@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0194: (2016-04-20 )
MRTNCWWRLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRVIDDAIAADHRPLAPWAVVLVAAAGATYLLMYVRRYYGGRIAHLVQHDLRMDAFQALLRWDGRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVAVMTWLSVPLALLAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERETVKLVTASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGSITVGTFVAFWACLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSPEARLSLEFQRVSFGYVADRPVLREISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVRELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIEEFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIECGIQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGTPDEVWERCPRYRELLSPAPDLADDLVVAERSPVCRPVAGLGTKAAQHTNVHNPGPHDHPPGPDPLRRLLREFRGPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHVLSALWWAALAGTATVVIRWVVQWGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLRTGLVVAVISVVTLVGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARHRLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVALLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAAVAAGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTVVFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGTVRDAIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALARARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEHGTVVEDGAHTELLAAGGHYSRLWAAHTRLCSPEITQLQCIDA
Atome Classification :
(49 SA)
------------------------------------------------.........10........20........30........40...--.....50....-.---------------...60..---------......70........80...--------.....90----........100.......110.......120.......-130.-.-..-...140.......150..-.....160.......170.......180.......190.......200.......210.......220..-.....230.......240.......250.......260........270.......280.......290..-.....300-------.........310.......----320..--...-..330--.--......340...--..-..--350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560...-----.----...570...---....580.......590.......600---..--.....----.610----------.......620-....----------------....630.-......640...---...---.650..--..-----------...--660.........670.......680.......690.......700.....--.--.710......--.------------720.......730...----....740.......750.......760...----....770.......780.......790.......800.......810.....----------..820.......830.......840.......850.......860.......870.....--.--.880..-.....890........900.......910.......920.--....-----..930.------........940.......950..-.-....960.......970.......980.......990....---...1000......1010........1020......1030.......1040-.-.--.-....-.1050......1060....-..1070......1080......1090......1100......1110......1120...--...1130.......1140.......1150......1160....--..1170......1180......1190.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------MRT
N
C
W
W
R
L
S
G
Y
V
M
R
H
R
R
D
L
L
L
G
F
G
A
A
L
A
G
T
V
I
A
V
L
V
P
L
V
T
K
R
V
--
I
D
D
A
IAADHRP-L---------------
A
P
W
A
V
V
L
---------
V
AAA
G
A
T
Y
L
L
M
Y
V
R
R
YYG
G
R
I
--------
A
H
L
V
Q
H
D
----
L
R
M
D
A
F
Q
A
L
L
RWDGRQQDRWSS
G
Q
L
I
V
R
TT
N
D
L
Q
L
V
Q
A
-
L
L
F
D
-
V
-
P
N
-
V
L
R
H
V
L
T
L
L
L
G
V
A
V
M
T
W
L
-
S
V
P
L
A
L
L
A
V
L
L
V
P
V
I
G
L
I
A
H
RS
R
R
L
L
A
A
A
T
H
C
A
Q
E
H
K
A
A
V
T
G
V
V
D
A
A
V
C
G
I
R
V
V
K
A
FGQEE
R
E
T
V
K
L
V
TA-SR
A
L
Y
A
A
Q
L
R
V
A
R
LNA
H
F
G
P
L
L
Q
T
L
P
A
L
G
Q
M
A
V
F
A
LG-GWMAAQG
S
I
T
V
G
T
F
V
A
F
W
A
C
L
T
L
LARP
A
C
D
L
A
G
-
M
L
T
I
A
Q
---------
Q
ARA
G
A
V
R
V
L
E
L
IDSRPTL----VDGTK--PLS-PE
A
R
L
--
S
--
L
E
F
Q
R
V
S
FGYVA--D
R
-
P
V
--
L
R
E
I
S
L
S
V
RAG
E
T
L
A
V
VGAPGS
G
K
S
T
L
A
S
L
A
T
R
C
Y
D
VT
Q
G
A
V
RIG
G
Q
D
V
R
E
L
T
L
D
S
L
R
S
A
IGLVPE
D
A
V
L
F
SGTIGANIAYGRPDA
T
P
E
Q
I
A
T
A
A
R
A
A
H
I
E
E
F
V
N
TLPD
G
Y
Q
T
AVGARGLTLSGG
Q
R
Q
R
I
A
L
A
R
A
L
LHQP
R
L
L
I
MDDP
T
S
A
V
D
A
V
I
E
C
G
I
Q
E
V
L
R
E
A
IADR
T
A
V
I
F
TRR
R
S
M
L
T
L
A
D
R
V
A
VLDSG
R
L
LDVG
T
P
D
E
V
W
E
R
C
P
R
Y
R
E
L
-----L----SPAPDL
A
D
D
---
L
V
VAERSPVCR
P
V
AGLGTKAAQHTNV----HN--PGPHD----HPP
G
----------
P
D
P
L
R
R
L
L
R
--
E
FR
G
----------------
P
L
A
L
S
L
L
L
-
V
A
V
Q
T
C
A
G
L
L
P
P
---
L
L
I
---RHGI
D
V
