@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0087: (2016-04-19 )
MMSASWLRHRVSERGLIATAEQLWADSFRLALVAAHDDGDSLRVVYLFLAGYPDRRVELEYVVPADNPEIRSLAYLSFPAGRFEREMADLYGIRPVGHPKPRRLVRHAHWPDWHPMRTDAGPAPEFTDTGAFPFLAVEGPGVYEIPVGPVHAGLIEPGHFRFSVAGETIVRLKARLWFVHRGIEKLFHGRPATAAVDLAERISGDTSAAHALAHSLAIEDALGIELPHEVHRLRALIVELERLYNHAADLGALANDVGYSLANAHAQRIRENLLRRNAAVTGHRLLRGAIRAGGVALRALPDTDELAALAVDLAEVATLTLANSVVYDRFAGTAVLHPDDASALGCLGYVARASGLRSDARVEHPTIVLPITEIGAPDGDVLARYTVRRDEFAASAALAQHIVESHTGPIEYAATLHPVGAPSSGIGIVEGWRGTIVHRVEIDVDGRITRAKVVDPSWFNWPALPVAMADTIVPDFPLANKSFNQSYAGNDL
Atome Classification :
(20 SA)
-------------------------------------------------.....--------....10.---......--.20.....----.-..30.-...---------------------..-..----40---.........50........---60........70.--.-----------...---------...---80---....---------------....--------------.90...-.....100.......110....-...120.......130..-------------------.....140.......-150....--------------------------------..-----.160--...--.-------------------...170........180--.....-----..190-.....-...200.......210...---....220.......230----------.-......----.240-----.......----..250..-.-..----..260-----------------------------------.----------------------------------------------------------------------.----------------------------------------------------------------------.----------------------------------------------------------------------.-.....270....-------------...------.-----280----........290------------------....---------------..-----------.--300---------..------.-----..----....310.--...-.-------------.----.--------------------320--------------.------------.------------------.---------------.--------.---------------.--------..330.------------------....--.-----.---------------------------------------------340--------------.----.--------------------------------------------------.----------.---------------....---.350.-------------.-------------..----.----..-----.-------------------------------------------360--------------------------------------------.-----------------------------------------------.--------------------------------------------.---------.--..-..370----------.--------------------------.-----.------.----------------.-----------------------------....-380.......-------------------390....----...------------400..-...-.-.--------410---------.----.------.--------..--..--..----------420.......430.......440----.........450....---------------------------...460---...---------.---------.---------.--..470...-----------.------....480-----------...--....490--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------MM
S
A
S
--------
W
L
R
H
R
V
S---ERG
L
I
A
--
T
A
E
Q
L
W
AD----S-
F
R
L
A
L
-
V
A
A---------------------HD-DG----D----
S
L
R
V
V
Y
L
F
LAGYPD
R
R
V
E
L
---
E
Y
V
VPADNPE
I
R
S
--
L
-----------
A
Y
L---------SFP---A----
G
R
F
E
---------------
R
E
M
A
--------------
D
LYGIR-PVGHP
K
P
R
R
L
V
RHAHWPDWHPM-RTDAGPAPEFTDTGAF
P
F
-------------------
L
A
VEGP
G
V
Y
EIPVGP-VHAGLIE--------------------------------PG-----
H
F
R
F
--
S
VA--G-------------------
E
T
I
V
R
-
L
K
A
R
L
W
F
V
H
R
G
--
I
E
K
L
F-----HGRP--
A
T
A
A
V
-
D
L
A
E
R
ISGD
T
S
A
A
H
A
L
A
H
S
---
L
AIEDALGIEL
P
H
E
V
H
-----------
R
-
L
R
A
L
I
V
----
E
L
-------
E
R
L
Y
N
H
A
----
A
D
L
G
A
L
A
-
N
-
D
V
----
G
Y
S
-------------------------------------
L
----------------------------------------------------------------------
A
----------------------------------------------------------------------
N
----------------------------------------------------------------------
A
-
H
A
Q
R
I
R
E
-
N
L
L
R-------------RNA------A-----V
T
-----
G
H
R
L
L
R
G
A
I
R
A------------------G
G
V
A
---------------
L
R-----------A--L-----------P
D
------
T
-----
D
E
----
L
A
A
L
A
V
D
L
--
A
E
V
-
A
-------------
T
----
L
--------------------
T
L
---------------
A
------------
N
------------------
S
---------------
V
--------
V
---------------
Y
--------DRFA
G
T
------------------
A
V
LH--P-----D---------------------------------------------D----------------A----
S
--------------------------------------------------
A
----------
L
---------------
G
C
L
G
---
Y
V
A
-
R
-------------
A
-------------SG----L----RS-----D-------------------------------------------AR---------------------------------------------V-----------------------------------------------E--------------------------------------------H---------
P
--
T
I
-
V
L
P
------------I--------------------------T-----E------I----------------G-----------------------------AP
D
G
-
D
V
L
A
R
Y
T
V
R
R
-------------------
D
E
F
A
A
S
A
----
A
L
A
------------
Q
H
I
V
E
-SHT-G-P--------
I
-----------
E
----
Y
------
A
--------
A
T
--LH--PV----------GAPSSGIGIVEGWR
G
T
I
V
H
R
V
------
E
I
DVDG
R
I
T
R
A
K
VVDP---------------------------SWFNW----PAL---------
P
---------
V
---------
A
--
M
A
D
T-IVP-----------D------FPLANKS-----------FNQ--SYAGNDL--------------------
33
Fugue
91.36
27%
-67
- C1 -
4CI0
4
?
A:
[2-386]
--------------------------------------------------------------------
S
---
E
R
I
V
I
S
---------------------------------------------------------------------------------------------------------------------------
P
---
T
----
S
R
Q
E
------------------------------------------
G
H
---------------------------------
A
E
L
V
-------------------
M
E
V
D
D
E
G
I
-------------
V
T
--------------------------------
K
G
-----
R
Y
-
F
--
S
I
T
--
P
-------------------
V
--------------
R
G
--
L
E
K
M
V
-----
T
G
K
A
--
P
E
T
A
P
-
V
M
V
Q
R
I
C
G
V
C
P
I
P
H
T
L
A
S
V
---
E
A
I
D
D
S
L
D
I
E
V
P
K
A
G
R
-----------
L
-
L
R
E
L
T
L
----
A
A
-------
H
H
V
N
S
H
A
----
I
H
H
F
L
I
A
-
P
-
D
F
VPEN
L
M
A
-------------------------------------
D
----------------------------------------------------------------------
A
----------------------------------------------------------------------
I
----------------------------------------------------------------------
N
-
S
V
S
E
I
R
K
-
N
A
Q
Y
-------------
V
V
D
------
M
-----
V
A
-----
G
E
G
I
H
P
S
D
V
R
I
------------------
G
G
M
A
D
N
I
T
E
L
A
R
K
R
L
Y
A
R
L
K
Q
-----------
L
--
K
-----------
P
K
------
V
-----
N
E
----
H
V
E
L
M
I
G
L
--
I
E
D
-
K
-------------
G
----
L
PEGLGVHN
Q
P
----------
T
L
---------------
A
------------
S
------------------
H
---------------
Q
--------
I
---------------
Y
GDRTKFDL
D
R
F
T
E
I
M
P----------------
E
S
W
Y
--
D
-----
D
---------------------------------------------
P
----------------
E
----
I
--------------------------------------------------
A
----------
K
---------------
R
A
C
S
---
T
I
P
-
L
-------------
Y
-------------
D
G
------------------------------------------------------------
R
N
---------------------------------------------
V
-----------------------------------------------
E
--------------------------------------------
V
---------
G
--
P
R
-
A
R
M
------------
V
--------------------------
E
-----
F
------
Q
----------------
G
-----------------------------
F
K
E
R
-
G
V
V
A
Q
H
V
A
R
A
-------------------
L
E
M
K
T
A
L
----
S
R
A
------------
I
E
I
L
D
-
E
L
D
-
T
-
S
--------
A
-----------
P
----
V
------
R
--------
A
D
--
F
D
--
E
R
----------
G
T
G
K
L
G
I
G
A
I
E
A
P
R
G
L
D
V
H
M
A
------
K
V
E
-
N
G
K
I
Q
F
Y
S
A
L
V
P
---------------------------
T
T
W
N
I
----
P
T
M
---------
G
---------
P
---------
A
--
T
E
G
F
-
H
H
E
-----------
Y
------
G
P
H
V
I
R
A
-----------
Y
D
P
CL
S
C
A
T
H
----------------------
42
HHSearch
83.06
22%
-63
- C1 -
4OMF
6
?
