@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0162c: (2016-04-20 )
MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGEVLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAVGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRGGRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAKALGAHEIYTPQQATAGGVKAAVVVEAVGHPAALHTAIGLTAPGGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL
Atome Classification :
(58 SA)
.........10........20........30-..-......40........50........60.....-...70.-...-....80........90........100.......110.......120.......130....-...140....--...150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250......-----------.---------260-------..---------.......270....-...280..-...-..290........300.......310.......320.......330.......340.......350.......360.......370.......380.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPAV
Q
P
W
L
YSNM
P
A
I
R
G
A
V
L
D
QIGVPRPYWR-SK-P
I
S
V
V
E
L
HLDPPDRG
E
V
L
V
R
I
EAAGVCHSDLSV-VDGTRV-R
P
V
-
P
I
L
LGH
E
A
A
G
I
V
E
Q
VGDGVD
G
V
A
VG
Q
R
V
V
L
V
FLPRCGQCAACATDGRTPCEPGSAANKA
G
T
-
L
LGG
G
I
R
LSR--GGRP
V
Y
H
HLGVSG
F
A
T
H
V
V
V
NR
A
S
VVPVPHEV
P
P
T
V
A
A
L
L
G
C
A
V
LTGG
G
A
V
L
NVGDPQPG
Q
S
V
A
V
V
GLG
G
V
G
M
A
A
V
L
T
A
L
TYT
D
V
R
V
V
A
V
D
Q
L
P
E
K
L
S
A
A
K
ALGAHEIYTPQ-----------Q---------A---------TA---------GG
V
K
A
A
V
V
V
EAVGH-
P
A
A
L
H
T
A
I
-
G
L
T-APG-G
R
T
I
T
V
GLPPP
D
V
R
I
S
LS
P
L
D
F
V
T
E
G
R
S
L
I
G
S
Y
L
GSAVPS
H
D
I
P
R
F
V
S
L
W
QSGRL
P
V
E
S
L
V
T
S
T
I
RL
D
D
I
N
E
A
M
D
H
L
A
D
G
I
A
V
R
Q
L
I
S
FTGDL
113
HHSearch
90.36
31%
-116
- C1 -
4RQT
6
ADH1_ARATH
A:
[2-374]
----------
Q
I
I
R
C
K
A
A
V
A
W
E
A
G
---------
K
-
P
L
V
I
E
E
V
E
V
A
P
P
Q
K
H
E
V
R
I
K
I
L
F
T
S
L
C
H
T
D
V
Y
F
-
W
E
A
K
G
Q
T
P
L
F
-
P
R
I
F
G
H
E
A
G
G
I
V
E
S
V
G
E
G
V
T
D
L
Q
P
G
D
H
V
L
P
I
F
T
G
E
C
G
E
C
R
H
C
H
S
E
E
S
N
M
C
D
L
L
R
I
N
T
E
R
G
G
M
I
H
D
G
E
S
R
F
S
I
--
N
G
K
P
I
Y
H
F
L
G
T
S
T
F
S
E
Y
T
V
V
H
S
G
Q
V
A
K
I
N
P
D
A
P
L
D
K
V
C
I
V
S
C
G
L
S
T
G
L
G
A
T
L
N
V
A
K
P
K
K
G
Q
S
V
A
I
F
G
L
G
A
V
G
L
G
A
A
E
G
A
R
I
A
G
A
S
R
I
I
G
V
D
F
N
S
K
R
F
D
Q
A
K
E
F
G
V
T
E
C
V
N
P
K
-----------
D
---------
H
DKP
I
Q
Q
V
I
A
E
M
---------
T
D
G
G
V
D
R
S
V
E
C
T
G
S
-
V
Q
A
M
I
Q
A
F
-
E
C
V
-
H
D
G
W
G
V
A
V
L
V
G
V
P
S
K
D
D
A
F
K
T
H
-
P
M
N
F
L
N
E
R
T
L
K
G
T
F
F
G
N
Y
K
P
K
T
D
I
P
G
V
V
E
K
Y
M
N
K
E
L
E
L
E
K
F
I
T
H
T
V
P
F
S
E
I
N
K
A
F
D
Y
M
L
K
G
E
S
I
R
C
I
I
T
M
G
---
22
PsiBlast_CBE
89.15
33%
-111
- C1 -
1HT0
4
ADH1G_HUMAN
B:
[15-374]
-----------------------------
W
E
L
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
A
G
I
C
R
S
D
E
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
S
G
K
P
I
H
H
F
V
G
V
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKPIQEVLK
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
Q
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
E
S
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
N
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
K
S
I
R
T
V
L
T
F
----
6
PsiBlast_PDB
88.71
33%
-113
- C1 -
1DEH
4
ADH1B_HUMAN
A:
[15-374]
-----------------------------
W
E
V
K
K
-
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKP
I
Q
E
V
L
K
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
----
