@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0077c: (2016-04-19 )
MSTIDISAGTIHYEATGPETGRPVVFVHGYMMGGQLWRRVSERLAGRGLRCIAPTWPLGAHPKPLRPGADQTIGGVAGIVADVLAALELKDVVLVGNDTGGVVTQLVAVHYPERLGALVLTSCDAFEHFPPPILKPVILAAKSATLFRAAIQVMRAPAARNRAYAGLSHHNIDHLTRAWVRPALSNPAIAEDLRQLSLSLRTEVTTAVAARLPEFDKPALIAWSADDVFFALENGQRLAATIPRARFEVIEGARTFSMVDSPDRLADQLSTVAVRT
Atome Classification :
(20 SA)
----.........10........-.20........30.........40........50......---..60........70........80........90........-100...-.....110.......-------120---------------......-...130---.....----....-------140.......150.--------.....---.----------.-.-------160------...-----..---------.--..--170.-.-----.....180.......190.......200---....--....210.....----..220.......230..-...-..240.......250.......260.......270....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
S
T
I
D
ISA
G
T
-
I
H
Y
EATGP-ETG
R
P
V
V
F
V
H
G
Y
-
M
M
G
G
Q
L
W
R
R
V
S
E
R
L
AGRG
L
R
C
IAPTWP---LGAHPKPLRPGADQTI
G
G
V
A
G
I
V
A
D
V
L
A
A
LEL
K
D
V
V
L
V
GNDT-
G
-
G
V
V
T
-
Q
L
V
A
VH
Y
P
E
RL
G
A
L
V
-------L-----------------TSC
D
A
F
-EHFP-----P
P
I
L
K
----
P
V
I
L
-------AAK
S
A
T
L
F
R
A
A
--
I
--------
Q
V
M
RA---P----------A-A-------RN-------R
A
Y
-----AG---------L--SH--H
N
I
D
-
H
-----
L
T
R
A
W
V
RPALSN
P
A
I
A
E
D
L
R
Q
L
S
L
S
L
R
----
T
E
V
T
--
T
A
V
A
A
RLPEFDK----
P
A
L
I
A
WSAD
D
V
F
F
A
LEN-GQ
R
-
L
A
A
TI
P
R
A
R
F
E
V
IEGA
R
T
FSMVD
S
P
D
R
L
A
D
Q
L
S
T
VAVRT
1
PsiBlast_PDB
82.93
26%
-122
- C1 -
1BRT
1
BPOA2_STRAU
A:
[15-255]
---------------
L
Y
Y
E
D
H
G
---
T
G
Q
P
V
V
L
I
H
G
F
-
P
L
S
G
H
S
W
E
R
Q
S
A
A
L
L
D
A
G
Y
R
V
I
--
T
Y
D
---
R
R
G
F
G
Q
S
S
Q
P
T
T
G
Y
D
Y
D
T
F
A
A
D
L
N
T
V
L
E
T
L
D
L
Q
D
A
V
L
V
G
F
S
T
-
G
T
G
E
V
A
-
R
Y
V
S
S
Y
G
T
A
R
I
A
K
V
A
-------
F
-----------------
L
A
S
----------------
L
E
----
P
F
L
L
KTDDNPD
G
A
A
P
Q
E
F
F
D
G
I
--
V
--------
A
A
V
K
A
---
D
--------------------
R
Y
-------
A
F
Y
-----
T
G
---------
F
F
N
D
F
--
Y
N
L
D
-
E
NLGTR
I
S
E
E
A
V
R
N
S
W
N
T
A
A
S
G
--
G
F
F
A
A
A
A
A
P
----
T
T
W
Y
--
T
D
F
R
A
D
I
P
R
I
D
V
----
P
A
L
I
L
H
G
T
G
D
R
T
L
P
I
E
N
-
T
A
R
V
F
H
K
A
L
P
S
A
E
Y
V
E
V
E
G
A
-----------------------
9
PsiBlast_PDB
81.93
25%
-123
- C1 -
1BRO
-
BPOA2_STRAU
A:
[15-255]
---------------
L
Y
Y
E
D
H
G
---
T
G
Q
P
V
V
L
I
H
G
F
-
P
L
S
G
H
S
W
E
R
Q
S
A
A
L
L
D
A
G
Y
R
V
I
--
T
Y
D
---
R
R
G
F
G
Q
S
S
Q
P
T
T
G
Y
D
Y
D
T
F
A
A
D
L
N
T
V
L
E
T
L
D
L
Q
D
A
V
L
V
G
F
S
M
-
G
T
G
E
V
A
-
R
Y
V
S
S
Y
G
T
A
R
I
A
K
V
A
-------
F
-----------------
L
A
S
----------------
L
E
----
P
F
L
L
KTDDNPD
G
A
A
P
Q
E
F
F
D
G
I
--
V
--------
A
A
V
K
A
---
D
--------------------
R
Y
-------
A
F
Y
-----
T
G
---------
F
F
N
D
F
--
Y
N
L
D
-
E
NLGTR
