----------------
L
P
A
G
L
I
L
A
---
A
A
V
M
L
F
M
G
-----------------
F
---------
V
P
W
-------
A
--
T
---
S
S
I
A
V
M
---
F
V
L
L
F
---
L
C
G
W
F
----
Q
----------------
G
M
G
W
-----
P
P
C
G
R
T
M
V
---
H
W
W
S
Q
--
K
-
E
---
R
G
G
I
------------
V
S
V
W
N
C
---
A
H
N
V
G
G
G
I
P
P
---
L
L
F
---
L
L
G
-----------
M
A
W
F
N
-----
D
----------
W
H
A
A
L
Y
M
---
P
A
--------
F
C
A
-
I
L
V
A
L
F
A
F
A
-------
M
-
M
-
R
--
D
T
P
Q
-------
S
C
G
L
P
P
---
I
E
E
--
Y
K
N
D
-------
T
--------
A
--
K
--
Q
-----------------
I
-------------------------------------------------
F
M
Q
----
Y
-----------------
V
-------------------------------------------------
L
-
P
N
----
K
L
L
W
----
Y
---
I
A
I
----
A
N
V
F
V
------
Y
L
L
R
Y
G
-----
I
L
D
W
S
P
T
Y
L
K
E
V
K
H
F
-------
A
L
D
K
--
S
S
W
---------
A
----
Y
F
----------
L
---
Y
-
E
-----------
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
-----
K
-------
V
F
-------
R
G
--------
N
R
G
A
T
-
G
-------------------------
V
F
------
F
M
T
--
L
V
----
T
I
A
--------
T
I
V
Y
W
M
---
N
-------
P
--
A
-----------
G
N
------
P
T
------
V
D
M
-
I
C
M
I
V
I
G
F
L
I
Y
---------
G
-
P
V
M
L
I
G
----------------------
L
H
A
L
E
L
A
------
P
K
K
A
-------
A
-----
G
T
A
A
G
F
T
-
G
L
F
-
G
Y
--
L
G
---
G
S
----
V
A
------
A
S
A
I
V
G
Y
T
---
V
D
--
F
F
G
W
D
G
G
F
M
V
M
-------
I
G
G
S
I
L
A
V
I
------
L
L
I
V
V
M
I
G
----------
E
K
R
R
H
E
Q
L
LQELVP------------------
17
Fugue
70.82
19%
-91
- C3 -
2VIU
5
?
A:
[9-328]
-------------------------------------------
S
T
A
T
L
C
L
G
H
H
----
A
V
P
N
G
T
L
V
K
T
-----
I
T
D
-------
D
Q
I
E
V
T
N
A
T
E
----
L
V
Q
S
S
-------
S
T
G
K
I
C
-
N
---
N
P
H
R
------
I
L
D
-----
G
I
D
C
T
--
L
---
I
D
A
L
L
G
D
P
H
C
D
V
F
Q
N
E
T
-
W
-
D
--------------
L
----------------
F
V
E
R
S
K
A
F
----------
S
-----------------
N
---------
C
Y
P
-------
Y
--
D
---
V
P
D
Y
A
S
---
L
R
S
L
V
---
A
S
S
G
T
----
L
----------------
E
F
I
T
-----
E
G
F
T
--
W
T
---
G
V
I
Q
N
--
G
---------------------
G
S
N
A
C
K
---
R
G
P
G
S
G
F
F
S
R
-----------
L
-----------
N
W
L
T
K
-----
S
---------
G
S
---
T
Y
P
---
V
L
--------
N
V
T
-
M
P
N
N
D
N
F
D
K
-------
L
-
Y
-
I
--
W
G
I
H
-------
H
P
S
T
N
Q
---
E
Q
T
--
S
L
Y
V
-------
Q
--------
A
--
S
--
G
-----------------
R
-------------------------------------------------
V
T
V
----
S
-----------------
T
-------------------------------------------------
R
-
R
S
Q
Q
T
I
I
P
N
I
----
G
---
S
R
P
----
W
V
R
G
L
------
S
S
R
I
S
I
-----
Y
W
T
I
V
K
P
G
D
V
L
V
I
N
S
-------
N
G
N
L
--
I
A
P
---------
R
----
G
-----------------
Y
-----------
F
K
M
R
T
G
K
S
S
I
M
R
S
-------
D
-------
A
P
-------
I
D
--------
T
C
I
S
E
-
C
-------------------------
I
T
------
P
N
G
--
S
I
----
P
N
D
--------
K
P
F
Q
