@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0167: (2016-04-20 )
MTTSTTLGGYVRDQLQTPLTLVGGFFRMCVLTGKALFRWPFQWREFILQCWFIMRVGFLPTIMVSIPLTVLLIFTLNILLAQFGAADISGSGAAIGAVTQLGPLTTVLVVAGAGSTAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVLASMLVATLLNGLVITVGLVGGFLFGVYLQNVSGGAYLATLTLITGLPEVVIATIKAATFGLIAGLVGCYRGLTVRGGSKGLGTAVNETVVLCVIALFAVNVILTTIGVRFGTGR
Atome Classification :
(20 SA)
-----------------------------------------------------.......-..10------.........20-----..------...-----....30...---------.....40----.......----.------50...------.....60-...--.----.-------...70..-----....-------..80...----.....90...-....--.100.----......110.......120.......130.....-------------.-------.140.......------150------........160.--.--......---170-.......----------------180---.....----------....190....--------.-----..200...---......210-------.........220......----------.230....------...240-----.....---------..250.......260...------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------MTTSTTL-
G
G
Y
-------
V
R
D
Q
LQ
T
P
L
T
------
L
V
------
G
G
F
-----
F
R
M
C
V
LTG
K
---------
A
L
FRW
P
F
----
Q
W
R
E
F
I
L
----
Q
------
C
W
F
I
M
------
R
VGFLP
T
-
I
M
V
--
S
----
I
-------
P
L
T
V
L
L
I
-----
F
T
L
N
-------
I
L
L
A
QFG----AADISGSGA
A
-
I
G
A
V
--TQLGP----
L
T
T
V
L
V
V
AGAGS
T
A
I
C
A
D
L
G
A
R
T
I
R
E
E
I
D
A
M
EVL-------------G-------I
D
P
I
H
R
L
V
V
P
R
------
V
L
-------
A
S
M
L
V
A
T
L
LN-G--L--
V
I
T
V
G
L
---
V
G
G
-
F
L
F
G
V
Y
L
----------------Q-----NVSG
G
----------
A
Y
L
A
T
L
T
L
ITG--------
L
-----
P
E
V
--
V
I
A
---
T
I
K
A
A
T
F
---------
G
L
I
A
G
L
V
G
C
YRG
L
T
VRGG----------SKGLG
T
A
V
------
N
E
T
V
V
L
-----
C
V
I
A
L
---------
F
A
V
N
V
I
L
T
T
I
G
V
RFGTGR------------------------------------------------
24
Fugue
96.08
23%
-148
* C5 *
4ZOX
-
SQT1_YEAST
A:
[53-431]
-------MSNNSL
T
Y
F
D
KHTDSVF
A
I
G
H
H
PNLP
L
V
C
T
G
GGDN
L
A
H
L
W
T
SHSQP
P
K
F
A
G
T
L
-
T
G
Y
-------
G
E
S
V
I
S
C
S
F
T
------
S
E
------
G
G
F
-----
L
V
T
A
D
M
S
G
K
---------
V
L
V
H
M
G
Q
KGGA
Q
W
K
L
A
S
Q
----
M
Q
EVEEI
V
W
L
K
T
------
H
P
T
I
A
R
T
-
F
A
F
--
G
----
A
-------
T
D
G
S
V
W
C
-----
Y
Q
I
N
EQDG
S
L
E
Q
L
M
S
G
F
V
----
H
Q
Q
D
C
S
M
G
E
F
-
I
N
----
T
D
K
G
E
----
N
T
L
E
L
V
T
C
S
L
D
S
T
I
V
A
W
N
C
F
T
G
Q
Q
L
F
K
I
T
Q
A
E
I
K
-------------
G
-------
L
E
------
A
P
W
------
I
S
-------
L
S
L
A
P
E
T
L
T
K
-
G
--
N
S
G
V
V
A
C
G
S
---
N
N
G
-
L
L
A
V
I
N
C
----------------
N
-----
N
--
G
G
----------
A
I
L
H
L
S
T
V
I
E
L
--------
K
-----
P
E
Q
DE
L
D
A
---
S
I
E
S
I
S
W
S
SKFS
L
M
A
I
G
L
V
C
G
E
I
L
L
Y
D
T
S
A
W
R
V
R
----------
H
K
F
V
L
E
D
S
------
V
T
K
L
M
F
-----
D
N
D
D
L
---------
F
A
S
C
I
N
G
K
V
Y
Q
F
N
A
R
T
G
Q
EK
F
V
C
V
GHNMGVL
D
F
I
L
L
H
PVANTG
T
E
Q
K
R
K
V
I
T
A
G
DEG
V
S
L
V
F
E
V
P
N
33
Fugue
87.61
19%
-148
- C3 -
3N28
6
SERB_VIBCH
A:
[3-325]
