@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0183: (2016-04-20 )
MTTTRTERNFAGIGDVRIVYDVWTPDTAPQAVVVLAHGLGEHARRYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRDISEYTADFDTLVGIATREYPGCKRIVLGHSMGGGIVFAYGVERPDNYDLMVLSAPAVAAQDLVSPVVAVAAKLLGVVVPGLPVQELDFTAISRDPEVVQAYNTDPLVHHGRVPAGIGRALLQVGETMPRRAPALTAPLLVLHGTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVFNEPERNQVLDDVVAWLTERL
Atome Classification :
(20 SA)
-.........10........20....-....30-.........40-.--...--....-.50........60........70........80.......-.90........100.......110.......120...----....130-...-....140.-.-.----.-------------..-..150-..---......-.----160----.---------.-......170-.----.----.-.------....180......-..190-........------200------..--.--..--...210.......220.....-..230........240.......250.......260-..-..-....270.......--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MTTTRTERNFAGIG
D
V
R
I
V
Y
D
VWTP-DTAP
Q
--
A
V
V
V
L
A
H
G
L
G
--
E
--
H
A
R
--
R
Y
D
H
-
V
A
Q
R
LGAA
G
L
V
T
Y
A
LDHRGHGRSGG
K
R
V
L
V
R
D
I
S
E
YTA
D
F
-
D
T
L
V
G
IATREYPGC
K
R
I
V
L
GHSMGG
G
I
V
F
A
Y
GVERPD----NY
D
L
M
V
L-SA
P
-
A
V
A
A
Q
-
D
L
-
V
-
S
----
P
-------------
V
V
-
A
V
A
---
A
K
---
L
L
G
V
VV-P----GL-----P---------V-QE
L
D
F
TA-I-S----R----D-P------E
V
V
Q
AY-NTDPLV-HHGR--V
P
A
G
I
G
R
A
------
L
L
-------
Q
V
--G--ET--MPRRAPALT
A
P
L
L
V
L
HGTDD
R
-
L
I
PI-EGS
R
R
L
V
E
C
VGSAD
V
Q
L
K
EYP
G
L
Y
H
E
VFN-E-P
E
-
R
N
-
Q
V
L
D
D
V
V
A
W
L
TERL--
4
PsiBlast_PDB
96.61
36%
-111
- C1 -
3PE6
1
MGLL_HUMAN
A:
[35-293]
-----------------------
W
A
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
N
P
E
S
-
A
-
T
----
T
-------------
F
K
-
V
L
A
---
A
K
---
V
L
N
S
V
L
-
P
----
N
L
-----
S
---------
S
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
V
T
N
-
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
28
HHSearch
96.20
35%
-107
- C1 -
3PE6
1
MGLL_HUMAN
A:
[22-293]
----------
L
V
N
A
D
G
Q
Y
L
F
C
R
Y
W
A
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
N
-
P
E
-
S
A
T
----
T
-------------
F
K
-
V
L
A
---
A
K
---
V
L
N
S
V
L
-
P
----
N
L
-----
S
---------
S
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
-
V
T
N
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
3
PsiBlast_PDB
95.97
36%
-110
- C1 -
3HJU
1
MGLL_HUMAN
A:
[53-311]
-----------------------
W
K
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
N
P
E
S
-
A
-
T
----
T
-------------
F
K
-
V
L
A
---
A
K
---
V
L
N
L
V
L
-
P
----
N
L
-----
S
---------
L
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
V
T
N
-
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
2
PsiBlast_PDB
95.56
36%
-108
- C1 -
4UUQ
1
MGLL_HUMAN
A:
[52-310]
-----------------------
W
K
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
N
P
E
S
-
A
-
T
----
T
-------------
F
K
-
V
L
A
---
A
K
---
V
L
N
L
V
