@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0118c: (2016-04-19 )
MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARAAQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCFPMIQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTATSGRPGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLVLSKGAAYAQADNVIREFVEHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLLVGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSALLEAAADRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVNEGANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGFSGMEFETICRYRLPVTVVILNNGGVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELIAEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGVESGHLAKLNTTSAATPAISGDG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......-300........310.......320.......330.......340.......350.......360.....--..370...--....380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510--.........520.......530.......540.......550.......560.......570.......580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTTRSASP
C
T
V
LTD
G
C
H
L
V
V
D
A
L
KANDV
D
T
I
Y
G
VVGI
P
I
T
D
L
A
R
A
A
QASG
I
R
Y
I
G
F
R
HEASAGN
A
A
A
AA
G
F
LTARP
G
V
C
L
TTSGPGFLNG
L
P
A
L
ANATTN
C
F
P
M
I
Q
ISGSSSR
P
M
V
D
LQRG
D
Y
Q
D
L
D
Q
L
NAA
R
P
F
V
K
A
A
Y
RIG
Q
V
Q
D
I
G
R
G
V
A
R
A
I
R
T
ATSGRP
G
G
V
Y
L
DI
P
G
D
V
L
G
Q
A
V
E
ASAASG
A
I
WRPVDPAPRLLPA
P
E
A
I
D
R
A
L
D
V
L
A
QAQR
P
L
L
V
L
SKGAA
Y
A
Q
A
D
N
V
I
R
E
F
V
E
HTGIPFL
P
M
S
M
A
K
GLLPDSHP
Q
S
A
A
A
A
R
S
L
A
M
AR
A
D
V
V
L
L
V
G
A
R
L
N
W
L
LGNGESPQWS-AD-
A
K
F
I
Q
V
D
I
E
ASEFDSNR
P
I
V
A
PLTG
D
I
G
S
V
M
S
A
L
L
E
AAAD
R
S
S
VASAAWT
G
E
L
A
D
R
K
AR
N
S
A
K
M
R
R
--
R
LADDHH
P
--
M
R
F
Y
N
A
L
G
A
I
R
S
V
L
QRNP
D
V
Y
V
VNEGA
N
A
L
D
L
A
R
N
I
I
D
MHLPRHRLDSGTW
G
V
M
GIG
M
G
Y
A
I
A
A
A
VETG
R
P
V
V
A
IEGDSAFGFSGM
E
F
E
T
I
C
R
YRL
P
V
T
V
V
I
LNNGGVYRGDE
A
T
I
F
RSAAPVWRHDPAP
T
V
L
N
A
----
H
A
R
H
E
L
I
A
E
AFGGK
G
Y
HVS
T
P
T
E
L
E
S
A
L
T
D
A
L
ASNGP
S
L
I
D
CELDPADGVESG
H
