@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0066c: (2016-04-19 )
MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRARISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYAPDSDMTTAVMRPSKTFNAALEAVQG
Atome Classification :
(20 SA)
-------------------------------------.........10........20........30........40........50..-......60........70........80.......----.90........100.---......---------------110.......120--------.......130.....-------..140.......150.....-------..160.....-..170.......180.......190.-......200.......210--.........220.......230.......240.-......250.......260.......270-------------......--...280.......290.......300.......310.......320.......------330.......340.......350.......360------.......370----------.......380.......390......------.400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.------.--------.-....510.--......520.......530.......540.......550.......560.......570.--...----.----..580.......590.......600.......610.......---620.......630.......640.......650.......---------660.......670.......680.......690.......700.......710.......720.......730.......740...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------MSAEQ
P
T
I
I
Y
T
LTDEA
P
L
L
A
T
Y
A
F
L
P
I
V
R
A
FAEPA
G
I
K
I
EA
S
D
I
S
V
A
A
R
I
L
A
E-F
P
D
Y
L
T
E
EQRV
P
D
N
L
A
E
L
G
R
LTQLPDT
N
I
I
KLPNI----S
A
S
V
P
Q
L
V
A
A
I
K
E
L
Q---DKGYAV---------------PDYPADPKT
D
Q
E
K
--------
A
I
K
E
R
Y
A
R
C
L
G
S
A
V
N
-------
P
V
L
RQGNSDRR
A
P
K
A
V
K
E
Y
A
-------
R
KHPHSMGEW-SMASR
T
H
V
A
H
MRHGDFYAGEKSM
T
L
D
-
R
A
R
N
V
R
M
E
L
L
AKSG
K
T
I
----
V
L
KPEVPLDD
G
D
V
I
D
S
M
F
M
S
K
K
A
L
C
D
F
Y
E
E
Q
M
Q
-
D
A
F
ETG
V
M
F
S
L
H
V
K
A
T
M
M
KVSH
P
I
V
FG---------------
H
A
V
R
I
F
--
Y
K
D
A
F
A
K
H
Q
E
L
F
D
D
LGVNVNN
G
L
S
D
L
Y
S
K
I
E
SLP
A
S
Q
R
D
E
I
I
E
D
L
H
R
C
H
EHRP------E
L
A
M
VDSARGISNFHSPS
D
V
I
VDASM
P
A
M
I
RAG------
G
K
M
YGADGKL----------KDTKAVN
P
E
S
T
F
S
R
I
Y
Q
E
I
I
N
F
C
KTN------GQFDPTTMGTVPN
V
G
L
M
A
Q
Q
A
E
EYGSHDK
T
F
EIPEDGV
A
N
I
V
DVATG
E
V
L
L
TENVEAG
D
I
W
R
M
C
IVKDA
P
I
R
D
W
V
K
L
A
V
T
R
A
RISG
M
P
V
L
F
W
LDPYRP
H
E
N
E
L
I
K
------
K
--------
V
-
K
T
Y
L
K
DHD--TEG
L
D
I
Q
I
M
S
Q
V
R
S
M
R
Y
T
C
E
R
L
V
R
G
L
D
T
I
A
A
T
G
N
I
L
R
D
Y
L
T
D
L
F
P
I
L
ELGTSA
K
M
L
S
V
V
P
--LMA----G----GGMYETGAGGSA
P
K
H
V
K
Q
L
V
E
ENHL
R
W
D
S
L
G
E
F
L
A
LGAGFED---IGIKTG
N
E
R
A
K
L
L
G
K
T
L
D
A
A
I
G
K
L
LDNDKSPSRKTGELDN---------RG
