@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0063: (2016-04-19 )
MAREISRQTFLRGAAGALAAGAVFGSVRATADPAASGWEALSSALGGKVLQPDDGPQFATAKQVFNTNYNGYTPAVIVTPTSQLDVQKAMAFAAANNLKVAPRGGGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTVTPATGLYAMHQVLAAAGRGIPTGTCPTVGVAGHALGGGLGANSRHAGLLCDQLTSASVVLPSGQAVTASATDHPDLFWALRGGGGGNFGVTTSLTFATFPSGDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGSWALADATVDPLGTHCRILATCPAGSGGSVAAAIVSAVGTQPTGTENHTFNYLDLVRYLAVGNLNPSPLGYVGGSDVFTTITPATAQGIASAVDAFPRGAGRMLAIMHALDGALATVSPGATAFPWRRQSALVQWYVETSGSPSEATSWLNTAHQAVRAYSVGGYVNYLEVNQPPARYFGPNLSRLSAVRQKYDPSRVMFSGLNF
Atome Classification :
(20 SA)
.........10........20........30........40.....---...50..--......60--.--.----......70--.........80........90........100.......--110.--..----.--..--.120.......130.......140.....-..150...-.-.--..160-........170.......180.......190.......200-...--..--...210---...---......220.......230.--......240------.------------.------.--.-.--.--.250--..--..-----...260.......270.-.----..--.....----280.-.--..---------.--------...290-.--.--......300.......310----------.----..-..-..--.320......-.330-..-.----.---.----------..-------340----...--------------.....-.350.-.-.....---.360.......-370..--.----.....380....----..---.390-.........400.-.-..-...410--.-----..--.-------.---.------.----.---420.......430.----------.----------.----...----.440----.---..-----------.-----------.--------------------.-----------.450----...-.....460.......-----470.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
R
E
I
S
R
Q
T
F
L
RGA
A
G
A
L
A
A
G
A
V
FGSVRATADPAA
S
G
W
E
A
L
S
S
ALG---GKVLQPD--DGPQ
F
A
T
A
--
K
--
Q
----
V
FNTNYN---GY
T
P
A
V
I
VTPTS
Q
L
D
V
Q
K
A
M
A
F
AAANN
L
K
V
APRGGGH
S
Y
--
V
GAS--TA----N--
G
A
--
M
V
L
D
L
R
QLPGDINYDATTG
R
V
T
V
TPA
T
G
L
-
Y
A
M
H
Q
V
L
A
-A-A--GRGI--PTGTCPTVGVAGHALGGGLGANSR
H
A
G
L
L
C
D
QLTS
A
S
V
V
L--PSG--
Q
A
--
V
TAS-----ATD---HP
D
L
F
W
A
L
RGGGGGNF
G
V
T
T
--
S
L
T
F
A
TFPS------G------------D------
L
--
D
-
V
--
V
--NLNF--
P
P
--
Q
S
-----
F
A
Q
V
L
V
G
W
Q
N
W
L
R
T--A-D----RG--
S
W
A
LA----D-AT-V--DP---------L--------GTH
C
R
--
I
--
L
--
A
TCPAGSG
G
S
V
A
A
A
I
V
S
A
-----------V----GT-QP-TG--TENHT
F
N
Y
L
D
-
L
V
R
Y
-
L
A
-V----G---N----------LN-------P------SPL--------------GYVGG-SD
V
-
F
-
T
-
T
IT
P
A
---
T
A
Q
G
I
A
S
A
V
D
A
-F-PRG--A----
G
R
M
L
A
I
M
H
A
LD
G
----
A
L
---AT---VSPGATAFPWR
R
Q
-
S
-
A
L
-
V
Q
W
Y
V
---E-----TS--G-------S---
P
------
S
----
E
---
A
T
S
W
L
N
T
A
H
Q
A
V
R
A----------Y----------S----VGG----
Y
V
N
Y
----
L
---EV-----------N-----------Q--------------------
P
-----------
P
A
R
-----YFG-P
N
L
S
R
L
S
A
V
R
QKYDP-----
S
R
V
M
FSGLNF
24
PsiBlast_CBE
85.62
31%
-80
- C2 -
4XLO
1
?
D:
[7-453]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
W
L
S
R
K
Y
G
L
S
I
D
N
L
T
S
V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
A
--
M
S
C
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
-----------
L
----
H
A
G
K
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
Y
-
S
F
-
P
----
G
---
A
----------
V
V
-------
P
------
D
R
I
YTKS----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
DAR
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
4
PsiBlast_PDB
84.50
31%
-79
- C2 -
4XLO
1
?
