@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0127: (2016-04-19 )
MTRSDTLATKLPWSDWLSRQRWYAGRNRELATVKPGVVVALRHNLDLVLVDVTYTDGATERYQVLVGWDFEPASEYGTKAAIGVADDRTGFDALYDVAGPQFLLSLIVSSAVCGTSTGEVTFTREPDVELPFAAQPRVCDAEQSNTSVIFDRRAILKVFRRVSSGINPDIELNRVLTRAGNPHVARLLGAYQFGRPNRSPTDALAYALGMVTEYEANAAEGWAMATASVRDLFAEGDLYAHEVGGDFAGESYRLGEAVASVHATLADSLGTAQATFPVDRMLARLSSTVAVVPELREYAPTIEQQFQKLAAEAITVQRVHGDLHLGQVLRTPESWLLIDFEGEPGQPLDERRAPDSPLRDVAGVLRSFEYAAYGPLVDQATDKQLAARAREWVERNRAAFCDGYAVASGIDPRDSALLLGAYELDKAVYETGYETRHRPGWLPIPLRSIARLTAS
Atome Classification :
(20 SA)
------.........10........20........30..-......40.........50........60........70........80....----....90........100.......110........120.......130-........140.--......150-.------------........160---.---..----.---...170.......-180........190--.......200.......210......-.220.......230-------........240.......250.......260.....-.---.270--------.-----.------....---.280.---....---------..-290--..--.---.---.-.-.-..300.-------..-....310---.-.......320..-.....-330-------.-----.-....----.340.......350.......360...-----....370.....----..380--.........390......-.400.......410.......420.......430...-.-...440.......450...-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MTRSD
T
L
ATKL
P
W
S
D
W
L
S
R
Q
R
WYAGRNR
E
L
A
TV-KP
G
V
V
V
A
-
L
RHNL
D
L
V
L
V
D
V
T
YTDGAT
E
R
Y
Q
V
L
V
GWDFE
P
A
S
EYGT
K
A
A
IGVA----DDRT
G
F
D
A
L
Y
DVA
G
P
Q
F
L
L
S
L
I
V
S
SA-VCGTSTG
E
V
T
F
TREPDVELP--FAAQPRVCDAEQ--SN
T
S
V
I
F---D------------
R
R
A
I
L
K
V
F
R
R
V
---S---SG----I---NPD
I
E
L
N
R
V
L
TRA-G
N
-
P
H
V
A
R
L
L
G
A
Y
Q--FGRPNRS
P
T
D
A
L
A
Y
A
L
G
M
V
TEYEANA-AE
G
W
A
M
A
T
A
S
V
R
D
--------
L
F
AEGD
L
Y
A
HEVGGDFAGESY
R
L
G
E
A
V
A
S
V
H
A
T
L
A
D
-S---LGTA--------Q-----A------TF
P
V
---
D
R
M
L
A
---
R
L
S
S
---------
T
V
-
A
----
V
V
--
P
---
E
---
L
-
R
-
E
-
Y
A
P
T
I
E
-------
Q
Q
-
F
Q
K
L
A
A
----
E
-
A
I
T
V
Q
RVHGD
L
H
-
L
G
Q
V
L-RTP-------E-----
S
-
W
L
L
I
----DFEGEPGQPLDERRAPDS
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
YAAYGPLV----DQA----
T
D
K
Q
L
A
A
R
A
R
E
W
V
E
R
N
R
A
-
A
FCDG
Y
A
VASGIDPRD
S
A
L
L
L
G
A
Y
E
L
D
K
A
V
Y
ETGYET-R-HRPGWLPI
P
L
R
S
I
A
R
L
TAS-
12
PsiBlast_CBE
94.79
100%
-95
- C4 -
4O7P
1
MAK1_MYCTU
B:
[5-455]
----------
D
T
L
A
T
K
L
P
W
S
D
W
L
S
R
Q
R
W
Y
A
G
R
N
R
E
L
A
T
V
-
K
P
G
V
V
V
A
-
L
R
H
N
L
D
L
V
L
V
D
V
T
Y
T
D
G
A
T
E
R
Y
Q
V
L
V
G
W
D
F
E
P
A
S
E
Y
G
T
K
A
A
I
G
V
A
----
D
D
R
T
G
F
D
A
L
Y
D
V
A
G
P
Q
F
L
L
S
L
I
V
S
S
A
-
V
C
G
T
S
T
G
E
V
T
F
T
R
E
P
D
V
E
L
P
--
F
A
A
Q
P
R
V
C
D
A
E
Q
--
S
N
T
S
V
I
F
---
D
------------
R
R
A
I
L
K
V
F
R
R
V
---
S
---
S
G
----
I
---
N
P
D
I
E
L
N
R
V
L
T
R
A
-
G
N
-
P
H
V
A
R
L
L
G
A
Y
Q
--
F
G
R
P
N
R
S
P
T
D
A
L
A
Y
A
L
G
M
V
T
E
Y
E
A
N
A
-
A
E
G
W
A
M
A
T
A
S
V
R
D
--------
L
F
A
E
G
D
L
Y
A
H
E
V
G
G
D
F
A
G
E
S
Y
R
L
G
E
A
V
A
S
V
H
