@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0172: (2016-04-20 )
MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKLTNNTVVAYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPANASAVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRDSVSHIIDELGPTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALNALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNKNLAEFTDRLTHSDADLSNAIQQFDSLLAVARPFFAKNREVLTHDVNNLATVTTTLLQPDPLDGLETVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFANPMEFICSSIQAGSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEIAYSEPRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQGLLTPESLAELMGGPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIPPPPPGPDVIPGPVPPTPAPVGAPLPAEAGGGQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150...-----....160.......170.......180.......190.......200....--...210........220.......230.......240.......250-.........260......---.270.......280....-...290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
T
I
F
D
IRNLRLPQLS
R
A
S
V
V
I
G
S
L
V
V
V
L
A
L
A
A
G
I
V
G
V
R
L
Y
Q
K
LTNN
T
V
V
A
Y
F
TQA
N
A
L
Y
VG
D
K
V
Q
I
M
GLPVGSIDKIEPAGD
K
M
K
V
T
F
H
YQ
N
K
YKVPANA
S
A
V
I
LNP
T
L
V
ASR
N
I
Q
LEPPYRGG
P
V
LADN
A
V
I
P
V
ERTQVPT
E
W
D
E
L
R
D
S
V
S
H
I
-----
I
D
ELGPTPEQPKG
P
F
G
E
V
I
E
A
F
ADGLAGKGK
Q
I
N
T
T
L
N
S
L
S
Q
A
L
N
A
L
N
EGR--
G
D
F
F
-
A
V
V
R
S
L
A
L
F
V
N
A
LHQD
D
Q
Q
F
V
A
L
N
K
N
L
A
E
F
T
D
R
LTHSDA
D
---
L
S
N
A
I
Q
Q
F
D
S
L
L
A
V
A
R
P
F
---
F
AKN
R
E
V
L
T
HDVN
N
L
A
T
V
-
T
T
TLLQPDPL
D
G
L
E
T
V
L
H
I
F
P
T
L
A
A
N
I
N
Q
LYHPTHG
G
V
V
S
L
S
A
F
TNFA
N
P
M
E
F
I
C
S
S
I
QAGSRLG
Y
Q
E
S
A
E
L
C
A
Q
Y
L
A
P
V
L
D
A
I
KFN
Y
F
PFGLNVA
S
T
A
ST
L
P
K
E
IAYSEPRLQPPNGYKDTTVP
G
I
WVPDTPLSHRNTQP
G
W
V
VAPGMQG
V
Q
VGPITQGLL
T
P
E
S
L
A
E
L
MGGPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIPPPPPGPDVIPGPVPPTPAPVGAPLPAEAGGGQ
8
PsiBlast_PDB
70.85
31%
35
- C5 -
4PTS
-
?
A:
[241-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
A
V
Y
H
G
H
F
K
C
N
---
R
S
K
L
S
E
M
P
V
L
W
A
Y
A
R
D
L
F
Q
T
P
-
G
F
G
D
T
T
D
F
T
Q
I
K
Q
H
Y
Y
I
V
H
S
D
I
N
P
-------
T
Q
I
V
P
K
G
P
D
L
R
N
W
L
T
P
H
H
R
E
E
L
G
G
R
P
------
F
G
D
G
T
P
P
G
P
P
I
A
----------------------------------------------------
37
Fugue
69.37
18%
-66
- C5 -
3F2E
1
?