A:
[7-453]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
W
L
S
R
K
Y
G
L
S
I
D
N
L
T
S
V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
A
--
M
S
C
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
-----------
L
----
H
A
G
K
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
Y
-
S
F
-
P
----
G
---
A
----------
V
V
-------
P
------
D
R
I
Y
T
K
S
----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
D
A
R
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
21
PsiBlast_CBE
84.46
31%
-78
- C2 -
3W8Z
2
?
B:
[11-457]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
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H
--
M
L
A
T
--
P
A
G
V
V
S
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T
G
L
G
G
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G
G
G
F
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L
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N
L
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E
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V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
A
--
M
S
C
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
-----------
L
----
H
A
G
K
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
Y
-
S
F
-
P
----
G
---
A
----------
V
V
-------
P
------
D
R
I
YTKS----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
DAR
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
25
PsiBlast_CBE
84.18
31%
-79
- C2 -
4XLO
1
?
C:
[7-453]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
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L
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I
D
N
L
T
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V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
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F
D
L
H
R
V
------
G
------------
P
------
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--
R
-
F
--
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S
T
Y
Y
--
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L
--
D
E
-----
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P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
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--
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S
C
W
I
G
D
P
H
E
G
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I
-----------
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----
H
A
G
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--
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----
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---
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----------
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V
-------
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------
D
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I
YTKS----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
DAR
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
23
PsiBlast_CBE
84.11
31%
-79
- C2 -
3W8W
1
?
B:
[11-457]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
W
L
S
R
K
Y
G
L
S
I
D
N
L
T
S
V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
A
--
M
S
C
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
-----------
L
----
H
A
G
K
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
Y
-
S
F
-
P
----
G
---
A
----------
V
V
-------
P
------
D
R
I
YTKS----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
DAR
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
22
PsiBlast_CBE
83.52
31%
-79
- C2 -
3W8X
3
?
B:
[11-457]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
W
L
S
R
K
Y
G
L
S
I
D
N
L
T
S
V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
A
--
M
S
C
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
-----------
L
----
H
A
G
K
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
Y
-
S
F
-
P
----
G
---
A
----------
V
V
-------
P
------
D
R
I
YTKS----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
DAR
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
2
PsiBlast_PDB
83.39
31%
-79
- C2 -
3W8X
2
?
A:
[11-457]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
W
L
S
R
K
Y
G
L
S
I
D
N
L
T
S
V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
A
--
M
S
C
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
-----------
L
----
H
A
G
K
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
Y
-
S
F
-
P
----
G
---
A
----------
V
V
-------
P
------
D
R
I
Y
T
K
S
----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
D
A
R
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
26
PsiBlast_CBE
83.23
31%
-80
- C2 -
4XLO
1
?
B:
[7-453]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
W
L
S
R
K
Y
G
L
S
I
D
N
L
T
S
V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
A
--
M
S
C
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
-----------
L
----
H
A
G
K
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
Y
-
S
F
-
P
----
G
---
A
----------
V
V
-------
P
------
D
R
I
Y
T
K
S
----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
D
A
R
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
1
PsiBlast_PDB
83.17
31%
-78
* C2 *
3W8W
1
?
A:
[11-457]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
W
L
S
R
K
Y
G
L
S
I
D
N
L
T
S
V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
A
--
M
S
C
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
-----------
L
----
H
A
G
K
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
Y
-
S
F
-
P
----
G
---
A
----------
V
V
-------
P
------
D
R
I
Y
T
K
S
----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
D
A
R
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
3
PsiBlast_PDB
82.87
31%
-79
- C2 -
3W8Z
2
?