A
T
L
A
D
-
S
---
L
G
T
A
--------
Q
-----
A
------
T
F
P
V
---
D
R
M
L
A
---
R
L
S
S
---------
T
V
-
A
----
V
V
--
P
---
E
---
L
-
R
-
E
-
Y
A
P
T
I
E
-------
Q
Q
-
F
Q
K
L
A
A
----
E
-
A
I
T
V
Q
R
V
H
G
D
L
H
-
L
G
Q
V
L
-
R
T
P
-------
E
-----
S
-
W
L
L
I
----
D
F
E
G
E
P
G
Q
P
L
D
E
R
R
A
P
D
S
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
Y
A
A
Y
G
P
L
V
----
D
Q
A
----
T
D
K
Q
L
A
A
R
A
R
E
W
V
E
R
N
R
A
-
A
F
C
D
G
Y
A
V
A
S
G
I
D
P
R
D
S
A
L
L
L
G
A
Y
E
L
D
K
A
V
Y
E
T
G
Y
E
T
-
R
-
H
R
P
G
W
L
P
I
P
L
R
S
I
A
R
L
T
A
S
-
36
Fugue
92.20
100%
-93
- C4 -
4O7O
1
MAK1_MYCTU
A:
[6-454]
-----------
T
L
A
T
K
L
P
W
S
D
W
L
S
R
Q
R
W
Y
A
G
R
N
R
E
L
A
T
V
-
K
P
G
V
V
V
A
-
L
R
H
N
L
D
L
V
L
V
D
V
T
Y
T
D
G
A
T
E
R
Y
Q
V
L
V
G
W
D
---------
K
A
A
I
G
V
A
----
D
D
R
T
G
F
D
A
L
Y
D
V
A
G
P
Q
F
L
L
S
L
I
V
S
S
A
-
V
C
G
T
S
T
G
E
V
T
F
T
R
E
P
D
V
E
L
P
--
F
A
A
Q
P
R
V
C
D
A
E
Q
--
S
N
T
S
V
I
F
---
D
------------
R
R
A
I
L
K
V
F
R
R
V
---
S
---
S
G
----
I
---
N
P
D
I
E
L
N
R
V
L
T
R
A
-
G
N
-
P
H
V
A
R
L
L
G
A
Y
Q
--
F
G
-------
D
A
L
A
Y
A
L
G
M
V
T
E
Y
E
A
N
A
-
A
E
G
W
A
M
A
T
A
S
V
R
D
--------
L
F
A
E
G
D
L
Y
A
H
E
V
G
G
D
F
A
G
E
S
Y
R
L
G
E
A
V
A
S
V
H
A
T
L
A
D
-
S
---
L
G
T
A
--------
Q
-----
A
------
T
F
P
V
---
D
R
M
L
A
---
R
L
S
S
---------
T
V
-
A
----
V
V
--
P
---
E
---
L
-
R
-
E
-
Y
A
P
T
I
E
-------
Q
Q
-
F
Q
K
L
A
A
----
E
-
A
I
T
V
Q
R
V
H
G
D
L
H
-
L
G
Q
V
L
-
R
T
P
-------
E
-----
S
-
W
L
L
I
----
D
F
E
G
E
P
G
Q
P
L
D
E
R
R
A
P
D
S
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
Y
A
A
Y
G
P
L
V
----
D
Q
A
----
T
D
K
Q
L
A
A
R
A
R
E
W
V
E
R
N
R
A
-
A
F
C
D
G
Y
A
V
A
S
G
I
D
P
R
D
S
A
L
L
L
G
A
Y
E
L
D
K
A
V
Y
E
T
G
Y
E
T
-
R
-
H
R
P
G
W
L
P
I
P
L
R
S
I
A
R
L
T
A
--
1
PsiBlast_PDB
92.20
100%
-93
- C4 -
4O7O
1
MAK1_MYCTU
A:
[6-454]
-----------
T
L
A
T
K
L
P
W
S
D
W
L
S
R
Q
R
W
Y
A
G
R
N
R
E
L
A
T
V
-
K
P
G
V
V
V
A
-
L
R
H
N
L
D
L
V
L
V
D
V
T
Y
T
D
G
A
T
E
R
Y
Q
V
L
V
G
W
D
---------
K
A
A
I
G
V
A
----
D
D
R
T
G
F
D
A
L
Y
D
V
A
G
P
Q
F
L
L
S
L
I
V
S
S
A
-
V
C
G
T
S
T
G
E
V
T
F
T
R
E
P
D
V
E
L
P
--
F
A
A
Q
P
R
V
C
D
A
E
Q
--
S
N
T
S
V
I
F
---
D
------------
R
R
A
I
L
K
V
F
R
R
V
---
S
---
S
G
----
I
---
N
P
D
I
E
L
N
R
V
L
T
R
A
-
G
N
-
P
H
V
A
R
L
L
G
A
Y
Q
--
F
G
-------
D
A
L
A
Y
A
L
G
M
V
T
E
Y
E
A
N
A
-
A
E
G
W
A
M
A
T
A
S
V
R
D
--------
L
F
A
E
G
D
L
Y
A
H
E
V
G
G
D
F
A
G
E
S
Y
R
L
G
E
A
V
A
S
V
H
A
T
L
A
D
-
S
---
L
G
T
A
--------
Q
-----
A
------
T
F
P
V
---
D
R
M
L
A
---
R
L
S
S
---------
T
V
-
A
----
V
V
--
P
---
E
---
L
-
R
-
E
-
Y
A
P
T
I
E
-------
Q
Q
-
F
Q
K
L
A
A
----
E
-
A
I
T
V
Q
R
V
H
G
D
L
H
-
L
G
Q
V
L
-
R
T
P
-------
E
-----
S
-
W
L
L
I
----
D
F
E
G
E
P
G
Q
P
L
D
E
R
R
A
P
D
S
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
Y
A
A
Y
G
P
L
V
----
D
Q
A
----
T
D
K
Q
L
A
A
R
A
R
E
W
V
E
R
N
R
A
-
A
F
C
D
G
Y
A
V
A
S
G
I