I
S
E
E
A
V
R
N
S
W
N
T
A
A
S
G
--
G
F
F
A
A
A
A
A
P
----
T
T
W
Y
--
T
D
F
R
A
D
I
P
R
I
D
V
----
P
A
L
I
L
H
G
T
G
D
R
T
L
P
I
E
N
-
T
A
R
V
F
H
K
A
L
P
S
A
E
Y
V
E
V
E
G
A
-----------------------
3
PsiBlast_PDB
81.80
23%
-96
- C1 -
3RK4
1
DHAA_RHORH
A:
[15-287]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
---------------------------
A
C
M
E
F
I
R
P
F
P
TWDEW
P
E
F
A
R
----
E
T
F
Q
-------
A
F
R
T
A
D
V
G
R
E
L
--
I
--------
I
D
Q
N
A
FIE
G
----------
A
-
L
-------
P
K
-------
Y
V
V
-----
R
P
---------
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
-
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
----
P
K
L
L
F
W
G
T
P
G
F
I
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
F
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
4
PsiBlast_PDB
81.65
23%
-96
- C1 -
4FWB
5
DHAA_RHORH
A:
[12-284]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
---------------------------
A
C
M
E
F
I
R
P
F
P
TWDEW
P
E
F
A
R
----
E
T
F
Q
-------
A
F
R
T
A
D
V
G
R
E
L
--
I
--------
I
D
Q
N
A
FIE
G
----------
A
-
L
-------
P
K
-------
Y
V
V
-----
R
P
---------
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
-
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
----
P
K
L
L
F
W
G
T
P
G
F
I
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
F
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
6
PsiBlast_PDB
81.06
29%
-106
- C1 -
1A88
-
PRXC_STRLI
A:
[2-226]
------
T
V
T
T
S
D
G
T
N
I
F
Y
K
D
W
G
P
-
R
D
G
L
P
V
V
F
H
H
G
W
-
P
L
S
A
D
D
W
D
N
Q
M
L
F
F
L
S
H
G
Y
R
V
I
A
H
D
-----
R
R
G
H
G
R
S
D
Q
P
S
T
G
H
D
M
D
T
Y
A
A
D
V
A
A
L
T
E
A
L
D
L
R
G
A
V
H
I
G
H
S
T
G
G
-
G
E
V
A
-
R
Y
V
A
R
A
E
P
G
R
V
A
K
A
V
-------
L
-----------------
V
S
A
------
V
P
-----
P
V
M
V
K
SDTN
P
D
G
L
-------
P
L
E
V
F
D
E
F
R
A
A
--
L
--------
A
A
N
R
A
---
Q
F
Y
I
D
V
P
S
GPF
Y
-
G
-------
F
N
-------
R
E
G
-----
A
T
---------
V
--
S
Q
--
G
L
I
D
-
H
-----
W
---
W
L
Q
G
M
M
G
----
A
A
N
A
H
Y
E
C
I
A
A
F
----
S
E
----
T
D
F
T
D
D
L
K
R
I
D
V
----
P
V
L
V
A
H
G
T
D
D
---------------------------------------------------
5
PsiBlast_PDB
80.94
23%
-94
- C1 -
3G9X
3
DHAA_RHOSO
A:
[15-287]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
---------------------------
A
C
M
E
F
I
R
P
F
P
TWDEW
P
E
F
A
R
----
E
T
F
Q
-------
A
F
R
T
A
D
V
G
R
E
L
--
I
--------
I
D
Q
N
A
FIE
G
----------
A
-
L
-------
P
K
-------
C
V
V
-----
R
P
---------
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
-
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
----
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
2
PsiBlast_PDB
80.93
23%
-94
* C1 *
3FWH
4
DHAA_RHOSO
A:
[15-287]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
---------------------------
A
C
M
E
