@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0155: (2016-04-20 )
MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGERALLPDELYTAVGASIGDAWAADVVVKVAPPTAAEVGRLRGGQTLIGFLAPRNADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPMLTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLDLGISASGEGGYARELTDDERAQQQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGGNCELTEPGRTVVKHDVTIAAPLNLPATMPEHASELYSKNITALLDLLIKDGRLAPDFDDEVIAQSCVTRGKDS
Atome Classification :
(43 SA)
........---.10........20........30........40........50........60....---..----..-70----.........80......-----..90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220--.........230.......240.......250.......260.......270.......280.......290.......300..-....-.310.......320.......330.......340-...--.-....350.......360....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTDPQTQS---
T
R
V
G
V
V
AESGPDE
R
R
V
A
L
V
P
K
A
V
A
S
L
VNR
G
V
A
V
V
V
EAGAGERAL
L
P
D
E
L
Y
T
A
V
GASI---GD----AW-A-----A
D
V
V
V
K
VAPP
T
A
A
E
V
G
R-----LRGG
Q
T
L
I
G
F
LAPRNADN
S
I
G
A
L
T
Q
A
G
V
Q
A
F
A
L
E
AIPR
I
S
R
A
Q
V
M
D
A
L
SSQANVSG
Y
K
A
V
L
L
AASES
T
R
F
F
P
M
L
TTAAGTVK
P
A
T
V
L
V
L
G
V
G
V
A
G
L
Q
A
L
A
T
A
K
R
LGARTTGYDVR
P
E
V
A
D
Q
V
R
S
V
G
A
Q
W
L
D
LG----ISASGEGGYARELT
D
D
E
R
A
Q
Q
Q
K
A
L
E
E
A
ISG
F
D
V
V
I
T
T
ALVPGRPA
P
T
L
V
T
A
A
A
V
E
AMKPG
S
V
V
V
D
LAGETGGN
C
E
LTEPG
R
T
V
-
V
K
H
D
-
V
T
I
AAPLNLPAT
M
P
E
H
A
S
E
L
Y
S
K
N
I
T
A
L
L
D
L
L
I--KDG--R-LAPDF
D
D
E
V
I
A
Q
S
C
V
TRGKDS
80
HHSearch
95.50
72%
-114
- C3 -
3P2Y
6
?
A:
[20-377]
-----
G
S
M
---
T
L
I
G
V
P
R
E
S
A
E
G
E
R
R
V
A
L
V
P
K
V
V
E
K
L
S
A
R
G
L
E
V
V
V
E
S
A
A
G
A
G
A
L
F
S
D
A
D
Y
E
R
A
G
A
T
I
---
G
D
----
P
W
-
P
-----
A
D
V
V
V
K
V
N
P
P
T
S
D
E
I
S
Q
-----
L
K
P
G
S
V
L
I
G
F
L
A
P
R
T
Q
P
E
L
A
S
R
L
R
I
A
D
V
T
A
F
A
M
E
S
I
P
R
I
S
R
A
Q
T
M
D
A
L
S
S
Q
A
N
V
A
G
Y
K
A
V
L
L
G
A
S
L
S
T
R
F
V
P
M
L
T
T
A
A
G
T
V
K
P
A
S
A
L
V
L
G
V
G
V
A
G
L
Q
A
L
A
T
A
K
R
L
G
A
K
T
T
G
Y
D
V
R
P
E
V
A
E
Q
V
R
S
V
G
A
Q
W
L
D
L
G
-----------------
S
E
A
E
R
A
Q
Q
Q
Q
A
L
E
D
A
I
T
K
F
D
I
V
I
T
T
A
L
V
P
G
R
P
A
P
R
L
V
T
A
A
A
A
T
G
M
Q
P
G
S
V
V
V
D
L
A
G
E
T
G
G
N
C
E
L
T
E
P
G
R
T
I
-
V
H
H
G
-
V
T
I
T
S
P
L
N
L
P
A
T
M
P
E
H
A
S
E
L
Y
A
K
N
V
T
A
L
L
D
L
L
L
--
T
D
D
--
G
-
V
A
P
D
F
T
D
E
I
V
A
A
S
C
I
T
R
T
---
1
PsiBlast_PDB
94.97
72%
-116
- C3 -
3P2Y
6
?
