@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0107c: (2016-04-19 )
MKIPGVATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLELTGPVVQSVVQTTGRAIGVRGSHNESPDGMTPPVRWRSGRRVHFDLDPLLPFPRWHEHAAMVEEPVRRIPGVAEAHVEGSLGRLVVELEPDADSDIAVDEVRDVVSAVAADIFLAGSVSSPNSAPFADPGNPLAILVPLTAAAMDLVAMGATVTGWVARLPAAPQTTRALAALINHQPRMVSLMESRLGRVGTDIALAATTAAANGLTQSLGTPLLDLVQRSLQISEAAAHRRVWRDREPALASPRRPQAPVVPIISSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAAIDTAKGSRAGPVEQYVNQAANGSLIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQAFAAVLGRGLANTGQLVLDPGALRRLDRVRVVVIDGAALRGDNRAVLHAQGDEPGWDDDRVYEVADALLHGEQAPEPDPDELPATGARLRWAPAQGPSATPAQGLEHADLVVDGQCVGSVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTEDLSASVGSTHPPGTPLLKLVRELRADRGPVLLITAVHRDFASTDTLAALAIADVGVALDDPRGATPWTADLITGTDLAAAVRILSALPVARAASESAVHLAQGGTTLAGLLLVTGEQDKTTNPASFRRWLNPVNAAAATALVSGMWSAAKVLRMPDPTPQPLTAWHALDPEIVYSRLAGGSRPLAVEPGIPAWRRILDDLSYEPVMAPLRGPARTLAQLAVATRHELADPLTPILAVGAAASAIVGSNIDALLVAGVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVATTRRRLEAARHATRTATVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLEVDESFLTGESLPVDKQVDPVAVNDPDRASMLFEGSTIVAGHARAIVVATGVGTAAHRAISAVADVETAAGVQARLRELTSKVLPMTLAGGAAVTALALLRRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTARGALVRSPRTIEALGRVDTICFDKTGTLTENRLRVVCALPSSTAAERDPLPQTTDAPSAEVLRAAARASTQPHNGEGHAHATDEAILAAASALAGSLSSQGDSEWVVLAEVPFESSRGYAAAIGRVGTDGIPMLMLKGAPETILPRCRLADPGVDHEHAESVVRHLAEQGLRVLAVAQRTWDNGTTHDDETDADAVDAVAHDLELIGYVGLADTARSSSRPLIEALLDAERNVVLITGDHPITARAIARQLGLPADARVVTGAELAVLDEEAHAKLAADMQVFARVSPEQKVQIVAALQRCGRVTAMVGDGANDAAAIRMADVGIGVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTILVGGNVGEVLFTVIGTAFGAGRAPVGTRQLLLVNLLTDMFPALAVAVTSQFAEPDDAEYPTDDAAERAQREHRRAVLIGPTPSLDAPLLRQIVNRGVVTAAGATAAWAIGRWTPGTERRTATMGLTALVMTQLAQTLLTRRHSPLVIATALGSAGVLVGIIQTPVISHFSGVPRWDRSPGRASSAPRQEPPQSQRWHRSGWQAQSVSCNLMNALTTRKTLTRVDRTYRRPR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720----..-.-.....730.......740.......750.......760.......770.......780......------.-------------790-----------.........800.......810.......820.......830.......840.......850.......860.......870.......880...--....890.......900.......910...