-------------------------------------------------------------------------------------------------------
N
V
------
N
K
-------------------------------------------------------------
I
T
--
Y
-
G
A
C
P
K
Y
V
K
Q
-------
N
T
--------------
L
K
L
A
T
G
M
----------
R
N
V
P
E
K
Q
T
------------------------
10
Fugue
70.55
11%
-113
- C6 -
1PV6
-
LACY_ECOLI
A:
[1-417]
-----------------------------------
M
Y
Y
L
K
------
N
T
N
F
W
M
F
----
G
L
F
F
F
F
Y
F
F
I
-----
M
G
A
Y
F
-----
P
F
F
P
I
W
L
H
D
I
N
H
------------------------------------
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
---
F
S
L
L
F
Q
-
P
L
F
G
L
L
S
D
-
K
-
L
-
G
L
R
K
-----------
Y
----------------
L
L
W
I
I
T
G
M
---
L
V
M
F
A
P
F
F
-----------------
I
---------
F
I
F
-------
G
--
P
---
L
L
Q
Y
N
I
---
L
V
G
S
I
---
V
G
G
I
Y
----
L
----------------
G
F
C
F
-----
N
A
G
A
P
A
V
E
---
A
F
I
E
K
--
V
-
S
---
R
R
S
N
------------
F
E
-------
F
G
R
A
R
M
F
G
C
V
---
G
W
A
---
L
G
A
-----------
S
I
V
G
I
-----
M
---------
F
T
I
N
N
Q
F
V
---
F
W
--------
L
G
S
-
G
C
A
L
I
L
A
V
L
-------
L
-
F
-
F
--
A
K
T
D
-------
A
P
S
S
A
T
---
V
A
N
--
A
V
G
A
-------
N
--------
H
--
S
------------------------------------------------------------------------
A
----
F
-----------------
S
-------------------------------------------------
L
-
K
L
A
L
E
L
F
R
Q
P
----
K
---
L
W
F
----
L
S
L
Y
V
------
I
G
V
S
C
T
-----
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-------
F
A
T
G
--
E
Q
G
---------
T
----
R
V
----------
F
---
G
-
Y
-----------
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
-----
A
-------
P
L
-------
I
I
--------
N
R
I
G
G
-
K
-------------------------
N
A
------
L
L
L
--
A
G
----
T
I
M
--------
S
V
R
I
I
G
---
S
-------
S
--
F
-----------
A
T
S-----
A
L
------
E
V
V
-
I
L
K
T
L
H
M
F
E
V
P
---------
F
-
L
L
V
G
C
F
----------------------
K
Y
I
T
S
Q
F
------
E
V
R
F
-------
S
-----
A
T
I
Y
L
V
C
-
F
C
F
F
K
Q
--
L
A
---
M
I
----
F
M
------
S
V
L
A
G
N
M
Y
---
E
S
--
I
-
G
F
Q
G
A
Y
L
V
L
-------
G
L
V
A
L
G
F
T
L
------
I
S
V
F
T
L
S
G
----------
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A-----------------
37
HHSearch
69.24
14%
-117
- C6 -
2CFQ
5
LACY_ECOLI
A:
[4-387]
-----------------------------------------------------------------
L
K
-----
N
T
N
F
W
-----
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
-------
F
P
I
W
L
H
-
D
-----
I
N
------
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
---
F
S
L
L
F
Q
-
P
L
F
G
L
L
S
D
-
K
-
L
-
G
L
R
K
-----------
Y
----------------
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
-----------------
F
---------
G
------------
P
---
L
L
Q
Y
N
I
---
L
V
G
S
I
---
V
G
G
I
Y
LGFC
F
----------------
N
A
G
A
-----
P
A
V
E
A
F
I
E
---
K
V
S
R
-----
R
---
S
N
F
E
