@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0186: (2016-04-20 )
MTDDERFSLLVGLTGASDLWPVRDERIPQGVPMCAGYVPGIPRLGVPALLMSDAGLGVTNPGYRPGDTATALPAGLALAASFNPVLARSSGKAIGREARSRGFNVQLAGAINLARDPRNGRNFEYLSEDPLLSATMAAESIIGIQQQGVIATTKHFSLNCNETNRHWLDAVIDPDAHRESDLLAFEIVIERSQPGAVMAAYNKVNGDYAAGNDHLLNDVLKGAWGYRGWVMSDWGGTPSWECALAGLDQECGAQIDAVLWQSEAFTDRLRAAYADGNLPKGRLSDMVRRILRSMFAVGIDRWKPAPAPDMNAHNEIAAQMARQGIVLLQNRGLLPLAPESAGRIAVIGGYAHLGVPAGYGSSAVTPPGGYAGVIPIGGSGLAAGLRNLYLLPSSPLSELRKRLPNAQFEFDPGINPAEAVLAARRADIAIVFAIRAEGEGFDSADLSLPWGQDALIAAVASANANTVVVLETGNPVTMPWRDSVNAIMQAWYPGQAGGQAVAEIVTGQVNPSGRLPITFPVDLGQTPRSQPPELGAPWGTSTTIHYTEGADVGYRWFASTNQTPMFAFGHGLSYTSFEYRDLVVTGGHTVHASFSVTNTGDRSGADVPQLYMIAAPGESRLRLLGFERVELEPGQTRRVRIEADPRLLARYDGEARSWRIEPGGYTVAVGASAVALKLAAKVKLAGRGFGR
Atome Classification :
(20 SA)
--------------------------------.........10.......-----.20........30...-.....-------------40........50.......----.60...----....----.70........80........90........100.......110-.-......120.......130.......140.....------..150.......160....----------....170------------........180......-.190.......200.......210.......220...-....230..-..-.-..-----------240.-........250....-.----...----260...-....270.-......280.......290..-.------....300--------.------------.-.--------.---------------------------.-----...----------------------------310-------.......320.......330........340.......350...----------------.---------...360--------------........-.---370.......-..-380----.--.---....---------------------------------------------------------------------------------------------------.--.------------------------390------.---......----------..-------------------------400.--..--------.----.--.--------------.--410---.-------------.-----.------------.....420.......430..---.--------.--------.--------..440-------.----..----.--------....450-.......460--.----...----.....470....-..-.-480-.---.--.......490.......500.......510.......520.......530..--------....--.540.......550--........560.......570.......--580--------------...----------------------------------------------------------------------------------..--------------------------------------------------------------------------------------------.----.590........600........610-.---...--.-.-----.620---........630........640....-...650.......660.......670.......680.......690
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------MTDD
E
R
F
S
L
L
V
GLTGASD-----LWPVRDERIPQGVPMC-AGYVP-------------GIPRLG
V
P
A
L
L
MSDAGLGV----TNPGYR----PGDT----ATALPA
G
L
A
L
AASFN
P
V
L
ARSS
G
K
A
I
G
R
E
A
RSRGF
N
V
Q
L
A
G
A
I
N-L-ARDPRNGRNFEYLSEDPL
L
S
A
T
M
A
A
E
S
I
IGIQQQ------
G
V
I
A
T
T
K
H
F
S
L
NCN-ETN
R
----------
H
W
L
D
AV-------------IDPDAHRESD
L
L
A
F
E
I
V
-
I
ERSQPG
A
V
M
A
A
Y
NKVNGDYAAGN
D
H
L
L
N
D
V
L
K
GAWG-YRG
W
V
MSDW-GG-T-P
S
-----------
W
--
E
-
C
A
LAGL
D
Q
E
C-GAQ
I
-
D
----
A
V
L
----WQS
E
A
F
-
T
D
R
L
R
A
A
Y-ADGNLP
K
G
R
L
S
D
M
V
R
R
I
L
R
S
M
-
F
------
A
VGIDR---------W------------K-P--------A---------------------------P-----APD----------------------------MN
A
-------
H
N
E
I
A
A
Q
M
A
RQ
G
I
V
L
LQNR-GLLPLAPESA
G
R
I
A
V
I
GGY
A
H
LGV----------------P---------AGYG----------------SSAVTPPG-G---
Y
--
A
G
V
I
P
IG-
G
S
-
G
L
-----
A
--
A
---
G
L
R
N
---------------------------------------------------------------------------------------------------
L
--
Y
------------------------L--------L---PS
S
P
L
S
----------
E
L
-------------------------
R
K
RL--PN--------A----
Q
--
F
--------------
E
--FD----P-------------G-----I------------
N
P
A
E
A
V
L
A
ARRA
D
I
A
I
V
F
A
I
---
R
--------A--------E--------GEGF--------D----SA----D--------LSLPWG
Q
-
D
A
L
I
A
A
V
A----S----ANA----
N
T
V
V
V
L
ETGNPV-TM-P-
W
---
R
---
D
--
S
V
N
A
I
M
Q
AWYPGQAG
G
Q
A
V
A
E
I
V
TGQVNPSGR
L
P
I
T
F
PVDLGQTPRSQPPEL--------GAPW--GT
S
T
T
I
H
Y
TEGAD---V
G
Y
R
W
FASTNQT
P
M
F
A
FGHGLSYT
S
F
E
Y
--
R
D
L
--------------
V
V
T----------------------------------------------------------------------------------GG--------------------------------------------------------------------------------------------
H
----
T
V
-
H
A
S
F
S
V
TNTGD-RSGADV
P
Q
L
Y
M
-
I
---AAP--G-E-----S
R
-
L
---
R
L
L
G
F
E
R
V
E-LEPGQ
T
R
R
V
R
IEADP
R
-
L
L
A
R
YDGEA
R
S
W
R
IEPG
G
Y
T
V
A
VGA
S
A
V
A
L
K
L
A
A
K
V
K
LAGRGFGR-
52
Fugue
92.31
34%
-71
- C1 -
4IIB
17
BGL1_ASPAC
A:
[3-841]
L
A
F
S
P
P
F
Y
PS
P
W
A
N
GQGEW
A
E
A
Y
Q
R
A
V
A
I
V
S
Q
M
T
L
D
E
K
V
N
L
T
T
G
-
T
G
---------
W
---------
E
L
E
K
C
-
V
G
Q
T
G
-------------
G
V
P
R
L
N
I
G
G
M
C
L
Q
D
S
P
L
G
I
----
R
D
S
D
Y
N
-------------
S
A
F
P
A
G
V
N
V
A
A
T
W
D
K
N
L
A
Y
L
R
G
Q
A
M
G
Q
E
F
S
D
K
G
I
D
V
Q
L
G
P
A
A
G
P
L
-
G
R
S
P
D
G
G
R
N
W
E
G
F
S
P
D
P
A
L
T
G
V
L
F
A
E
T
I
K
G
I
Q
D
A
------
G
V
V
A
T
A
K
H
Y
I
L
N
E
Q
-
E
H
F
R
----------
Q
V
A
E
A
A
G
Y
GFNISD
T
I
S
S
N
V
D
D
K
T
I
H
E
M
Y
L
W
P
F
A
D
A
-
V
R
A
G
-
V
G
A
I
M
C
S
Y
N
Q
I
N
N
S
Y
G
C
Q
N
S
Y
T
L
N
K
L
L
K
A
E
L
G
-
F
Q
G
F
V
M
S
D
W
-
G
A
-
H
-
H
S
G----------
V
--
G
-
S
A
L
A
G
L
D
M
---
S
M
P
G
-
D
----
I
T
F
----
D
S
A
T
S
F
W
G
T
N
L
T
I
A
V
-
L
N
G
T
V
P
Q
W
R
V
D
D
M
A
V
R
I
M
A
A
Y
-
Y
------
K
V
G
R
D
R
---------
L
------------
Y
-
Q
--------
P
---------------------------
P
-----
N
F
S
SWTRDEYGFKYFYPQEGPYEKVNHFVNV
Q
R
N
-------
H
S
E
V
I
R
K
L
G
A
D
S
T
V
L
L
K
N
N
-
N
A
L
P
L
-
T
G
K
E
R
K
V
A
I
L
G
E
D
A
G
-------------------
S
---------
N
S
Y
G
----------------
A
N
G
C
S
D
R
G
-
C
---
D
--
N
G
T
L
A
M
A
W
G
S
-
G
------
T
--
A
---
E
F
P
Y
---------------------------------------------------------------------------------------------------
L
--
V
------------------------
T
--------
P
---
E
Q
A
I
Q
A
----------
E
V
-------------------------
L
K
H
K
--
G
S
--------
V
----
Y
--
A
--------------
I
--
T
D
----
N
-------------
W
------------------
A
L
S
Q
V
E
T
L
A
K
Q
A
S
V
S
L
V
F
V
N
---
S
--------
D
--------
A
--------
G
E
G
Y
--------
I
----
S
V
----
D
GNEGDRNN
L
T
L
W
K
N
G
-
D
N
L
I
K
A
A
A
----
N
----
N
C
N
----
N
T
I
V
V
I
H
S
V
G
P
V
-
L
V
-
D
E
W
---
Y
---
D
HP
N
V
T
A
I
L
W
A
G
L
P
G
Q
E
S
G
N
S
L
A
D
V
L
Y
G
R
V
N
P
G
A
K
S
P
F
T
W
G
K
T
R
E
A
Y
G
D
Y
L
V
R
E
L
--------
N
N
G
N
--
G
-
A
P
Q
D
D
F
S
E
G
V
F
---
I
D
Y
R
G
F
D
K
R
N
E
T
P
I
Y
E
F
G
H
G
L
S
Y
T
T
F
N
Y
--
S
G
L
--------------
H
I
Q
V
L
NAVATETG
A
A
P
T
F
G
Q
V
G
N
ASDYVYPEG
L
T
R
I
S
KFIYPWLNSTD
L
K
A
S
S
GDPYYGVDTAEHVPEGATDG
S
P
Q
P
V
L
PAGGGS
G
G
NPRLYD--------------------------------------------------------------------------------------
E
----
L
I
-
R
V
S
V
T
V
K
N
T
G
R
-
V
A
G
D
A
V
P
Q
L
Y
V
S
L
---
G
G
P
--
N
-
E
-----
P
K
-
V
---
V
L
R
K
F
D
R
L
T
-
L
K
P
S
E
E
T
V
W
T
T
T
L
T
R
R
-
D
L
S
N
W
D
V
A
A
Q
D
W
V
I
T
S
Y
P
K
K
V
H
V
G
S
S
S
R
Q
L
P
L
H
A
A
L
P
K
V
Q
------
3
PsiBlast_PDB
91.41
34%
-70
- C1 -
2X42
5
?