D
P
R
D
S
A
L
L
L
G
A
Y
E
L
D
K
A
V
Y
E
T
G
Y
E
T
-
R
-
H
R
P
G
W
L
P
I
P
L
R
S
I
A
R
L
T
A
--
13
HHSearch
91.80
100%
-92
- C4 -
4O7O
1
MAK1_MYCTU
A:
[6-454]
-----------
T
L
A
T
K
L
P
W
S
D
W
L
S
R
Q
R
W
Y
A
G
R
N
R
E
L
A
T
V
-
K
P
G
V
V
V
A
L
R
-
H
N
L
D
L
V
L
V
D
V
T
Y
T
D
G
A
T
E
R
Y
Q
V
L
V
G
W
D
---------
K
A
A
I
G
V
A
----
D
D
R
T
G
F
D
A
L
Y
D
V
A
G
P
Q
F
L
L
S
L
I
V
S
S
A
-
V
C
G
T
S
T
G
E
V
T
F
T
R
E
P
D
V
E
L
P
--
F
A
A
Q
P
R
V
C
D
A
E
Q
--
S
N
T
S
V
I
F
---
D
------------
R
R
A
I
L
K
V
F
R
R
V
---
S
---
S
G
----
I
---
N
P
D
I
E
L
N
R
V
L
T
R
A
-
G
N
-
P
H
V
A
R
L
L
G
A
Y
Q
--
F
G
-------
D
A
L
A
Y
A
L
G
M
V
T
E
Y
E
A
N
A
-
A
E
G
W
A
M
A
T
A
S
V
R
D
--------
L
F
A
E
G
D
L
Y
A
H
E
V
G
G
D
F
A
G
E
S
Y
R
L
G
E
A
V
A
S
V
H
A
T
L
A
D
-
S
---
L
G
T
A
--------
Q
-----
A
------
T
F
P
V
---
D
R
M
L
A
---
R
L
S
S
---------
T
V
-
A
----
V
V
--
P
---
E
---
L
-
R
-
E
-
Y
A
P
T
I
E
-------
Q
Q
-
F
Q
K
L
A
A
----
E
-
A
I
T
V
Q
R
V
H
G
D
L
H
-
L
G
Q
V
L
-
R
T
P
-------
E
-----
S
-
W
L
L
I
----
D
F
E
G
E
P
G
Q
P
L
D
E
R
R
A
P
D
S
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
Y
A
A
Y
G
P
L
V
----
D
Q
A
----
T
D
K
Q
L
A
A
R
A
R
E
W
V
E
R
N
R
A
-
A
F
C
D
G
Y
A
V
A
S
G
I
D
P
R
D
S
A
L
L
L
G
A
Y
E
L
D
K
A
V
Y
E
T
G
Y
E
T
-
R
-
H
R
P
G
W
L
P
I
P
L
R
S
I
A
R
L
T
A
--
2
PsiBlast_PDB
91.43
100%
-91
- C4 -
4O7P
3
MAK1_MYCTU
A:
[6-454]
-----------
T
L
A
T
K
L
P
W
S
D
W
L
S
R
Q
R
W
Y
A
G
R
N
R
E
L
A
T
V
-
K
P
G
V
V
V
A
-
L
R
H
N
L
D
L
V
L
V
D
V
T
Y
T
D
G
A
T
E
R
Y
Q
V
L
V
G
W
D
---------
K
A
A
I
G
V
A
----
D
D
R
T
G
F
D
A
L
Y
D
V
A
G
P
Q
F
L
L
S
L
I
V
S
S
A
-
V
C
G
T
S
T
G
E
V
T
F
T
R
E
P
D
V
E
L
P
--
F
A
A
Q
P
R
V
C
D
A
E
Q
--
S
N
T
S
V
I
F
---
D
------------
R
R
A
I
L
K
V
F
R
R
V
---
S
---
S
G
----
I
---
N
P
D
I
E
L
N
R
V
L
T
R
A
-
G
N
-
P
H
V
A
R
L
L
G
A
Y
Q
--
F
G
-------
D
A
L
A
Y
A
L
G
M
V
T
E
Y
E
A
N
A
-
A
E
G
W
A
M
A
T
A
S
V
R
D
--------
L
F
A
E
G
D
L
Y
A
H
E
V
G
G
D
F
A
G
E
S
Y
R
L
G
E
A
V
A
S
V
H
A
T
L
A
D
-
S
---
L
G
T
A
--------
Q
-----
A
------
T
F
P
V
---
D
R
M
L
A
---
R
L
S
S
---------
T
V
-
A
----
V
V
--
P
---
E
---
L
-
R
-
E
-
Y
A
P
T
I
E
-------
Q
Q
-
F
Q
K
L
A
A
----
E
-
A
I
T
V
Q
R
V
H
G
D
L
H
-
L
G
Q
V
L
-
R
T
P
-------
E
-----
S
-
W
L
L
I
----
D
F
E
G
E
P
G
Q
P
L
D
E
R
R
A
P
D
S
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
Y
A
A
Y
G
P
L
V
----
D
Q
A
----
T
D
K
Q
L
A
A
R
A
R
E
W
V
E
R
N
R
A
-
A
F
C
D
G
Y
A
V
A
S
G
I
D
P
R
D
S
A
L
L
L
G
A
Y
E
L
D
K
A
V
Y
E
T
G
Y
E
T
-
R
-
H
R
P
G
W
L
P
I
P
L
R
S
I
A
R
L
T
A
--
3
PsiBlast_PDB
84.27
59%
-92
- C4 -
4U94
1
MAK_MYCVP
A:
[3-439]
----------------
L
A
F
G
D
W
I
V
H
R
R
W
Y
A
G
R
S
R
E
L
V
S
A
-
E
P
A
V
V
T
P
-
L
R
D
D
L
D
H
I
L
L
D
V
T
Y
T
D
G
T
V
E
R
Y
Q
L
V
V
R
W
A
D
S
P
V
A
G
F
G
E
A
A
T
I
G
T
A
L
G
PQ
G
E
R
I
A
Y
D
A
L
F
D
P
D
A
A
R
H
L
L
R
L
V
D
A
S
A
-----
T
V
A
D
L
R
F
T
R
E
P
G
A
T
L
P
--
L
Y
A
P
P
K
V
S