------------
F
G
R
A
R
M
---
F
G
C
V
G
W
A
L
G
A
---
S
I
V
---
G
I
M
-----------
F
T
-
I
-------------------
N
N
Q
F
V
---
F
W
--------
L
G
S
-
G
C
A
L
I
L
A
V
L
-------
L
-
F
-
F
--
A
K
T
D
-------
A
P
S
S
A
T
---
V
A
N
-------------
A
--------
V
--
G
--
A
-----------------
N
-------------------------------------------------
H
S
A
----
F
-----------------
S
-------------------------------------------------
L
-
K
L
A
L
E
L
F
R
Q
P
----
K
---
L
W
F
----
L
S
L
Y
V
------
I
G
V
S
C
T
-----
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-------
F
A
T
G
--
E
Q
G
---------
T
----
R
V
----------
F
---
G
-
Y
-----------
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
-----
A
-------
P
L
-------
I
I
--------
N
R
I
G
G
-
K
-------------------------
N
A
------
L
L
L
--
A
G
----
T
I
M
--------
S
V
R
I
I
G
S
--
S
-------
F
--
A
-----------
T
S
------
A
L
------
E
V
V
-
I
L
K
T
L
H
M
F
E
V
P
---------
F
-
L
L
V
G
C
F
----------------------
K
Y
I
T
S
Q
F
------
E
V
R
F
-------
S
-----
A
T
I
Y
L
V
C
F
C
F
F
-
K
Q
--
L
A
---
M
I
----
F
M
------
S
V
L
A
G
N
M
Y
---
E
S
--
I
-
G
F
Q
G
A
Y
L
V
L
-------
G
L
---------------------------------------------------------------
33
HHSearch
69.13
11%
-115
- C6 -
4J05
1
?
A:
[51-507]
----------------------------------------------------------------------------------------------
L
F
I
I
N
Q
V
-------
A
P
M
L
A
Q
-
V
Y--
F
P
K
T
------
G
L
P
A
Q
R
Q
D
L
M
K
A
A
A
N
I
---
G
C
V
V
G
Q
-
V
M
F
G
V
L
G
D
-
S
-
F
-
G
R
K
F
-----------
V
----------------
Y
G
K
E
L
I
L
I
---
I
V
A
T
I
F
Q
M
-----------------
S
---------
A
P
S
-------
H
--
W
D
G
N
R
V
L
T
W
I
---
T
I
C
R
V
---
F
L
G
I
G
----
I
----------------
G
G
D
Y
-----
P
M
S
A
T
V
V
S
---
D
R
A
N
I
--
H
-
R
---
R
G
T
L
------------
L
C
F
I
F
A
---
N
Q
G
W
G
S
F
V
G
S
---
L
V
T
---
I
V
T
-----------
I
S
G
F
K
-----
H
RLKSGHTHD
V
D
K
A
W
R
I
L
---
I
G
--------
L
S
L
-
I
P
A
F
G
T
L
Y
Q
-------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-
Q
E
F
V
A
Y
F
S
T
W
NHF
R
N
---
L
L
G
----
S
M
L
G
W
------
F
L
V
D
I
A
-----
F
Y
G
I
N
L
N
Q
S
V
V
L
A
Q
--------
I
G
-----
F
A
---------
G
----
K
T
GD
V
Y
D
K
L
F
Q
L
A
---
T
-
G
-----------
N
I
I
V
T
A
L
G
F
L
P
G
Y
Y
F
-----
T
-------
L
F
-------
L
I
--------
D
I
V
G
R
-
K
-------------------------
K
L
------
Q
F
M
--
G
F
----
I
M
S
--------
G
L
F
L
A
I
L
--
A
-------
G
E
-
I
-----------
D
H
IG
K
---
G
P
------
L
L
A
-
C
F
T
F
M
Q
F
F
F
N
F
---------
G
-
A
N
T
T
T
F
----------------------
I
V
A
A
E
L
F
------
P
T
R
I
-------
R
-----
A
S
A
H
G
I
S
-
A
A
A
-
G
K
--
C
G
---
A
I
----
L
S
------
S
L
V
F
N
Q
L
K
---
A
K
--
I
-
G
T
S
A
V
L
W
I
F
-------
F
S
T
C
-
I
L
G
F
------
I
S
T
F
L
I
D
E
----------
T
M
G
V
----------------------------
32
HHSearch
68.79
13%
-115
- C6 -
3WDO
-
?