A:
[11-707]
--------------------------------
L
T
L
E
E
K
V
K
L
V
V
G
V
-
G
L
P
G
-----
L
F
G
N
P
H
S
R
----
V
A
G
A
-
A
G
E
T
H
-------------
P
V
P
R
V
G
L
P
A
F
V
L
A
D
G
P
A
G
L
----
R
I
N
P
T
R
----
E
N
D
E
N
T
Y
Y
T
T
A
F
P
V
E
I
M
L
A
S
T
W
N
R
E
L
L
E
E
V
G
K
A
M
G
E
E
V
R
E
Y
G
V
D
V
L
L
A
P
A
M
N
-
I
-
H
R
N
P
L
C
G
R
N
F
E
Y
Y
S
E
D
P
V
L
S
G
E
M
A
S
S
F
V
K
G
V
Q
S
Q
------
G
V
G
A
C
I
K
H
F
V
A
N
N
Q
-
E
T
N
R
----------
M
V
V
D
T
I
-------------
V
S
E
R
A
L
R
E
I
Y
L
R
G
F
E
I
A
-
V
K
K
S
K
P
W
S
V
M
S
A
Y
N
K
L
N
G
K
Y
C
S
Q
N
E
W
L
L
K
K
V
L
R
E
E
W
G
-
F
E
G
F
V
M
S
A
W
Y
A
G
-
D
-
N
P
-----------
V
--
E
-
Q
L
K
A
G
N
D
L
I
M
-
P
G
K
A
-
Y
----
Q
V
N
----
T
E
R
R
D
E
-
I
E
E
I
M
E
A
L
-
K
E
G
K
L
S
E
E
V
L
D
E
C
V
R
N
I
L
K
V
L
-
V
N-----
A
P
S
F
K
N
---------
Y
------------
R
-
Y
--------
S
---------------------------
N
-----
K
P
D
----------------------------
L
E
K
-------
H
A
K
V
A
Y
E
A
G
A
E
G
V
V
L
L
R
N
E
-
E
A
L
P
L
S
E
N
S
--
K
I
A
L
F
G
T
G
Q
I
E
T
I
----------------
K
---------
G
G
T
G
----------------
S
G
D
T
H
P
R
Y
-
A
---
I
--
S
I
L
E
G
I
K
-
E
R
-
G
L
NFD
E
E
L
--
A
---
K
T
Y
E
---------------------------------------------------------------------------------------------------
D
--
Y
------------------------
I
--------
K
---
K
M
R
E
T
E
----------
E
Y
-------------------------
K
P
R
R
-----------------------------------
I
--
I
K
----
P
-------------
K
LPENF
L
------------
S
E
K
E
I
H
K
L
A
K
K
N
D
V
A
V
I
V
I
S
---
R
--------
I
--------
S
--------
G
E
G
Y
--------
D
R
K
PV
K
G
----
D
--------
F
Y
L
S
D
D
E
-
T
D
L
I
K
T
V
S
R
E
F
H
E
----
Q
G
K
----
K
V
I
V
L
L
N
I
G
S
P
V
E
V
V
-
S
-
W
---
R
---
D
--
L
V
D
G
I
L
L
V
W
Q
A
G
Q
E
T
G
R
I
V
A
D
V
L
T
G
R
I
N
P
S
G
K
L
P
T
T
F
P
R
D
Y
S
D
V
P
S
W
T
F
P
----------
G
E
P
K
--
D
N
P
Q
K
V
V
Y
E
E
D
I
Y
---
V
G
Y
R
Y
Y
D
T
F
G
V
E
P
A
Y
E
F
G
Y
G
L
S
Y
T
T
F
E
Y
--
S
D
L
--------------
N
V
S
F
---------------------------------------------------------------------------------
D
G
--------------------------------------------------------------------------------------------
E
----
T
L
-
R
V
Q
Y
R
I
E
N
T
G
G
-
R
A
G
K
E
V
S
Q
V
Y
I
-
K
---
A
P
K
--
G
-
K
I
D
K
P
F
Q
E
-
L
---
K
A
F
H
K
T
R
L
--
L
N
P
G
E
S
E
E
V
V
L
E
I
P
V
R
-
D
L
A
S
F
N
G
E
--
E
W
V
V
E
A
G
E
Y
E
V
R
V
G
A
S
S
R
N
I
K
L
--------------
1
PsiBlast_PDB
91.19
34%
-71
- C1 -
2X40
5
?
A:
[11-707]
--------------------------------
L
T
L
E
E
K
V
K
L
V
V
G
V
-
G
L
P
G
-----
L
F
G
N
P
H
S
R
----
V
A
G
A
-
A
G
E
T
H
-------------
P
V
P
R
V
G
L
P
A
F
V
L
A
D
G
P
A
G
L
----
R
I
N
P
T
R
----
E
N
D
E
N
T
Y
Y
T
T
A
F
P
V
E
I
M
L
A
S
T
W
N
R
E
L
L
E
E
V
G
K
A
M
G
E
E
V
R
E
Y
G
V
D
V
L
L
A
P
A
M
N
-
I
-
H
R
N
P
L
C
G
R
N
F
E
Y
Y
S
E
D
P
V
L
S
G
E
M
A
S
S
F
V
K
G
V
Q
S
Q
------
G
V
G
A
C
I
K
H
F
V
A
N
N
Q
-
E
T
N
R
----------
M
V
V
D
T
I
-------------
V
S
E
R
A
L
R
E
I
Y
L
R
G
F
E
I
A
-
V
K
K
S
K
P
W
S
V
M
S
A
Y
N
K
L
N
G
K
Y
C
S
Q
N
E
W
L
L
K
K
V
L
R
E
E
W
G
-
F
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G
F
V
M
S
D
W
Y
A
G
-
D
-
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P
-----------
V
--
E
-
Q
L
K
A
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N
D
L
I
M
-
P
G
K
A
-
Y
----
Q
V
N
----
T
E
R
R
D
E
-
I
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I
M
E
A
L
-
K
E
G
K
L
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E
E
V
L
D
E
C
V
R
N
I
L
K
V
L
-
V
N-----
A
P
S
F
K
N
---------
Y
------------
R
-
Y
--------
S
---------------------------
N
-----
K
P
D
----------------------------
L
E
K
-------
H
A
K
V
A
Y
E
A
G
A
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G
V
V
L
L
R
N
E
-
E
A
L
P
L
S
E
N
S
--
K
I
A
L
F
G
T
G
Q
I
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T
I
----------------
K
---------
G
G
T
G
----------------
S
G
D
T
H
P
R
Y
-
A
---
I
--
S
I
L
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G
I
K
-
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R
-
G
L
NFD
E
E
L
--
A
---
K
T
Y
E
---------------------------------------------------------------------------------------------------
D
--
Y
------------------------
I
--------
K
---
K
M
R
E
T
E
----------
E
Y
-------------------------
K
P
R
---------------------------------------
I
K
----
P
-------------
K
LPENF
L
------------
S
E
K
E
I
H
K
L
A
K
K
N
D
V
A
V
I
V
I
S
---
R
--------
I
--------
S
--------
G
E
G
Y
--------
D
R
K
PV
K
G
----
D
--------
F
Y
L
S
D
D
E
-
T
D
L
I
K
T
V
S
R
E
F
H
E
----
Q
G
K
----
K
V
I
V
L
L
N
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S
P
V
E
V
V
-
S
-
W
---
R
---
D
--
L
V
D
G
I
L
L
V
W
Q
A
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Q
E
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G
R
I
V
A
D
V
L
T
G
R
I
N
P
S
G
K
L
P
T
T
F
P
R
D
Y
S
D
V
P
S
W
T
F
P
----------
G
E
P
K
--
D
N
P
Q
K
V
V
Y
E
E
D
I
Y
---
V
G
Y
R
Y
Y
D
T
F
G
V
E
P
A
Y
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F
G
Y
G
L
S
Y
T
T
F
E
Y
--
S
D
L
--------------
N
V
S
F
---------------------------------------------------------------------------------
D
G
--------------------------------------------------------------------------------------------
E
----
T
L
-
R
V
Q
Y
R
I
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N
T
G
G
-
R
A
G
K
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V
S
Q
V
Y
I
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K
---
A
P
K
--
G
-
K
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K
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F
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L
---
K
A
F
H
K
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R
L
--
L
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P
G
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V
L
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R
-
D
L
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--
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W
V
V
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A
G
E
Y
E
V
R
V
G
A
S
S
R
N
I
K
L
--------------
2
PsiBlast_PDB
91.15
34%
-70
- C1 -
2X41
5
?
