@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0062: (2016-04-19 )
MTRRTGQRWRGTLPGRRPWTRPAPATCRRHLAFVELRHYFARVMSSAIGSVARWIVPLLGVAAVASIGVIADPVRVVRAPALILVDAANPLAGKPFYVDPASAAMVAARNANPPNAELTSVANTPQSYWLDQAFPPATVGGTVARYTGAAQAAGAMPVLTLYGIPHRDCGSYASGGFATGTDYRGWIDAVASGLGSSPATIIVEPDALAMADCLSPDQRQERFDLVRYAVDTLTRDPAAAVYVDAGHSRWLSAEAMAARLNDVGVGRARGFSLNVSNFYTTDEEIGYGEAISGLTNGSHYVIDTSRNGAGPAPDAPLNWCNPSGRALGAPPTTATAGAHADAYLWIKRPGESDGTCGRGEPQAGRFVSQYAIDLAHNAGQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100........-------.110..--.....120...-......130.....--..140......-.---150-----.----......----.160.......170....---.-----.-----.-----180..-----..-.....190.---.---.------..-----.---.200.---......-------210.-------.----------.-....----.220.......230..-.....240........250-------.--------.--------.--------.....260.----.--.-..-.-.270......----------.-----280-------------.--------------.---------------------------......290...----..--.----.-.300.......310.-----------------------.-...-..320.......330...---....340.......350...-----------.-----------.----------------.--------------------------------.360---.........370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTRRTG
Q
R
WRGTLPGRRPWTRPA
P
A
T
C
R
R
H
L
A
F
V
E
L
R
H
Y
F
A
R
V
M
S
S
A
I
G
S
V
A
R
W
I
V
P
L
L
G
V
A
A
V
A
S
IGVIAD
P
V
R
V
VRA
P
A
L
I
L
V
DAANPLAGK
P
F
Y
VDP--A
S
A
A
M
V
AA-------RNANPP--NA
E
L
T
S
--VAN-T
P
Q
S
YWLDQAFPPA--TVGG
T
V
A
R
YTG-A---AQ------A----AGA
M
P
V
----
L
T
LYGIPHRDCGSYASGG---F-----A-----T-----G--TD-----Y
R
-
G
W
I
D
A
V
A
SG---L---G------SS-----
P
---
A
T
I
I
V---EPD
A
L
A
-------
M
A
-D-------C----------L-S
P
D
Q
----
R
Q
E
R
F
D
L
V
R
Y
A
V
D
T
LT-RDPA
A
A
-
V
Y
V
DAGHSRW
L
--------
S
--------
A
--------
E
--------
A
M
A
A
R
L
N
DV----G--V-GR-A-R
G
F
S
L
NVS
N
F
----------Y-----TT--------------D--------------E---------------------------EIGY
G
E
A
I
-
S
GL----TN--G----
S
-
H
Y
V
I
DTSRNGAGPAP-----------------------D-APL-NWCNPSGRALGAPPTTAT---AGAHA
D
A
Y
L
W
I
KRPGESDGT-----------C-----------G----------------R--------------------------------GE-----P
Q
A
G
R
F
V
S
Q
Y
A
I
D
LAHNAGQ
1
PsiBlast_PDB
98.62
100%
-82
- C4 -
1UOZ
6
?
A:
[23-315]
---------------------------------------------------------------------------------------
A
N
P
L
A
G
K
P
F
Y
V
D
P
--
A
S
A
A
M
V
A
A
-------
R
N
A
N
P
P
--
N
A
E
L
T
S
--
V
A
N
-
T
P
Q
S
Y
W
L
D
Q
A
F
P
P
A
--
T
V
G
G
T
V
A
R
Y
T
G
-
A
---
A
Q
------
A
----
A
G
A
M
P
V
----
L
T
L
Y
G
I
P
H
R
D
C
G
S
Y
A
S
G
G
---
F
-----
A
-----
T
-----
G
--
T
D
-----
Y
R
-
G
W
I
D
A
V
A
S
G
---
L
---
G
------
S
S
-----
P
---
A
T
I
I
V
---
E
P
D
A
L
A
-------
M
A
-
D
-------
C
----------
L
-
S
P
D
Q
----
R
Q
E
R
F
D
L
V
R
Y
A
V
D
T
L
T
-
R
D
P
A
A
A
-
V
Y
V
D
A
G
H
S
R
W
L
--------
S
--------
A
--------
E
--------
A
M
A
A
R
L
N
D
V
----
G
--
V
-
G
R
-
A
-
R
G
F
S
L
N
V
S
N
F
----------
Y
-----
T
T
--------------
D
--------------
E
---------------------------
E
I
G
Y
G
E
A
I
-
S
G
L
----
T
N
--
G
----
S
-
H
Y
V
I
D
T
S
R
N
G
A
G
P
A
P
-----------------------
D
-
A
P
L
-
N
W
C
N
P
S
G
R
A
L
G
A
P
P
T
T
A
T
---
A
G
A
H
A
D
A
Y
L
W
I
K
R
P
G
E
S
D
G
T
-----------
C
-----------
G
----------------
R
--------------------------------
G
E
-----
P
Q
A
G
R
F
V
S
Q
Y
A
I
D
L
A
H
N
A
G
Q
2
PsiBlast_PDB
98.16
100%
-82
- C4 -
1UP3
9
?
