@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0092: (2016-04-19 )
MTTAVTGEHHASVQRIQLRISGMSCSACAHRVESTLNKLPGVRAAVNFGTRVATIDTSEAVDAAALCQAVRRAGYQADLCTDDGRSASDPDADHARQLLIRLAIAAVLFVPVADLSVMFGVVPATRFTGWQWVLSALALPVVTWAAWPFHRVAMRNARHHAASMETLISVGITAATIWSLYTVFGNHSPIERSGIWQALLGSDAIYFEVAAGVTVFVLVGRYFEARAKSQAGSALRALAALSAKEVAVLLPDGSEMVIPADELKEQQRFVVRPGQIVAADGLAVDGSAAVDMSAMTGEAKPTRVRPGGQVIGGTTVLDGRLIVEAAAVGADTQFAGMVRLVEQAQAQKADAQRLADRISSVFVPAVLVIAALTAAGWLIAGGQPDRAVSAALAVLVIACPCALGLATPTAMMVASGRGAQLGIFLKGYKSLEATRAVDTVVFDKTGTLTTGRLQVSAVTAAPGWEADQVLALAATVEAASEHSVALAIAAATTRRDAVTDFRAIPGRGVSGTVSGRAVRVGKPSWIGSSSCHPNMRAARRHAESLGETAVFVEVDGEPCGVIAVADAVKDSARDAVAALADRGLRTMLLTGDNPESAAAVATRVGIDEVIADILPEGKVDVIEQLRDRGHVVAMVGDGINDGPALARADLGMAIGRGTDVAIGAADIILVRDHLDVVPLALDLARATMRTVKLNMVWAFGYNIAAIPVAAAGLLNPLVAGAAMAFSSFFVVSNSLRLRKFGRYPLGCGTVGGPQMTAPSSA
Atome Classification :
(32 SA)
.........10........20........30........40.....-....50....--....60.........70........80........90........100.......110......-.120.......130.......140....-...150.......160.-.......170.......180..-.....190.......200.......210.......220.......230.......240.......250.......260.......270.......280.....-..290.......300.....----------..----------310.......320.......330.......340.......350.......360.......370-.--------......-380...--..-...390.......400.......410.......420.......430.......440.......450......-------------------.460--....-------------------....-470.....-.----------------.------------------480.......490-----....-----------.----.----..500-------.....-------------------------...--510.------..--....520.........530-.-----------.----.....540---------....---....550-....------------------------....---------------------.560.......570.......580.......590.......600....-----------------------------------------------------.------------------------------.-----------------------------------------------------.610.......620.......630.......640.......650...-....660.......670.......680.......690.......700.......710-----..-------.....--------..720.......730.......740.......750.......760----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
T
A
VTGEHHA
S
V
Q
R
I
Q
L
R
ISGM
S
C
S
A
C
A
H
R
V
E
S
T
L
N
KLP-GV
R
A
A
-
V
NFG
T
R
V
A
T
I--D
T
S
EA-V
D
A
A
A
L
C
Q
A
V
R
RAGYQADLCTDDGRSASDP
D
A
D
H
A
R
Q
L
L
I
R
L
A
I
A
A
V
L
F
VPV
A
D
L
S
V
M
-
F
GVVPATRF
T
G
W
Q
W
V
L
S
A
L
A
L
P
V
V
T
WAA-W
P
F
H
R
V
A
M
R
NA
R
H
H
-
A
A
-
S
M
E
T
L
I
S
V
G
I
T
A
A
T
I
W
S
L
Y
T
V
F-GNHSPIERS
G
I
W
Q
A
L
LGS
D
A
I
Y
F
E
VAA
G
V
T
V
F
V
L
V
G
R
Y
F
E
A
R
AKSQ
A
G
S
A
L
R
A
L
A
A
LSAK
E
V
A
V
LLPDG
S
E
M
V
I
P
A
D
E
L
K
E
Q
Q
R
F
V
VRPG
Q
I
V
A
AD
G
L
A
VDGS-A
A
V
D
M
SAMTGEAKPTRVRPG----------
G
Q
----------
V
IG
G
T
T
V
LD
G
R
L
I
V
E
A
AAVGAD
T
Q
F
A
G
M
V
R
L
V
E
Q
A
Q
A
Q
K
A
D
A
Q
R
L
A
D
R
I
S
S
V
F
V
P
A
V
L
V
I
A
A
L
-
T
--------AA
G
W
L
I
-AG-GQP--
D
R
-
A
V
S
A
A
L
A
V
L
V
I
ACPCALGLATP
T
A
M
M
V
ASGRG
A
Q
L
G
I
F
L
K
G
Y
K
SLEATRA
V
D
T
V
V
FDKTG
T
L
T
T
G
R
L
Q
V
S
A
V
-------------------TAA---PGWE-------------------AD
Q
V
-
L
A
L
A
A
T
V
E-A----------------A------------------SEH
S
V
A
L
A
I
A
A
A------TTRR-----------D----A----VTDF--------RAIPG-------------------------RGV--SGTV------SG--
R
A
V
RV--GKPSWIGSSSCH-P-----------
N
----
M
R
A
A
R
R
H
----------
A
E
SL---GE
T
A
V
---
F
V
E
V------------------------DGEP---------------------
C
G
V
I
A
V
A
D
A
V
K
D
S
A
R
D
A
V
A
A
L
A
DRG
L
R
T
M
L
L
TGDNP
E
S
A
A
A
V
A
T
RV
G
I
-----------------------------------------------------
D
------------------------------
E
-----------------------------------------------------
V
I
A
D
ILPEG
K
V
D
V
I
E
Q
L
R
DRG
H
V
V
A
M
VGDGINDGP
A
L
A
R
A
D
L
G
MAIG-RGT
D
V
A
IG
A
A
D
I
I
L
V
RDHLD
V
V
P
L
A
L
D
L
A
R
A
T
M
R
T
V
K
L
N
M
V
W
AFGY
N
I
A
A
I
P
V
A
A
-------
A
G
-------
L
L
N
P
L
--------
V
A
G
A
A
M
A
F
S
S
F
F
V
VSN
S
L
R
L
R
KFGRYPLGCGTVGGPQMTAPSSA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.79
36%
-99
- C2 -
3J09
-
COPA_ARCFU
A:
[20-728]
-----------------
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
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-
G
V
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V
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V
N
L
A
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F
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--
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----
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A
A
V
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V
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H
L
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R
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A
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L
L
L
F
L
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-
H
-
F
I
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L
P
Y
E
D
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-----
V
Q
L
L
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-
S
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A
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V
L
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T
A
-
G
-------------
V
L
P
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Y
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L