A:
[11-707]
--------------------------------
L
T
L
E
E
K
V
K
L
V
V
G
V
-
G
L
P
G
-----
L
F
G
N
P
H
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R
----
V
A
G
A
-
A
G
E
T
H
-------------
P
V
P
R
V
G
L
P
A
F
V
L
A
D
G
P
A
G
L
----
R
I
N
P
T
R
----
E
N
D
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NTY
Y
T
T
A
F
P
V
E
I
M
L
A
S
T
W
N
R
E
L
L
E
E
V
G
K
A
M
G
E
E
V
R
E
Y
G
V
D
V
L
L
A
P
A
M
N
-
I
-
H
R
N
P
L
C
G
R
N
F
E
Y
Y
S
E
D
P
V
L
S
G
E
M
A
S
S
F
V
K
G
V
Q
S
Q
------
G
V
G
A
C
I
K
H
F
V
A
N
N
Q
-
E
T
N
R
----------
M
V
V
D
T
I
-------------
V
S
E
R
A
L
R
E
I
Y
L
R
G
F
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I
A
-
V
K
K
S
K
P
W
S
V
M
S
A
Y
N
K
L
N
G
K
Y
C
S
Q
N
E
W
L
L
K
K
V
L
R
E
E
W
G
-
F
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G
F
V
M
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W
Y
A
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-
D
-
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P
-----------
V
--
E
-
Q
L
K
A
G
N
D
L
I
M
-
P
G
K
A
-
Y
----
Q
V
N
----
T
E
R
R
D
E
-
I
E
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I
M
E
A
L
-
K
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G
K
L
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V
L
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V
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N
I
L
K
V
L
-
V
N-----
A
P
S
F
K
N
---------
Y
------------
R
-
Y
--------
S
---------------------------
N
-----
K
P
D
----------------------------
L
E
K
-------
H
A
K
V
A
Y
E
A
G
A
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G
V
V
L
L
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-
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L
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S
--
K
I
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L
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G
Q
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I
----------------
K
---------
G
G
T
G
----------------
S
G
D
T
H
P
R
Y
-
A
---
I
--
S
I
L
E
G
I
K
-
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R
-
G
L
NFD
E
E
L
--
A
---
K
T
Y
E
---------------------------------------------------------------------------------------------------
D
--
Y
------------------------
I
--------
K
---
K
M
R
E
T
E
----------
E
Y
-------------------------
K
P
R
R
-----------------------------------
I
--
I
K
----
P
-------------
K
LPENF
L
------------
S
E
K
E
I
H
K
L
A
K
K
N
D
V
A
V
I
V
I
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---
R
--------
I
--------
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--------
G
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Y
--------
D
R
K
PV
K
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----
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--------
F
Y
L
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D
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-
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R
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----
Q
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----
K
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L
L
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V
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V
V
-
S
-
W
---
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---
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--
L
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D
G
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L
L
V
W
Q
A
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Q
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T
G
R
I
V
A
D
V
L
T
G
R
I
N
P
S
G
K
L
P
T
T
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P
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D
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S
D
V
P
S
W
T
F
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----------
G
E
P
K
--
D
N
P
Q
K
V
V
Y
E
E
D
I
Y
---
V
G
Y
R
Y
Y
D
T
F
G
V
E
P
A
Y
E
F
G
Y
G
L
S
Y
T
T
F
E
Y
--
S
D
L
--------------
N
V
S
F
---------------------------------------------------------------------------------
D
G
--------------------------------------------------------------------------------------------
E
----
T
L
-
R
V
Q
Y
R
I
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N
T
G
G
-
R
A
G
K
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V
S
Q
V
Y
I
-
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---
A
P
K
--
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-
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I
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K
P
F
Q
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-
L
---
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A
F
H
K
T
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L
--
L
N
P
G
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V
V
L
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R
-
D
L
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F
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--
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W
V
V
E
A
G
E
Y
E
V
R
V
G
A
S
S
R
N
I
K
L
--------------
29
HHSearch
90.94
38%
-68
- C1 -
4I3G
12
?
A:
[61-828]
--------------------------------
M
T
L
D
E
K
I
S
F
V
H
W
A
----
L
------
D
P
------
D
R
---
Q
N
-
V
G
Y
L
P
-------------
G
V
P
R
L
G
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P
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A
A
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G
P
N
G
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----
R
L
V
--------
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Q
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D
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G
R
D
G
R
A
L
N
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M
V
L
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P
M
M
N
-
N
-
I
R
V
P
H
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G
R
N
Y
E
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F
S
E
D
P
L
V
S
S
R
T
A
V
A
Q
I
K
G
I
Q
G
A
------
G
L
M
T
T
A
K
H
F
A
A
N
N
Q
-
E
N
N
R
----------
F
S
V
N
A
N
-------------
V
D
E
Q
T
L
R
E
I
E
F
P
A
F
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A
S
-
S
K
-
A
G
A
A
S
F
M
C
A
Y
N
G
L
N
G
K
P
S
C
G
N
D
E
L
L
N
N
V
L
R
T
Q
W
G
-
F
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W
V
M
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W
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L
A
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T
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-----------
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--
D
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A
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L
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M
G
V
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L
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D
----
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GEPS
P
P
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F
F
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G
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L
L
----------
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A
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R
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-----
E
R
D
----------------------------
K
A
G
-------
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L
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L
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P
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D
P
K
----------------
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---------
T
G
L
G
----------------
S
A
H
V
V
P
D
S
-
A
A
--
A
P
L
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K
A
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A
-
G
A
G
A
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-----
V
--
T
Y
E
T
G
E
E
T
---------------------------------------------------------------------------------------------------
F
GT
Q
IPAGNLSPAFNQGHQLEPGKAGAL
Y
D
G
T
L
T
V
P
A
D
---
G
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Y
R
I
A
V
R
A
T
G
G
Y
A
T
V
Q
L
GS
H
T
I
E
A
------------------
G
Q
V
Y
--
G
K
V
S
S
P
L
L
K
L
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H
K
L
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G
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A
M
SAT
P
L
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L
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L
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--
W
V
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P
A
A
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-------------
D
-----
A
------------
T
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A
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A
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K
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A
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A
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V
F
A
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---
D
--------
D
--------
G
--------
T
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G
V
--------
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----
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P
----
N
--------
L
S
L
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K
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A
----
D
----
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----
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V
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A
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L
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P
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A
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D
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-
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--------
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Y
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---
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N
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Q
T
Y
R
E
G
I
H
---
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G
Y
R
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V
K
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L
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F
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H
G
L
S
Y
T
S
F
T
Q
--
S
A
P
--------------
T
V
V
----------------------------------------------------------------------------------
R
T
--------------------------------------------------------------------------------------------
S
T---
G
G
L
K
V
T
V
T
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L
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G
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S
A
D
L
R
G
S
A
T
V
N
V
--------
31
HHSearch
90.84
34%
-70
- C1 -
2X41
5
?