A:
[2-294]
---------------------------------------------------------------------------------------
A
N
P
L
A
G
K
P
F
Y
V
D
P
--
A
S
A
A
M
V
A
A
-------
R
N
A
N
P
P
--
N
A
E
L
T
S
--
V
A
N
-
T
P
Q
S
Y
W
L
D
Q
A
F
P
P
A
--
T
V
G
G
T
V
A
R
Y
T
G
-
A
---
A
Q
------
A
----
A
G
A
M
P
V
----
L
T
L
Y
G
I
P
H
R
D
C
G
S
Y
A
S
G
G
---
F
-----
A
-----
T
-----
G
--
T
D
-----
Y
R
-
G
W
I
D
A
V
A
S
G
---
L
---
G
------
S
S
-----
P
---
A
T
I
I
V
---
E
P
D
A
L
A
-------
M
A
-
D
-------
C
----------
L
-
S
P
D
Q
----
R
Q
E
R
F
D
L
V
R
Y
A
V
D
T
L
T
-
R
D
P
A
A
A
-
V
Y
V
D
A
G
H
S
R
W
L
--------
S
--------
A
--------
E
--------
A
M
A
A
R
L
N
D
V
----
G
--
V
-
G
R
-
A
-
R
G
F
S
L
N
V
S
N
F
----------
Y
-----
T
T
--------------
D
--------------
E
---------------------------
E
I
G
Y
G
E
A
I
-
S
G
L
----
T
N
--
G
----
S
-
H
Y
V
I
D
T
S
R
N
G
A
G
P
A
P
-----------------------
D
-
A
P
L
-
N
W
C
N
P
S
G
R
A
L
G
A
P
P
T
T
A
T
---
A
G
A
H
A
D
A
Y
L
W
I
K
R
P
G
E
S
D
G
T
-----------
C
-----------
G
----------------
R
--------------------------------
G
E
-----
P
Q
A
G
R
F
V
S
Q
Y
A
I
D
L
A
H
N
A
G
Q
22
HHSearch
97.44
97%
-80
- C4 -
1UOZ
6
?
A:
[18-315]
----------------------------------------------------------------------------------
E
G
R
H
-
A
N
P
L
A
G
K
P
F
Y
V
D
P
--
A
S
A
A
M
V
A
A
R
------
N
A
N
P
P
---
N
A
E
L
T
S
--
V
A
N
-
T
P
Q
S
Y
W
L
D
Q
A
F
P
P
A
--
T
V
G
G
T
V
A
R
Y
T
G
-
A
---
A
Q
------
A
----
A
G
A
M
P
V
----
L
T
L
Y
G
I
P
H
R
D
C
G
S
Y
A
S
G
G
---
F
-----
A
-----
T
-----
G
--
T
D
-----
Y
R
-
G
W
I
D
A
V
A
S
G
---
L
---
G
------
S
S
-----
P
---
A
T
I
I
V
---
E
P
D
A
L
A
-------
M
A
-
D
-------
C
----------
L
-
S
P
D
Q
----
R
Q
E
R
F
D
L
V
R
Y
A
V
D
T
L
T
-
R
D
P
A
A
A
-
V
Y
V
D
A
G
H
S
R
W
L
--------
S
--------
A
--------
E
--------
A
M
A
A
R
L
N
D
V
----
G
--
V
-
G
R
-
A
-
R
G
F
S
L
N
V
S
N
F
----------
Y
-----
T
T
--------------
D
--------------
E
---------------------------
E
I
G
Y
G
E
A
I
-
S
G
L
----
T
N
--
G
----
S
-
H
Y
V
I
D
T
S
R
N
G
A
G
P
A
P
-----------------------
D
-
A
P
L
-
N
W
C
N
P
S
G
R
A
L
G
A
P
P
T
T
A
T
---
A
G
A
H
A
D
A
Y
L
W
I
K
R
P
G
E
S
D
G
T
-----------
C
-----------
G
----------------
R
--------------------------------
G
E
-----
P
Q
A
G
R
F
V
S
Q
Y
A
I
D
L
A
H
N
A
G
Q
29
HHSearch
82.40
31%
-55
- C4 -
4B4H
-
?
A:
[141-556]
--------------------------------------------------------------------------------------
V
D
N
P
F
E
G
A
K
L
Y
V
N
P
--
V
W
S
A
K
A
A
A
-------
E
--------
P
G
G
S
A
--
V
A
N
-
E
S
T
A
V
W
L
D
R
I
G
A
I
E
GN---
M
G
L
R
D
H
L
E
-
E
---
A
V
R
Q
S
G
--
G
----
D
P
L
T
I
Q
----
V
V
I
Y
N
L
P
G
R
D
C
A
A
L
A
S
N
G
---
E
-----
L
-----
G
PDE--
L
--
D
R
-----
Y
K
S
E
Y
I
D
P
I
A
D
I
---
M
---
W
D
F
ADYE
N
L
-----
R
---
I
V
A
I
I
---
E
I
D
S
L
P
-------
N
L
-
V
-------
T
NVGGNGGT
E
L
C
A
Y
M
K
Q
----
N
G
G
Y
V
N
G
V
G
Y
A
L
R
K
L
G
-
E
I
P
N
V
Y
-
N
Y
I
D
A
A
H
H
G
W
I
--------
G
WDSN
F
G
P
S
V
--------
D
--------
I
F
Y
E
A
A
N
A
S
----
G
ST
V
-
D
Y
-
V
-
H
G
F
I
S
N
T
A
N
Y
----------
S
-----
A
T
--------------
V
--------------
E
PYLDVNGTVNGQLIRQSKWVDWNQYVD
E
L
S
F
V
Q
D
L
-
R
Q
A
L
I
A
K
G
F
RS
D
----
I
-
G
M
L
I
D
T
S
R
N
G
W
G
G
P
N
RPTGPSSSTD
L
N
T
Y
V
D
E
S
RIDRR
I
-
H
P
G
-
N
W
C
N
Q
A
G
A
G
L
G
E
R
P
T
V
N
P
----
A
P
G
V
D
A
Y
V
W
V
K
P
P
G
E
S
D
G
A
-----------
S
-----------
E
----------------
E
I
P
N
DEGKGFDRMCDPTYQGNARNGNNPSGALP
N
A
-----
P
I
S
G
H
W
F
S
A
Q
F
R
E
L
L
A
N
A
Y
P
4
PsiBlast_PDB