A:
[11-457]
-------------------------------
D
P
A
T
L
A
--
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
A
-
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
-
S
L
M
N
S
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
W
L
S
R
K
Y
G
L
S
I
D
N
L
T
S
V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
-
G
G
G
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
P
D
----
E
L
--
T
W
A
L
Y
----
L
-
R
L
-
A
--
P
P
---------
L
PELPADMH
G
K
P
V
I
--
C
--
A
--
M
S
C
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
-----------
L
----
H
A
G
K
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
Y
-
S
F
-
P
----
G
---
A
----------
V
V
-------
P
------
D
R
I
Y
T
K
S
----------
G
Y
L
N
E
L
S
D
E
-
A
-
T
-
D
T
V
L
E
---
H
A
A
D
I
A
S
P
F
T
----------------
Q
L
E
L
L
Y
-
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
-
N
R
Q
-
S
-
P
F
-
V
T
N
L
A
---
A
-----
A
W
--
M
-------
D
---
P
------
T
----
E
D
A
R
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
NPG
E
A
-----------
D
-----------
R
--------------------
T
-----------
R
E
A
-----
Y
G
A
-
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
------
62
HHSearch
80.09
28%
-78
- C2 -
4XLO
1
?
A:
[5-458]
-------------------------------
Q
L
D
P
A
T
L
A
A
F
S
A
A
F
R
---
G
E
L
I
W
P
S
--
D
-
A
D
Y
D
E
A
--
R
--
R
----
I
W
N
G
T
I
D
----
R
R
P
A
L
I
A
R
C
T
S
T
P
D
V
V
A
A
V
S
F
A
R
K
S
G
L
L
V
A
V
R
G
G
G
H
S
M
--
A
G
H
S
--
V
C
----
D
--
G
G
--
I
V
I
D
L
S
L
M
N
S
-
I
K
V
S
R
R
L
R
R
A
R
A
Q
G
G
C
L
L
-
G
A
F
D
T
A
T
Q
-
A
-
H
--
M
L
A
T
--
P
A
G
V
V
S
H
T
G
L
G
G
L
V
L
G
G
G
F
G
W
L
S
R
K
Y
G
L
S
I
D
N
L
T
S
V
E
I
V
T
--
A
D
G
--
G
V
--
L
T
A
S
-----
D
T
E
---
N
P
D
L
F
W
A
V
R
G
G
G
-
G
N
F
G
V
V
T
--
A
F
E
F
D
L
H
R
V
------
G
------------
P
------
V
--
R
-
F
--
A
--
S
T
Y
Y
--
S
L
--
D
E
-----
G
P
Q
V
I
R
A
W
R
D
H
M
A
T
--
A
-
P
----
D
E
--
L
T
W
A
L
----
Y
-
L
R
L
A
--
P
P
LPELPADMH
G
--------
K
P
V
I
C
--
A
M
S
C
--
W
I
G
D
P
H
E
G
E
R
Q
L
E
S
I
L
H
A
-----------
G
----
K
---
P
-
H
G
--
L
T
K
A
T
L
P
Y
R
A
-
L
Q
A
--
Y
S
-
F
----
P
---
G
-----------
A
-------
V
------
V
P
D
--------------
R
I
Y
T
K
-
S
G
Y
-
L
-
N
-
E
L
S
D
E
---
A
T
D
T
V
L
E
H
A
A
D
-
I
-
A
S
--------
P
F
T
Q
L
E
L
L
Y
L
G
G
----
A
V
---
A
R
---
V
P
D
D
A
T
A
Y
P
N
R
Q
S
-
P
-
F
V
-
T
N
L
A
A
---
A
-----
W
M
D
P
T
-------
E
---
D
------
A
----
R
---
H
T
A
W
A
R
E
G
Y
R
A
L
A
G
----------
H
----------
L
----
S
G
G
----
Y
V
N
F
----
M
---
N
P
-----------
G
-----------
E
AD------------------
R
-----------
T
R
E
-----
A
Y
G
A
A
K
F
E
R
L
Q
G
V
K
A
K
Y
D
P
-----
T
N
L
F
R
L
N
Q
N
-
85
Fugue
78.33
27%
-88
- C2 -
1ZR6
7
?
