@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0099: (2016-04-19 )
MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATADKARVVVRG
Atome Classification :
(20 SA)
---------------------------------------------------------.......----..10........20-.........30.......---.-40---........50........--60........70........80........90........100.......110.......120-..------...-..-130.---.----....-.140.-....--..150-------------.---.......---.---160---.----.--..-------.....170.......180.......190.......200.....-------.-------.210--.---.....--...220.......230-.--.......240.---..---.---...250.......260....-------------...270.......280.........290...----....300-.--.--...-.--.310.......320.......330.......340......-.350.......360.......---370.......380---.-----........390...-....400------..--------.......410.......420.......430.......440.......450.......460..--.....470--.......480.......490....-...500.......510.......520.......530.......540--------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------MGGKKFQ----AMPQL
P
S
T
V
L
D
R
V
--
F
E
Q
A
RQQ
P
E
A
I
A
L
RRCDG---T-
S
A
---
L
R
Y
R
E
L
V
A
E
V
G
G
L
A
A
D
L
R
--
A
Q
SVSRG
S
R
V
L
V
I
SDNG
P
E
T
Y
L
S
V
L
A
C
AKL
G
A
I
A
V
MADGNL
P
I
A
A
I
E
R
F
C
QITDP
A
A
A
LVAPG-
S
K
------
M
A
S
-
S
A
-
V
P
E
A
---
L
----
H
SI
P
-
V
I
A
V
D
-
I
A
A
V--TRE---------------S---EHSL
D
A
A
---S---L-----A----G--NA-------DQGSED
P
L
A
M
I
F
TSGTTGE
P
K
A
V
L
L
ANR
T
F
FAV
P
D
I
L
Q
KEGL
N
-------
W
-------
V
T
----
W
---
V
VGET--TYSPL
P
A
T
HI
G
G
L
W
W
--
I
--
L
T
C
L
MHG
G
L
C
V
---TG---G---E
N
T
T
S
L
L
E
I
L
TTNA
V
A
T
T
C
L
-------------
V
P
T
L
L
S
K
L
V
S
E
L
K
S--ANATV
P
S
L
R
L
V
GYGG----S
R
A
I
A
A
D
-
V
--
R
--
F
I
E
-A--TG
V
R
T
A
Q
V
Y
G
LSETG
C
T
A
L
C
L
PTDDG
S
I
V
K
I
EAGAVGRPY-PG
V
D
V
Y
L
A
ATDGIGPTAPGAG---PSA
S
F
G
T
L
W
IK-----S-----P
A
N
MLGYWN
N
P
E
R
T
-
A
E
V
L
I
--------DG--------WV
N
T
G
D
L
L
E
RRED
G
F
F
Y
I
KGRSS
E
M
I
I
CGGVNI
A
P
D
E
V
D
R
I
A
E
G
V
S
G
V
R
E
AACYEI
P
D
E
E
F
G
--
A
L
V
G
L
A
V
V
--ASAE
L
D
E
S
A
A
R
A
L
K
H
T
I
A
A
R
F
RRE-SEPMARP
S
T
I
V
I
V
TDIPRTQSGK
V
M
R
A
S
L
AAAATAD
K
A
R
V
V
VRG----------------------------------------------------------------------
1
PsiBlast_PDB
99.06
100%
-133
- C3 -
4IR7
2
?
A:
[12-532]
-----------------------------------------------------------------------
Q
L
P
S
T
V
L
D
R
V
--
F
E
Q
A
R
Q
Q
P
E
A
I
A
L
R
R
C
D
G
---
T
-
S
A
---
L
R
Y
R
E
L
V
A
E
V
G
G
L
A
A
D
L
R
--
A
Q
S
V
S
R
G
S
R
V
L
V
I
S
D
N
G
P
E
T
Y
L
S
V
L
A
C
A
K
L
G
A
I
A
V
M
A
D
G
N
L
P
I
A
A
I
E
R
F
C
Q
I
T
D
P
A
A
A
L
V
A
P
G
-------------
S
A
-
V
P
E
A
---
L
----
H
S
I
P
-
V
I
A
V
D
-
I
A
A
--------------------------
H
S
L
D
A
A
---
S
---
L
-----
A
----
G
--
N
A
-------
D
Q
G
S
E
D
P
L
A
M
I
F
T
S
--
T
G
E
P
K
A
V
L
L
A
N
R
T
F
F
A
V
P
D
I
L
Q
K
E
G
L
N
-------
W
-------
V
T
----
W
---
V
V
G
E
T
--
T
Y
S
P
L
P
A
T
H
I
G
G
L
W
W
--
I
--
L
T
C
L
M
H
G
G
L
C
V
---
T
G
---
G
---
E
N
T
T
S
L
L
E
I
L
T
T
N
A
V
A
T
T
C
L
-------------
V
P
T
L
L
S
K
L
V
S
E
L
K
S
--
A
N
A
T
V
P
S
L
R
L
V
G
Y
G
G
----
S
R
A
I
A
A
D
-
V
--
R
--
F
I
E
-
A
--
T
G
V
R
T
A
Q
V
Y
G
L
S
E
T
G
C
T
A
L
C
L
P
T
D
D
G
S
I
V
K
I
E
A
G
A
V
G
R
P
Y
-
P
G
V
D
V
Y
L
A
A
T
D
G
I
G
P
T
A
P
G
A
G
---
P
S
A
S
F
G
T
L
W
I
K
-----
S
-----
P
A
N
M
L
G
Y
W
N
N
P
E
R
T
-
A
E
V
L
I
--------
D
G
--------
W
V
N
T
G
D
L
L
E
R
R
E
D
G
F
F
Y
I
K
G
R
S
S
E
M
I
I
C
G
G
V
N
I
A
P
D
E
V
D
R
I
A
E
G
V
S
G
V
R
E
A
A
C
Y
E
I
P
D
E
E
F
G
--
A
L
V
G
L
A
V
V
--
A
S
A
E
L
D
E
S
A
A
R
A
L
K
H
T
I
A
A
R
F
R
R
E
-
S
E
P
M
A
R
P
S
T
I
V
I
V
T
D
I
P
R
T
Q
S
G
K
V
M
R
A
S
L
A
A
A
A
T
A
-------------------------------------------------------------------------------
23
HHSearch
97.51
100%
-129
- C3 -
4ISB
2
?