L
A
K
LNTTSAATPAISGDG
21
PsiBlast_CBE
98.06
59%
-99
- C7 -
2Q29
4
OXC_ECOLI
B:
[7-550]
-----------
M
T
D
G
M
H
I
I
V
E
A
L
K
Q
N
N
I
D
T
I
Y
G
V
V
G
I
P
V
T
D
M
A
R
H
A
Q
A
E
G
I
R
Y
I
G
F
R
H
E
Q
S
A
G
Y
A
A
A
A
S
G
F
L
T
Q
K
P
G
I
C
L
T
V
S
A
P
G
F
L
N
G
L
T
A
L
A
N
A
T
V
N
G
F
P
M
I
M
I
S
G
S
S
D
R
A
I
V
D
L
Q
Q
G
D
Y
E
E
L
D
Q
M
N
A
A
K
P
Y
A
K
A
A
F
R
V
N
Q
P
Q
D
L
G
I
A
L
A
R
A
I
R
V
S
V
S
G
R
P
G
G
V
Y
L
D
L
P
A
N
V
L
A
A
T
M
E
K
D
E
A
L
T
T
I
V
K
V
E
N
P
S
P
A
L
L
P
C
P
K
S
V
T
S
A
I
S
L
L
A
K
A
E
R
P
L
I
I
L
G
K
G
A
A
Y
S
Q
A
D
E
Q
L
R
E
F
I
E
S
A
Q
I
P
F
L
P
M
S
M
A
K
G
I
L
E
D
T
H
P
L
S
A
A
A
A
R
S
F
A
L
A
N
A
D
V
V
M
L
V
G
A
R
L
N
W
L
L
A
H
G
K
K
-
G
W
A
-
A
D
-
T
Q
F
I
Q
L
D
I
E
P
Q
E
I
D
S
N
R
P
I
A
V
P
V
V
G
D
I
A
S
S
M
Q
G
M
L
A
E
L
K
Q
N
T
F
T
T
P
L
V
W
R
D
I
L
N
I
H
K
Q
Q
N
A
Q
K
M
H
E
--
K
L
S
T
D
T
Q
P
--
L
N
Y
F
N
A
L
S
A
V
R
D
V
L
R
E
N
Q
D
I
Y
L
V
N
E
G
A
N
T
L
D
N
A
R
N
I
I
D
M
Y
K
P
R
R
R
L
D
C
G
T
W
G
V
M
G
I
G
M
G
Y
A
I
G
A
S
V
T
S
G
S
P
V
V
A
I
E
G
D
S
A
F
G
F
S
G
M
E
I
E
T
I
C
R
Y
N
L
P
V
T
I
V
I
F
N
N
G
G
I
Y
R
G
D
G
V
D
L
S
G
A
G
A
------
P
S
P
T
D
L
L
H
----
H
A
R
Y
D
K
L
M
D
A
F
R
G
V
G
Y
N
V
T
T
T
D
E
L
R
H
A
L
T
T
G
I
Q
S
R
K
P
T
I
I
N
V
V
I
D
P
A
A
G
T
E
S
--------------------
1
PsiBlast_PDB
98.01
59%
-100
- C7 -
2Q27
9
OXC_ECOLI
A:
[7-551]
-----------
M
T
D
G
M
H
I
I
V
E
A
L
K
Q
N
N
I
D
T
I
Y
G
V
V
G
I
P
V
T
D
M
A
R
H
A
Q
A
E
G
I
R
Y
I
G
F
R
H
E
Q
S
A
G
Y
A
A
A
A
S
G
F
L
T
Q
K
P
G
I
C
L
T
V
S
A
P
G
F
L
N
G
L
T
A
L
A
N
A
T
V
N
G
F
P
M
I
M
I
S
G
S
S
D
R
A
I
V
D
L
Q
Q
G
D
Y
E
E
L
D
Q
M
N
A
A
K
P
Y
A
K
A
A
F
R
V
N
Q
P
Q
D
L
G
I
A
L
A
R
A
I
R
V
S
V
S
G
R
P
G
G
V
Y
L
D
L
P
A
N
V
L
A
A
T
M
E
K
D
E
A
L
T
T
I
V
K
V
E
N
P
S
P
A
L
L
P
C
P
K
S
V
T
S
A
I
S
L
L
A
K
A
E
R
P
L
I
I
L
G
K
G
A
A
Y
S
Q
A
D
E
Q
L
R
E
F
I
E
S
A
Q
I
P
F
L
P
M
S
M
A
K
G
I
L
E
D
T
H
P
L
S
A
A
A
A
R
S
F
A
L
A
N
A
D
V
V
M
L
V
G
A
R
L
N
W
L
L
A
H
G
K
K
-
G
W
A
-
A
D
-
T
Q
F
I
Q
L
D
I
E
P
Q
E
I
D
S
N
R
P
I
A
V
P
V
V
G
D
I
A
S
S
M
Q
G
M
L
A
E
L
K
Q
N
T