V
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-
A
--------
F
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Y
W
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F
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--
L
L
F
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F
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K
G
K
P
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V
T
D
L
-------------------
V
P
L
---
N
G
D
E
--------------------
R
E
L
-
L
R
L
A
A
I
A
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-
R
----------------
R
------------------
S
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H
P
I
A
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A
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K
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------
A
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G
I
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-------
G
----
E
----
P
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K
V
--------
E
V
I
A
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-------------------------
E
G
V
V
A
D
G
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L
------
V
G
--
N
K
-
R
L
--
M
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D
F
G
V
A
V
S
N
---------------
E
----
V
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L
A
L
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K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
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S
A
K
P
A
V
Q
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L
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G
M
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G
D
N
W
R
S
A
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A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
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S
G
D
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V
L
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R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
-
A
A
-------
A
G
-------
L
L
Y
P
I
FGVVFR
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
86.43
36%
-98
- C2 -
3J09
-
COPA_ARCFU
A:
[15-733]
------------
P
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
-
V
N
L
A
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T
A
F
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F
D
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K
R
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-
D
F
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-
T
I
K
R
V
I
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D
L
G
Y
G
V
V
D
E
Q
A
A
V
S
----
A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
-
H
-
F
I
S
-----
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
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F
Y
S
G
-
S
S
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K
A
A
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S
A
L
R
R
R
-
T
L
-
N
M
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M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
L
--------------
P
R
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Y
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Y
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L
L
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T
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L
-------------------
V
P
L
---
N
G
-
D
-------------------
E
R
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L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
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P
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A
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A
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K
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------
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L
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H
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I
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L
-------
G
----
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----
P
E
K
V
--------
E
V
I
A
G
-------------------------
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G
V
--
V
A
------------
D
G
I
L
V
--
G
N
K
R
L
M
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F
G
V
A
-
V
-----------
S
N
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--
V
E
L
A
L
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K
----------
L
E
R
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---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
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S
A
K
P
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W
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A
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A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
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D
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L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
-------
G
L
L
Y
P
IFGV
V
F
R
P
E
--------
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
86.30
38%
-109
- C2 -
3RFU
3
?