-----------------------------------------------------
L
D
A
L
T
T
L
-
P
I
K
-------
K
H
T
A
L
L
N
R
F
P
------
E
T
RFVTQL
A
K
K
-----
R
A
S
W
I
V
F
G
H
---------
Y
L
T
P
A
Q
F
----
E
D
M
D
F
F
T
N
R
F
N
A
------
I
L
D
M
W
------
K
V
G
R
Y
E
V
-
A
L
M
--
D
----
G
-------
E
L
T
S
E
H
E
-----
T
I
L
K
-------
A
L
E
L
D
Y
A
R
IQD
V
P
D
L
T
K
P
G
L
I
-
V
L
D
M
DS
T
A
I
Q
I
----
E
C
I
D
E
I
A
K
L
A
G
V
G
E
E
V
A
E
V
T
E
R
A
M
Q
G
E
L
D
F
E
Q
S
L
R
L
R
V
S
K
L
KDAPEQ
I
-------
L
S
Q
V
R
E
T
L
P
L
M
------
P
E
-------
L
P
E
L
V
A
T
L
H
A
F
G
--
W
--
K
V
A
I
A
S
---
G
G
F
-
T
Y
F
S
D
Y
L
----------------
K
-----
E
Q
L
S
L
----------
D
Y
A
Q
S
N
T
L
E
I
V
SGKLTGQV
L
-----
G
E
V
--
V
S
A
---
Q
T
K
A
D
I
L
---------
L
T
L
A
Q
Q
Y
D
V
E
I
H
N
T
V
A
V
G
D
G
AND
L
V
M
M
A
A
A
G
L
G
V
A
Y
------
H
A
K
P
K
V
E
A
K
AQ
T
A
V
R
F
---------
A
G
L
G
G
V
V
C
I
L
S
A
A
L
V
A
Q
Q
KLSWK-------------------------------------------
28
Fugue
82.00
19%
-157
- C6 -
1G19
1
RECA_MYCTU
A:
[1-269]
-----------------------------------------------------
M
T
Q
T
P
D
R
-
E
K
A
-------
L
E
L
A
V
A
Q
I
E
K
------
S
Y
------
G
K
G
-----
S
V
M
R
L
G
D
E
A
---------
R
Q
P
I
S
V
I
----
P
T
G
S
I
A
L
----
D
------
V
A
--
L
------
G
I
G
G
L
P
R
G
R
V
I
--
E
----
I
Y
G
P
ESSG
K
T
T
V
A
L
H
-----
A
V
A
N
-------
A
Q
A
A
G
G
V
----
A
A
F
I
D
A
E
H
A
L
D
P
D
Y
A
--
K
K
L
G
V
----
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
I
R
S
--
G
A
L
D
I
V
-------------
V
-------
I
D
S
V
A
A
L
V
P
R
A
------
E
L
E
GEHVGL
Q
A
R
L
M
S
Q
A
L
R
-
K
--
M
--
T
G
A
L
N
N
---
S
G
T
---
T
A
I
F
I
----------------
N
-----
Q
L
T
G
G
----------
K
A
L
K
F
Y
A
S
V
R
---------
M
-----
D
V
R
--
R
V
E
---
T
L
K
D
------------------------------------------
G
T
N
A
V
G
------
N
R
T
R
V
K
-----
V
V
K
N
K
---------
C
L
A
P
F
K
Q
A
E
F
D
I
L
Y
G
K
G
I
------------------------------------------------
32
Fugue
81.85
20%
-167
- C5 -
4BVA
3
CRYM_MOUSE
A:
[24-334]
-----------------------------------------------------
K
R
A
P
A
F
L
S
A
E
E
-------
V
Q
D
H
L
R
S
S
S
L
------
L
I
------
P
P
L
-----
E
A
A
L
A
N
F
S
K
GPDGG
V
M
Q
P
V
R
T
V
V
P
V
----
A
K
H
R
G
F
L
----
G
------
V
M
P
A
Y
S
AAED
A
L
T
T
K
L
V
T
-
F
Y
E
--
S
----
H
-------
Q
A
S
V
L
L
F
DPSNG
S
L
L
A
-------
V
M
D
G
N
V
I
----
T
A
K
R
T
A
A
V
S
A
-
I
A
T
K
--
L
L
K
P
P
----
G
S
D
V
L
C
I
L
G
A
G
---
V
Q
A
Y
S
H
Y
E
I
F
T
E
Q
F
S
F
K
E
V
R
-------------
M
W
N
RT
R
E
N
A
E
K
F
A
S
T
V
Q
G
D
------
V
R
-------
V
C
S
S
V
Q
E
A
V
T
-
G
AD
V
--
I
I
T
V
T
M
---
A
T
E
P
I
L
F
G
E
W
V
----------------
K
PG
A
H
I
N
A
V
G
A
SRPDWRELD
D
E
L
M
R
Q
A
V
L
Y
V
D
--------
S
-----
R
E
A
--
A
L
K
ES
G
D
V
L
L
S
G
A
---------
D
I
F
A
E
L
G
E
V
I
S
G
A
K
P
A
H
C
----------
E
K
---
T
T
V
------
F
K
S
L
G
M
-----
A
V
E
D
L
---------
V
A
A
K
L
V
Y
D
S
W
S
S
G
-----------------------------------------------------
27
Fugue
76.71
20%
-123
- C6 -
4BWZ
2
?