F
T
T
P
L
V
W
R
D
I
L
N
I
H
K
Q
Q
N
A
Q
K
M
H
E
--
K
L
S
T
D
T
Q
P
--
L
N
Y
F
N
A
L
S
A
V
R
D
V
L
R
E
N
Q
D
I
Y
L
V
N
E
G
A
N
T
L
D
N
A
R
N
I
I
D
M
Y
K
P
R
R
R
L
D
C
G
T
W
G
V
M
G
I
G
M
G
Y
A
I
G
A
S
V
T
S
G
S
P
V
V
A
I
E
G
D
S
A
F
G
F
S
G
M
E
I
E
T
I
C
R
Y
N
L
P
V
T
I
V
I
F
N
N
G
G
I
Y
R
G
D
G
V
D
L
S
G
A
G
A
------
P
S
P
T
D
L
L
H
----
H
A
R
Y
D
K
L
M
D
A
F
R
G
V
G
Y
N
V
T
T
T
D
E
L
R
H
A
L
T
T
G
I
Q
S
R
K
P
T
I
I
N
V
V
I
D
P
A
A
G
T
E
S
G
-------------------
22
PsiBlast_CBE
97.99
59%
-98
- C7 -
2Q28
7
OXC_ECOLI
B:
[7-554]
-----------
M
T
D
G
M
H
I
I
V
E
A
L
K
Q
N
N
I
D
T
I
Y
G
V
V
G
I
P
V
T
D
M
A
R
H
A
Q
A
E
G
I
R
Y
I
G
F
R
H
E
Q
S
A
G
Y
A
A
A
A
S
G
F
L
T
Q
K
P
G
I
C
L
T
V
S
A
P
G
F
L
N
G
L
T
A
L
A
N
A
T
V
N
G
F
P
M
I
M
I
S
G
S
S
D
R
A
I
V
D
L
Q
Q
G
D
Y
E
E
L
D
Q
M
N
A
A
K
P
Y
A
K
A
A
F
R
V
N
Q
P
Q
D
L
G
I
A
L
A
R
A
I
R
V
S
V
S
G
R
P
G
G
V
Y
L
D
L
P
A
N
V
L
A
A
T
M
E
K
D
E
A
L
T
T
I
V
K
V
E
N
P
S
P
A
L
L
P
C
P
K
S
V
T
S
A
I
S
L
L
A
K
A
E
R
P
L
I
I
L
G
K
G
A
A
Y
S
Q
A
D
E
Q
L
R
E
F
I
E
S
A
Q
I
P
F
L
P
M
S
M
A
K
G
I
L
E
D
T
H
P
L
S
A
A
A
A
R
S
F
A
L
A
N
A
D
V
V
M
L
V
G
A
R
L
N
W
L
L
A
H
G
K
K
-
G
W
A
-
A
D
-
T
Q
F
I
Q
L
D
I
E
P
Q
E
I
D
S
N
R
P
I
A
V
P
V
V
G
D
I
A
S
S
M
Q
G
M
L
A
E
L
K
Q
N
T
F
T
T
P
L
V
W
R
D
I
L
N
I
H
K
Q
Q
N
A
Q
K
M
H
E
--
K
L
S
T
D
T
Q
P
--
L
N
Y
F
N
A
L
S
A
V
R
D
V
L
R
E
N
Q
D
I
Y
L
V
N
E
G
A
N
T
L
D
N
A
R
N
I
I
D
M
Y
K
P
R
R
R
L
D
C
G
T
W
G
V
M
G
I
G
M
G
Y
A
I
G
A
S
V
T
S
G
S
P
V
V
A
I
E
G
D
S
A
F
G
F
S
G
M
E
I
E
T
I
C
R
Y
N
L
P
V
T
I
V
I
F
N
N
G
G
I
Y
R
G
D
G
V
D
L
S
G
A
G
A
------
P
S
P
T
D
L
L
H
----
H
A
R
Y
D
K
L
M
D
A
F
R
G
V
G
Y
N
V
T
T
T
D
E
L
R
H
A
L
T
T
G
I
Q
S
R
K
P
T
I
I
N
V
V
I
D
P
A
A
G
T
E
S
G
H
I
T
----------------
2
PsiBlast_PDB
97.86
59%
-98
- C7 -
2Q28
8
OXC_ECOLI
A:
[7-554]
-----------
M
T
D
G
M
H
I
I
V
E
A
L
K
Q
N
N
I
D
T
I
Y
G
V
V
G
I
P
V
T
D
M
A
R
H
A
Q
A
E
G
I
R
Y
I
G
F
R
H
E
Q
S
A
G
Y
A
A
A
A
S
G
F
L
T
Q
K
P
G
I
C
L
T
V
S
A
P
G
F
L
N
G
L
T
A
L
A
N
A
T
V
N
G
F
P
M
I
M
I
S
G
S
S
D
R
A
I
V
D
L
Q
Q
G
D