A:
[10-532]
---------------------------------------------------------------------
M
P
Q
L
P
S
T
V
L
D
R
V
--
F
E
Q
A
R
Q
Q
P
E
A
I
A
L
R
R
C
D
G
---
T
-
S
A
---
L
R
Y
R
E
L
V
A
E
V
G
G
L
A
A
D
L
R
--
A
Q
S
V
S
R
G
S
R
V
L
V
I
S
D
N
G
P
E
T
Y
L
S
V
L
A
C
A
K
L
G
A
I
A
V
M
A
D
G
N
L
P
I
A
A
I
E
R
F
C
Q
I
T
D
P
A
A
A
L
V
A
P
G
-
S
K
------
M
A
S
-
S
A
-
V
P
E
A
---
L
----
H
S
I
P
-
V
I
A
V
D
-
I
------------------------------
L
D
A
A
---
S
---
L
-----
A
----
G
--
N
A
-------
D
Q
G
S
E
D
P
L
A
M
I
F
T
S
G
T
T
G
E
P
K
A
V
L
L
A
N
R
T
F
F
A
V
P
D
I
L
Q
K
E
G
L
N
-------
W
-------
V
T
----
W
---
V
V
G
E
T
--
T
Y
S
P
L
P
A
T
H
I
G
G
L
W
W
--
I
--
L
T
C
L
M
H
G
G
L
C
V
---
T
G
---
G
---
E
N
T
T
S
L
L
E
I
L
T
T
N
A
V
A
T
T
C
L
-------------
V
P
T
L
L
S
K
L
V
S
E
L
K
S
--
A
N
A
T
V
P
S
L
R
L
V
G
Y
G
G
----
S
R
A
I
A
A
D
-
V
--
R
--
F
I
E
-
A
--
T
G
V
R
T
A
Q
V
Y
G
L
S
E
T
G
C
T
A
L
C
L
P
T
D
D
G
S
I
V
K
I
E
A
G
A
V
G
R
P
Y
-
P
G
V
D
V
Y
L
A
A
T
D
G
I
G
P
T
A
P
G
A
G
---
P
S
A
S
F
G
T
L
W
I
K
-----
S
-----
P
A
N
M
L
G
Y
W
N
N
P
E
R
T
-
A
E
V
L
I
--------
D
G
--------
W
V
N
T
G
D
L
L
E
R
R
E
D
G
F
F
Y
I
K
G
R
S
-
E
M
I
I
C
G
G
V
N
I
A
P
D
E
V
D
R
I
A
E
G
V
S
G
V
R
E
A
A
C
Y
E
I
P
D
E
E
F
G
--
A
L
V
G
L
A
V
V
--
A
S
A
E
----
A
A
R
A
L
K
H
T
I
A
A
R
F
R
R
E
-
S
E
P
M
A
R
P
S
T
I
V
I
V
T
D
I
P
R
T
Q
S
G
K
V
M
R
A
S
L
A
A
A
A
T
A
-------------------------------------------------------------------------------
2
PsiBlast_PDB
97.11
98%
-129
- C3 -
4ISB
2
?