S
A
E
Q
--
S
N
T
S
V
I
F
---
G
------------
K
D
A
M
L
K
V
F
R
R
V
---
T
---
P
G
----
I
---
N
P
D
I
E
L
N
R
V
L
A
Q
A
-
G
N
-
R
H
V
A
R
L
L
G
S
F
E
T
S
W
A
G
P
G
---
T
D
R
C
A
--
L
G
M
V
T
A
F
A
A
N
S
-
A
E
G
W
D
M
A
T
A
S
A
R
E
--------
M
F
A
D
------
V
V
G
S
D
F
A
D
E
S
Y
R
L
G
N
A
V
A
S
V
H
A
T
L
A
E
-
A
---
L
G
T
S
--------
T
-----
E
------
P
F
P
V
---
D
T
V
L
A
---
R
L
Q
S
---------
A
A
-
R
----
S
A
--
P
---
E
---
L
-
A
-
G
-
R
A
A
A
V
E
-------
E
R
-
Y
R
R
L
D
G
----
R
-
A
I
T
V
Q
R
V
H
G
D
L
H
-
L
G
Q
V
L
-
R
T
P
-------
D
-----
D
-
W
L
L
I
----
D
F
E
G
E
P
G
Q
P
L
D
E
R
R
R
P
D
S
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
Y
A
A
Y
Q
K
L
V
ELAP
E
Q
D
----
A
D
G
R
L
A
D
R
A
R
N
W
V
D
R
N
S
A
-
A
F
C
A
G
Y
A
A
V
A
G
D
D
P
R
R
D
G
D
V
L
A
A
Y
E
L
D
K
A
V
Y
E
A
A
Y
E
A
-
R
-
F
R
P
S
W
L
P
I
P
M
R
S
I
D
R
I
----
14
HHSearch
84.05
61%
-91
- C4 -
4U98
3
MAK_MYCVP
A:
[2-441]
---------------
T
L
A
F
G
D
W
I
V
H
R
R
W
Y
A
G
R
S
R
E
L
V
S
A
-
E
P
A
V
V
T
P
L
R
D
-
D
L
D
H
I
L
L
D
V
T
Y
T
D
G
T
V
E
R
Y
Q
L
V
V
R
W
A
D
S
P
V
A
G
F
G
E
A
A
T
I
G
T
A
L
G
PQ
G
E
R
I
A
Y
D
A
L
F
D
P
D
A
A
R
H
L
L
R
L
V
D
A
S
A
-
T
V
A
----
D
L
R
F
T
R
E
P
G
A
T
L
P
--
L
Y
A
P
P
K
V
S
S
A
E
Q
--
S
N
T
S
V
I
F
---
G
------------
K
D
A
M
L
K
V
F
R
R
V
---
T
---
P
G
----
I
---
N
P
D
I
E
L
N
R
V
L
A
Q
A
-
G
N
-
R
H
V
A
R
L
L
G
S
F
E
--
T
S
W
A
G
P
G
---
T
D
R
C
A
L
G
M
V
T
A
F
A
A
N
S
-
A
E
G
W
D
M
A
T
A
S
A
R
E
--------
M
F
A
D
V
V
G
------
S
D
F
A
D
E
S
Y
R
L
G
N
A
V
A
S
V
H
A
T
L
A
E
-
A
---
L
G
T
S
--------
T
-----
E
------
P
F
P
V
---
D
T
V
L
A
---
R
L
Q
S
---------
A
A
-
R
----
S
A
--
P
---
E
---
L
-
A
-
G
-
R
A
A
A
V
E
-------
E
R
-
Y
R
R
L
D
G
----
R
-
A
I
T
V
Q
R
V
H
G
D
L
H
-
L
G
Q
V
L
-
R
T
P
-------
D
-----
D
-
W
L
L
I
----
D
F
E
G
E
P
G
Q
P
L
D
E
R
R
R
P
D
S
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
Y
A
A
Y
Q
K
L
V
----
E
L
A
PEQD
A
D
G
R
L
A
D
R
A
R
N
W
V
D
R
N
S
A
-
A
F
C
A
G
Y
A
A
V
A
G
D
D
P
R
R
D
G
D
V
L
A
A
Y
E
L
D
K
A
V
Y
E
A
A
Y
E
A
-
R
-
F
R
P
S
W
L
P
I
P
M
R
S
I
D
R
I
L
G
--
5
PsiBlast_PDB
83.71
59%
-91
- C4 -
4WZY
2
MAK_MYCVP
A:
[3-439]
----------------
L
A
F
G
D
W
I
V
H
R
R
W
Y
A
G
R
S
R
E
L
V
S
A
-
E
P
A
V
V
T
P
-
L
R
D
D
L
D
H
I
L
L
D
V
T
Y
T
D
G
T
V
E
R
Y
Q
L
V
V
R
W
A
D
S
P
V
A
G
F
G
E
A
A
T
I
G
T
A
L
G
PQ
G
E
R
I
A
Y
D
A
L
F
D
P
D
A
A
R
H
L
L
R
L
V
D
A
S
A
-----
T
V
A
D
L
R
F
T
R
E
P
G
A
T
L
P
--
L
Y
A
P
P
K
V
S
S
A
E
Q
--
S
N
T
S
V
I
F
---
G
------------
K
D
A
M
L
K
V
F
R
R
V
---
T
---
P
G
----
I
---
N
P
D
I
E
L
N
R
V
L
A
Q
A
-
G
N
-
R
H
V
A
R
L
L
G
S
F
E
T
S
W
A
G
P
G
---
T
D
R
C
A
--
L
G
M
V
T
A
F
A
A
N
S
-
A
E
G
W
D
M
A
T
A
S
A
R
E
--------
M
F
A
D
------
V
V
G
S
D
F
A
D
E
S
Y
R
L
G
N
A
V
A
S
V
H
A
T
L
A
E
-
A
---
L
G
T
S
--------
T
-----
E
------
P
F
P
V
---
D
T
V
L
A
---
R
L
Q
S
---------
A
A
-
R
----
S
A
--
P
---
E
---
L
-
A
-
G
-
R
A
A
A
V
E
-------