A:
[11-716]
--------------------------------
L
T
L
E
E
K
V
K
L
V
V
G
V
G
L
P
G
L
-----
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------
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N
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H
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A
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A
A
G
E
T
H
-------------
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V
P
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V
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L
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A
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L
A
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G
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A
G
L
----
R
I
N
P
T
R
ENDE
N
T
Y
Y
----
T
T
A
F
P
V
E
I
M
L
A
S
T
W
N
R
E
L
L
E
E
V
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K
A
M
G
E
E
V
R
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Y
G
V
D
V
L
L
A
P
A
M
N
-
I
-
H
R
N
P
L
C
G
R
N
F
E
Y
Y
S
E
D
P
V
L
S
G
E
M
A
S
S
F
V
K
G
V
Q
S
Q
------
G
V
G
A
C
I
K
H
F
V
A
N
N
Q
-
E
T
N
R
----------
M
V
V
D
T
I
-------------
V
S
E
R
A
L
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L
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F
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C
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N
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L
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V
L
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E
W
G
-
F
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G
F
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A
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N
-----------
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L
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------
N
A
P
S
F
----------
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------------
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-
Y
RY------
S
---------------------------
N
-----
K
P
D
----------------------------
L
E
K
-------
H
A
K
V
A
Y
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A
G
A
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V
V
L
L
R
N
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L
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N
--
S
K
I
A
L
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G
T
G
Q
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T
I
----------------
K
---------
G
G
T
G
----------------
S
G
D
T
H
P
R
Y
-
A
I
--
S
I
L
E
G
I
K
E
R
G
-
L
N
-
F
D
-----
E
--
E
L
A
-
K
T
Y
E
---------------------------------------------------------------------------------------------------
D
--
Y
------------------------
I
--------
K
K
M
R
E
T
E
E
Y
K
----------
P
R
-------------------------
R
--------------------
I
--
I
--------------
K
PK
L
P
----
E
N------------
F
-----
L
------------
S
E
K
E
I
H
K
L
A
K
K
N
D
V
A
V
I
V
I
S
---
R
--------
I
--------
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--------
G
E
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Y
--------
D
----
R
K
PVKG
D
--------
F
Y
L
S
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-
T
D
L
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----
R
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H
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L
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---
R
---
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--
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L
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G
----------
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--
D
N
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K
V
V
Y
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E
D
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Y
---
V
G
Y
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Y
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F
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Y
G
L
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Y
T
T
F
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Y
--
S
D
L
--------------
N
V
S
----------------------------------------------------------------------------------
F
D
--------------------------------------------------------------------------------------------
G
----
E
T
L
R
V
Q
Y
R
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N
T
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G
-
R
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V
S
Q
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---
A
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K
G-
K
I
D
-----
K
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F
Q
---
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L
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L
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-
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--
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V
G
A
S
S
R
N
I
K
L
K
G
T
F
S
V
G
E
E
-----
50
Fugue
89.97
34%
-67
- C1 -
2X41
5
?
A:
[2-721]
-----------------------E
K
V
N
E
I
L
S
Q
L
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L
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E
K
V
K
L
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-----
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-------------
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L
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----
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Y
----
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L
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Y
S
E
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P
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L
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G
E
M
A
S
S
F
V
K
G
V
Q
S
Q
------
G
V
G
A
C
I
K
H
F
V
A
N
N
Q
-
E
T
N
R
----------
M
V
V
D
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-------------
V
S
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L
R
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Y
L
R
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F
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--------
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---------------------------
N
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K
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----------------------------
L
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--
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K
---------
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G
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----------------
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--
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---
L
A
K
T
---------------------------------------------------------------------------------------------------
Y
--
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------------------------
D
--------
Y
---
I
K
K
M
R
E
----------
T
E
-------------------------
E
Y
K
P
RR
I
I
--------
K
----
P
--
K
--------------
L
--
P
E
----
N
-------------
F
-----
L
------------
S
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---
R
--------
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--------
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R
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----
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----
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----
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---
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---
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--
L
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D
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L
L
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L
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L
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D
V
P
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W
T
F
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----------
G
E
P
K
--
D
N
P
Q
K
V
V
Y
E
E
D
I
Y
---
V
G
Y
R
Y
Y
D
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G
V
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A
Y
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G
L
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Y
T
T
F
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Y
--
S
D
L
--------------
N
V
S
F
---------------------------------------------------------------------------------
D
G
--------------------------------------------------------------------------------------------
E
----
T
L
-
R
V
Q
Y
R
I
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N
T
G
G
-
R
A
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Y
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---
A
P
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--
G
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K
-----
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A
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L
K
G
T
F
S
V
G
E
E
R
R
F
K
P
30
HHSearch
88.78
32%
-69
- C1 -
3ABZ
4
?
A:
[13-840]
--------------------------------
L
N
Q
D
E
K
I
S
L
L
S
A
V
----
D
-----
F
W
-----------------
H
T
K
-------------
K
I
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L
G
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A
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----
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----
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G
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A
A
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L
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P
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G
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G
G
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G
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L
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M
A
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S
S
V
V
K
G
M
Q
G
E
------
G
I
A
A
T
V
K
H
F
V
C
N
D
L
-
E
D
Q
R
----------
F
S
S
N
S
I
-------------
V
S
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R
A
L
R
E
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Y
L
E
P
F
R
L
A
-
V
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C
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K
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G
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T
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T
-----------
T
A-
A
-
A
I
K
N
G
L
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F
P
G
P
T
R
-
W
---------------
R
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R
A
L
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H
S
L
N
S
R
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-------
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---------------------------
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----------------------------
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L
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K
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--
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N
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A
K
A
K
T
----------------
S
---------
S
G
G
G
----------------
S
A
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Y
Y
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V
--
S
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L
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V
-----
D
Y
T
V
---
G
A
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KSIGGLAESSLIDAAKPADAEN
S
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L
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A
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SNPVEERSDDEEPF
H
V
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V
NRSNVHLFDFKHEKVDPKNP
Y
F
F
V
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L
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G
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Y
V
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Y
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L
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--
Y
------------------------
L
--------
N
---
D
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L
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D
----------
Q
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Q
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K
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--------------
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----
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GPTSGLVGEFGA
G
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-----
F
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A
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R
N
A
A
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L
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--------
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L
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K
L
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L
S
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P
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K
L
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N
P
A
F
L
N
F
------------
K
---
T
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F
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R
V
I
Y
G
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D
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F
---
V
G
Y
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Y
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Y
T
T
F
E
L
D
I
S
D
F
--------------
K
V
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
D
K
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A
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D
D
I
L
S
V
K
E
F
K
V
E
K
E
L
----
33
HHSearch
88.69
32%
-71
- C1 -
4IIB
17
BGL1_ASPAC
A:
[35-838]
--------------------------------
M
T
L
D
E
K
V
N
L
T
T
G
T
----
G
-----
W
E
----------
L
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C
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V
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Q
T
G
-------------
G
V
P
R
L
N
I
G
G
M
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L
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D
S
P
L
G
I
----
R
D
S
---------
D
Y
----
N
S
A
F
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A
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V
N
V
A
A
T
W
D
K
N
L
A
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L
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G
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G
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N
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L
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G
V
L
F
A
E
T
I
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G
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A
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V
A
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A
K
H
Y
I
L
N
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N
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----------
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N
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L
L
K
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M
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G
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L
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A
V
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L
N
G
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Q
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R
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D
M
A
V
R
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M
A
A
Y
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------
K
V
G
R
D
----------
R
------------
L
-
Y
QP------
P
NFSSWTRDEYGFKYFYPQEGPYEKVNH
F
-----
V
N
V
----------------------------
Q
R
N
-------
H
S
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V
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L
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A
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A
G
S
N
S
----------------
Y
---------
G
A
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CSDRGCDNGTLA
M
A
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G
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G
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A
E
F
P
Y
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L
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--
T
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A
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L
K
--------------------------------------------------------------------------------------------------------------------------------------------------
H
--------
K
---
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S
--------------------------------------------------------------
V
--
Y
--------------
A
--
I
T
----
D
-------------
N
-----
W
------------
A
L
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S
L
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---
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--------
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--------
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----
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--------
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G
K
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R
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A
Y
G
D
Y
L
V
R
E
----------
L
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G-
N
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A
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D
D
F
S
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G
V
F
---
I
D
Y
R
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F
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K
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F
G
H
G
L
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Y
T
T
F
N
Y
--
S
G
L
--------------
H
I
Q
----------------------------------------------------------------------------------
V
L
NAVATETG
A
A
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G
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V
G
N
ASDYVYPEG
L
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L
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S
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Q
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V
L
PAGGGSGGNPRLY-----
D
----
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V
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V
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-
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---
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--
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-
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-----
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V
---
V
L
R
K
F
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W
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T
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L
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L
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K
V
H
V
G
S
S
S
R
Q
L
P
L
H
A
A
L
P
---------
34
HHSearch
88.04
35%
-65
- C1 -
4D0J
15
?