Y
E
E
L
D
Q
M
N
A
A
K
P
Y
A
K
A
A
F
R
V
N
Q
P
Q
D
L
G
I
A
L
A
R
A
I
R
V
S
V
S
G
R
P
G
G
V
Y
L
D
L
P
A
N
V
L
A
A
T
M
E
K
D
E
A
L
T
T
I
V
K
V
E
N
P
S
P
A
L
L
P
C
P
K
S
V
T
S
A
I
S
L
L
A
K
A
E
R
P
L
I
I
L
G
K
G
A
A
Y
S
Q
A
D
E
Q
L
R
E
F
I
E
S
A
Q
I
P
F
L
P
M
S
M
A
K
G
I
L
E
D
T
H
P
L
S
A
A
A
A
R
S
F
A
L
A
N
A
D
V
V
M
L
V
G
A
R
L
N
W
L
L
A
H
G
K
K
-
G
W
A
-
A
D
-
T
Q
F
I
Q
L
D
I
E
P
Q
E
I
D
S
N
R
P
I
A
V
P
V
V
G
D
I
A
S
S
M
Q
G
M
L
A
E
L
K
Q
N
T
F
T
T
P
L
V
W
R
D
I
L
N
I
H
K
Q
Q
N
A
Q
K
M
H
E
--
K
L
S
T
D
T
Q
P
--
L
N
Y
F
N
A
L
S
A
V
R
D
V
L
R
E
N
Q
D
I
Y
L
V
N
E
G
A
N
T
L
D
N
A
R
N
I
I
D
M
Y
K
P
R
R
R
L
D
C
G
T
W
G
V
M
G
I
G
M
G
Y
A
I
G
A
S
V
T
S
G
S
P
V
V
A
I
E
G
D
S
A
F
G
F
S
G
M
E
I
E
T
I
C
R
Y
N
L
P
V
T
I
V
I
F
N
N
G
G
I
Y
R
G
D
G
V
D
L
S
G
A
G
A
------
P
S
P
T
D
L
L
H
----
H
A
R
Y
D
K
L
M
D
A
F
R
G
V
G
Y
N
V
T
T
T
D
E
L
R
H
A
L
T
T
G
I
Q
S
R
K
P
T
I
I
N
V
V
I
D
P
A
A
G
T
E
S
G
H
I
T
----------------
23
PsiBlast_CBE
97.84
59%
-101
- C7 -
2Q27
8
OXC_ECOLI
B:
[7-549]
-----------
M
T
D
G
M
H
I
I
V
E
A
L
K
Q
N
N
I
D
T
I
Y
G
V
V
G
I
P
V
T
D
M
A
R
H
A
Q
A
E
G
I
R
Y
I
G
F
R
H
E
Q
S
A
G
Y
A
A
A
A
S
G
F
L
T
Q
K
P
G
I
C
L
T
V
S
A
P
G
F
L
N
G
L
T
A
L
A
N
A
T
V
N
G
F
P
M
I
M
I
S
G
S
S
D
R
A
I
V
D
L
Q
Q
G
D
Y
E
E
L
D
Q
M
N
A
A
K
P
Y
A
K
A
A
F
R
V
N
Q
P
Q
D
L
G
I
A
L
A
R
A
I
R
V
S
V
S
G
R
P
G
G
V
Y
L
D
L
P
A
N
V
L
A
A
T
M
E
K
D
E
A
L
T
T
I
V
K
V
E
N
P
S
P
A
L
L
P
C
P
K
S
V
T
S
A
I
S
L
L
A
K
A
E
R
P
L
I
I
L
G
K
G
A
A
Y
S
Q
A
D
E
Q
L
R
E
F
I
E
S
A
Q
I
P
F
L
P
M
S
M
A
K
G
I
L
E
D
T
H
P
L
S
A
A
A
A
R
S
F
A
L
A
N
A
D
V
V
M
L
V
G
A
R
L
N
W
L
L
A
H
G
K
K
-
G
W
A
-
A
D
-
T
Q
F
I
Q
L
D
I
E
P
Q
E
I
D
S
N
R
P
I
A
V
P
V
V
G
D
I
A
S
S
M
Q
G
M
L
A
E
L
K
Q
N
T
F
T
T
P
L
V
W
R
D
I
L
N
I
H
K
Q
Q
N
A
Q
K
M
H
E
--
K
L
S
T
D
T
Q
P
--
L
N
Y
F
N
A
L
S
A
V
R
D
V
L
R
E
N
Q
D
I
Y
L
V
N
E
G
A
N
T
L
D
N
A
R
N
I
I
D
M
Y
K
P
R
R
R
L
D
C
G
T
W
G
V
M
G
I
G
M
G
Y
A
I
G
A
S
V
T
S
G
S
P
V
V
A
I
E
G
D
S
A
F
G
F
S
G
M
E
I
E
T
I
C
R
Y
N
L
P
V
T
I
V
I
F
N
N
G
G
I
Y
R
G
D
G
V
D
L
S
G
A
G
A
------
