@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0072: (2016-04-19 )
MLFAALRDMQWRKRRLVITIISTGLIFGMTLVLTGLANGFRVEARHTVDSMGVDVFVVRSGAAGPFLGSIPFPDVDLARVAAEPGVMAAAPLGSVGTIMKEGTSTRNVTVFGAPEHGPGMPRVSEGRSPSKPDEVAASSTMGRHLGDTVEVGARRLRVVGIVPNSTALAKIPNVFLTTEGLQKLAYNGQPNITSIGIIGMPRQLPEGYQTFDRVGAVNDLVRPLKVAVNSISIVAVLLWIVAVLIVGSVVYLSALERLRDFAVFKAIGTPTRSIMAGLALQALVIALLAAVVGVVLAQVLAPLFPMIVAVPVGAYLALPVAAIVIGLFASVAGLKRVVTVDPAQAFGGP
Atome Classification :
(20 SA)
----------------------------------.......---..10........20-........30........40-------........50........60......-..70..-......80......----..90-......-..-.100.-......110......--.120.......130----.......-..----140-.---.......150----.......------------160......-.-170...--....180......-.-190......-----.200.......210.....--..220..-------......230...---....240..---------...--..250.......260.......270.......280-----..--.....290.--------------------------......300.......-310--..-------...-----..----.320-----.........330.------......340........
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------
M
L
F
A
A
L
R
---
D
M
Q
W
RK
R
R
L
V
I
T
I
I-S
T
G
L
I
F
G
M
T
L
V
L
T
GLAN
G
F
R
-------
V
E
A
RHTVDSMG
V
D
V
F
V
V
RSGAAGPFL-GSIPFP-D
V
D
L
A
R
V
AAEPG
V
M
----
A
AA--PLG
S
V
G
-
T
I
-
M
KEGT-STR
N
V
T
V
F
GAPEHGP--GMPRVSEGRSPS------K
P
D
E
V
A
A
-
S
S
----
T
M
--
G
---
R
HLG
D
T
V
E
V
G----A
R
R
L
R
V
V
------------
G
IVPNS
T
A
L
-A-KIP
N
V
F
--L
T
T
E
G
L
Q
K
LAYNG-Q-PN
I
T
S
I
GII-----GMPRQLP
E
G
Y
Q
T
F
D
RV
G
A
V
--
N
D
L
-
V
R
P
-------
L
K
V
A
V
N
S
I
S
I
V
A
---
V
L
L
W
I
V
A
V
L
---------
I
V
G
--
S
V
V
Y
L
S
A
L
E
R
L
R
D
F
A
V
F
K
AIGT
P
T
R
S
I
M
A
G
L
A
L
Q
A
-----
L
V
--
I
A
L
L
A
A
V
V
G
--------------------------
V
V
L
A
Q
V
L
A
P
L
F
P
M
I
V
A-VP---V
G
-------
A
Y
L
-----
A
L
----
P
V
-------
A
A
I
V
I
G
L
F
A
S
V
AG------L
K
R
V
V
T
V-D
P
A
Q
AFGGP
24
Fugue
81.29
17%
-104
- C2 -
1G8L
9
MOEA_ECOLI
A:
[7-409]
----------------------------LMS
L
D
T
A
L
N
E
M
L
S
---
R
V
T
P
L
T
A
Q
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
----------
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
Q
P
L
P
V
A
-
G
K
S
F
A
G
-
Q
P
Y
H
G
E
W
P
A
G
T
C
I
R
I