A:
[3-481]
------
E
A
E
F
N
S
I
N
A
C
L
A
A
A
D
V
E
F
------
H
E
E
D
S
E
G
W
D
M
D
G
T
A
---------------------------------
F
N
L
R
V
D
----
Y
D
P
A
A
I
A
I
P
R
S
T
E
D
I
A
A
A
V
Q
C
G
L
D
A
G
V
Q
I
S
A
K
G
G
G
H
S
Y
GS
Y
G
F
G
--
G
E
----
D
--
G
H
--
L
M
L
E
L
D
R
M
Y
-
R
V
S
V
D
-
D
N
N
V
A
T
I
Q
G
G
A
R
L
G
Y
T
A
L
E
L
L
D
-
Q
-
G
--
N
R
A
L
--
S
H
G
T
C
P
A
V
G
V
G
G
H
V
L
G
G
G
Y
G
F
A
T
H
T
H
G
L
T
L
D
W
L
I
G
A
T
V
V
L
--
A
D
A
--
S
I
--
V
H
V
S
-----
E
T
E
---
N
A
D
L
F
W
A
L
R
G
G
G
G
G
-
F
A
I
V
S
--
E
F
E
F
N
T
F
E
A
------
P
------------
E
I
I
T
---
T
--
Y
-
Q
--
V
--
T
T
T
W
--
N
R
--
K
Q
-----
H
V
A
G
L
K
A
L
Q
D
W
A
Q
N
--
T
-
M
----
P
R
--
E
L
S
M
-----
R
-
L
E
-
I
--
N
A
---------
N
--------
A
L
N
W
E
--
G
--
N
--
F
F
G
N
A
K
D
L
K
K
I
L
Q
P
I
M
K
K
-----------
A
----
G
G
-
K
S
-
T
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--
S
K
L
V
E
T
D
W
Y
G
-
Q
I
N
T
-
Y
L
-
Y
----
G
---
A
----------
D
L
-------
N
------
I
T
Y
--------------
N
Y
D
V
H
-
E
Y
F
-
Y
-
A
-
N
S
L
T
A
P
RL
S
D
E
A
I
Q
A
F
V
D
Y
-
K
-
F
D
N
--
S
SVRP
G
R
G
W
W
I
Q
W
D
F
H
G
GKNS
A
L
---
A
A
---
V
S
N
D
E
T
A
Y
A
H
R
D
Q
-
L
-
W
L
-
W
Q
F
Y
D
---
S
I
YDYE
N
N
--
T
-------
S
---
P
YPESG
F
E
----
F
---
M
Q
G
F
V
A
T
I
E
D
T
L
P
E
----------
D
----------
R
----
K
G
K
----
Y
F
N
Y
ADTT
L
---
T
K
-----------
E
-----------
E
--------------------
A
-----------
Q
K
L
-----
Y
W
R
-
G
N
L
E
K
L
Q
A
I
K
A
K
Y
D
P
EDVFG
N
V
V
S
V
E
P
I
A
Y
66
HHSearch
77.45
22%
-84
- C2 -
3VTE
7
THCAS_CANSA
A:
[23-509]
-------------------------------------------------
K
L
V
Y
T
Q
H
--
D
-
Q
L
Y
M
S
I
--
L
--
N
S
T--
I
Q
N
L
R
F
I
SDT
T
P
K
P
L
V
I
V
T
P
S
N
N
S
H
I
Q
A
T
I
L
C
S
K
K
V
G
L
Q
I
R
T
R
S
G
G
H
D
A
--
E
G
M
S
--
Y
I
----
S
Q
V
P
F
--
V
V
V
D
L
R
N
M
H
S
-
I
K
I
D
V
H
S
Q
T
A
W
V
E
A
G
A
T
L
-
G
E
V
Y
Y
W
I
N
-
E
-
K
NE
N
L
S
F
--
P
G
G
Y
C
P
T
V
G
V
G
G
H
F
S
G
G
G
Y
G
A
L
M
R
N
Y
G
L
A
A
D
N
I
I
D
A
H
L
V
N
--
V
D
G
--
K
V
--
L
D
R
K
-----
S
-
M
---
G
E
D
L
F
W
A
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R
G
G
G
G
E
N
F
G
I
I
A
--
A
W
K
I
K
L
V
A
V
------
P
------------
S
------
K
--
S
T
I
--
F
--
S
V
K
K
--
N
M
E
I
H
G
-----
L
V
K
L
F
N
K
W
Q
N
I
A
Y
K
--
Y
-
D
----
K
D
--
L
V
L
M
T
----
H
F
I
T
-
K
N
I
T
--------------------
T
T
V
H
G
Y
F
S
S
I
--
F
H
G
G
V
D
S
L
V
D
L
M
N
K
S
F
P
-----------------
E
L
-
G
I
-
K
K
--
T
D
C
K
E
F
S
W
I
D
-
T
T
I
F
-
Y
S
-
G
----
V
---
V
NFKKEILLDR
S
A
-------
G
------
K
K
T
--------------
A
F
S
I
K
-
L
D
Y
-
V
K
K
-
P
I
P
E
T
---
A
M
V
K
I
L
E
K
L
Y
E
-
E
-
D
V
--------
G
A
G
M
Y
V
L
Y
P
Y
G
G
----
I
M
---
E
E
---
I
S
E
S
A
I
P
F
P
H
R
A
G
-
I
M
Y
E
-
L
W
Y
T
A
---
S
-----
W
E
K
Q
E
-------
D
---
N
------
E
----
K
---
H
I
N
W
V
R
S
V
Y
N
F
T
T
P
----------
Y
----------
V
SQNP
R
L
A
----
Y
L
N
Y
----
R
---
D
L
-----------
D
-----------
L
G
K
T
N
HASPNN
Y
T
Q
A
R
I
----
W
-----------
G
E
K
-----
Y
F
G
-
K
N
F
N
R
L
V
K
V
K
T
K
V
D
P
-----
N
N
F
F
R
N
E
Q
S
-
70
HHSearch
77.21
25%
-83
- C2 -
3RJA
12
?
