@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0173: (2016-04-20 )
MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPDPSPVPLKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFLTGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC
Atome Classification :
(20 SA)
-------------......----...10....----....--------------------20..--......30.......--.40........50.....--------...-60....-....70........80...--....--.90........100.......110.....-..120--.......130.......140.......150.......160.--.....------.170.......180.-....---..---------190.--.-----------.--..--..200.......210..-----......220.-----......230------------.......240...---.-...250........260....---------------...270.......280.......290.......300.......310.......-----320...-----....330.......340.......350...-----....360.......370.--......380.......390--------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------
M
M
S
V
L
A
----
R
M
R
V
M
R
H
R
A
----
W
Q
G
L
--------------------
V
L
L
V
--
L
A
L
L
L
S
SCGWRGISN--VAIPGGPGTGPG
S
Y
T
I
Y
V
--------QMP-
D
T
L
A
IN-GN
S
R
V
M
V
A
D
V
W
VG
S
I
R
A
I
K
--LK
N
W
--
V
A
T
L
T
L
S
LKKDVTLPKNATAKIGQTSLLG-SQ
H
V
E
--LAAPPDPSPVPLKDGDTIPLKRSSAYP
T
T
E
Q
T
L
A
S
I
A
T
L
L
R--GG
G
L
V------
N
L
E
G
I
Q
Q
E
I
N
A
I
VTG-
R
A
D
Q
---
I
R
---------
A
F
L
G--K-----------L--
D
T
--
F
T
D
E
L
N
Q
Q
R
D
D
I
T
R
-
A
I
-----DSTN
R
L
L
A
YV-----G
G
R
S
E
V
L
N
R
------------
V
L
TD
L
P
P
L
I
K
H
FA---
D
-
K
Q
E
L
L
-
I
NA
S
D
A
V
G
R
L
S
Q
S
A
D
---------------
Q
Y
L
S
A
AR
G
D
L
H
Q
D
L
Q
A
L
Q
C
P
L
K
E
L
R
R
A
A
P
Y
L
V
G
A
L
K
L
I
LTQPFD
V
D
T
V
P
Q
L
V
R-----GDY
M
N
L
-----
S
L
T
L
D
L
T
Y
S
AID
N
A
F
LTGTG
F
S
G
A
L
R
A
L
E
Q
-----
S
FGRDPETMIPD
I
R
YTPN--PNDAPGGPLVERGNRQC----------------------------------------
37
Fugue
84.12
19%
-34
- C3 -
4WW4
1
?
A:
[3-458]
-------------
Q
I
S
E
V
R
G
N
T
R
D
H
R
T
A
A
H
T
H
----
I
K
G
L
GLNSSGIAEKQAAGFVGQ
C
A
A
R
E
A
--
C
G
V
V
V
D
L
I
K
A
H
K
M
A
G
R
G
V
L
L
A
G
G
P
G
T
G
--
K
T
A
L
A
L
--------
A
I
S
-
Q
E
L
G
T
K
I
P
F
C
P
I
T
G
S
E
I
Y
S
T
E
V
K
K
T
E
V
L
M
E
N
F
R
R
A
I
G
L
R
V
R
E
T
K
D
V
Y
E
G
E
V
S
T
L
L
I
G
L
K
S
A
R
G
--
Q
K
L
D
--
Q
K
E
R
V
Q
V
G
D
V
I
Y
I
E
T
N
T
G
A
C
-
R
S
D
A
Y
A
T
E
F
D
L
E
A
E
E
Y
V
P
I
P
--
K
G
E
V
H
------
K
K
K
E
I
V
Q
D
V
T
L
H
D
L
D
-
V
A
N
A
RPD
I
I
---------
S
M
M
G
--
Q
-----------
L
MK
P
K
--
M
T
E
I
T
D
K
L
R
M
E
I
N
K
-
V
V
-----
Q
K
Y
I
N
-----------------
Q
G
------------
V
A
E
L
I
P
G
V
L
--
F
I
---
D
-
E
A
H
M
L
D
I
E
C
F
T
Y
L
N
K
A
L
E
S
P
I
---------------
A
P
I
V
V
L
A
S
N
R
G
I
A
T
I
R
G
A
D
D
L
K
A
A
H
G
I
P
P
D
F
L
Q
R
L
L
I
I
P
T
H
P
Y
E
P
D
E
I
R
R
I
V
R
-----
I
R
A
Q
T
E
-----
G
V
--
Q
L
T
D
A
A
V
D
R
V
A
E
H
G
V
R
I
S
--
L
R
Y
C
L
Q
-----
L
L
A
P
A
S
I
L
A
R
V
N
G
R
T
Q
V
D
--
V
Q
D
I
A
E
A
E
E
L
F
L
D
A
R
R
S
A
N
I
L
T
S
TGGLH-----------------------------
36
Fugue
69.08
11%
-40
- C4 -
2XU0
6
?