S
Q
F
Y
L
A
M
Y
W
A
Q
E
L
AAQT
D
D
Q
Q
L
A
E
H
F
A
S
L
A
D
V
LTKNE
D
V
I
V
R
E
L
T
E
VQGEPVDIGGYYAPDSDM
T
T
A
VMRPS
K
T
F
N
A
A
L
E
AVQG
39
Fugue
99.04
61%
-77
- C6 -
1ITW
2
IDH_AZOVI
A:
[2-741]
----------------------------------------
S
T
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
A
P
L
A
-
18
HHSearch
97.45
61%
-77
- C6 -
1ITW
2
IDH_AZOVI
A:
[2-740]
----------------------------------------
S
T
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
E
-
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
A
P
L
--
1
PsiBlast_PDB
96.94
61%
-77
- C6 -
1ITW
2
IDH_AZOVI
A:
[4-737]
------------------------------------------
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
-----
14
PsiBlast_CBE
96.75
61%
-78
- C6 -
1ITW
2
IDH_AZOVI
D:
[4-737]
------------------------------------------
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
-----
15
PsiBlast_CBE
96.33
61%
-77
- C6 -
1ITW
2
IDH_AZOVI
C:
[4-737]
------------------------------------------
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
-----
16
PsiBlast_CBE
96.07
61%
-76
- C6 -
1ITW
3
IDH_AZOVI
B:
[4-737]
------------------------------------------
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
-----
19
HHSearch
95.04
58%
-79
- C6 -
2B0T
1
IDH_CORGL
A:
[2-736]
------------------------------------------
A
K
I
I
W
T
R
T
D
E
A
P
L
L
A
T
Y
S
L
K
P
V
V
E
A
F
A
A
T
A
G
I
E
V
E
T
R
D
I
S
L
A
G
R
I
L
A
Q
-
F
P
E
R
L
T
E
D
Q
K
V
G
N
A
L
A
E
L
G
E
L
A
K
T
P
E
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
D
Q
G
Y
D
I
---------------
P
E
L
P
D
N
A
T
T
D
E
E
K
--------
D
I
L
A
R
Y
N
A
V
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
I
A
V
K
N
F
V
-------
K
K
F
P
H
R
M
G
E
W
-
S
A
D
S
K
T
N
V
A
T
M
D
A
N
D
F
R
H
N
E
K
S
I
I
L
D
-
A
A
D
E
V
Q
I
K
H
I
A
A
D
G
T
E
T
----
I
L
K
D
S
L
K
L
L
E
G
E
V
L
D
G
T
V
L
S
A
K
A
L
D
A
F
L
L
E
Q
V
A
-
R
A
K
A
E
G
I
L
F
S
A
H
L
K
A
T
M
M
K
V
S
D
P
I
I
F
G
---------------
H
V
V
R
A
Y
--
F
A
D
V
F
A
Q
Y
G
E
Q
L
L
A
A
G
L
N
G
E
N
G
L
A
A
I
L
S
G
L
E
S
L
D
--
N
G
E
E
I
K
A
A
F
E
K
G
L
E
D
G
P
------
D
L
A
M
V
N
S
A
R
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
T
S
------
G
H
M
W
N
K
D
D
Q
E
----------
Q
D
T
L
A
I
I
P
D
S
S
Y
A
G
V
Y
Q
T
V
I
E
D
C
R
K
N
------
G
A
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
R
I
E
A
D
G
V
V
Q
V
V
S
S
-
N
G
D
V
L
I
E
H
D
V
E
A
N
D
I
W
R
A
C
Q
V
K
D
A
P
I
Q
D
W
V
K
L
A
V
T
R
S
R
L
S
G
M
P
A
V
