@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0185: (2016-04-20 )
MIGADVPRDSQRARVYAAEAFVRTLFDRVTAHGSPTVEFFGTQLTLPPEGRFGSVASVQRYVDDVLALPAVGQNWPTVSPVRVRARRAATAAHYENHGGTGTIAVPDRHTAGWAMRELVVLHEVAHHLCQVPPPHGPEFVATVCTLTELVMGPEVGHVFRVVYAQEGVR
Atome Classification :
(20 SA)
----------.---........10....-....-20......-.--.30-....-....40--.........50........60..---..--...-----------.70----....-----..-..80......-...90--------.........100....--------...---110.......120...-....130--.----.......140..-------.....150---------.....--....160.......-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------M---IGADVPRDS
Q
R
A
R
V
-
Y
A
A
E
-
A
F
V
R
T
L
F
D
-
R
--
V
TA-HGS
P
-
T
V
E
F
F---G
T
Q
LTLPPEGRFG
S
V
A
S
V
Q
R
Y
V
D
---
D
V
--
L
AL-----------PAV----GQNW-----PT-VS
P
-
V
R
V
R
A
R
-R
A
A
T---------AAHYENHGG
T
G
T
I
AVP--------DRH---TA
G
W
A
M
R
E
L
V
V
L
H
E
V
A
-
H
H
L
CQV---P----PPH
G
P
E
F
V
A
T
V
C
-------
T
L
T
E
L
V-----------MGPE
V
--
G
H
V
F
R
V
V
Y
AQEGVR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
88.73
23%
-83
- C2 -
4XGC
-
?
D:
[5-457]
-D
R
E
L
V
S
I
R
R
F
---
L
K
E
R
L
Q
R
D
Y
T
T
L
R
G
-
Y
A
K
E
R
S
N
V
R
L
L
L
Q
-
R
--
T
A
E
-
M
G
E
S
---------
N
S
L
L
L
L
G
P
R
G
S
-
G
K
T
T
L
I
N
S
V
L
A
---
D
L
--
L
P
N
-----------
K
S
F
----
G
E
N
---------
T
L
I
-
V
H
L
D
G
---------------------------------------
N
L
H
---
T
D
D
-----
R
V
A
L
K
S
I
T
-
V
Q
M
Q
L
E
---
N
----
A
A
D
G
K
V
F
G
S
F
A
E
-------
N
L
A
F
L
L
-----------
Q
C
L
K
S
--
K
---
S
V
I
F
I
L
E
E
F
D
L
F
C
A
HHNQ
T
L
L
Y
N
L
F
D
V
S
Q
S
AQ
A
P
I
C
V
L
G
V
T
CRLDVIELLE
K
R
V
K
S
R
FSHRQ
V
F
L
F
PSLRR
F
E
D
Y
V
D
L
C
R
D
L
L
S
L
P
T
G
N
S
L
L
L
A
A
E
K
I
Y
N
L
Q
N
IQSGALYFSRNHFDPGE
Y
G
F
S
P
R
L
R
D
A
W
N
K
Q
I
C
K
V
L
A
T
Q
Q
A
R
S
T
L
Q
A
L
H
D
F
DIS
E
A
Y
L
K
N
F
L
F
R
L
V
A
H
LRPQSPHIT
A
E
K
M
A
A
V
G
S
Q
F
E
GD
D
K
I
E
L
L
C
G
LS
V
L
E
L
C
L
I
I
A
I
K
H
H
S
Q
I
Y
DRDSFN
F
E
I
I
Y
A
R
F
S
K
F
A
K
V
STTMQAVER
S
I
V
L
K
A
F
E
H
L
R
I
A
EL
I
M
P
L
TKVQKEF
E
M
H
K
L
ALT
Y
S
Q
I
H
H
C
M
Q
R
YQALPT
E
V
A
Q
W
A
QSS
27
Fugue
82.62
16%
-75
- C3 -
4Q7O
8
?
A:
[4-136]
----------
M
KNN
I
F
L
N
L
N
K
K
S
I
N
N
N
H
-
F
V
I
S
-
I
F
F
E
T
I
Y
Q
-
F
--
E
T
---
K
D
T
-
L
L
E
C
F
---
K
N
---
I
T
T
T
G
H
F
G
V
I
G
A
Q
Y
E
K
I
D
-----------------------------------------
A
T
-
R
W
I
G
D
Y
-
E
E
V
N
---------
G
F
E
Y
I
D
K
A
P
S
I
Y
F
S
V
G
--------
D
D
F
---
N
P
----
E
E
L
I
I
P
I
N
L
A
-
Y
H
Y
F
N
I
---
A
I
S
D
F
L
I
A
H
P
E
Y
Q
K
K
C
K
-------
E
I
Q
K
T
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
76.50
16%
-64
- C3 -
1IC8
2
HNF1A_HUMAN
A:
[3-192]
-----------------
K
E
L
E
N
L
S
P
E
E
A
-
A
H
Q
K
-
A
V
V
E
T
L
L
Q
-
E
--
D
P
W
-
R
V
A
K
-
M
V
K
S
Y
---
L
Q
Q
H
N
I
P
-----------
Q
R
E
V
V
---
D
T
TG
L
N
Q
-----------
S
H
L
----
S
Q
H
L
-----
N
K
-
G
T
P
-
M
K
T
Q
K
R
-
A
A
L
Y
---------
T
W
Y
V
R
K
Q
R
E
V
A
Q
Q
F
T
H
--------
A
R
N
---
R
F
K
W
G
P
A
S
Q
Q
I
L
F
Q
A
Y
-
E
R
Q
-
K
N
---
P
----
S
K
E
E
R
E
T
L
V
E
E
C
-------
N
R
A
E
C
I
Q
R
GVSPSQAQG
L
G
S
N
L
VT
E
V
R
V
Y
N
W
F
A
N
R
R
K
E
EA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
69.87
20%
-74
- C1 -
2Y9W
1
?