A:
[13-468]
--------------------------------------------------
P
I
D
I
P
G
--
T
-
A
D
Y
E
R
D
--
V
--
E
----
P
F
N
I
R
L
P
----
Y
I
P
T
A
I
A
Q
T
Q
T
T
A
H
I
Q
S
A
V
Q
C
A
K
K
L
N
L
K
V
S
A
K
S
G
G
H
S
Y
--
A
S
F
G
FG
G
E
----
N
--
G
H
--
L
M
V
Q
L
D
R
M
I
D
V
I
S
Y
N
D
K
T
G
I
A
H
V
E
P
G
A
R
L
-
G
H
L
A
T
V
L
N
D
K
-
Y
--
G
R
A
I
--
S
H
G
T
C
P
G
V
G
I
S
G
H
F
A
H
G
G
F
G
F
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S
H
M
H
G
L
A
V
D
S
V
V
G
V
T
V
V
L
--
A
D
G
--
R
I
--
V
E
A
S
-----
A
T
E
---
N
A
D
L
F
W
G
I
K
G
A
G
-
S
N
F
G
I
V
A
--
V
W
K
L
A
T
F
P
A
------
P
------------
K
------
V
--
L
T
R
F
G
V
--
T
L
N
W
--
K
N
K
-
T
S
-----
A
L
K
G
I
E
A
V
E
D
Y
A
R
W
V-
A
-
P
----
R
E
--
V
N
F
R
I
----
G
-
D
Y
----
G
A
---------
G
--------
N
P
G
I
E
--
G
--
L
--
Y
Y
G
T
P
E
Q
W
R
A
A
F
Q
P
L
L
D
T
-----------
L
----
P
A
-
G
Y
-
V
V
--
N
P
T
T
S
L
N
W
I
E
-
S
V
L
S
-
Y
S
N
F
----
D
HVD
F
I---------
T
P
-------
Q
------
P
V
E
--------------
N
F
Y
A
K
-
S
L
T
-
L
-
K
-
S
I
K
G
D
---
A
V
K
N
F
V
D
Y
Y
F
D
-
V
-
S
N
K
VK
D
----
R
F
W
F
Y
Q
L
D
V
H
G
G
----
K
N
---
S
Q
VTK
V
T
N
A
E
T
A
Y
P
H
R
D
K
-
L
-
W
L
-
I
Q
F
Y
D
---
R
-----
Y
D
--
N
-------
N
QTY
P
------
E
TS
F
K
F
---
L
D
G
W
V
N
S
V
T
K
A
L
P
K
----------
S
----------
D
----
W
G
M
----
Y
I
N
Y
----
A
---
D
P
-----------
R
-----------
M
--------------------
D
R
D
Y
A
-------
T
K
V
-----
Y
Y
G
-
E
N
L
A
R
L
Q
K
L
K
A
K
F
D
P
-----
T
D
R
F
Y
Y
P
Q
A
-
67
HHSearch
76.65
23%
-82
- C2 -
3POP
1
?
