@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0169: (2016-04-20 )
MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKTQLTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDPRYIHLIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVTTEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTVLDDLNSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTINAQQAELDSALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYSPELFCTIRNFYDADPLAKAASGGGNGYSLRTNSEILSGIGISLLSPLALATNGAAIGIGLVAGLIAPPLAVAANLAGALPGIVGGAPNPYTYPENLPRVNARGGPGGAPGCWQPITRDLWPAPYLVMDTGASLAPYNHMEVGSPYAVEYVWGRQVGDNTINP
Atome Classification :
(20 SA)
----.....--------....10.---------.......20........30........40........50........60.-.......70........80........90........100.......--110.......120.......130.......140.......150.......160..-.....170.....--...180.......190.......200.......210..----.....220.......230..--.....240.......----------250.......260.......270.......280.....-------..290..-------.....--------------300...--....310......----.320.......330.......340.......350--........360.......370....-...380..-----.....390..-....-----.400.......----410.......420.......430......-.440.......450..--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MTTPG--------KLNKARV---------PPYKTA
G
L
G
L
V
L
V
F
A
L
V
V
A
L
V
Y
L
Q
FRGEFTPK
T
Q
L
T
M
L
SARA
G
L
V
MDPGS-
K
V
T
YNGVEIGR
V
D
T
I
S
E
V
TRDG
E
S
A
A
K
F
I
L
DVDP
R
Y
I
H
L
I
PANVNA
D
--
I
K
A
T
T
V
FG
G
K
Y
V
S
L
TTPKNPTKRRI
T
P
K
D
V
I
D
V
R
S
V
T
T
E
I
N
T
L
F
Q
T
L
T
S
I
A
EKVD-
P
V
K
L
N
L
T
-
L
S
A
A
A
--
E
A
L
T
G
L
G
D
K
F
G
E
S
IV
N
A
N
T
V
L
D
D
L
N
S
RMPQ
S
R
H
D
I
Q
Q
L
----
A
A
L
G
D
V
Y
ADA
A
P
D
L
F
D
F
L
DS--SVT
T
A
R
TI
N
A
Q
Q
A
E
L
----------
D
S
A
L
L
A
AAGFGN
T
T
A
D
V
FDRG
G
P
Y
L
Q
R
G
V
A
D
LVP
T
A
T
L
-------LDTYSP
E
-------
L
F
C
T
I
--------------
R
N
FYDA--
D
P
L
A
K
AASGGGN
G
----
Y
S
LRT
N
S
E
I
L
S
G
I
G
I
S
L
L
S
P
L
A
LATNGA
A
I
G
I
G
---
L
V
A
G
LIA
P
P
L
A
V
A
A
N
L
A
G
AL
P
G
IVG-GAPNPYTY-----PENLPRVNAR-GGPG-----GAPGCWQ
P
I
T
R
----DLWPA
P
Y
L
V
MDTGASLAPYNHMEVGS
P
Y
A
-
V
E
Y
V
WGRQVGDNTINP--
29
Fugue
87.91
21%
-48
- C4 -
4X90
12
PAG15_HUMAN
A:
[5-380]
H
P
P
V
V
L
V
P
G
DLG
N
Q
L
E
A
K
L
D
K
P
T
V
VHYLCSKKT
E
S
Y
F
T
I
W
L
N
L
E
L
L
L
P
V
I
I
D
C
W
I
D
N
I
R
L
V
Y
N
K
T
S
R
A
T
Q
F
P
--------
D
G
V
-
D
V
R
V
P
G
--
F
G
K
T
F
S
L
E
F
L
D
P
S
K
S
S
V
G
S
--------
Y
F
H
T
M
V
E
S
L
V
G
W
G
Y
T
R
G
E
D
V
R
G
A
P
Y
--------------------
D
W
R
R
A
P
N
E
N
G
P
Y
F
L
A
L
R
E
M
I
E
E
M
Y
-
Q
L
Y
G
G
P
V
-
V
L
V
A
H
--------------
S
M
G
N
M
Y
T
L
Y
F
L
Q
R
Q
P
Q
A
W
K
D
K
Y
I
R
A
F
----
V
S
L
G
A
P
W
G
G
V
A
------------------------------------
K
T
L
R
V
L
A
S
G
D
N
N
R
I
P
V
I
----
G
P
L
K
I
R
E
Q
Q
R
S
A
V
S
T
S
W
-------
L
L
P
Y
N
Y
T
-------
W
--------------------------
S
P
E
K
V
F
V
Q
T
P
T
I
N
----
Y
T
L
R
D
Y
R
K
F
F
Q
D
I
G
F
E
D
G
W
L
M
R
Q
D
T
E
G
---------
L
V
E
A
T
M
P
P
G
V
Q
--------
L
H
C
L
Y
G
T
G
V
P
T
P
D
S
F
Y
Y
ESF
P
D
R
D
P
K
I
C
F
G
-
D
G
D
G
TVNLK
S
A
L
Q
C
Q
A
W
Q
S
R
----
Q
E
H
Q
V
L
L
Q
E
L
P
G
S
E
------
H
I
E
M
L
A
N
A
T
-
T
L
A
Y
L
K
R
V
L
L
----
G
P
--
26
Fugue
86.09
18%
-37
- C4 -
3ZPJ
-
?