78.60
42%
-77
- C4 -
1TML
1
GUN2_THEFU
A:
[3-283]
---------------------------------------------------------------------------------------------
S
P
F
Y
V
N
P
N-
M
S
S
A
E
W
V
R
-------
N
N
P
N
D
P
--
R
T
P
V
I
R
D
R
I
A
S
-
V
P
Q
G
T
W
F
A
H
-
H
N
P
G
--
Q
I
T
G
Q
V
D
A
L
M
S
-
A
---
A
Q
------
A
----
A
G
K
I
P
I
----
L
V
V
Y
N
A
P
G
R
D
C
G
N
H
S
S
G
G
---
A
-----
P
-----
S
-----
H
--
S
A
-----
Y
R
-
S
W
I
D
E
F
A
A
G
---
L
---
K
------
N
R
-----
P
---
A
Y
I
I
V
---
E
P
D
L
I
S
-------
L
M
-
S
-------
S
----------
C
-
M
Q
H
V
----
Q
Q
E
V
L
E
T
M
A
Y
A
G
K
A
L
K
-
A
G
S
S
Q
A
R
I
Y
F
D
A
G
H
S
A
W
H
--------
S
--------
P
--------
A
--------
Q
M
A
S
W
L
Q
Q
A
----
D
--
I
-
S
N
S
A
-
H
G
I
A
T
N
T
S
N
Y
----------
R
-----
W
T
--------------
A
--------------
D
---------------------------
E
V
A
Y
A
K
A
V
L
S
A
I
----
G
N
--
P
----
S
L
R
A
V
I
D
T
S
R
N
G
N
G
P
A
G
-----------------------
N
-----
E
W
C
D
P
S
G
R
A
I
G
T
P
S
T
T
N
T
---
G
D
P
M
I
D
A
F
L
W
I
K
L
P
G
E
A
D
G
------------
C
-----------
I
----------------
A
--------------------------------
G
--------
A
G
Q
F
V
P
Q
A
A
Y
E
M
A
-----
7
PsiBlast_PDB
77.98
41%
-82
- C4 -
2BOG
2
GUN2_THEFU
X:
[3-283]
---------------------------------------------------------------------------------------------
S
P
F
Y
V
N
P
N-
M
S
S
A
E
W
V
R
-------
N
N
P
N
D
P
--
R
T
P
V
I
R
DR
I
A
S
-
V
P
Q
G
T
W
F
A
H
-
H
N
P
G
--
Q
I
T
G
Q
V
D
A
L
M
S
-
A
---
A
Q
------
A
----
A
G
K
I
P
I
----
L
V
V
S
N
A
P
G
R
D
C
G
---------
A
-----
P
-----
S
-----
H
--
S
A
-----
Y
R
-
S
W
I
D
E
F
A
A
G
---
L
---
K
------
N
R
-----
P
---
A
Y
I
I
V
---
E
P
D
L
I
S
-------
L
M
-
S
-------
S
----------
C
-
M
Q
H
V
----
Q
Q
E
V
L
E
T
M
A
Y
A
G
K
A
L
K
-
A
G
S
S
Q
A
R
I
Y
F
D
A
G
H
S
A
W
H
--------
S
--------
P
--------
A
--------
Q
M
A
S
W
L
Q
Q
A
----
D
--
I
-
S
N
S
A
-
H
G
I
A
T
N
T
S
N
Y
----------
R
-----
W
T
--------------
A
--------------
D
---------------------------
E
V
A
Y
A
K
A
V
L
S
A
I
----
G
N
--
P
----
S
L
R
A
V
I
D
T
S
R
N
G
N
G
P
A
G
-----------------------
N
-----
E
W
C
D
P
S
G
R
A
I
G
T
P
S
T
T
N
T
---
G
D
P
M
I
D
A
F
L
W
I
K
L
P
G
E
A
D
G
------------
C
-----------
I
----------------
A
--------------------------------
G
--------
A
G
Q
F
V
P
Q
A
A
Y
E
M
A
-----
5
PsiBlast_PDB
77.92
41%
-77
- C4 -
2BOE
-
GUN2_THEFU
X:
[3-283]
---------------------------------------------------------------------------------------------
S
P
F
Y
V
N
P
N-
M
S
S
A
E
W
V
R
-------
N
N
P
N
D
P
--
R
T
P
V
I
R
DR
I
A
S
-
V
P
Q
G
T
W
F
A
H
-
H
N
P
G
--
Q
I
T
G
Q
V
D
A
L
M
S
-
A
---
A
Q
------
A
----
A
G
K
I
P
I
----
L
V
V
S
N
A
P
G
R
D
C
G
----
G
G
---
A
-----
P
-----
S
-----
H
--
S
A
-----
Y
R
-
S
W
I
D
E
F
A
A
G
---
L
---
K
------
N
R
-----
P
---
A
Y
I
I
V
---
E
P
D
L
I
S
-------
L
M
-
S
-------
S
----------
C
-
M
Q
H
V
----
Q
Q
E
V
L
E
T
M
A
Y
A
G
K
A
L
K
-
A
G
S
S
Q
A
R
I
Y
F
D
A
G
H
S
A
W
H
--------
S
--------
P
--------
A
--------
Q
M
A
S
W
L
Q
Q
A
----
D
--
I
-
S
N
S
A
-
H
G
I
A
T
N
T
S
N
Y
----------
R
-----
W
T
--------------
A
--------------
D
---------------------------
E
V
A
Y
A
K
A
V
L
S
A
I
----
G
N
--
P
----
S
L
R
A
V
I
D
T
S
R
N
G
N
G
P
A
G
-----------------------
N
-----
E
W
C
D
P
S
G
R
A
I
G
T
P
S
T
T
N
T
---
G
D
P
M
I
D
A
F
L
W
I
K
L
P
G
E
A
D
G
------------
C
-----------
I
----------------
A
--------------------------------
G
--------
A
G
Q
F
V
P
Q
A
A
Y
E
M
A
-----
3
PsiBlast_PDB
77.69
42%
-84
- C4 -
2BOD