73
PsiBlast_CBE
88.65
31%
-113
- C1 -
1LDE
4
ADH1E_HORSE
C:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
101
Fugue
88.19
33%
-114
- C1 -
3HUD
3
ADH1B_HUMAN
A:
[1-374]
------------
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
--
V
-
K
K
-
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
-
V
S
G
N
-
L
-
V
T
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKP
I
Q
E
V
L
K
E
---------
M
---------
T
D
---------
G
G
V
D
--
F
S
F
E
V
I
G
R
-
L
D
T
M
M
A
S
L
-
L
C
C
-
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
----
27
PsiBlast_CBE
88.15
33%
-112
- C1 -
1HSZ
4
ADH1B_HUMAN
B:
[15-374]
-----------------------------
W
E
V
K
K
-
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKPIQEVLK
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
----
100
PsiBlast_CBE
87.83
31%
-115
- C1 -
1D1T
22
ADH7_HUMAN
C:
[15-373]
-----------------------------
W
E
-
Q
K
Q
P
F
S
I
E
E
I
E
V
A
P
P
K
T
K
E
V
R
I
K
I
L
A
T
G
I
C
R
T
D
D
H
V
-
I
K
G
T
M
V
-
S
K
F
-
P
V
I
V
G
H
E
A
T
G
I
V
E
S
I
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
L
P
Q
C
R
E
C
N
A
C
R
N
P
D
G
N
L
C
I
R
S
D
I
T
G
R
-
G
V
-
L
A
D
G
T
T
R
F
T
C
--
K
G
K
P
V
H
H
F
L
N
T
S
T
F
T
E
Y
T
V
V
D
E
S
S
V
A
K
I
D
D
A
A
P
P
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
A
A
V
K
T
G
K
V
K
P
G
S
T
C
V
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
S
A
G
A
S
R
I
I
G
I
D
L
N
K
D
K
F
E
K
A
M
A
V
G
A
T
E
C
I
S
P
K
-----------
D
---------
S
---------
T
K
PISEVLSEM
T
G
N
N
V
G
Y
T
F
E
V
I
G
H
-
L
E
T
M
I
D
A
L
-
A
S
C
-
H
M
N
Y
G
T
S
V
V
V
G
V
P
P
S
A
K
M
L
T
Y
D
P
M
L
L
F
T
-
G
R
T
W
K
G
C
V
F
G
G
L
K
S
R
D
D
V
P
K
L
V
T
E
F
L
A
K
K
F
D
L
D
Q
L
I
T
H
V
L
P
F
K
K
I
S
E
G
F
E
L
L
N
S
G
Q
S
I
R
T
V
L
T
F
----
78
PsiBlast_CBE
87.57
31%
-113
- C1 -
1HF3
4
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
99
PsiBlast_CBE
87.45
31%
-115
- C1 -
1D1T
25
ADH7_HUMAN
D:
[15-373]
-----------------------------
W
E
-
Q
K
Q
P
F
S
I
E
E
I
E
V
A
P
P
K
T
K
E
V
R
I
K
I
L
A
T
G
I
C
R
T
D
D
H
V
-
I
K
G
T
M
V
-
S
K
F
-
P
V
I
V
G
H
E
A
T
G
I
V
E
S
I
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
L
P
Q
C
R
E
C
N
A
C
R
N
P
D
G
N
L
C
I
R
S
D
I
T
G
R
-
G
V
-
L
A
D
G
T
T
R
F
T
C
--
K
G
K
P
V
H
H
F
L
N
T
S
T
F
T
E
Y
T
V
V
D
E
S
S
V
A
K
I
D
D
A
A
P
P
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
A
A
V
K
T
G
K
V
K
P
G
S
T
C
V
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
S
A
G
A
S
R
I
I
G
I
D
L
N
K
D
K
F
E
K
A
M
A
V
G
A
T
E
C
I
S
P
K
-----------
D
---------
S
---------
T
K
PISEVLSEM
T
G
N
N
V
G
Y
T
F
E
V
I
G
H
-
L
E
T
M
I
D
A
L
-
A
S
C
-
H
M
N
Y
G
T
S
V
V
V
G
V
P
P
S
A
K
M
L
T
Y
D
P
M
L
L
F
T
-
G
R
T
W
K
G
C
V
F
G
G
L
K
S
R
D
D
V
P
K
L
V
T
E
F
L
A
K
K
F
D
L
D
Q
L
I
T
H
V
L
P
F
K
K
I
S
E
G
F
E
L
L
N
S
G
Q
S
I
R
T
V
L
T
F
----
11
PsiBlast_PDB
87.44
33%
-115
- C1 -
1U3T
5
ADH1A_HUMAN
A:
[15-374]
-----------------------------
W
E
L
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
V
-
V
S
G
T
M
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
P
Q
G
T
-
L
Q
D
G
T
S
R
F
T
C
--
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKP
I
Q
E
V
L
K
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
----
84
PsiBlast_CBE
87.41
31%
-114
- C1 -
1BTO
5
ADH1E_HORSE
C:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
8
PsiBlast_PDB
87.24
33%
-112
- C1 -
1U3U
6
ADH1B_HUMAN
A:
[15-374]
-----------------------------
W
E
V
K
K
-
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKP
I
Q
E
V
L
K
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
----
13
PsiBlast_PDB
87.12
33%
-112
- C1 -
1HTB
4
ADH1B_HUMAN
A:
[15-374]
-----------------------------
W
E
V
K
K
-
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKP
I
Q
E
V
L
K
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
C
T
V
L
T
F
----
1
PsiBlast_PDB
87.12
33%
-113
- C1 -
1HT0
4
ADH1G_HUMAN
A:
[15-374]
-----------------------------
W
E
L
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
A
G
I
C
R
S
D
E
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
S
G
K
P
I
H
H
F
V
G
V
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKP
I
Q
E
V
L
K
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
Q
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
E
S
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
N
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
K
S
I
R
T
V
L
T
F
----
85
PsiBlast_CBE
87.06
31%
-112
- C1 -
1BTO
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
112
HHSearch
86.92
32%
-111
- C1 -
2JHF
4
ADH1E_HORSE
A:
[3-373]
--------
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
---------
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
-----------
D
YKKP
I
Q
E
V
L
T
---------
E
M
---------
S
N
G
G
V
D
F
S
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
Q
E
A
Y
-
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
-
M
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
-----
69
PsiBlast_CBE
86.86
31%
-112
- C1 -
1LDY
4
ADH1E_HORSE
C:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
10
PsiBlast_PDB
86.69
33%
-110
- C1 -
1HSO
5
ADH1A_HUMAN
A:
[15-374]
-----------------------------
W
E
L
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
V
-
V
S
G
T
M
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
P
Q
G
T
-
L
Q
D
G
T
S
R
F
T
C
--
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKP
I
Q
E
V
L
K
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
----
20
PsiBlast_PDB
86.68
31%
-113
- C1 -
1HLD
5
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
95
PsiBlast_CBE
86.63
31%
-112
* C1 *
1QV7
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
Q
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
R
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
51
PsiBlast_CBE
86.06
31%
-112
- C1 -
2OXI
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
19
PsiBlast_PDB
85.82
31%
-112
- C1 -
2OXI
5
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
53
PsiBlast_CBE
85.71
31%
-111
- C1 -
2JHG
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
34
PsiBlast_CBE
85.71
31%
-112
- C1 -
4NFH
7
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
26
PsiBlast_CBE
85.62
33%
-110
- C1 -
1U3U
6
ADH1B_HUMAN
B:
[15-374]
-----------------------------
W
E
V
K
K
-
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKPIQEVLK
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
----
16
PsiBlast_PDB
85.57
31%
-114
- C1 -
5CDU
6
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
V
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