A:
[1-356]
----
M
T
T
L
E
--------
E
I
N
L
L
V
E
---------
R
G
Y
Y
E
E
A
L
A
K
V
Y
E
I
E
--------------
D
P
I
E
Q
V
Q
V
L
T
K
I
V
V
T
I
Y
Q
H
D
-----------
G
P
M
E
W
I
P
S
I
M
E
D
A
M
Y
I
A
K
K
L
R
D
------------
P
A
N
K
--
A
V
A
Y
S
I
I
A
S
T
L
A
I
M
E
Y
--------------------
E
E
D
A
M
D
F
F
N
R
A
I
D
E
A
N
E
I
E
S
P
I
E
K
G
M
V
-
L
S
T
L
A
--
Y
H
L
A
I
A
G
-
Y
P
D
N
A
L
E
I
F
N
I
A
F
D
T
I
I
G
A
E
T
S
Y
T
H
K
V
D
G
I
----
L
R
I
G
D
L
L
E
K
A
G
D
T
L
-----------------------------------
P
S
N
E
A
M
D
F
Y
K
M
A
F
D
I
F
D
K
--
L
H
V
N
Q
R
A
A
I
V
E
K
K
I
E
L
-------
A
K
T
--------------------------------
V
Y
D
V
GL
P
Q
I
R
A
A
L
L
K
G
K
N
H
----
Y
A
L
A
I
I
K
K
K
Y
S
G
-
V
M
R
L
I
G
E
L
E
V
A
L
W
M
K
R
V
N
-------------
N
M
E
Y
L
D
V
V
D
K
A
F
E
-
C
C
E
-
S
P
R
F
T
D
V
N
-----
V
Q
H
I
A
R
L
L
T
E
L
G
N
L
R
-----
R
A
L
K
F
A
K
E
I
Q
N
----
I
H
K
R
S
E
A
L
K
A
I
A
L
E
L
V
R
R
K
K
F
E
E
V
K
K
I
I
E
S
I
P
D
P
K
I
R
E
E
A
L
N
E
I
G
T
IE
27
Fugue
83.38
22%
-45
- C4 -
4OOU
1
?
A:
[20-383]
---------------------------------
S
E
F
L
K
A
S
G
S
N
F
Y
Y
G
G
Q
K
V
F
L
S
G
V
N
F
--------------
A
W
R
S
Y
G
S
D
F
G
N
G
Q
Y
A
S
N
G
P
A
L
--
K
D
W
I
N
K
V
K
A
S
G
G
N
T
A
R
V
W
V
H
V
E
G
Q
----------------------------
V
S
P
A
F
D
S
H
G
F
V
T
S
T
D
---------
S
K
K
T
L
I
N
D
L
S
D
L
L
D
Y
A
N
-
G
Q
N
V
F
L
I
-
L
V
L
F
N
--
G
A
L
--------------------------
Q
N
N
S
N
V
Q
N
L
F
W
D
E
S
K
L
N
S
Y
I
N
N
A
L
T
P
M
V
N
A
L
K
S
KP
S
L
A
A
W
E
V
L
N
E
P
E
G
T
L
Q
P
G
S
D
QNSCY
D
T
S
T
L
A
A
Q
G
A
G
------
W
G
G
K
K
F
P
M
K
Q
I
L
K
T
I
N
W
I
S
S
A
-------
I
H
N
A
D
S
K
-------
A
L
V
T
V
G
S
WSELTQTDSFGY
R
N
H
Y
-
K
--
D
S
C
L
T
G
A
G
G
K
S
N
G
IIN
F
Y
Q
M
H
T
Y
S
H
-----
S
G
K
W
N
Q
N
A
P
F
K
V
N
R
W
A
Y
N
V
N
D
K
P
L
L
I
G
E
F
A
S
V
C
S
-------------------
Q
N
E
G
-----
I
Q
N
L
Y
K
Y
A
Y
N
-
N
G
Y
N
-----
G
A
L
T
-
W
Q
F
N
S
G
GDCS
D
T
Y
S
N
Q
M
Y
G
M
Q
---
A
L
K
G
Q
N
D
Q
S
G
G
K
G
G
M
-
V
S
V
---------
N
I
N
H
--
2
PsiBlast_PDB
56.18
30%
-18
- C5 -
4H8W
1
?