F
W
L
D
P
E
R
A
H
D
R
N
L
A
S
------
L
--------
V
-
E
K
Y
L
A
D
H
D
--
T
E
G
L
D
I
Q
I
L
S
P
V
E
A
T
Q
L
S
I
D
R
I
R
R
G
E
D
T
I
S
V
T
G
N
V
L
R
D
Y
N
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
--
L
M
A
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
V
Q
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
A
E
S
F
R
H
---
E
L
N
N
N
G
N
T
K
A
G
V
L
A
D
A
L
D
K
A
T
E
K
L
L
N
E
E
K
S
P
S
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
W
L
T
K
F
W
A
D
E
L
A
A
Q
T
E
D
A
D
L
A
A
T
F
A
P
V
A
E
A
L
N
T
G
A
A
D
I
D
A
A
L
L
A
V
Q
G
G
A
T
D
L
G
G
Y
Y
S
P
N
E
E
K
L
T
N
I
M
R
P
V
A
Q
F
N
E
I
V
D
A
L
--
3
PsiBlast_PDB
94.52
57%
-79
- C6 -
2B0T
1
IDH_CORGL
A:
[4-736]
--------------------------------------------
I
I
W
T
R
T
D
E
A
P
L
L
A
T
Y
S
L
K
P
V
V
E
A
F
A
A
T
A
G
I
E
V
E
T
R
D
I
S
L
A
G
R
I
L
A
Q
-
F
P
E
R
L
T
E
D
Q
K
V
G
N
A
L
A
E
L
G
E
L
A
K
T
P
E
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
D
Q
G
Y
D
I
---------------
P
E
L
P
D
N
A
T
T
D
E
E
K
--------
D
I
L
A
R
Y
N
A
V
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
I
A
V
K
N
F
V
-------
K
K
F
P
H
R
M
G
E
W
-
S
A
D
S
K
T
N
V
A
T
M
D
A
N
D
F
R
H
N
E
K
S
I
I
L
D
-
A
A
D
E
V
Q
I
K
H
I
A
A
D
G
T
E
T
----
I
L
K
D
S
L
K
L
L
E
G
E
V
L
D
G
T
V
L
S
A
K
A
L
D
A
F
L
L
E
Q
V
A
-
R
A
K
A
E
G
I
L
F
S
A
H
L
K
A
T
M
M
K
V
S
D
P
I
I
F
G
---------------
H
V
V
R
A
Y
--
F
A
D
V
F
A
Q
Y
G
E
Q
L
L
A
A
G
L
N
G
E
N
G
L
A
A
I
L
S
G
L
E
S
L
--
D
N
G
E
E
I
K
A
A
F
E
K
G
L
E
D
G
P
------
D
L
A
M
V
N
S
A
R
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
T
S
------
G
H
M
W
N
K
D
D
Q
E
----------
Q
D
T
L
A
I
I
P
D
S
S
Y
A
G
V
Y
Q
T
V
I
E
D
C
R
K
N
------
G
A
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
R
I
E
A
D
G
V
V
Q
V
V
S
-
S
N
G
D
V
L
I
E
H
D
V
E
A
N
D
I
W
R
A
C
Q
V
K
D
A
P
I
Q
D
W
V
K
L
A
V
T
R
S
R
L
S
G
M
P
A
V
F
W
L
D
P
E
R
A
H
D
R
N
L
A
S
------
L
--------
V
-
E
K
Y
L
A
D
H
D
--
T
E
G
L
D
I
Q
I
L
S
P
V
E
A
T
Q
L
S
I
D
R
I
R
R
G
E
D
T
I
S
V
T
G
N
V
L
R
D
Y
N
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
--
L
M
A
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
V
Q
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
A
E
S
F
R
H
---
E
L
N
N
N
G
N
T
K
A
G
V
L
A
D
A
L
D
K
A
T
E
K
L
L
N
E
E
K
S
P
S
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
W
L
T
K
F
W
A
D
E
L
A
A
Q
T
E
D
A
D
L
A
A
T
F
A
P
V
A
E
A
L
N
T
G
A
A
D
I
D
A
A
L
L
A
V
Q
G
G
A
T
D
L
G
G
Y
Y
S
P
N
E
E
K