A:
[5-385]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
I
S
P
-
T
S
R
-
Q
E
G
--------------------------------
H
A
-----
E
L
V
M
--
E
V
D
--
D
-------------------
E
G
I
V
T
K
G
R
Y
F
S
I
T
P
V
R
G
--
L
E
K
M
V
-----
T
G
K
A
--
P
E
T
A
P
-
V
M
V
Q
R
I
C
G
V
C
P
I
P
H
T
L
A
S
V
---
E
A
I
D
D
S
L
D
I
E
V
P
K
A
G
R
-----------
L
-
L
R
E
L
T
L
----
A
A
-------
H
H
V
N
S
H
A
----
I
H
H
F
L
I
A
-
P
-
D
F
----
V
P
E
NL
M
A
---------------------------------
D
----------------------------------------------------------------------
A
----------------------------------------------------------------------
I
----------------------------------------------------------------------
N
-
S
V
S
E
I
R
K
-
N
A
Q
Y
-------------
V
V
D
------
M
-----
V
A
-----
G
E
G
I
H
P
S
D
V
R
I
------------------
G
G
M
A
---------------
D
N
-----------
I
--
T
-----------
E
L
------
A
R
K
R
L
Y
A
R
----
L
K
Q
L
K
P
K
V
--
N
E
H
-
V
-------------
E
----
L
--------------------
M
I
---------------
G
------------
L
------------------
I
---------------
E
--------
D
---------------
K
--------
G
L
P
E
G
L
------------------
G
V
H
N
--
Q
-----
P
---------------------------------------------
T
----------------
L
----
A
--------------------------------------------------
S
----------
H
---------------
Q
I
Y
G
---
D
--------------------------------
R
----
T
----
K
F
-----
D
-------------------------------------------
L
D
---------------------------------------------
R
F
T
E
--------------------------------------------
I
--------------------------------------------
M
---------
P
--
E
S
-
W
Y
D
------------
D
P
E
I
A
K
R
AC
S
T
I
P
L
Y
DG
R
N
V
E
V
G
P
R
A
R
M
V
E
---
F
------
Q
----------------
G
-----------------------------
F
K
E
R
-
G
V
V
A
Q
H
V
A
R
A
-------------------
L
E
M
K
T
A
L
----
S
R
A
------------
I
E
I
L
D
-
E
L
D
T
S
A
P
--------
V
-----------
R
----
A
------
D
--------
F
----
D
--
E
R
----------
G
T
G
K
L
G
I
G
A
I
E
A
P
R
G
L
D
V
H
M
A
------
K
V
E
-
N
G
K
I
Q
F
Y
S
A
L
V
P
---------------------------
T
T
W
N
I
----
P
T
M
---------
G
---------
P
---------
A
--
T
E
G
F
-
H
H
E
-----------
Y
------
G
P
H
V
I
R
A
-----------
Y
D
P
--
C
L
S
C
A
T
---------------------
49
HHSearch
80.69
21%
-55
- C1 -
4U9H
15
PHNL_DESVM
L:
[5-532]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
V
V
D
P
-
V
T
R
-
I
E
G
--------------------------------
H
L
-----
R
I
E
V
--
E
V
E
--
N
-------------------
G
K
V
K
N
-
A
Y
S
-
S
S
T
L
F
R
G
--
L
E
I
I
L
-----
K
G
R
D
--
P
R
D
A
Q
-
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
---
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
-----------
Y
-
I
R
N
L
V
L
----
G
A
-------
Q
Y
L
H
D
H
I
----
V
H
F
Y
H
L
H
A
L
-
D
F
----
V
D
V
-------------------------------------
T
----------------------------------------------------------------------
A
ALKADPAKAAKVASSISPRKTTAADLKAVQDKLKTFVESGQLGPFTNAYFLGGHPAYYLDPETNLIATAH
Y
----------------------------------------------------------------------
L
-
E
A
L
R
L
Q
V
-
K
A
A
R
-------------
A
M
A
------
V
-----
F
G
-----
A
K
N
P
H
T
Q
F
T
V
V
------------------
G
G
V
T
---------------
C
Y
-----------
D
AL
T
-----------
P
Q
------
R
I----
A
E
----
F
E
A
L
W
K
E
T
--
K
A
F
V
D
-------------
E
----
V
--------------------
Y
I
PDLLVVAAAYK----
D
WTQYGGTDNFIT
F
------------------
G
---------------
E
FPKDEYD-
L
---------------
N
--------
S
R
F
F
K
P
------------------
G
V
V
F
--
K
-----
R
DFKNIKPFDKMQIEEHVRHSWYEGAEARHPWKGQTQPKYTDLHGD
D
----------------
R
----
Y
--------------------------------------------------
S
WMKAPRYMGE
P
---------------
M
E
T
G
---
P
L
A
-
Q
VLIAY--------
S
-------------
Q
G
---------
H
P
-----
K
-------------------------------------------
V
K
---------------------------------------------
A
-----------------------------------------------
V
------------------------------------------------------
T
--
D
A
-
V
L
A
------------
K
--------------------------
L
G----
V
------
G
----------------
P
-----------------------------
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
-------------------
I
E
T
A
V
I
A
----
E
Y
V
------------
G
V
M
L
Q
-
E
Y
K
D
N
-
I
--------
A
-----------
K
----
G
------
D
NVI-----
C
A
--
P
W
--
E
M
----------
P
K
Q
A
E
G
V
G
F
V
N
A
P
R
G
G
L
S
H
W
I
------
R
I
E
-
D
G
K
I
G
N
F
Q
L
V
V
P
---------------------------
S
T
W
T
L
----
G
P
R
CDKNKLSPV
E
---------
A
---------
S
--
L
I
G
T
-
P
V
A
-----------
D
AKRPVE
I
L
R
T
V
H
S
-----------
F
D
P
--
C
I
A
C
G
V
---------------------
20
PsiBlast_PDB
78.51
24%
-70
- C1 -
4CI0
4
?