--
G
I
-----------
R
R
H
--
V
--
L
S
A
L
W
W
A
A
L
A
G
T
A
T
V
V
I
R
W
V
V
QWGS
A
M
VAGYT
G
E
Q
V
L
F
R
L
R
S
V
V
F
A
H
--
A
--
Q
RLGLDAFED--D------------GD
A
Q
I
V
T
A
V
TA
D
V
E
A
I
----
V
A
F
L
R
T
G
L
V
V
A
V
I
S
V
V
T
L
V
G
I
L
V
A
L
L
A
I
R
A
----
R
L
V
L
L
I
FTT
M
P
V
L
A
L
A
T
W
Q
F
RRASN
W
T
Y
R
R
A
R
H
R
L
G
T
V
T
A
T
L
R
E
Y
A
A
G
L
R
I
A
----------
Q
A
F
R
A
E
Y
R
G
L
Q
S
Y
FAHS
D
D
Y
R
R
LGVRG
Q
R
L
L
A
L
Y
Y
P
F
V
A
L
L
C
S
L
A
T
T
L
V
LLD
G
A
R
E
V
R
A
G
--
V
--
I
S
V
G
A
L
-
V
T
Y
L
L
Y
-
I
E
L
L
YT
P
I
G
E
L
A
Q
M
F
D
D
Y
Q
R
A
A
V
A
A
G
R
I
R
S
L
L
S--TRTP-----SSP--A------AR
P
V
G
TLRG
E
V
V
F
D
A
V
H
Y
S
YRTR-E-V
P
A
LA
G
I
N
L
R
IPAG
Q
T
V
V
F
VGSTGS
G
K
S
T
L
I
K
L
V
A
R
F
YDPT---H
G
T
V
R
VDGCD
L
R
EFD--VDGYRNRLG
I
V
T
Q
E
Q
Y
V
F
A
G-
T
V
R
D
A
I
AYG-R--P-D--A-
T
D
A
Q
-
V
E
R
A
A
R
E
VGAHP
M
I
T
ALDN-G
Y
L
H
Q
VTAGGRNLSA
G
Q
L
Q
L
L
A
L
A
R
A
RLVDP
D
I
L
L
L
DE
A
T
V
ALD
P
A
T
E
A
V
V
Q
R
A
T
L
T
L
A
--AR
R
T
T
L
-
I
V
AHG
L
A
I
A
-EHA
D
R
I
V
V
L
EHG
T
V
VEDGAH
T
E
L
L
AA--GG
H
Y
S
R
L
W
A
A
H
TRLCSPEI
T
Q
L
Q
CIDA
10
PsiBlast_PDB
87.90
28%
-113
- C1 -
4M2T
2
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
DSFS
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
------------------------------------------------------------TK
E
A
L
D
E
D
V
P
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
N
GGPPET
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
6
PsiBlast_PDB
87.77
28%
-113
- C1 -
4M1M
6
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
DSFS
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
------------------------------------------------------------TK
E
A
L
D
E
D
V
P
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
N
GGPPET
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
A
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
9
PsiBlast_PDB
87.68
28%
-113
- C1 -
4M2S
1
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
DSFS
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
------------------------------------------------------------TK
E
A
L
D
E
D
V
P
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
N
GGPPET
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
2
PsiBlast_PDB
85.36
28%
-108
- C1 -
4LSG
6
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
DS
F
S
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
T-----------------------------------------------------------L
D
E
D
V
P----
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
NGGPPE
T
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
A
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
8
PsiBlast_PDB
84.80
28%
-109
- C1 -
3G61
2
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
DSFS
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
T-----------------------------------------------------------L
D
E
D
V
P
----
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
N
GGPPE
T
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
5
PsiBlast_PDB
84.67
28%
-110
- C1 -
4KSD
-
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
DSFS
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
T-----------------------------------------------------------L
D
E
D
V
P----
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
N
GGPPE
T
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
3
PsiBlast_PDB
84.53
28%
-110
- C1 -
4KSB
-
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
DSFS
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
T-----------------------------------------------------------L
D
E
D
V
P----
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
N
GGPPE
T
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
7
PsiBlast_PDB
84.47
28%
-109
- C1 -
3G60
1
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
D
S
F
S
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
T-----------------------------------------------------------L
D
E
D
V
P----
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
NGGPPE
T
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
1
PsiBlast_PDB
84.43
28%
-106
* C1 *
3G5U
5
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