L
T
N
I
M
R
P
V
A
Q
F
N
E
I
V
D
A
L
--
17
PsiBlast_CBE
94.39
57%
-82
- C6 -
3MBC
1
IDH_CORGL
B:
[4-736]
--------------------------------------------
I
I
W
T
R
T
D
E
A
P
L
L
A
T
Y
S
L
K
P
V
V
E
A
F
A
A
T
A
G
I
E
V
E
T
R
D
I
S
L
A
G
R
I
L
A
Q
-
F
P
E
R
L
T
E
D
Q
K
V
G
N
A
L
A
E
L
G
E
L
A
K
T
P
E
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
D
Q
G
Y
D
I
---------------
P
E
L
P
D
N
A
T
T
D
E
E
K
--------
D
I
L
A
R
Y
N
A
V
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
I
A
V
K
N
F
V
-------
K
K
F
P
H
R
M
G
E
W
-
S
A
D
S
K
T
N
V
A
T
M
D
A
N
D
F
R
H
N
E
K
S
I
I
L
D
-
A
A
D
E
V
Q
I
K
H
I
A
A
D
G
T
E
T
----
I
L
K
D
S
L
K
L
L
E
G
E
V
L
D
G
T
V
L
S
A
K
A
L
D
A
F
L
L
E
Q
V
A
-
R
A
K
A
E
G
I
L
F
S
A
H
L
K
A
T
M
M
K
V
S
D
P
I
I
F
G
---------------
H
V
V
R
A
Y
--
F
A
D
V
F
A
Q
Y
G
E
Q
L
L
A
A
G
L
N
G
E
N
G
L
A
A
I
L
S
G
L
E
S
L
--
D
N
G
E
E
I
K
A
A
F
E
K
G
L
E
D
G
P
------
D
L
A
M
V
N
S
A
R
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
T
S
------
G
H
M
W
N
K
D
D
Q
E
----------
Q
D
T
L
A
I
I
P
D
S
S
Y
A
G
V
Y
Q
T
V
I
E
D
C
R
K
N
------
G
A
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
R
I
E
A
D
G
V
V
Q
V
V
S
-
S
N
G
D
V
L
I
E
H
D
V
E
A
N
D
I
W
R
A
C
Q
V
K
D
A
P
I
Q
D
W
V
K
L
A
V
T
R
S
R
L
S
G
M
P
A
V
F
W
L
D
P
E
R
A
H
D
R
N
L
A
S
------
L
--------
V
-
E
K
Y
L
A
D
H
D
--
T
E
G
L
D
I
Q
I
L
S
P
V
E
A
T
Q
L
S
I
D
R
I
R
R
G
E
D
T
I
S
V
T
G
N
V
L
R
D
Y
N
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
--
L
M
A
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
V
Q
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
A
E
S
F
R
H
---
E
L
N
N
N
G
N
T
K
A
G
V
L
A
D
A
L
D
K
A
T
E
K
L
L
N
E
E
K
S
P
S
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
W
L
T
K
F
W
A
D
E
L
A
A
Q
T
E
D
A
D
L
A
A
T
F
A
P
V
A
E
A
L
N
T
G
A
A
D
I
D
A
A
L
L
A
V
Q
G
G
A
T
D
L
G
G
Y
Y
S
P
N
E
E
K
L
T
N
I
M
R
P
V
A
Q
F
N
E
I
V
D
A
L
--
4
PsiBlast_PDB
94.11
57%
-81
- C6 -
3MBC
2
IDH_CORGL
A:
[4-736]
--------------------------------------------
I
I
W
T
R
T
D
E
A
P
L
L
A
T
Y
S
L
K
P
V
V
E
A
F
A
A
T
A
G
I
E
V
E
T
R
D
I
S
L
A
G
R
I
L
A
Q
-
F
P
E
R
L
T
E
D
Q
K
V
G
N
A
L
A
E
L
G
E
L
A
K
T
P
E
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
D
Q
G
Y
D
I
---------------
P
E
L
P
D
N
A
T
T
D
E
E
K
--------
D
I
L
A
R
Y
N
A
V
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
I
A
V
K
N
F
V
-------
K
K
F
P
H
R
M
G
E
W
-
S
A
D
S
K
T
N
V
A
T
M
D
A
N
D
F
R
H
N
E
K
S
I
I
L
D
-
A