C:
[9-150]
--------LD
L
---
P
G
T
R
I
L
N
G
A
N
W
A
N
N
-
S
A
T
S
-
G
-
T
L
I
I
F
D
-
Q
--
S
T
P
-----------------------
G
Q
D
A
D
R
W
L
I
H
N
Y
L
D
---
G
Y
--
K
I
F
-----------
N
M
G
----
S
N
N
W
-----
A
S
-
V
S
R
---------------------------
G
N
T
V
L
G
V
S
E
F
--------
D
G
Q
---
T
C
K
W
---
S
I
E
Y
S
G
N
G
E
-
E
F
W
I
R
V
---
P
----
R
E
G
G
G
G
A
V
W
T
I
K
PASSQGP
T
T
V
F
L
D
-----------
L
L
K
E
T
--
D
P
N
Q
R
I
K
F
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.34
32%
-39
- C4 -
3WI7
2
DHAA_AGRFC
A:
[57-133]
-------------------------------------
R
H
I
F
R
-
R
--
L
H
G
-
H
G
R
L
L
A
V
D
L
I
---
G
Y
G
Q
S
S
K
P
D
I
E
Y
-
T
L
E
N
Q
Q
R
Y
V
D
A
W
F
D
A
--
L
D
L
RN
V
T
L
V
L
Q
D
Y
G
A
A
F
----
G
L
N
W
-----
A
S
-
R
N
P
-
D
R
V
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.15
32%
-43
- C4 -
3WIB
1
DHAA_AGRFC
A:
[57-133]
-------------------------------------
R
H
I
F
R
-
R
--
L
H
G
-
H
G
R
L
L
A
V
D
L
I
---
G
Y
G
Q
S
S
K
P
D
I
E
Y
-
T
L
E
N
Q
Q
R
Y
V
D
A
W
F
D
A
--
L
D
L
RN
V
T
L
V
L
Q
D
W
G
A
A
F
----
G
L
N
W
-----
A
S
-
R
N
P
-
D
R
V
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.42
26%
-25
- C4 -
2MAS
2
IUNH_CRIFA
A:
[21-116]
------------------------------------------------
A
-
H
G
N
P
-
E
I
E
L
L
---
A
I
T
-
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
---
D
I
--
A
G
I
-----------
T
G
V
P
I
A
A
G
C
D
K
-----
P
L
-
V
--------
R
-
K
I
M
T
---------
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
AEFK
N
K
V
D
E
R
H
---
A
V
N
L
I
I
-
D
L
V
M
S
H
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
60.70
14%
-86
* C2 *
2IAF
1
?
A:
[7-151]
---------------------
S
S
H
T
V
G
P
M
L
A
A
N
-
A
F
L
Q
L
L
E
Q
-
K
NL
F
D
K
-
T
Q
R
V
-
K
V
E
L
Y
---
G
-
S
L
A
L
T
G
K
G
H
---------
G
T
D
---
K
A
--
I
L
N
-----------
G
L
E
----
N
K
A
P
-----
E
S
M
I
P
R
M
H
E
I
L
D
S
-
N
L
L
N
---------
L
------
A
G
K
K
E
I
P
F
H
--------
E
A
T
---
D
F
L
F
L
Q
K
E
L
L
P
K
H
S
N
G
M
R
F
S
A
F
D
---
G
----
N
A
N
--------
L
-------
L
I
E
Q
V
Y
-----------
Y
S
I
G
G
--
G
F
I
T
T
E
E
D
F
D
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
60.19
26%
-52
- C4 -
1MAS
-
IUNH_CRIFA
A:
[21-116]
------------------------------------------------
A
-
H
G
N
P
-
E
I
E
L
L
---
A
I
T
-
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
---
D
I
--
A
G
I
-----------
T
G
V
P
I
A
A
G
C
D
K
-----
P
L
-
V
--------
R
-
K
I
M
T
---------------
E
S
G
M
G
T
V
A
Y
P
AEFK
N
K
V
D
E
R
H
---
A
V
N
L
I
I
-
D
L
V
M
S
H
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
58.79
22%
-82
- C4 -
4JIU
2
?