E
R
-
Y
R
R
L
D
G
----
R
-
A
I
T
V
Q
R
V
H
G
D
L
H
-
L
G
Q
V
L
-
R
T
P
-------
D
-----
D
-
W
L
L
I
----
D
F
E
G
E
P
G
Q
P
L
D
E
R
R
R
P
D
S
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
Y
A
A
Y
Q
K
L
V
ELAP
E
Q
D
----
A
D
G
R
L
A
D
R
A
R
N
W
V
D
R
N
S
A
-
A
F
C
A
G
Y
A
A
V
A
G
D
D
P
R
R
D
G
D
V
L
A
A
Y
E
L
D
K
A
V
Y
E
A
A
Y
E
A
-
R
-
F
R
P
S
W
L
P
I
P
M
R
S
I
D
R
I
----
4
PsiBlast_PDB
83.69
59%
-93
- C4 -
4U98
3
MAK_MYCVP
A:
[3-439]
----------------
L
A
F
G
D
W
I
V
H
R
R
W
Y
A
G
R
S
R
E
L
V
S
A
-
E
P
A
V
V
T
P
-
L
R
D
D
L
D
H
I
L
L
D
V
T
Y
T
D
G
T
V
E
R
Y
Q
L
V
V
R
W
A
D
S
P
V
A
G
F
G
E
A
A
T
I
G
T
A
L
G
PQ
G
E
R
I
A
Y
D
A
L
F
D
P
D
A
A
R
H
L
L
R
L
V
D
A
S
A
-----
T
V
A
D
L
R
F
T
R
E
P
G
A
T
L
P
--
L
Y
A
P
P
K
V
S
S
A
E
Q
--
S
N
T
S
V
I
F
---
G
------------
K
D
A
M
L
K
V
F
R
R
V
---
T
---
P
G
----
I
---
N
P
D
I
E
L
N
R
V
L
A
Q
A
-
G
N
-
R
H
V
A
R
L
L
G
S
F
E
T
S
W
A
G
P
G
---
T
D
R
C
A
--
L
G
M
V
T
A
F
A
A
N
S
-
A
E
G
W
D
M
A
T
A
S
A
R
E
--------
M
F
A
D
------
V
V
G
S
D
F
A
D
E
S
Y
R
L
G
N
A
V
A
S
V
H
A
T
L
A
E
-
A
---
L
G
T
S
--------
T
-----
E
------
P
F
P
V
---
D
T
V
L
A
---
R
L
Q
S
---------
A
A
-
R
----
S
A
--
P
---
E
---
L
-
A
-
G
-
R
A
A
A
V
E
-------
E
R
-
Y
R
R
L
D
G
----
R
-
A
I
T
V
Q
R
V
H
G
D
L
H
-
L
G
Q
V
L
-
R
T
P
-------
D
-----
D
-
W
L
L
I
----
D
F
E
G
E
P
G
Q
P
L
D
E
R
R
R
P
D
S
P
L
R
D
V
A
G
V
L
-----
R
S
F
E
Y
A
A
Y
Q
K
L
V
ELAP
E
Q
D
----
A
D
G
R
L
A
D
R
A
R
N
W
V
D
R
N
S
A
-
A
F
C
A
G
Y
A
A
V
A
G
D
D
P
R
R
D
G
D
V
L
A
A
Y
E
L
D
K
A
V
Y
E
A
A
Y
E
A
-
R
-
F
R
P
S
W
L
P
I
P
M
R
S
I
D
R
I
----
24
HHSearch
42.27
16%
-39
- C4 -
1ZYL
-
SRKA_ECOLI
A:
[31-282]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
L
N
-
S
Y
--
E
N
R
V
Y
Q
F
---
Q
D
EDR--------
R
R
F
V
V
K
F
Y
R
P
E
RWT
A
---
D
Q
----
I
---
L
E
E
H
Q
F
A
L
Q
L
V
N
D
-
E
V
-
P
-
V
A
A
P
V
A
F
-
N
--
G
Q
T
L
L
-----
N
H
Q
G
F
Y
F
A
V
F
P
S
V
G
G
R
-
Q
F
E
-------------------------------
A
D
N
I
D
Q
M
E
A
V
G
R
Y
L
G
R
M
H
Q
T
G
R
K
-
Q
---
L
F
I
H
--------
R
PT---
I
GL----
N
E
Y
L
---
I
E
P
R
K
---
L
F
E
D
---------
A
T
-
L
----
I
P
--
S
---
G
L--
K
-
A
-
A
-
F
L
K
A
T
D
-------
E
L
-
I
A
A
V
T
A
H
WR-
E
-
D
F
T
V
L
R
L
H
G
D
C
H
-
A
G
N
I
L
-
W
R
D
-------------
G
-
P
M
F
V
----
D
L
D
D
---------
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
-----
N
G
D
K
-----------------------------
A
E
Q
R
M
Q
L
E
-
T
I
I
E
A
Y
E
E
F
S
E
F
D
T
A
E
I
-
G
L
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
-----------------------
16
HHSearch
42.26
15%
-49
- C4 -
2PPQ
2
KHSE_AGRFC
A:
[25-277]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
S
Y
K
G
I
A
E
-----
N
S
N
F
L
L
---
H
T
T
K
---------
D
P
L
I
L
T
L
Y
E
K
-----K--
N
D
----
L
---
P
F
F
L
G
L
M
Q
H
L
A
A
K
-
G
L
-
S
-
C
P
L
P
L
P
R
K
D
--
G
E
L
L
G
-----
E
L
S
G
R
P
A
A
L
I
S
F
L
E
G
M
-
W
L
R
-------------------------------
K
P
E