A
D
E
V
Q
I
K
H
I
A
A
D
G
T
E
T
----
I
L
K
D
S
L
K
L
L
E
G
E
V
L
D
G
T
V
L
S
A
K
A
L
D
A
F
L
L
E
Q
V
A
-
R
A
K
A
E
G
I
L
F
S
A
H
L
K
A
T
M
M
K
V
S
D
P
I
I
F
G
---------------
H
V
V
R
A
Y
--
F
A
D
V
F
A
Q
Y
G
E
Q
L
L
A
A
G
L
N
G
E
N
G
L
A
A
I
L
S
G
L
E
S
L
--
D
N
G
E
E
I
K
A
A
F
E
K
G
L
E
D
G
P
------
D
L
A
M
V
N
S
A
R
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
T
S
------
G
H
M
W
N
K
D
D
Q
E
----------
Q
D
T
L
A
I
I
P
D
S
S
Y
A
G
V
Y
Q
T
V
I
E
D
C
R
K
N
------
G
A
F
D
P
T
T
M
G
T
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
R
I
E
A
D
G
V
V
Q
V
V
S
-
S
N
G
D
V
L
I
E
H
D
V
E
A
N
D
I
W
R
A
C
Q
V
K
D
A
P
I
Q
D
W
V
K
L
A
V
T
R
S
R
L
S
G
M
P
A
V
F
W
L
D
P
E
R
A
H
D
R
N
L
A
S
------
L
--------
V
-
E
K
Y
L
A
D
H
D
--
T
E
G
L
D
I
Q
I
L
S
P
V
E
A
T
Q
L
S
I
D
R
I
R
R
G
E
D
T
I
S
V
T
G
N
V
L
R
D
Y
N
T
D
L
F
P
I
L
E
L
G
T
S
A
K
M
L
S
V
V
P
--
L
M
A
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
V
Q
E
E
N
H
L
R
W
D
S
L
G
E
F
L
A
L
A
E
S
F
R
H
---
E
L
N
N
N
G
N
T
K
A
G
V
L
A
D
A
L
D
K
A
T
E
K
L
L
N
E
E
K
S
P
S
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
W
L
T
K
F
W
A
D
E
L
A
A
Q
T
E
D
A
D
L
A
A
T
F
A
P
V
A
E
A
L
N
T
G
A
A
D
I
D
A
A
L
L
A
V
Q
G
G
A
T
D
L
G
G
Y
Y
S
P
N
E
E
K
L
T
N
I
M
R
P
V
A
Q
F
N
E
I
V
D
A
L
--
2
PsiBlast_PDB
93.78
61%
-72
- C6 -
1J1W
1
IDH_AZOVI
A:
[4-737]
------------------------------------------
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
-----
13
PsiBlast_CBE
93.65
61%
-72
- C6 -
1J1W
1
IDH_AZOVI
B:
[4-737]
------------------------------------------
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
-----
11
PsiBlast_CBE
93.65
61%
-72
- C6 -
1J1W
1
IDH_AZOVI
D:
[4-737]
------------------------------------------
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
-----
12
PsiBlast_CBE
93.46
61%
-72
- C6 -
1J1W
1
IDH_AZOVI
C:
[4-737]
------------------------------------------
P
K
I
I
Y
T
L
T
D
E
A
P
A
L
A
T
Y
S
L
L
P
I
I
K
A
F
T
G
S
S
G
I
A
V
E
T
R
D
I
S
L
A
G
R
L
I
A
T
-
F
P
E
Y
L
T
D
T
Q
K
I
S
D
D
L
A
E
L
G
K
L
A
T
T
P
D
A
N
I
I
K
L
P
N
I
----
S
A
S
V
P
Q
L
K
A
A
I
K
E
L
Q
---
Q
Q
G
Y
K
L
---------------
P
D
Y
P
E
E
P
K
T
D
T
E
K
--------
D
V
K
A
R
Y
D
K
I
K
G
S
A
V
N
-------
P
V
L
R
E
G
N
S
D
R
R
A
P
L
S
V
K
N
Y
A
-------
R
K
H
P
H
K
M
G
A
W
-
S
A
D
S
K
S
H
V
A
H
M
D
N
G
D
F
Y
G
S
E
K
A
A
L
I
G
-
A
P
G
S
V
K
I
E
L
I
A
K
D
G
S
S
T
----
V
L
K
A
K
T
S
V
Q
A
G
E
I
I
D
S
S
V
M
S
K
N
A
L
R
N
F
I
A
A
E
I