A:
[12-487]
SPTLSESHKS
A
R
N
V
L
E
N
I
G
----
I
K
I
Y
N
Q
E
I
K
----
K
K
N
P
--------------------
Y
E
Q
Q
--
L
K
G
T
L
D
G
N
S
C
N
L
D
H
L
--
F
G
R
K
P
C
Y
G
R
E
Q
N
R
F
D
E
N
A
--------
E
A
Y
C
N
S
D
K
I
R
-
G
N
E
N
N
A
N
G
A
A
C
A
P
P
R
R
R
-----
H
I
C
--
D
Q
N
L
E
F
L
D
N
K
N
T
N
T
A
H
D
L
L
G
N
V
L
V
T
A
K
Y
E
-
G
N
Y
I
V
--
N
D
H
P
D
K
N
S
N
----------
G
N
K
A
G
I
C
T
S
L
A
R
S
F
A
D
I
G
D
I
V
R
--
G
R
D
M
F
LPN---
K
D
D
K
V
Q
K
G
L
Q
V
V
F
K
K
-
I
Y
K
S
---
L
T
---------
P
E
A
R
--
K
H
Y
AHGDGSGN
Y
A
--
K
L
--
R
E
D
W
W
T
I
N
R
E
Q
I
W
K
-
A
L
T
C
SAP
Y
Y
A
D
Y
F
R
K
G
S
-----
D
G
T
L
H
F
S
S
H
GKCGHNEGAPPT
Y
L
D
Y
V
P
Q
F
L
R
W
F
E
---
E
W
S
E
E
F
C
-
R
I
K
K
I
K
I
D
K
V
K
K
E
C
R
DEQNK
K
Y
C
S
GDGHDC
T
Q
T
N
L
A
H
N
Q
I
F
V
D
L
D
C
P
R
C
-
Q
D
Q
C
I
K
Y
N
E
W
I
V
K
K
L
E
E
F
Y
K
Q
N
L
K
Y
S
M
E
I
Q
K
W
K
K
TKNN
Y
Y
D
K
E
F
-----
Y
E
N
L
D
K
K
S
Y
S
T
I
D
K
F
L
N
L
L
N
N
G
K
H
C
H
D
N
K
D
EKNKI
D
F
N
K
P
I
K
T
F
S
I
S
E
Y
C
K
T
------
C
P
L
Y
G
V
T
C
T
N
R
G
I
C
I
H
N
S------------------------------------
33
Fugue
61.84
17%
-74
- C5 -
1AEP
-
APL3_LOCMI
A:
[6-158]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
A
E
A
V
Q
Q
L
N
H
T
I
V
N
-
A
A
H
E
---
L
H
---------
E
T
L
G
LP
T
-----------
P
--
D
E
--
A
L
N
L
L
T
E
Q
A
N
A
F
K
T
-
K
I
-----
A
E
V
T
T
S
L
K
Q
E
A
E
K
H
Q
G
S
V
A
E
Q
L
N
A
------------
F
A
R
N
L
N
N
S
I
H
D
A
A
TSL
N
-
L
Q
D
Q
L
-
N
S
L
Q
S
A
L
T
N
V
G
H
Q
W
Q
---------------
D
I
A
T
K
T
Q
A
S
A
Q
E
A
W
A
P
V
Q
S
A
L
Q
E
A
A
E
K
T
K
E
A
A
A
N
L
Q
N
S
I
Q
S
A
V
Q
K
----------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
52.12
9%
-60
* C5 *
3FX7
-
?
A:
[5-88]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
D
T
E
E
------------
V
R
E
F
V
G
H
L
E
R
F
K
E
---
L
-
L
R
E
E
V
-
N
S
L
S
N
H
F
H
N
L
E
S
W
R
D
---------------
A
R
R
D
K
F
S
E
V
L
D
N
L
K
S
T
F
N
E
F
D
E
A
A
Q
E
Q
I
A
W
L
K
E
R
I
R
V
L
E
E
D
Y
L
E
-----------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
51.57
23%
-15
- C5 -
2A3D
-
?
