@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0157: (2016-04-20 )
MNLHYLVEILYIISFSLFIYGLMGLTGPKTAVRGNLIAAAGMTIAVAATLVMIRHTSQWPLIIAGLVVGVVLGVPPARLTKMTAMPQLVAFFNGVGGGTVALIALSEFIDTTGFSAFQHGESPTVHIVVASLFAAIIGSISFWGSIVAFGKLQEIISGRPIGLGKAQQPINLLLLAVAVAAAVVIGLHAHPGSGGVALWWMIGLLVAAGVLGLMVVLPIGGADMPVVISMLNAMTGLSAAAAGLALNNTAMIVAGMIVGASGSILTNLMAKAMNRSIPAIVAGGFGGGGVAPSGGGDDKHVKATSAADAAIQMAYANQVIVVPGYGLAVAQAQHAVKDLATLLEDRGVPVKYAIHPVAGRMPGHMNVLLAEAEVDYDAMKDMDDINDEFARTDVTIVIGANDVTNPAARNETSSPIYGMPILNVDKSRSVIVLKRSMNSGFAGIDNPLFYADGTTMLFGDAKKSVTEVSEELKAL
Atome Classification :
(38 SA)
.........10........20........30........40........50........60-----.........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200----.........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.....---..310.-......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
L
H
Y
L
V
E
I
L
Y
I
I
S
F
S
L
F
I
Y
G
L
MGLTGPKTAVRG
N
L
I
AAAG
M
T
I
A
V
A
A
T
L
V
M
I
RHTSQW
P
------
L
I
I
A
G
L
V
V
G
V
VLGV
P
P
A
R
L
T
K
M
T
A
M
P
Q
L
V
A
F
F
NGVGG
G
T
V
A
L
I
A
L
S
E
F
I
DTTGF
S
A
FQHGES
P
T
V
H
I
V
V
A
S
L
F
A
A
I
I
G
S
I
S
F
W
G
S
I
V
A
F
G
K
L
Q
E
I
ISGRPIGLGKAQQ
P
I
N
L
L
L
L
A
V
A
V
A
A
A
V
V
I
G
L
HAHPGSG
G
V
A
L
W
W
------
M
I
G
L
L
V
A
A
G
V
L
G
L
M
V
V
L
PIGGA
D
M
P
V
V
I
S
M
L
N
A
M
T
G
L
S
A
A
A
AGLALNNT
A
M
I
V
A
G
M
I
VGA
S
G
S
I
L
T
N
L
M
A
K
A
MNRSI
P
A
I
V
AGGFGGGGVAPSGGGDD
K
H
V
K
ATSAA---
D
A
A
I
Q
M
-
A
YA
N
Q
V
I
V
VPGY
G
L
A
V
A
Q
A
Q
H
A
V
K
D
L
A
T
L
L
EDRGV
P
V
K
Y
A
I
H
P
V
AGRMPGH
M
N
V
L
L
A
EAEV
D
Y
D
A
M
K
D
M
D
D
I
N
D
E
FART
D
V
T
I
V
IGANDVTNPAARNETSSPIYG
M
P
ILNVDKS
R
S
V
I
V
L
K
RSMNSGFAGIDN
P
L
F
YADG
T
T
M
L
FGDA
K
K
S
V
T
E
V
S
E
E
L
KAL
1
PsiBlast_PDB
88.78
46%
-138
- C6 -
4O9U
1
?
B:
[3-450]
-----
L
I
Q
A
A
Y
F
V
V
A
I
L
F
I
V
G
L
K
R
M
A
H
P
T
T
A
K
S
G
I
V
W
A
G
W
G
M
V
L
A
V
L
A
T
F
F
-------
W
P
GMGN
F
A
L
I
L
L
A
L
L
L
G
S
V
V
A
W
W
A
A
V
R
V
A
M
T
D
M
P
Q
M
V
A
I
Y
N
G
M
G
G
G
A
A
A
T
I
A
A
V
E
L
L
K
----
G
A
F
E
N
-----
T
G
L
M
A
L
A
I
L
G
G
L
I
G
S
V
A
F
T
G
S
L
I
A
F
A
K
L
Q
G
I
M
K
S
R
P
I
-
L
F
P
G
Q
K
A
V
N
A
L
V
L
A
L
T
V
----
V
I
G
L
---------
S
L
L
W
NDA
T
A
S
I
V
L
F
F
L
L
A
L
L
F
G
V
L
M
T
L
P
I
G
G
G
D
M
P
V
A
I
S
F
Y
N
A
F
T
G
M
A
V
G
F
E
G
F
A
V
G
N
P
A
L
M
V
A
G
T
L
V
G
A
A
G
T
L
L
T
V
L
M
A
R
A
M
N
R
S
V
W
S
V
L
V
G
G
-------------
K
G
S
L
K
P
I
D
V
E
---
D
A
A
V
M
L
-
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
-
R
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
R
L
32
HHSearch
88.04
48%
-135
* C7 *
4O9U
1
?