A:
[41-358]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
--
L
E
K
M
V
-----
T
G
K
A
--
P
E
T
A
P
-
V
M
V
Q
R
I
C
G
V
C
P
I
P
H
T
L
A
S
V
---
E
A
I
D
D
S
L
D
I
E
V
P
K
A
G
R
-----------
L
-
L
R
E
L
T
L
----
A
A
-------
H
H
V
N
S
H
A
----
I
H
H
F
L
I
A
-
P
-
D
------
F
V
-------------------------------------
P
----------------------------------------------------------------------
E
----------------------------------------------------------------------
N
----------------------------------------------------------------------
L
-
M
A
D
A
I
N
S
V
S
E
I
R
-------------
K
N
A
------
Q
Y
V
V
D
M
V
A
-----
G
E
G
I
H
P
S
D
V
R
I
------------------
G
G
M
A
D
N
I
T
E
L
A
R
K
R
L
Y
A
R
-
L
K
-----------
Q
--
L
K----------
P
K
------
V
-----
N
E
----
H
V
E
L
M
I
G
L
--
I
E
D
-
K
-------------
G
----
L
PEGLGVHN
Q
P
----------
T
L
---------------
A
------------
S
------------------
H
---------------
Q
--------
I
---------------
Y
GDRTKFDL
D
R
F
--
T
------------------
E
I
M
---
P
-----
E
SWYDD
P
---------------------------------------
E
----------------
I
----
A
--------------------------------------------------
K
----------
R
---------------
A
C
S
T
I
P
L
Y
D
G
-
R
-------------
N
-------------
V
E
----
V
----
G
P
-----
R
-------------------------------------------
A
R
---------------------------------------------
M
---------------------------------------------------------------------------------------------------------------------------
V
--------------------------
E
-----
F
------
Q
----------------
G
-----------------------------
F
K
E
R
-
G
V
V
A
Q
H
V
A
R
A
-------------------
L
E
M
K
T
A
L
----
S
R
A
------------
I
E
I
L
D
-
E
L
D
-
T
-
S
--------
A
-----------
P
----
V
------
R
--------
A
D
--
F
D
--
E
R
----------
G
T
G
K
L
G
I
G
A
I
E
A
P
R
G
L
D
V
H
M
A
------
K
V
E
-
N
G
K
I
Q
F
Y
S
A
L
V
P
---------------------------
T
T
W
N
I
----
P
T
M
------------------------------------------------------------------------------------------------------------
47
HHSearch
78.16
20%
-58
- C1 -
1E3D
5
?
B:
[13-541]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
I
V
V
D
P
-
L
T
-
R
I
E
G
--------------------------------
H
L
-----
R
I
E
V
--
E
V
E
--
G
-------------------
G
V
I
K
E
-
A
R
S
-
C
A
T
L
F
R
G
--
I
E
T
I
L
-----
K
G
R
D
--
P
R
D
A
Q
-
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
---
R
C
L
E
D
A
I
N
K
P
I
P
A
N
A
T
-----------
Y
-
I
R
N
L
V
L
----
G
N
-------
Q
F
M
H
D
H
L
----
V
H
F
Y
H
L
H
A
L
-
D
F
----
V
D
V
-------------------------------------
T
----------------------------------------------------------------------
S
----------------------------------------------------------------------
A
L
L
AD
P
A
K
A
A
K
L
A
N
S
I
SPRKAT
T
E
E
F
A
A
V
Q
A
K
L
K
T
F
V
A
S
GQLGPFTNAYFLGGHEG
Y
Y
M
D
P
E
A
N
L
V
C
T
A
H
Y
L
-
Q
A
L
R
A
Q
V
-
E
V
A
K
-------------
G
M
A
------
V
-----
F
G
-----
A
K
N
P
H
T
Q
F
T
V
A
------------------
G
G
V
T
---------------
C
Y
-----------
E
--
A
LT---------
P
E
------
R
I
----
K
Q
----
F
R
E
L
Y
V
K
A
--
R
A
F
I
E
-------------
E
----
V
--------------------
Y
I
---------------
P
D
L
L
L
V
A
S
Y
----
Y
------------------
K
DWGKIGGT
N
N
F
M
A
FG
E
--------
F
PAPGGERDL------
N
--------
S
R
W
Y
K
P
------------------
G
V
I
Y
--
D
-----
R
KVGS
V
Q
P
F
D
PSK
I
E
E
H
V
RHSWYEGKARAPFE
G
E
T
N
P
H
F
T
F
MGDT-
D
----------------
K
----
Y
--------------------------------------------------
S
----------
W
N
K
A
P
R
Y
DG
H
A
-----
V
E
T
G
---
P
L
A
-
Q
-------------
M
-------------
L
V
---------
A
Y
G
H
NHK
T
-------------------------------------------
I
K
---------------------------------------------
P
-----------------------------------------------
T
------------------------------------------------------
I
--
D
A
-
V
L
G
------------
K
--------------------------
L
N----
L
------
G
----------------
P
-----------------------------
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
-------------------
I
Q
T
L
V
I
A
----
Q
Q
M
------------
E
N
W
L
N
-
E
Y
E
N
N
-
I
--------
V
-----------
K
----
D
------
K
QI------
V
E
--
D
Y
--
A
V
----------
P
T
S
A
R
G
V
G
F
A
D
V
S
R
G
G
L
S
H
W
M
------
T
I
E
-
D
G
K
I
D
N
F
Q
L
V
V
P
---------------------------
T
T
W
N
L
----
G
P
R
---------
D
DKGVPS
A
A
E
A
---------
A
--
L
V
G
T
-
P
V
A
-----------
D
PKRP
V
E
I
L
R
T
I
H
S
-----------
F
D
P
--
C
I
A
C
S
T
---------------------
53
HHSearch
77.25
21%
-54
- C1 -
3MYR
4
?
B:
[5-560]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
D
P
-
I
T
R
-
I
E
G
--------------------------------
H
L
-----
R
I
E
A
--
Q
M
D
--
G
-------------------
A
T
I
A
Q
-
A
Y
-
S
S
G
T
M
V
R
G
--
I
E
T
I
L
-----
K
G
R
D
--
P
R
D
A
W
-
A
F
V
Q
R
I
C
G
V
C
T
L
V
H
G
I
A
S
V
---
R
A
V
E
D
A
L
R
I
E
L
P
L
N
A
Q
-----------
L
-
I
R
N
L
M
I
----
G
A
-------
Q
Y
I
H
D
H
V
----
M
H
F
Y
H
L
H
A
L
-
D
W
----
V
D
V
-------------------------------------
V
S
A
L
S
AD
P
R
A
T
S
E
L
A
Q
S
I
SAWPKSS
P
G
Y
F
A
D
T
Q
K
R
I
K
T
F
V
E
S
GQLGIFANGYWGHPA
Y
R
L
P
P
E
A
N
L
M
A
V
A
-
H
----------------------------------------------------------------------
Y
----------------------------------------------------------------------
L
-
E
A
L
A
W
Q
R
-
D
T
A
K
-------------
F
H
A
------
I
-----
F
G
-----
G
K
N
P
H
P
N
-
F
V
V
------------------
G
G
V
P
---------------
S
P
-----------
I
--
D
-----------
L
D
SDSALN
A
-----
K
R
----
L
A
E
V
R
N
L
I
--
Q
S
M
-
R
-------------
T
----
F
--------------------
V
D
---------------
Q
------------
V
Y
V
P
D
T
L
A
I
A
G
F
Y
K
D
W
G
E
R
G
---------------
E
--------
G
---------------
L
--------
G
N
F
L
C
Y
------------------
G
D
L
P
--
T
-----
G
---------------------------------------------
A
----------------
S
LDPA
T
--------------------------------------------------
F
----------
L
---------------
F
P
R
G
---
A
I
L
-
D
-------------
R
DLS
T
I
H
E
V
D
LEAT
G
E
----
I
----
Q
E
-----
F
VNHSWYEYSVGND
R
G
L
H
PYE
G
Q
T
N
L
E
YDRRGGVAPPYKQLDVS
D
G
---------------------------------------------
Y
-----------------------------------------------
S
W
L
K
A
P
R
W
KG
R
S
---------------------------------
V
---------
E
--
V
G
-
P
L
A
------------
R
--------------------------
V
L
----
M
L
Y
A
T
GH
D
Q
A
R
E
L
V
D
S
T
L
S
R
L
DLP
V
-----------------------------
D
A
L
Y
-
S
T
L
G
R
T
A
A
R
A
-------------------
L
E
S
K
I
L
V
----
D
A
M
------------
Q
G
W
Y
D
-
G
L
I
A
N
-
V
K
S
GD----
T
-----------
K
----
T
------
F
--------
N
E
TL
W
E
PS
S
W
----------
P
S
R
A
Q
G
V
G
I
M
E
A
P
R
G
A
L
G
H
W
I
------
V
I
E
-
D
G
R
I
A
N
Y
Q
A
V
V
P
---------------------------
S
T
W
N
A
----
G
P
R
---------
D
---------
G
RGQAG
A
Y
E
A
A
--
L
Q
D
N
H
Q
L
V
DVKQP
I
-----
E
------
I
L
R
T
I
H
S
-----------
F
D
P
--
C
I
A
C
A
V
---------------------
48
HHSearch
75.90
17%
-62
- C1 -
3AYX
15
?