D
S
F
S
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
T-----------------------------------------------------------L
D
E
D
V
P----
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
N
G
G
P
P
E
T
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
A
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
4
PsiBlast_PDB
84.39
28%
-109
- C1 -
4KSC
-
MDR1A_MOUSE
A:
[141-1263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
-
G
I
G
D
-
K
-
I
G
-
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
---
L
E
R
Y
-
N
N
N
L
E
E
A
K
-
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
-
F
W
Y
G
T
--
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
---
L
I
G
-
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
DSFS
K
S
G
H
K
--
P
D
N
-
I
Q
G
----
N
--
L
E
F
K
N
I
H
F
S
Y
P
S
--
R
K
-
E
V
QI
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
-----
V
M
T
Q
T-----------------------------------------------------------L
D
E
D
V
P----
P
A
S
F
W
R
I
L
K
L
N
S
T
E
W
----------------
P
Y
F
V
V
G
I
F
-
C
A
I
-
I
N
G
G
L
Q
P
A
---
F
S
V
---
I
F
S
K
V
V
--
G
V
F
T
N
GGPPE
T
Q
R
Q
N
S
--
N
--
L
F
S
L
L
F
L
I
L
G
-----
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
--
M
--
L
R
Q
D
V
S
W
F
D
D
--
P
KNT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
----
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
----------
Q
S
L
Q
I
P
Y
R
N
--------------
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
--
L
--
M
T
F
E
N
V
-
L
L
V
F
S
A
-
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
T
P
EIDSY
S
T
Q
--
G
------
L
K
P
-
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
-
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
--
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
A
Y
G
-
D
--
N
-
S
RV
V
-
S
Y
E
E
-
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
-
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
S
T
I
-
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
-----------------------
114
HHSearch
74.37
26%
-115
- C1 -
4F4C
2
PGP1_CAEEL
A:
[145-1306]
--------------------------------------------------------------------------------------------------------------------------------------------
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
--------
A
E
Q
M
N
N
R
----
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
-
G
T
G
D
-
K
I
G
M
-
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
-
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
-
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
-
V
G
W
V
H
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
-
Q
L
A
V
L
G
---------
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
V
I
----
D
S
S
S
K
A
G
R
K
D
-
M
K
I
K
G
--
D
--
I
T
V
E
N
V
H
F
T
Y
P
S
RP
D
V
-
P
I
--
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
E
G
I
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
Q
G
L
Y
Y
D
L
-----
V
----
T
A
-
Q
T
F
T
D
A
V
D
S
A
A
E
G
----------------------ER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
E
N
N
A
Q
----------
K
T
N
L
F
E
I
L
Y
--
H
A
R
P
----------------
H
A
L
S
L
F
I
G
-
M
S
T
A
T
I
G
G
F
I
Y
P
---
T
Y
S
V
F
F
T
S
F
M
N
V
--
F
A
-----------
G
N
P
AD
F
--
L
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
--
V
--
L
S
Q
H
I
G
F
F
D
S
PQ
N
------------
A
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
----
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
----
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
----------
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
T
D
--
P
PT
M
Q
P
M
R
V
-
L
R
V
M
Y
A
-
I
T
I
S
T
S
T
L
G
F
A
T
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
--
K
I
S
K
-----
I
D
S
LS
L
------
A
G
E
K
K
K
L
Y
G
K
V
I
F
K
N
V
R
F
A
Y
P
E
R
P
E
-
I
E
I
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
E
I
K
T
L
N
--
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
D
C
-
S
I
A
E
N
I
I
Y
G
-
L
--
D
-
P
SS
V
-
T
M
A
Q
-
V
E
E
A
A
R
L
A
N
I
H
N
F
I
A
E
L
P
E
-
G
F
E
T
R
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
N
T
V
-
M
N
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
--
K