A:
[74-736]
-----------------------------------------------------------------------------------------------
V
S
P
E
Y
L
D
M
R
R
R
F
W
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A
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M
L
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G
G
H
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L
L
A
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V
L
W
G
G
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W
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W
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G
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A
W
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----
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V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
-
S
--------
F
I
V
W
A
L
-
L
G
-
P
Q
P
AL
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
----
D
D
F
V
-------------------
E
D
N
A
-
L
A
L
A
A
A
L
E
-
H
----------------
Q
------------------
S
E
H
P
L
A
N
A
I
V
H
A
------
A
K
E
K
GL
S
L
-------
G
----
S
----
V
E
A
F
--------
E
A
P
T
G
-------------------------
K
G
V
--
V
G
Q
V
------
D
G
--
H
H
V
A
I
--
G
N
A
R
L
M
Q
E
H
G
G
D
N
A
-----------
P
----
L
F
E
K
A
D
E
----------
L
R
G
K
---
G
A
S
V
M
---
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPLT
G
L
-------
L
L
S
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
---
R
V
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.20
38%
-112
- C2 -
4BYG
4
?
A:
[84-733]
---------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
-
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
-
S
--------
F
I
V
W
A
L
-
L
G
-
P
Q
P
A
L
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
---
D
F
V
E
--------------------
D
N
A
-
L
A
L
A
A
A
L
E
-
H
----------------
Q
------------------
S
E
H
P
L
A
N
A
I
V
H
A
------
A
K
E
K
-----------
G
L
S
L
G
S
----
V
E
A
F
--------
E
A
P
T
G
-------------------------
K
G
V
--
V
G
Q
V
------
D
G
--
H
H
V
A
I
--
G
------------------------
N
----
A
R
L
M
Q
E
H
G
G
D
N
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
---
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.95
38%
-111
- C2 -
3RFU
3
?
A:
[84-733]
---------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
-
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
-
S
--------
F
I
V
W
A
L
-
L
G
-
P
Q
P
AL
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
---
D
F
V
E
--------------------
D
N
A
-
L
A
L
A
A
A
L
E
-
H
----------------
Q
------------------
S
E
H
P
L
A
N
A
I
V
H
A
------
A
K
E
K
-----------
G
L
S
L
G
S
----
V
E
A
F
--------
E
A
P
T
G
-------------------------
K
G
V
--
V
G
Q
V
------
D
G
--
H
H
V
A
I
--
G
------------------------
N
----
A
R
L
M
Q
E
H
G
G
D
N
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
---
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.74
38%
-111
- C2 -
4BEV
2
?
A:
[84-733]
---------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
-
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
-
S
--------
F
I
V
W
A
L
-
L
G
-
P
Q
P
A
L
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
---
D
F
V
E
--------------------
D
N
A
-
L
A
L
A
A
A
L
E
-
H
----------------
Q
------------------
S
E
H
P
L
A
N
A
I
V
H
A
------
A
K
E
K
-----------
G
L
S
L
G
S
----
V
E
A
F
--------
E
A
P
T
G
-------------------------
K
G
V
--
V
G
Q
V
------
D
G
--
H
H
V
A
I
--
G
------------------------
N
----
A
R
L
M
Q
E
H
G
G
D
N
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
---
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.40
38%
-111
- C2 -
3RFU
3
?
C:
[84-733]
---------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
-
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
-
S
--------
F
I
V
W
A
L
-
L
G
-
P
Q
P
AL
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
---
D
F
V
E
--------------------
D
N
A
-
L
A
L
A
A
A
L
E
-
H
----------------
Q
------------------
S
E
H
P
L
A
N
A
I
V
H
A
------
A
K
E
K
-----------
G
LSLG
S
----
V
E
A
F
--------
E
A
P
T
G
-------------------------
K
G
V
--
V
G
Q
V
------
D
G
--
H
H
V
A
I
--
G
------------------------
N
----
A
R
L
M
Q
E
H
GGDNAPLFEK
A
D
E
L
RGK
G
A
S
V
M
---
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
84.21
38%
-111
- C2 -
3RFU
3
?
D:
[84-733]
---------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
-
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
-
S
--------
F
I
V
W
A
L
-
L
G
-
P
Q
P
AL
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
---
D
F
V
E
--------------------
D
N
A
-
L
A
L
A
A
A
L
E
-
H
----------------
Q
------------------
S
E
H
P
L
A
N
A
I
V
H
A
------
A
K
E
K
-----------
G
LSLG
S
----
V
E
A
F
--------
E
A
P
T
G
-------------------------
K
G
V
--
V
G
Q
V
------
D
G
--
H
H
V
A
I
--
G
------------------------
N
----
A
R
L
M
Q
E
H
GGDNAPLFEK
A
D
E
L
RGK
G
A
S
V
M
---
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.08
38%
-111
- C2 -
3RFU
3
?