A:
[16-595]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
R
V
V
I
D
P
-
V
T
-
R
I
E
G
--------------------------------
H
M
-----
R
C
E
V
--
N
V
D
--
E
-------------------
N
N
V
I
Q
-
N
A
V
S
T
G
T
M
W
R
G
--
L
E
V
I
L
-----
R
G
R
D
--
P
R
D
A
W
-
A
F
V
E
R
I
C
G
V
C
T
G
C
H
A
L
A
S
V
---
R
A
V
E
D
A
L
D
I
K
I
P
H
N
A
T
-----------
L
-
I
R
E
I
M
A
----
K
T
-------
L
Q
I
H
D
H
I
----
V
H
F
Y
H
L
H
A
L
-
D
W
----
V
N
P
-------------------------------------
V
N
A
L
K
AD
P
Q
A
T
S
E
L
Q
K
L
V
SPHHPMSS
P
G
Y
F
K
D
I
Q
I
R
I
Q
K
F
V
D
S
GQLGIFKNGYWSNPAYKLS
P
E
A
D
L
M
A
V
T
H
----------------------------------------------------------------------
Y
----------------------------------------------------------------------
L
-
E
A
L
D
F
Q
K
-
E
I
V
K
-------------
I
H
A
------
I
-----
F
G
-----
G
K
N
P
H
P
N
Y
M
-
V
------------------
G
G
V
P
---------------
C
A
INIDGDMAAGA
P
--
I
N----------
M
E
------
R
L
----
N
F
----
V
K
S
L
I
E
Q
G
--
R
T
F
-
N
-------------
T
N---
V
--------------------
Y
V
P
D
V
I
A
I
A
A
F
Y
R
DWLY
G
------------
G
------------------
G
---------------
L
--------
S
---------------
A
--------
T
N
V
M
D
Y
------------------
G
A
Y
P
--
K
-----
T
---------------------------------------------
P
----------------
Y
DKS-
T
--------------------------------------------------
D
----------
Q
---------------
L
P
G
G
---
A
I
I
N
G
DWG
K
I
H
P
V
D
PRD-
P
-------------
E
Q
----
V
----
Q
E
-----
F
-------------------------------------------
V
T
HSWYKYPDET
K
G
L
HPWD
G
I
T
E
P
N
YELGSKTKGSRTNIIEIDESAK
Y
-----------------------------------------------
S
--------------------------------------------
W
I
K
S
P
R
W
RG
H
A
V
E
V
G
-
P
L
A
------------
R
--------------------------
Y
I
----
L
A
Y
A
Q
GV
E
Y
---------------
V
K
T
Q
V
H
T
S
L
N
R
F
N
A
V
C
R
L
L
D
P
NHKDITD
L
K
A
F
L
G
-
S
T
I
G
R
T
L
A
R
A
-------------------
L
E
S
E
Y
C
G
----
D
M
M
------------
L
D
D
F
N
-
Q
L
I
S
N
-
I
--------
K
-----------
N
----
G
DSSTAN
T
--------
D
K
--
W
D
PS
S
W
----------
P
E
H
A
K
G
V
G
T
V
A
A
P
R
G
A
L
A
H
W
I
------
V
I
E
-
K
G
K
I
K
N
Y
Q
C
V
V
P
---------------------------
T
T
W
N
G
----
S
P
R
DPKGNIG
A
F
E
---------
A
---------
S
--
L
M
G
T
-
P
M
E
RPDEP
V
-----
E
------
V
L
R
T
L
H
S
-----------
F
D
P
--
C
L
A
C
S
T
---------------------
50
HHSearch
75.10
19%
-57
- C1 -
1YQ9
10
PHNL_DESGI
H:
[7-535]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
V
D
P
-
I
T
R
-
I
E
G
--------------------------------
H
L
-----
R
I
E
V
--
E
V
E
--
G
-------------------
G
K
I
K
N
-
A
W
S
M
-
S
T
L
F
R
G
--
L
E
M
I
L
-----
K
G
R
D
--
P
R
D
A
Q
-
H
F
T
Q
R
A
C
G
V
C
T
Y
V
H
A
L
A
S
V
---
R
A
V
D
N
C
V
G
V
K
I
P
E
N
A
T
-----------
L
-
M
R
N
L
T
M
----
G
A
-------
Q
Y
M
H
D
H
L
----
V
H
F
Y
H
L
H
A
L
-
D
W
----
V
N
V
-------------------------------------
A
NALNADPAKAARLANDLSPRKTTTESLKAVQAKVKALVESGQLGIFTNAYFLGGHPAYVLPAEVDLIATA
H
----------------------------------------------------------------------
Y
----------------------------------------------------------------------
L
-
E
A
L
R
V
Q
V
-
K
A
A
R
-------------
A
M
A
------
I
-----
F
G
-----
A
K
N
P
H
T
Q
F
T
V
V
------------------
G
G
C
T
---------------
N
Y
-----------
D
--
S
LR---------
P
E
------
R
I----
A
E
----
F
R
K
L
Y
K
E
V
--
R
E
F
-
I
E------------
Q
----
V
--------------------
Y
I
TDLLAVAGFYK----
N
------------
W
AGIGKTSNFLTC------
G
---------------
E
FPTDEYD-
L
---------------
N
--------
S
R
Y
T
P
Q
------------------
G
V
I
W
--
G
-----
N
DLSKVDDFNPDLIEEHVKYSWYEGADAHHPYKGVTKPKWTEFHGE
D
----------------
R
----
Y
--------------------------------------------------
S
WMKAPRYKGE
A
---------------
F
E
V
G
---
P
L
A
-
S
-------------
V
-------------
L
V
----
A
YAKK
H
E
-----
P
-------------------------------------------
T
V
---------------------------------------------
K
-----------------------------------------------
A
------------------------------------------------------
V
--
D
L
-
V
L
K
------------
T
--------------------------
L
G----
V
------
G
----------------
P
-----------------------------
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
-------------------
I
Q
C
L
T
A
A
----
Q
E
V
------------
E
V
W
L
D
-
K
L
E
A
N
-
V
--------
K
-----------
A
----
G
KDD---
L
--------
Y
T
--
D
W
--
Q
Y
----------
P
T
E
S
Q
G
V
G
F
V
N
A
P
R
G
M
L
S
H
W
I
------
V
Q
R
-
G
G
K
I
E
N
F
Q
L
V
V
P
---------------------------
S
T
W
N
L
----
G
P
R
CAEGKLSAV
E
---------
Q
---------
A
--
L
I
G
T
-
P
I
A
-----------
D
PKRPVE
I
L
R
T
V
H
S
-----------
Y
D
P
--
C
I
A
C
G
V
---------------------
51
HHSearch
73.21
17%
-59
- C1 -
4C3O
7
?