A:
[11-373]
------------------------------------------------------------------------
R
R
A
T
W
-----
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
-------
L
T
T
Y
G
M
-
A
-----
L
Q
------
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
---
T
Q
A
V
F
Q
-
I
P
F
G
L
L
S
D
-
R
-
I
-
G
R
K
P
-----------
L
----------------
I
V
G
G
L
A
V
F
---
A
A
G
S
V
I
A
A
-----------------
L
---------
S
----------------
D
S
I
W
G
I
---
I
L
G
R
A
---
L
Q
G
S
G
----
A
------------------
I
A
-----
A
A
V
M
A
L
L
S
---
D
L
T
R
E
--
Q
-
N
---
R
T
K
A
------------
M
A
F
I
G
V
---
S
F
G
I
T
F
A
I
A
M
---
V
L
G
---
P
I
I
-----------
T
H
K
L
-------------------
G
L
H
A
L
---
F
W
--------
M
I
A
-
I
L
A
T
T
G
I
A
L
-------
T
-
I
W
V
--
V
P
N
S
-------
S
T
H
V
L
N
---
R
------------------------
E
--
S
------------------------------------------------------------------------
G
----
M
-----------------
V
-------------------------------------------------
K
-
G
S
F
S
K
V
L
A
E
P
----
R
---
L
L
K
----
L
N
F
G
I
------
M
C
L
H
M
L
-----
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
--------
A
G
-----
F
P
---------
A
----
A
E
----------
H
W
K
V
Y
-
L
-----------
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
-----
Y
-------
A
E
-------
V
K
--------
R
K
M
K
Q
----------------------------
V
------
F
V
F
--
C
V
----
G
L
I
--------
V
V
A
E
I
V
L
W
-
N
-------
A
--
Q
-----------
T
Q
------
F
W
------
Q
L
V
-
V
G
V
Q
L
F
F
V
A
F
N
---------
L
-
M
E
A
L
L
P
----------------------
S
L
I
S
K
E
S
------
P
A
G
Y
-------
K
-----
G
T
A
M
G
V
Y
-
S
T
S
-
Q
F
--
L
G
---
V
A
----
I
G
------
G
S
L
G
G
W
I
D
---
G
M
--
F
-
D
G
Q
G
V
F
L
A
-------------------------------------------------------------------------
25
HHSearch
67.62
11%
-127
- C6 -
4W6V
-
?
A:
[15-484]
-----------------------------------------------------------------
G
H
-----
P
Y
P
L
S
-----
G
L
F
L
S
E
M
W
E
R
F
S
F
Y
G
I
R
P
L
-------
L
I
L
F
M
A
-
A
TVF
D
G
G
M
------
G
L
P
R
E
Q
A
S
A
I
V
G
I
F
A
G
---
S
M
Y
L
A
A
-
L
P
G
G
L
L
A
D
-
N
-
W
L
G
Q
Q
R
-----------
A
----------------
V
W
Y
G
S
I
L
I
---
A
L
G
H
L
S
I
A
-----------------
L
---------
S
A
-----------
F
---
F
G
N
D
L
F
---
F
I
G
L
V
---
F
I
V
L
G
----
T
----------------
G
L
F
K
-----
T
C
I
S
V
M
V
G
---
T
L
Y
K
P
GD
A
-
R
---
R
D
G
G
------------
F
S
L
F
Y
M
---
G
I
N
M
G
S
F
I
A
P
---
L
L
S
---
G
W
L
-----------
L
R
T
H
-------------------
G
W
H
W
G
---
F
G
--------
I
G
G
-
I
G
M
L
V
A
L
L
I
-------
F
-
R
-
G
F
A
I
P
A
M
-------
K
R
Y
D
A
E
---
V
G
L
--
D
S
S
W
-------
N
--------
K
--
P
--
T
---------------------------------------------------------------------------------------------G
R
W
V
T
A
I
M
A
V
V
V
V
I
I
A
L
I
S
Q
G
V
I
P
I
N
P
V
M
I
A
S
L
L
V
Y
V
I
A
A
S
V
T
L
Y
F
I
Y
L
F
-
A
F
A
K
M
S
R
K
D
R
----
A
---
R
L
L
V
C
F
I
L
L
V
S
A
------
A
F
F
W
S
A
-----
F
E
Q
K
P
T
S
F
N
L
F
A
N
D
Y
-------
T
D
R
M
VM
G
F
----------
E
----
I
P
----------
T
---
V
-
W
-----------
F
Q
S
I
N
A
L
F
I
I
L
L
A
P
V
-----
F
-------
S
W
-------
A
-------------------------------------------PS
S
I
T
K
F
V
I
--
G
I
----
L
C
A
--------
A
A
G
F
A
V
M
--
M
-------
Y
--
A
A
Q
H
V
L
S
S
G
GAG
V
S
------
P
L
------
W
L
V
-
M
S
I
L
L
L
T
L
G
E
L
---------
C
-
L
S
P
I
G
L
----------------------
A
T
M
T
L
L
A
------
P
D
R
M
-------
R
-----
G
Q
V
M
G
L
W
-
F
C
A
-
S
S
--
L
G
---
N
L
----
A
A
------
G
L
I
G
G
H
V
K
---
A
D
QL
D
-
M
L
P
T
L
F
A
R
C
-------
S
I
A
L
-------------------------------------------------------------
39
HHSearch
67.00
9%
-124
- C6 -
4UVM
5
?