M
TG
A
P
V
--
P
E
G
C
E
A
-
V
V
-
M
Q
E
Q
T
-
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
--
G
Q
N
I
R
R
R
G
E
D
I
S
------
A
G
A
V
V
F
P
-
A
G
----
T
R
L
T
T
---
A
E
L
P
V
I
A
S
L
G
----
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
-
G
-
D
G
Q
I
Y
D
--
T
N
R
L
A
V
H
L
M
L
E
Q
L
-
G
-
C
E
V
I
N
L
G
I
I
RDD
P
H
A
L
R
A
A
F
I
E
A
D
S
Q
A
D
V
V
I
S
S
--
G
G
V
S
V
G
E
-------
A
D
Y
T
K
T
I
L
E
E
L
G
---
E
I
A
F
W
K
L
A
I
---------
K
P
G
--
K
P
F
A
F
G
K
L
S
N
S
------
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
-----
L
V
--
Q
P
L
L
A
K
L
S
G
NTASGL
P
A
R
Q
R
V
R
T
ASRLKKTPGRLD
F
Q
R
G
V
L
Q
R
N
A
D
G
E
L
E
V
-
T
T
---
T
G
HQGSHIF
S
S
F
-----
S
L
----
G
N
-------
C
F
I
V
L
E
R
D
R
G
N
V
E
------
V
G
E
W
V
E
V
-
E
P
F
N
A
L
F
G
-
30
Fugue
72.69
17%
-64
- C8 -
4UX8
-
GFRA1_RAT
C:
[25-343]
--------------------------------DR
L
D
C
V
K
A
S
---
D
Q
C
L
K
E
---------------------
Q
S
C
S
T
K
Y
R
-------
T
L
R
Q
C
V
------------
A
G
K
E
T
N
F
S
-
L
T
S
G
L
E
-
A
K
D
E
C
R
S
A
M
E
A
L
-----------------------
K
Q
K
-
S
L
Y
N
C
R
C
K
R
G
M
K
K
E
K
--
N
C
L
R
I
Y
W
S
M
Y
Q
S
------
K
G
N
N
C
L
D
-
A
A
----
K
A
--
C
---
N
-----
L
D
D
T
----
C
K
K
Y
R
S
A
------------
Y
I
T
P
C
T
T
S
M
-
S
N
E
V
C
N
R
R
--
K
C
H
K
A
L
R
Q
F
-
F
D
K
-
V
-
P
A
K
H
S
Y
G
M
L
FCSC-
R
D
I
A
C
T
E
R
R
R
Q
T
I
V
P
V
C
S
Y
--
E
E
R
-
E
R
P
-------
N
C
L
S
L
Q
D
S
C
K
T
N
------------------------------
Y
I
C
R
S
R
L
A
D
F
--
F
T
N
C
Q
P
E
S
R
S
V
S
N
C
L
K
E
N
Y
-----
A
D
C-
L
L
A
Y
S
G
L
I
G
--------------------------
T
V
M
T
P
N
Y
V
D
S
S
S
L
S
V
A
-
P
W
CDC
S
N
-------
S
G
N
-----
D
L
----
E
D
-------
C
L
K
F
L
N
F
F
K
D
N
T
C
------
L
K
N
A
I
------
Q
A
F
G
N
G
23
Fugue
62.66
17%
-101
* C9 *
4CZB
1
NAH1_METJA
A:
[1-415]
M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
S
L
V
A
K
I
A
E
K
L
KIPD
I
P
L
L
L
L
L
G
L
I
I
G
P
F
L
Q
I
I
P
S
D
S
A
M
E
I
F
-
E
Y
A
G
P
I
G
L
I
F
I
L
L
G
G
A
F
T
M
R
ISLLKRV
I
K
T
V
V
R
L
D
T
I
T
F
L
I
T
L
L
I
S
G
F
I
F
N
M
V
-
L
N
L
P
Y
T
-----
S
P
V
G
Y
L
F
G
A
I
----
T
A
A
T
D
P
A
T
L
I
P
-
V
F
-
S
R
V
R
T
N
P
E
V
A
I
T
L
E
A
E
S
I
F
N
D
--
P
L
G
I
V
S
T
S
V
I
L
G
------
L
F
G
L
F
S
S
-
S
N