2
GUN2_THEFU
X:
[3-283]
---------------------------------------------------------------------------------------------
S
P
F
Y
V
N
P
N-
M
S
S
A
E
W
V
R
-------
N
N
P
N
D
P
--
R
T
P
V
I
R
DR
I
A
S
-
V
P
Q
G
T
W
F
A
H
-
H
N
P
G
--
Q
I
T
G
Q
V
D
A
L
M
S
-
A
---
A
Q
------
A
----
A
G
K
I
P
I
----
L
V
V
Y
N
A
P
G
R
D
C
G
---------
A
-----
P
-----
S
-----
H
--
S
A
-----
Y
R
-
S
W
I
D
E
F
A
A
G
---
L
---
K
------
N
R
-----
P
---
A
Y
I
I
V
---
E
P
D
L
I
S
-------
L
M
-
S
-------
S
----------
C
-
M
Q
H
V
----
Q
Q
E
V
L
E
T
M
A
Y
A
G
K
A
L
K
-
A
G
S
S
Q
A
R
I
Y
F
D
A
G
H
S
A
W
H
--------
S
--------
P
--------
A
--------
Q
M
A
S
W
L
Q
Q
A
----
D
--
I
-
S
N
S
A
-
H
G
I
A
T
N
T
S
N
Y
----------
R
-----
W
T
--------------
A
--------------
D
---------------------------
E
V
A
Y
A
K
A
V
L
S
A
I
----
G
N
--
P
----
S
L
R
A
V
I
D
T
S
R
N
G
N
G
P
A
G
-----------------------
N
-----
E
W
C
D
P
S
G
R
A
I
G
T
P
S
T
T
N
T
---
G
D
P
M
I
D
A
F
L
W
I
K
L
P
G
E
A
D
G
------------
C
-----------
I
----------------
A
--------------------------------
G
--------
A
G
Q
F
V
P
Q
A
A
Y
E
M
A
-----
25
HHSearch
77.19
26%
-58
- C4 -
3A9B
2
?
A:
[12-377]
--------------------------------------------------------------------------------------
S
V
N
P
Y
I
G
R
S
P
L
V
I
K
--
S
Y
A
E
K
L
E
E
T
I
A
Y
F
E
A
Q
G
D
E
L
N
--
A
A
R
T
R
T
--
V
Q
G
-
I
P
T
F
A
W
I
S
D
S
A
T
I
D
--
T
I
Q
P
L
I
A
D
A
V
A
-
H
---
Q
E
A
S
----
G
----
E
Q
V
L
V
Q
----
L
V
I
Y
N
L
P
D
R
D
C
A
A
K
A
S
D
G
---
E
-----
F
HLDDD
G
-----
A
--
N
K
-----
Y
R
-
A
Y
V
D
R
I
V
A
E
---
L
---
S
------
T
A
D
A
D
K
L
H
---
F
S
I
V
L
---
E
P
D
S
L
G
-------
N
M
-
V
TNMHV
P
K
C
----------
Q
-
G
A
------
A
T
A
Y
K
E
G
I
A
Y
T
I
A
S
L
Q
--
K
P
N
I
D
-
L
Y
I
D
A
A
H
G
G
W
L
--------
G
--------
W
NDN
L
R
P
S
A
E
--------
I
F
K
E
T
L
D
L
A
R
Q
I
T
P
--
N
-
A
T
-
V
-
R
G
L
A
I
N
V
S
N
Y
----------
N
-----
P
Y
--------------
K
TRAREDYTEWNNAY
D
---------------------------
E
W
N
Y
V
K
T
L
-
T
P
H
L
Q
A
V
G
F
--
P
----
A
-
Q
F
I
V
D
Q
G
R
S
G
R
E
G
I
R
-----------------------
T
-
E
W
G
-
Q
W
C
N
I
R
N
A
G
F
G
I
R
P
T
T
D
Q
AIV
D
S
A
N
V
D
A
I
V
W
V
K
P
G
G
E
S
D
G
T
-----------
S
DVNAVRFDENC
R
SPASH-----------
V
--------------------------------
P
A
-----
P
E
A
G
E
W
F
N
E
F
V
V
N
L
V
I
N
A
N
P
6
PsiBlast_PDB
77.16
41%
-82
- C4 -
2BOF
1
GUN2_THEFU
X:
[3-283]
---------------------------------------------------------------------------------------------
S
P
F
Y
V
N
P
N-
M
S
S
A
E
W
V
R
-------
N
N
P
N
D
P
--
R
T
P
V
I
R
DR
I
A
S
-
V
P
Q
G
T
W
F
A
H
-
H
N
P
G
--
Q
I
T
G
Q
V
D
A
L
M
S
-
A
---
A
Q
------
A
----
A
G
K
I
P
I
----
L
V
V
S
N
A
P
G
R
D
C
G
---------
A
-----
P
-----
S
-----
H
--
S
A
-----
Y
R
-
S
W
I
D
E
F
A
A
G
---
L
---
K
------
N
R
-----
P
---
A
Y
I
I
V
---
E
P
D
L
I
S
-------
L
M
-
S
-------
S
----------
C
-
M
Q
H
V
----
Q
Q
E
V
L
E
T
M
A
Y
A
G
K
A
L
K
-
A
G
S
S
Q
A
R
I
Y
F
D
A
G
H
S
A
W
H
--------
S
--------
P
--------
A
--------
Q
M
A
S
W
L
Q
Q
A
----
D
--
I
-
S
N
S
A
-
H
G
I
A
T
N
T
S
N
Y
----------
R
-----
W
T
--------------
A
--------------
D
---------------------------
E
V
A
Y
A
K
A
V
L
S
A
I
----
G
N
--
P
----
S
L
R
A
V
I
D
T
S
R
N
G
N
G
P
A
G
-----------------------
N
-----
E
W
C
D
P
S
G
R
A
I
G
T
P
S
T
T
N
T
---
G
D
P
M
I
D
A
F
L
W
I
K
L
P
G
E
A
D
G
------------
C
-----------
I
----------------
A
--------------------------------
G
--------
A
G
Q
F
V
P
Q
A
A
Y
E
M
A
-----
24
HHSearch
76.58
30%
-58
- C4 -
3VOG
1
?