B:
[84-733]
---------------------------------------------------------------------------------------------------------
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
-
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
-
S
--------
F
I
V
W
A
L
-
L
G
-
P
Q
P
AL
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
---
D
F
V
E
--------------------
D
N
A
-
L
A
L
A
A
A
L
E
-
H
----------------
Q
------------------
S
E
H
P
L
A
N
A
I
V
H
A
------
A
K
E
K
-----------
G
LSLG
S
----
V
E
A
F
--------
E
A
P
T
G
-------------------------
K
G
V
--
V
G
Q
V
------
D
G
--
H
H
V
A
I
--
G
------------------------
N
----
A
R
L
M
Q
E
H
GGDNAPLFEK
A
D
E
L
RGK
G
A
S
V
M
---
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Fugue
77.19
32%
-102
- C2 -
4UMW
2
?
A:
[124-730]
--------------------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
--------------------
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
-
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
-----------------------
I
G
A
----
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
V
-
S
A
L
M
A
L
K
----
P
E
T
A
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
--------
L
V
P
P
L
L
-
F
A
-
A
S
W
--
Q
E
-
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
-------------------
H
P
A
---
T
G
I
S
-------------------
E
S
E
L
-
L
T
L
A
A
A
V
E
-
Q
----------------
G
------------------
A
T
H
P
L
A
Q
A
I
V
R
E
------
A
Q
V
A
-----------
E
----
L
AIPT
A
E
S
Q
--------
R
A
L
V
G
-------------------------
S
G
I
--
E
A
Q
V
------
N
G
--
E
R
V
L
I
--
C
A
A
G
K
H
P
A
D
A
--------------------
F
A
G
L
I
N
E
----------
L
E
S
A
---
G
Q
T
V
V
---
L
V
V
R
------------------------
N
D
D
V
---------------------
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
P
-
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
-------
L
G
-------
M
T
G
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.62
38%
-96
- C2 -
3J08
-
COPA_ARCFU
A:
[126-728]
-----------------------------------------------------------------------------------------------------------------------------------------
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
-
G
-------------
V
L
P
R
E
Y
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
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L
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A
K
-
T
A
V
V
I
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D
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E
V
A
V
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D
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I
V
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G
E
K
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D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
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E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
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L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
-
A
--------
F
I
Y
W
Y
F
-
I
A
-
H
A
P
--
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
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N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-------------------
V
P
L
---
N
G
D
E
--------------------
R
E
L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
S
E
H
P
I
A
E
A
I
V
K
K
------
A
L
E
H
G
I
E
L
-------
G
----
E
----
P
E
K
V
--------
E
V
I
A
G
-------------------------
E
G
V
V
A
D
G
I
L
------
V
G
--
N
K
-
R
L
--
M
E
D
F
G
V
A
V
S
N
---------------
E
----
V
E
L
A
L
E
K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
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R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
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I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
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V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
-
A
A
-------
A
G
-------
L
L
Y
P
I
FGVVFR
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
76.06
38%
-96
- C2 -
3J08
-
COPA_ARCFU
A:
[124-733]
---------------------------------------------------------------------------------------------------------------------------------------
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
L
--------------
P
R
E
Y
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
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L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
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L
Q
A
K
T
A
V
V
I
R
-
D
G
K
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I
A
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V
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E
V
A
V
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D
I
V
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V
R
P
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E
K
I
P
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V
V
V
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G
E
-
S
Y
V
D
E
S
M
I
S
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E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
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V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
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A
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L
A
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K
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V
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F
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T
V
L
L
V
A
I
S
-
A
--------
F
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W
Y
F
-
I
A
H
A
P
L
--
L
F
-
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
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G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-------------------
V
P
L
---
N
G
-
D
-------------------
E
R
E
L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
S
E
H
P
I
A
E
A
I
V
K
K
------
A
L
E
H
G
I
E
L
-------
G
----
E
----
P
E
K
V
--------
E
V
I
A
G
-------------------------
E
G
V
--
V
A
------------
D
G
I
L
V
--
G
N
K
R
L
M
E
D
F
G
V
A
-
V
-----------
S
N
E
--
V
E
L
A
L
E
K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
-------
G
L
L
Y
P
IFGV
V
F
R
P
E
--------
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.18
30%
-104
- C2 -
4UMW
2
?
A:
[124-730]
--------------------------------------------------------------------------------------------------
R
L
K
E
N
L
-----------
P
L
I
T
L
I
V
M
-
M
A
I
--
S
W
G
L
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
-
S
Y
F
A
I
E
T
L
M
S
V
----
A
A
I
G
A
L
F
-------------------
I
G
A
T
A
----
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
-
P
E
T
A
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
-
V
T
L
VPPLLF
A
A
S
W
-----------
Q
E
-
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
-------------------
H
P
A
---
T
G
I
S
-------------------
E
S
E
L
-
L
T
L
A
A
A
V
E
-
Q
----------------
G
------------------
A
T
H
P
L
A
Q
A
I
----------
V
R
E
-----------
A
----
Q
----
V
A
E
L
AIPTAESQ
R
A
L
V
G
-------------------------
S
G
I
--
E
A
Q
V
------
N
G
--
E
R
V
--------
L
I
C
A
A
G
K
H
-
P
AD---------
A
----
F
A
G
L
I
N
E
----------
L
E
S
A
---
G
Q
T
V
V
---
L
V
V
R
------------------------
N
D
D
V
---------------------
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
P
-
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
-------
L
G
-------
M
T
G
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
74.43
30%
-103
- C2 -
4UMW
2
?