A:
[8-90]
------------------------------------------------------------------------------------------------------------------------------------------------
F
T
A
V
A
E
Q
V
S
A
V
-----
L
S
Q
Y
G
I
T
-----
G
P
N
R
A
I
Y
Q
G
F
G
L
K
V
A
R
A
L
N
R
L
G
G
G
-
P
A
L
V
N
M
I
N
G
L
K
A
Y
Y
--
I
S
A
F
N
A
N
P
T
V
L
D
A
V
T
D
I
I
T
G
S
P
T
G
Y
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
63.59
14%
22
- C5 -
1NYH
-
SIR4_YEAST
A:
[1271-1346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
V
D
I
V
L
S
K
A
A
S
A
L
D
E
K
E
--
K
Q
L
A
-
V
A
N
E
I
I
R
S
L
S
D
E
V
M
R
N
E
I
R
I
T
S
L
Q
G
D
L
T
F
T
K
K
C
L
E
N
A
R
S
Q
---
I
S
E
K
D
A
K
I
N
K
L
M
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.45
34%
24
- C5 -
2NUD
2
AVRB_PSESG
A:
[145-201]
---------------------------------------------------------------------------------------------------
D
A
H
D
E
I
M
Q
D
N
L
F
G
D
L
N
V
K
V
---
Y
R
Q
T
A
Y
L
H
G
N
-
V
I
P
L
N
T
F
R
V
A
T
D
T
E
Y
L
R
D
R
V
A
H
L
-----
R
T
E
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.33
34%
24
- C5 -
1NH1
-
AVRB_PSESG
A:
[143-199]
---------------------------------------------------------------------------------------------------
D
A
H
D
E
I
M
Q
D
N
L
F
G
D
L
N
V
K
V
---
Y
R
Q
T
A
Y
L
H
G
N
-
V
I
P
L
N
T
F
R
V
A
T
D
T
E
Y
L
R
D
R
V
A
H
L
-----
R
T
E
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
62.93
10%
-43
- C5 -
4UY3
-
EZRA_STAA1
A:
[23-216]
----------------------------------------------------------------------------------------------------------------------------------------
M
R
S
N
K
R
Q
I
I
E
K
A
I
E
R
K
N
E
I
E
T
LP
F
D
Q
N
L
A
Q
L
S
K
L
N
L
K
--
G
E
T
K
T
K
Y
D
A
M
K
K
D
N
V
E
S
T
N
K
Y
L
A
P
V
E
E
K
I
H
N
A
E
A
L
L
D
K
F
S
F
N
-
A
S
Q
S
E
I
D
D
A
N
E
L
M
D
S
Y
E
Q
S
Y
Q
Q
Q
L
E
D
V
N
E
I
I
A
L
Y
K
D
N
D
E
L
Y
D
K
C
K
V
D
Y
R
E
M
K
R
D
V
L
A
N
R
H
Q
---
F
G
E
A
A
S
L
L
E
T
E
I
E
K
F
E
P
R
-
L
E
Q
Y
E
V
L
K
A
D
G
N
Y
V
Q
A
H
N
H
I
A
A
L
N
E
Q
M
K
Q
L
R
S
Y
M
H
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.32
34%
17
- C5 -
2NUN
-
AVRB_PSESG
A:
[145-201]
---------------------------------------------------------------------------------------------------
D
A
H
D
E
I
M
Q
D
N
L
F
G
D
L
N
V
K
V
---
Y
R
Q
T
A
Y
L
H
G
N
-
V
I
P
L
N
T
F
R
V
A
T
D
T
E
Y
L
R
D
R
V
A
H
L
-----
R
T
E
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
60.81
9%
9
- C5 -
2V66
1
NDEL1_HUMAN
B:
[1-111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
Q
R
N
R
D
L
Q
A
D
N
Q
R
L
K
Y
E
V
E
A
L
K
E
K
L
E
H
Q
Y
A
Q
S
Y
K
Q
V
S
V
L
E
D
D
L
--
S
Q
T
R
-
A
I
K
E
Q
L
H
K
Y
V
R
E
L
E
Q
A
N
D
D
L
E
R
A
K
R
A
T
I
V
S
L
E
D
F
E
Q
R
L
N
Q
---
A
I
E
R
N
A
F
L
E
S
E
L
D
E
K
E
S
L
---
L
V
S
V
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.63
31%
50
- C7 -
1W50
1
BACE1_HUMAN
A:
[18-82]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
E
M
V
D
N
L
R
-
G
K
S
G
Q
G
Y
Y
V
E
M
T
V
G
S
P
P
Q
T
L
N
I
L
V
D
T
G
--
S
S
N
F
-
A
V
G
A
A
P
H
P
F
L
H
R
Y
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
57.39
31%
51
* C7 *
3RSX
2
BACE1_HUMAN
A:
[18-84]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
E
M
V
D
N
L