A:
[20-83]
--------------------------------------------------------------------------------------------------------------------------------
K
-
V
R
I
R
-
P
-
L
K
M
S
---------
I
A
R
V
S
F
K
--
Y
G
T
I
T
L
D
--------
P
A
V
L
--
N
L
E
E
E
E
M
F
Y
I
L
I
H
E
L
A
-
H
L
K
A
E
T
--------
S
Y
H
S
S
S
F
W
R
E
V
E
-------
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
53.56
9%
-46
* C3 *
2JRO
-
?
A:
[1-74]
-------------------
M
R
V
F
P
V
Y
A
P
-
K
L
I
V
-
K
H
A
R
I
F
L
T
G
V
--
I
W
V
-
K
D
L
G
-
R
L
E
F
E
---
K
G
R
F
L
L
P
R
K
S
L
P
K
V
K
Q
A
I
L
E
L
N
E
---
L
I
--
E
A
Q
-----------
N
H
Q
----
T
K
T
A
-----
L
E
-
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
52.34
15%
-65
- C4 -
4QHJ
4
Y1213_METJA
A:
[28-90]
--------------------------------------------------------------------------------------------------------------------------------
K
-
I
K
I
K
P
L
--
K
R
K
---------
I
A
S
I
S
L
T
--
N
K
T
I
Y
I
N
--------
K
N
I
LP-
Y
L
S
D
E
E
I
R
F
I
L
A
H
E
L
L
-
H
L
K
Y
G
---------
K
Y
H
I
N
E
F
E
E
E
L
L
-------
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
49.54
20%
-109
- C4 -
4JIX
7
Y123_METJA
A:
[47-94]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
T
L
R
L
N
--------
K
Y
V
V
E
-
N
F
D
E
E
L
L
H
Y
I
I
L
H
E
L
I
-
H
F
K
I
K
S
--------
I
N
H
G
I
K
F
E
N
E
L
R
-------
N
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
49.40
8%
-52
- C3 -
1ASH
2
GLB_ASCSU
A:
[1-147]
A
N
K
T
R
E
L
C
M
K
S
---
L
E
H
A
K
V
D
T
S
N
E
A
R
Q
-
D
G
I
D
-
L
Y
K
H
M
F
E
N
-
Y
--------
P
P
-
L
R
K
Y
F
---
K
S
R
E
E
Y
T
A
E
D
V
Q
N
D
P
F
F
A
K
Q
G
Q
K
---
I
L
--
L
A
C
-----------
H
V
L
----
C
A
T
Y
-----
D
D
-
R
E
T
-
F
N
A
Y
T
R
-
E
L
L
D
---------
R
H
A
R
D
H
-------------------
V
H
---
M
P
P
E
V
W
T
D
F
W
K
L
F
E
E
Y
-
L
G
K
K
T
T
---
L
----
D
E
P
T
K
Q
A
W
H
E
I
G
-------
R
E
F
A
K
E
-----------
I
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
39.65
15%
-6
- C3 -
3DTE
-
IRRE_DEIDV
A:
[8-100]
--------------------------------------------------------------------------
P
T
A
L
A
A
A
K
A
R
M
R
---
E
L
--
A
A
S
-----------
Y
G
A
----
G
L
-------
P
G
-
R
D
T
-
H
S
L
M
H
G
L
D
G
I
T
L
T
F
M
P
M
G
QR
D
G
A
Y
--
D
P
E
H
H
V
I
L
I
N
--------
S
Q
V
-----
R
P
E
R
Q
R
F
T
L
A
H
E
I
S
-
H
A
L
L
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
33.94
20%
-49
- C2 -
2E12
-
?
A:
[1-93]
--------------------
M
P
K
Y
A
P
H
V
-
Y
T
E
Q
-
A
Q
I
A
T
L
E
H
-
W
--
V
K
L
L
D
G
Q
E
-
R
V
R
I
E
L
DD
G
S
M
I
A
----
G
T
V
A
V
R
P
T
I
Q
T
Y
R
D
---
E
Q
--
E
R
E
-----------
G
S
N
----
G
Q
L
R
I
D
H
L
D
A
S
-
Q
E
P
-
Q
W
I
W
M
D
-
R
I
V
A
---------
V
H
P
M
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
31.19
26%
-31
- C4 -
3CQB
2
HTPX_VIBPA
A:
[65-98]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
V
A
V
S
--------
T
G
L
L
H
N
M
T
R
-
D
E
A
E
A
V
L
A
H
E
V
S
-
H
I
A
N
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
19.61
14%
8
- C4 -
1G12
1
A:
[110-141]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
A
G
T
L
V
H
E
S
S
-
H
F
T
R
N
G
GTK
D
----
Y
A
Y
G
Q
A
A
A
K
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
15.61
44%
40
- C4 -
3KHI
2
MTFA_KLEP7
A:
[145-160]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
L
V
V
H
E
V
A
-
H
K
L
D
T
R
---
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
15.49
38%
26
- C4 -
3MA2
1
MMP14_HUMAN
D:
[121-136]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
F
L
V
A
V
H
E
L
G
-
H
A
L
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------