A:
[11-468]
------------------------------------------------------------------------
P
R
Q
I
P
-----
Y
I
I
A
S
E
A
C
E
R
F
S
F
Y
G
M
R
N
I
-------
L
T
P
F
L
M
-
T
-----
A
L
LLSIP
E
E
L
R
G
A
V
A
K
D
V
F
H
S
F
V
I
---
G
V
Y
F
F
P
-
L
L
G
G
W
I
A
D
-
R
-
F
F
G
K
Y
N
-----------
T
----------------
I
L
W
L
S
L
I
Y
---
C
V
G
H
A
F
L
A
-----------------
I
---------
F
------------
E
---
H
S
V
Q
G
F
---
Y
T
G
L
F
---
L
I
A
L
G
----
S
----------------
G
G
I
K
-----
P
L
V
S
S
F
M
G
---
D
Q
F
D
Q
--
S
-
N
KSL
A
Q
K
A
------------
F
D
M
F
Y
F
---
T
I
N
F
G
S
F
F
A
S
---
L
S
M
---
P
L
L
-----------
L
K
N
F
-------------------
G
A
A
V
A
---
F
G
--------
I
P
G
-
V
L
M
F
V
A
T
V
F
-------
F
-
W
-
L
--
G
R
K
R
-------
Y
I
H
M
P
P
---
E
P
K
--
D
P
H
G
-------
F
L
P
V
I
R
S
A
L
L
--
T
KV
E
-----------------
G
KGN
I
G
L
V
L
A
L
I
G
G
V
S
A
A
Y
A
L
V
N
IPTLG
I
V
A
G
L
C
C
A
M
V
L
V
M
G
F
V
G
A
G
A
S
L
Q
L
E
RARK
S
H----------------
P
-------------------------------------------------
D
-
A
A
V
D
G
V
R
S
V
L
----
R
---
I
L
V
----
L
F
A
L
V
------
T
P
F
W
S
L
-----
F
D
Q
K
A
S
T
W
I
L
Q
A
N
D
M
-------
V
K
-----
P
Q
---------
W
----
F
E
----------
P
---
A
-
M
-----------
M
Q
A
L
N
P
L
L
V
M
L
L
I
P
F
-----
N
-------
N
F
-------
V
L
Y
P
A
I
E
R
M
G
V
K
L
T
A
-
L
-------------------------
R
K
------
M
G
A
--
G
I
----
A
I
T
--------
G
L
S
W
I
V
V
--
G
-------
T
--
I
Q
L
M
M
D
G
G
S
A
--
L
S
------
I
F
------
W
Q
I
-
L
P
Y
A
L
L
T
F
G
E
V
---------
L
-
V
S
A
T
G
L
----------------------
E
F
A
Y
S
Q
A
------
P
K
A
M
-------
K
-----
G
T
I
M
S
F
W
-
T
L
S
-
V
T
--
V
G
---
N
L
----
W
V
------
L
L
A
N
V
S
V
K
---
S
P
--
T
----------------------------------------------------------------------------------
29
HHSearch
66.33
11%
-118
- C6 -
4ZP0
3
MDFA_ECOLI
A:
[13-371]
----------------------------------------------------------------------------------
C
L
V
L
Y
E
F
S
T
Y
I
G
N
D
M
I
Q
P
G
-------
M
L
A
V
V
E
-------
Q
Y
------
Q
A
G
I
D
W
V
P
T
S
M
T
A
Y
L
A
---
G
G
M
F
L
Q
-
W
L
L
G
P
L
S
D
-
R
-
I
-
G
R
R
P
-----------
V
----------------
M
L
A
G
V
V
W
F
---
I
V
T
C
L
A
I
L
-----------------
L
---------
A
----------------
Q
N
I
E
Q
F
---
T
L
L
R
F
---
L
Q
G
I
S
----
L
----------------
C
F
I
G
-----
A
V
G
Y
A
A
I
R
---
E
S
F
E
E
--
A
-
V
---
C
I
K
I
------------
T
A
L
M
A
N
---
V
A
L
I
A
P
L
L
G
P
---
L
V
G
---
A
A
W
-----------
I
H
V
L
-------------------
P
W
E
G
M
---
F
V
--------
L
F
A
-
A
L
A
A
I
S
F
F
G
-------
L
-
Q
-
R
A
-
M
P
E
T
-------
A
T
R
I
G
----
E
------------------------------
K
-----------------
L