F
I
R
P
F
P
TWDEW
P
E
F
A
R
----
E
T
F
Q
-------
A
F
R
T
A
D
V
G
R
E
L
--
I
--------
I
D
Q
N
A
FIE
G
----------
A
-
L
-------
P
K
-------
Y
V
V
-----
R
P
---------
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
-
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
----
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
13
PsiBlast_PDB
79.90
26%
-118
- C1 -
4IVJ
-
BPOA2_STRAU (first)
A:
[15-255]
---------------
L
Y
Y
E
D
H
G
---
T
G
T
P
V
V
L
I
H
G
F
-
P
L
S
G
H
S
W
E
R
Q
S
A
A
L
L
D
A
G
Y
R
V
I
--
T
Y
D
---
R
R
G
F
G
Q
S
S
Q
P
T
T
G
Y
D
Y
D
T
F
A
A
D
L
N
T
V
L
E
T
L
D
L
Q
D
A
V
L
V
G
F
S
M
-
G
T
G
E
V
A
-
R
Y
V
S
S
Y
G
T
A
R
I
A
A
V
A
-------
F
-----------------
L
A
S
----------------
L
E
----
P
F
L
L
KTDDNPD
G
A
A
P
Q
E
F
F
D
G
I
--
V
--------
A
A
V
K
A
---
D
--------------------
R
Y
-------
A
F
Y
-----
T
G
---------
F
--
F
N
D
F
Y
N
L
D
-
E
NLGTR
I
S
E
E
A
V
R
N
S
W
N
T
A
A
S
G
G
F
F
A
A
A
A
A
P
------
T
T
W
Y
--
T
D
F
R
A
D
I
P
R
I
D
V
----
P
A
L
I
L
H
G
T
G
D
R
T
L
P
I
E
N
-
T
A
R
V
F
H
K
A
L
P
S
A
E
Y
V
E
V
E
G
A
-----------------------
20
PsiBlast_PDB
79.23
22%
-109
- C1 -
4F60
1
DHAA_RHORH
A:
[15-287]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
EFIRP
I
-----------------
P
T
W
D
E
W
-
P
E
F
---------
A
R
----
E
L
F
Q
-------
A
F
R
T
A
D
V
G
R
E
L
--
I
IDQNAFIE
Q
V
L
P
K
---
F
----------
V
-
V
-------
R
-----------------
P
---------
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
-
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
----
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
12
PsiBlast_PDB
78.84
26%
-117
- C1 -
4ITV
-
BPOA2_STRAU (first)
A:
[15-255]
---------------
L
Y
Y
E
D
H
G
---
T
G
T
P
V
V
L
I
H
G
F
-
P
L
S
G
H
S
W
E
R
Q
S
A
A
L
L
D
A
G
Y
R
V
I
--
T
Y
D
---
R
R
G
F
G
Q
S
S
Q
P
T
T
G
Y
D
Y
D
T
F
A
A
D
L
N
T
V
L
E
T
L
D
L
Q
D
A
V
L
V
G
F
S
M
-
G
T
G
E
V
A
-
R
Y
V
S
S
Y
G
T
A
R
I
A
A
V
A
-------
F
-----------------
L
A
S
----------------
L
E
----
P
F
L
L
KTDDNPD
G
A
A
P
Q
E
F
F
D
G
I
--
V
--------
A
A
V
K
A
---
D
--------------------
R
Y
-------
A
F
Y
-----
T
G
---------
F
--
F
N
D
F
Y
N
L
D
-
E
NLGTR
I
S
E
E
A
V
R
N
S
W
N
T
A
A
S
G
G
F
F
A
A
A
A
A
P
------
T
T
W
Y
--
T
D
F
R
A
D
I
P
R
I
D
V
----
P
A
L
I
L
H
G
T
G
D
R
T
L
P
I
E
N
-
T
A
R
V
F
H
K
A
L
P
S
A
E
Y
V
E
V
E
G
A
-----------------------
79
HHSearch
78.52
21%
-107
- C1 -
3G9X
3
DHAA_RHOSO
A:
[14-292]
------
Y
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
-
P
S
H
R
C
I
A
P
D
L
I
---
G
M
G
K
S
D
K
P
--
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
-------
C
-----------------
M
E
F
I
R
P
-
F
P
T
W
-----
D
E
-
W
P
----
E
F
A
R
--------
E
T
F
-
Q
A
F
R
T
A
D
V
G
R
-------
E
L
I
I
D
---
Q
----------
N
A
F
-------
I
E
-------
G
A