L
-
P
----
N
L
-----
S
---------
L
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
V
T
N
-
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
29
HHSearch
95.51
35%
-107
- C1 -
3HJU
1
MGLL_HUMAN
A:
[40-311]
----------
L
V
N
A
D
G
Q
Y
L
F
C
R
Y
W
K
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
N
-
P
E
-
S
A
T
----
T
-------------
F
K
-
V
L
A
---
A
K
---
V
L
N
L
V
L
-
P
----
N
L
-----
S
---------
L
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
-
V
T
N
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
5
PsiBlast_PDB
95.15
35%
-109
- C1 -
3JW8
4
MGLL_HUMAN
A:
[52-310]
-----------------------
W
K
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
N
P
E
S
-
A
-
T
----
T
-------------
F
K
-
V
L
A
---
A
K
---
V
L
N
L
V
L
-
P
----
N
L
-----
S
---------
L
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
V
T
N
-
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
22
PsiBlast_CBE
94.46
36%
-109
- C1 -
3JWE
2
MGLL_HUMAN
B:
[52-310]
-----------------------
W
K
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
N
P
E
S
-
A
-
T
----
T
-------------
F
K
-
V
L
A
---
A
K
---
V
L
N
L
V
L
-
P
----
N
L
-----
S
---------
L
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
V
T
N
-
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
21
PsiBlast_CBE
94.17
36%
-108
- C1 -
4UUQ
1
MGLL_HUMAN
B:
[52-310]
-----------------------
W
K
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
N
P
E
S
-
A
-
T
----
T
-------------
F
K
-
V
L
A
---
A
K
---
V
L
N
L
V
L
-
P
----
N
L
-----
S
---------
L
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
V
T
N
-
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
23
PsiBlast_CBE
94.14
36%
-106
- C1 -
3HJU
1
MGLL_HUMAN
B:
[53-311]
-----------------------
W
K
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
N
P
E
S
-
A
-
T
----
T
-------------
F
K
-
V
L
A
---
A
K
---
V
L
N
L
V
L
-
P
----
N
L
-----
S
---------
L
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
V
T
N
-
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
1
PsiBlast_PDB
89.01
36%
-109
- C1 -
3JWE
1
MGLL_HUMAN
A:
[52-310]
-----------------------
W
K
P
-
T
G
T
P
K
--
A
L
I
F
V
S
H
G
A
G
--
E
--
H
S
G
--
R
Y
E
E
-
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
V
S
D
F
H
V
F
V
R
D
V
-
L
Q
H
V
D
S
M
Q
K
D
Y
P
G
L
P
V
F
L
L
G
H
S
M
G
G
A
I
A
I
L
T
A
A
E
R
P
G
----
H
F
A
G
M
V
L
-
I
S
P
-
L
V
L
A
---------------------------------------------
L
-
P
----
N
L
-----
S
---------
L
-
G
P
I
D
S
S
V
-
L
-
S
----
R
----
N
-
K
------
T
E
V
D
I
Y
-
N
S
D
P
L
I
-
C
R
A
G
--
L
K
V
C
F
G
I
Q
------
L
L
-------
N
A
--
V
--
S
R
--
V
E
R
A
L
P
K
L
T
V
P
F
L
L
L
Q
G
S
A
D
R
-
L
C
D
S
-
K
G
A
Y
L
L
M
E
L
A
K
S
Q
D
K
T
L
K
I
Y
E
G
A
Y
H
V
L
H
K
-
E
L
P
E
V
T
N
-
S
V
F
H
E
I
N
M
W
V
S
Q
R
---
55
Fugue
71.65
19%
-103
- C1 -
2WTM
3
?