-------------------------------------------------
S
L
K
----
E
-----------------
L
-------------------------------------------------
G
-
R
D
Y
K
L
V
L
K
N
G
----
R
---
F
V
A
----
G
A
L
A
L
------
G
F
V
S
L
P
-----
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
-------
E
Q
-----
L
S
---------
S
----
Y
E
----------
Y
---
G
-
L
-----------
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
L
-----
L
-------
A
R
-------
L
T
--------
S
R
R
T
V
-
R
-------------------------
S
L
------
I
I
M
--
G
G
----
W
P
I
--------
M
I
G
L
L
V
A
--
A
A
A
T
V
I
--
S
--
S
-----------
H
A
------
Y
L
------
W
M
T
-
A
G
L
S
I
Y
A
F
G
I
G
---------
L
-
A
N
A
G
L
V
----------------------
R
-
L
T
L
F
A
------
S
D
M
S
-------
K
-----
G
T
V
S
A
A
M
-
G
M
L
-
Q
M
--
L
I
---
F
T
----
V
G
------
I
E
I
S
K
H
A
W
---
L
N
--
G
-
G
N
G
L
-----------------------------------------------------------------------------
16
Fugue
64.83
21%
-116
- C4 -
4Q4D
5
VIP2_HUMAN
A:
[7-323]
-------------------------------------
Q
I
V
V
G
I
C
S
M
A
K
K
S
K
S
K
----
P
M
K
E
I
L
E
R
I
S
-----
L
F
K
Y
I
-----
T
V
V
V
F
E
E
E
V
I
L
N
E
P
V
E
N
W
P
-------
L
C
D
C
L
I
S
F
---
H
S
K
G
------
F
--
P
L
D
K
A
V
A
Y
A
K
L
R
N
---
P
F
V
I
N
D
-
L
--
N
M
Q
Y
L
-
I
-
Q
-
D
R
R
E
-----------
V
----------------
Y
S
I
L
Q
A
E
G
---
I
L
L
P
-------------------------------------------------------------------------------------------
R
Y
A
I
-----
L
N
R
D
P
N
N
P
KEC
N
L
I
E
G
--
E
-
D
---
H
V
E
V
------------
N
G
E
V
F
Q
---
K
P
F
V
E
K
P
V
S
A
EDH
N
V
Y
---
I
Y
Y
-----------
P
T
S
A
G
-----
G
---------
G
---------------------------
S
Q
R
L
F
R
-------
K
-
I
-
G
--
S
R
S
S
-------
V
Y
S
P
E
S
---
N
V
R
--
K
-
T
G
-------
S
--------
Y
--
I
--
Y
-----------------
E
-------------------------------------------------
E
------------------------
F
-------------------------------------------------
M
-
P
T
D
G
T
D
V
K
V
Y
----
T
---
V
G
P
----
D
Y
--------------------------------
A
H
A
-------
E
A
R
K
--------------------------------------------------------
S
P
A
L
D
G
K
V
-----
E
-------
R
D
-------
S
E
--------
G
K
E
V
R
-
Y
-------------------------
P
V
------
I
L
N
--
A
R
----
E
K
L
--------
I
A
W
K
V
C
---
L
-------
A
--
F
-----------
K
----------------
Q
T
-
V
C
G
F
D
L
L
R
A
N
-----------------
G
----------------------
Q
S
Y
V
C
D
V
------
N
----------------
G
F
S
F
V
K
N
-
S
M
K
-
Y
Y
D
D
C
A
---
K
I
----
L
G
------
N
I
V
M
R
E
L
A
---
P
Q
--
F
-
H
I
P
W
S
----------------------------------------------------------------------------
24
HHSearch
63.74
11%
-120
- C6 -
4IKV
11
?