A:
[1-73]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
S
W
A
E
F
K
Q
R
L
A
A
I
K
T
R
L
Q
AL
G
G
S
E
A
------
E
L
A
A
F
E
K
E
I
A
A
F
-----
E
S
E
---
L
Q
---------
A
Y
K
G
--
K
-----------
G
--
N
P
--
E
V
E
A
L
R
K
E
A
A
A
I
R
D
-
E
L
-----
Q
A
Y
R
H
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
49.56
15%
-15
- C5 -
4CPC
-
SYCP3_HUMAN
A:
[81-223]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
K
A
L
L
A
K
R
K
R
L
E
--
M
Y
T
K
A
------
S
L
K
T
S
N
Q
K
I
E
H
V
W
K
T
-
Q
Q
D
Q
---
R
Q
---------
K
L
N
Q
--
E
-----------
Y
S
-
Q
Q
--
F
L
T
L
F
Q
Q
W
D
L
D
M
Q
K
-
A
E
-----
E
Q
E
E
K
I
L
N
M
F
-----
R
Q
Q
Q
K
I
L
Q
Q
------------
S
R
I
V
Q
S
Q
R
L
K
T
I
K
---
Q
-
L
Y
E
Q
F
-
I
K
S
M
E
E
---
L
E
K
N
H
D
---------------
N
L
L
T
G
A
Q
N
E
F
K
K
E
M
A
M
L
Q
K
K
I
M
M
E
T
Q
Q
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
49.45
8%
-23
- C2 -
4DVZ
-
CAGA_HELPY
A:
[308-829]
-------------
L
M
G
S
H
N
----
G
K
V
S
L
L
Y
A
G
DKHD
W
N
A
T
--------------------
V
G
Y
K
DN
V
A
T
L
I
N
V
H
M
K
N
G
S
G
L
--
V
I
A
G
G
E
K
G
I
N
N
P
S
F
Y
L
Y
K
E
D
QLTG
S
Q
R
A
L
-
S
Q
E
E
I
R
-
N
K
V
D
F
M
E
F
L
A
Q
N
N
T
K
L
D
N
L
--
S
E
K
E
--
K
E
K
F
Q
N
E
I
E
D
F
Q
K
D
S
K
A
Y
L
D
A
L
G
N
D
R
I
A
F
V
S
K
K
D
T
KH
S
A
L
I
T
E
F
N
N
G
D
L
S
Y
T
L
K
D
Y
E
K
N
V
T
L
Q
G
S
L
K
H
D
G
V
M
F
V
D
Y
S
F
--
N
K
V
A
V
F
NLPDL
N
N
L
A
I
T
S
F
V
R
R
N
L
E
N
-
K
L
T
A
---
K
G
---------
L
S
L
Q
--
E
-----------
A
--
N
K
--
L
I
K
D
F
L
S
S
N
K
E
L
A
G
-
K
A
-----
L
N
F
N
K
A
V
A
E
A
-----
K
S
T
G
N
-
Y
D
E
------------
V
K
K
A
Q
K
D
L
E
K
S
L
R
---
K
-
R
E
H
L
E
-
K
E
V
E
K
K
L
E
S
K
S
G
N
K
K
---------------
A
Q
A
N
S
Q
K
D
E
I
F
A
L
I
N
K
E
A
N
R
D
A
R
A
I
A
Y
T
Q
N
L
K
G
I
K
R
E
L
S
D
K
L
E
K
I
S
K
D
L
K
D
F
S
-----
K
S
F
D
E
F
K
NFSK
A
E
E
T
L
K
A
L
K
G
S
V
K
D
L
G
I
N
P
E
W
I
S
K
V
E
N
L
N
A
-----
A
L
N
E
F
K
N
G
D
F
S
K
V
T
Q
A
K
S
D
L
E
N
S
V
K
D
V
I
I
N
Q
K
V
T
D
K
V
D
N
L
N
Q
A
V
S
V
A
K
A
M
GDF
S
R
V
E
Q
V
L
A
D
L
K
N
F
S
K
E
Q
L
A
Q
Q
A
Q
K
21
HHSearch
49.36
9%
-36
- C5 -
4UY3
-
EZRA_STAA1
A:
[81-191]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
P
V
E
E
K
I
H
N
A
E
A
L
L
D
--
K
F
S
F
N
------
A
S
Q
S
E
I
D
D
A
N
E
L
M
D
S
-
Y
E
Q
S
---
Y
Q
---------
Q
Q
L
E
--
D
-----------
V
--
N
E
--
I
I
A
L
Y
K
D
N
D
E
L
Y
D
K
-
C
K
-----
V
D
Y
R
E
M
K
R
D
V
-----
L
A
N
R
H
Q
F
G
E
------------
A
A
S
L
L
E
T
E
I
E
K
F
E
---
P
-
R
L
E
Q
Y
-
E
V
L
K
A
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
48.24
18%
22
- C5 -
2GTS
-
?