---....920.......930.......940.......950..-....-.-960........970.......980.......990--------.........1000......1010......1020......1030......1040......1050......1060......1070.------------------------.....-------1080----..-------..----.....1090---------....---------...1100----------.....---------.---1110-----------.........1120---------------......---1130......1140......1150--...--.--.--.1160---.......1170......------1180-------.--------..--....1190....--.---.1200.-----.....1210...-....-1220......1230......1240......1250......1260......1270......1280-------------------------...-------------------------..--.1290...-----...1300-----.......--.1310........1320......1330......1340......1350......1360......1370......1380......1390......1400......1410-.........1420......1430......1440......1450......1460.....--.1470......1480.......1490-..--------------.....1500...------------------------...1510-.------------------------------------.-----------------------------------....1520......1530......-----------1540---------.----------.......1550......1560......1570......1580......1590......1600......1610......1620......1630
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKIP
G
V
A
T
V
L
G
G
V
T
N
G
V
A
Q
T
V
R
AGARLPG
S
A
A
A
A
V
Q
T
L
A
S
P
V
L
E
L
T
G
P
V
V
Q
S
V
V
Q
TTG
R
A
I
GVRGSHNESPDGMTPPVRWRSG
R
R
V
H
FDLDPLLPFP
R
W
H
E
H
A
A
M
V
E
E
P
V
R
RIPG
V
A
E
A
H
VEGSL
G
R
L
V
V
E
LEPDADSD
I
A
V
D
E
V
R
D
V
V
S
A
V
A
A
D
I
F
L
AGSVSSPNSAPFADPGN
P
L
A
I
L
V
P
L
T
A
A
A
M
D
L
V
AMGA
T
V
T
G
W
V
A
RLPAAP
Q
T
T
R
A
L
A
A
L
INHQ
P
R
M
V
S
L
M
E
S
R
L
GRVGT
D
I
A
L
A
A
T
T
A
AAN
G
L
T
Q
S
LG
T
P
L
L
D
L
V
Q
R
S
L
Q
I
S
E
A
A
A
H
R
R
V
WRDREPALASPRRPQA
P
V
V
P
I
ISSAGAKSQEP
R
H
S
W
AAAAAGEA
S
H
V
V
VGGSI
D
A
A
I
DTAKGSRAG
P
V
E
Q
Y
V
N
QAANG
S
L
I
A
A
A
S
A
L
VAGGGTE
D
A
A
G
A
I
L
AGV
P
R
A
A
H
M
G
R
Q
A
F
A
A
V
L
G
RGLANTG
Q
L
V
L
D
P
G
A
L
RRL
D
R
V
R
V
V
V
I
DGAALRGD
N
R
A
V
L
H
AQGDEPGWD
D
D
R
V
Y
E
V
A
D
A
L
LHGEQAPEPDPDELPATGA
R
L
R
WAPAQGPSATPAQGLEH
A
D
L
V
VDG
Q
C
VGSVDVGWEVD
P
Y
A
I
P
L
L
Q
T
A
HR
T
G
A
R
V
V
L
R
HVAGT
E
D
L
S
ASVGSTHPPG
T
P
L
L
K
L
V
R
E
L
RADRG
P
V
L
L
I
T
AVHRDFAST
D
T
L
A
A
L
A
I
A
D
V
G
V
ALDDPRGATPW
T
A
DLITG
T
D