P
S
P
T
D
L
L
H
----
H
A
R
Y
D
K
L
M
D
A
F
R
G
V
G
Y
N
V
T
T
T
D
E
L
R
H
A
L
T
T
G
I
Q
S
R
K
P
T
I
I
N
V
V
I
D
P
A
A
G
T
E
---------------------
41
HHSearch
97.56
59%
-98
- C7 -
2Q28
8
OXC_ECOLI
A:
[5-554]
---------
L
Q
M
T
D
G
M
H
I
I
V
E
A
L
K
Q
N
N
I
D
T
I
Y
G
V
V
G
I
P
V
T
D
M
A
R
H
A
Q
A
E
G
I
R
Y
I
G
F
R
H
E
Q
S
A
G
Y
A
A
A
A
S
G
F
L
T
Q
K
P
G
I
C
L
T
V
S
A
P
G
F
L
N
G
L
T
A
L
A
N
A
T
V
N
G
F
P
M
I
M
I
S
G
S
S
D
R
A
I
V
D
L
Q
Q
G
D
Y
E
E
L
D
Q
M
N
A
A
K
P
Y
A
K
A
A
F
R
V
N
Q
P
Q
D
L
G
I
A
L
A
R
A
I
R
V
S
V
S
G
R
P
G
G
V
Y
L
D
L
P
A
N
V
L
A
A
T
M
E
K
D
E
A
L
T
T
I
V
K
V
E
N
P
S
P
A
L
L
P
C
P
K
S
V
T
S
A
I
S
L
L
A
K
A
E
R
P
L
I
I
L
G
K
G
A
A
Y
S
Q
A
D
E
Q
L
R
E
F
I
E
S
A
Q
I
P
F
L
P
M
S
M
A
K
G
I
L
E
D
T
H
P
L
S
A
A
A
A
R
S
F
A
L
A
N
A
D
V
V
M
L
V
G
A
R
L
N
W
L
L
A
H
G
K
K
-
G
W
A
-
A
D
-
T
Q
F
I
Q
L
D
I
E
P
Q
E
I
D
S
N
R
P
I
A
V
P
V
V
G
D
I
A
S
S
M
Q
G
M
L
A
E
L
K
Q
N
T
F
T
T
P
L
V
W
R
D
I
L
N
I
H
K
Q
Q
N
A
Q
K
M
H
E
--
K
L
S
T
D
T
Q
P
--
L
N
Y
F
N
A
L
S
A
V
R
D
V
L
R
E
N
Q
D
I
Y
L
V
N
E
G
A
N
T
L
D
N
A
R
N
I
I
D
M
Y
K
P
R
R
R
L
D
C
G
T
W
G
V
M
G
I
G
M
G
Y
A
I
G
A
S
V
T
S
G
S
P
V
V
A
I
E
G
D
S
A
F
G
F
S
G
M
E
I
E
T
I
C
R
Y
N
L
P
V
T
I
V
I
F
N
N
G
G
I
-
Y
R
G
D
G
--
V
-
D
L
S
--
G
A
G
A
P
S
P
T
D
L
L
H
----
H
A
R
Y
D
K
L
M
D
A
F
R
G
V
G
Y
N
V
T
T
T
D
E
L
R
H
A
L
T
T
G
I
Q
S
R
K
P
T
I
I
N
V
V
I
D
P
A
A
G
T
E
S
G
H
I
T
----------------
3
PsiBlast_PDB
97.45
59%
-98
- C7 -
2Q29
4
OXC_ECOLI
A:
[7-550]
-----------
M
T
D
G
M
H
I
I
V
E
A
L
K
Q
N
N
I
D
T
I
Y
G
V
V
G
I
P
V
T
D
M
A
R
H
A
Q
A
E
G
I
R
Y
I
G
F
R
H
E
Q
S
A
G
Y
A
A
A
A
S
G
F
L
T
Q
K
P
G
I
C
L
T
V
S
A
P
G
F
L
N
G
L
T
A
L
A
N
A
T
V
N
G
F
P
M
I
M
I
S
G
S
S
D
R
A
I
V
D
L
Q
Q
G
D
Y
E
E
L
D
Q
M
N
A
A
K
P
Y
A
K
A
A
F
R
V
N
Q
P
Q
D
L
G
I
A
L
A
R
A
I
R
V
S
V
S
G
R
P
G
G
V
Y
L
D
L
P
A
N
V
L
A
A
T
M
E
K
D
E
A
L
T
T
I
V
K
V
E
N
P
S
P
A
L
L
P
C
P
K
S
V
T
S
A
I
S
L
L
A
K
A
E
R
P
L
I
I
L
G
K
G
A
A
Y
S
Q
A
D
E
Q
L
R
E
F
I
E
S
A
Q
I
P
F
L
P
M
S
M
A
K
G
I
L
E
D
T
H
P
L
S
A
A
A
A
R
S
F
A
L
A
N
A
D
V
V
M