A:
[54-852]
--------------------------------
L
T
L
A
E
K
V
N
L
T
T
G
T
----
G
------
W
E
------
Q
---
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R
C
-
V
G
Q
V
G
-------------
S
I
P
R
L
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L
G
V
----
R
D
T
---------
D
Y
----
N
S
A
F
P
A
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V
N
V
A
A
T
W
D
R
N
L
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R
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M
G
E
E
H
R
G
K
G
V
D
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Q
L
G
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A
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-
G
R
S
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A
G
R
N
W
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A
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L
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N
M
M
A
S
T
I
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G
I
Q
D
A
------
G
V
I
A
C
A
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H
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L
Y
E
Q
-
E
H
F
R
QGAQDGY---
D
I
S
D
S
I
S
A
N
----------
A
D
D
K
T
M
H
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L
Y
L
W
P
F
A
D
A
-
V
R
-
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M
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-----------
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L
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----
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------
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----------
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------------
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-
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INFDSW
T
LDTYGPEHYAVGQGQTKINE-------
H
-----
V
D
V
----------------------------
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WGVNGCSDRGCDNGTL
A
---------
M
G
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----------------
S
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V--
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---------------------------------------------------------------------------------------------------------------------------------------------------------
N
---
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--------------
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--
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T
----
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-------------
N
-----
G
------------
A
L
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L
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N
---
A
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--------
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GEGYITVD
G
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G
--------
D
----
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K
----
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--------
L
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L
W
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A
-
D
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S
----
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----
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----
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Y
T
T
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F
--
S
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L
--------------
N
V
Q
----------------------------------------------------------------------------------
P
I
NAPPYTP
A
S
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T
KAAQSFGQPSNASDNLYPSDIERVPLYIYPWLNSTD
L
K
A
S
A
NDPDYGLPTEKYVPPNATNG
D
P
Q
P
I
DPAGGAPGGNPSLY
E
----
P
V
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T
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T
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K
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V
T
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V
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L
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---
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--
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-----
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---
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Y
V
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S
R
N
L
P
L
Q
A
P
L
K
---------
32
HHSearch
83.26
30%
-72
- C1 -
3ZYZ
6
?
A:
[23-712]
--------------------------------
L
N
L
Q
D
K
V
G
I
V
S
G
V
----
G
-----
W
N
G
G
-------
P
C
V
G
----
N
T
S
-------------
P
A
S
K
I
S
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P
S
L
C
--
L
Q
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G
P
L
----
G
V
R
-
Y
------
S
T
G
----
S
T
A
F
T
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G
V
Q
A
A
S
T
W
D
V
N
L
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E
R
G
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F
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P
V
A
G
-
P
L
G
K
T
P
Q
G
G
R
N
W
E
G
F
G
V
D
P
Y
L
T
G
I
A
M
G
Q
T
I
N
G
I
Q
S
V
------
G
V
Q
A
T
A
K
H
Y
I
L
N
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Q
-
E
L
N
R
----------
E
T
I
S
S
N
-------------
P
D
D
R
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L
Y
T
W
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A
-
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A
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HARNSPSCN-------
D
KGCDDGALG
M
G
W
G
----------------
S
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V
N
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V
---
A
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A
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-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---
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----
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--------------
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L
S
----
N
-------------
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-----
D
------------
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K
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A
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V
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T
---
A
D
S
GEGYIT
V
--------
E
--------
G
N
A
G
--------
D
----
R
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----
N
--------
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W
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G
-
N
A
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----
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----
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D
Y
N