L
A
A
A
V
R
I
L
S
ALPVARAASES
A
V
H
LAQGG
T
T
L
A
G
L
L
L
V
TGEQDKTT
N
P
A
S
F
R
R
W
L
N
P
V
N
A
A
A
A
T
A
L
V
S
G
M
W
S
A
A
K
V
LRMPDPTPQP
L
T
A
WHAL
D
P
E
I
V
Y
S
R
L-----AG-G-SR
P
L
AVEPG
I
P
A
W
R
R
I
L
D
DLSYEPVMAPLR
G
P
A
R
T
L
A
Q
L
A
V
A
T
R
H
E
LADP
L
T
P
I
L
A
V
G
A
A
A
S
A
I
------V-------------G-------------SN
I
D
A
L
L
V
A
G
V
M
T
V
N
A
I
T
G
G
V
Q
R
L
R
A
E
A
A
A
A
E
L
F
A
E
Q
D
Q
L
V
R
R
V
VV
P
A
V
A
T
T
R
R
R
L
E
A
A
RHAT
R
T
A
T
V
S
AKSLRVG
D
V
I
DLAAPEVVPAD
A
R
L
L
V
--
A
EDLEVDESFLTGESLPVDKQVD
P
V
AVNDP---D
R
A
S
M
L
FEG
S
T
I
V
AGH
A
R
A
I
V
V
A
TGV
G
T
A
A
H
R
A
I
S
A
V
AD-
V
E
T
A
-
A
-
G
-
V
Q
A
R
L
R
E
L
T
S
KVL
P
M
TLAG
G
A
A
V
T
A
L
A
L
L
R
----------
R
A
S
L
R
Q
A
V
ADG
V
A
I
A
V
AAVPEG
L
P
L
V
A
T
L
S
Q
L
A
A
A
Q
R
L
TARGALVRSP
R
T
I
E
A
LGRV
D
T
I
C
FDKTGTLTEN
R
L
R
V
V
C
ALPSSTA------------------------AERDP-------L-------PQ-------TT----DA
P
S
A
E
V
L
----------
R
A
A
A
---------RASTQPH----------NGEGH---------A---H--------------A
T
D
E
A
I
L
A
A
A
S
A
L
---------------
A
G
SLSS---QGDS
E
W
V
V
L
A
EVPFESSR
G
Y
A
A
A
I--GRV--G--T--DGI
P
----
M
L
M
LKGA
P
E
T
ILPRCRL------ADP--------G--------V
D
--
H
E
H
A
E
S
V
V
R
H
L
A
--E---Q
G
L
R
V
L
-----
A
V
A
Q
RTW-DNGT-THDD-ETD
A
D
A
V
D
A
V
A
H
D
L
E
L
I
G
YVGLADTARSSS
R
P
L
I
E
A
L
LDAER
N
V
V
L
I
TGDHP
I
T
A
R
A
I
A
R
Q
LGL-------------------------PAD-------------------------
A
R
--
V
VTG
A
E
L
A
-----
V
LD
E
E
-------
A
H
A
K
L
A
A
--
D
M
Q
--
V
F
ARV
S
P
E
Q
K
V
Q
I
V
A
A
L
Q
RCG
R
V
T
A
M
VGDGAND
A
A
A
I
R
M
A
D
V
GIGVSGRGSSAARG
A
A
D
I
V
L
TDD
D
L
G
V
L
L
D
A
L
VEG
R
S
M
W
AGVR
D
A
V
T
I
L
VGG
N
V
G
E
V
----
L
F
T
V
I
G
T
AFGAGRAPVG
T
R
Q
L
L
L
V
N
L
L
T
D
M
F
P
A
L
A
V
A
V
T
S
QFAEPDDAEYPT
D
D
A
A
E
R
--
A
Q
R
E
HR
R
A
V
L
IGP-TPSL
D
A
P
L
L
R
-
Q
-
I
V
--------------NRG
V
V
TAAGAT
A
------------------------
A
W
A
IGRW-T------------------------------------P-----------------------------------GTE
R
R
T
A
T
M
G
L
T
A
L
V
M
T
Q
L
A
Q
T
L
L
-----------TR-----------R----------HS
P
L
V
I
A
TALGSA
G
V
L
V
G
IIQ
T
P
V
I
S
HFSGVPRWDRSPGRASSAPRQEPPQSQ
R
W
HRSGWQAQSVS
C
N
L
M
N
A
L
T
T
R
K
T
L
T
R
V
D
R
T
YRRPR
102
HHSearch
87.80
24%
-60
- C2 -
2ZXE
6
?