R
-
G
K
S
G
Q
G
Y
Y
V
E
M
T
V
G
S
P
P
Q
T
L
N
I
L
V
D
T
G
--
S
S
N
F
-
A
V
G
A
A
P
H
P
F
L
H
R
Y
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
57.09
12%
23
- C5 -
3OKQ
-
BUD6_YEAST
A:
[553-677]
--------------------------------------------------------------------------------------------------------------------------------------
S
S
N
R
M
Y
M
E
K
S
Q
T
E
L
G
D
L
S
D
T
L
-----
L
S
K
V
D
D
L
Q
D
V
I
E
I
M
R
K
D
V
A
E
R
R
S
Q
P
A
K
K
K
L
E
T
V
S
K
D
L
E
N
A
Q
A
D
V
L
K
L
Q
E
F
I
--
D
T
E
K
-
P
H
W
K
K
T
W
E
A
E
L
D
K
V
C
E
E
Q
Q
F
L
T
L
Q
E
E
L
I
L
D
L
K
E
D
L
G
K
A
L
E
---
T
F
D
L
I
K
L
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
56.94
31%
56
- C7 -
3RU1
5
BACE1_HUMAN
A:
[18-96]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
E
M
V
D
N
L
R
-
G
K
S
G
Q
G
Y
Y
V
E
M
T
V
G
S
P
P
Q
T
L
N
I
L
V
D
T
G
--
S
S
N
F
-
A
V
G
A
A
P
H
P
F
L
H
R
Y
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
56.94
31%
58
- C7 -
3RTN
6
BACE1_HUMAN
A:
[18-92]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
E
M
V
D
N
L
R
-
G
K
S
G
Q
G
Y
Y
V
E
M
T
V
G
S
P
P
Q
T
L
N
I
L
V
D
T
G
--
S
S
N
F
-
A
V
G
A
A
P
H
P
F
L
H
R
Y
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
56.66
31%
49
- C7 -
1W51
1
BACE1_HUMAN
A:
[18-85]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
E
M
V
D
N
L
R
-
G
K
S
G
Q
G
Y
Y
V
E
M
T
V
G
S
P
P
Q
T
L
N
I
L
V
D
T
G
--
S
S
N
F
-
A
V
G
A
A
P
H
P
F
L
H
R
Y
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.64
31%
47
- C7 -
3RSV
6
BACE1_HUMAN
A:
[18-95]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
E
M
V
D
N
L
R
-
G
K
S
G
Q
G
Y
Y
V
E
M
T
V
G
S
P
P
Q
T
L
N
I
L
V
D
T
G
--
S
S
N
F
-
A
V
G
A
A
P
H
P
F
L
H
R
Y
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
56.30
31%
46
- C7 -
3RTH
1
BACE1_HUMAN
A:
[18-88]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
E
M
V
D
N
L
R
-
G
K
S
G
Q
G
Y
Y
V
E
M
T
V
G
S
P
P
Q
T
L
N
I
L
V
D
T
G
--
S
S
N
F
-
A
V
G
A
A
P
H
P
F
L
H
R
Y
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.60
31%
56
- C7 -
3RTM
4
BACE1_HUMAN
A:
[18-90]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
E
M
V
D
N
L
R
-
G
K
S
G
Q
G
Y
Y
V
E
M
T
V
G
S
P
P
Q
T
L
N
I
L
V
D
T
G
--
S
S
N
F
-
A
V
G
A
A
P
H
P
F
L
H
R
Y
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
54.91
16%
38
- C5 -
5DOL
-
YABA_BACSU
A:
[2-62]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
K
E
L
F
D
T
V
I
N
L
E
E
Q
I
--
G
S
L
Y
-
R
Q
L
G
D
L
K
Q
H
I
G
E
M
I
E
E
N
H
H
L
Q
L
E
N
K
H
L
R
K
R
L
D
D
T
T
Q
Q
I
E
K
---
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
52.69
23%
82
- C5 -
3EFG
1
SLYX_XANCP
A:
[8-58]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Q
E
L
E
A
R
L
V
E
L
E
T
R
L
S
F
---
Q
E
Q
A
L
T
E
L
S
E
A
L
A
D
A
R
L
T
---
G
A
R
N
A
E
L
I
R
H
L
L
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
51.63
21%
89
- C5 -
1UIX
-
ROCK2_BOVIN
A:
[-2-1045]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
D
V
A
N
L
A
N
E
K
E
E
L
N
N
K
L
K
E
A
Q
E
Q
---
L
S
R
L
K
D
E
E
I
S
A
A
A
I
K
A
Q
F
E
K
Q
L
L
T
E
R
T
L
K
T
Q
A
V
N
K
L
A
E
I
M
N
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------