L
V
G
A
R
L
N
W
L
L
A
H
G
K
K
-
G
W
A
-
A
D
-
T
Q
F
I
Q
L
D
I
E
P
Q
E
I
D
S
N
R
P
I
A
V
P
V
V
G
D
I
A
S
S
M
Q
G
M
L
A
E
L
K
Q
N
T
F
T
T
P
L
V
W
R
D
I
L
N
I
H
K
Q
Q
N
A
Q
K
M
H
E
--
K
L
S
T
D
T
Q
P
--
L
N
Y
F
N
A
L
S
A
V
R
D
V
L
R
E
N
Q
D
I
Y
L
V
N
E
G
A
N
T
L
D
N
A
R
N
I
I
D
M
Y
K
P
R
R
R
L
D
C
G
T
W
G
V
M
G
I
G
M
G
Y
A
I
G
A
S
V
T
S
G
S
P
V
V
A
I
E
G
D
S
A
F
G
F
S
G
M
E
I
E
T
I
C
R
Y
N
L
P
V
T
I
V
I
F
N
N
G
G
I
Y
R
G
D
G
V
D
L
S
G
A
G
A
------
P
S
P
T
D
L
L
H
----
H
A
R
Y
D
K
L
M
D
A
F
R
G
V
G
Y
N
V
T
T
T
D
E
L
R
H
A
L
T
T
G
I
Q
S
R
K
P
T
I
I
N
V
V
I
D
P
A
A
G
T
E
S
--------------------
24
PsiBlast_CBE
97.36
55%
-103
- C7 -
2JIB
7
OXC_OXAFO
B:
[9-563]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
G
R
I
K
S
L
N
V
V
S
----------
9
PsiBlast_PDB
97.26
55%
-102
- C7 -
2JIB
7
OXC_OXAFO
A:
[9-563]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
G
R
I
K
S
L
N
V
V
S
----------
27
PsiBlast_CBE
97.18
55%
-102
- C7 -
2JI7
10
OXC_OXAFO
B:
[9-563]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
G
R
I
K
S
L
N
V
V
S
----------
7
PsiBlast_PDB
96.97
55%
-103
- C7 -
2JI8
7
OXC_OXAFO
A:
[9-563]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
G
R
I
K
S
L
N
V
V
S
----------
5
PsiBlast_PDB
96.97
55%
-102
- C7 -
2JI6
9
OXC_OXAFO
A:
[9-563]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
G
R
I
K
S
L
N
V
V
S
----------
26
PsiBlast_CBE
96.90
55%
-102
- C7 -
2JI8
7
OXC_OXAFO
B:
[9-562]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
G
R
I
K
S
L
N
V
V
-----------
28
PsiBlast_CBE
96.87
55%
-100
- C7 -
2JI6
9
OXC_OXAFO
B:
[9-563]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
G
R
I
K
S
L
N
V
V
S
----------
25
PsiBlast_CBE
96.77
55%
-105
- C7 -
2JI9
6
OXC_OXAFO
B:
[9-553]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
--------------------
6
PsiBlast_PDB
96.56
55%
-101
- C7 -
2JI7
10
OXC_OXAFO
A:
[9-563]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
G
R
I
K
S
L
N
V
V
S
----------
8
PsiBlast_PDB
96.52
55%
-104
- C7 -
2JI9
6