A:
[4-360]
------------------------------------------------------------------------------------
P
S
T
G
N
P
F
E
G
Y
D
I
Y
L
S
P
--
Y
Y
A
E
E
V
E
A
A
A
A
M
---
I
D
D
P
V
L
--
K
A
K
A
L
K
--
V
K
E
-
I
P
T
F
I
W
F
D
V
V
R
K
T
------
P
D
L
G
R
Y
L
A
-
D
---
A
T
A
I
Q
Q
R
T
G
----
R
K
Q
L
V
Q
----
I
V
V
Y
D
L
P
D
R
D
C
A
A
A
A
S
N
G
---
E
-----
F
SLADG
G
-----
M
--
E
K
-----
Y
K
-
D
Y
V
D
R
L
A
S
E
---
I
---
R
K
Y
P---
D
V
-----
R
---
I
V
A
V
I
---
E
P
D
S
L
A
-------
N
M
-
V
TNMNV
A
K
C
----------
R
-
G
A
------
E
A
A
Y
K
E
G
V
I
Y
A
L
R
Q
L
S
--
A
L
G
V
Y
-
S
Y
V
D
A
G
H
A
G
W
L
--------
G
WNAN
L
A
P
S
A
--------
R
--------
L
F
A
Q
I
Y
K
D
A
----
G
--
R
S
A
F
-
I
-
R
G
L
A
T
N
V
S
N
Y
----------
N
-----
A
L
--------------
S
ATTRDPVTQGNDNY
D
---------------------------
E
L
R
F
I
N
A
L
-
A
P
L
L
R
N
E
G
W
--
D
----
A
-
K
F
I
V
D
Q
G
R
S
G
V
Q
N
I
R
-----------------------
Q
-
E
W
G
-
N
W
C
N
V
Y
G
A
G
F
G
M
R
P
T
L
N
T
---
P
S
S
A
I
D
A
I
V
W
I
K
P
G
G
E
A
D
G
T
-----------
S
-----------
D
TSAPRYDTHCGKSDSH
K
--------------------------------
P
A
-----
P
E
A
G
T
W
F
Q
E
Y
F
V
N
L
V
K
N
A
N
P
20
PsiBlast_PDB
75.34
28%
-60
- C4 -
3VOG
1
?
A:
[8-359]
----------------------------------------------------------------------------------------
N
P
F
E
G
Y
D
I
Y
L
S
P
Y
Y
A
E
E
V
E
A
A
A
-------
A
M
I
D
D
P
V
L
K
A
K
A
L
K
--
V
K
E
-
I
P
T
F
I
W
F
D
V
V
R
K
T
P
--
D
L
G
R
Y
L
A
D
A
T
A
-
I
---
Q
Q
------
R
----
T
G
R
K
Q
L
V
Q
--
I
V
V
Y
D
L
P
D
R
D
C
A
A
A
A
S
N
G
---
E
-----
F
-----
S
-----
L
--
A
D
G
G
M
E
K
Y
K
-
D
Y
V
D
R
L
A
S
E
---
I
---
R
------
K
Y
-----
P
---
D
V
R
I
V
A
V
I
E
P
D
S
L
A
N
M
V
TNMN
V
A
-
K
-------
C
----------
R
-
G
A
E
A
----
A
Y
K
--
E
G
V
I
Y
A
L
R
Q
L
S
-
A
-
L
G
V
Y
-
S
Y
V
D
A
G
H
A
G
W
L
GWNAN
L
A
P
S
--------
A
--------
R
--------
L
F
A
Q
I
Y
K
D
A
----
G
R-
S
-
A
F
-
I
-
R
G
L
A
T
N
V
S
N
Y
----------
N
A
LSAT
T
R
--------------
D
PVTQGNDNY-----
D
---------------------------
E
L
R
F
I
N
A
L
-
A
P
L
----
L
R
--
N
E
GWD
A
-
K
F
I
V
D
Q
G
R
S
G
V
Q
N
I
R
-----------------------
Q
-
E
W
G
-
N
W
C
N
V
Y
G
A
G
F
G
M
R
P
T
L
N
T
---
P
S
S
A
I
D
A
I
V
W
I
K
P
G
G
E
A
D
G
T
SDTSAPRYDTH
C
-----------
G
----------------
K
--------------------------------
S
D
SHKPA
P
E
A
G
T
W
F
Q
E
Y
F
V
N
L
V
K
N
A
N
-
23
HHSearch
75.17
41%
-77
- C4 -
2BOG
2
GUN2_THEFU
X:
[2-286]
--------------------------------------------------------------------------------------------
D
S
P
F
Y
V
N
P
--
N
M
S
S
A
E
W
V
RNN----
P
N
D
P
R
T
--
P
V
I
R
D
R
--
I
A
S
-
V
P
Q
G
T
W
F
A
H
H
N
-
P
G
--
Q
I
T
G
Q
V
D
A
L
M
S
-
A
---
A
Q
------
A
----
A
G
K
I
P
I
----
L
V
V
S
N
A
P
G
R
D
C
G
---------
A
-----
P
-----
S
-----
H
--
S
A
-----
Y
R
-
S
W
I
D
E
F
A
A
G
---
L
---
K
------
N
R
-----
P
---
A
Y
I
I
V
---
E
P
D
L
I
S
-------
L
M
S
S
-------
C
----------
M
--
Q
H
V
----
Q
Q
E
V
L
E
T
M
A
Y
A