A:
[10-532]
---------------------------------------------------------------------
M
P
Q
L
P
S
T
V
L
D
R
V
--
F
E
Q
A
R
Q
Q
P
E
A
I
A
L
R
R
C
D
G
---
T
-
S
A
---
L
R
Y
R
E
L
V
A
E
V
G
G
L
A
A
D
L
R
--
A
Q
S
V
S
R
G
S
R
V
L
V
I
S
D
N
G
P
E
T
Y
L
S
V
L
A
C
A
K
L
G
A
I
A
V
M
A
D
G
N
L
P
I
A
A
I
E
R
F
C
Q
I
T
D
P
A
A
A
L
V
A
P
G
-
S
K
------
M
A
S
-
S
A
-
V
P
E
A
---
L
----
H
S
I
P
-
V
I
A
V
D
-
I
------------------------------
L
D
A
A
---
S
---
L
-----
A
----
G
--
N
A
-------
D
Q
G
S
E
D
P
L
A
M
I
F
T
S
G
T
T
G
E
P
K
A
V
L
L
A
N
R
T
F
F
A
V
P
D
I
L
Q
K
E
G
L
N
-------
W
-------
V
T
----
W
---
V
V
G
E
T
--
T
Y
S
P
L
P
A
T
H
I
G
G
L
W
W
--
I
--
L
T
C
L
M
H
G
G
L
C
V
---
T
G
---
G
---
E
N
T
T
S
L
L
E
I
L
T
T
N
A
V
A
T
T
C
L
-------------
V
P
T
L
L
S
K
L
V
S
E
L
K
S
--
A
N
A
T
V
P
S
L
R
L
V
G
Y
G
G
----
S
R
A
I
A
A
D
-
V
--
R
--
F
I
E
-
A
--
T
G
V
R
T
A
Q
V
Y
G
L
S
E
T
G
C
T
A
L
C
L
P
T
D
D
G
S
I
V
K
I
E
A
G
A
V
G
R
P
Y
-
P
G
V
D
V
Y
L
A
A
T
D
G
I
G
P
T
A
P
G
A
G
---
P
S
A
S
F
G
T
L
W
I
K
-----
S
-----
P
A
N
M
L
G
Y
W
N
N
P
E
R
T
-
A
E
V
L
I
--------
D
G
--------
W
V
N
T
G
D
L
L
E
R
R
E
D
G
F
F
Y
I
K
G
R
S
-
E
M
I
I
C
G
G
V
N
I
A
P
D
E
V
D
R
I
A
E
G
V
S
G
V
R
E
A
A
C
Y
E
I
P
D
E
E
F
G
--
A
L
V
G
L
A
V
V
--
A
S
A
E
----
A
A
R
A
L
K
H
T
I
A
A
R
F
R
R
E
-
S
E
P
M
A
R
P
S
T
I
V
I
V
T
D
I
P
R
T
Q
S
G
K
V
M
R
A
S
L
A
A
A
A
T
A
-------------------------------------------------------------------------------
33
HHSearch
67.90
20%
-110
- C3 -
2VSQ
2
A:
[464-976]
--------------------------------------------------------------------------
K
P
L
T
Y
W
F
--
K
E
A
V
N
A
N
P
D
A
P
A
L
T
--
Y
S
---
G
-
Q
T
---
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
--
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
H
Q
E
-
M
--------
K
--
E
Q
-
A
A
E
L
---
P
----
Y
T
G
T
-
T
L
F
I
D
-
D
Q
---------------------------
T
R
F
E
E
Q
---
A
---
S
-----
D
----
P
--
A
T
-------
A
I
D
P
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
H
-----
V
D
-------
Y
-------
M
A
----
F
---
S
D
Q
D
T
--
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
--
F
--
Y
A
S
M
L
N
A
A
R
L
I
---
I
A
D
--
E
HTL
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
-------------
T
T
A
L
F
N
L
L
T
D
A
G
E
-----
D
W
M
K
G
L
R
C
I
L
F
G
G
----
E
R
A
S
V
P
H
V
R
--
K
--
A
L
R
I
M
--
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
V
V
H
D
L
P
-
D
S
I
S
S
L
P
I
G
K
P
I
-
S
N
A
S
V
Y
I
L
N
E
Q
S
-
Q
L
Q
--------
P
F
G
A
V
G
E
L
C
I
S
-----
G
-----
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
-
K
E
K
F
I
ENPFKPG-
E
T
--------
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
E
S
G
D
--
A
S
I
N
A
Y
L
V
--
N
R
T
-
Q
------
L
S
A
E
D
V
K
A
H
L
K
K
Q
-
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
--------------------------------------------------------------------------------
48
Fugue
67.31
20%
-90
- C3 -
4DG9
1
?
A:
[18-604]
-------------------------------------------------------------
N
S
L
----
L
D
L
Y
A
H
P
T
V
V
A
R
F
--
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
R
F
G
---
S
-
V
D
-----
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
--
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
T
-
T
P
------
T
P
A
-
N
G
-
L
P
---------------------------
C
V
P
---------------
V
---
R
H
L
P
A
A
P
---
A
---
S
-----
V
----
A
--
R
P
-------
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
L
C
-----
L
G
Q
S
-------
F
-------
L
A
----
F
---
A
P
Q
M
R
--
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
--
I
--
W
G
A
L
L
N
G
G
C
C
V
LND
L
G
---
P
---
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
-------------
T
A
S
L
F
N
T
L
V
D
L
-----
D
P
D
C
L
G
G
L
R
Q
L
L
T
G
G
----
D
I
L
S
V
P
H
-
V
--
R
--
R
A
L
-
L
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
T
D
D
D
L
E
E
D
D
I
-
P
I
G
K
A
I
-
A
G
T
A
V
L
L
L
D
E
H
G
Q
E
I
A
E
P
D
R
A
--------
G
E
I
V
A
F
-----
G
-----
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
-
R
A
S
F
V
--------
E
L
P
Y
RG
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
R
E
R
N
G
V
K
--
Q
L
L
C
A
W
T
G
--
K
A
D
A
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
-------------
P
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
R
R
L
E
L
D
P
D
Q
R
G
C
A
Q
L
W
S
E
L
L
G
C
E
V
G
ADFFLCGGN
S
L
L
A
L
Q
L
V
A
L
C
Q
S
A
GAGANLGLADLQANSR
L
D
Q
F
S
R
L
L
R
S
H
GLAPERLLE
11
PsiBlast_PDB
67.01
24%
-96
- C3 -
4RM3
1
?