A:
[3-386]
G
A
E
H
L
L
E
I
F
Y
L
L
L
A
A
Q
V
C
A
F
I
F
K
R
L
NQP
V
V
I
G
E
V
L
A
G
V
L
V
GPALLGLVHEG
E
I
L
E
F
L
A
E
L
-
G
A
V
F
L
L
F
M
V
G
L
E
T
R
L
K
D
I
L
A
------
V
G
------
K
E
A
-----
F
L
V
A
V
L
G
V
A
---------
L
P
F
L
G
G
Y
----
L
Y
G
L
E
I
------------
G
F
E
T
L
------
P
A
L
F
L
G
T
-
A
L
V
AT
S
----
V
-------
G
I
T
A
R
V
L
-----
Q
E
L
G
-------
V
L
--
S
R
P
----
Y
S
R
I
I
L
G
A
A
V
-
I
D
D
V
--
L
G
L
I
V
----
L
A
C
V
N
G
V
A
E
T
G
Q
V
E
V
G
A
I
T
R
L
I
V
L
S
V
V
F
V
G
L
A
V
F
-------------
L
-------
S
T
L
I
A
R
L
P
L
E
R
LPVGS
P
L
G
-------
F
A
L
A
L
G
V
G
M
A
-
A
--
L
--
A
A
S
I
G
L
A
P
I
V
G
A
-
F
L
G
G
M
L
L
S
EVREKYRL
E
E
P
I
F
A
I
E
-----
S
F
L
A
P
----------
I
F
F
A
M
V
G
V
R
L
E
--------
L
SALAS
P
V
V
--
L
V
A
---
G
T
V
V
T
V
I
---------
A
I
L
G
K
V
L
G
G
F
L
G
A
L
T
Q
G
V
----------
R
S
A
L
T
V
G
C
G
M
APRG
E
V
G
L
I
V
-----
A
A
L
G
L
K
A
GAVN
E
E
E
Y
A
I
V
L
F
M
V
V
F
T
T
L
F
A
P
F
A
L
K
P
L
I
A
W
T
E
R
E
R
A
A
K
E--------------------------------
29
Fugue
67.36
16%
-89
- C6 -
2BHW
20
CB22_PEA
A:
[10-232]
-----------------------------------------------------
A
S
S
G
S
P
W
-
Y
G
P
-------
D
R
V
K
Y
L
G
P
F
S
GESPSY
L
T
------
G
E
F
PGDYG
W
D
T
A
G
L
S
A
D
---------
P
E
T
F
S
K
N
----
R
E
L
E
V
I
H
----
S
------
R
W
A
M
L
------
G
A
L
G
S
V
F
-
P
E
L
--
L
S
R
N
G
V
-------
K
F
G
E
A
V
W
-----
F
K
A
G
-------
S
Q
I
F
S
E
G
----
G
L
D
Y
L
G
N
P
S
L
-
V
H
A
Q
--
S
I
L
A
I
----
W
A
T
Q
V
I
L
M
G
A
V
E
G
Y
R
I
A
G
G
P
L
G
E
V
V
D
P
L
Y
P
G
G
S
F
----------------------
D
P
L
G
L
A
D
D
P
E
------
A
F
-------
A
E
L
K
V
K
E
L
K
N
-
G
--
R
--
L
A
M
F
S
M
---
F
G
F
-
F
V
Q
A
I
V
T
----------------
G
-----
K
------------------------
G
--------
P
-----
L
E
N
--
L
A
D
---
H
L
A
D
P
V
N
---------
N
N
A
W
S
Y
A
T
-----------------------------------------------------------------------
N
F
V
P
G
K
------------------------------------------------
8
PsiBlast_PDB
50.65
35%
-26
- C4 -
1BW9
3
DHPH_RHOSO
A:
[136-190]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
G
R
S
L
----------------
E
-----
R
--
G
G
----------
A
G
S
S
A
F
T
T
A
V
G
--------
V
-----
F
E
A
--
M
K
A
---
T
V
A
H
R
G
L
---------
G
S
L
D
G
L
T
V
L
V
Q
G
L
G
A
V
G
G
----------
S
--------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.49
35%
-31
- C4 -
1C1X
3
DHPH_RHOSO
B:
[135-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
G
R
S
L
----------------
E
-----
R
--
G
G
----------
A
G
S
S
A
F
T
T
A
V
G
--------
V
-----
F
E
A
--
M
K
A
---
T
V
A
H
R
G
L
---------
G
S
L
D
G
L
T
V
L
V
Q
G
L
G
A
V
G
G
----------
S
--------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
50.10
35%
-24
- C4 -
1C1D
2
DHPH_RHOSO
B:
[135-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
G
R
S
L
----------------
E
-----
R
--
G
G
----------
A
G
S
S
A
F
T
T
A
V
G
--------