G
K
A
L
K
A
G
S
S
Q
A
R
-
I
Y
F
D
A
G
H
S
A
W
H
--------
S
--------
P
--------
A
--------
Q
M
A
S
W
L
Q
Q
A
----
D
--
I
S
N
S
-
A
-
H
G
I
A
T
N
T
S
N
Y
----------
R
-----
W
T
--------------
A
--------------
D
---------------------------
E
V
A
Y
A
K
A
V
-
L
S
A
----
I
G
NP
S
----
L
-
R
A
V
I
D
T
S
R
N
G
N
G
P
A
---------------------------
G
N
-
E
W
C
D
P
S
G
R
A
I
G
T
P
S
T
T
N
T
---
G
D
P
M
I
D
A
F
L
W
I
K
L
P
G
E
A
D
G
C
-----------
I
-----------
A
---------------------------------------------------------
G
A
G
Q
F
V
P
Q
A
A
Y
E
M
A
I
A
A
--
26
HHSearch
75.08
29%
-60
- C4 -
1DYS
-
GUN6_HUMIN
A:
[3-344]
---------------------------------------------------------------------------------------
G
N
P
F
S
G
R
T
L
L
V
N
S
--
D
Y
S
S
K
L
D
Q
T
R
Q
A
F
L
S
R
G
D
Q
T
N
--
A
A
K
V
K
Y
--
V
Q
E
K
V
G
T
F
Y
W
I
S
N
I
F
L
L
R
--
D
I
D
V
-
A
I
Q
N
A
R
-
A
---
A
K
A
R
----
G
----
E
N
P
I
V
G
----
L
V
L
Y
N
L
P
D
R
D
C
S
A
G
E
S
S
G
---
E
-----
L
-----
K
LSQN
G
L
--
N
R
-----
Y
K
N
E
Y
V
N
P
F
A
Q
K
---
L
---
K
A
A
S---
D
V
-----
Q
---
F
A
V
I
L
---
E
P
D
A
I
G
-------
N
M
-
V
-------
T
GTS
A
F
-----
C
-
R
N
-
A
----
R
G
P
Q
Q
E
A
I
G
Y
A
I
S
Q
L
Q
--
A
S
H
I
H
-
L
Y
L
D
V
A
N
G
G
W
L
--------
G
WADK
L
E
P
T
A
--------
Q
--------
E
V
A
T
I
L
Q
K
A
----
G
--
N
N
A
K
-
I
-
R
G
F
S
S
N
V
S
N
Y
----------
N
-----
P
Y
STSNPPPYTSGSPS
P
--------------
D
---------------------------
E
S
R
Y
A
T
N
I
-
A
N
A
M
R
Q
R
G
L
--
P
----
T
-
Q
F
I
I
D
Q
S
R
V
A
L
S
G
A
R
-----------------------
S
-
E
W
G
-
Q
W
C
N
V
N
P
A
G
F
G
Q
P
F
T
T
N
T
---
N
N
P
N
V
D
A
I
V
W
V
K
P
G
G
E
S
D
G
Q
-----------
C
-----------
G
----------------
M
G-------------------------------
G
A
-----
P
A
A
G
M
W
F
D
A
Y
A
Q
M
L
T
Q
N
A
H
D
21
PsiBlast_CBE
72.31
39%
-82
- C4 -
3RPT
1
GUN2_THEFU
A:
[3-271]
----------------------------------------------------------------------------------------------
P
F
Y
V
N
P
N-
M
S
S
A
E
W
V
R
-------
N
N
P
N
D
P
--
R
T
P
V
I
R
D
R
I
A
S
-
V
P
Q
G
T
W
H
N
Q
-
H
-----
Q
I
T
G
Q
V
D
A
L
M
S
-
A
---
A
Q
------
A
----
A
G
K
I
P
I
----
L
V
V
----
N
P
------------
F
-----
E
-----
E
-----
G
----------
K
-
Q
W
I
D
E
F
A
A
G
---
L
---
K
------
N
R
-----
P
---
A
Y
I
I
V
---
D
P
G
---------------------------------------------
A
W
R
F
A
A
Y
A
G
K
A
L
K
-
A
G
S
S
Q
A
R
I
Y
F
D
A
G
H
S
A
W
H
--------
S
--------
P
--------
A
--------
Q
M
A
A
A
L
Q
R
A
----
D
--
I
-
S
N
S
A
-
H
G
I
A
T
N
T
S
N
Y
----------
R
-----
W
T
--------------
A
--------------
D
---------------------------
E
V
A
Y
A
K
A
V
L
S
A
I
----
G
N
--
P
----
S
L
R
A
V
I
D
T
S
R
N
G
N
G
P
A
G
-----------------------
N
-
E
S
----
C
D
P
S
G
R
A
I
G
T
P
S
T
T
N
T
---
G
D
P
M
I
D
A
F
L
W
I
K
L
P
G
E
A
D
G
------------
C
-----------
I
----------------
A
--------------------------------
G
--------
A
G
Q
F
V
P
Q
A
A
Y
E
M
A
-----
28
HHSearch
72.22
27%