--------------------------
105
Fugue
73.29
26%
-115
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRD
E
V
V
N
K
V
S
I
P
Q
L
Y
R
Y
T
T
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
-
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
---------
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
----
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
-
I
-
G
M
-
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
-
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
-
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
-
V
G
W
V
H
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
-
Q
L
A
V
L
G
---------
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
V
I
----
D
S
S
S
K
--
A
G
R
-
K
D
M
K
I
K
G
D
--
I
T
V
E
N
V
H
F
T
Y
P
S
RP
D
V
-
P
I
--
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
E
G
I
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
Q
G
L
Y
Y
D
L
-----
V
----
T
A
Q
T
F
T
D
A
V
---
D
S
A
A
E
G
E
R
I
-------
G
K
D
A
L
S
R
L
K
Q
----
E
L
--
E
E
N
N
A
----
Q
K
T
N
----------
L
F
E
I
L
Y
H
A
R
--
P
H
A
L
----------------
S
L
F
I
G
M
S
T
-
A
T
I
G
G
F
I
Y
P
T
Y
S
---
V
F
F
---
T
S
F
M
N
V
F
A
G
N
-----------
P
A
D
--
F
--
L
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
--
V
L
S
Q
H
I
G
F
F
D
S
P
Q
--
N
------------
A
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
----
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
----
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
----------
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
T
D
PP
T
--
M
Q
P
M
R
V
-
L
R
V
M
Y
A
-
I
T
I
S
T
S
T
L
G
F
A
T
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
--
K
I
S
K
ID---
S
L
S
--
L
------
A
G
E
K
K
K
L
Y
G
K
V
I
F
K
N
V
R
F
A
Y
P
E
R
P
E
-
I
E
I
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
E
I
K
T
L
N
--
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
D
C
-
S
I
A
E
N
I
I
Y
G
-
L
DP
S
-
S
--
V
-
T
M
A
Q
-
V
E
E
A
A
R
L
A
N
I
H
N
F
I
A
E
L
P
E
-
G
F
E
T
R
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
N
T
V
-
M
N
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
--
K
--------------------------
11
PsiBlast_PDB
71.52
28%
-118
- C1 -
4F4C
2
PGP1_CAEEL
A:
[163-1306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------
A
E
Q
M
N
N
R
----
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
-
G
T
G
D
K
I
-
G
M
-
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
-
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
-
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
-
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
-
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
---------
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
V
I
----
D
S
S
S
K
--
A
G
R
-
K
D
M
K
I
--
K
G
D
I
T
V
E
N
V
H
F
T
Y
P
S
RP
D
V
-
P
I
--
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
E
G
I
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
----
T
D
A
V
D
S
A
A
E
---
G
------------------------------------------
E
R
I
G
----------
K
D
A
L
S
R
L
K
Q
--
E
L
E
E
NNAQKTN
L
F
E
I
L
Y
H
A
R
P
H
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
---
T
S
F
M
N
V
F
A
G
N
-----------
P
A
D
--
F
--
L
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
--
Q
H
I
G
F
F
D
S
P
Q
--
N
------------
A
S
G
K
I
S
T
R
L
A
T
D
V
P
N
--------
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
----------
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
T
D
--
P
--
P
T
M
Q
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
T
L
G
F
A
T
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KI
S
K
I
D
-----
S
L
S
--
L
------
A
G
E
K
K
K
L
Y
G
K
V
I
F
K
N
V
R
F
A
Y
P
E
R
P
E
-
I
E
I
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
E
I
K
T
L
N
--
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
D
C
-
S
I
A
E
N
I
I
Y
G
L
D
--
P
-
S
--
S
V
T
M
A
Q
-
V
E
E
A
A
R
L
A
N
I
H
N
F
I
A
E
L
P
E
-
G
F
E
T
R
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
--
E
G
R
T
C
I
-
V
I
A
H
R
L
N
T
V
-
M
N
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
--
K
--------------------------
129
HHSearch
65.67
28%
-111
- C1 -
3WMG
3
?