A:
[14-584]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
G
R
R
I
V
V
D
P
-
V
T
-
R
I
E
G
--------------------------------
H
M
-----
R
C
E
V
--
N
I
D
--
S
-------------------
N
N
V
I
T
-
N
A
V
S
T
G
T
M
W
R
G
--
L
E
V
I
L
-----
K
G
R
D
--
P
R
D
A
W
-
A
F
V
E
R
I
C
G
V
C
T
G
T
H
A
L
T
S
I
---
R
A
V
E
N
A
L
G
I
A
I
P
D
N
A
N
-----------
C
-
I
R
N
M
M
Q
----
A
T
-------
L
H
V
H
D
H
L
----
V
H
F
Y
H
L
H
A
L
-
D
W
----
V
D
V
-------------------------------------
V
A
A
L
K
AD
P
H
Q
T
S
A
I
A
Q
S
L
SAWPLSS
P
G
Y
F
R
D
L
Q
N
R
L
K
R
F
I
E
S
GQLGPFRNGYWGHPAMKLP
P
E
A
N
L
L
A
V
A
-
H
----------------------------------------------------------------------
Y
----------------------------------------------------------------------
L
-
E
A
L
D
F
Q
K
-
E
I
V
K
-------------
I
H
T
------
V
-----
F
G
-----
G
K
N
P
H
P
N
-
W
L
V
------------------
G
G
V
P
---------------
C
A
-----------
I
--
N
LDETGAVGAVN
M
E
------
R
L
----
N
L
----
V
S
S
I
I
Q
K
A
--
R
Q
F
C
E
-------------
Q
----
V
--------------------
Y
L
---------------
P
------------
D
------------------
V
---------------
L
L
I
A
S
Y
Y
KD
W
AKIGGGLS-------
S
--------
M
N
L
L
A
Y
------------------
G
E
F
P
--
D
-----
N
---------------------------------------------
P
----------------
N
----
D
YSASN---------------------------------------------
L
----------
L
---------------
L
P
R
G
---
A
I
I
-
N
GRFDEI
H
P
V
D
LTA
P
-------------
D
E
----
I
----
Q
E
-----
F
-------------------------------------------
V
T
---------------------------------------------
H
SWYTYGNGNND
K
G
L
H
PWDGLT
E
P
Q
L
V
M
G
EHYKGTKTFIEQVDESAKY
S
--------------------------------------------
W
I
K
S
P
R
W
KG
H
A
M
E
V
G
-
P
L
A
------------
R
--------------------------
Y
L
----
I
G
Y
H
Q
NK
P
E
F
K
E
P
V
D
Q
L
L
S
V
L
KLP
K
-----------------------------
E
A
L
F
-
S
T
L
G
R
T
A
A
R
A
-------------------
L
E
S
V
W
A
G
----
N
T
L
------------
Q
Y
F
F
D
-
R
L
M
R
N
-
L
--------
K
-----------
S
----
G
------
D
TATANVTL
W
E
--
P
D
--
T
W
----------
P
T
S
A
K
G
V
G
F
S
E
A
P
R
G
A
L
G
H
W
I
------
K
I
A
-
N
Q
K
I
D
S
Y
Q
C
V
V
P
---------------------------
T
T
W
N
A
----
G
P
R
DDKGQIG
A
Y
E
---------
A
---------
A
--
L
M
G
T
-
K
L
A
VPDQP
L
-----
E
------
I
L
R
T
L
H
S
-----------
F
D
P
--
C
L
A
C
S
T
---------------------
45
HHSearch
73.16
17%
-57
- C1 -
5AA5
3
?
C:
[19-578]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
V
E
M
N
W
D
P
-
I
T
R
-
I
V
G
--------------------------------
S
L
-----
G
I
Y
T
--
K
I
D
FE
N
-------------------
R
R
V
A
E
-
C
Y
S
-
T
S
S
I
F
R
G
--
Y
S
I
F
M
-----
K
G
K
D
--
P
R
D
S
H
-
F
I
T
S
R
I
C
G
I
C
G
D
N
H
A
T
C
S
V
---
Y
A
Q
N
M
A
Y
G
V
K
P
P
P
I
A
D
-----------
W
-
I
I
N
L
G
E
----
A
A
-------
E
Y
M
F
D
H
N
----
I
F
Q
D
N
L
V
-
G
V
D
F
----
C
E
Q
MVRETNPGVWEKAKTAEAPHAAEHGYRTIADIMTALN
P
FTGE------------------------------------------------------------------
F
----------------------------------------------------------------------
Y
----------------------------------------------------------------------
R
-
E
T
L
L
V
S
R
-
Y
T
R
E
-------------
M
F
C
------
L
-----
M
E
-----
G
R
H
V
H
P
S
T
L
Y
P
------------------
G
G
V
G
---------------
T
V
-----------
P
--
T
-----------
I
Q
------
L
F----
T
D
YITR
L
M
K
Y
V
E
F
M
--
K
K
V
-
V
-------------
P
LHDD
L
FDFFYEALPGYEEVGRRRIL
L
G
---------------
C
------------
W
------------------
G
---------------
S
--------
F
QDPNVCDYNYRTMTK
W
GR------
G
M
F
V
T
P
------------------
G
V
V
V
--
D
GELLT
T
---------------------------------------------
D
LVDINLNIRILLGSSF
Y
----
Q
DWDHEETSVKNDPLGNAVDRKHPWNQTTLPRPQKRNFGGNYTWVMSPRWL
D
KRTGDHLAL-
D
---------------
T
G
G
G
---
P
I
A
-
R
-------------
L
-------------
W
A
----
T
----
A
L
-----
A
-------------------------------------------
G
L
---------------------------------------------
V
-----------------------------------------------
D
--------------------------------------------
I
---------
G
--
Y
I
K
S
T
G
HSVKIYLPRTAL
K
--------------------------
P
EAEFE
W
------
K
----------------
I
-----------------------------
P
M
W
S
-
N
A
I
E
R
D
R
A
R
T
-------------------
Y
F
Q
A
Y
S
A
AAAL
Y
F
A
------------
E
Q
A
L
A
-
E
L
H
A
G
-
R
--------
T
-----------
R
----
T
------
F
--------
T
D
---
F
--
K
V
----------
P
D
E
A
I
G
C
G
F
H
E
A
V
R
G
V
L
S
H
H
L
------
V
I
R
-
D
G
K
I
A
N
Y
H
P
Y
P
P
---------------------------
T
P
W
N
A
----
S
P
R
DIYGTPGPY
E
---------
D
---------
A
--
V
Q
N
T
-
P
I
F
EENGPEKFKGI
D
------
I
M
R
A
V
R
S
-----------
F
D
P
--
C
L
P
C
G
V
---------------------
52
HHSearch
69.37
19%
-26
- C1 -
5ADU
6
MBHL_ECOLI
L:
[16-581]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
R
L
V
V
D
P
-
I
-
T
R
I
E
G
--------------------------------
H
M
-----
R
C
E
V
--
N
I
N
--
D
-------------------
Q
N
V
I
T
-
N
A
V
S
C
G
T
M
F
R
G
--
L
E
I
I
L
-----
Q
G
R
D
--
P
R
D
A
W
-
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
---
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
-----------
I
-
I
R
N
I
M
L
----
A
T
-------
L
W
C
H
N
H
L
----
V
H
F
Y
Q
L
A