A:
[13-514]
------------------------------------------------------------------------------
E
H
L
--
L
Q
T
N
R
V
R
P
D
K
T
A
F
--
V
D
D
---
I
-
S
S
---
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
--
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
------
V
L
K
-
A
A
-
L
T
K
S
---
D
----
H
E
V
Q
-
R
V
I
V
S
-
R
P
A
A
--
P
L
E
PGEVD
F
---------
A
---
E
F
V
G
A
H
A
---
P
---
L
-----
E
----
K
--
P
A
-------
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
E
L
Y
---
G
R
N
-------
T
-------
L
H
----
L
---
R
E
D
D
V
--
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
--
A
--
L
T
F
P
M
---------
T
V
---
G
---
A
T
T
L
L
M
G
E
R
P
T
P
D
A
V
F
K
R
W
L
GGVGGVKPT
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
P
N
L
--
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
----
E
-
A
L
P
A
E
-
I
G
Q
R
--
F
Q
R
-
H
--
F
G
L
D
I
V
D
G
I
G
S
T
E
M
L
H
I
F
L
S
N
L
P
D
-----
R
V
R
Y
G
T
T
G
W
P
V
-
P
G
Y
Q
I
E
L
R
G
-
D
G
G
G
P
V
A
D
G
E
P
--------
G
D
L
Y
I
H
-----
G
-----
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
-
R
D
T
F
Q
--------
G
G
--------
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
-
G
--
L
T
K
P
K
A
Y
V
--
V
P
R
P
G
Q
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
-----
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
-------------------------------------------------------------------------------------
40
HHSearch
66.78
20%
-104
- C3 -
4DG8
3
?
A:
[27-513]
--------------------------------------------------------------------------
P
T
V
V
A
R
F
--
S
E
M
A
A
L
H
P
H
R
E
A
I
R
--
D
R
---
F
-
G
S
---
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
--
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
T
-
T
--------
P
--
T
P
-
A
N
G
----
L
----
P
C
----
V
P
V
R
-------------------------------
H
L
P
A
A
---
P
---
A
S----
V
----
A
--
R
P
-------
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
L
C
L
G
-----
Q
S
-------
F
-------
L
A
----
F
---
A
P
Q
M
R
--
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
--
I
--
W
G
A
L
L
N
G
G
C
C
V
---
L
N
D--
L
GP-
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
-------------
T
A
S
L
F
N
T
L
V
D
L
D
P
-----
D
C
L
G
G
L
R
Q
L
L
T
G
G
----
D
I
L
S
V
P
H
V
R
--
R
--
A
L
L
R
H
--
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
T
D
D
D
-
L
E
E
D
D
I
P
I
G
K
A
I
-
A
G
T
A
V
L
L
L
D
E
H
G
Q
E
I
A
--------
E
P
D
R
A
G
E
I
V
A
F
-----
G
-----
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
-
R
A
S
F
V
E
L
P
Y
RG
R
L
L
R
--------
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
R
E
R
N
G
V
K
--
Q
L
L
C
A
W
T
G
---
K
-----------
A
D
A
S
P
Q
A
L
L
R
Q
-
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
L
R
R
L
E
E
-------------------------------------------------------------------------------
12
PsiBlast_PDB
66.75
24%
-98
- C3 -
4RLF
5
?
A:
[12-513]
------------------------------------------------------------------------------
E
H
L
--
L
Q
T
N
R
V
R
P
D
K
T
A
F
--
V
D
D
---
I
-
S
S
---
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
--
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
------
V
L
K
-
A
A
-
L
T
K
S
---
D
----
H
E
V
Q
-
R
V
I
V
S
-
R
P
A
A
--
P
L
E
PGEVD
F
---------
A
---
E
F
V
G
A
H
A
---
P
---
L
-----
E
----
K
--
P
A
-------
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
E
L
Y
---
G
R
N
-------
T
-------
L
H
----
L
---
R
E
D
D
V
--
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
--
A
--
L
T
F
P
M
---------
T
V
---
G
---
A
T
T
L
L
M
G
E
R
P
T
P
D
A
V
F
K
R
W
L
GGVGGVKPT
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
P
N
L
--
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
----
E
-
A
L
P
A
E
-
I
G
Q
R
--
F
Q
R
-
H
--
F
G
L
D
I
V
D
G
I
G
S
T
E
M
L
H
I
F
L
S
N
L
P
D
-----
R
V
R
Y
G
T
T
G
W
P
V
-
P
G
Y
Q
I
E
L
R
G
-
D
G
G
G
P
V
A
D
G
E
P
--------
G
D
L
Y
I
H
-----
G
-----
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
-
R
D
T
F
Q
--------
G
G
--------
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
-
G
--
L
T
K
P
K
A
Y
V
--
V
P
R
P
G
Q
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
-----
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
-------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.64
24%
-97
- C3 -
4ZJZ
6
?