A:
[2-251]
-------
G
A
M
Y
I
D
C
D
G
I
K
L
N
A
Y
L
D
M
P
-
K
N
N
P
E
K
C
P
L
C
I
I
I
H
G
F
T
--
G
HS
E
E
R
--
H
I
V
A
-
V
Q
E
T
L
N
E
I
G
V
A
T
L
R
A
D
M
Y
G
H
G
K
S
D
G
K
F
E
D
H
-
T
L
F
K
W
L
T
N
I
-
L
A
V
V
D
Y
A
K
K
L
D
F
V
T
D
I
Y
M
A
G
H
S
Q
G
G
L
S
V
M
L
A
A
A
M
E
R
D
----
I
I
K
A
L
I
P
-
L
S
P
-
A
A
M
I
P
-
E
I
-
A
-
R
---------------------------------------------------------------------
T
-
G
-
E
----
L
----
L
-
G
------
L
K
F
D
P
E
-
N
I
P
D
E
L
-
D
A
W
D
---
G
R
K
L
K
G
N
------
Y
V
-------
R
V
--
A
--
Q
T
IR
V
E
D
F
V
D
K
Y
T
K
P
V
L
I
V
H
G
D
Q
D
E
-
A
V
P
Y
-
E
A
S
V
A
F
S
K
Q
Y
K
--
N
C
K
L
V
T
I
P
G
D
T
H
C
Y
---
D
-
H
H
-
L
E
-
L
V
T
E
A
V
K
E
F
M
L
E
Q
I
AK
44
HHSearch
69.99
18%
-115
- C1 -
3PFB
8
?
A:
[29-265]
-------------
R
D
G
L
Q
L
V
G
T
R
E
E
P
-
F
G
E
I
Y
--
D
M
A
I
I
F
H
G
F
T
--
A
--
N
R
N
T
S
L
L
R
E
-
I
A
N
S
L
R
D
E
N
I
A
S
V
R
F
D
F
N
G
H
G
D
S
D
G
K
F
-
E
N
M
T
V
L
N
E
I
E
D
A
-
N
A
I
L
N
Y
V
K
T
D
P
H
V
R
N
I
Y
L
V
G
H
A
Q
G
G
V
V
A
S
M
L
A
G
L
Y
P
D
----
L
I
K
K
V
V
L
-
L
A
P
-
A
A
T
L
K
-
G
D
-
A
-
L
-------------------
E
-
G
N
T
---
Q
G
---
V
--
T
Y
N
-
P
----
D
------------------------
H
-
I
-------------
P
------
D
R
L
-
P
F
-
K
D
--
L
T
-
L
-------
G
G
F
Y
L
R
------
I
A
-------
Q
Q
--
L
---
P
--
I
Y
E
V
S
A
Q
F
T
K
P
V
C
L
I
H
G
T
D
D
T
-
V
V
S
P
-
N
A
S
K
K
Y
D
Q
I
Y
Q
--
N
S
T
L
H
L
I
E
G
A
D
H
C
F
S
D
-
S
Y
Q
K
----
N
A
V
N
L
T
T
D
F
L
Q
-----
46
HHSearch
67.79
22%
-94
- C1 -
1ZOI
-
?
A:
[3-276]
---------
Y
V
T
T
K
D
G
V
Q
I
F
Y
K
D
W
G
P
---
R
D
A
--
P
V
I
H
F
H
H
G
W
P
--
L
--
S
A
D
--
D
W
D
A
-
Q
L
L
F
F
L
A
H
G
Y
R
V
V
A
H
D
R
R
G
H
G
R
S
S
Q
V
W
-
D
G
H
D
M
D
H
Y
A
D
D
V
-
A
A
V
V
A
H
L
G
----
I
Q
G
A
V
H
V
G
H
S
T
G
G
G
E
V
V
R
Y
M
A
R
H
P
E
D---
K
V
A
K
A
V
L
-
I
A
A
-
V
P
P
L
M
-
V
Q
-
T
-
P
GNPG
G
-------------
L
P
K
S
V
F
---
D
G
---
F
Q
A
Q
V
A
-
S
----
N
R
A
----
Q
---------
F
Y
R
D
V
P
A
G
P
-
F
Y
G
Y---
N
----
R
-
P
G
V
E
A
S
E
G
I
I
G
N
W
-
W
R
Q
G
M
I
-
G
-----
S
A
K
A
H
Y
D
G
------
I
V
-------
A
F
S
-
Q
--
T
D
--
F
T
E
D
L
K
G
I
Q
Q
P
V
L
V
M
H
G
D
D
D
Q
-
I
V
P
Y
-
E
N
S
G
V
L
S
A
K
L
L
-
P
N
G
A
L
K
T
Y
K
G
Y
P
H
G
M
P
T
-
T
H
A
D
----
V
I
N
A
D
L
L
A
F
I
R
S
----
35
HHSearch
65.87
20%
-85
- C1 -
2XUA
-
?