A:
[21-472]
------------------------------------------------------------------
H
-----
P
K
G
L
F
-----
T
L
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
I
-------
L
V
Y
Y
M
Y
-
Y
EVS
K
G
G
L
------
G
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
---
L
V
Y
M
S
G
-
I
I
G
G
W
L
A
D
-
R
V
F
-
G
T
S
R
-----------
A
----------------
V
F
Y
G
G
L
L
I
---
M
A
G
H
I
A
L
A
-----------------
I
---------
P
----------------
G
G
V
A
A
L
---
F
V
S
M
A
---
L
I
V
L
G
----
T
----------------
G
L
L
K
-----
P
N
V
S
S
I
V
G
---
D
M
Y
K
P
GD
D
-
R
---
R
D
A
G
------------
F
S
I
F
Y
M
---
G
I
N
L
G
A
F
L
A
P
---
L
V
V
---
G
T
A
-----------
G
M
K
Y
-------------------
N
F
H
L
G
---
F
G
--------
L
A
A
-
V
G
M
F
L
G
L
V
V
-------
F
-
V
-
A
--
T
R
K
K
-------
N
L
G
L
A
G
TYV
P
N
P
--
L
T
P
A
-------
E
--------
K
--
K
--
K
A
----------------
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
GWFT
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
---
M
Y
R
----
S
-----------------
P
-------------------------------------------------
K
-
T
T
A
E
E
R
S
R
V
I
----
A
---
Y
I
P
----
L
F
V
A
S
------
A
M
F
W
A
I
-----
Q
E
Q
G
S
T
I
L
A
N
Y
A
D
K
R
-------
T
Q
-----
L
D
---------
V
AG
I
H
L
S
----------
P
---
A
-
W
-----------
F
Q
S
L
N
P
L
F
I
I
I
L
A
P
V
-----
F
-------
A
W
-------
M
W
--------
V
K
L
G
K
-
R
-------------------------
Q
P
T
I
P
Q
K
-
F
A
L
--
G
L
----
L
F
A
--------
G
L
S
F
I
V
I
--
L
-------
V
--
P
G
H
L
S
GGGL---
V
H
------
P
I
------
W
L
V
-
L
S
Y
F
I
V
V
L
G
E
L
---------
C
-
L
S
P
V
G
L
----------------------
S
A
T
T
K
L
A
------
P
A
A
F
-------
S
-----
A
Q
T
M
S
L
W
-
F
L
S
-
N
A
--
A
A
---
Q
A
----
I
N
------
A
Q
L
V
R
F
Y
T
---
P
E
----
N
E
T
A
Y
F
G
T
I
-------
G
G
---------------------------------------------------------------
35
HHSearch
62.77
14%
-109
- C6 -
2GFP
-
EMRD_ECOLI
A:
[16-361]
--------------------------------------------------------------------------------------
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
-------
I
A
D
M
A
R
-------
D
L
------
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
---
T
Y
G
V
S
Q
-
L
F
Y
G
P
I
S
D
-
R
-
V
-
G
R
R
P
-----------
V
----------------
I
L
V
G
M
S
I
F
---
M
L
A
T
L
V
A
V
-----------------
T
---------
T
----------------
S
S
L
T
V
L
---
I
A
A
S
A
---
M
Q
G
M
G
----
T
----------------
G
V
G
G
-----
V
M
A
R
T
L
P
R
---
D
L
Y
E
R
--
T
-
Q
---
L
R
H
A
------------
N
S
L
L
N
M
---
G
I
L
V
S
P
L
L
A
P
---
L
I
G
---
G
L
L
-----------
D
T
M
W
-------------------
N
W
R
A
C
---
Y
L
--------
F
L
L
-
V
L
C
A
G
V
T
F
S
-------
M
-
A
-
R
W-
M
P
E
T
-------
R
P
V
D
A
----
P