----
P
L
--
I
---
D
L
I
T
L
A
G
G
A
I
----
V
V
G
L
L
L
A
------------
K
I
Y
E
K
I
I
I
H
-
C
-
D
F
H
E
Y
V
A
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
-
D
-
D
L
L
P
S
I
C
G
Y
-----
G
F
S
-----
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
-
F
R
A
DDID
Y
K
Y
I
V
S
F
C
D
D
L
S
L
L
A
R
V
F
I
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
Y
F
I
P
G
--
L
L
V
A
L
G
S
I
F
L
A
R
P
L
G
V
F
L
G
L
I
G
S
K
H
S
F
K
E
K
L
Y
F
A
L
E
G
P
R
G
V
V
--
P
A
A
L
A
V
T
V
G
--------------------------
I
E
I
L
K
N
A
D
K
I
P
A
S
I
T
K
Y
I
T
---
P
T
-------
D
I
A
-----
G
T
----
I
I
-------
I
G
T
F
M
T
I
L
L
S
V
I
L
------
E
A
S
W
A
G
M
-
L
A
L
K
L
L
G
E
-
12
HHSearch
56.94
18%
-48
- C11 -
3FTJ
-
MACB_AGGAC
A:
[339-488]
--------------------------------------------------------------------------------------------------------------------
N
L
K
-
I
S
D
A
N
T
L
S
K
Q
S
Y
I
Q
----
S
V
T
--
P
N
T
S
S
S
-
G
I
-
L
V
V
G
N
K
S
F
T
S
A
N
L
Y
G
I
G
E
Q
Y
F
D
V
E
G
L
K
L
K
Q
G
R
L
L
T
E
D
D
V
D
Q
S
N
Q
V
V
V
L
-
D
E
S
A
K
K
A
I
--
F
ANE
N
P
L
G
K
T
V
I
F
N
----
K
R
P
F
R
V
I
------------
G
V
V
S
D
Q
-------
S
L
N
L
Y
--
S
P
Y
S
T
V
L
N
K
I
T
G
--
G
-
S
R
I
G
S
I
T
V
K
-----
I
S
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
56.46
12%
-95
* C8 *
3L09
2
?
A:
[6-255]
----------------------------SD
P
I
R
P
L
V
E
A
L
N
A
---
E
A
P
L
K
L
W
S
V
L
V
T
C
L
-
G
D
V
S
R
D
G
V
I
E
V
S
G
V
A
L
S
S
F
V
-------
E
------------------------
R
M
G
L
Q
P
Q
A
M
R
V
A
L
H
R
L
K
R
D
---------------
G
W
V
E
-
S
R
-
R
L
G
R
V
-
G
F
H
R
L
S
D
S
A
L
T
Q
T
R
A
--
V
A
G
R
I
Y
G
P
G
A
G
P
------
A
P
W
H
L
A
G
M
P
P
----
D
A
--
P
---
D
G
L
S
L
L
P
D
-------
T
L
S
A
T
P
------------
I
S
R
R
F
A
L
I
C
-
G
-
P
L
E
D
--------------
V
P
E
-
D
-
W
L
L
T
A
P
S
G
R
-----
G
L
P
V
W
V
Q
D
V
V
V
E
A
G
C
E
A
E
F
--
K
A
L
-
E
R
T
-------
L
A
------------------------------------------------------
Q
I
D
K
V
P
D
T
R
L
E
R
F
T
L
R
V
-----
L
V
--
L
H
A
W
R
R
L
I
--------------------------------
L
R
S
S
P
A
A
E
A
A
L
-
G
G
------------
A
R
A
-----
E
I
----
S
C
-------
R
A
R
V
H
Q
L
L
D
Q
L
G
S
------
V
E
P
D
-------------
6
PsiBlast_PDB
51.96
30%
-261
- C- -
2CSE
-
?