E
-
D
A
K
K
Q
G
V
L
L
S
V
H
L
K
A
T
M
M
K
V
S
D
P
I
M
F
G
---------------
Q
I
V
S
E
F
--
Y
K
D
A
L
T
K
H
A
E
V
L
K
Q
I
G
F
D
V
N
N
G
I
G
D
L
Y
A
R
I
K
T
L
P
E
A
K
Q
K
E
I
E
A
D
I
Q
A
V
Y
A
Q
R
P
------
Q
L
A
M
V
N
S
D
K
G
I
T
N
L
H
V
P
S
D
V
I
V
D
A
S
M
P
A
M
I
R
D
S
------
G
K
M
W
G
P
D
G
K
L
----------
H
D
T
K
A
V
I
P
D
R
C
Y
A
G
V
Y
Q
V
V
I
E
D
C
K
Q
H
------
G
A
F
D
P
T
T
M
G
S
V
P
N
V
G
L
M
A
Q
K
A
E
E
Y
G
S
H
D
K
T
F
Q
I
P
A
D
G
V
V
R
V
T
D
-
E
S
G
K
L
L
L
E
Q
S
V
E
A
G
D
I
W
R
M
C
Q
A
K
D
A
P
I
Q
D
W
V
K
L
A
V
N
R
A
R
A
T
N
T
P
A
V
F
W
L
D
P
A
R
A
H
D
A
Q
V
I
A
------
K
--------
V
-
E
R
Y
L
K
D
Y
D
--
T
S
G
L
D
I
R
I
L
S
P
V
E
A
T
R
F
S
L
A
R
I
R
E
G
K
D
T
I
S
V
T
G
N
V
L
R
D
Y
L
T
D
L
F
P
I
M
E
L
G
T
S
A
K
M
L
S
I
V
P
--
L
M
S
----
G
----
G
G
L
F
E
T
G
A
G
G
S
A
P
K
H
V
Q
Q
F
L
E
E
G
Y
L
R
W
D
S
L
G
E
F
L
A
L
A
A
S
L
E
H
---
L
G
N
A
Y
K
N
P
K
A
L
V
L
A
S
T
L
D
Q
A
T
G
K
I
L
D
N
N
K
S
P
A
R
K
V
G
E
I
D
N
---------
R
G
S
H
F
Y
L
A
L
Y
W
A
Q
A
L
A
A
Q
T
E
D
K
E
L
Q
A
Q
F
T
G
I
A
K
A
L
T
D
N
E
T
K
I
V
G
E
L
A
A
A
Q
G
K
P
V
D
I
A
G
Y
Y
H
P
N
T
D
L
T
S
K
A
M
R
P
S
A
T
F
N
A
A
L
-----
33
HHSearch
37.26
19%
-71
- C6 -
1W0D
-
LEU3_MYCTU
A:
[153-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
-
R
R
K
H
L
T
L
V
-----
H
K
T
N
V
L
T
------
F
A
G
G
L
W
L
R
T
V
-
D
E
V
G
E
C
Y
----
P
D
V
E
V
A
Y
Q
H
V
D
A
A
T
I
H
M
I
T
D
P
-
G
R
F
D
V
I
-
V
T
D
N
L
F
G
D
I
I
T
D
L
A
A
A
V
-
C
G
G
----
I
G
L
A
A
--
S
G
N
ID--
A
TRA
N
P
S
M
F
E
P
-
V
H
G
S
A
P
D
I
A
G
Q
----
G
I
--
A
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H
---
L
G
E
H
D
-------
A
A
A
R
V
D
R
A
V
E
A
H
L
A
T
R
G
----------------------------------------------------------------------------------------------------------
31
HHSearch
34.38
21%
-58
- C6 -
1A05
4
LEU3_ACIFR
A:
[163-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
-
R
K
Q
L
C
S
V
-----
D
K
A
N
V
L
E
------
T
T
R
L
W
R
E
V
-
V
-
T
E
V
A
R
D
Y
----
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
-
A
Q
F
D
V
L
-
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
-
T
G
S
----
I
G
M
L
P
--
S
A
S
L
G
E-
G
----
R
A
M
Y
E
P
-
I
H
G
S
A
P
D
I
A
G
Q
----
D
--
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
---
S
L
N
A
--
E
P
----
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
L
----------------------------------------------------------------------------------------------------------
44
Fugue
33.54
16%
-24
- C2 -
4ZUZ
-
?