A:
[17-518]
------------------------------------------------------------------------------
E
H
L
--
L
Q
T
N
R
V
R
P
D
K
T
A
F
--
V
D
D
---
I
-
S
S
---
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
--
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
------
V
L
K
-
A
A
-
L
T
K
S
---
D
----
H
E
V
Q
-
R
V
I
V
S
-
R
P
A
A
--
P
L
E
PGEVD
F
---------
A
---
E
F
V
G
A
H
A
---
P
---
L
-----
E
----
K
--
P
A
-------
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
E
L
Y
---
G
R
N
-------
T
-------
L
H
----
L
---
R
E
D
D
V
--
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
--
A
--
L
T
F
P
M
---------
T
V
---
G
---
A
T
T
L
L
M
G
E
R
P
T
P
D
A
V
F
K
R
W
L
GGVGGVKPT
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
P
N
L
--
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
----
E
-
A
L
P
A
E
-
I
G
Q
R
--
F
Q
R
-
H
--
F
G
L
D
I
V
D
G
I
G
S
T
E
M
L
H
I
F
L
S
N
L
P
D
-----
R
V
R
Y
G
T
T
G
W
P
V
-
P
G
Y
Q
I
E
L
R
G
-
D
G
G
G
P
V
A
D
G
E
P
--------
G
D
L
Y
I
H
-----
G
-----
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
-
R
D
T
F
Q
--------
G
G
--------
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
-
G
--
L
T
K
P
K
A
Y
V
--
V
P
R
P
G
Q
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
-----
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
-------------------------------------------------------------------------------------
32
HHSearch
66.44
22%
-103
- C3 -
3C5E
7
ACS2A_HUMAN
A:
[54-562]
---------------------------------------------------------------------------------------
G
K
R
P
P
S
P
A
L
W
W
V
N
G
KG-
K
E
L
M
---
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
-
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
-
V
--------
I
--
Q
E
-
V
D
T
V
---
A
SEC-
P
S
L
R
I
K
L
L
V
S
-
E
K
S
----
C
D
---------------
G
---
W
L
N
F
K
K
L
---
L
---
N
E
ASTT
H
----
H
--
C
V
-------
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
--
D
--
A
G
-------
W
-------
T
G
----
L
---
Q
A
S
D
I
--
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S-
L
--
M
E
P
W
A
L
G
A
C
T
F
---
V
H
LLP
K
---
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
-------------
A
P
I
V
Y
R
M
L
L
Q
Q
D
L
---
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
----
E
S
L
L
P
E
T
L
E
--
N
--
W
R
A
-
Q
--
T
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
K
-----
I
K
P
G
Y
M
G
T
A
A
-
S
C
Y
D
V
Q
I
I
D
D
K
G
-
N
V
L
--------
P
P
G
T
E
G
D
I
G
I
R
VKP
I
R
P
-----
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
A
N
I
R
--------
G
D
--------
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
--
E
V
V
K
A
F
V
V
--
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
-
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------------------------------------------------------------------------------
47
Fugue
66.26
24%
-87
- C3 -
1PG4
7
ACSA_SALTY
A:
[5-647]
HKHAIP
A
N
I
A
D
RCLIN
P
E
Q
Y
E
T
K
Y
K
Q
S
I
N
D
P
D
T
F
W
G
E
Q
G
KILDWITPYQK
V
K
N
T
S
FA
P
G
N
V
S
I
K
W
YED
G
T
L
N
L
A
A
N
C
L
D
R
H
--
L
Q
E
N
G
D
R
T
A
I
I
W
E
G
D
D
T
S
Q
--
S
-
K
H
---
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
--
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
D
E
-
G
V
R
AG
R
S
I
P
L
K
-
K
N
-
V
D
D
A
---
L
----
K
N
P
N
-
V
T
S
V
E
-
H
V
I
V
--
L
K
R
TG
S
D
I
D
W
Q
E
GRDLW
W
R
---
D
L
I
E
K
A
S
---
P
---
E
-----
H
----
Q
--
P
E
-------
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
F
D
YHPG
D
I
Y
W
-------
C
T
ADVG
W
---
V
T
G
H
S
YL
L
Y
G
P
L
A
C
G
------------
A
T
T
L
M
F
E
G
--
V
---
P
N
---
W
---
P
T
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
-------------
A
P
T
A
I
R
A
L
M
A
E
G
D
K
AI
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
-
W
--
K
--
K
I
G
-
K
--
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
---
G
A
I
E
L
K
A
G
S
A
T
R
P
F
-
F
G
V
Q
P
A
L
V
D
N
E
G
------
H
P
Q
---
E
G
A
T
E
G
N
L
V
I
T
-----
D
SW---
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
-
E
Q
T
Y
F
STF-----
K
N
--------
M
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
--
Q
A
I
Y
A
Y
V
T
--
L
N
H
G
E
E
P
S
--
P
E
L
Y
A
E
V
R
N
W
V
R
K
E
-
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
G
D
A
D
P
G
V
V
E
K
L
L
E
E
K
Q
A---------------------------------------------------------------
16
PsiBlast_PDB
66.26
24%
-97
- C3 -
4RMN
3
?
A:
[17-518]
------------------------------------------------------------------------------
E
H
L
--
L
Q
T
N
R
V
R
P
D
K
T
A
F
--
V
D
D
---
I
-
S
S
---
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
--
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
------
V
L
K
-
A
A
-
L
T
K
S
---
D
----
H
E
V
Q
-
R
V
I
V
S
-
R
P
A
A
--
P
L
E
PGEVD
F
---------
A
---
E
F
V
G
A
H
A
---
P
---
L
-----
E
----
K
--
P
A
-------
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
E
L
Y
---
G
R
N
-------
T
-------
L
H
----
L
---
R
E
D
D
V
--
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
--
A
--
L
T
F
P
M
---------
T
V
---
G
---
A
T
T
L
L
M
G
E
R
P
T
P
D
A
V
F
K
R
W
L
GGVGGVKPT
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
P
N
L
--
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
----
E
-
A
L
P
A
E
-
I
G
Q
R
--
F
Q
R
-
H
--
F
G
L
D
I
V
D
G
I
G
S
T
E
M
L
H
I
F
L
S
N
L
P
D
-----
R
V
R
Y
G
T
T
G
W
P
V
-
P
G
Y
Q
I
E
L
R
G
-
D
G
G
G
P
V
A
D
G
E
P
--------
G
D
L
Y
I
H
-----
G
-----
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
-
R
D
T
F
Q
--------
G
G
--------
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
-
G
--
L
T
K
P
K
A
Y
V
--
V
P
R
P
G
Q
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
-----
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
-------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.89
24%
-96
- C3 -
4RM2
2
?