A:
[124-730]
-----------------------------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
I
T
L
--
I
V
M
M
A
I
S
-
W
-
G
L
E
Q
---
F
N
H
P
F
G
Q
L
A
F
I
---
A
T
T
L
V
G
L
-
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
-
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
---------------------------
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
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I
L
K
L
I
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E
A
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E
R
R
A
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F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
-
V
--------
T
L
V
P
P
L
L
F
A
-
A
S
W
--
Q
E
-
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
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R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
-------------------
H
P
A
---
T
G
I
S
-------------------
E
S
E
L
-
L
T
L
A
A
A
V
E
-
Q
----------------
G
------------------
A
T
H
P
L
A
Q
A
I
V
R
E
------
A
Q
V
A
ELAI-------
P
----
T
----
A
E
S
Q
--------
R
A
L
V
G
-------------------------
S
G
I
--
E
A
Q
V
------
N
G
--
E
R
V
L
I
--
C
A
A
G
K
H
P
A
D
A
--------------------
F
A
G
L
I
N
E
----------
L
E
S
A
---
G
Q
T
V
V
---
L
V
V
R
------------------------
N
D
D
V
---------------------
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------
E
------------------------------------------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
-------
L
G
-------
M
T
G
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.00
30%
-97
- C2 -
4UMV
2
?
A:
[126-730]
----------------------------------------------------------------------------------------------------
K
E
N
L
-----------
P
L
I
T
L
I
V
M
-
M
A
I
--
S
W
G
L
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
-
S
Y
F
A
I
E
T
L
M
S
V
----
A
A
I
G
A
L
F
-------------------
I
G
A
T
A
----
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
-
P
E
T
A
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
-
V
T
L
V
P
P
L
LF
A
A
S
W
-----------
Q
E
-
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
-------------------
H
P
A
---
T
G
I
S
-------------------
E
S
E
L
-
L
T
L
A
A
A
V
E
-
Q
----------------
G
------------------
A
T
H
P
L
A
Q
A
I
----------
V
R
E
-----------
A
----
Q
----
V
A
E
L
A
I
P
T
A
E
S
Q
R
A
L
V
G
-------------------------
S
G
I
--
E
A
Q
V
------
N
G
--
E
R
V
--------
L
I
C
A
A
G
K
H
-
P
AD---------
A
----
F
A
G
L
I
N
E
----------
L
E
S
A
---
G
Q
T
V
V
---
L
V
V
R
------------------------
N
D
D
V
---------------------
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
P
-
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
-------
L
G
-------
M
T
G
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
63.43
19%
-80
- C2 -
3B8E
6
AT1A1_PIG
A:
[1-998]
------
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
-------------------
T
--
D
L
S
R
G
-
L
T
P
A
R
A
A
E
I
L
A
R
D
G
-
P
N
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
R
Q
L
F
G
G
F
S
M
L
L
W
I
G
A
I
L
C
F
L
A
-------------------------------------------------------------------------------
Y
G
I
Q
A
A
T
E
E
E
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
----
I
M
E
S
F
K
N
M
V
P
Q
Q
-
A
L
V
I
R
N
G
E
K
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
----------
F
T
N
ENPLETRNI
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
-
F
--------
F
I
L
S
L
I
-
L
E
-
Y
T
W
--
L
E
-
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
WSDN
Q
I
H
E
A
DTTENQSGVS
F
D
K
---
T
S
A
T
-------------------
W
L
A
L
-
S
R
I
A
G
L
C
N
-
R
----------------
A
V
F
Q
A
NQENLPILK
R
A
V
A
G
D
A
S
E
S
A
L
L
K
C
I
E
L
CCGS
V
K
E
M
R
-----------
E
----
R
----
Y
T
K
I
--------
V
E
I
P
F
NSTN
K
Y
Q
L
S
I
H
K
N
PNTAEPR
H
L
L
V
M
K
G
A
--
P
E
R
I
------
L
D
--
R
C
S
S
I
L
I
H
G
K
E
Q
P
L
D
E
E
L
K
-
D
-----------
A
----
F
Q
N
A
Y
L
E
----------
L
G
G
L
---
G
E
R
V
L
G
F
C
H
L
F
L
------------------------
P
D
E
Q
FPEGF
Q
F
D
T
DDVNFPLDN
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
MT
S
E
Q
L
D
D
I
L
K
YHT
E
------------------------------
I
-----------------------------------------------------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
-------
I
F
-------
I
I
A
------------
N
I
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
PKTDKLVN
E
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
48
HHSearch
61.61
23%
-84
- C2 -
2ZXE
5
?