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------------
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------
G
G
S
D
S
F
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L
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---
I
D
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Y
G
L
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Y
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K
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N
Y
--
S
R
L
--------------
S
V
L
----------------------------------------------------------------------------------
S
T
A
K
S
G
P
ATGAVVPGGPSDLF-------------------------------------------------------------------------
Q
----
N
V
A
T
V
T
V
D
I
A
N
S
G
Q
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V
T
G
A
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A
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S-
A
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R
-----
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D
I
R
L
T
S
T
L
S
V
--------
35
HHSearch
82.66
29%
-72
- C1 -
3U48
2
?
A:
[14-731]
--------------------------------
M
T
L
D
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K
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TTGQA
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L
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M
D
V
I
H
G
Y
----------------------
E
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L
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DFSDNT
S
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A
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Y
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A
G
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A
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----------
D
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N
T
V
D
-------------
M
S
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---------
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S
L
L
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R
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L
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---
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I
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A
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---
E
S
AE-----
M
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FQK
F
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N
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L
D
V
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P
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D
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G
L
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F
T
K
F
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Y
--
G
D
L
--------------
K
L
S
----------------------------------------------------------------------------------
S
T
--------------------------------------------------------------------------------------------
N
LKGN
Q
T
L
T
A
S
I
E
L
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G
D
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S
R
D
L
K
S
Q
-------------
4
PsiBlast_PDB
81.27
29%
-66
- C1 -
3ZYZ
6
?
A:
[42-713]
----------------------------------------------------------------------
C
-
V
G
N
T
S
-------------
P
A
S
K
I
S
Y
P
S
L
C
L
Q
D
G
P
L
G
V
---------
R
----
Y
S
T
G
----
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A
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T
P
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P
Y
L
T
G
I
A
M
G
Q
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N
G
I
Q
S
V
------
G
V
Q
A
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A
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H
Y
I
L
N
E
Q
-
E
L
N
R
----------
E
T
I
S
S
---------------
N
P
D
D
R
T
L
H
E
L
Y
T
W
P
F
A
D
A
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Q
A
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A
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M
C
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Y
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T
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L
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D
Q
L
G
-
F
P
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Y
V
M
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W
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N
A
-
Q
H
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T
-----------
V
--
Q
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S
A
N
S
G
L
D
M
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M
P
G
T
D
F
-
N
----
G
-------
N
N
R
L
W
-
G
P
A
L
T
N
A
V
-
N
S
N
Q
V
P
T
S
R
V
D
D
M
V
T
R
I
L
A
A
W
-
Y
------
L
T
G
Q
D
Q
---------------------------------
A
---------------------------
G
-----
Y
P
S
----------------------------
F
N
I
SRNVQGN
H
K
T
N
V
R
A
I
A
R
D
G
I
V
L
L
K
N
D
A
N
I
L
P
L
--
K
K
P
A
S
I
A
V
V
G
S
A
A
I
I
G
N
----------------
H
---------
A
-
R
N
----------------
S
P
S
C
N
D
K
G
-
C
---
D
--
D
G
A
L
----
G
M
-
G
W
-----
G
--
S
---
G
A
V
N
---------------------------------------------------------------------------------------------------
Y
P-
Y
------------------------
F
--------
V
---
A
P
Y
D
A
I
----------
N
T
-------------------------
R
A
S
S
--
Q
G
--------
T
----
Q
--
V
--------------
T
--
L
S
----
N
-------------
T
-----
D
------------
N
T
S
S
G
A
S
A
A
R
G
K
D
V
A
I
V
F
I
T
---
A
--------
D
--------
S
--------
G
E
G
Y
ITVEGNAG
D
----
R
N
----
N
--------
L
D
-
P
W
H
N
G
N
A
L
V
Q
A
V
A
----
G
----
A
N
S
----
N
V
I
V
V
V
H
S
V
G
A
I
-
I
L
-
E
-
Q
I
L
A
L
---
P
--
Q
V
K
A
V
V
W
A
G
L
P
S
Q
E
S
G
N
A
L
V
D
V
L
W
G
D
V
S
P
S
G
K
L
V
Y
T
I
A
--------
K
S
P
N
D
Y
--------
N
T
R
I
--
V
S
G
G
S
D
S
F
S
E
G
L
F
---
I
D
Y
K
H
F
D
D
A
N
I
T
P
R
Y
E
F
G
Y
G
L
S
Y
T
K
F
N
Y
--
S
R
L
S
V
L
S
T
A
K
S
G
P
ATGA
V
V
P
----------------------------------------------------------------------------------
G
G
PSDLFQ--------------------------------------------------------------------------------------
N
----
V
A
-
T
V
T
V
D
I
A
N
S
G
Q
-
V
T
G
A
E
V
A
Q
L
Y
I
-
T
Y
PS
S
A
P
--
R
-
T
-----
P
P
-
K
---
Q
L
R
G
F
A
K
L
N
-
L
T
P
G
Q
S
G
T
A
T
F
N
I
R
R
R
-
D
L
S
Y
W
D
T
A
S
Q
K
W
V
V
P
S
G
S
F
G
I
S
V
G
A
S
S
R
D
I
R
L
T
S
T
L
S
V
A
-------
9
PsiBlast_PDB
80.70
30%
-75
- C1 -
4IID
13
BGL1_ASPAC
A:
[35-650]
--------------------------------
M
T
L
D
E
K
V
N
L
T
T
G
-
T
G
---------
W
E
L
E
K
---------
C
-
V
G
Q
T
G
-------------
G
V
P
R
L
N
I
G
G
M
C
L
Q
D
S
P
L
G
I
---------
R
----
D
S
D
Y
----
N
S
A
F
P
A
G
V
N
V
A
A
T
W
D
K
N
L
A
Y
L
R
G
Q
A
M
G
Q
E
F
S
D
K
G
I
D
V
Q
L
G
P
A
A
G
P
L
-
G
R
S
P
D
G
G
R
N
W
E
G
F
S
P
D
P
A
L
T
G
V
L
F
A
E
T
I
K
G
I
Q
D
A
------
G
V
V
A
T
A
K
H
Y
I
L
N
E
Q
-
E
H
F
R
----------
Q
V
A
E
A
A
G
Y
GFNISD
T
I