OXC_OXAFO
A:
[9-553]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
--------------------
4
PsiBlast_PDB
96.07
55%
-103
- C7 -
2C31
4
OXC_OXAFO
A:
[9-552]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
---------------------
43
HHSearch
94.39
55%
-100
* C7 *
2C31
4
OXC_OXAFO
A:
[7-552]
---------
V
E
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
D
E
L
-
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
L
L
R
K
A
L
K
G
A
P
-
K
A
D
A
E
W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
K
M
T
A
E
T
P
S
G
M
--
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
-
I
Y
K
G
N
E
A
D
P
Q
P
--
G
----
V
I
S
C
-
T
R
L
T
----
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
---------------------
29
PsiBlast_CBE
93.23
55%
-84
- C- -
2C31
4
OXC_OXAFO
B:
[9-553]
-----------
L
T
D
G
F
H
V
L
I
D
A
L
K
M
N
D
I
D
T
M
Y
G
V
V
G
I
P
I
T
N
L
A
R
M
W
Q
D
D
G
Q
R
F
Y
S
F
R
H
E
Q
H
A
G
Y
A
A
S
I
A
G
Y
I
E
G
K
P
G
V
C
L
T
V
S
A
P
G
F
L
N
G
V
T
S
L
A
H
A
T
T
N
C
F
P
M
I
L
L
S
G
S
S
E
R
E
I
V
D
L
Q
Q
G
D
Y
E
E
M
D
Q
M
N
V
A
R
P
H
C
K
A
S
F
R
I
N
S
I
K
D
I
P
I
G
I
A
R
A
V
R
T
A
V
S
G
R
P
G
G
V
Y
V
D
L
P
A
K
L
F
G
Q
T
I
S
V
E
E
A
N
K
L
L
F
K
P
I
D
P
A
P
A
Q
I
P
A
E
D
A
I
A
R
A
A
D
L
I
K
N
A
K
R
P
V
I
M
L
G
K
G
A
A
Y
A
Q
C
D
D
E
I
R
A
L
V
E
E
T
G
I
P
F
L
P
M
G
M
A
K
G
L
L
P
D
N
H
P
Q
S
A
A
A
T
R
A
F
A
L
A
Q
C
D
V
C
V
L
I
G
A
R
L
N
W
L
M
Q
H
G
K
G
K
T
W
G
-
D
E
L
K
K
Y
V
Q
I
D
I
Q
A
N
E
M
D
S
N
Q
P
I
A
A
P
V
V
G
D
I
K
S
A
V
S
-
L
L
R
K
A
L
K
G
A
P
K
A
D
A
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W
T
G
A
L
K
A
K
V
D
G
N
K
A
K
L
A
G
--
K
M
T
A
E
T
P
S
GM
M
N
Y
S
N
S
L
G
V
V
R
D
F
M
L
A
N
P
D
I
S
L
V
N
E
G
A
N
A
L
D
N
T
R
M
I
V
D
M
L
K
P
R
K
R
L
D
S
G
T
W
G
V
M
G
I
G
M
G
Y
C
V
A
A
A
A
V
T
G
K
P
V
I
A
V
E
G
D
S
A
F
G
F
S
G
M
E
L
E
T
I
C
R
Y
N
L
P
V
T
V
I
I
M
N
N
G
G
I
Y
K
G
N
E
A
------------
D
P
Q
P
G
V
I
S
C
TRLT
R
G
R
Y
D
M
M
M
E
A
F
G
G
K
G
Y
V
A
N
T
P
A
E
L
K
A
A
L
E
E
A
V
A
S
G
K
P
C
L
I
N
A
M
I
D
P
D
A
G
V
E
S
--------------------