A:
[9-498]
---------------------------------------------
P
---
P
F
T
V
G
R
E
--
D
-
P
R
Y
I
E
L
--
S
--
H
----
S
D
N
H
R
F
V
----
V
E
P
E
E
F
F
L
P
A
T
P
D
D
V
V
A
S
L
Q
K
A
V
T
E
G
R
G
V
A
C
R
S
G
G
H
C
G
--
Q
D
F
V
G-
T
P
----
R
--
R
D
--
L
V
L
D
L
H
N
L
H
A
-
I
G
P
A
A
D
G
A
G
V
R
V
G
S
G
A
T
V
-
D
Q
V
Q
K
A
L
F
-
R
R
W
--
N
A
A
L
--
P
L
G
A
C
S
A
V
G
M
G
G
L
V
A
G
G
G
Y
G
P
L
S
R
Q
L
G
L
V
V
D
H
L
H
A
V
E
V
A
V
--
V
D
E
SR
T
V
R
L
V
T
A
R
-----
A
D
D
TG
D
L
G
E
L
F
W
A
H
T
G
G
G
G
G
N
F
G
V
V
T
--
A
Y
E
F
R
S
P
E
H
LATEPV
G
------------
L
P
R
A
A
G
R
L
--
H
-
V
--
Q
--
K
V
V
F
--
P
W
--
A
M
ID
E
T
S
F
V
T
V
M
R
R
F
F
E
W
H
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R
--
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-
S
EPGS
P
E
SS
L
F
A
T
F
----
F
-
V
N
----
H
V
---------
S
--------
S
G
V
L
Q
--
L
M
V
Q
--
Q
D
A
D
V
D
P
E
G
E
I
L
A
R
F
V
A
S
-----------
L
----
T
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-
G
T
G
V
V
G
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P
R
G
G
V
M
S
W
L
T
-
G
T
R
Y
-
M
S
-
Q
----
A
---
D
C---------
G
D
-------
V
------
M
G
A
--------------
R
S
A
S
K
-
S
A
Y
-
H
-
R
A
A
P
T
D
E
---
Q
L
S
V
L
H
R
H
L
H
A
D
H
-
P
G
--------
Q
A
S
Y
V
M
F
N
S
Y
G
G
----
E
I
---
N
R
---
R
G
P
S
D
A
A
V
P
Q
R
D
S
-
V
-
V
K
-
S
S
W
F
S
---
A
-----
W
Q
D
A
E
-------
L
---
D
------
E
----
L
---
H
L
G
W
L
R
G
L
Y
E
E
F
F
A
GTGGVPVTGG
R
----------
T
----
D
G
C
----
Y
I
N
Y
----
P
---
D
A
-----------
D
-----------
L
LDPARNRSGEP---------
W
-----------
H
H
L
-----
Y
Y
K
-
D
N
Y
A
R
L
R
S
A
K
R
A
W
D
P
-----
L
N
T
F
H
H
S
M
S
-
69
HHSearch
74.97
24%
-84
- C2 -
1ZR6
7
?
A:
[8-475]
---------------------------------------
S
I
N
A
C
L
A
A
A
D
V
E
F
H
E
E
D
--
S
-
E
G
W
D
M
D
--
G
--
T
----
A
F
N
L
R
V
D
----
Y
D
P
A
A
I
A
I
P
R
S
T
E
D
I
A
A
A
V
Q
C
G
L
D
A
G
V
Q
I
S
A
K
G
G
G
H
S
Y
--
G
S
Y
G
FG
G
E
----
D
--
G
H
--
L
M
L
E
L
D
R
M
Y
R
-
V
S
V
D
D
-
N
N
V
A
T
I
Q
G
G
A
R
L
-
G
Y
T
A
L
E
L
L
-
D
Q
G
--
N
R
A
L
--
S
H
G
T
C
P
A
V
G
V
G
G
H
V
L
G
G
G
Y
G
F
A
T
H
T
H
G
L
T
L
D
W
L
I
G
A
T
V
V
L
--
A
D
A
--
S
I
--
V
H
V
S
-----
E
T
E
---
N
A
D
L
F
W
A
L
R
G
G
G
G
-
G
F
A
I
V
S
--
E
F
E
F
N
T
F
E
A
------
P
------------
E
------
I
--
I
T
T
--
Y
Q
V
T
T
T
W
--
N
R
--
K
Q
-----
H
V
A
G
L
K
A
L
Q
D
W
A
Q
N
T-
M
-
P
----
R
E
--
L
S
M
R
L
----
E
-
I
N
-
A
--
N
-------------------
A
L
N
W
E
--
G
--
N
--
F
F
G
N
A
K
D
L
K
K
I
L
Q
P
I
M
K
K
-----------
A
----
G
G
-
K
S
-
T
I
--
S
K
L
V
E
T
D
W
Y
G
-
Q
I
N
T
Y
L
Y
G
A
DLNI
T
---
Y
----------
N
Y
-------
D
------
V
H
E
--------------
Y
F
Y
A
N
-
S
L
T
-
A
-
P
-
R
L
S
D
E
---
A
I
Q
A
F
V
D
Y
K
F
D
-
N
S
S
V
R
P-
G
----
R
G
W
W
I
Q
W
D
F
H
G
G
----
K
N
SAL
A
A
---
V
S
N
D
E
T
A
Y
A
H
R
D
Q
-
L
-
W
L
-
W
Q
F
Y
D
---
S
-----
I
Y
--
D
YENNTSP
Y
---
P
------
E
----
S
---
G
F
E
F
M
Q
G
F
V
A
T
I
E
D
----------
T
LPED------
R
----
K
G
K
----
Y
F
N
Y
----
A
---
D
T
-----------
T
LT
K
--------
E
E
-------------------
A
-----------
Q
K
L
-----
Y
W
R
-
G
N
L
E
K
L
Q
A
I
K
A
K
Y
D
P
-----
E
D
V
F
G
N
V
V
S
-
71
HHSearch
74.68
23%
-80
- C2 -
2Y3S
7
?