---------------------------------------------------------------------------------------------------
R
T
----
R
-----------------
L
-------------------------------------------------
L
-
T
S
Y
K
T
L
F
G
N
S
----
G
---
F
N
C
----
Y
L
L
M
L
------
I
G
G
L
A
G
-----
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
-------
L
G
-----
L
S
---------
S
----
M
T
----------
V
---
S
-
I
-----------
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
-----
A
-------
G
R
-------
P
N
--------
K
R
F
S
T
-
L
-------------------------
M
W
------
Q
S
V
I
-
C
C
----
L
L
A
--------
G
L
L
M
W
I
P--
D
-------
W
F
G
V
-----------
M
N
------
V
W
------
T
L
L
-
V
P
A
A
L
F
F
F
G
A
G
---------
M
-
L
F
P
L
A
T
----------------------
S
G
A
M
E
P
F
------
P
-
F
L
-------
A
-----
G
T
A
G
A
L
V
-
G
G
L
-
Q
N
--
I
G
---
S
G
----
V
L
------
A
S
L
S
A
M
L
P
---
Q
T
--
G
----------------------------------------------------------------------------------
28
HHSearch
61.71
9%
-125
- C6 -
4TPH
3
?
A:
[9-452]
-----------------------------------------------------------------
S
K
-----
T
H
S
F
M
-----
T
V
S
L
I
E
L
W
E
R
F
G
Y
Y
G
M
Q
A
L
-------
I
V
Y
F
M
V
-
Q
-----
R
L
------
G
F
D
D
S
R
A
N
L
V
W
S
A
C
A
A
---
L
I
Y
V
S
P
-
A
I
G
G
W
V
G
D
-
K
-
I
L
G
T
K
R
-----------
T
----------------
M
L
L
G
A
G
I
L
---
S
V
G
Y
A
L
M
T
-----------------
V
---------
P
------------
T
---
E
N
T
W
F
M
---
F
S
A
L
G
---
V
I
V
V
G
----
N
----------------
G
L
F
K
-----
P
N
A
G
N
L
V
R
---
K
I
Y
E
----S
K
---
I
D
S
A
------------
F
T
I
Y
Y
M
---
A
V
N
V
G
S
T
F
S
M
---
L
L
T
---
P
W
I
-----------
K
D
Y
V
N
A
Q
Y
GN
E
---------
F
--
G
W
H
A
A
---
F
A
--------
V
C
C
-
V
G
I
L
V
G
L
G
N
-------
Y
-
A
-
L
--
M
H
K
S
-------
L
A
N
Y
G
S
---
E
P
D
T-
R
P
V
N
-------
K
--------
K
--
S
--
L
A
I
V
L
A
L
A
A
L
S
V
V
A
S
A
I
I
L
-------------------------------------------------
E
Y
E
----
D
V
A
R
V
F
V
Y
A
A
G
V
A
V
L
G
I
F
F
-------------------------------------------------
H
L-------
E
R
A
----
G
L
I
A
A
L
I
----
L
T
V
Q
T
------
V
F
F
F
I
F
-----
Y
Q
Q
M
S
T
S
L
A
L
F
A
L
R
N
-------
V
D
-----
W
D
FQVFGTHLW
T
----
W
S
----------
P
---
A
-
Q
-----------
F
Q
A
L
N
P
I
W
I
M
V
L
S
P
V
-----
L
-------
A
W
----------------------I
A
-------------------------
A
K
------
F
A
L
--
G
F
----
A
V
V
--------
A
I
G
F
F
I
Y
--
G
-------
F
--
A
GQFAVNGK---
T
S
------
S
W
------
V
M
I
-
W
G
Y
A
S
Y
S
L
G
E
L
---------
L
-
V
S
G
L
G
L
----------------------
A
M
I
A
R
---------------------------
M
M
G
A
Y
-
F
V
A
-
S
G
--
I
S
---
Q
Y
----
L
G
------
G
V
V
A
N
F
A
S
---
V
P
--
Q
-
D
--------------------------------------------------------------------------------