G
M
-
D
W
----
I
D
V
-------------------------------------
L
DALKADPRKTSELAQSLSSWPKSSPGYFFDVQNRLKKFVEGGQLGIFRNGYWGHPQYKLPPEANLMGFA-
H
----------------------------------------------------------------------
Y
----------------------------------------------------------------------
L
-
E
A
L
D
F
Q
R
-
E
I
V
K
-------------
I
H
A
------
V
-----
F
G
-----
G
K
N
P
H
P
N
-
W
I
V
------------------
G
G
M
P
---------------
C
A
-----------
I
--
N
IDESGAVGAVN
M
E
------
R
L----
N
L
----
V
Q
S
I
I
T
R
T
--
A
D
F
I
N
-------------
N
----
V
--------------------
M
I
---------------
P
------------
D
ALAIGQFN----------
K
PWSEIGTG-------
L
--------
S
---------------
D
--------
K
C
V
L
S
Y
------------------
G
A
F
P
--
D
-----
I
---------------------------------------------
A
----------------
N
----
D
FGEK----------------------------------------------
S
----------
L
L--------------
M
P
G
G
---
A
V
I
-
N
GDFNNVLPVDLVD
P
-------------
Q
Q
----
V
----
Q
E
-----
F
-------------------------------------------
V
D
---------------------------------------------
H
-----------------------------------------------
A
WYRYPNDQVGRHPFDGITDPWYNPGDVKGSDTNIQQLNEQERYS
W
IKAPRWRGN
A
ME
V
G
-
P
L
A
------------
R
--------------------------
T
L----
I
AYHKGD
A
----------------
A
TVESVDRMMSALNLPL-------------
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
-------------------
H
E
A
Q
W
A
A
----
G
K
L
------------
Q
Y
F
F
D
-
K
L
M
T
N
-
L
--------
K
-----------
N
----
G
NLATAS
T
--------
E
K
--
W
E
PA
T
W
----------
P
T
E
C
R
G
V
G
F
T
E
A
P
R
G
A
L
G
H
W
A
------
A
I
R
-
D
G
K
I
D
L
Y
Q
C
V
V
P
---------------------------
T
T
W
N
A
----
S
P
R
DPKGQIGAY
E
---------
A
---------
A
--
L
M
N
T
-
K
M
A
IPEQPL-----
E
------
I
L
R
T
L
H
S
-----------
F
N
P
--
C
L
A
C
S
T
---------------------
36
Fugue
69.31
21%
-54
- C1 -
4XHJ
7
GH_VZVO
A:
[36-791]
--------------------------------------------------------------
A
L
L
R
E
Y
S
---
D
R
N
M
S
L
--
K
L
E
A
F
Y
P
T
----
G
-
F
D
E
E
L
-
I
K
S
LHWGNDRK
H
V
F
L
V
I
V
K
V
NPTT
H
E
-
G
D
----
V
----
G
L
V
I
F
P
K
Y
L
L
S
-
P
Y
R
F
G
F
L
---
S
H
P
V
T
P
D
V
S
F
F
D
S
SF
A
-----------
P
Y
L
T
TQHLVAFT
T
F
P
---
P
----
N
P
L
V
---------------
W
H
L
E
R
A
ETAATAERP
F
G
V
S
L
L
P
A
R
-
P
T
V
-
P
K
N
T
I
L
E
H
K
A
H
F
A
T
W
D
A
L
A
R
H
T
F
F
S
A
E
A
I
I
T
N
S
T
L
R
I
H
V
P
L
FGSV
W
P
I
R
Y
W
A
T
G
S
V
L
L
T
S
D
S
G
R
V
E
V
N
I
G
V
G
F
M
S
S
L
I
S
L
SS
G
L
P
I
E
L
I
V
V
PHT
V
K
L
N
A
V
T
SDTTWF
Q
L
N
P
P
G
PDPGP
S
Y
R
V
--
Y
L
L
--
G
RGLDMNFSKHA
T
V
D
I
C
A
YP
E
E
S
L
D
-
Y
R
Y
H
L
S
M
A
H
T
E
--
A
L
R
M
T
T
K
ADQ
H
D
I
N
--
E
E
S
Y
Y
-
H
I
A
A
R
I
A
T
S
I
F
A
L
S
E
M
G
R
T
T
EY
F
L
L
D
E
I
V
D
V
Q
Y
Q
L
K
F
L
-----------
N
-
Y
I
L
M
R
I
GAGA
H
P
-------
N
T
I
S
G
T
S
D
L
IF
A
D
P
S
Q
L
H
-
D
-
E
L
----
S
L
L
-------------------------------------
F
----------------------------------------------------------------------
G
----------------------------------------------------------------------
Q
----------------------------------------------------------------------
F
I
S
Y
D
E
A
R
D
-
Q
L
K
T
-------------
A
Y
A
L
SRGQD
H
-----
V
N
-----
A
L
S
L
A
R
R
V
I
M
S
------------------
I
Y
K
G
---------------
L
L
-----------
V
--
K
-----------
Q
N
------
L
-----
N
A
----
T
E
R
Q
A
L
F
F
--
A
S
M
-
I
L
L
NFS
S
R
V
L
D
G
R
T
T
----
L
--------------------
L
L
---------------
M
------------
T
------------------
S
---------------
M
--------
C
---------------
T
--------
A
A
H
A
T
Q
------------------
A
A
L
N
--
I
-----
Q
---------------------------------------------
E
----------------
G
----
L
--------------------------------------------------
A
----------
Y
LNPSK
H
M
F
T
IPNVYS
P
C
M
G
------------------------------------
S
----
L
----
R
T
-----
D
-------------------------------------------
L
T
---------------------------------------------------------------------------------------------
E
--------------------------------------------
E
---------
I
--
H
V
-
M
N
L
------------
L
--------------------------
S
-----
A
------
I
----------------
P
-----------------------------
T
R
P
G
-
L
N
E
V
L
H
T
Q
L
D
-------------------
E
S
E
I
F
D
A
----
A
F
K
T
M
M
I
F
T
T
WTAKD
L
H
I
L
H
-
T
H
V
-
P
-
E
--------
V
FTCQDAAARNG
E
----
Y
------
V
--------
L
I
--
L
P
--
A
V
----------
Q
G
H
S
Y
V
I
T
R
N
K
P
Q
R
G
L
V
Y
S
L
A
------
D
V
D
V
Y
N
P
I
S
V
V
Y
L
S
K
D
TC
V
S
E
H
G
V
I
E
T
V
A
L
P
HPDNLKECLYCG
S
V
F
L
R
----
Y
L
T
---------
T
---------
G
---------
A
--
I
M
D
I
-
I
I
I
-----------
D
------
S
K
D
T
E
R
Q
L
A
AMGNSTIPP
F
N
P
--
D
M
H
G
D
D
S
K
A
V
L
L
F
PNG
T
V
V
T
L
L
G----
37
Fugue
68.30
15%
-65
- C1 -
4PO6
4
TYK2_HUMAN
A:
[6-546]
----------------------------------------------G
G
L
K
V
L
L
H
--------
W
A
G
P
G
G
G
---
E
P
W
V
T
F
--
S
E
S
S
L
T
A
E
----
E
-
V
C
I
H
I
-
A
H
K
---------------------
V
G
I
T
P
----
P
----
C
F
N
L
F
A
L
F
D
A
Q
A
Q
V
W
L
P
P
N
---
H
I
L
E
I
P
R
D
A
S
L
M
-----------------
L
---------
Y
F
R
---
I
----
R
F
Y
F
---------------
R
N
W
H
--------------
G
M
--------
N
P
R
E
P
A
V
Y
R