A:
[34-524]
-------------------------------------------------
I
D
S
V
A
P
G
--
D
-
I
R
Y
E
D
L
--
R
--
R
----
G
E
N
L
R
F
V
----
G
D
P
E
E
I
H
L
V
G
S
A
A
E
I
E
Q
V
L
S
R
A
V
R
S
G
K
R
V
A
V
R
S
G
G
H
C
Y
--
E
D
F
V
--
A
N
S---
D
--
V
R
--
V
V
M
D
M
S
R
L
S
A
-
V
G
F
D
E
E
R
G
A
F
A
V
E
A
G
A
T
L
-
G
A
V
Y
K
T
L
F
-
R
V
W
--
G
V
T
L
--
P
G
G
A
C
P
D
V
G
A
G
G
H
I
L
G
G
G
Y
G
P
L
S
R
M
H
G
S
I
V
D
Y
L
H
A
V
E
V
V
V
V
D
A
S
G
--
D
A
--
R
T
V
I
A
TREP
S
D
P
---
N
H
D
L
W
W
A
H
T
G
G
G
G
G
N
F
G
V
V
V
--
R
Y
W
L
R
T
A
E
A
------
D
VPPEPGRL
L
P
R
P
P
------
A
E
V
L
-
L
--
N
--
T
T
V
W
--
P
W
--
E
G
LD
E
A
A
F
A
R
L
V
R
N
H
G
R
W
F
E
Q
N
S
G
-
P
----
D
S
--
P
W
C
D
L
Y
S
V
L
A
-
L
T
-
R
--
S
Q
S--------
G
--------
A
L
A
M
T
--
T
--
Q
--
L
D
A
T
G
P
D
A
E
K
R
L
E
T
Y
L
A
A
-----------
V
S
EGV
G
V
-
Q
P
--
H
--
S
D
T
R
R
L
P
W
L
H
-
S
T
R
W
-
P
G
-
I
----
A
---
G
----------
D
G
-------
D
------
M
T
G
--------------
R
A
K
I
K
-
A
A
Y
A
R
-
R
-
S
F
D
D
R
---
Q
I
G
T
L
Y
T
R
L
T
S
-
T
-
D
Y
D
--
N
----
P
A
G
V
V
A
L
I
A
Y
G
G
----
K
V
---
N
A
---
V
P
A
D
R
T
A
V
A
Q
R
D
S
-
I
-
L
K
-
I
V
Y
V
T
---
T
-----
W
E
DP
A
-------
Q
---
D
------
P
----
V
---
H
V
R
W
I
R
E
L
Y
R
D
V
Y
A
----------
D
TGGVPVPGGA
A
----
D
G
A
----
Y
V
N
Y
----
P
---
D
V
-----------
D
-----------
L
--------------------
A
DEEWNTSGVP
W
S
E
L
-----
Y
Y
K
-
D
A
Y
P
R
L
Q
A
V
K
A
R
W
D
P
-----
R
N
V
F
R
H
A
L
S
-
72
HHSearch
71.90
21%
-85
- C2 -
3FW9
5
RETO_ESCCA
A:
[20-490]
------------------------------------------------------
D
S
--
D
-
S
D
F
N
R
F
--
L
H
L
S
IQNP
L
F
Q
N
S
L
I
----
S
K
P
S
A
I
I
L
P
G
S
K
E
E
L
S
N
T
I
R
C
I
R
K
G
S
W
T
I
R
L
R
S
G
G
H
S
Y
--
E
G
L
S
--
Y
T
----
S
D
T
P
F
--
I
L
I
D
L
M
N
L
N
R
-
V
S
I
D
L
E
S
E
T
A
W
V
E
S
G
S
T
L
-
G
E
L
Y
Y
A
I
T
-
E
-
S
SS
K
L
G
F
--
T
A
G
W
C
P
T
V
G
T
G
G
H
I
S
G
G
G
F
G
M
M
S
R
K
Y
G
L
A
A
D
N
V
V
D
A
I
L
I
D
--
A
N
G
--
A
I
--
L
D
R
Q
-----
A
-
M
---
G
E
D
V
F