A:
[44-994]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
-----
G
T
D
L
-
T
R
G
L
T
N
A
--
R
A
K
E
I
L
A
R
D
G
------
P
N
S
--
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
------
A
-------------
Y
G
I
Q
A
A
TEDEPAN
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
----------------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
-
T
-
P
-
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
TENQSGA
A
-------
F
D
-------
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
---------
L
C
N
R
A
V
F
Q
A
GQDNVPIL
K
R
S
V
A
---------
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
-------------------
E
L
C
C
G
S
V
Q
G
M
R
D
R
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
--
H
E
N
--
E
--
K
SS
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
------
I
L
L
NG
A
E
E
P
LK
E
--------
D
M
--
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
-----
G
F
C
H
F
A
L
-
P
E
D
K
-
Y
N
E
G
Y
P
F
D
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
-------------------------
I
S
E
GNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
--
V
V
H
G
S
D
L
K
-----
D
L
S
T
E
-------
V
L
D
D
I
L
H
Y
H
T
E
I
--
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
----
T
P
F
L
V
F
I
I
G
N
-
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
-------------------
R
N
P
K
T
D
K
L
V
N
E
R
L
I
S
-
M
A
Y
G
--------------
Q
I
G
M
I
Q
A
L
G
G
F
F
------------------------
S
Y
F
V
I
L
A
-
E
N
GFLPMDLIGK
R
V
R
W
D
DRWIS
D
V
E
D
SFG
Q
Q
W
T
Y
E
Q
R
K
-----------------------------------
I
V
E
F
T
C
H
T
S
F
F
I
S
I
V
V
V
Q
W
A
D
L
I
I
-----------
C
K
-----------
T
RRNSIFQQGM
K
N
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
C
P
G
T
D
V
A
L
R
M
Y
P
L
K
P
S
W
W
F
--------------------------------------------------
124
Fugue
85.22
25%
-66
- C4 -
1SU4
3
AT2A1_RABIT
A:
[1-994]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
-----
G
V
-
S
-
E
-----
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EEGEET
I
-------------
T
-------------
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
---------
P
E
M
G
K
V
Y
R
A
-----
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
IK
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
VNQ
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
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M
A
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-
T
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Q
D
-
K
T
P
-
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
FNDPVHGGSW
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
YAP
E
G
E
V
L
K
N
D
K
P
-------
I
-------
R
S
-------
G
Q
----
F
D
G
L
V
E
L
A
----------
T
I
C
A
L
CND
S
----
S
L
D
F
N
E
T
----------
K
G
V
Y
E
---------
K
V
G
-
E
--------------
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEVRNLSKVER
A
N
A
C
N
S
---
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
--
C
S
P
--
A
--
K
--
S
S
R
A
AVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
------
V
R
V
--------
G
T
T
R
V
P
MT
G
P
V
--
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
---
D
T
L
R
C
L
-----
A
L
A
T
R
D
T
-
P
P
K
R
-
E
E
M
V
-
L
D
D
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
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I
Q
L
C
R
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A
G
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R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
FGENE--------------------
E
V
A
-------------------------
D
R
--
A
Y
T
G
R
E
F
D
-----
D
L
P
L
A
-------
E
Q
R
E
A
C
R
--
R
A
C
--
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
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E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
----
V
C
I
F
L
T
A
A
L
G
L
P
E
-
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
--
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
LI
S
G
W
L
F
F
R
Y
M
A
I
G
G
-
Y
V
G
A
A
T
V
G
A
A
-
A
-
W
W
F
MYAEDGPGVTYHQ
L
T
H
F
M
Q
C
T
E
D
H
P
------------------------
H
F
E
G
L
D
C
-
E
------------------------------------
I
-----------------------------------
F
E
A
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
LSENQSLMRM
P
P
-----------
W
----------
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
------------------------
125
Fugue
84.71
22%
-46
- C4 -
3B8E
6
AT1A1_PIG
A:
[1-998]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
GTDLS
R
G
-
L
-
T
P
A
R
A
A
E
I
L
A
R
D
G
P
N
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
R
Q
L
F
G
G
F
S
M
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
T
E
E
E
P
Q
-------
N
-------------
D
-------------
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
--
Q
A
L
V
I
--------------
R
N
G
E
K
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
N
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
G
G
-
Q
T
P
-
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
E
Y
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
S
D
N
Q
I
------------------------
H
E
A
D
T
TENQSGV
S
-------
F
D
-------
K
T
----
S
A
T
W
L
A
L
S
----------
R
I
A
G
LCNR
A
V
F
Q
A
N
Q
E
N
L
P
I
----------
L
K
R
A
V
---------
A
---
G
--------------
D
A
S
E
S
A
L
L
K
C
I
E
L
---------------
C
C
G
S
V
K
---
E
M
R
E
R
Y
T
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
--
H
K
N
PN
T
--
A
--
E
P
R
H
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
------
I
L
I
--------
H
GKEQPLDE
E
L
--
K
D
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
-----
G
F
C
H
L
F
L
-
P
D
E
Q
F
P
E
G
F
-
Q
F
D
T
D
D
V
N
F
P
L
D
N
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
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T
A
K
A
I
A
K
G
V
G
I
ISEGN
E
T
V
E
D
IAARLNIPVSQVNPR
D
A
K
-------------------------
A
C
--
V
V
H
G
S
D
L
K
-----
D
M
T
S
E
-------
Q
L
D
D
I
L
K
--
Y
H
T
EI
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
----
T
P
F
L
I
F
I
I
A
N
I
P
L
-
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
--
E
S
D
I
M
K
R
Q
P
R
N
P
K
T
D
--
K
L
V
N
E
Q
L
I
S
M
A
Y
G
-
Q
I
G
M
I
Q
A
L
G
G
-
F
-
F
T
--------------
Y
F
V
I
L
A
E
N
G
F
L
P
IHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
E
Q
--
R
------------------------------------
K
-----------------------------------
I
V
E
F
T
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
-----------
C
K
-----------
T
----------
R
R
N
S
V
F
Q
Q
G
M
K
N
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
C
P
G
M
G
V
A
L
R
M
Y
P
L
K
P
T
W
W
F
C
A
F
P
Y
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
R
P
G
G
W
V
E
K
E
T
Y
Y
------
103
HHSearch
80.17
23%
-27
- C- -
3IXZ
-
ATP4A_PIG
A:
[48-999]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
N
D
H
Q
L
S
V
A
E
L
E
Q
K
Y
-----
Q
T
-
S
A
T
K
G
L
S
A
S
--
L
A
A
E
L
L
L
R
D
G
------
P
N
A
--
L
R
P
P
R
G
T
P
E
Y
V
K
F
A
R
Q
L
A
G
G
L
Q
C
L
M
W
V
A
A
A
I
C
L
I
------
A
F
A
IQASEGD
L
T
T
D
D
-------------
N
L
Y
L
A
L
A
L
I
A
V
V
V
V
T
G
C
F
G
Y
Y
Q
E
F
K
S
T
N
I
I
A
S
F
K
N
L
V
P
Q
Q
A
T
V
I
R
D
G
D
K
F
----------------
Q
I
N
A
D
Q
L
V
V
G
D
L
V
E
M
K
G
G
D
R
V
P
A
D
I
R