A:
[12-513]
------------------------------------------------------------------------------
E
H
L
--
L
Q
T
N
R
V
R
P
D
K
T
A
F
--
V
D
D
---
I
-
S
S
---
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
--
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
------
V
L
K
-
A
A
-
L
T
K
S
---
D
----
H
E
V
Q
-
R
V
I
V
S
-
R
P
A
A
--
P
L
E
PGEVD
F
---------
A
---
E
F
V
G
A
H
A
---
P
---
L
-----
E
----
K
--
P
A
-------
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
E
L
Y
---
G
R
N
-------
T
-------
L
H
----
L
---
R
E
D
D
V
--
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
--
A
--
L
T
F
P
M
---------
T
V
---
G
---
A
T
T
L
L
M
G
E
R
P
T
P
D
A
V
F
K
R
W
L
GGVGGVKPT
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
P
N
L
--
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
----
E
-
A
L
P
A
E
-
I
G
Q
R
--
F
Q
R
-
H
--
F
G
L
D
I
V
D
G
I
G
S
T
E
M
L
H
I
F
L
S
N
L
P
D
-----
R
V
R
Y
G
T
T
G
W
P
V
-
P
G
Y
Q
I
E
L
R
G
-
D
G
G
G
P
V
A
D
G
E
P
--------
G
D
L
Y
I
H
-----
G
-----
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
-
R
D
T
F
Q
--------
G
G
--------
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
-
G
--
L
T
K
P
K
A
Y
V
--
V
P
R
P
G
Q
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
-----
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
-------------------------------------------------------------------------------------
44
HHSearch
65.81
24%
-98
- C3 -
4IZ6
2
ENTE_ECOLI
A:
[46-556]
---------------------------------------------------------------------------
P
L
T
D
I
L
--
T
R
H
A
A
--
S
D
S
I
A
V
I
--
D
G
---
E
-
R
Q
---
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
--
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
-
H
A
------
L
F
S
G
D
D
F
L
N
T
F
---
V
T
E
H
-
S
S
I
R
-
V
V
Q
L
L
-
N
D
S
---------------------
G
---
E
H
N
L
Q
D
A
---
I
---
N
H
P
A
--
E
DF--
T
--
A
T
-------
P
S
P
A
D
E
V
A
Y
F
Q
L
S
G
G
-
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
Y
S
V
R
R
--
S
--
V
E
-------
I
-------
C
Q
----
F
---
T
Q
Q
T
R
--
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
PG
S
--
L
G
V
F
L
A
G
G
T
V
V
---
L
A
A--
D
---
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
-------------
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
GE
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
----
A
R
L
S
A
T
L
A
A
--
R
--
I
P
A
-
E
--
I
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
S
A
E
----
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
-
N
P
L
--------
P
Q
G
E
V
G
R
L
M
T
R
-----
G
-----
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
-
A
S
A
F
D
A-------
N
G
--------
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
--
E
K
S
C
A
Y
L
V
--
V
K
E
-
P
------
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
-------------------------------------------------------------------------------
21
HHSearch
65.78
24%
-98
- C3 -
3ETC
11
?
A:
[57-559]
---------------------------------------------------------------------------
F
A
Y
D
V
V
--
D
V
Y
A
R
D
S
P
E
K
L
A
M
I
W
C
D
D
YG
N
E
-
K
I
---
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
--
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
A
E
-
D
D
------
V
P
--
E
Q
-
V
D
E
A
H
A
E
C
----
G
D
I
P
-
L
K
K
A
K
V
G
G
D
V
--
L
E
G
---------------
W
ID
F
R
K
E
L
E
E
S
---
S
PIF
E
-----
R
----
P
TG
E
V
-------
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
P
L
G
H
I
L
T
--
A
--
K
Y
-------
W
-------
Q
N
----
V
---
E
D
D
G
L
--
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K-
L
--
Y
G
Q
W
I
A
G
C
A
V
F
---
V
Y
D--
Y
DR-
F
E
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
-------------
P
P
T
I
Y
R
F
L
I
K
E
D
L
------
N
F
S
T
L
K
Y
A
V
V
A
G
----
E
P
L
N
P
E
V
F
N
--
R
--
F
L
E
-
F
--
T
G
I
K
L
M
E
G
F
G
Q
T
E
T
V
V
T
I
A
T
F
P
W
M
E
-----
P
K
P
G
S
I
G
K
P
T
-
P
G
Y
K
I
E
L
M
D
R
D
G
-
R
L
C
--------
E
V
G
E
E
G
E
I
V
I
N
-----
T
MEGKP
V
G
L
F
V
H
Y
G
K
D
P
E
R
T
-
E
E
T
W
H
--------
D
G
--------
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
--
Q
V
I
K
A
T
I
V
--
L
T
K
D
Y
-
T
-
P
S
D
S
L
K
N
E
L
Q
D
H
V
K
N
V
-
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
---------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.69
24%
-95
- C3 -
4RLQ
4
?