S
S
N
V
D
D
K
T
I
H
E
M
Y
L
W
P
F
A
D
A
-
V
-
R
A
G
V
G
A
I
M
C
S
Y
N
Q
I
N
N
S
Y
G
C
Q
N
S
Y
T
L
N
K
L
L
K
A
E
L
G
-
F
Q
G
F
V
M
S
D
W
-
G
A
-
H
-
H
S
-----------
G
--
V
G
S
A
L
A
G
L
D
M
S
M
-
P
G
D
I
-
T
FDSA
T
S
F
----
W
G
T
------
N
L
T
I
A
V
-
L
N
G
T
V
P
Q
W
R
V
D
D
M
A
V
R
I
M
A
A
Y
-
Y
------
K
V
G
R
D
R
LYQPPNFSS
W
TRDEYGFKYFYP
Q
-
E
--------
G
---------------------------
P
-----
Y
E
K
----------------------------
V
N
H
FVNVQRN
H
S
E
V
I
R
K
L
G
A
D
S
T
V
L
L
K
N
N
-
N
A
L
P
L
T
G
K
E
R
-
K
V
A
I
L
G
E
D
A
G
-------------------
S
---------
N
S
Y
G
----------------
A
N
G
C
S
D
R
G
-
C
---
D
--
N
G
T
L
A
M
A
W
G
S
-
G
T
-----
A
--------
E
F
---------------------------------------------------------------------------------------------------
P
--
Y
------------------------
L
--------
V
T
--
P
E
Q
A
I
Q
----------
A
E
-------------------------
V
L
K
H
--
K
G
--------
S
----
V
--
Y
--------------
A
--
I
T
----
D
-------------
N
-----
W
------------
A
L
S
Q
V
E
T
L
A
K
Q
A
S
V
S
L
V
F
V
N
---
S
--------
D
--------
A
--------
G
E
G
Y
--------
I
----
S
V
----
D
GNEGDRNN
L
T
L
W
K
N
G
-
D
N
L
I
K
A
A
A
----
N
----
N
C
N
----
N
T
I
V
V
I
H
S
V
G
P
V
-
L
V
D
E
-
W
---
Y
---
D
HP
N
V
T
A
I
L
W
A
G
L
P
G
Q
E
S
G
N
S
L
A
D
V
L
Y
G
R
V
N
P
G
A
K
S
P
F
T
W
----
G
K
T
R
E
A
Y
G
D
Y
L
VRELNNGN
G
A
P
-------
Q
D
D
F
S
E
G
V
F
---
I
D
Y
R
G
F
D
K
R
N
E
T
P
I
Y
E
F
G
H
G
L
S
Y
T
T
F
N
Y
--
S
G
L
--------------
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.28
29%
-65
- C1 -
3ZZ1
2
?
A:
[42-713]
----------------------------------------------------------------------
C
-
V
G
N
T
S
-------------
P
A
S
K
I
S
Y
P
S
L
C
L
Q
D
G
P
L
G
V
---------
R
----
Y
S
T
G
----
S
T
A
F
T
P
G
V
Q
A
A
S
T
W
D
V
N
L
I
R
E
R
G
Q
F
I
G
E
E
V
K
A
S
G
I
H
V
I
L
G
P
V
A
G
P
L
-
G
K
T
P
Q
G
G
R
N
W
E
G
F
G
V
D
P
Y
L
T
G
I
A
M
G
Q
T
I
N
G
I
Q
S
V
------
G
V
Q
A
T
A
K
H
Y
I
L
N
E
Q
-
E
L
N
R
----------
E
T
I
S
S
---------------
N
P
D
D
R
T
L
H
E
L
Y
T
W
P
F
A
D
A
V
Q
A
N
V
A
S
V
M
C
S
Y
N
K
V
N
T
T
W
A
C
E
D
Q
Y
T
L
Q
T
V
L
K
D
Q
L
G
-
F
P
G
Y
V
M
T
D
W
-
N
A
-
Q
H
T
T
-----------
V
--
Q
-
S
A
N
S
G
L
D
M
S
M
P
G
T
D
F
-
N
----
G
-------
N
N
R
L
W
-
G
P
A
L
T
N
A
V
-
N
S
N
Q
V
P
T
S
R
V
D
D
M
V
T
R
I
L
A
A
W
-
Y
------
L
T
G
Q
D
Q
---------------------------------
A
---------------------------
G
-----
Y
P
S
----------------------------
F
N
I
SRNVQGN
H
K
T
N
V
R
A
I
A
R
D
G
I
V
L
L
K
N
D
A
N
I
L
P
L
--
K
K
P
A
S
I
A
V
V
G
S
A
A
I
I
G
N
----------------
H
---------
A
-
R
N
----------------
S
P
S
C
N
D
K
G
-
C
---
D
--
D
G
A
L
----
G
M
-
G
W
-----
G
--
S
---
G
A
V
N
---------------------------------------------------------------------------------------------------
Y
P-
Y
------------------------
F
--------
V
---
A
P
Y
D
A
I
----------
N
T
-------------------------
R
A
S
S
--
Q
G
--------
T
----
Q
--
V
--------------
T
--
L
S
----
N
-------------
T
-----
D
------------
N
T
S
S
G
A
S
A
A
R
G
K
D
V
A
I
V
F
I
T
---
A
--------
D
--------
S
--------
G
E
G
Y
ITVEGNAG
D
----
R
N
----
N
--------
L
D
-
P
W
H
N
G
N
A
L
V
Q
A
V
A
----
G
----
A
N
S
----
N
V
I
V
V
V
H
S
V
G
A
I
-
I
L
-
E
-
Q
I
L
A
L
---
P
--
Q
V
K
A
V
V
W
A
G
L
P
S
Q
E
S
G
N
A
L
V
D
V
L
W
G
D
V
S
P
S
G
K
L
V
Y
T
I
A
--------
K
S
P
N
D
Y
--------
N
T
R
I
--
V
S
G
G
S
D
S
F
S
E
G
L
F
---
I
D
Y
K
H
F
D
D
A
N
I
T
P
R
Y
E
F
G
Y
G
L
S
Y
T
K
F
N
Y
--
S
R
L
S
V
L
S
T
A
K
S
G
P
ATGA
V
V
P
----------------------------------------------------------------------------------
G
G
PSDLFQ--------------------------------------------------------------------------------------
N
----
V
A
-
T
V
T
V
D
I
A
N
S
G
Q
-
V
T
G
A
E
V
A
Q
L
Y
I
-
T
Y
PS
S
A
P
--
R
-
T
-----
P
P
-
K
---
Q
L
R
G
F
A
K
L
N
-
L
T
P
G
Q
S
G
T
A
T
F
N
I
R
R
R
-
D
L
S
Y
W
D
T
A
S
Q
K
W
V
V
P
S
G
S
F
G
I
S
V
G
A
S
S
R
D
I
R
L
T
S
T
L
S
V
A
-------
10
PsiBlast_PDB
80.26
30%
-75
- C1 -
4IIE
15
BGL1_ASPAC
A:
[35-650]
--------------------------------
M
T
L
D
E
K
V
N
L
T
T
G
-
T
G
---------
W
E
L
E
K
---------
C
-
V
G
Q
T
G
-------------
G
V
P
R
L
N
I
G
G
M
C
L
Q
D
S
P
L
G
I
---------
R
----
D
S
D
Y
----
N
S
A
F
P
A
G
V
N
V
A
A
T
W
D
K
N
L
A
Y
L
R
G
Q
A
M
G
Q
E
F
S
D
K
G
I
D
V
Q
L
G
P
A
A
G
P
L
-
G
R
S
P
D
G
G
R
N
W
E
G
F
S
P
D
P
A
L
T
G
V
L
F
A
E
T
I
K
G
I
Q
D
A
------
G
V
V
A
T
A
K
H
Y
I
L
N
E
Q
-
E
H
F
R
----------
Q
V
A
E
A
A
G
Y
GFNISD
T
I
S
S
N
V
D
D
K
T
I
H
E
M
Y
L
W
P
F
A
D
A
-
V
-
R
A
G
V
G
A
I
M
C
S
Y
N
Q
I
N
N
S
Y
G
C
Q
N
S
Y
T
L
N
K
L
L
K
A
E
L
G
-
F
Q
G
F
V
M
S
D
W
-
G
A
-
H
-
H
S
-----------
G
--
V
G
S
A
L
A
G
L
D
M
S
M
-
P
G
D
I
-
T
FDSA
T
S
F
----
W
G
T
------
N
L
T
I
A
V
-
L
N
G
T
V
P
Q
W
R
V
D
D
M
A
V
R
I
M
A
A
Y
-
Y
------
K
V
G
R
D
R
LYQPPNFSS
W
TRDEYGFKYFYP
Q
-
E
--------
G
---------------------------
P
-----
Y
E
K
----------------------------
V
N
H
FVNVQRN
H
S
E
V
I
R
K
L
G
A
D
S
T
V
L
L
K
N
N
-
N
A
L
P
L
T
G
K
E
R
-
K
V
A
I
L
G
E
D
A
G
-------------------
S
---------
N
S
Y
G
----------------
A
N
G
C
S
D
R
G
-
C
---
D
--
N
G
T
L
A
M
A
W
G
S
-
G
T
-----
A
--------
E
F
---------------------------------------------------------------------------------------------------
P
--
Y
------------------------
L
--------
V
T
--
P
E
Q
A
I
Q
----------
A
E
-------------------------
V
L
K
H
--
K
G
--------
S
----
V
--
Y
--------------
A
--
I
T
----
D
-------------
N
-----
W
------------
A
L
S
Q
V
E
T
L
A
K
Q
A
S
V
S
L
V
F
V
N
---
S
--------
D
--------
A
--------
G
E
G
Y
--------
I
----
S
V
----
D
GNEGDRNN
L
T
L
W
K
N
G
-
D
N
L
I
K
A
A
A
----
N
----
N
C
N
----
N
T
I
V
V
I
H
S
V
G
P
V
-
L
V
D
E
-
W
---
Y
---
D
HP
N
V
T
A
I
L
W
A
G
L
P
G
Q
E
S
G
N
S
L
A
D
V
L
Y
G
R
V
N
P
G
A
K
S
P
F
T
W
----
G
K
T
R
E
A
Y
G
D
Y
L
VRELNNGN
G
A
P
-------
Q
D
D
F
S
E
G
V
F
---
I
D
Y
R
G
F
D
K
R
N
E
T
P
I
Y
E
F
G
H
G
L
S
Y
T
T
F
N
Y
--
S
G
L
--------------
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.02
30%
-74
- C1 -
4IIC
15
BGL1_ASPAC
A:
[35-651]
--------------------------------
M
T
L
D
E
K
V
N
L
T
T
G
-
T
G
---------
W
E
L
E
K
---------
C
-
V
G
Q
T
G
-------------
G
V
P
R
L
N
I
G
G
M
C
L
Q
D
S
P
L
G
I
---------
R
----
D
S
D
Y
----
N
S
A
F
P
A
G
V
N
V
A
A
T
W
D
K
N
L
A
Y
L
R
G
Q
A
M
G
Q
E
F
S
D
K
G
I
D
V
Q
L
G
P
A
A
G
P
L
-
G
R
S
P
D
G
G
R
N
W
E
G
F
S
P
D
P
A
L
T
G
V
L
F
A
E
T
I
K
G
I
Q
D
A
------
G
V
V
A
T
A
K
H
Y
I
L
N
E
Q
-
E
H
F
R
----------
Q
V
A
E
A
A
G
Y
GFNISD
T
I
S
S
N
V
D
D
K
T
I
H
E
M
Y
L
W
P
F
A
D
A
-
V
-
R
A
G
V
G
A
I
M
C
S
Y
N
Q
I
N
N
S
Y
G
C
Q
N
S
Y
T
L
N
K
L
L
K
A
E
L
G
-
F
Q
G
F
V
M
S
D
W
-
G
A
-
H
-
H
S
-----------
G
--
V
G
S
A
L
A
G
L
D
M
S
M
-
P
G
D
I
-
T
FDSA
T
S
F
----
W
G
T
------
N
L
T
I
A
V
-
L
N
G
T
V
P
Q
W
R
V
D
D
M
A
V
R
I
M
A
A
Y
-
Y
------
K
V
G
R
D
R
LYQPPNFSS
W
TRDEYGFKYFYP
Q
-
E
--------
G
---------------------------
P
-----
Y
E
K
----------------------------
V
N
H
FVNVQRN
H
S
E
V
I
R
K
L
G
A
D
S
T
V
L
L
K
N
N
-
N
A
L
P
L
T
G
K
E
R
-
K
V
A
I
L
G
E
D
A
G
-------------------
S
---------
N
S
Y