A:
[8-864]
D
V
I
K
F
K
EPERCDY
L
Y
V
D
ENN
K
V
H
I
L
L
P
IVGGDE
I
G
L
D
N
T
C
Q
T
A
V
E
L
I
T
F
F
Y
G
S
A
H
S
G
V
T
K
Y
S
A
E
H
Q
L
S
E
Y
K
R
Q
L
E
E
D
I
K
A
I
N
S
Q
K
K
I
S
P
H
A
Y
D
D
L
L
K
E
K
I
E
R
L
Q
Q
I
E
K
Y
I
E
L
I
Q
V
L
K
K
Q
Y
D
E
Q
N
D
I
R
Q
L
R
T
G
G
I
P
Q
L
P
S
G
V
K
E
I
I
K
S
S
E
N
A
F
A
V
R
L
S
P
YDNDKFTRFDD
P
L
F
N
V
K
R
N
I
S
K
Y
D
TPSRQ
A
P
I
P
I
Y
E
G
L
G
Y
R
L
R
S
T
L
F
PEDK
T
P
T
P
I
N
K
K
S
L
R
D
K
V
K
S
T
V
L
S
H
Y
K
DEDRIDG
E
K
K
D
E
K
L
N
E
L
I
T
N
L
Q
N
E
L
V
K
E
L
V
K
S
D
P
Q
Y
S
K
L
S
L
S
K
D
P
R
G
K
E
I
N
Y
D
Y
L
V
N
S
L
M
L
V
DNDS
E
I
G
D
W
I
D
T
I
L
D
A
T
V
D
S
T
V
W
A
V
Q
A
S
S
P
F
Y
Q
G
A
K
E
I
S
S
D
R
D
A
D
K
I
S
I
R
V
Q
Y
L
L
A
E
A
N
I
Y
C
K
T
N
KLSDAN
F
G
E
F
F
D
KE
P
H
A
T
E
I
A
K
R
V
K
E
G
F
T
Q
G
A
D
I
E
P
I
I
Y
D
Y
I
N
S
N
H
A
E
L
G
L
K
-
S
P
L
T
G
K
Q
Q
Q
E
I
T
D
K
F
T
K
H
Y
N
T
I
K
ESPHFD
E
F
F
V
A
D
P
D
K
K
-
G
N
I
F
S
H
Q
G
R
I
S
C
H
F
L
D
F
F
T
R
Q
T
KGKHPL
G
D
L
A
S
H
Q
E
A
L
Q
E
GTSNRLHH
K
N
E
V
V
A
Q
G
Y
E
K
L
D
Q
F
K
K
E
V
V
K
L
L
A
E
N
K
P
K
E
L
L
D
Y
L
V
A
T
S
P
T
G
V
P
N
Y
S
M
L
S
K
E
T
Q
N
Y
I
A
Y
N
R
N
W
P
A
I
Q
K
E
L
E
K
A
T
S
I
P
--------
E
S
Q
K
Q
D
L
S
R
L
L
S
R
D
N
L
Q
H
D
N
L
S
--
A
I
T
W
S
K
Y
S
S
K
P
L
L
D
V
E
L
N
K
I
A
E
G
L
E
L
T
A
------
K
--------
I
-
Y
N
E
K
R
G
R
E
WW
F
A
G
------
S
R
N
E
A
R
K
T
Q
C
E
E
L
Q
R
V
S
K
E
I
N
T
L
L
Q
--
S
E
S
L
T
K
S
Q
V
L
E
K
V
L
N
S
I
E
T
L
D
K
I
D
R
D
I
S
A
----
E
----
S
N
W
F
Q
S
-----------
T
L
Q
K
E
V
R
L
F
R
D
Q
L
K
D
I
C
Q
L
D
K
Y
Y
F
K
S
TK
L
D
E
I
I
S
L
E
M
E
E
Q
F
Q
K
I
Q
D
P
A
V
Q
Q
I
V
R
D
L
P
S
H
C
H
N
D
E
A
I
E
F
F
K
T
L
N
P
E
E
A
A
K
V
A
S
Y
L
S
L
E
Y
-
R
E
I
N
K
S
T
D
K
K
T
L
L
E
-----
Q
D
I
P
R
L
F
K
E
V
N
T
Q
L
L
S
K
L
K
E
E
K
-
A
I
D
E
Q
V
H
E
K
L
S
Q
L
A
D
K
I
A
P
E
H
F
T
R
N
N
I
I
K
W
S
T
38
HHSearch
32.82
18%
-53
- C6 -
4XXV
2
LEU3_BURTA
A:
[173-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
R
A
K