A:
[7-264]
-----------
A
A
V
N
G
T
E
L
H
Y
R
I
D
G
E
-
R
H
G
N
A
--
P
W
I
V
L
S
N
S
L
G
--
T
--
D
L
S
--
M
W
A
P
-
Q
V
A
A
L
S
-
K
H
F
R
V
L
R
Y
D
T
R
G
H
G
H
S
E
A
P
K
-
G
P
Y
T
I
E
Q
L
T
G
D
V
-
L
G
L
M
D
T
L
K
----
I
A
R
A
N
F
C
G
L
S
M
G
G
L
T
G
V
A
L
A
A
R
H
A
D
----
R
I
E
R
V
A
L
-
C
N
T
-
A
A
R
I
G
-
S
P
-
E
-
V
----
W
-------------
V
P
-
R
A
V
---
K
A
R
T
E
G
M
H
A
L
A
-
D
----
A
V
-----
L
---------
P
-
R
W
F
T
A
D
Y
-
M
-
E
----
R
----
E
-
P
------
V
V
L
A
M
I
--
R
D
V
F
V
-
H
T
D
K
--
E
G
Y
A
S
N
C
E
------
A
I
-------
D
A
-----
A
D
--
L
R
P
E
A
P
G
I
K
V
P
A
L
V
I
S
G
T
H
D
L
-
A
A
T
P
-
A
Q
G
R
E
L
A
Q
A
I
A
--
G
A
R
Y
V
E
L
-
D
A
S
H
I
S
N
I
-
E
R
A
D
----
A
F
T
K
T
V
V
D
F
L
T
E
----
54
Fugue
65.10
17%
-91
- C1 -
3PF8
1
?
A:
[16-266]
N
L
Y
F
Q
G
M
A
T
I
T
L
E
R
D
G
L
Q
L
V
G
T
R
E
E
P
-
F
G
E
I
Y
--
D
M
A
I
I
F
H
G
F
T
AN
R
--
N
T
S
--
L
L
R
E
-
I
A
N
S
L
R
D
E
N
I
A
S
V
R
F
D
F
N
G
H
G
D
S
D
G
K
-
F
E
N
M
T
V
L
N
E
I
E
D
A
-
N
A
I
L
N
Y
V
K
T
D
P
H
V
R
N
I
Y
L
V
G
H
S
Q
G
G
V
V
A
S
M
L
A
G
L
Y
P
D
----
L
I
K
K
V
V
L
-
L
A
P
-
A
A
T
L
K
-
G
D
-
A
-
L
----
E
--------------------------------------------------------------------
G
----
N
----
T
-
Q
------
G
V
T
Y
N
P
-
D
H
I
P
D
R
-
L
P
F
K
---
D
L
T
L
G
G
F
------
Y
L
-------
R
I
A
Q
Q
--
L
P
--
I
Y
E
V
S
A
Q
F
T
K
P
V
C
L
I
H
G
T
D
D
T
-
V
V
S
P
-
N
A
S
K
K
Y
D
Q
I
Y
Q
N
--
S
T
L
H
L
I
E
G
A
D
H
C
-
F
S
-
D
-
S
Y
-
Q
K
-
N
A
V
N
L
T
T
D
F
L
Q
N
----
40
HHSearch
65.09
18%
-97
- C1 -
4FBL
2
?