C
G
-----------
P
P
G
Q
G
M
Q
L
L
D
P
A
S
F
E
Y
-------------------
L
F
E
Q
G
K
H
E
F
V
N
D
V
A
S
-
L
W
E
L
S
T
E
--------------------------------
E
E
-----
I
H
H
F
--
K
N
E
--
S
-------------------
L
G
M
A
F
-
L
H
L
C
H
L
A
L
R
H
G
IP
L
E
E
V
A
-----
K
K
T
S
--
F
K
D
C
I
P
R
S
F
R
R
H
I
R
Q
H
S
A
L
T
R
L
R
L
R
---
N
V
F
R
R
F
L
R
D
F
Q
P
G
R
L
S
-----------
Q
-
Q
M
V
M
V
K
----
Y
L
-------
A
T
L
E
R
L
A
----
P
R
F
G
T
E
R
-
V
-
P
V
----
C
H
L
-------------------------------------
R
----------------------------------------------------------------------
L
----------------------------------------------------------------------
L
----------------------------------------------------------------------
A
-
Q
A
E
G
--
E
-
P
C
Y
I
-------------
R
D
A
------
G
-----
P
P
-----
T
H
E
V
L
V
T
G
--
T
------------------
G
G
I
Q
---------------
W
W
-----------
P
----------------------
V
-----
E
P
----
L
W
A
Y
F
C
D
F
--
R
D
I
-
T
-------------
H
----
V
--------------------
V
L
K
--------------
E
------------
H
------------------
C
---------------
V
--------
S
---------------
I
--------
H
R
Q
D
N
K
------------------
C
L
E
L
S
L
P
-----
S
---------------------------------------------
R
----------------
A
----
A
--------------------------------------------------
A
----------
L
---------------
S
F
V
S
---
L
V
D
-
G
-------------
Y
-------------
F
R
----
L
----
T
A
-----
D
-------------------------------------------
S
S
---------------------------------------------
H
-----------------------------------------------
Y
--------------------------------------------
L
---------
C
--
H
E
-
V
A
P
------------
P
--------------------------
R
-----
L
------
V
----------------
M
-----------------------------
S
I
R
D
-
G
I
H
G
P
L
L
E
P
F
-------------------
V
Q
A
K
L
R
P
----
E
D
G
------------
L
Y
L
I
H
W
S
T
S
-
H
-
P
--------
Y
-----------
R
----
L
------
I
--------
L
T
--
V
A
--
Q
R
----------
S
Q
A
P
D
G
M
Q
S
L
R
L
R
K
F
P
I
E
Q
A
F
------
V
L
E
G
W
G
R
------------------------------------
S
F
P
S
V
----
R
E
L
---------
G
---------
A
---------
A
--
L
Q
G
C
-
L
L
R
-----------
A
GD
D
C
--
F
S
L
R
R
C
C
-----------
L
P
Q
--
P
G
E
T
S
N
L
I
I
M
R
G---------------
35
Fugue
58.09
14%
-36
* C1 *
1H2A
4
PHNL_DESVM
L:
[19-552]
--------------------------------------------------
S
-----------
S
Y
S
G
P
I
V
---
V
D
P
V
T
R
--
I
E
G
H
-------------
L
R
-
I
E
V
---------------------
E
V
-
E
N
----
G
----
K
V
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
---
K
G
R
D
P
R
D
A
Q
H
F
T
Q
--
R
-----------
T
C
G
---------
V
C
T
YTH
A
----
L
A
S
T
---------------
R
C
V
D
--------------
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
-
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
-------------------
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
-
R
K
--
T
T
A
--------------------------------
A
D
-----
L
K
A
V
--
Q
D
K
--
L
-------------------
K
T
F
V
E
-
T
G
Q
L
G
P
F
T
N
------
A
Y
F
-----
L
G
G
H
--
P
A
Y
Y
L
-
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
---
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
TQFTVVGGVTC
Y
-
D
A
L
T
P
Q
----
R
I
-------
A
E
F
E
A
L
W
----
K
E
T
K
A
F
V
-
D
-
E
V
----
Y
I
P
-------------------------------------
D
----------------------------------------------------------------------
L
----------------------------------------------------------------------
L
----------------------------------------------------------------------
V
-
V
A
A
A
Y
K
D
-
W
T
Q
Y
GGTDNFITFGEFP
K
D
E
------
Y
-----
D
---------
L
N
S
R
F
F
K
P
------------------
G
V
V
F
---------------
K
R
-----------
D
--
F
-----------
K
N
------
I
-----
K
P
----
F
D
K
M
Q
I
E
E
--
H
V
R
-
H
-------------
S
----
W
--------------------
Y
E
----------------------------
G
------------------
A
---------------
E
--------
A
---------------
R
--------
H
P
W
K
G
Q
TQPKYTDLHGDDRYSWMK
A
P
R
Y
--
M
-----
G
---------------------------------------------
E
----------------
P
----
M
--------------------------------------------------
E
----------
T
---------------
G
P
L
A
---
Q
V
L
-
I
-------------
A
-------------
Y
S
----
Q
----
G
H
-----
P
-------------------------------------------
K
V
---------------------------------------------
K
-----------------------------------------------
A
--------------------------------------------
V
---------
T
--
D
A
-
V
L
A
------------
K
--------------------------
L
-----
G
------
V
----------------
G
-----------------------------
P
E
A
L
F
S
T
L
G
R
T
A
A
R
G
-------------------
I
E
T
A
V
I
A
----
E
Y
V
------------
G
V
M
L
Q
-
E
Y
K
-
D
-
N
--------
I
-----------
A
KGDN
V
------
I
--------
C
A
--
P
W
--
E
M
----------
P
K
Q
A
E
G
V
G
F
V
N
A
P
R
G
G
L
S
H
W
I
------
R
I
E
-
D
G
K
I
G
N
F
Q
L
V
V
P
---------------------------
S
T
W
T
L
GPRC
D
K
N
---------
N
---------
V
---------
S
--
P
V
E
A
-
S
L
I
-----------
G
------
T
P
V
A
D
A
K
RPVE-------
I
L
R
--
T
V
H
S
F
D
P
CIACGVH-------------
34
Fugue
57.59
18%
-63
- C1 -
3WAI
-
MALE_ECOLI
A:
[-1-868]
M
K
I
E
EG