I
L
Q
--
A
Q
G
R
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
C
T
H
E
S
P
L
---
E
T
R
N
I
A
F
F
S
T
M
C
L
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G
T
A
Q
G
L
V
V
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T
G
D
R
T
I
I
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R
I
A
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L
A
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G
V
E
N
E
K
-
T
-
P
-
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A
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H
F
V
D
I
I
A
G
L
A
I
L
F
G
A
T
F
F
I
V
A
M
C
I
----------
G
Y
T
F
L
R
A
M
V
F
F
M
A
I
V
V
A
Y
V
P
E
G
L
L
A
T
V
T
V
C
L
S
L
T
A
K
R
L
A
S
K
N
C
V
V
K
N
L
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A
V
E
T
L
G
S
T
S
V
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
S
H
L
W
F
D
N
H
I
------------------------
H
S
A
D
T
-------
T
EDQSGQT
F
D
-------
Q
S
----
S
E
T
W
R
A
L
C
----------
R
V
L
T
---------
L
C
N
R
A
A
F
K
S
GQDAVPVP
K
R
I
V
I
---------
G
---
D
--------------
A
S
E
T
A
L
L
K
F
S
E
L
T
---------------
L
G
N
A
-
M
---
G
Y
R
E
R
F
P
K
V
C
E
I
P
F
N
S
T
N
K
F
Q
L
S
I
--
H
T
L
--
E
DP
R
--
D
P
R
H
----
V
L
V
M
K
G
A
P
E
R
V
L
E
R
C
S
S
------
I
L
I
--------
K
GQE
L
P
L
D
E
Q
W
--
R
E
A
F
Q
T
A
Y
L
S
L
G
--
G
---
L
G
E
R
V
L
-----
G
F
C
Q
L
Y
L
-
S
E
K
D
-
Y
P
P
G
Y
A
F
D
V
E
A
M
N
F
P
T
S
G
L
S
F
A
G
L
V
S
M
I
D
P
P
R
A
T
V
P
D
A
V
L
K
C
R
T
A
G
I
R
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
A
S
V
G
I
-------------------------
I
S
E
GS
E
T
V
E
D
I
A
ARLRVPVDQVNRKDAR
A
C
--
V
I
N
G
M
Q
L
K
-----
D
M
D
P
S
-------
E
L
V
E
A
L
R
TH
P
E
M
--
V
F
A
R
T
S
P
Q
Q
K
L
V
I
V
E
S
C
Q
R
L
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
A
A
K
N
A
A
D
M
I
L
L
D
D
N
F
A
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T
G
V
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Q
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
K
N
I
P
E
L
----
T
P
Y
L
I
Y
I
T
V
S
-
V
P
L
P
L
G
C
I
T
I
L
F
I
E
L
C
T
D
I
F
P
S
V
S
L
A
Y
E
K
A
E
S
D
I
M
H
L
R
P
-------------------
R
N
P
K
R
D
R
L
V
N
E
P
L
A
A
Y
S
-
Y
F
--------------
Q
I
G
A
I
Q
S
F
A
G
F
T
------------------------
D
Y
F
T
A
M
A
Q
E
------------------------------------
G
WFPLLCV
G
L
R
P
QWENHHLQDLQDSYG
Q
E
W
T
F
GQRL
Y
Q
Q
Y
T
C
Y
T
V
F
F
I
S
I
E
M
C
Q
I
A
D
V
L
I
-----------
R
K
TRRLSAFQQGF
F
----------
R
N
R
I
L
V
I
A
I
V
F
Q
V
C
I
G
C
F
L
C
Y
C
P
G
M
P
N
I
F
N
F
M
P
I
R
F
Q
W
W
L
--------------------------------------------------
1
PsiBlast_PDB
79.73
27%
-64
- C2 -
4XE5
4
?
A:
[110-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
E
------
E
-------------
E
-------------
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
-----
P
Q
Q
A
L
V
I
R
N
G
E
K
M
-------
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
N
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
G
G
-
Q
-
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
E
Y
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
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C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
-
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
-------
Q
S
G
V
S
F
D
K
T
S
A
T
W
L
-----------
A
L
S
---------
R
I
A
G
L
C
N
----------
R
A
V
F
Q
---------
A
---
N
QDNLPILKRAVAGD
A
S
E
S
A
L
L
K
C
I
E
V
C
---------------
C
G
S
V
K
E
---
M
R
E
-
R
Y
T
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
--
H
K
N
--
A
--
N
--
A
G
E
P
R
H
--
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
HG-
K
E
Q
--------
P
--------
L
D
--
E
E
L
K
D
A
F
Q
N
A
Y
L
--
E
L
G
G
L
G
E
R
V
L
-----
G
F
C
H
L
L
L
P
D
E
Q
F
-
P
E
G
F
-
Q
F
D
T
D
D
V
N
F
P
V
D
N
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
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A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
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A
K
G
V
G
I
ISEGNET
V
E
D
I
A
A
R
L
NIPVSQVN--
P
R
D
-------------------------
A
R
A
C
V
V
H
G
S
D
L
K
-----
D
M
T
P
E
Q
L
D
D
I
L
K
Y
H
T
E
I
---------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
TPFL
I
F
I
I
A
N
I
P
L
-----
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
--
A
E
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.08
28%
-64
- C2 -
5AW1
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
V
G
R
T
-
P
-
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
N
P
K
I
V
-
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
-
N
E
G
Y
-
P
F
D
-----
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.06
28%
-64
- C2 -
5AVY
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
V
G
R
T
-
P
-
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
N
P
K
I
V
-
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
-
N
E
G
Y
-
P
F
D
-----
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
78.01
28%
-64
- C2 -
5AVX
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
V
G
R
T
-
P
-
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
N
P
K
I
V
-
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
-
N
E
G
Y
-
P
F
D
-----
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.98
28%
-64
- C2 -
5AVW
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
V
G
R
T
-
P
-
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
N
P
K
I
V
-
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
-
N
E
G
Y
-
P
F
D
-----
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.95
28%
-64
- C2 -
5AW0
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
V
G
R
T
-
P
-
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
N
P
K
I
V
-
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
-
N
E
G
Y
-
P
F
D
-----
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.95
28%
-64
- C2 -
5AVR
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
V
G
R
T
-
P
-
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
N
P
K
I
V
-
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
-
N
E
G
Y
-
P
F
D
-----
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.93
28%
-65
- C2 -
5AVV
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
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F
V
V
A
G
D
L
V
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V
K
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--
A
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---
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F
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I
L
S
L
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L
----------
G
Y
S
W
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V
I
F
L
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G
I
I
V
A
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V
P
E
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L
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V
A
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M
W
F
D
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Q
I
------------------------
H
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A