V
-----
F
E
A
--
M
K
A
---
T
V
A
H
R
G
L
---------
G
S
L
D
G
L
T
V
L
V
Q
G
L
G
A
V
G
G
----------
S
--------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
49.74
35%
-33
- C4 -
1BXG
1
DHPH_RHOSO
A:
[136-190]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
G
R
S
L
----------------
E
-----
R
--
G
G
----------
A
G
S
S
A
F
T
T
A
V
G
--------
V
-----
F
E
A
--
M
K
A
---
T
V
A
H
R
G
L
---------
G
S
L
D
G
L
T
V
L
V
Q
G
L
G
A
V
G
G
----------
S
--------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.39
46%
17
- C4 -
3FUV
-
RSMA_THET8
A:
[48-86]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
--
F
E
V
G
P
GLG
A
L
T
R
A
L
L
E
A
G
A
E
V
T
A
I
E
K
D
L
R
L
R
P
V
L
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
47.62
29%
-87
- C4 -
3PC4
2
?
A:
[224-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
-
R
K
I
K
E
Q
V
P
S
C
Q
I
V
-------------
G
-------
V
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
47.53
29%
-83
- C4 -
3PC2
2
?
A:
[224-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
-
R
K
I
K
E
Q
V
P
S
C
Q
I
V
-------------
G
-------
V
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.26
46%
15
- C4 -
3FUX
1
RSMA_THET8
A:
[48-86]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
--
F
E
V
G
P
GLG
A
L
T
R
A
L
L
E
A
G
A
E
V
T
A
I
E
K
D
L
R
L
R
P
V
L
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
46.98
46%
37
- C4 -
3FUT
-
RSMA_THET8
A:
[48-86]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
--
F
E
V
G
P
GLG
A
L
T
R
A
L
L
E
A
G
A
E
V
T
A
I
E
K
D
L
R
L
R
P
V
L
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
46.70
36%
-66
* C7 *
4DIN
-
KAP1_HUMAN
B:
[173-219]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
F
--
Y
--
V
V
D
Q
G
E
---
V
D
V
-
Y
V
N
G
E
W
V
----------------
T
-----
N
I
S
E
G
----------
G
S
F
G
E
L
A
L
I
Y
G
--------
T
-----
P
R
A
----
A
---
T
V
K
A
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
46.41
46%
16
* C4 *
3FUU
1
RSMA_THET8
A:
[48-86]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
--
F
E
V
G
P
GLG
A
L
T
R
A
L
L
E
A
G
A
E
V
T
A
I
E
K
D
L
R
L
R
P
V
L
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
46.22
46%
17
- C4 -
3FUW
1
RSMA_THET8
A:
[48-86]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
--
F
E
V
G
P
GLG
A
L
T
R
A
L
L
E
A
G
A
E
V
T
A
I
E
K
D
L
R
L
R
P
V
L
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.04
29%
-84
- C4 -
3PC3
2
?
A:
[224-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
-
R
K
I
K
E
Q
V
P
S
C
Q
I
V
-------------
G
-------
V
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
39.28
30%
97
- C4 -
1Q74
1
MSHB_MYCTU
A:
[62-98]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
G
G
Y
R
I
G
E
L
T
A
A
L
R
A
L
-------------
G
-------
V
S
A
P
I
Y
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------