A:
[32-598]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
I
A
-
S
I
L
E
G
A
T
L
P
A
F
A
---
I
V
F
---
G
R
M
F
Q
V
--
F
T
-----------
K
S
K
--
S
Q
I
E
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
--
L
--
V
E
Q
D
V
T
Y
F
D
R
--
R
------------
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
----
Q
Y
S
F
S
K
L
-
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
----
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
----------
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
--
S
--
L
N
L
G
N
L
-
L
T
A
F
F
S
-
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
--
R
V
P
Q
-----
Y
R
R
--
P
DPG
A
E
V
V
T
Q
P
L
V
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
P
T
R
-
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
--
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
-
T
I
R
D
N
I
L
Y
G
-
K
--
R
-
D
--
A
-
T
D
E
E
-
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
-
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
G
V
T
S
V
-
V
I
A
H
R
L
S
T
V
-
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
-------------
126
HHSearch
65.19
31%
-106
- C1 -
4Q4H
-
Y288_THEMA
B:
[26-589]
------------------------------------------------------
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
--
I
D
V
V
F
V
P
R
R
F
D
L
L
---------------
P
R
Y
M
L
I
L
---------
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
--------
S
Q
D
V
V
F
R
----
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
-
S
I
I
Q
-
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
-
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
-
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
-
Q
F
N
M
I
Q
---------
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
----
D
D
P
D
A
--
V
E
L
-
R
E
V
R
G
--
E
--
I
E
F
K
N
V
W
F
S
Y
D
K
--
K
K
-
P
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
Y
Y
E
L
-----
F
----
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
64.87
24%
-108
- C1 -
4RY2
-
?
A:
[161-720]
-----------------------------------------------------------
F
L
K
P
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
--
F
D
D
L
I
K
F
E
K
L
N
D
L
---------------
H
I
I
S
A
G
F
---------
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
--------
G
M
S
I
D
K
S
----
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
-
A
I
S
G
-
A
T
L
T
-
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
-
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
-
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
-
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
-
L
Q
P
L
I
Q
---------
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
----
E
L
-------------
G
--
D
--
I
E
F
R
N
V
D
F
R
Y
G
L
--
R
K
-
P
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
N
E
N
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
K
G
C
Y
F
K
M
-----
W
----
K
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
64.54
27%
-109
- C1 -
4Q4H
-
?
A:
[3-569]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
R
Y
L
K
--
P
Y
W
I
----------------
F
A
V
L
A
P
L
F
-
M
V
V
E
V
I
C
D
L
S
Q
P
---
T
L
L
---
A
R
I
V
D
E
--
G
I
-----------
A
R
G
--
D
--
F
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
--
V
--
L
S
F
S
I
S
N
V
N
R
--
F
------------
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
----
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
----
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
----------
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
N
N
--
Q
--
M
E
I
G
S
I
-
M
A
Y
T
N
Y
-
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
--
E
K
P
A
-----
I
E
E
--
A
DN----
A
L
A
L
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
-
T
-
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
--
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
L
K
W
G
-
R
--
E
-
D
--
A
-
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
-
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
--
K
G
C
T
T
F
-
I
I
T
Q
K
I
P
T
A
-
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
---------------
24
PsiBlast_CBE
64.31
32%
-104
- C1 -
3QF4
2
?