A:
[144-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
--
C
Y
V
G
V
S
A
R
Q
A
L
N
N
F
Q
K
Q
V
P
V
I
T
P
T
R
Q
T
M
Y
V
D
S
I
Q
A
-----
A
L
--
K
A
L
E
K
W
E
I
D
--------------------------
L
R
V
A
Q
T
L
L
P
-----
T
N
-
V
P
---
I
G
-------
E
-
V
-----
S
C
----
P
M
-------
Q
S
V
V
--------------------------------
7
PsiBlast_PDB
50.48
29%
-130
- C10 -
1U77
-
AMTB_ECOLI
A:
[215-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
A
G
S
A
G
T
A
N
E
I
A
A
L
A
F
V
N
-----
T
V
--
V
A
T
A
A
A
I
L
G
--------------------------
W
I
F
G
E
W
A
L
R
G
L
P
S
L
L
G
-
A
C
---
S
G
-------
A
I
A
-----
G
L
V
G
V
T
P
A
CGYIG
V
G
G
A
L
I
I
G
V
V
A
G
L
A
G
L
W
G
V
T
M
L
K
R
L
L
R
V
D
D
P
C
D
V
F
G
--
1
PsiBlast_PDB
50.39
29%
-162
- C10 -
2XQ2
1
SGLT_VIBPH
A:
[128-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
L
A
---
V
F
-
W
I
S
L
Y
I
---------
F
V
N
L
T
S
V
L
Y
L
G
G
L
------
A
L
E
T
I
L
G
I
P
L
M
Y
S
I
L
G
L
A
L
F
A
-----
L
V
--
Y
S
I
Y
G
G
-----------------------------
V
V
W
T
D
V
I
Q
V
F
F
-
L
V
L
G
-
G
F
---
M
T
-------
T
Y
M
-----
A
V
----
S
F
-------
I
G
G
T
D
G
W
F
A
G
V
S
K
------
M
----------------
8
PsiBlast_PDB
50.10
29%
-128
- C10 -
1U7C
1
AMTB_ECOLI
A:
[215-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
A
G
S
A
G
T
A
N
E
I
A
A
L
A
F
V
N
-----
T
V
--
V
A
T
A
A
A
I
L
G
--------------------------
W
I
F
G
E
W
A
L
R
G
L
P
S
L
L
G
-
A
C
---
S
G
-------
A
I
A
-----
G
L
V
G
V
T
P
A
CGYIG
V
G
G
A
L
I
I
G
V
V
A
G
L
A
G
L
W
G
V
T
M
L
K
R
L
L
R
V
D
D
P
C
D
V
F
G
--
9
PsiBlast_PDB
49.72
29%
-125
- C10 -
1U7G
4
AMTB_ECOLI
A:
[215-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
A
G
S
A
G
T
A
N
E
I
A
A
L
A
F
V
N
-----
T
V
--
V
A
T
A
A
A
I
L
G
--------------------------
W
I
F
G
E
W
A
L
R
G
L
P
S
L
L
G
-
A
C
---
S
G
-------
A
I
A
-----
G
L
V
G
V
T
P
A
CGYIG
V
G
G
A
L
I
I
G
V
V
A
G
L
A
G
L
W
G
V
T
M
L
K
R
L
L
R
V
D
D
P
C
D
V
F
G
--
13
HHSearch
49.35
16%
-25
- C11 -
3IS6
2
?
A:
[49-190]
-------------------------------------------------------------------------------------------------------------------------------
E
E
I
P
G
V
E
----
L
A
T
--
R
T
T
L
Y
G
T
S
K
M
I
L
E
D
N
-
K
T
Y
E
T
K
T
L
L
A
E
P
A
F
L
D
M
F
G
V
E
L
I
A
G
V
R
D
S
ALR---
D
N
M
T
C
L
I
-
S
E
S
L
A
R
K
M
G-
G
---
D
V
L
G
K
R
L
R
P
A
ESKS
D
R
A
I
T
I
G
------------
G
V
F
E
D
L
P
H
N
S
S
-
I
Q
A
D
M
L
--
L
P
I
T
W
M
P
A
E
S
L
N
N
W
I
G
N
D
R
Y
I
A
Y
V
R
-----
L
R
P
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
48.86
40%
-124
- C10 -
4Z3N
4
?