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
E
G
-
F
---
E
I
K
R
--------
P
-----
N
------
A
L
S
V
---
D
G
W
K
V
---
L
W
D
K
---------
S
E
-
E
----
R
A
--
D
---
E
---
V
-
E
K
G
-
L
R
E
E
I
R
-------
P
E
-
I
D
Y
L
A
A
H
WP-
K
-
D
L
P
A
G
V
I
H
A
D
L
F
-
Q
D
N
V
F
-
F
L
G
-------
D
-----
E
L
S
G
L
I
----
D
F
Y
F
---------
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
-----
N
A
W
C
F
E
K
------------------------
D
G
A
Y
N
V
T
K
G
K
-
A
L
L
E
G
Y
Q
S
V
R
P
L
S
E
A
-
E
L
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
---------------------------
45
Fugue
41.92
16%
-26
- C1 -
4HU8
3
?
A:
[3-452]
N
E
I
T
L
T
I
G
Q
Q
K
D
L
A
S
M
V
P
-
A
K
F
A
G
Q
E
L
S
W
T
S
S
D
P
E
T
A
S
V
T
D
K
G
I
V
T
A
-
L
K
F
S
S
G
G
A
N
L
F
L
K
A
P
A
T
G
E
A
I
I
T
V
T
A
G
---
K
Q
S
H
S
V
K
V
I
T
T
V
K
G
K
----
E
D
I
E
K
L
P
P
L
K
D
H
F
K
D
Y
F
L
I
G
N
I
F
N
N
R
D
V
S
G
S
M
M
D
N
D
W
L
A
H
H
Y
A
I
L
T
P
EN
H
M
K
P
S
N
L
T
N
N
R
N
--
E
T
T
G
E
I
T
---
Y
------------
T
F
S
T
A
D
R
M
V
N
A
---
A
---
I
A
----
E
---
G
L
K
I
H
G
H
T
L
L
W
H
Q
-
Q
I
-
P
P
W
Q
R
S
M
E
S
------
A
A
K
D
A
A
L
S
V
M
K
K
Y
I
T
E
V
M
T
H
Y
K
G
K
-
I
Y
S
W
D
V
L
N
E
I
F
P
D
GRGDNWTT
A
M
R
P
E
N
P
W
F
K
S
I
G
S
D
F
V
Y
E
A
Y
L
A
A
R
Q
A
D
P
-
N
A
I
L
Y
Y
-
N
D
Y
N
M
D
Q
A
--------
G
-----
K
------
A
A
L
I
---
A
A
M
V
R
---
D
V
N
A
---------
K
Y
-
K
----
Q
A
YP
R
---
E
---
T
-
R
-
L
-
L
I
E
G
I
G
-------
M
Q
S
H
H
N
M
D
V
----
P
-
A
S
N
I
R
N
T
I
N
R
Y
R
E
L
G
V
K
I
-
S
V
S
-------
E
-----
L
-
D
I
L
C
MG
W
S
A
F
R
G
S
T
G
Q
G
A
D
K
D
D
M
T
I
A
T
N
R
N
I
L
D
-------
Q
A
Y
K
F
N
E
Y
M
K
L
Y
----
L
E
N
----
S
D
--
I
I
E
R
V
S
M
W
G
V
S
D
R
Y
-
S
W
------
R
S
G
G
L
P
----
L
L
F
D
A
D
N
K
A
K
P
A
Y
Y
S
F
V
R
A
-
R
-
E
D
Y
E
A
A
K
A
------------
39
Fugue
41.33
11%
-37
- C4 -
3I1A
2
?
A:
[3-330]
----------------------------------
K
Q
P
I
Q
-
A
Q
Q
L
I
E
L
-
L
K
V
H
Y
G
I
D
I
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
D
S
E
S
------------------------------------------------
K
S
Y
F
I
K
L
K
Y
G
Y
H
D
E
-------------------------------------------
I
N
L
S
I
I
R
L
L
---
H
---
D
S
----
G
---
I
K
E
I
I
F
P
I
H
T
L
E
A
-
K
L
-
F
Q
Q
L
K
H
F
K
I
I
A
--
Y
P
F
I
H
-----------
A
P
N
G
F
T
Q
N
L
T
-
G
K
Q
W
K
Q
L
G
K
V
L
R
Q
--------
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
I
E
F
-
D
---
N
S
D
D
--------
K
-----
L
------
T
A
A
F
---
K
S
F
F
N
---
Q
N
--------------------
S
--
A
---
A
---
I
-
H
-
R
-
L
V
D
T
S
E
-------
K
L
-
S
K
K
I
Q
P
----
D
-
L
D
K
Y
V
L
C
H
S
D
I
H
-
A
G
N
V
L
V
G
N
E
-------
E
-----
S
-
I
Y
I
I
----
D
W
D
-------
E
P
M
L
A
P
--
K
E
R
D
L
M
F
I
G
GGVGN
V
W
N
K
P
H
E
I
Q
Y
F
Y
----
E
G
Y
----
G
E
I
N
V
D
K
T
I
L
S
Y
Y
R
H
E
R
I
V
E
D
I
A
V
Y
G
Q
D
L
L
S
R
N
Q
N
N
Q
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
----------------
N
V
V
E
I
A
F
A
T
E
23
HHSearch
39.27
13%
-44
- C4 -
4DCA
2
?