54
PsiBlast_CBE
85.47
31%
-112
- C1 -
2JHG
4
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
44
PsiBlast_CBE
85.45
31%
-113
- C1 -
4DXH
8
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
93
PsiBlast_CBE
85.30
31%
-112
- C1 -
3OQ6
6
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
C
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
97
PsiBlast_CBE
85.24
31%
-112
- C1 -
1QV6
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
Q
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
R
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
14
PsiBlast_PDB
85.23
31%
-113
- C1 -
4NFH
9
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
15
PsiBlast_PDB
85.11
31%
-113
- C1 -
5CDT
8
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
V
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
35
PsiBlast_CBE
85.02
31%
-111
- C1 -
5CDU
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
V
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
21
PsiBlast_CBE
85.02
33%
-109
- C1 -
1U3W
6
ADH1G_HUMAN
B:
[15-374]
-----------------------------
W
E
L
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
A
G
I
C
R
S
D
E
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
S
G
K
P
I
H
H
F
V
G
V
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKPIQEVLK
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
Q
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
E
S
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
N
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
K
S
I
R
T
V
L
T
F
----
46
PsiBlast_CBE
85.01
31%
-113
- C1 -
4DWV
9
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
94
PsiBlast_CBE
84.81
31%
-114
- C1 -
3OQ6
8
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
C
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
77
PsiBlast_CBE
84.81
31%
-111
- C1 -
1HF3
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
18
PsiBlast_PDB
84.77
31%
-111
- C1 -
2OHX
5
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
36
PsiBlast_CBE
84.68
31%
-110
- C1 -
5CDT
6
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
V
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
62
PsiBlast_CBE
84.46
31%
-112
- C1 -
1N92
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
63
PsiBlast_CBE
84.43
31%
-111
- C1 -
1N92
5
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
57
PsiBlast_CBE
84.12
31%
-113
- C1 -
1YE3
3
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
55
PsiBlast_CBE
84.06
31%
-110
- C1 -
2JHF
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
52
PsiBlast_CBE
84.02
31%
-110
- C1 -
2OHX
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
2
PsiBlast_PDB
83.96
33%
-109
- C1 -
1U3W
6
ADH1G_HUMAN
A:
[15-374]
-----------------------------
W
E
L
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
A
G
I
C
R
S
D
E
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
S
G
K
P
I
H
H
F
V
G
V
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKP
I
Q
E
V
L
K
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
Q
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
E
S
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
N
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
K
S
I
R
T
V
L
T
F
----
3
PsiBlast_PDB
83.88
34%