A:
[50-280]
------------------------------
S
R
--
I
G
V
L
V
S
H
G
F
T
--
G
--
S
P
Q
--
S
M
R
F
-
L
A
E
G
F
A
R
A
G
Y
T
V
A
T
P
R
L
T
G
H
G
T
T
P
A
E
M
-
A
A
S
T
A
S
D
W
T
A
D
I
-
V
A
A
M
R
W
L
E
E
R
--
C
D
V
L
F
M
T
G
L
S
M
G
G
A
L
T
V
W
A
A
G
Q
F
P
E
----
R
F
A
G
I
M
P
-
I
N
A
-
A
L
R
M
E
-
S
P
-
D
--------------------
L
A
-
A
L
A
---
F
N
------
P
D
A
-
P
----
A
E
---------------
L
-
P
G
I
G
-
S
D
-
I
-
K
----
A
-------------
E
G
V
K
E
L
-
A
Y
-
P
V
T
--------
P
V
P
A
I
K
H
------
L
I
-------
T
I
--
G
--
A
V
--
A
E
M
L
L
P
R
V
K
C
P
A
L
I
I
Q
S
R
E
D
H
-
V
V
P
P
-
H
N
G
E
L
I
Y
N
G
I
G
S
T
E
K
E
L
L
W
L
E
N
S
Y
H
V
A
T
L
-
D
N
D
K
-
E
--
L
I
L
E
R
S
L
A
F
I
R
K
----
49
Fugue
64.88
19%
-111
- C1 -
1R1D
1
EST_GEOSE
A:
[6-247]
--------------
P
P
K
P
F
F
F
E
-------
A
G
E
--
R
A
V
L
L
L
H
G
F
T
--
G
--
N
S
A
--
D
V
-
R
M
L
G
R
F
L
E
S
K
G
Y
T
C
H
A
P
I
Y
K
G
H
G
V
P
-
P
E
E
L
V
H
T
G
P
D
D
W
W
Q
D
V
M
N
G
Y
Q
F
L
K
N
K
G
Y
E
--
K
I
A
V
A
G
L
S
L
G
G
V
F
S
L
K
L
G
Y
T
V
P
------
I
E
G
I
V
T
M
C
A
P
M
Y
I
K
S
E
-
E
T
M
Y
-
E
----
G
-------------
V
L
-
E
Y
A
---
R
E
---
Y
K
K
R
---------------------------
E
G
K
S
E
E
Q
-
I
-
E
----
Q
----
E
M
E
------
R
F
K
Q
T
P
M
K
T
----------------
L
K
A
------
L
Q
-------
E
L
--
I
--
A
D
--
V
R
A
H
L
D
L
V
Y
A
P
T
F
V
V
Q
A
R
H
D
E
M
I
N
P
--
D
S
A
N
I
I
Y
N
E
I
E
S
P
V
K
Q
I
K
W
Y
E
Q
S
G
H
V
I
T
L
-
D
-
Q
E
-
K
D
-
Q
L
H
E
D
I
Y
A
F
L
E
S
L
D
W-
45
HHSearch
62.43
15%
-92
- C1 -
3U1T
3
?