B:
[2-450]
----
D
L
I
Q
A
A
Y
F
V
V
A
I
L
F
I
V
G
L
K
R
M
A
H
P
T
T
A
K
S
G
I
V
W
A
G
W
G
M
V
L
A
V
L
A
T
F
F
W
P
G
-
M
G
N
F
A
------
L
I
L
L
A
L
L
L
G
S
V
V
A
W
W
A
A
V
R
V
A
M
T
D
M
P
Q
M
V
A
I
Y
N
G
M
G
G
G
A
A
A
T
I
A
A
V
E
L
L
K
G
A
F
E
---------
N
T
G
L
M
A
L
A
I
L
G
G
L
I
G
S
V
A
F
T
G
S
L
I
A
F
A
K
L
Q
G
I
M
K
S
R
P
I
L
F
-
P
G
Q
K
A
V
N
A
L
V
L
A
L
T
V
V
I
G
L
S
L
L
W
N
D
-------
A
T
A
S
------
I
V
L
F
F
L
L
A
L
L
F
G
V
L
M
T
L
P
I
G
G
G
D
M
P
V
A
I
S
F
Y
N
A
F
T
G
M
A
V
G
F
E
G
F
A
V
G
N
P
A
L
M
V
A
G
T
L
V
G
A
A
G
T
L
L
T
V
L
M
A
R
A
M
N
R
S
V
W
S
V
L
V
G
G
-------------
K
G
S
L
K
P
I
D
V
E
---
D
A
A
V
M
L
-
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
R
-
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
R
L
36
HHSearch
67.70
57%
-97
- C6 -
1PNO
1
PNTB_RHORT
A:
[3-180]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
E
G
R
H
M
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
34
HHSearch
67.53
58%
-99
- C6 -
2FSV
1
C:
[30-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
W
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
2
PsiBlast_PDB
67.16
62%
-102
- C6 -
4J16
3
?
C:
[12-185]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
I
D
V
E
---
D
A
A
V
M
L
-
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
R
-
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
R
L
12
PsiBlast_PDB
66.87
59%
-102
- C6 -
2FSV
1
C:
[30-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
W
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
37
HHSearch
66.84
61%
-102
- C6 -
4J1T
1
?
C:
[9-185]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
L
K
P
I
D
V
E
---
D
A
A
V
M
L
-
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
R
-
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
R
L
3
PsiBlast_PDB
66.78
62%
-104
- C6 -
4J1T
1
?
C:
[12-185]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
I
D
V
E
---
D
A
A
V
M
L
-
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
R
-
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
R
L
21
PsiBlast_CBE
66.41
62%
-98
- C6 -
4J1T
2
?