A:
[43-574]
-------------------------------------------------------------------------------------
P
T
L
L
A
R
I
--
V
D
E
G
I
A
R
G
D
F
S
-
L
---------------
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
----------------
D
----
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
-
L
V
M
M
-
L
-
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
-
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
-
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
-
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
-
I
L
N
F
I
V
---------
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
----
E
E
A
D
N
--
A
L
A
L
P
N
V
E
G
--
S
--
V
S
F
E
N
V
E
F
R
Y
F
E
--
N
T
D
P
V
--
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
E
D
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
K
P
Y
R
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.66
30%
-108
- C1 -
3QF4
1
Y288_THEMA
B:
[27-588]
-------------------------------------------------------
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
--
I
D
V
V
F
V
P
R
R
F
D
-
L
---------------
L
P
R
Y
M
L
I
---------
L
---
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
--------
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
S
I
-
I
Q
-
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
-
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
-
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
-
Q
F
N
M
I
Q
---------
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
----
D
D
P
D
A
--
V
E
L
-
R
E
V
R
G
--
E
--
I
E
F
K
N
V
W
F
S
Y
D
K
--
K
K
-
P
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
Y
Y
E
L
-----
F
----
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.63
30%
-106
- C1 -
4Q4H
-
Y288_THEMA
B:
[27-588]
-------------------------------------------------------
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
--
I
D
V
V
F
V
P
R
R
F
D
-
L
---------------
L
P
R
Y
M
L
I
---------
L
---
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
--------
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
S
I
-
I
Q
-
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
-
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
-
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
-
Q
F
N
M
I
Q
---------
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
----
D
D
P
D
A
--
V
E
L
-
R
E
V
R
G
--
E
--
I
E
F
K
N
V
W
F
S
Y
D
K
--
K
K
-
P
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
Y
Y
E
L
-----
F
----
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.04
30%
-107
- C1 -
4Q4A
1
Y288_THEMA
B:
[27-588]
-------------------------------------------------------
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
--
I
D
V
V
F
V
P
R
R
F
D
-
L
---------------
L
P
R
Y
M
L
I
---------
L
---
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
--------
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
S
I
-
I
Q
-
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
-
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
-
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
-
Q
F
N
M
I
Q
---------
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
----
D
D
P
D
A
--
V
E
L
-
R
E
V
R
G
--
E
--
I
E
F
K
N
V
W
F
S
Y
D
K
--
K
K
-
P
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
P
G
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
Y
Y
E
L
-----
F
----
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
42.62
36%
-89
- C1 -
3VX4
3
?
D:
[31-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
G
F
G
-
R
--
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
--
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
-
S
I
M
D
N
L
V
L
G
-
A
--
K
-
E
--
G
-
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
-
G
Y
Q
T
E
L
S
D
G
A
-
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
---
T
E
K
T
I
I
-
F
V
A
H
R
L
S
I
S
-
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
G
F
Y
Y
N
L
F
-------------------
72
PsiBlast_CBE
42.56
36%
-88
- C1 -
3VX4
3
?