A:
[20-376]
--------GSM
T
L
I
G
V
P
R
E
S
A
E
G
E
R
R
V
A
L
V
P
K
V
V
E
K
L
S
A
R
G
L
E
V
V
V
E
S
A
A
G
A
G
A
L
F
S
D
A
D
Y
E
R
A
G
A
T
I
---
G
D
----
P
W
-
P
-----
A
D
V
V
V
K
V
N
P
P
T
S
D
E
I
S
Q
-----
L
K
P
G
S
V
L
I
G
F
L
A
P
R
T
Q
P
E
L
A
S
R
L
R
I
A
D
V
T
A
F
A
M
E
S
I
P
R
I
S
R
A
Q
T
M
D
A
L
S
S
Q
A
N
V
A
G
Y
K
A
V
L
L
G
A
S
L
S
T
R
F
V
P
M
L
T
T
A
A
G
T
V
K
P
A
S
A
L
V
L
G
V
G
V
A
G
L
Q
A
L
A
T
A
K
R
L
G
A
K
T
T
G
Y
D
V
R
P
E
V
A
E
Q
V
R
S
V
G
A
Q
W
L
D
L
G
-----------------
S
E
A
E
R
A
Q
Q
Q
Q
A
L
E
D
A
I
T
K
F
D
I
V
I
T
T
A
L
V
P
G
R
P
A
P
R
L
V
T
A
A
A
A
T
G
M
Q
P
G
S
V
V
V
D
L
A
G
E
T
G
G
N
C
E
L
T
E
P
G
R
T
I
-
V
H
H
G
-
V
T
I
T
S
P
L
N
L
P
A
T
M
P
E
H
A
S
E
L
Y
A
K
N
V
T
A
L
L
D
L
L
L
--
T
D
D
--
G
-
V
A
P
D
F
T
D
E
I
V
A
A
S
C
I
T
R
----
85
HHSearch
86.67
51%
-109
- C3 -
4IZH
9
?
A:
[7-368]
-------
M
---
V
T
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGE-
L
L
K
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
--------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
E
G
E
-
23
PsiBlast_CBE
85.96
51%
-112
- C3 -
4J1T
4
?
D:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
E
G
E
G
G
Y
A
R
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
9
PsiBlast_PDB
85.84
45%
-103
- C3 -
1L7E
1
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
SQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
D------
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
22
PsiBlast_CBE
85.11
51%
-111
- C3 -
4J1T
2
?
E:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
E
G
E
G
G
Y
A
R
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
38
PsiBlast_CBE
84.44
45%
-105
- C3 -
1L7E
1
PNTAA_RHORT
D:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
----------
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
3
PsiBlast_PDB
84.35
51%
-112
- C3 -
4IZH
9
?
A:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
--------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
25
PsiBlast_CBE
84.28
51%
-105
- C3 -
4J16
4
?
B:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
E
G
----
A
R
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
6
PsiBlast_PDB
84.20
51%
-110
- C3 -
4J1T
2
?
A:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
E
------
R
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
16
PsiBlast_PDB
84.16
45%
-103
- C3 -
1PTJ
3
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
---------
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
21
PsiBlast_CBE
84.06
51%
-108
- C3 -
4O9U
1
?
F:
[13-368]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
E
G
----
A
R
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
5
PsiBlast_PDB
84.05
51%
-105
- C3 -
4J16
4
?
A:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
E
G
E
G
G
Y
A
R
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
26
PsiBlast_CBE
83.93
51%
-111
- C3 -
4IZI
2
?
B:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
E
-------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
27
PsiBlast_CBE
83.92
51%
-110
- C3 -
4IZH
8
?
B:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
---------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
24
PsiBlast_CBE
83.86
51%
-109
- C3 -
4J1T
2
?
B:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
---------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
8
PsiBlast_PDB
83.79
45%
-105
- C3 -
1HZZ
1
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
QALSQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
---------
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
7
PsiBlast_PDB
83.70
45%
-106
- C3 -
1L7D
-
PNTAA_RHORT
B:
[402-770]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
-------------------------
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
81
HHSearch
83.58
41%
-107
- C3 -
1X13
-
PNTA_ECOLI
A:
[1001-1365]
-----------
G
R
I
G
I
P
R
E
R
L
T
N
E
T
R
V
A
A
T
P
K
T
V
E
Q
L
L
K
L
G
F
T
V
A
V
E
S
G
A
G
Q
L
A
S
F
D
D
K
A
F
V
Q
A
G
A
E
I
---
V
E
G
NS-
V
W
-
Q
-----
S
E
I
I
L
K
V
N
A
P
L
D
D
E
I
A
L
-----
L
N
P
G
T
T
L
V
S
F
I
W
P
A
Q
N
P
E
L
M
Q
K
L
A
E
R
N
V
T
V
M
A
M
D
S
V
P
R
I
S
R
A
Q
S
L
D
A
L
S
S
M
A
N
I
A
G
Y
R
A
I
V
E
A
A
H
E
F
G
R
F
F
T
G
Q
I
T
A
A
G
K
V
P
P
A
K
V
M
V
I
G
A
G
V
A
G
L
A
A
I
G
A
A
N
S
L
G
A
I
V
R
A
F
D
T
R
P
E
V
K
E
Q
V
Q
S
M
G
A
E
F
L
E
L
----------
G
D
G
Y
A
K
V
M
S
D
A
F
I
K
A
E
M
E
L
F
A
A
Q
A
K
E
V
D
I
I
V
T
T
A
L
I
P
G
K
P
A
P
K
L
I
T
R
E
M
V
D
S
M
K
A
G
S
V
I
V
D
L
A
A
Q
N
G
G
N
C
E
Y
T
V
P
G
E
I
F
T
T
E
N
G
-
V
K
V
I
G
Y
T
D
L
P
G
R
L
P
T
Q
S
S
Q
L
Y
G
T
N
L
V
N
L
L
K
L
L
C
--
K
E
K
DG
N
-
I
T
V
D
F
D
D
V
V
I
R
G
V
T
V
I
R
A
G
E
-
17
PsiBlast_PDB
83.55
44%
-105
- C3 -
2FRD
1
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
A
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
----------
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
4
PsiBlast_PDB
83.20
51%
-111
- C3 -
4IZI
5
?