-111
- C1 -
1HDY
4
ADH1B_HUMAN
A:
[15-374]
-----------------------------
W
E
V
K
K
-
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
H
T
D
D
H
V
-
V
S
G
N
L
V
-
T
P
L
-
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
P
R
G
T
-
L
Q
D
G
T
R
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
DYKKP
I
Q
E
V
L
K
E
---------
M
---------
T
D
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
-
C
C
H
-
E
A
C
-
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
----
96
PsiBlast_CBE
83.82
31%
-110
- C1 -
1QV7
5
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
Q
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
R
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
43
PsiBlast_CBE
83.78
31%
-111
- C1 -
4DXH
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
91
PsiBlast_CBE
83.36
31%
-113
- C1 -
1ADB
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
56
PsiBlast_CBE
83.34
31%
-109
- C1 -
2JHF
4
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
45
PsiBlast_CBE
83.31
31%
-111
- C1 -
4DWV
7
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
98
PsiBlast_CBE
83.00
31%
-111
- C1 -
1QV6
6
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
Q
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
R
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
76
PsiBlast_CBE
82.39
31%
-110
- C1 -
1HLD
7
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
89
PsiBlast_CBE
80.52
31%
-113
- C1 -
1ADC
5
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
90
PsiBlast_CBE
79.90
31%
-113
- C1 -
1ADC
5
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
117
HHSearch
79.57
30%
-108
- C1 -
1CDO
3
ADH1_GADMC
A:
[3-373]
--------
V
G
K
V
I
K
C
K
A
A
V
A
W
E
A
N
---------
K
-
P
L
V
I
E
E
I
E
V
D
V
P
H
A
N
E
I
R
I
K
I
I
A
T
G
V
C
H
T
D
L
Y
H
L
F
E
G
K
H
K
-
D
G
F
-
P
V
V
L
G
H
E
G
A
G
I
V
E
S
V
G
P
G
V
T
E
F
Q
P
G
E
K
V
I
P
L
F
I
S
Q
C
G
E
C
R
F
C
Q
S
P
K
T
N
Q
C
V
K
G
W
A
N
E
S
P
D
--
V
M
-
S
P
K
E
T
R
F
TC
K
G
R
K
V
L
Q
F
L
G
T
S
T
F
S
Q
Y
T
V
V
N
Q
I
A
V
A
K
I
D
P
S
A
P
L
D
T
V
C
L
L
G
C
G
V
S
T
G
F
G
A
A
V
N
T
A
K
V
E
P
G
S
T
C
A
V
F
G
L
G
A
V
G
L
A
A
V
M
G
C
H
S
A
G
A
K
R
I
I
A
V
D
L
N
P
D
K
F
E
K
A
K
V
F
G
A
T
D
F
V
N
P
N
-----------
D
HSEP
I
S
Q
V
L
S
---------
K
M
---------
T
N
G
G
V
D
F
S
L
E
C
V
G
N
-
V
G
V
M
R
N
A
L
E
S
C
L
-
K
G
W
-
G
V
S
V
L
V
G
W
T
D
L
H
D
V
-
A
T
R
P
I
Q
-
L
I
A
G
R
T
W
K
G
S
M
F
G
G
F
K
G
K
D
G
V
P
K
M
V
K
A
Y
L
D
K
K
V
K
L
D
E
F
I
T
H
R
M
P
L
E
S
V
N
D
A
I
D
L
M
K
H
G
K
C
I
R
T
V
L
S
-----
39
PsiBlast_CBE
77.55
31%
-112
- C1 -
6ADH
4
ADH1E_HORSE
B:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKPIQEVLT
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----
17
PsiBlast_PDB
77.22
31%
-113
- C1 -
6ADH
4
ADH1E_HORSE
A:
[15-374]
----------------------------
W
E
E
-
K
K
-
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
-
V
S
G
T
L
V
-
T
P
L
-
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
P
R
G
T
-
M
Q
D
G
T
S
R
F
T
C
--
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
DYKKP
I
Q
E
V
L
T
E
---------
M
---------
S
N
---------
G
G
V
D
F
S
--
F
E
V
I
G
R
-
L
D
T
M
V
T
A
L
-
S
C
C
-
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
-
L
L
L
S
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
----