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T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
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P
K
I
V
-
E
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P
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N
S
T
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K
Y
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S
I
H
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N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
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R
V
L
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L
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K
Y
-
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Y
-
P
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D
-----
A
D
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A
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ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
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I
-------
L
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H
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I
-------
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L
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-
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F
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----
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L
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T
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L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.93
28%
-64
- C2 -
5AVQ
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
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F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
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T
N
C
V
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G
T
A
R
G
V
V
V
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G
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G
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A
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G
-
L
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R
T
-
P
-
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A
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H
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H
I
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V
A
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L
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V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
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L
L
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L
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K
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C
L
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K
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L
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A
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K
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T
L
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Q
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R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
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S
A
L
L
K
C
I
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L
C
---------------
C
G
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V
Q
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---
M
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-
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--
S
--
S
--
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S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
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V
L
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A
L
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K
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-
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Y
-
P
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D
-----
A
D
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T
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D
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L
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A
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A
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ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
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I
-------
V
F
A
R
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K
L
I
I
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A
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----
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L
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D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.91
28%
-64
- C2 -
5AVT
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
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V
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G
G
D
R
I
P
A
D
L
R
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--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
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Q
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R
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P
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F
S
S
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N
P
L
---
E
T
R
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A
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C
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G
T
A
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-
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V
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F
F
I
L
S
L
I
L
----------
G
Y
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W
L
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A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
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L
L
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K
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K
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R
M
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V
A
H
M
W
F
D
N
Q
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------------------------
H
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A
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-------
T
-------
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QSGAAFD
K
T
----
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A
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A
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----------
R
I
A
A
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C
N------
R
A
V
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Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
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S