A:
[10-365]
-------------
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
---
V
E
RGEL
L
K
-
G
-----
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
I
Q
A
-----
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
----
I
S
A
E
-------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
-
E
V
R
G
-
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
--
E
K
G
--
A
-
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
----
47
PsiBlast_CBE
82.85
41%
-109
- C3 -
1X14
1
PNTA_ECOLI
B:
[9-369]
------------
R
I
G
I
P
R
E
R
L
T
N
E
T
R
V
A
A
T
P
K
T
V
E
Q
L
L
K
L
G
F
T
V
A
V
E
S
G
A
G
Q
L
A
S
F
D
D
K
A
F
V
Q
A
G
A
E
I
V
E
G
N
S
----
V
W
-
Q
-----
S
E
I
I
L
K
V
N
A
P
L
D
D
E
I
A
L
-----
L
N
P
G
T
T
L
V
S
F
I
W
P
A
Q
N
P
E
L
M
Q
K
L
A
E
R
N
V
T
V
M
A
M
D
S
V
P
R
I
S
R
A
Q
S
L
D
A
L
S
S
M
A
N
I
A
G
Y
R
A
I
V
E
A
A
H
E
F
G
R
F
F
T
G
Q
I
T
A
A
G
K
V
P
P
A
K
V
M
V
I
G
A
G
V
A
G
L
A
A
I
G
A
A
N
S
L
G
A
I
V
R
A
F
D
T
R
P
E
V
K
E
Q
V
Q
S
M
G
A
E
F
L
E
L
D
----------------
M
S
D
A
F
I
K
A
E
M
E
L
F
A
A
Q
A
K
E
V
D
I
I
V
T
T
A
L
I
P
G
K
P
A
P
K
L
I
T
R
E
M
V
D
S
M
K
A
G
S
V
I
V
D
L
A
A
Q
N
G
G
N
C
E
Y
T
V
P
G
E
I
F
-
T
T
E
N
G
V
K
V
I
G
Y
T
D
L
P
G
R
L
P
T
Q
S
S
Q
L
Y
G
T
N
L
V
N
L
L
K
L
L
C
KE
K
D
G
--
N
-
I
T
V
D
F
D
D
V
V
I
R
G
V
T
V
I
R
----
18
PsiBlast_PDB
82.42
44%
-103
- C3 -
2FSV
2
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
SQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
N
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
------------
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
29
PsiBlast_CBE
82.31
45%
-98
- C3 -
2OO5
6
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
QALSQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
DEAM
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
15
PsiBlast_PDB
82.04
45%
-102
- C3 -
2OOR
1
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
D
E
A
M
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
40
PsiBlast_CBE
81.98
45%
-108
- C3 -
1PTJ
3
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
DEAM---------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
28
PsiBlast_CBE
81.98
45%
-104
- C3 -
2OOR
3
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
SQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
-----------------
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
12
PsiBlast_PDB
81.98
45%
-103
- C3 -
1U2G
1
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
SQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
D
E
A
M
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
14
PsiBlast_PDB
81.96
45%
-101
- C3 -
2OO5
5
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
SQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
D
E
A
M
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
10
PsiBlast_PDB
81.96
45%
-103
- C3 -
1U28
1
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
DEAM
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
19
PsiBlast_PDB
81.90
44%
-105
- C3 -
1NM5
1
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
SQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
N
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
--------------
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
42
PsiBlast_CBE
81.64
44%
-109
- C3 -
2FSV
3
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
N
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
-------------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
46
PsiBlast_CBE
81.63
41%
-111
- C3 -
1X15
1
PNTA_ECOLI
B:
[9-369]
------------
R
I
G
I
P
R
E
R
L
T
N
E
T
R
V
A
A
T
P
K
T
V
E
Q
L
L
K
L
G
F
T
V
A
V
E
S
G
A
G
Q
L
A
S
F
D
D
K
A
F
V
Q
A
G
A
E
I
V
E
G
N
S
----
V
W
-
Q
-----
S
E
I
I
L
K
V
N
A
P
L
D
D
E
I
A
L
-----
L
N
P
G
T
T
L
V
S
F
I
W
P
A
Q
N
P
E
L
M
Q
K
L
A
E
R
N
V
T
V
M
A
M
D
S
V