-49
- C4 -
4AU0
13
GUX2_HYPJE
A:
[3-360]
------------------------------------------------------------------------------------
T
Y
S
G
N
P
F
V
G
V
T
P
W
A
N
A
--
Y
Y
A
S
E
V
S
S
LAIP---
S
L
T
G
A
M
--
A
T
A
A
A
A
--
V
A
K
-
V
P
S
F
M
W
L
D
T
L
D
K
T
P
--
L
M
E
Q
T
L
A
D
I
R
T
A
N
---
K
N
------
G
----
G
N
Y
A
G
Q
----
F
V
V
Y
D
L
P
D
R
D
C
A
A
L
A
S
N
G
---
E
-----
Y
SIADG
G
-----
V
--
A
K
-----
Y
K
-
N
Y
I
D
T
I
R
Q
I
---
V
V
E
Y
S
------
D
I
-----
R
---
T
L
L
V
I
---
E
P
A
S
L
A
-------
N
L
-
V
-------
T
NLGT
P
K
----
C
-
A
N
-
A
----
Q
S
A
Y
L
E
C
I
N
Y
A
V
T
Q
L
N
--
L
P
N
V
A
-
M
Y
L
D
A
G
H
A
G
W
L
--------
G
--------
W
--------
P
AN
Q
D
P
A
A
Q
L
F
A
N
V
Y
K
N
A
----
S
S-
P
-
R
A
-
L
-
R
G
L
A
T
N
V
A
N
Y
----------
N
-----
G
W
--------------
N
ITSPPSYTQGNAVY
N
---------------------------
E
K
L
Y
I
H
A
I
-
G
P
L
L
A
N
H
G
W
S-
N
----
A
-
F
F
I
T
D
Q
G
R
S
G
K
Q
P
T
G
-----------------------
Q
Q
Q
W
G
-
D
W
C
N
V
I
G
T
G
F
G
I
R
P
S
A
N
T
---
G
D
S
L
L
D
S
F
V
W
V
K
P
G
G
E
C
D
G
T
-----------
S
-----------
D
----------------
S
SAPRFDSHCALPDALQ----------------
P
A
-----
P
Q
A
G
A
W
F
Q
A
Y
F
V
Q
L
L
T
N
A
N
P
27
HHSearch
72.20
29%
-47
- C4 -
1OC7
11
GUX6_HUMIN
A:
[3-362]
-------------------------------------------------------------------------------------
Y
N
G
N
P
F
E
G
V
Q
L
W
A
N
N
--
Y
Y
R
S
E
V
H
T
LAIPQ--
I
T
D
P
A
L
--
R
A
A
A
S
A
--
V
A
E
-
V
P
S
F
Q
W
L
D
R
N
V
T
V
D
-----
T
L
L
V
Q
T
L
S
-
E
I
R
E
A
N
------
Q
A
GAN
P
Q
Y
A
A
Q
----
I
V
V
Y
D
L
P
D
R
D
C
A
A
A
A
S
N
G
---
E
WAIAN
N
-----
G
-----
V
--
N
N
-----
Y
K
-
A
Y
I
N
R
I
R
E
I
L
I
S
F
---
S
------
D
V
-----
R
---
T
I
L
V
I
---
E
P
D
S
L
A
-------
N
M
-
V
-------
T
NMNV
P
K
----
C
-
S
G
-
A
----
A
S
T
Y
R
E
L
T
I
Y
A
L
K
Q
L
D
--
L
P
H
V
A
-
M
Y
M
D
A
G
H
A
G
W
L
--------
G
--------
W
PAN
I
Q
P
A
A
E
--------
L
F
A
K
I
Y
E
D
A
----
G
--
K
P
R
A
-
V
-
R
G
L
A
T
N
V
A
N
Y
----------
N
-----
A
W
SVSSPPPYTSPNPN
Y
--------------
D
---------------------------
E
K
H
Y
I
E
A
F
-
R
P
L
L
E
A
R
G
F
--
P
----
A
-
Q
F
I
V
D
Q
G
R
S
G
K
Q
P
T
G
-----------------------
Q
K
E
W
G
-
H
W
C
N
A
I
G
T
G
F
G
M
R
P
T
A
N
T
---
G
H
Q
Y
V
D
A
F
V
W
V
K
P
G
G
E
C
N
G
T
-----------
S
DTTAARYDYHC
G
----------------
L
EDALK---------------------------
P
A
-----
P
E
A
G
Q
W
F
N
E
Y
F
I
Q
L
L
R
N
A
N
P
17
PsiBlast_PDB
71.70
28%
-65
- C4 -
1OC5
9
GUX6_HUMIN
A:
[46-361]
-----------------------------------------------------------------------------------------------------------------------------------------
V
P
S
F
Q
W
L
D
R
N
V
T
V
D
--
T
L
L
V
Q
T
L
S
E
I
R
-
E
---
A
N
------
Q
----
A
G
A
N
P
Q
Y
A
A
Q
I
V
V
Y
D
L
P
D
R
D
C
A
A
A
A
S
N
G
EWA
I
-----
A
-----
N
-----
N
G
V
N
N
-----
Y
K
-
A
Y
I
N
R
I
R
E
I
---
L
---
I
------
S
F
-----
S
D
V
R
T
I
L
V
I
---
E
P
D
S
L
A
N
------
M
V
-
T
-------
N
----------
M
-
N
V
P
K
C
S
G
A
A
S