G
----------------
A
N
G
C
S
D
R
G
-
C
---
D
--
N
G
T
L
A
M
A
W
G
S
-
G
T
-----
A
--------
E
F
---------------------------------------------------------------------------------------------------
P
--
Y
------------------------
L
--------
V
T
--
P
E
Q
A
I
Q
----------
A
E
-------------------------
V
L
K
H
--
K
G
--------
S
----
V
--
Y
--------------
A
--
I
T
----
D
-------------
N
-----
W
------------
A
L
S
Q
V
E
T
L
A
K
Q
A
S
V
S
L
V
F
V
N
---
S
--------
D
--------
A
--------
G
E
G
Y
--------
I
----
S
V
----
D
GNEGDRNN
L
T
L
W
K
N
G
-
D
N
L
I
K
A
A
A
----
N
----
N
C
N
----
N
T
I
V
V
I
H
S
V
G
P
V
-
L
V
D
E
-
W
---
Y
---
D
HP
N
V
T
A
I
L
W
A
G
L
P
G
Q
E
S
G
N
S
L
A
D
V
L
Y
G
R
V
N
P
G
A
K
S
P
F
T
W
----
G
K
T
R
E
A
Y
G
D
Y
L
VRELNNGN
G
A
P
-------
Q
D
D
F
S
E
G
V
F
---
I
D
Y
R
G
F
D
K
R
N
E
T
P
I
Y
E
F
G
H
G
L
S
Y
T
T
F
N
Y
--
S
G
L
--------------
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
79.85
30%
-71
- C1 -
4IIG
14
BGL1_ASPAC
A:
[35-650]
--------------------------------
M
T
L
D
E
K
V
N
L
T
T
G
-
T
G
---------
W
E
L
E
K
---------
C
-
V
G
Q
T
G
-------------
G
V
P
R
L
N
I
G
G
M
C
L
Q
D
S
P
L
G
I
---------
R
----
D
S
D
Y
----
N
S
A
F
P
A
G
V
N
V
A
A
T
W
D
K
N
L
A
Y
L
R
G
Q
A
M
G
Q
E
F
S
D
K
G
I
D
V
Q
L
G
P
A
A
G
P
L
-
G
R
S
P
D
G
G
R
N
W
E
G
F
S
P
D
P
A
L
T
G
V
L
F
A
E
T
I
K
G
I
Q
D
A
------
G
V
V
A
T
A
K
H
Y
I
L
N
E
Q
-
E
H
F
R
----------
Q
V
A
E
A
A
G
Y
GFNISD
T
I
S
S
N
V
D
D
K
T
I
H
E
M
Y
L
W
P
F
A
D
A
-
V
-
R
A
G
V
G
A
I
M
C
S
Y
N
Q
I
N
N
S
Y
G
C
Q
N
S
Y
T
L
N
K
L
L
K
A
E
L
G
-
F
Q
G
F
V
M
S
D
W
-
G
A
-
H
-
H
S
-----------
G
--
V
G
S
A
L
A
G
L
D
M
S
M
-
P
G
D
I
-
T
FDSA
T
S
F
----
W
G
T
------
N
L
T
I
A
V
-
L
N
G
T
V
P
Q
W
R
V
D
D
M
A
V
R
I
M
A
A
Y
-
Y
------
K
V
G
R
D
R
LYQPPNFSS
W
TRDEYGFKYFYP
Q
-
E
--------
G
---------------------------
P
-----
Y
E
K
----------------------------
V
N
H
FVNVQRN
H
S
E
V
I
R
K
L
G
A
D
S
T
V
L
L
K
N
N
-
N
A
L
P
L
T
G
K
E
R
-
K
V
A
I
L
G
E
D
A
G
-------------------
S
---------
N
S
Y
G
----------------
A
N
G
C
S
D
R
G
-
C
---
D
--
N
G
T
L
A
M
A
W
G
S
-
G
T
-----
A
--------
E
F
---------------------------------------------------------------------------------------------------
P
--
Y
------------------------
L
--------
V
T
--
P
E
Q
A
I
Q
----------
A
E
-------------------------
V
L
K
H
--
K
G
--------
S
----
V
--
Y
--------------
A
--
I
T
----
D
-------------
N
-----
W
------------
A
L
S
Q
V
E
T
L
A
K
Q
A
S
V
S
L
V
F
V
N
---
S
--------
D
--------
A
--------
G
E
G
Y
--------
I
----
S
V
----
D
GNEGDRNN
L
T
L
W
K
N
G
-
D
N
L
I
K
A
A
A
----
N
----
N
C
N
----
N
T
I
V
V
I
H
S
V
G
P
V
-
L
V
D
E
-
W
---
Y
---
D
HP
N
V
T
A
I
L
W
A
G
L
P
G
Q
E
S
G
N
S
L
A
D
V
L
Y
G
R
V
N
P
G
A
K
S
P
F
T
W
----
G
K
T
R
E
A
Y
G
D
Y
L
VRELNNGN
G
A
P
-------
Q
D
D
F
S
E
G
V
F
---
I
D
Y
R
G
F
D
K
R
N
E
T
P
I
Y
E
F
G
H
G
L
S
Y
T
T
F
N
Y
--
S
G
L
--------------
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
79.84
30%
-75
- C1 -
4IIH
13
BGL1_ASPAC
A:
[35-651]
--------------------------------
M
T
L
D
E
K
V
N
L
T
T
G
-
T
G
---------
W
E
L
E
K
---------
C
-
V
G
Q
T
G
-------------
G
V
P
R
L
N
I
G
G
M
C
L
Q
D
S
P
L
G
I
---------
R
----
D
S
D
Y
----
N
S
A
F
P
A
G
V
N
V
A
A
T
W
D
K
N
L
A
Y
L
R
G
Q
A
M
G
Q
E
F
S
D
K
G
I
D
V
Q
L
G
P
A
A
G
P
L
-
G
R
S
P
D
G
G
R
N
W
E
G
F
S
P
D
P
A
L
T
G
V
L
F
A
E
T
I
K
G
I
Q
D
A
------
G
V
V
A
T
A
K
H
Y
I
L
N
E
Q
-
E
H
F
R
----------
Q
V
A
E
A
A
G
Y
GFNISD
T
I
S
S
N
V
D
D
K
T
I
H
E
M
Y
L
W
P
F
A
D
A
-
V
-
R
A
G
V
G
A
I
M
C
S
Y
N
Q
I
N
N
S
Y
G
C
Q
N
S
Y
T
L
N
K
L
L
K
A
E
L
G
-
F
Q
G
F
V
M
S
D
W
-
G
A
-
H
-
H
S
-----------
G
--
V
G
S
A
L
A
G
L
D
M
S
M
-
P
G
D
I
-
T
FDSA
T
S
F
----
W
G
T
------
N
L
T
I
A
V
-
L
N
G
T
V
P
Q
W
R
V
D
D
M
A
V
R
I
M
A
A
Y
-
Y
------
K
V
G
R
D
R
LYQPPNFSS
W
TRDEYGFKYFYP
Q
-
E
--------
G
---------------------------
P
-----
Y
E
K
----------------------------
V
N
H
FVNVQRN
H
S
E
V
I
R
K
L
G
A
D
S
T
V
L
L
K
N
N
-
N
A
L
P
L
T
G
K
E
R
-
K
V
A
I
L
G
E
D
A
G
-------------------
S
---------
N
S
Y
G
----------------
A
N
G
C
S
D
R
G
-
C
---
D
--
N
G
T
L
A
M
A
W
G
S
-
G
T
-----
A
--------
E
F
---------------------------------------------------------------------------------------------------
P
--
Y
------------------------
L
--------
V
T
--
P
E
Q
A
I
Q
----------
A
E
-------------------------
V
L
K
H
--
K
G
--------
S
----
V
--
Y
--------------
A
--
I
T
----
D
-------------
N
-----
W
------------
A
L
S
Q
V
E
T
L
A
K
Q
A
S
V
S
L
V
F
V
N
---
S
--------
D
--------
A
--------
G
E
G
Y
--------
I
----
S
V
----
D
GNEGDRNN
L
T
L
W
K
N
G
-
D
N
L
I
K
A
A
A
----
N
----
N
C
N
----
N
T
I
V
V
I
H
S
V
G
P
V
-
L
V
D
E
-
W
---
Y
---
D
HP
N
V
T
A
I
L
W
A
G
L
P
G
Q
E
S
G
N
S
L
A
D
V
L
Y
G
R
V
N
P
G
A
K
S
P
F
T
W
----
G
K
T
R
E
A
Y
G
D
Y
L
VRELNNGN
G
A
P
-------
Q
D
D
F
S
E
G
V
F
---
I
D
Y
R
G
F
D
K
R
N
E
T
P
I
Y
E
F
G
H
G
L
S
Y
T
T
F
N
Y
--
S
G
L
--------------
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.82
30%
-74
- C1 -
4IIB
15
BGL1_ASPAC
A:
[35-650]
--------------------------------
M
T
L
D
E
K
V
N
L
T
T
G
-
T
G
---------
W
E
L
E
K
---------
C
-
V
G
Q
T
G
-------------
G
V
P
R
L
N
I
G
G
M
C
L
Q
D
S
P
L
G
I
---------
R
----
D
S
D
Y
----
N
S
A
F
P
A
G
V
N
V
A
A
T
W
D
K
N
L
A
Y
L
R
G
Q
A
M
G
Q
E
F
S
D
K
G
I
D
V
Q
L
G
P
A
A
G
P
L
-
G
R
S
P
D
G
G
R
N
W
E
G
F
S
P
D
P
A
L
T
G
V
L
F
A
E
T
I
K
G
I
Q
D
A
------
G
V
V
A
T
A
K
H
Y
I
L
N
E
Q
-
E
H
F
R
----------
Q
V
A
E
A
A
G
Y
GFNISD
T
I
S
S
N
V
D
D
K
T
I
H
E
M
Y
L
W
P
F
A
D
A
-
V
-
R
A
G
V
G
A
I
M
C
S
Y
N
Q
I
N
N
S
Y
G
C
Q
N
S
Y
T
L
N
K
L
L
K
A
E
L
G
-
F
Q
G
F
V
M
S
D
W
-
G
A
-
H
-
H
S
-----------
G
--
V
G
S
A
L
A
G
L
D
M
S
M
-
P
G
D
I
-
T
FDSA
T
S
F
----
W
G
T
------
N
L
T
I
A
V
-
L
N
G
T
V
P
Q
W
R
V
D
D
M
A
V
R
I
M
A
A
Y
-
Y
------
K
V
G
R
D
R
LYQPPNFSS
W
TRDEYGFKYFYP
Q
-
E
--------
G
---------------------------
P
-----
Y
E
K
----------------------------
V
N
H
FVNVQRN
H
S
E
V
I
R
K
L
G
A
D
S
T
V
L
L
K
N
N
-
N
A
L
P
L
T
G
K
E
R
-
K
V
A
I
L
G
E
D
A
G
-------------------
S
---------
N
S
Y
G
----------------
A
N
G
C
S
D
R
G
-
C
---
D
--
N
G
T
L
A
M
A
W
G
S
-
G
T
-----
A
--------
E
F
---------------------------------------------------------------------------------------------------
P
--
Y
------------------------
L
--------
V
T
--
P
E
Q
A
I
Q
----------
A
E
-------------------------
V
L
K
H
--
K
G
--------
S
----
V
--
Y
--------------
A
--
I
T
----
D
-------------
N
-----
W
------------
A
L
S
Q
V
E
T
L
A
K
Q
A
S
V
S
L
V
F
V
N
---
S
--------
D
--------
A
--------
G
E
G
Y
--------
I
----
S
V
----
D
GNEGDRNN
L
T
L
W
K
N
G
-
D
N
L
I
K
A
A
A
----
N
----
N
C
N
----
N
T
I
V
V
I
H
S
V
G
P
V
-
L
V
D
E
-
W
---
Y
---
D
HP
N
V
T
A
I
L
W
A
G
L
P
G
Q
E
S
G
N
S
L
A
D
V
L
Y
G
R
V
N
P
G
A
K
S
P
F
T
W
----
G
K
T
R
E
A
Y
G
D
Y
L
VRELNNGN
G
A
P
-------
Q
D
D
F
S
E
G
V
F
---
I
D
Y
R
G
F
D
K
R
N
E
T
P
I
Y
E
F
G
H
G
L
S
Y
T
T
F
N
Y
--
S
G
L
--------------
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------