A:
[138-794]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
-
D
G
E
K
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
FSSENPLETR
N
I
----------
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
-
F
--------
F
I
L
S
L
I
-
L
G
-
Y
S
W
--
L
E
-
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
-------------------
W
F
D
---
N
Q
I
H
E
A
DTTENQSGAAFDKTS
A
T
W
S
A
L
-
S
R
I
A
A
L
C
N
-
R
A
V
F
Q
A
GQDNVPILKRS
V
------------------
A
G
D
A
S
E
S
A
L
L
K
C
------
I
E
L
C
CGS
V
Q
G
M
R
D
R
N
P
----
K
I
V
--
E
I
P
F
--------
N
S
T
N
--------------------------
K
Y
Q
--
L
S
I
H
ENEKSS
E
S
R
Y
L
L
V
M
K
--
G
A
P
E
R
I
L
D
R
C
S
T
-
I
LLNG
A
E
E
P
LK
E
D
M
K
E
A
F
Q
N
A
Y
L
E
----------
L
G
G
L
---
G
E
R
V
L
---
G
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPTT
D
L
C
F
---------------------
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
-----------------------------------------------------
I
------------------------------
S
EGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
57.54
26%
-75
- C2 -
3B8C
2
PMA2_ARATH
A:
[104-658]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
N
S
T
I
S
F
I
E
E
N
N
A
G
N
A
A
A
A
L
M
A
G
L
A
P
K
T
K
V
L
R
-
D
G
K
W
S
E
Q
E
A
A
I
L
V
P
G
D
I
V
S
I
K
L
G
D
I
I
P
A
D
A
R
L
L
E
G
D
P
L
K
V
D
Q
S
A
L
T
G
E
S
L
P
V
T
K
H
P
G
----------
Q
E
----------
V
F
S
G
S
T
C
K
Q
G
E
I
E
A
V
V
I
A
T
G
V
H
T
F
F
G
K
A
A
H
L
V
D
S
T
N
-
Q
V
G
H
F
Q
K
V
L
T
A
I
G
N
F
C
I
C
S
I
A
I
G
M
V
I
-
E
--------
I
I
V
M
Y
P
I
Q
R
-
R
K
Y
--
R
D
-
G
I
D
N
L
L
V
L
L
I
G
G
I
P
I
A
M
P
T
V
L
S
V
T
M
A
I
G
S
H
R
L
S
Q
Q
G
A
I
T
K
R
M
T
A
I
E
E
M
A
G
M
D
V
L
C
S
D
K
T
G
T
L
T
L
N
K
L
S
V
D
K
N
-------------------
L
V
E
VFC
K
G
V
E
-------------------
K
D
Q
V
-
L
L
F
A
A
M
A
S
R
V
----------------
E
------------------
N
Q
D
A
I
D
A
A
M
V
G
M
------
L
A
D
P
KEARAGIRE--
V
----
H
----
F
L
P
F
--------
N
P
V
D
K
-------------------------
R
-
T
--
A
L
T
Y
I
DG---
S
G
N
W
H
R
V
S
K
--
G
A
P
E
Q
I
L
E
L
A
K
A
-
S
ND
L
S
K
------
K
----
V
L
S
I
I
D
K
----------
Y
A
E
R
---
G
L
R
S
L
---
A
V
A
R
Q
VVPEKTKESPG
A
-----------
P
W
E
F
---------------------
V
G
L
L
P
L
F
D
P
P
R
H
D
S
A
E
T
I
R
R
A
L
N
L
G
V
N
V
K
M
I
T
G
D
Q
L
A
I
G
K
E
T
G
R
R
L
G
M
-----------------------------------------------------
G
TNMYPSSALLGTHKDANLASIP
V
E
E
L
I
E
K
A
D
-----------------------------------------------------
G
F
A
G
V
F
P
E
H
K
Y
E
I
V
K
K
L
Q
E
R
K
H
I
V
G
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
D
I
G
I
A
V
A
-
D
A
T
D
A
A
R
G
A
S
D
I
V
L
T
E
P
G
L
S
V
I
I
S
A
V
L
T
S
R
A
I
F
Q
R
M
K
N
Y
T
I
Y
A
V
S
I
T
I
R
I
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
55.10
40%
-83
- C2 -
3A1C
2
?