F:
[12-185]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
I
D
V
E
---
D
A
A
V
M
L
-
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
R
-
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
R
L
16
PsiBlast_PDB
66.34
59%
-98
- C6 -
1PNO
1
PNTB_RHORT
A:
[1-175]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
H
I
E
G
R
H
M
-
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
23
PsiBlast_CBE
66.23
59%
-104
- C6 -
1PNO
2
B:
[4-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
G
R
H
M
-
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
22
PsiBlast_CBE
66.03
59%
-103
- C6 -
1PNQ
2
B:
[4-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
G
R
H
M
-
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
17
PsiBlast_PDB
65.72
59%
-94
- C6 -
1PNQ
1
PNTB_RHORT
A:
[1-175]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
H
I
E
G
R
H
M
-
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
9
PsiBlast_PDB
65.03
59%
-102
- C6 -
1U2G
2
C:
[30-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
18
PsiBlast_PDB
64.64
60%
-103
- C6 -
1XLT
2
PNTB_RHORT
C:
[1-169]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
M
-
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
7
PsiBlast_PDB
64.55
59%
-107
- C6 -
1U28
1
C:
[30-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
14
PsiBlast_PDB
64.48
61%
-102
- C6 -
2OO5
2
C:
[2-169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
15
PsiBlast_PDB
64.47
61%
-102
- C6 -
2OOR
1
C:
[2-169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
6
PsiBlast_PDB
64.22
59%
-100
- C6 -
1NM5
1
C:
[30-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
8
PsiBlast_PDB
64.17
59%
-99
- C6 -
1U2D
2
C:
[30-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
10
PsiBlast_PDB
63.86
59%
-102
- C6 -
2FR8
1
C:
[30-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
13
PsiBlast_PDB
63.02
61%
-105
- C6 -
1PTJ
1
C:
[2-169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
33
HHSearch
62.87
45%
-88
- C6 -
1DJL
3
NNTM_HUMAN
A:
[23-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
---
N
A
I
D
M
I
-
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
E
-
11
PsiBlast_PDB
62.79
59%
-97
- C6 -
2FRD
2
C:
[30-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
54
Fugue
62.11
46%
-91
* C6 *
1D4O
1
A:
[5-181]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
T
E
I
N
L
D
---
N
A
I
D
M
I
-
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
S
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
E
S
35
HHSearch
62.07
47%
-91
- C6 -
1D4O
1
A:
[5-180]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
T
E
I
N
L
D
---
N
A
I
D
M
I
-
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
S
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
E
-
5
PsiBlast_PDB
62.04
59%
-102
- C6 -
1HZZ
1
C:
[30-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
30
PsiBlast_CBE
61.83
47%
-96
- C6 -
1DJL
3
B:
[23-202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
INL
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
31
PsiBlast_CBE
61.47
51%
-95
- C6 -
1D4O
1
A:
[13-179]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
S
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
26
PsiBlast_CBE
61.40
47%
-98
- C6 -
1U31
3
B:
[23-202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
INL
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
27
PsiBlast_CBE
61.06
47%
-92
- C6 -
1U31
3
NNTM_HUMAN
A:
[23-202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
28
PsiBlast_CBE
61.05
47%
-97
- C6 -
1PT9
3
B:
[23-202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
INL
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
20
PsiBlast_PDB
60.31
47%
-91
- C6 -
1DJL
3
NNTM_HUMAN
A:
[23-202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
29
PsiBlast_CBE
59.65
47%
-92
- C6 -
1PT9
3
NNTM_HUMAN
A:
[23-202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
19
PsiBlast_PDB
59.09
55%
-95
- C6 -
2BRU
2
C:
[20-186]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
---
E
T
A
E
L
L
-
K
N
S
H
S
V
I
I
T
P
G
Y
G
M
A
V
A
Q
A
Q
Y
P
V
A
E
I
T
E
K
L
R
A
R
G
I
N
V
R
F
G
I
H
P
V
A
G
R
L
P
G
H
M
N
V
L
L
A
E
A
K
V
P
Y
D
I
V
L
E
M
D
E
I
N
D
D
F
A
D
T
D
T
V
L
V
I
G
A
N
D
T
V
N
P
A
A
Q
D
D
P
K
S
P
I
A
G
M
P
V
L
E
V
W
K
A
Q
N
V
I
V
F
K
R
S
M
N
T
G
Y
A
G
V
Q
N
P
L
F
F
K
E
N
T
H
M
L
F
G
D
A
K
A
S
V
D
A
I
---
L
K
A
L
38
HHSearch
57.37
53%
-88
- C6 -
2BRU
2
C:
[20-186]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
---
E
T
A
E
L
L
-
K
N
S
H
S
V
I
I
T
P
G
Y
G
M
A
V
A
Q
A
Q
Y
P
V
A
E
I
T
E
K
L
R
A
R
G
I
N
V
R
F
G
I
H
P
V
A
G
R
L
P
G
H
M
N
V
L
L
A
E
A
K
V
P
Y
D
I
V
L
E
M
D
E
I
N
D
D
F
A
D
T
D
T
V
L
V
I
G
A
N
D
T
V
N
P
A
A
Q
D
D
P
K
S
P
I
A
G
M
P
V
L
E
V
W
K
A
Q
N
V
I
V
F
K
R
S
M
N
T
G
Y
A
G
V
Q
N
P
L
F
F
K
E
N
T
H
M
L
F
G
D
A
K
A
S
V
D
A
I
L
K
A
L
---
4
PsiBlast_PDB
56.20
59%
-89
- C6 -
1E3T
1
A:
[29-198]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
-------
53
Fugue
56.09
59%
-83
- C6 -
1E3T
1
A:
[29-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
K
A
G
S
A
E
---
D
A
A
F
I
M
-
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--