A
L
L
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C
---------------
C
G
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---
M
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--
S
--
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S
R
Y
----
L
L
V
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K
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A
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I
L
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R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
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M
K
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A
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Q
N
A
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L
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L
G
--
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---
L
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A
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K
Y
-
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Y
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D
-----
A
D
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T
T
D
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A
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A
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A
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G
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ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
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I
-------
V
F
A
R
T
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Q
K
L
I
I
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C
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A
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V
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A
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T
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T
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N
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P
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T
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F
-
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V
F
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----
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L
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L
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T
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L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.89
28%
-64
- C2 -
5AVU
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
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R
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---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
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R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
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G
G
D
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I
P
A
D
L
R
I
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S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
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P
Q
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P
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F
S
S
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N
P
L
---
E
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A
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V
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F
F
I
L
S
L
I
L
----------
G
Y
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L
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A
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F
L
I
G
I
I
V
A
N
V
P
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L
L
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K
T
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T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
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A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
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S
A
L
L
K
C
I
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L
C
---------------
C
G
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V
Q
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---
M
R
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Y
----
L
L
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A
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T
ILLNG
A
E
E
P
--------
L
--------
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A
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L
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--
G
---
L
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Y
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P
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-----
A
D
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N
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D
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C
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A
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A
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ISEGNET
I
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D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
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D
L
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D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
77.86
28%
-64
- C2 -
5AVS
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
V
G
R
T
-
P
-
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
N
P
K
I
V
-
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
-
N
E
G
Y
-
P
F
D
-----
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.86
28%
-64
- C2 -
2ZXE
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
V
G
R
T
-
P
-
I
A
I
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I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
N
P
K
I
V
-
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
-
N
E
G
Y
-
P
F
D
-----
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
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P
R
A
A
V
P
D
A
V
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K
C
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S
A
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I
K
V
I
M
V
T
G
D
H
P
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T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
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G
I
S
G
S
D
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K
Q
A
A
D
M
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L
L
D
D
N
F
A
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I
V
T
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V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.85
28%
-64
- C2 -
5AVZ
5
?