L
P
K
C
VV
R
P
---------
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
-
E
P
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
----
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
-
19
PsiBlast_PDB
78.30
22%
-109
- C1 -
4WCV
3
DHAA_RHORH
A:
[15-287]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
EFIRP
I
-----------------
P
T
W
D
E
W
-
P
E
F
---------
A
R
----
E
L
F
Q
-------
A
F
R
T
A
D
V
G
R
E
L
--
I
IDQNAFIE
Q
V
L
P
K
---
G
----------
V
-
V
-------
R
P
--------------------------
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
-
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
----
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
11
PsiBlast_PDB
78.23
26%
-114
- C1 -
4IQ4
-
BPOA2_STRAU (first)
A:
[15-255]
---------------
L
Y
Y
E
D
H
G
---
T
G
T
P
V
V
L
I
H
G
F
-
P
L
S
G
H
S
W
E
R
Q
S
A
A
L
L
D
A
G
Y
R
V
I
--
T
Y
D
---
R
R
G
F
G
Q
S
S
Q
P
T
T
G
Y
D
Y
D
T
F
A
A
D
L
N
T
V
L
E
T
L
D
L
Q
D
A
V
L
V
G
F
S
M
-
G
T
G
E
V
A
-
R
Y
V
S
S
Y
G
T
A
R
I
A
A
V
A
-------
F
-----------------
L
A
S
----------------
L
E
----
P
F
L
L
KTDDNPD
G
A
A
P
Q
E
F
F
D
G
I
--
V
--------
A
A
V
K
A
---
D
--------------------
R
Y
-------
A
F
Y
-----
T
G
---------
F
--
F
N
D
F
Y
N
L
D
-
E
NLGTR
I
S
E
E
A
V
R
N
S
W
N
T
A
A
S
G
G
F
F
A
A
A
A
A
P
------
T
T
W
Y
--
T
D
F
R
A
D
I
P
R
I
D
V
----
P
A
L
I
L
H
G
T
G
D
R
T
L
P
I
E
N
-
T
A
R
V
F
H
K
A
L
P
S
A
E
Y
V
E
V
E
G
A
-----------------------
10
PsiBlast_PDB
77.90
22%
-98
- C1 -
4HZG
1
DHAA_RHOSO
A:
[15-287]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
---------------------------
A
C
M
E
F
-------------
I
R
----
P
I
P
T
-------
W
D
E
W
P
E
F
A
R
E
T
--
F
--------
Q
A
F
R
T
---
A
----------
D
-
V
G
R
E
L
IID
Q
N
-------
A
F
I
-----
E
G
A
L
P
K
C
VVRP
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
-
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
----
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
98
Fugue
77.69
25%
-94
- C1 -
1A88
-
PRXC_STRLI
A:
[1-275]
G
T
V
T
T
S
D
----
G
T
N
-
I
F
Y
K
D
W
G
P
R-
D
G
L
P
V
V
F
H
H
G
W
P
L
S
A
D
D
-
W
D
N
Q
M
L
F
F
L
S
H
G
Y
R
V
I
A
H
D
R
R
GHG
R
S
D
Q
P
S
T
-----
G
H
D
M
D
T
Y
A
A
D
V
A
A
L
T
E
A
L
D
L
R
G
A
V
H
I
G
H
S
T
-
G
-
G
G
E
V
A
R
Y
V
A
R
A
E
P
G
R
V
A
K
A
V
-------
L
V
SAVPPVMVKSDTNPDG
L
P
L
E
V
F
-
D
E
F
R
----------------
A
A
-------
L
A
A
------
N
R
--
A
--------
Q
F
Y
I
D
---
V
----------
P
-
S
-------
G
P
FYGFNRE--
G
-----
A
T
---------
V
--
S
Q
--
G
L
I
D
-
H
-----
W
W
L
Q
G
M
M
-
G
A
A
N
A
H
Y
E
C
I
A
A
F
S
E
-----------
T
--
D
F
-
T
D
D
L
K
----
R
ID
V
P
V
L
V
A
H
G
T
D
D
Q
V
V
P
Y
A
D
A
A
P
K
-
S
A
E
L
L
A
N
A
T
L
K
S
Y
E
G
L
P
H
G
M
L
S
T
H
P
E
V
L
N
P
D
L
L
A
F
V
K
S
-
8
PsiBlast_PDB
77.15
22%
-94
- C1 -
3FBW
8
?