A:
[16-296]
-------------
V
E
G
A
T
I
A
Y
V
D
E
G
-----
S
G
--
Q
P
V
L
F
L
H
G
N
P
--
T
--
S
S
Y
--
L
W
R
N
-
I
I
P
Y
V
V
A
A
G
Y
R
A
V
A
P
D
L
I
G
M
G
D
S
A
K
P
D
-
I
E
Y
R
L
Q
D
H
V
A
Y
M
-
D
G
F
I
D
A
L
G
----
L
D
D
M
V
L
V
I
H
D
W
G
S
V
I
G
M
R
H
A
R
L
N
P
D
----
R
V
A
A
V
A
F
-
M
E
A
-
L
V
P
P
A
-
L
P
-
M
-
P
SYE-
A
-------------
M
G
-
P
Q
L
---
G
P
---
L
F
R
D
L
R
T
A
D
V
G
E
K
M
VLDGN
F
---------
F
V
E
T
I
L
P
E
M
G
V
-
V
RS--
L
----
S
-
E
------
A
E
M
A
A
Y
-
R
A
-
P
F
P
-
T
R
Q
S
R
L
P
T
L
Q
W
P
R
E
------
V
P
IGGEP
A
F
A
E
A
E
V
--
L
K
--
N
G
E
W
L
M
A
S
P
I
P
K
L
L
F
H
A
E
P
G
A
-
L
A
P
K
-
P
V
V
D
Y
L
S
E
N
V
P
--
N
L
E
V
R
F
V
G
A
G
T
H
F
L
Q
E
-
D
H
P
H
----
L
I
G
Q
G
I
A
D
W
L
R
R
N
---
47
HHSearch
61.72
18%
-85
- C1 -
1MTZ
-
PIP_THEAC
A:
[8-293]
---------
N
Y
A
K
V
N
G
I
Y
I
Y
Y
K
L
C
K
A
-
P
-
E
E
K
--
A
K
L
M
T
M
H
G
G
P
--
G
--
M
S
H
--
D
Y
L
L
-
S
L
R
D
M
T
K
E
G
I
T
V
L
F
Y
D
Q
F
G
C
G
R
S
E
E
P
D
Q
S
K
F
T
I
D
Y
G
V
E
E
A
-
E
A
L
R
S
K
L
F
---
G
N
E
K
V
F
L
M
G
S
S
Y
G
G
A
L
A
L
A
Y
A
V
K
Y
Q
D
----
H
L
K
G
L
I
V
-
S
G
G
-
L
S
S
V
P
-
L
T
-
V
-
K
----
E
-------------
M
N
-
R
L
I
D
E
L
P
A
---
K
Y
R
D
A
I
-
K
----
K
Y
-----
G
S
S
GSYEN
P
E
Y
-
Q
E
A
V
N
Y
F
-
Y
-
H
Q
HLL
R
SEDW
P
-
P
------
E
V
L
K
S
L
-
E
Y
A
E
R
R
N
V
Y
R
I
--
M
N
G
P
N
E
F
T
------
I
T
-------
G
T
--
I
KD
W
D
--
I
T
D
K
I
S
A
I
K
I
P
T
L
I
T
V
G
E
Y
D
E
-
V
T
P
--
N
V
A
R
V
I
H
E
K
I
A
--
G
S
E
L
H
V
F
R
D
C
S
H
L
T
M
W
-
E
D
R
E
----
G
Y
N
K
L
L
S
D
F
I
L
K
H
L
--
8
PsiBlast_PDB
61.66
26%
-81
- C1 -
1A88
-
PRXC_STRLI
A:
[9-263]
----------------
T
N
I
F
Y
K
D
W
G
P
R
D
G
L
P
-----
V
V
F
H
H
G
W
P
--
L
--
S
A
D
--
D
W
D
N
-
Q
M
L
F
F
L
S
H
G
Y
R
V
I
A
H
D
R
R
G
H
G
R
S
-
D
Q
P
S
T
G
H
D
M
D
T
Y
A
A
D
-----
V
A
A
L
T
E
A
L
D
L
R
G
A
V
H
I
G
H
S
T
G
G
G
E
V
A
R
Y
-
V
A
R
A
E
PGRV
A
K
A
V
L
V
S
-
A
V
P
-
P
V
M
V
K
-
S
D
-
T
-
N
----
P
DGLP
L
E
V
F
D
E
F
R
A
A
L
-
A
A
N
---
R
A
---
Q
F
Y
I
D
V
-
P
----
S
G
-----
P
---------------
F
Y
G
-
F
-
N
----
R
----
E
-
G
------
A
T
V
-----
S
Q
G
L
I
-
D
H
W
W
--
L
Q
G
M
M
G
A
A
N
A
H
Y
E
C
I
A
-------
A
F
--
S
--
E
T
D-
F
T
D
D
L
K
R
I
D
V
P
V
L
V
A
H
G
T
D
D
Q
-
V
V
P
Y
A
D
A
A
P
K
S
A
E
L
L
--
A
N
A
T
L
K
S
Y
E
G
L
P
H
G
M
L
S
T
H
-
P
E
--------------------