A:
[133-828]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
---
M
D
S
F
--
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
-------
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
S
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
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T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
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V
G
R
T
-
P
-
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A
I
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I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
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V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
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K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
QSGAAFD
K
T
----
S
A
T
W
S
A
L
S
----------
R
I
A
A
L
C
N------
R
A
V
F
Q
A
------------
G
Q
D
N
VPILKRSVA
G
---
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
Q
G
---
M
R
D
R
N
P
K
I
V
-
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
E
K
--
S
--
S
--
E
S
R
Y
----
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
ILLNG
A
E
E
P
--------
L
--------
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
---
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
-
N
E
G
Y
-
P
F
D
-----
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIGQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
-------
L
H
Y
H
T
E
I
-------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
-
L
V
F
I
I
G
N
V
----
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.74
27%
-65
- C3 -
3WGU
11
AT1A1_PIG
A:
[105-823]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
E
------
E
-------------
E
-------------
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
-----
P
Q
Q
A
L
V
I
R
N
G
E
K
M
-------
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
N
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
G
G
-
Q
-
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
E
Y
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
-------
Q
S
GVSF
D
K
T
S
A
T
W
L
A
L
S
R
I
A
G
L
C
N
R
A
V
F
---------
Q
A
N
Q
E
N
L
----------
P
I
L
K
R
---------
A
V
A
G
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
K
E
---
M
R
E
-
R
Y
T
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
--
H
K
N
--
P
--
N
--
T
A
E
P
R
H
--
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
HG-
K
E
Q
--------
P
--------
L
D
--
E
E
L
K
D
A
F
Q
N
A
Y
L
--
E
L
G
G
L
G
E
R
V
L
-----
G
F
C
H
L
F
L
P
D
E
Q
F
-
P
E
G
F
-
Q
F
D
T
D
D
V
N
F
P
L
D
N
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
V
E
D
I
A
A
R
L
NIPVSQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
-----
D
M
T
S
E
Q
L
D
D
I
L
K
Y
H
T
E
I
---------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
I
F
I
I
A
N
I
P
L
-----
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
--
A
E
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.22
27%
-64
- C3 -
3WGV
12
AT1A1_PIG
A:
[105-823]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
E
------
E
-------------
E
-------------
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
-----
P
Q
Q
A
L
V
I
R
N
G
E
K
M
-------
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
N
E
N
P
L
---
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
-
L
E
G
G
-
Q
-
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
E
Y
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
------------------------
H
E
A
D
T
-------
T
-------
E
N
-------
Q
S
GVSF
D
K
T
S
A
T
W
L
A
L
S
R
I
A
G
LCN
R
A
V
F
---------
Q
A
N
Q
E
N
L
----------
P
I
L
K
R
---------
A
V
A
G
D
--------------
A
S
E
S
A
L
L
K
C
I
E
L
C
---------------
C
G
S
V
K
E
---
M
R
E
-
R
Y
T
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
--
H
K
N
--
P
--
N
--
T
A
E
P
R
H
--
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
HG-
K
E
Q
--------
P
--------
L
D
--
E
E
L
K
D
A
F
Q
N
A
Y
L
--
E
L
G
G
L
G
E
R
V
L
-----
G
F
C
H
L
F
L
P
D
E
Q
F
-
P
E
G
F
-
Q
F
D
T
D
D
V
N
F
P
L
D
N
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
V
E
D
I
A
A
R
L
NIPVSQVN--
P
R
D
-------------------------
A
K
A
C
V
V
H
G
S
D
L
K
-----
D
M
T
S
E
Q
L
D
D
I
L
K
Y
H
T
E
I
---------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
I
F
I
I
A
N
I
P
L
-----
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
--
A
E
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------