A:
[15-287]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
---------------------------
A
C
M
E
F
-------------
I
R
----
P
I
P
T
-------
W
D
E
W
P
E
F
A
R
E
T
--
F
--------
Q
A
F
R
T
---
A
----------
D
-
V
G
R
E
L
IID
Q
N
-------
A
F
I
-----
E
G
A
L
P
K
Y
VVRP
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
-
L
W
R
F
P
N
E
L
P
I
A
G
E
P
A
N
I
V
A
L
V
--
E
A
Y
M
N
W
L
H
Q
S
P
V
----
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
16
PsiBlast_PDB
76.62
22%
-92
- C1 -
1BN7
1
DHAA_RHOSD
A:
[15-287]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
---------------------------
A
C
M
E
F
-------------
I
R
----
P
I
P
T
-------
W
D
E
W
P
E
F
A
R
E
T
--
F
--------
Q
A
F
R
T
---
A
----------
D
-
V
G
R
E
L
I
ID
Q
N
-------
A
F
I
-----
E
G
V
L
P
K
C
VVRP
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
L
W
R
F
P
N
E
I
P
I
A
G
E
P
----
A
N
I
V
--
A
L
V
E
A
Y
M
N
W
L
H
Q
SP
V
-
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
14
PsiBlast_PDB
76.30
22%
-92
- C1 -
1CQW
2
DHAA_RHOSD
A:
[12-284]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
---------------------------
A
C
M
E
F
-------------
I
R
----
P
I
P
T
-------
W
D
E
W
P
E
F
A
R
E
T
--
F
--------
Q
A
F
R
T
---
A
----------
D
-
V
G
R
E
L
IID
Q
N
-------
A
F
I
-----
E
G
V
L
P
K
C
VVRP
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
L
W
R
F
P
N
E
I
P
I
A
G
E
P
----
A
N
I
V
--
A
L
V
E
A
Y
M
N
W
L
H
Q
SP
V
-
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------
17
PsiBlast_PDB
75.47
26%
-108
- C1 -
3VDX
-
BPOA2_STRAU (first)
A:
[15-255]
---------------
L
Y
Y
E
D
H
G
---
T
G
V
P
V
V
L
I
H
G
F
-
P
L
S
G
H
S
W
E
R
Q
S
A
A
L
L
D
A
G
Y
R
V
I
--
T
Y
D
---
R
R
G
F
G
Q
S
S
Q
P
T
T
G
Y
D
Y
D
T
F
A
A
D
L
N
T
V
L
E
T
L
D
L
Q
D
A
V
L
V
G
F
S
M
-
G
T
G
E
V
A
-
R
Y
V
S
S
Y
G
T
A
R
I
A
A
V
A
-------
F
-----------------
L
A
S
----------------
L
E
----
P
F
L
L
KTDDNPD
G
A
A
P
Q
E
F
F
D
G
I
--
V
--------
A
A
V
K
A
---
D
--------------------
R
Y
-------
A
F
Y
-----
T
G
---------
F
--
F
N
D
F
Y
N
L
D
E
N
-----
L
G
T
R
I
S
E
E
A
V
R
N
S
W
N
T
A
A
S
G
G
F
F
A
A
A
A
----
A
P
T
T
WY
T
D
F
R
A
D
I
P
R
I
D
V
----
P
A
L
I
L
H
G
T
G
D
R
T
L
P
I
E
N
-
T
A
R
V
F
H
K
A
L
P
S
A
E
Y
V
E
V
E
G
A
-----------------------
15
PsiBlast_PDB
75.35
22%
-93
- C1 -
1BN6
-
DHAA_RHOSD
A:
[26-298]
-------
V
E
V
L
G
E
R
-
M
H
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
-
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
-
R
C
I
A
P
D
-----
L
I
G
M
G
K
S
D
K
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
-
G
-
S
A
L
G
-
F
H
W
A
K
R
N
P
E
R
V
K
G
I
---------------------------
A
C
M
E
F
-------------
I
R
----
P
I
P
T
-------
W
D
E
W
P
E
F
A
R
E
T
--
F
--------
Q
A
F
R
T
---
A
----------
D
-
V
G
R
E
L
IID
Q
N
-------
A
F
I
-----
E
G
V
L
P
K
C
VVRP
L
--
T
E
--
V
E
M
D
-
H
-----
Y
R
E
P
F
L
K
P
V
D
R
E
P
L
W
R
F
P
N
E
I
P
I
A
G
E
P
----
A
N
I
V
--
A
L
V
E
A
Y
M
N
W
L
H
Q
SPV-
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
-
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
------