A:
[4-80]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
M
D
T
E
E
---
V
R
---------
E
F
V
G
--
H
-----------
L
--
E
R
--
F
K
E
L
L
R
E
E
V
N
S
L
S
N
-
H
F
--------
H
N
L
E
S
W
R
-----
D
A
R
R
D
K
F
S
E
------------
V
L
D
N
L
K
S
T
F
N
E
F
D
---
E
-
A
A
Q
E
Q
-
I
A
W
L
K
E
R
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
46.80
29%
-4
- C5 -
3WXM
-
PELO_AERPE
B:
[260-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
T
R
I
L
R
--
E
L
S
I
V
------
E
A
E
G
V
L
E
E
F
L
R
R
I
A
K
-
S
R
D
T
---
V
A
Y
T
P
G
E
V
L
A
V
A
R
M
G
--
A
-----------
V
--
D
T
V
L
L
V
D
T
L
L
H
S
P
D
D
A
V
R
E
A
V
-----
D
E
A
L
R
L
V
E
S
M
-----
G
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
43.19
13%
13
- C5 -
3U0C
-
IPAB_SHIFL
A:
[76-159]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
Q
L
T
L
L
I
G
N
L
I
Q
I
L
G
--
E
K
S
L
T
------
A
L
T
N
K
I
T
A
W
K
S
Q
Q
Q
A
-
R
Q
Q
K
---
N
L
---------
E
F
S
D
--
K
-----------
I
--
N
T
--
L
L
S
E
T
E
G
L
T
R
D
Y
E
K
-
Q
I
-----
N
K
L
K
N
A
D
S
K
I
-----
K
D
L
E
N
K
I
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
30.81
38%
61
- C5 -
4ZN2
-
?
A:
[84-127]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
T
A
E
D
---------------
Q
Y
Q
L
A
S
L
D
Q
L
V
K
D
L
E
A
R
Q
L
------
K
S
V
F
Y
L
V
G
S
A
R
F
I
T
T
A
P
F
------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
28.46
38%
61
- C5 -
5BXA
1
?
A:
[58-101]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
T
A
E
D
---------------
Q
Y
Q
L
A
S
L
D
Q
L
V
K
D
L
E
A
R
Q
L
------
K
S
V
F
Y
L
V
G
S
A
R
F
I
T
T
A
P
F
------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
25.98
38%
60
- C5 -
5BX9
-
?
A:
[58-101]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
T
A
E
D
---------------
Q
Y
Q
L
A
S
L
D
Q
L
V
K
D
L
E
A
R
Q
L
------
K
S
V
F
Y
L
V
G
S
A
R
F
I
T
T
A
P
F
------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
23.35
14%
147
- C5 -
1WYY
-
SPIKE_CVHSA
A:
[58-101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
T
L
V
K
Q
L
S
S
N
F
G
A
-
I
S
S
V
---
L
N
---------
D
I
L
S
--
R
-----------
L
--
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
16.75
39%
186
- C6 -
4OBR
-
IDUA_HUMAN
A:
[573-600]
---------------------------------------------------------------------------------------------
P
S
T
F
N
L
F
V
--------
F
S
P
-
D
T
G
A
V
S
-
G
S
Y
R
V
R
A
L
D
Y
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
16.58
39%
199
- C6 -
4KGJ
-
IDUA_HUMAN
A:
[573-600]
---------------------------------------------------------------------------------------------
P
S
T
F
N
L
F
V
--------
F
S
P
-
D
T
G
A
V
S
-
G
S
Y
R
V
R
A
L
D
Y
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
16.34
39%
199
- C6 -
4KGL
-
IDUA_HUMAN
A:
[573-600]
---------------------------------------------------------------------------------------------
P
S
T
F
N
L
F
V
--------
F
S
P
-
D
T
G
A
V
S
-
G
S
Y
R
V
R
A
L
D
Y
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_CBE
15.69
39%
198
* C6 *
4OBR
1
IDUA_HUMAN
B:
[573-600]
---------------------------------------------------------------------------------------------
P
S
T
F
N
L
F
V
--------
F
S
P
-
D
T
G
A
V
S
-
G
S
Y
R
V
R
A
L
D
Y
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_CBE
15.52
39%
191
- C6 -
4MJ2
2
IDUA_HUMAN
B:
[599-626]
---------------------------------------------------------------------------------------------
P
S
T
F
N
L
F
V
--------
F
S
P
-
D
T
G
A
V
S
-
G
S
Y
R
V
R
A
L
D
Y
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------