A:
[40-307]
----------------------------------------------------------------------------------------------------------------------------------------------------
N
E
L
R
Y
L
S
S
G
D
--
D
S
D
T
F
L
C
---
N
------------
E
Q
Y
V
V
K
V
P
K
R
D
---
S
V
R
-
I
S
----
Q
---
K
R
E
L
E
L
Y
R
F
L
E
N
C
-
K
L
S
Y
Q
I
P
A
V
V
Y
Q
----------
S
-------
D
R
F
N
I
M
K
Y
I
K
G
E
-
R
I
T
Y
E
Q
-
Y
H
K
L
---------------------
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
-
C
---
S
V
S
L
F
S
D
-----
A
-----
L
------
V
N
K
K
---
D
K
F
L
Q
---
D
K
K
L
---------
L
I
-
S
----
I
L
--
E
K
E
Q
L
---
L
T
D
-
E
-
M
L
E
H
I
E
-------
T
I
-
Y
E
N
I
L
S
NAV-
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
-
A
N
N
M
I
-
F
R
N
-------
N
-----
R
L
F
G
V
I
----
D
F
G
D
---------
F
N
V
G
D
P
D
N
D
F
L
C
L
L
-----
D
C
S
T
----------------------------
D
D
F
G
K
E
F
G
R
-
K
V
L
K
Y
Y
Q
H
K
A
P
E
---
V
A
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
-
K
D
R
E
M
L
I
K
D
V
----------
34
HHSearch
39.17
14%
-48
* C4 *
3TDW
5
?
A:
[21-293]
---------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
S
V
E
S
L
G
E
G
F
--
R
N
Y
A
I
L
V
---
N
------------
G
D
W
V
F
R
F
P
K
S
Q
---
Q
G
A
-
D
E
----
L
---
N
K
E
I
Q
L
L
P
L
L
V
G
C
V
K
V
--
N
I
P
Q
Y
V
Y
I
G
K
--
R
----------
S
D
G
N
P
F
V
G
Y
R
K
V
Q
G
Q
-
I
L
G
-
E
D
G
M
A
V
L
---------------------
P
D
D
A
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
-
T
---
A
I
S
A
G
V
------
P
-----
V
T
N
L
---
K
N
K
I
---
L
L
L
S
E
---
A
V
E
D
---------
Q
V
-
F
--------
P
---
L
---
L
-
D
-
E
S
L
R
D
Y
L
T
-------
L
R
-
F
Q
S
Y
M
T
HPV-
Y
T
R
Y
T
P
R
L
I
H
G
D
L
S
-
P
D
H
F
L
-
T
N
L
-------
N
SRQTP
L
-
T
G
I
I
----
D
F
G
D
---------
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
-----
E
D
C
G
---------------------------------
E
L
F
T
-
R
Q
V
M
A
Y
R
G
E
V
D
L
--
D
T
H
I
R
K
V
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
L
-
R
A
R
D
Q
D
W
I
S
E
G
L
E
L
L
-------
22
HHSearch
39.10
13%
-45
- C4 -
4R78
2
?
A:
[40-275]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
S
V
E
Q
L
-
G
G
M
--
T
N
Q
N
Y
L
A
K
T
T
N
------------
K
Q
Y
I
V
K
F
F
G
K
G
---
T
EKL
I
N
----
R
---
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
---
D
V
K
N
Y
L
F
D
I
---------------
E
A
G
I
K
V
N
E
Y
I
E
S
A
I
T
L
D
------
S
------------------------
T
S
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
-
L
---
R
G
E
F
--------
A
-----
P
------
F
E
E
I
---
K
K
Y
E
S
---
L
I
E
E
---------
Q
I
-
P
-----
Y
--
A
-------------
N
Y
E
S
V
R
-------
N
A
-
V
F
S
L
E
K
R
L
A
D
L
-
G
V
D
R
K
S
C
H
I
D
L
V
-
P
E
N
F
I
-
E
S
P
Q------
G
-----
R
-
L
Y
L
I
----
D
W
E
Y
---------
S
S
M
N
D
P
M
W
D
L
A
A
L
F
-----
L
E
S
E
F
------------------------------
T
S
Q
E
E
E
-
T
F
L
S
H
Y
E
S
D
Q
T
P
--
V
S
-
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
------------------------
28
HHSearch
38.94
15%
-47
- C4 -
5FTG
10
?