A:
[31-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
G
F
G
-
R
--
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
--
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
-
S
I
M
D
N
L
V
L
G
-
A
--
K
-
E
--
G
-
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
-
G
Y
Q
T
E
L
S
D
G
A
-
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
---
T
E
K
T
I
I
-
F
V
A
H
R
L
S
I
S
-
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
G
F
Y
Y
N
L
F
-------------------
54
PsiBlast_CBE
40.50
39%
-85
- C1 -
2FGJ
2
D:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
62
PsiBlast_CBE
39.99
39%
-85
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[1-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
57
PsiBlast_CBE
39.58
39%
-84
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
51
PsiBlast_CBE
39.56
39%
-83
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
49
PsiBlast_CBE
39.48
39%
-85
- C1 -
2FGK
2
D:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
61
PsiBlast_CBE
39.46
39%
-86
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[1-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
45
PsiBlast_CBE
39.40
40%
-87
- C1 -
2PMK
1
A:
[3-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
60
PsiBlast_CBE
39.30
39%
-85
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[1-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
58
PsiBlast_CBE
39.26
39%
-84
- C1 -
2FFA
2
A:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
53
PsiBlast_CBE
39.26
39%
-85
- C1 -
2FFB
1
A:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
46
PsiBlast_CBE
39.19
40%
-83
- C1 -
2FF7
1
A:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
52
PsiBlast_CBE
38.83
39%
-82
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
76
PsiBlast_CBE
38.81
36%
-79
- C1 -
2IXF
5
TAP1_RAT
A:
[2-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
-----
L
S
G
--
S
------
L
A
P
L
-
N
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
N
-
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
I
A
Y
G
-
L
--
T
R
T
--
P
-
T
M
E
E
-
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
-
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
EW
A
S
R
T
V
L
-
L
I
T
H
Q
L
S
L
A
-
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
--------------------
48
PsiBlast_CBE
38.77
40%
-86
- C1 -
3B5J
1
A:
[3-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
75
PsiBlast_CBE
38.48
36%
-77
- C1 -
2IXF
4
TAP1_RAT
B:
[2-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
-----
L
S
G
--
S
------
L
A
P
L
-
N
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
N
-
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
I
A
Y
G
-
L
--
T
R
T
--
P
-
T
M
E
E
-
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
-
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
EW
A
S
R
T
V
L
-
L
I
T
H
Q
L
S
L
A
-
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
--------------------
59
PsiBlast_CBE
38.41
39%
-83
- C1 -
1XEF
3
D:
[1-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
44
PsiBlast_CBE
38.25
37%
-83
- C1 -
5DGX
1
A:
[8-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------
S
K
E
L
A
K
V
D
G
N
V
T
I
K
D
L
S
F
A
F
G
E
H
-
K
-
V
--
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
E
L
T
--
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
-
T
V
Y
N
N
I
A
F
G
------
E
--
V
-
S
E
E
E
-
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
-
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
T
--
K
S
C
T
T
I
-
V
I
A
H
R
L
S
T
V
-
E
N
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
--
G
G
L
Y
T
R
L
Y
Q
S
-----------------
50
PsiBlast_CBE
38.22
39%
-80
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
55
PsiBlast_CBE
38.15
39%
-81
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
56
PsiBlast_CBE
37.88
39%
-81
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[7-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
-
N
--
P
-
G
--
M
-
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
-
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
-
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------------------
96
PsiBlast_CBE
31.39
32%
-70
- C1 -
3C4J
4
?
B:
[33-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
G
S
L
-
E
-
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
TN
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------------
P
M
K
-
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
--
P
Q
H
------------------------
94
PsiBlast_CBE
30.63
32%
-69
- C1 -
3C41
3
?
K:
[12-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
G
S
L
-
E
-
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
TN
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------------
P
M
K
-
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
--
P
Q
H
------------------------
97
PsiBlast_CBE
30.40
32%
-65
- C1 -
3C4J
3
?
A:
[33-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
G
S
L
-
E
-
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
TN
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------------
P
M
K
-
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
--
P
Q
H
------------------------
98
PsiBlast_CBE
30.37
32%
-70
- C1 -
2Q0H
4
?
B:
[33-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
G
S
L
-
E
-
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
TN
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------------
P
M
K
-
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
--
P
Q
H
------------------------
95
PsiBlast_CBE
29.28
32%
-69
- C1 -
3C41
3
?
J:
[12-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
G
S
L
-
E
-
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
TN
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------------
P
M
K
-
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
--
P
Q
H
------------------------
99
PsiBlast_CBE
28.50
32%
-65
- C1 -
2Q0H
4
?
A:
[33-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
G
S
L
-
E
-
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
TN
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------------
P
M
K
-
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
--
P
Q
H
------------------------