L:
[62-145]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
F
S
G
S
K
S
--
G
N
T
A
S
L
T
I
S
G
L
Q
A
E
D
----------
E
A
D
Y
Y
C
S
S
Y
A
G
S
T
T
F
R
V
F
G
G
G
T
K
L
T
V
R
G
Q
P
K
A
A
P
S
V
T
L
-------
F
P
P
S
S
E
E
LQANKAT
L
V
C
L
I
--------------
S
D
F
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
55.11
30%
-18
- C5 -
3TNN
4
?
L:
[62-145]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
F
S
G
S
K
S
--
G
N
T
A
S
L
T
I
S
G
L
Q
A
E
D
----------
E
A
D
Y
Y
C
S
S
Y
A
G
S
T
T
F
R
V
F
G
G
G
T
K
L
T
V
R
G
Q
P
K
A
A
P
S
V
T
L
-------
F
P
P
S
S
E
E
LQANKAT
L
V
C
L
I
--------------
S
D
F
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.39
29%
-9
- C5 -
3MJ9
-
?
L:
[58-145]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
H
F
S
G
S
N
S
--
G
N
M
A
T
L
T
I
S
K
A
Q
A
G
D
----------
E
A
D
Y
Y
C
Q
S
W
D
G
T
N
S
A
W
V
F
G
S
G
T
K
V
T
V
L
G
Q
P
N
A
A
P
S
V
T
L
FPPSSEE
L
K
T
N
Q
A
T
-------
L
V
C
M
I
--------------
N
G
F
Y
P
A
--
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
50.82
17%
22
- C4 -
4RFX
-
DCTN1_CHICK
A:
[432-531]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
E
T
L
T
E
R
N
L
D
L
E
E
K
V
R
-
E
L
R
E
T
V
G
D
L
E
A
M
N
--
E
M
N
D
E
L
Q
E
N
A
R
E
T
E
L
E
L
R
E
Q
L
D
L
A
A
A
R
V
R
E
A
E
K
R
V
E
A
A
----
Q
E
T
V
A
D
Y
Q
Q
T
I
K
K
Y
R
E
L
T
A
H
--
L
Q
D
V
N
R
E
L
M
S
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.36
27%
-28
- C5 -
2VIS
1
HEMA_I68A0
B:
[85-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
T
D
D
T
A
-------
M
Y
Y
C
A
--------------
R
D
F
Y
D
Y
--
D
V
F
Y
Y
A
M
D
Y
W
G
Q
G
----
T
S
V
T
V
S
S
A
K
T
T
P
P
S
V
Y
P
L
A
P
G
S
A
A
Q
T
N
S
M
V
T
L
G
C
--
L
V
K
G
Y
F
P
E
P
V
T
V
T
W
N
-
S
G
S
L
S
S
G
V
H
-
T
F
P
---------------------------------------------------------------------------------------------
8
PsiBlast_PDB
50.32
27%
-27
- C5 -
2VIT
1
?
B:
[85-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
T
D
D
T
A
-------
M
Y
Y
C
A
--------------
R
D
F
Y
D
Y
--
D
V
F
Y
Y
A
M
D
Y
W
G
Q
G
----
T
S
V
T
V
S
S
A
K
T
T
P
P
S
V
Y
P
L
A
P
G
S
A
A
Q
T
N
S
M
V
T
L
G
C
--
L
V
K
G
Y
F
P
E
P
V
T
V
T
W
N
-
S
G
S
L
S
S
G
V
H
-
T
F
P
---------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.01
27%
-24
- C5 -
2VIR
1
B:
[85-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
T
D
D
T
A
-------
M
Y
Y
C
A
--------------
R
D
F
Y
D
Y
--
D
V
F
Y
Y
A
M
D
Y
W
G
Q
G
----
T
S
V
T
V
S
S
A
K
T
T
P
P
S
V
Y
P
L
A
P
G
S
A
A
Q
T
N
S
M
V
T
L
G
C
--
L
V
K
G
Y
F
P
E
P
V
T
V
T
W
N
-
S
G
S
L
S
S
G
V
H
-
T
F
P
---------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.26
29%
-8
- C5 -
3MJ8
-
?