P
R
I
S
R
A
Q
S
L
D
A
L
S
S
M
A
N
I
A
G
Y
R
A
I
V
E
A
A
H
E
F
G
R
F
F
T
G
Q
I
T
A
A
G
K
V
P
P
A
K
V
M
V
I
G
A
G
V
A
G
L
A
A
I
G
A
A
N
S
L
G
A
I
V
R
A
F
D
T
R
P
E
V
K
E
Q
V
Q
S
M
G
A
E
F
L
E
L
D
-----------------
S
D
A
F
I
K
A
E
M
E
L
F
A
A
Q
A
K
E
V
D
I
I
V
T
T
A
L
I
P
G
K
P
A
P
K
L
I
T
R
E
M
V
D
S
M
K
A
G
S
V
I
V
D
L
A
A
Q
N
G
G
N
C
E
Y
T
V
P
G
E
I
F
-
T
T
E
N
G
V
K
V
I
G
Y
T
D
L
P
G
R
L
P
T
Q
S
S
Q
L
Y
G
T
N
L
V
N
L
L
K
L
L
C
KE
K
D
G
--
N
-
I
T
V
D
F
D
D
V
V
I
R
G
V
T
V
I
R
----
39
PsiBlast_CBE
81.62
45%
-106
- C3 -
1HZZ
1
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
DEAM---------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
20
PsiBlast_PDB
81.50
44%
-106
- C3 -
2FR8
1
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
A
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
-------------------------
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
11
PsiBlast_PDB
81.36
45%
-102
- C3 -
1U2D
1
PNTAA_RHORT
A:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
SQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
D
E
A
M
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
43
PsiBlast_CBE
81.32
44%
-107
- C3 -
1NM5
3
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
SQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
N
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
--------------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
36
PsiBlast_CBE
81.19
45%
-96
- C3 -
1U2D
3
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
QALSQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
DEAM
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
35
PsiBlast_CBE
81.02
45%
-108
- C3 -
1U2G
3
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
----------------------
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
37
PsiBlast_CBE
81.01
45%
-108
- C3 -
1U28
4
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
Q
A
L
SQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
---------------------
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
---
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
41
PsiBlast_CBE
80.88
44%
-105
- C3 -
2FRD
2
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
QALSQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
A
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
D------------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
44
PsiBlast_CBE
80.55
44%
-104
- C3 -
2FR8
1
PNTAA_RHORT
B:
[2-370]
------------
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
---
A
S
----
T
A
-
A
QALSQ
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
E
G
T
DEVAL
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
A
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
------------------------
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
-
V
K
H
G
-
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
D-
K
D
T
--
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
----
45
PsiBlast_CBE
77.51
41%
-94
- C3 -
2BRU
2
PNTA_ECOLI
B:
[9-369]
------------
R
I
G
I
P
R
E
R
L
T
N
E
T
R
V
A
A
T
P
K
T
V
E
Q
L
L
K
L
G
F
T
V
A
V
E
S
G
A
G
Q
L
A
S
F
D
D
K
A
F
V
Q
A
G
A
E
I
VEG
N
S
----
V
W
-
Q
-----
S
E
I
I
L
K
V
N
A
P
L
D
D
E
I
A
L
-----
L
N
P
G
T
T
L
V
S
F
I
W
P
A
Q
N
P
E
L
M
Q
K
L
A
E
R
N
V
T
V
M
A
M
D
S
V
P
R
I
S
R
A
Q
S
L
D
A
L
S
S
M
A
N
I
A
G
Y
R
A
I
V
E
A
A
H
E
F
G
R
F
F
T
G
Q
I
T
A
A
G
K
V
P
P
A
K
V
M
V
I
G
A
G
V
A
G
L
A
A
I
G
A
A
N
S
L
G
A
I
V
R
A
F
D
T
R
P
E
V
K
E
Q
V
Q
S
M
G
A
E
F
L
E
L
D
----------------
M
S
D
A
F
I
K
A
E
M
E
L
F
A
A
Q
A
K
E
V
D
I
I
V
T
T
A
L
I
P
G
K
P
A
P
K
L
I
T
R
E
M
V
D
S
M
K
A
G
S
V
I
V
D
L
A
A
Q
N
G
G
N
C
E
Y
T
V
P
G
E
I
F
-
T
T
E
N
G
V
K
V
I
G
Y
T
D
L
P
G
R
L
P
T
Q
S
S
Q
L
Y
G
T
N
L
V
N
L
L
K
L
L
C
KE
K
D
G
--
N
-
I
T
V
D
F
D
D
V
V
I
R
G
V
T
V
I
R
----