A:
[324-393]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
V
T
R
T
L
N
A
Y
W
A
A
V
A
-----
L
A
F
S
I
V
L
V
L
A
V
M
H
--------------------------
I
V
L
A
P
W
M
Y
P
L
F
T
R
V
V
A
-
V
S
---
D
Y
-------
A
V
L
Q
T
R
I
M
A
L
----
A
L
-------
P
F
V
A
I
S
L
L
A
S
--------------------------
3
PsiBlast_PDB
47.34
40%
-130
- C10 -
4Z3P
-
?
A:
[324-393]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
V
T
R
T
L
N
A
Y
W
A
A
V
A
-----
L
A
F
S
I
V
L
V
L
A
V
M
H
--------------------------
I
V
L
A
P
W
M
Y
P
L
F
T
R
V
V
A
-
V
S
---
D
Y
-------
A
V
L
Q
T
R
I
M
A
L
----
A
L
-------
P
F
V
A
I
S
L
L
A
S
--------------------------
11
HHSearch
42.43
13%
32
- C11 -
5F9Q
-
?
A:
[40-186]
--------------------------------------------------------------------------------------------------------------------
S
F
T
-
E
E
D
I
N
G
L
K
G
V
D
G
V
K
----
Q
V
V
--
A
S
A
V
K
S
-
M
T
-
A
R
Y
H
E
-
E
D
T
D
I
T
L
N
G
I
N
S
G
Y
M
D
V
K
K
L
D
V
Q
D
G
R
T
F
T
D
N
D
F
L
S
G
K
R
A
G
I
I
-
S
K
K
M
A
E
K
L
--
F
GKT
S
P
L
G
K
I
V
W
A
G
----
G
Q
P
V
E
V
I
------------
G
V
L
K
E
-------
G
L
S
E
M
Y
--
V
P
F
N
M
L
K
T
S
F
G
T
----
N
D
Y
S
N
V
S
V
Q
-----
T
E
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
40.68
26%
-91
- C10 -
3DH4
-
?
A:
[131-195]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
I
L
---
A
V
F
W
I
S
L
Y
I
---------
F
V
N
L
T
S
V
L
Y
L
G
G
L
------
A
L
E
T
I
L
G
I
P
L
M
Y
S
I
L
G
L
A
L
F
A
-----
L
V
--
Y
S
I
--------------------------------
V
V
W
T
D
V
I
Q
V
F
F
-
L
V
L
G
-
G
F
---
M
T
-------
T
Y
M
-----
A
V
----
S
F
-------
I
G
G
T
D
G
W
F
A
G
V
S
K
------
M
----------------
5
PsiBlast_PDB
35.77
30%
-48
- C10 -
1JMU
1
?
B:
[102-174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
--
C
Y
V
G
V
S
A
R
Q
A
L
N
N
F
Q
K
Q
V
P
V
I
T
P
T
R
Q
T
M
Y
V
D
S
I
Q
A
-----
A
L
--
K
A
L
E
K
W
E
I
D
--------------------------
L
R
V
A
Q
T
L
L
P
-----
T
N
-
V
P
---
I
G
-------
E
-
V
-----
S
C
----
P
M
-------
Q
S
V
V
--------------------------------
21
Fugue
34.61
40%
98
- C10 -
4QKC
6
M2_I72A2
A:
[2-26]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
S
D
P
-------
L
V
V
A
A
S
I
I
G
I
L
H
---
L
I
L
W
I
L
D
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
32.89
40%
111
* C10 *
1NYJ
2
M2_I77AB
A:
[1-25]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
S
D
P
-------
L
V
V
A
A
S
I
I
G
I
L
H
---
L
I
L
W
I
L
D
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
32.86
40%
103
- C10 -
3C9J
3
M2_I97A1
B:
[1-25]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
S
D
P
-------
L
V
V
A
A
S
I
I
A
I
L
H
---
L
I
L
W
I
L
D
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
30.24
17%
162
- C10 -
1IXS
-
A:
[21-38]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
A
L
A
A
L
G
F
K
E
A
Q
A
R
A
V
V
------------------------------------------------------------------------------------------------------------------------------------------