L:
[59-147]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
H
F
S
G
S
N
S
--
G
N
M
A
T
L
T
I
S
K
A
Q
A
G
D
----------
E
A
D
Y
Y
C
Q
S
W
D
G
T
N
--
W
V
F
G
S
G
T
K
V
T
V
-
G
Q
P
N
A
A
P
S
V
T
L
FPPSSEE
L
K
T
N
Q
A
T
-------
L
V
C
M
I
--------------
N
G
F
Y
P
A
--
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
49.21
20%
13
- C4 -
4AJ5
-
SKA1_HUMAN
A:
[3-81]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
L
E
Q
L
C
S
H
V
N
E
K
I
G
-
N
I
K
K
T
L
S
-
L
R
N
C
G
QE
P
T
L
K
T
V
L
N
K
I
G
D
E
I
I
V
I
N
E
L
L
N
K
L
E
L
E
I
Q
Y
Q
E
Q
T
N
N
S
L
----
K
E
L
C
E
S
L
E
E
D
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
48.99
27%
-32
- C5 -
1GIG
-
?
H:
[85-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
T
D
D
T
A
-------
M
Y
Y
C
A
--------------
R
D
F
Y
D
Y
--
D
V
F
Y
Y
A
M
D
Y
W
G
Q
G
----
T
S
V
T
V
S
S
A
K
T
T
P
P
S
V
Y
P
L
A
P
G
S
A
A
Q
T
N
S
M
V
T
L
G
C--
L
V
K
G
Y
F
P
E
P
V
T
V
T
W
N
-
S
G
S
L
S
S
G
V
H
-
T
F
P
---------------------------------------------------------------------------------------------
9
PsiBlast_PDB
46.90
28%
-42
- C5 -
4OM1
-
?
H:
[101-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
T
A
--------------
R
D
Y
Y
N
W
--
D
-----
F
E
H
W
G
Q
G
----
T
P
V
T
V
S
S
A
S
T
K
G
P
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
L
G
C--
L
V
K
D
Y
F
P
E
P
V
T
V
S
W
N
-
S
G
A
L
------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
46.77
28%
-38
- C5 -
4OLW
-
?
H:
[101-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
T
A
--------------
R
D
Y
Y
N
W
--
D
-----
F
E
H
W
G
Q
G
----
T
P
V
T
V
S
S
A
S
T
K
G
P
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
L
G
C--
L
V
K
D
Y
F
P
E
P
V
T
V
S
W
N
-
S
G
A
L
------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
46.60
28%
-40
- C5 -
4OLX
1
?
H:
[101-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
T
A
--------------
R
D
Y
Y
N
W
--
D
-----
F
E
H
W
G
Q
G
----
T
P
V
T
V
S
S
A
S
T
K
G
P
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
L
G
C--
L
V
K
D
Y
F
P
E
P
V
T
V
S
W
N
-
S
G
A
L
------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
46.39
28%
-43
* C5 *
4OLY
1
?
H:
[101-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
T
A
--------------
R
D
Y
Y
N
W
--
D
-----
F
E
H
W
G
Q
G
----
T
P
V
T
V
S
S
A
S
T
K
G
P
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
L
G
C--
L
V
K
D
Y
F
P
E
P
V
T
V
S
W
N
-
S
G
A
L
------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
46.05
28%
-45
- C5 -
4OLU
-
?
H:
[101-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
T
A
--------------
R
D
Y
Y
N
W
--
D
-----
F
E
H
W
G
Q
G
----
T
P
V
T
V
S
S
A
S
T
K
G
P
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
L
G
C--
L
V
K
D
Y
F
P
E
P
V
T
V
S
W
N
-
S
G
A
L
------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.75
28%
-45
- C5 -
4OLZ
-
?
H:
[101-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
T
A
--------------
R
D
Y
Y
N
W
--
D
-----
F
E
H
W
G
Q
G
----
T
P
V
T
V
S
S
A
S
T
K
G
P
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
L
G
C--
L
V
K
D
Y
F
P
E
P
V
T
V
S
W
N
-
S
G
A
L
------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
45.53
28%
-39
- C5 -
4OLV
-
?
H:
[101-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
T
A
--------------
R
D
Y
Y
N
W
--
D
-----
F
E
H
W
G
Q
G
----
T
P
V
T
V
S
S
A
S
T
K
G
P
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
L
G
C--
L
V
K
D
Y
F
P
E
P
V
T
V
S
W
N
-
S
G
A
L
------------------------------------------------------------------------------------------------------