K
L
L
S
------
V
D
K
S
N
V
L
E
T
S
Q
F
W
R
D
--------
V
M
I
D
V
S
K
E
Y
----
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
-
K
Q
F
D
-
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
-
T
G
----
S
I
G
M
L
P
--
S
A
S
L
D
KN
N
----
K
G
L
Y
E
P
-
S
H
G
S
A
P
D
I
A
G
K
----
G
I
--
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
S--
L
N
R
A
E
-------
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
Y
----------------------------------------------------------------------------------------------------------
34
HHSearch
31.97
15%
-45
- C6 -
3FLK
10
TTUC_PSEPU
A:
[162-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
T
R
R
G
V
D
R
I
L
K
Y
A
F
D
L
A
E
K
R
E
R
K
H
V
T
S
A
-----
T
K
S
N
G
M
A
------
I
S
M
P
Y
W
D
K
R
T
-
E
A
M
A
A
H
Y
----
P
H
V
S
W
D
K
Q
H
I
D
I
L
C
A
R
F
V
L
Q
P
-
E
R
F
D
V
V
-
V
A
S
N
L
F
G
D
I
L
S
D
L
-----
G
P
A
C
A
G
T
I
G
I
A
P
--
S
A
N
LN--
P
ERN
F
P
S
L
F
E
P
-
V
H
G
S
A
P
D
I
F
G
K
----
N
I
--
A
N
P
I
A
M
I
W
S
G
A
L
M
L
E
F
---
L
G
Q
G
D
--
E
R
Y
Q
R
A
H
D
D
M
L
N
A
I
E
R
V
I
A
D
G
S
V
-
T
P
D
M
G
---------------------------------------------------------------------------------------------------
28
HHSearch
30.91
16%
-56
- C6 -
2D1C
4
IDH_THET8
A:
[148-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
M
Q
T
P
S
V
A
Q
T
L
K
L
I
S
W
K
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
E
G
R
K
K
V
H
C
A
-----
T
K
S
N
I
M
K
------
L
A
E
G
T
L
K
R
-
A
F
E
Q
V
A
Q
E
Y
----
P
D
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
-
E
Q
F
E
V
I
-
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
-
I
G
----
G
L
G
F
A
P
--
S
A
N
IGN-
E
----
V
A
I
F
E
A
-
V
H
G
S
A
P
K
Y
A
G
K
----
N
V
--
I
N
P
T
A
V
L
L
S
A
V
M
M
L
R
Y
---
L
E
E
F
A
-------
T
A
D
L
I
E
N
A
L
L
Y
T
L
E
E
G
R
----------------------------------------------------------------------------------------------------------