T
Y
R
E
L
T
I
Y
A
L
K
Q
L
D
-
L
-
P
H
V
A
-
M
Y
M
D
A
G
H
A
G
W
L
GWPAN
I
Q
P
A
--------
A
--------
E
--------
L
F
A
K
I
Y
E
D
A
----
G
--
K
-
P
R
-
A
V
R
G
L
A
T
N
V
A
N
Y
N
A
WSVSSPPP
Y
-----
T
S
--------------
P
NPNY----------
D
---------------------------
E
K
H
Y
I
E
A
F
-
R
P
L
----
L
E
--
A
R
GFP
A
-
Q
F
I
V
D
Q
G
R
S
G
K
Q
P
T
G
-----------------------
Q
-
K
E
W
G
H
W
C
N
A
I
G
T
G
F
G
M
R
P
T
A
N
T
---
G
H
Q
Y
V
D
A
F
V
W
V
K
P
G
G
E
C
N
G
T
SDTTAARYDYH
C
-----------
G
LEDAL-----------
K
--------------------------------
P
A
-----
P
E
A
G
Q
W
F
N
E
Y
F
I
Q
L
L
R
N
A
N
-
12
PsiBlast_PDB
71.47
29%
-57
- C4 -
1OCB
7
GUX6_HUMIN
A:
[44-359]
-----------------------------------------------------------------------------------------------------------------------------------------
V
P
S
F
Q
W
L
D
R
N
V
T
V
D
--
T
L
L
V
Q
T
L
S
E
I
R
-
E
---
A
N
------
Q
----
A
G
A
N
P
Q
Y
A
A
Q
I
V
V
Y
D
L
P
D
R
D
C
A
A
A
A
S
N
G
EWA
I
-----
A
-----
N
-----
N
G
V
N
N
-----
Y
K
-
A
Y
I
N
R
I
R
E
I
---
L
---
I
------
S
F
-----
S
D
V
R
T
I
L
V
I
---
E
P
D
S
L
A
N
------
M
V
-
T
-------
N
----------
M
-
N
V
P
K
C
S
G
A
A
S
T
Y
R
E
L
T
I
Y
A
L
K
Q
L
D
-
L
-
P
H
V
A
-
M
Y
M
D
A
G
H
A
G
W
L
GWPAN
I
Q
P
A
--------
A
--------
E
--------
L
F
A
K
I
Y
E
D
A
----
G
--
K
-
P
R
-
A
V
R
G
L
A
T
N
V
A
N
Y
N
A
WSVSSPPP
Y
-----
T
S
--------------
P
NPNY----------
D
---------------------------
E
K
H
Y
I
E
A
F
-
R
P
L
----
L
E
--
A
R
GFP
A
-
Q
F
I
V
D
Q
G
R
S
G
K
Q
P
T
G
-----------------------
Q
-
K
E
W
G
H
W
C
N
A
I
G
T
G
F
G
M
R
P
T
A
N
T
---
G
H
Q
Y
V
D
A
F
V
W
V
K
P
G
G
E
C
D
G
T
SDTTAARYDYH
C
-----------
G
----------------
L
--------------------------------
E
D
ALKPA
P
E
A
G
Q
W
F
N
E
Y
F
I
Q
L
L
R
N
A
N
-
15
PsiBlast_PDB
71.39
29%
-58
- C4 -
1GZ1
5
GUX6_HUMIN
A:
[44-359]
-----------------------------------------------------------------------------------------------------------------------------------------
V
P
S
F
Q
W
L
D
R
N
V
T
V
D
--
T
L
L
V
Q
T
L
S
E
I
R
-
E
---
A
N
------
Q
----
A
G
A
N
P
Q
Y
A
A
Q
I
V
V
Y
D
L
P
D
R
D
C
A
A
A
A
S
N
G
EWA
I
-----
A
-----
N
-----
N
G
V
N
N
-----
Y
K
-
A
Y
I
N
R
I
R
E
I
---
L
---
I
------
S
F
-----
S
DVR
T
I
L
V
I
---
E
P
D
S
L
A
N
------
M
V
-
T
-------
N
----------
M
-
N
V
P
K
C
S
G
A
A
S
T
Y
R
E
L
T
I
Y
A
L
K
Q
L
D
-
L
-
P
H
V
A
-
M
Y
M
D
A
G
H
A
G
W
L
GWPAN
I
Q
P
A
--------
A
--------
E
--------
L
F
A
K
I
Y
E
D
A
----
G
--
K
-
P
R
-
A
V
R
G
L
A
T
N
V
A
N
Y
N
A
WSVSSPPP
Y
-----
T
S
--------------
P
NPNY----------
D
---------------------------
E
K
H
Y
I
E
A
F
-
R
P
L
----
L
E
--
A
R
GFP
A
-
Q
F
I
V
D
Q
G
R
S
G
K
Q
P
T
G
-----------------------
Q
-
K
E
W
G
H
W
C
N
A
I
G
T
G
F
G
M
R
P
T
A
N
T
---
G
H
Q
Y
V
D
A
F
V
W
V
K
P
G
G
E
C
D
G
T
SDTTAARYAYH
C
-----------
G
----------------
L
--------------------------------
E
D
ALKPA
P
E
A
G
Q
W
F
N
E
Y
F
I
Q
L
L
R
N
A
N
-