A:
[12-513]
------------------------------------------------------------------------------
E
H
L
--
L
Q
T
N
R
V
R
P
D
K
T
A
F
--
V
D
D
---
I
-
S
S
---
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
--
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
------
V
L
K
-
A
A
-
L
T
K
S
---
D
----
H
E
V
Q
-
R
V
I
V
S
-
R
P
A
A
--
P
L
E
PGEVD
F
---------
A
---
E
F
V
G
A
H
A
---
P
---
L
-----
E
----
K
--
P
A
-------
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
E
L
Y
---
G
R
N
-------
T
-------
L
H
----
L
---
R
E
D
D
V
--
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
--
A
--
L
T
F
P
M
---------
T
V
---
G
---
A
T
T
L
L
M
G
E
R
P
T
P
D
A
V
F
K
R
W
L
GGVGGVKPT
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
P
N
L
--
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
----
E
-
A
L
P
A
E
-
I
G
Q
R
--
F
Q
R
-
H
--
F
G
L
D
I
V
D
G
I
G
S
T
E
M
L
H
I
F
L
S
N
L
P
D
-----
R
V
R
Y
G
T
T
G
W
P
V
-
P
G
Y
Q
I
E
L
R
G
-
D
G
G
G
P
V
A
D
G
E
P
--------
G
D
L
Y
I
H
-----
G
-----
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
-
R
D
T
F
Q
--------
G
G
--------
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
-
G
--
L
T
K
P
K
A
Y
V
--
V
P
R
P
G
Q
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
-----
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
-------------------------------------------------------------------------------------
37
HHSearch
65.46
17%
-94
- C3 -
4OXI
1
?
A:
[52-570]
---------------------------------------------------------------------------
T
R
H
S
I
L
--
A
A
-
I
Q
A
N
R
H
A
P
A
L
W
--
V
K
---
Q
-
K
T
---
Y
T
Y
Q
E
M
T
D
M
A
L
S
L
S
D
Y
W
H
--
L
Q
G
V
---
Q
R
V
A
I
L
S
V
R
D
L
A
A
Y
S
A
I
W
A
S
Y
L
G
G
M
T
Y
I
P
L
N
A
R
A
T
T
E
Q
I
Q
E
T
L
I
A
T
Q
C
D
S
I
M
V
D
A
Q
-
Q
--------
L
--
S
R
-
L
S
S
L
---
L
E
T
CI
D
R
L
H
-
I
Y
A
L
P
-
D
V
D
V
E
P
L
R
Q
---------------
Q
Y
P-
Q
H
T
F
H
T
V
Q
I
T
E
---
Q
D
V---
E
LLVV
K
--
Y
--------
L
D
N
E
H
E
Y
A
Y
I
M
Q
T
S
G
S
T
G
K
P
K
R
I
A
V
S
Y
S
N
L
H
C
Y
I
S
Q
--
I
--
D
K
-------
L
-------
F
P
----
L
---
N
A
Q
D
R
--
V
G
Q
Y
S
D
L
T
F
D
L
S
V
H
D
--
I
--
F
Y
S
L
I
S
G
A
C
L
Y
---
V
V
P
--
E
---
L
A
K
L
S
P
A
E
F
I
H
H
H
Q
L
T
V
W
L
S
-------------
V
P
T
V
I
E
L
A
L
Q
R
Q
T
L
--
T
P
H
S
L
P
S
L
R
L
S
F
F
C
G
----
Q
A
L
L
H
D
L
A
E
--
Q
--
W
Q
Q
-
A
--
T
Q
Q
P
V
I
N
L
Y
G
P
T
E
C
T
I
A
V
T
Y
H
R
F
V
A
H
S
--
G
M
A
S
V
P
I
G
R
A
F
-
E
E
E
C
L
A
I
I
N
E
Q
G
-
E
L
M
R
F
E
S
A
---
P
E
G
Y
R
G
E
L
L
L
S
-----
G
-----
K
Q
L
V
K
G
Y
L
N
D
P
L
N
T
-
Q
S
A
F
F
QHEG----
R
L
--------
W
Y
R
S
G
D
I
V
T
K
-
S
N
G
V
L
I
H
L
G
R
R
D
H
Q
V
K
I
A
G
Q
R
V
E
L
E
E
I
E
T
V
V
R
R
V
T
Q
A
H
S
V
A
I
V
P
W
P
L
S
E
S
G
YA
S
G
T
V
A
F
V
D
--
T
H
T
-------
Q
W
Q
P
D
L
W
L
S
Q
C
K
Q
Q
-
L
N
P
T
F
V
P
K
R
W
Y
A
I
E
Q
L
P
R
----
K
T
D
I
K
A
L
Q
Q
Q
L
A
S
Q
------------------------------------------------------------------------------
15
PsiBlast_PDB
65.45
24%
-97
- C3 -
4EAT
4
?