A:
[14-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-------------------
V
P
L
---
N
G
-
D
-------------------
E
R
E
L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
S
E
H
P
I
A
E
A
I
V
K
K
------
A
L
E
H
G
I
E
L
-------
G
----
E
----
P
E
K
V
--------
E
V
I
A
G
-------------------------
E
G
V
--
V
A
------------
D
G
I
L
V
--
G
N
K
R
L
M
E
D
F
G
V
A
-
V
-----------
S
N
E
--
V
E
L
A
L
E
K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
54.91
39%
-83
- C2 -
3A1D
2
?
B:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-------------------
V
P
L
---
N
G
D
E
-------------------
R
-
E
L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
S
E
H
P
I
A
E
A
I
V
K
K
------
A
L
E
H
-----------
G
IELG
E
----
P
E
K
V
--------
E
V
I
A
G
-------------------------
E
G
V
V
A
D
G
I
L
------
V
G
--
N
K
-
R
L
--
M
E
D
F
G
V
A
V
S
N
---------------
E
----
V
E
L
A
L
E
K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
54.76
39%
-81
- C2 -
3A1E
2
COPA_ARCFU
A:
[14-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-------------------
V
P
L
---
N
G
D
E
-------------------
R
-
E
L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
S
E
Q
P
I
A
E
A
I
V
K
K
------
A
L
E
H
-----------
G
I
E
L
G
E
----
P
E
K
V
--------
E
V
I
A
G
-------------------------
E
G
V
V
A
D
G
I
L
------
V
G
--
N
K
-
R
L
--
M
E
D
F
G
V
A
V
S
N
---------------
E
----
V
E
L
A
L
E
K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
54.69
39%
-85
- C2 -
3A1C
1
?
B:
[14-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-------------------
V
P
L
---
N
G
D
E
-------------------
R
-
E
L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
S
E
H
P
I
A
E
A
I
V
K
K
------
A
L
E
H
-----------
G
IELG
E
----
P
E
K
V
--------
E
V
I
A
G
-------------------------
E
G
V
VA
D
G
I
L
------
V
G
--
N
K
-
R
L
--
M
E
D
F
G
V
A
V
S
N
---------------
E
----
V
E
L
A
L
E
K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.56
39%
-81
- C2 -
3A1C
2
?
A:
[14-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-------------------
V
P
L
---
N
G
D
E
-------------------
R
-
E
L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
S
E
H
P
I
A
E
A
I
V
K
K
------
A
L
E
H
-----------
G
I
E
L
G
E
----
P
E
K
V
--------
E
V
I
A
G
-------------------------
E
G
V
V
A
D
G
I
L
------
V
G
--
N
K
-
R
L
--
M
E
D
F
G
V
A
V
S
N
---------------
E
----
V
E
L
A
L
E
K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
54.38
39%
-80
- C2 -
3A1D
2
?
A:
[14-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-------------------
V
P
L
---
N
G
D
E
-------------------
R
-
E
L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
S
E
H
P
I
A
E
A
I
V
K
K
------
A
L
E
H
-----------
G
I
E
L
G
E
----
P
E
K
V
--------
E
V
I
A
G
-------------------------
E
G
V
V
A
D
G
I
L
------
V
G
--
N
K
-
R
L
--
M
E
D
F
G
V
A
V
S
N
---------------
E
----
V
E
L
A
L
E
K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
54.30
39%
-82
- C2 -
3A1E
1
B:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-------------------
V
P
L
---
N
G
D
E
-------------------
R
-
E
L
-
L
R
L
A
A
I
A
E
-
R
----------------
R
------------------
S
E
Q
P
I
A
E
A
I
V
K
K
------
A
L
E
H
-----------
G
IELG
E
----
P
E
K
V
--------
E
V
I
A
G
-------------------------
E
G
V
V
A
D
G
I
L
------
V
G
--
N
K
-
R
L
--
M
E
D
F
G
V
A
V
S
N
---------------
E
----
V
E
L
A
L
E
K
----------
L
E
R
E
---
A
K
T
A
V
---
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
48.46
33%
-67
- C2 -
2YJ4
2
?
A:
[13-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
---
T
P
I
V
-------------------
T
Q
F
---
I
G
----------------------
D
S
L
S
L
A
Y
A
A
S
V
E
-
A
----------------
L
------------------
S
S
H
P
I
A
K
A
I
V
K
Y
------
A
K
E
Q
-----------
G
V
K
I
L
E
----
V
K
D
F
--------
K
E
I
S
G
-------------------------
I
G
V
--
R
G
K
I
------
S
D
--
K
I
I
E
V
--
K
K
---------------------------------------------
A
E
N
-----
D
I
A
V
---
Y
I
--------------------------
N
G
E
P
---------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
48.26
33%
-72
- C2 -
2YJ6
2
?