A:
[32-308]
----------------------------------------------------------------------------------------------------------------------------------------------------
F
H
I
S
V
I
R
G
G
L
--
S
N
M
L
F
Q
C
---
S
L
PDTTATLGDEP
R
K
V
L
L
R
L
Y
G
----------------E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
---
G
P
K
L
Y
G
I
F
--------------
P
---
Q
G
R
L
E
Q
F
I
P
S
R
-
R
L
D
----
T
E
E
------------------------
L
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
M
P
-
F
---
N
K
E
P
--------
K
W----
L
------
F
G
T
M
---
E
K
Y
L
K
---
E
V
L
R
---------
I
K
-
F
TE
E
S
R
I
--
K
---
K
---
L
-
H
-
K
L
L
S
Y
N
L
P
-------
L
E
-
L
E
N
L
R
S
L
L
E
-
S
T
P
S
P
V
V
F
C
H
N
D
C
Q
-
E
G
N
I
L
-
L
L
E
GRENSEK
Q
-----
K
-
L
M
L
I
----
D
F
E
Y
---------
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
-----
C
E
W
M
Y
D
Y
S
Y
E
K
------------
Y
P
F
F
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
-
H
F
I
S
S
Y
L
P
A
F
Q
-------------------------------------------------
26
HHSearch
38.18
13%
-41
- C4 -
3JR1
3
?
A:
[39-285]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
H
K
E
K
L
Y
S
G
E
--
M
N
E
I
W
L
I
---
N
DE
V
---------
Q
T
V
F
V
K
I
N
E
R
S
Y--
R
---
S
M
----
F
---
R
A
E
A
D
Q
L
A
L
L
A
K
T
-
N
S
-
I
N
V
P
L
V
Y
G
I
G
N
--
S
-----------
Q
G
H
S
F
L
L
L
E
A
L
N
K
S
-
K
N
----------------------------------
K
Q
S
S
F
T
I
F
A
E
K
I
A
Q
L
H
Q
I
Q
G
P
D
K
---
Y
G
L
D
F
D
T
W
L
GP
I
Y
Q
P
N
D
W
Q
------
T
S
W
A
---
K
F
F
S
E
N--
R
I
G
W
---------
Q
L
-
Q
----
I
C
--
K
---
E
K
GL
I
-
F
-
G
-
N
I
D
L
I
V
-------
Q
I
-
V
A
D
T
L
S
----
K
H
N
P
K
P
S
I
L
H
G
N
L
W
-
I
E
N
C
I
-
Q
V
D
-------
D
-----
K
-
I
F
V
C
----
N
-
P
A
---------
C
Y
W
G
D
R
E
C
D
I
A
F
S
S
------
L
F
E
---------------------------------
P
F
P
T
-
N
F
Y
Q
R
Y
N
E
I
Y
P
L
E
E
-
G
Y
L
E
R
K
L
I
Y
Q
L
Y
Y
L
L
N
F
S
---------------------------
25
HHSearch
37.78
13%
-26
- C4 -
4OCV
5
?
A:
[42-299]
----------------------------------------------------------------------------------------------------------------------------------------------------
D
S
I
E
P
Y
G
D
G
H
--
I
N
T
T
Y
L
V
---
T
T
D
G
---------
P
R
Y
I
L
Q
R
M
N
T
G
---
I
F--
P
D
T
V
N
L
M
---
R
N
V
E
L
V
T
S
T
L
K
A
Q
-
G
K
-
E
-
T
L
D
I
V
R
T
T
S
--
G
D
T
W
A
-----
E
I
D
G
G
A
W
R
V
Y
K
F
I
E
H
T
-
M
S
Y
N
-----------------------------
L
V
P
N
P
D
V
F
R
E
A
G
R
A
F
G
D
F
Q
N
F
L
S
G
-
F
---
D
A
N
Q
--------
L
-----
T
ETI---
A
H
F
H
D
T
P
H
R
F
E
D
---
F
K
K
A
---------
L
A
-
A
DELG
R
A
--
A
---
G
---
C
-
G
-
P
-
E
I
E
F
Y
L
S
H
ADQYA
V
V
-
M
D
G
L
R
D
----
G
-
S
I
P
L
R
V
T
H
N
D
T
K
-
L
N
N
I
L
-
M
D
A
TTG----
K
-----
A
-
R
A
I
I
----
D
L
D
T
---------
I
M
P
G
S
M
L
F
D
F
G
D
S
I
-----
R
F
G
A
S
T
A
L
E
----------------
D
E
R
D
L
D
K
V
H
F
S
T
E
L
F
R
-
A
Y
T
E
G
F
V
G
E
---------------------------------------------------
18
HHSearch
37.15
13%
-31
- C4 -
3I1A
2
?
A:
[24-292]
----------------------------------------------------------------------------------------------------------------------------------------------------
H
T
A
Q
F
I
Q
G
G
A
DT
N
A
F
A
Y
Q
A
D
S
E
S
------------
K
S
Y
F
I
K
L
K
Y
G
Y
---
H
---------
D
---
E
I
N
L
S
I
I
R
L
L
H
D
S
-
G
I
-
K
E
I
I
F
P
I
H
T
L
E
--
A
K
L
F
Q
Q
-----
L
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
-
N
G
F
T
----
Q
-------------------------
N
L
T
G
K
Q
W
K
Q
L
G
K
V
L
R
Q
I
H
E
T
S
V
P
-
I
---
S
I
Q
Q
--------
Q
-----
L
RKEIYS
P
K
W
R
---
E
I
V
R
S
F
Y
N
Q
I
E
F
DNSDD
K
L
T
A
A
F
K
S
----
F
F
--
N
---
Q
---
N
-
S
-
A
-
A
I
H
R
L
V
-------
D
T
-
S
E
K
L
S
K
K
IQ-
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
-
A
G
N
V
L
-
V
G
N
E------
E
-----
S
-
I
Y
I
I
----
D
W
D
E
---------
P
M
L
A
P
K
E
R
D
L
M
F
I
G
-----
G
G
V
G
N
---------------------------
V
W
N
K
P
H
E
I
Q
-
Y
F
Y
E
G
Y
G
E
I
N
V
-
D
----
K
T
I
L
S
Y
Y
R
H
E
R
I
V
E
D
I
A
V
Y
------------------------