W
A
I
R
G
G
G
G
G
V
W
G
A
I
Y
--
A
W
K
I
K
L
L
P
V
------
P
------------
E
------
K
--
V
T
V
--
F
--
R
V
T
K
N
V
A
I
--
D
E
-----
A
T
S
L
L
H
K
W
Q
F
V
A
E
E
--
L
-
E
----
E
D
--
F
T
L
S
V
----
L
-
G
G
-
A
--
D
E
---------
K
--------
Q
V
W
L
T
M
L
G
--
F
--
H
F
G
L
K
T
V
A
K
S
T
F
D
L
L
F
P
E
-----------------
L
-
G
L
-
V
E
--
E
D
Y
L
E
M
S
W
G
E
-
S
F
A
Y
-
L
A
-
G
----
L
---
E
T
V
S
-------
Q
L
-------
N
NRFLKF
D
E
R
--------------
A
F
K
T
K
-
V
D
L
T
K
-
E
-
P
L
P
S
K
---
A
F
Y
G
L
L
E
R
L
S
K
-
E
-----------
P
N
G
F
I
A
L
N
G
F
G
G
----
Q
M
---
S
K
---
I
S
S
D
F
T
P
F
P
H
R
S
G
-
T
-
R
L
M
V
E
Y
I
V
---
A
-----
W
N
--
Q
SEQK---
K
---
K
------
T
----
E
---
F
L
D
W
L
E
K
V
Y
E
F
M
K
P
----------
F
----------
V
SKNP
R
L
G
----
Y
V
N
H
----
I
---
D
L
-----------
D
-----------
L
GGIDWGN
K
T
V
V
N
N
AIEISRS
W
-----------
G
E
S
-----
Y
F
L
-
S
N
Y
E
R
L
I
R
A
K
T
L
I
D
P
-----
N
N
V
F
N
H
P
Q
S
-
63
HHSearch
70.09
22%
-84
- C2 -
4UD8
5
?
A:
[52-526]
----------------------------------------------------
F
S
P
D
QN
A
-
T
L
F
K
E
E
L
E
S
--
T
----
A
Q
N
L
R
Y
L
TPS
N
P
K
P
V
F
I
F
E
P
L
Y
E
T
H
V
Q
A
A
V
V
C
A
K
K
L
Q
L
H
L
R
L
R
S
G
G
H
D
Y
--
E
G
L
S
--
F
V
AEDE
T
--
P
F
--
V
I
V
D
L
S
K
L
R
Q
-
V
D
V
D
L
D
S
N
S
A
W
A
H
A
G
A
T
I
-
G
E
V
Y
Y
R
I
Q
-
E
-
K
SQ
T
H
G
F
--
P
A
G
L
C
S
S
L
G
I
G
G
H
L
V
G
G
A
Y
G
S
M
M
R
K
F
G
L
G
A
D
N
V
L
D
A
R
I
V
D
--
A
N
G
--
Q
I
--
L
D
R
A
-----
A
-
M
---
G
E
D
V
F
W
A
I
R
G
G
G
G
G
S
F
G
V
I
L
--
A
W
K
I
K
L
V
P
V
------
P
------------
A
------
T
V
-
T
-
V
--
F
--
T
V
T
K
--
T
L
E-
Q
D
-----
G
T
K
V
L
Y
K
W
E
Q
I
A
D
K
--
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LGTNEGETD
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-
10
PsiBlast_PDB
69.58
24%
-82
- C2 -
3VTE
6
THCAS_CANSA
A:
[54-501]
-----------------------------------------------------------------------------------------
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