B:
[13-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
---
T
P
I
V
-------------------
T
Q
F
---
I
G
----------------------
D
S
L
S
L
A
Y
A
A
S
V
E
-
A
----------------
L
------------------
S
S
H
P
I
A
K
A
I
V
K
Y
------
A
K
E
Q
-----------
G
VKIL
E
----
V
K
D
F
--------
K
E
I
S
G
-------------------------
I
G
V
--
R
G
K
I
------
S
D
--
K
I
I
E
V
--
K
K
---------------------------------------------
A
E
N
N
---
N
D
I
A
V
---
Y
I
--------------------------
N
G
E
P
---------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
47.99
33%
-73
- C2 -
2YJ6
1
?
A:
[13-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
---
T
P
I
V
-------------------
T
Q
F
---
I
G
----------------------
D
S
L
S
L
A
Y
A
A
S
V
E
-
A
----------------
L
------------------
S
S
H
P
I
A
K
A
I
V
K
Y
------
A
K
E
Q
-----------
G
V
K
I
L
E
----
V
K
D
F
--------
K
E
I
S
G
-------------------------
I
G
V
--
R
G
K
I
------
S
D
--
K
I
I
E
V
--
K
K
---------------------------------------------
A
E
N
N
---
N
D
I
A
V
---
Y
I
--------------------------
N
G
E
P
---------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
---
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
47.61
33%
-67
- C2 -
2YJ5
1
?
A:
[13-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
---
T
P
I
V
-------------------
T
Q
F
---
I
G
----------------------
D
S
L
S
L
A
Y
A
A
S
V
E
-
A
----------------
L
------------------
S
S
H
P
I
A
K
A
I
V
K
Y
------
A
K
E
Q
-----------
G
V
K
I
L
E
----
V
K
D
F
--------
K
E
I
S
G
-------------------------
I
G
V
--
R
G
K
I
------
S
D
--
K
I
I
E
V
--
K
K
---------------------------------------------
A
E
N
N
---
N
D
I
A
V
---
Y
I
--------------------------
N
G
E
P
---------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
-----
K
N
V
A
D
I
I
L
V
S
N
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
46.99
33%
-69
- C2 -
2YJ3
4
?
A:
[13-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
E
K
T
G
T
L
T
Y
G
---
T
P
I
V
-------------------
T
Q
F
---
I
G
----------------------
D
S
L
S
L
A
Y
A
A
S
V
E
-
A
----------------
L
------------------
S
S
H
P
I
A
K
A
I
V
K
Y
------
A
K
E
Q
-----------
G
V
K
I
L
E
----
V
K
D
F
--------
K
E
I
S
G
-------------------------
I
G
V
--
R
G
K
I
------
S
D
--
K
I
I
E
V
--
K
K
----------------------------------------------------
N
D
I
A
V
---
Y
I
--------------------------
N
G
E
P
---------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
--
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
-------
V
A
D
I
I
L
V
S
N
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
46.71
33%
-64
- C2 -
2YJ4
1
?
B:
[13-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
---
T
P
I
V
-------------------
T
Q
F
---
I
G
----------------------
D
S
L
S
L
A
Y
A
A
S
V
E
-
A
----------------
L
------------------
S
S
H
P
I
A
K
A
I
V
K
Y
------
A
K
E
Q
-----------
G
V
K
I
L
E
----
V
K
D
F
--------
K
E
I
S
G
-------------------------
I
G
V
--
R
G
K
I
------
S
D
--
K
I
I
E
V
--
K
K
---------------------------------------------
A
E
N
N
---
N
D
I
A
V
---
Y
I
--------------------------
N
G
E
P
---------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
45.83
33%
-68
- C2 -
2YJ5
1
?
B:
[13-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
---
T
P
I
V
-------------------
T
Q
F
---
I
G
----------------------
D
S
L
S
L
A
Y
A
A
S
V
E
-
A
----------------
L
------------------
S
S
H
P
I
A
K
A
I
V
K
Y
------
A
K
E
Q
-----------
G
V
K
I
L
E
----
V
K
D
F
--------
K
E
I
S
G
-------------------------
I
G
V
--
R
G
K
I
------
S
D
--
K
I
I
E
V
--
K
K
---------------------------------------------
A
E
N
N
---
N
D
I
A
V
---
Y
I
--------------------------
N
G
E
P
---------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------