A:
[17-518]
------------------------------------------------------------------------------
E
H
L
--
L
Q
T
N
R
V
R
P
D
K
T
A
F
--
V
D
D
---
I
-
S
S
---
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
--
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
------
V
L
K
-
A
A
-
L
T
K
S
---
D
----
H
E
V
Q
-
R
V
I
V
S
-
R
P
A
A
--
P
L
E
PGEVD
F
---------
A
---
E
F
V
G
A
H
A
---
P
---
L
-----
E
----
K
--
P
A
-------
A
T
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
E
L
Y
---
G
R
N
-------
T
-------
L
H
----
L
---
R
E
D
D
V
--
C
F
S
A
A
K
L
F
F
A
Y
G
L
G
N
--
A
--
L
T
F
P
M
---------
T
V
---
G
---
A
T
T
L
L
M
G
E
R
P
T
P
D
A
V
F
K
R
W
L
GGVGGVKPT
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
P
N
L
--
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
----
E
-
A
L
P
A
E
-
I
G
Q
R
--
F
Q
R
-
H
--
F
G
L
D
I
V
D
G
I
G
S
T
E
M
L
H
I
F
L
S
N
L
P
D
-----
R
V
R
Y
G
T
T
G
W
P
V
-
P
G
Y
Q
I
E
L
R
G
-
D
G
G
G
P
V
A
D
G
E
P
--------
G
D
L
Y
I
H
-----
G
-----
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
-
R
D
T
F
Q
--------
G
G
--------
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
P
G
V
L
E
A
A
V
V
G
V
A
D
E
H
-
G
--
L
T
K
P
K
A
Y
V
--
V
P
R
P
G
Q
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
-----
A
P
Y
K
Y
P
R
S
T
V
F
V
A
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
-------------------------------------------------------------------------------------
20
PsiBlast_PDB
64.86
23%
-78
- C3 -
3B7W
6
ACS2A_HUMAN
A:
[29-556]
----------------------------------------------------------
G
H
Q
E
V
P
----
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
R
P
P
S
P
A
L
W
W
V
N
G
---
K
-
G
K
E
L
M
W
N
F
R
E
L
-
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
--
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-
D
E
------
V
I
Q
-
E
--
V
D
T
V
---
A
----
S
E
C
P
-
S
L
R
I
K
-
L
L
V
S
--
E
K
S
---------------
C
---
D
G
W
L
N
F
K
---
K
---
L
-----
L
----
N
--
E
A
STTHHCV
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
---
M
A
E
H
S
Y
S
S
L
-
G
L
K
A
K
M
D
A
G
-------
W
TGLQAS
D
I
M
----
W
---
T
I
S
D
T
--
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
--
L
--
G
A
C
T
F
---
V
H
L
---
L
P
---
K
---
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
-------------
A
P
I
V
Y
R
M
L
L
Q
Q
D
L
S
--
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
----
S
L
L
P
E
T
L
-
E
--
N
--
W
R
A
-
Q
--
T
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
-----
M
K
I
K
P
G
Y
M
G
T
A
A
-
S
C
Y
D
V
Q
I
I
D
D
K
G
-
N
V
L
P
P
G
T
E
---
G
D
I
G
I
R
V
K
P
I
R
-----
P
-----
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
G
--------
D
F
--------
W
L
-
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
--
E
V
V
K
A
F
V
V
--
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
-
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
-------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.22
25%
-104
- C3 -
4FUQ
7
?
A:
[8-494]
-------------------------------------------------------------------------------
R
L
--
F
D
K
L
-
D
D
P
H
K
L
A
I
E
T
A
A
G
-----
D
K
---
I
S
Y
A
E
L
V
A
R
A
G
R
V
A
N
V
L
V
--
A
R
G
L
Q
V
G
D
R
V
A
A
Q
T
E
K
S
V
E
A
L
V
L
Y
L
A
T
V
R
A
G
G
V
Y
L
P
L
N
T
A
Y
T
L
H
E
L
D
Y
F
I
T
D
A
E
P
K
I
V
V
C
D
P
S
-
K
R
-------------------------
D
G
I
A
-
A
I
A
A
K
-
V
G
A
T
--
V
E
T
L
G
PDGRG
S
L
------
T
---
D
A
A
A
G
A
S
---
E
---
A
-----
F
----
A
--
T
I
-------
D
R
G
A
D
D
L
A
A
I
L
Y
T
S
--
T
G
R
S
K
G
A
M
L
S
H
-------
D
N
L
A
S
N
S
L
T
-------
L
-------
V
D
----
Y
W
RF
T
P
D
D
V
--
L
I
H
A
L
P
I
Y
H
T
H
G
L
F
V
--
A
S
N
V
T
L
F
A
R
G
S
M
I
F
---
L
P
---
K
---
F
D
P
D
K
I
L
D
L
---
M
A
R
A
T
V
L
M
G
------------
V
P
T
F
Y
T
R
L
L
Q
S
P
R
L
--
T
K
E
T
T
G
H
M
R
L
F
-
I
S
G
----
S
A
P
L
L
A
D
-
T
--
H
R
E
W
S
A
-
K
--
T
G
H
A
V
L
E
R
Y
G
M
T
E
T
N
M
N
T
-
S
N
P
Y
D
G
D
R
V
----
P
G
A
V
G
P
A
L
-
P
G
V
S
A
R
V
--------
T
D
P
E
T
G
KEL
P
R
G
D
I
G
M
I
E
V
K
-----
G
-----
P
N
V
F
K
G
Y
W
R
M
P
E
K
T
K
S
E
F
R
D
--------
D
G
--------
F
F
I
T
G
D
L
G
K
I
D
E
R
G
Y
V
H
I
L
G
R
G
K
D
L
V
I
T
G
G
F
N
V
Y
P
K
E
I
E
S
E
I
D
A
M
P
G
V
V
E
S
A
V
I
G
V
P
H
A
D
F
G
--
E
G
V
T
A
V
V
V
R
D
K
G
A
T
I
D
E
A
Q
V
L
H
G
L
D
G
Q
L
A
K
F
K
--------
M
P
K
K
V
I
F
V
D
D
L
P
R
N
T
M
G
K
V
Q
K
N
V
L
-------------------------------------------------------------------------------------