K
L
V
I
W
I
N
GDKG
Y
N
G
L
A
E
V
G
K
K
F
E
K
D
TG
I
K
V
T
V
E
H
P
DK
L
E
E
K
F
P
Q
V
A
A
T
GDGPD
I
I
F
W
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
A
E
I
T
P
D
K
A
F
Q
D
----
K
L
Y
P
F
T
W
-
D
A
V
---------------------
R
Y
-
N
G
----
K
LI
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
PKT
W
E
E
I
P
A
L
D
K
E
L
K
A
--
K
GKSA
L
M
F
NLQE
P
Y
F
---------
T
W
P
---
L
I
A
AD
G
G
Y
A
FKDVGVDN
A
G
A
K
A
G
L
T
F
L
V
--------------
D
L
I
K
N
K
-
H
M
N
A
D
T
D
Y
S
I
A
E
A
A
F
N
K
G
E
T
A
M
-
T
I
N
G
P
W
A
W
S
N
I
D
T
S
K
V
N
Y
-------------------
G
V
T
V
L
P
T
F
K
G
Q
P
S
K
P
--
F
V
G
V
L
S
--------------------------------
A
G
-----
I
N
A
A
--
S
P
N
--
K
-------------------
E
L
A
K
E
-
F
L
E
N
Y
L
L
T
D
E
G
--
L
E
A
V
N
-----
K
D
K
P
LG
A
V
A
L
K
-
S
Y
E
E
E
L
A
K
D
P
R
I
A
A
T
M
E
N
A
---
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
-----------
Y
A
V
R
T
A
V
I
----
N
A
A
S
GRQT
V
D
E
A
L
K
D
A
----
Q
T
N
K
Q
W
Y
-
D
-
A
L
----
T
W
M
-------------------------------------
R
----------------------------------------------------------------------
E
----------------------------------------------------------------------
N
----------------------------------------------------------------------
T
-
P
D
G
E
K
Y
D
-
E
Y
P
F
-------------
E
T
Y
------
G
-----
V
I
S
WWDY
G
H
W
I
E
A
V
A
H
R
M
PIANPFQAGIGNKYNNVP
G
A
S
S
---------------
F
F
-----------
T
--
A
-----------
E
N
------
E
-----
S
Y
----
A
E
F
V
A
E
K
L
NV
K
Y
V
-
V
-------------
S
----
D
--------------------
I
E
---------------
M
------------
E
------------------
T
---------------
G
--------
K
---------------
Y
--------
Y
A
M
A
V
W
------------------
A
E
G
D
--
L
-----
P
---------------------------------------------
L
----------------
A
----
E
--------------------------------------------------
K
----------
Y
---------------
Y
G
G
Y
---
F
Y
Y
-
S
-------------
P
-------------
T
G
T
F
G
Y
A
----
N
S
-----
Q
-------------------------------------------
W
D
---------------------------------------------
I
-----------------------------------------------
P
--------------------------------------------
L
---------
N
--
S
I
-
I
I
P
------------
L
R
I
P
S
E
L
Y
Y
S
T
M
E
--------------
A
-----
K
------
L
----------------
H
-----------------------------
L
F
D
G
-
S
G
L
S
H
Y
R
M
I
Y
ESDYP
A
E
W
K
S
Y
S
S
Q
VNLNN
E
S
Q
V
L
Q
T
----
A
L
Y
------------
E
A
V
M
R
-
A
R
Y
-
G
-
V
SPT
M
G
T
Q
E
V
-----------
L
----
Y
------
K
--------
Y
A
--
Y
T
--
Q
L
YEKKMG
I
P
V
K
I
A
P
S
G
Y
V
K
I
F
E
R
V
K
G
A
V
V
T
G
K
V
SANVT
E
V
S
V
N
A
T
I
K
T
N
Q
--
N
R
---------------------------
T
F
E
Y
W
----
Q
T
V
---------
E
---------
V
---------
K
NG
T
Y
T
V
-
V
L
P
YSHNS------
D
------
Y
P
V
K
P
I
T
-----------
P
Y
H
--
I
K
A
G
N
V
V
K
E
I
T
I
Y
E
S
Q
V
Q
N
G
E
I
I
Q
L
D
L
55
HHSearch
51.31
27%
-86
- C1 -
3MCR
2
?
A:
[106-212]
----------------------------------------------------
R
G
--------
E
I
T
F
H
V
Q
---
R
E
H
L
L
D
--
V
A
T
-
R
L
R
D
DPAL
R
-
F
E
L
C
L
G
V
T
G
---------------------
V
H
-
Y
P
EDEG
N
----
E
L
H
A
V
Y
A
L
R
S
I
T
H
N
Y
E
I
R
L
---
E
V
S
C
P
D
S
D
P
H
I
P
S
--
I
-----------
V
S
V
---------
Y
P
T
---
N
----
D
W
H
E
---------------
R
E
A
W
--------------
D
F
F
G
I
I
-
F
D
G
H
P
A
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
45.14
29%
-42
- C1 -
5A4M
3
MBHL_ECOLI
L:
[29-127]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
H
M
R
C
EV
N
I
N
--
D
-------------------
Q
N
V
I
T
-
N
A
V
S
C
G
T
M
F
R
G
--
L
E
I
I
L
-----
Q
G
R
D
--
P
R
D
A
W
-
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
---
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
-----------
I
-
I
R
N
I
M
L
----
A
T
-------
L
W
C
H
D
H
L
----
V
H
F
Y
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
44.92
30%
-41
- C1 -
3AYY
11
?
A:
[29-119]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
H
M
R
C
E
V
N
V
D
--
E
-------------------
N
N
V
I
Q
-
N
A
V
S
T
G
T
M
W
R
G
--
L
E
V
I
L
-----
R
G
R
D
--
P
R
D
A
W
-
A
F
V
E
R
I
C
G
V
C
T
G
C
H
A
L
A
S
V
---
R
A
V
E
D
A
L
D
I
K
I
P
H
N
A
T
-----------
L
-
I
R
E
I
M
A
----
K
T
-------
L
Q
I
H
D
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
44.90
29%
-42
- C1 -
4UE3
3
MBHL_ECOLI
L:
[29-127]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
H
M
R
C
EV
N
I
N
--
D
-------------------
Q
N
V
I
T
-
N
A
V
S
C
G
T
M
F
R
G
--
L
E
I
I
L
-----
Q
G
R
D
--
P
R
D
A
W
-
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
---
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
-----------
I
-
I
R
N
I
M
L
----
A
T
-------
L
W
C
H
D
H
L
----
V
H
F
Y
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
44.84
31%
-43
- C1 -
5D51
7
?
L:
[28-121]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
H
M
R
C
EV
N
V
D
--
A
-------------------
N
N
V
I
R
-
N
A
V
S
T
G
T
M
W
R
G
--
L
E
V
I
L
-----
K
G
R
D
--
P
R
D
A
W
-
A
F
V
E
R
I
C
G
V
C
T
G
C
H
A
L
A
S
V
---
R
A
V
E
N
A
L
D
I
R
I
P
K
N
A
H
-----------
L
-
I
R
E
I
M
A
----
K
T
-------
L
Q
V
H
D
H
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------