@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0197: (2016-04-20 )
MTSSDWLPTACILCECNCGIVVQVDDRRLARIRGDKAHPGSAGYTCNKALRLDHYQNNRARLSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKIFYYGGGGQGNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGGHTRGEFENAEVSVFVGKNPWMSQSFPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQPGCDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQRCGVDEELLRAAARRIGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILTGNFAKKGGQHLHSSFAPLFSQVSGRTPVTGAPIIAGLIPGNVVPEEILTEHPDRFRAMIVERGNPAHSLADSAACRAAFQALELMVVVDVAMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFPPLPGTLPEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVAKLTAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNALFDAILERPSGVTFTVHNYEDDFALISHPDHKIALEIPEMLAEIRSLTQTPSRLTTPQLPIVLSVGERRAYTANDIFRDPSWRKRDANGALRVSVEDAQALGLADGCLARITTAAGSAEATVEVTETMLAGHAALPNGFGLDYTGDDGRTVVAGVAPNALTSTRWRDPYAGTPWHKHVPAAIRRADAESPIWYPKWAILPARGVLA
Atome Classification :
(20 SA)
-------.........10.....--....20....-----------------------------------------.-------------------------------------------.-------------------------------------------..30--...-------.------....-40-------........50....-----...------.-----60.....-..-----.70------------------------------------.........80........90........100...----.-----------------.----.-.110.......120.-.-..-...--130..-----.....140.......150-.--------.......160.......170.......-------180--..---...--------------.-.----190........200.....------..--------210------.........220.......230..------.....240.....----------------------------------------------------------------------.---------.-------------------------------------------------------------------------------------------------250--------..-----------------------------------------------------------------------------------------------------------------------------------------------------------...-.------..260.......270.......280------...------.------...290.....-...300.......310.......320.-------...---..-----------------.330-------.-..------..--.--.------340------.------------------------.--.-.-----.--.--------.-----.------------------.-----------------350-.---.----.----------.--.----.----------.-----------------------.------.------------360--------------------------..----------.-----------.-...370.........380.......390--.------------------------------.--..-------------------------------.-.----..-.-400.......410.........420.......430.......440.......450.......460.......470...--.-----------.---..--480----.---..----.-..------.----------------.490---....-..-----------------.---.----------500----.---........-----510-------.........520.......530.......540.......---550-.-..---------.-....560.---------....-----..570-.-......580.......590.....--.--.----600.......--------------610.......620--....-...630-..--.-.-...-.-640--..-.......650.......660.......670..--.....680-........690.......700.---.--------....-.710-.......---------------720........--------------730---------------..-......740.......750.......760-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MTSSDWL
P
T
A
-
C
I
L
C
E--CNC
G
I
V
V
Q
VD-----------------------------------------D-------------------------------------------
R
-------------------------------------------
R
L
A
R
--IRG-------D------KAHP-GS-------AGYTCN
K
A
L
R
LDHY-----QN
N
------
R
-----
A
R
L
S
S
P
M
-
R
R
-----RA-------------------------------------DGTYEEIDW
D
T
A
I
V
E
I
A
E
G
F
K
Q
I
R
DTHGG
D
K
I
F
Y
Y----G-----------------G----G-GQGNHLG
G
A
Y
S
G
A
F
L
-
K
-
A
L
-
G
S
R
--
Y
RSNA-----LAQEKTG
E
A
W
V
D
F
Q
L
YG--G--------HTRGEFENA
E
V
S
V
F
VGKNPWMSQSF
P
R
-------
A
R
V
--
V
L
---
N
E
I
--------------A-K----D-PG
R
S
M
I
V
IDPVVTDTAK------
M
A
--------
D
--------
F
H
L
R
VQPGC
D
A
W
C
L
A
A
L
A
A
V
L
V
Q
E
------NLC
N
E
A
F
L
A
A
H
VH----------------------------------------------------------------------
G
---------
V
-------------------------------------------------------------------------------------------------
D
T
---------
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
-
Q
------EV
P
V
A
D
Y
A
Q
RCGV
D
E
E
L
L
R
A
A
A
R
RI------GTA------
A
------
S
V
S
V
-
F
E
D
LGI-QQAP
N
S
T
V
C
S
Y
L
N
K
L
L
W
I
LTG
N
F
A
K
KG-------
G
Q
H
---
L
H
-----------------
S
S
F
A
-------
P
-
L
F
------
S
Q--V--S------G--------R------------------------T--P-V-----T--G--------A-----P------------------
I
-----------------
I
---
A
---G----L----------I--P----G----------N-----------------------V------V------------
P
E
E
--------------------------
I
L
----------T-----------E-H
P
D
R
--
F
R
A
M
I
V
ERGN
P
A
H
S
L
A
D
S
A
A
----
C
------------------------------
R
--
A
A
-------------------------------
F
-
Q
----
A
L
-
E
-
L
M
V
V
V
D
V
A
M
T
E
--
T
A
R
L
A
H
Y
VLP
A
A
SQFEKPE
A
T
F
F
N
F
EFPRNG
F
Q
LRRPLFPPLPGTLP
E
P
E
I
W
A
R
L
V
R
A
LGVVDEA--
D
-----------
L
---
R
P
--
L
R
-----
E
---
A
A
----A-Q
G
------
R
----------------
Q
A
-
Y
---
T
E
A
F
-
L
A
-----------------A---A----------A------T---N
P
T
V
A
K
L
T
-----
A
---------
Y
V
L
Y
E
TLGPTLPD
G
L
A
G
A
A
A
L
W
G
L
A
Q
K
T
A
MA
Y
P
D
A
V
R
RA---G-H-A-D
G
---------
N
-
A
L
F
D
A
I
LE---------RPS
G
-----
V
T
F
T
V
-H-NYED
D
F
A
L
ISHPD
H
K
I
A
L
E
I
P
E
M
L
--
A
--
E
----
I
R
S
L
TQTPSR--------------LTTPQL
P
I
V
L
SVG--ERRA-YT
A
N
D--IF--R-D-PSW-R-K----RD-AN
G
A
L
R
V
S
VED
A
Q
ALGL
A
D
G
C
L
A
R
I
TTAAGSA--
E
A
T
V
E
V
T
--
E
T
M
LAGHAALPNGFGLDYTGDD---G--------
R
T
V
V
-AGVA-PNALTST---------------R-WRDPYAGTP--------------WH----------------K
H
-
V
P
A
A
I
R
RADAESPIWYP
K
W
A
ILPARGVLA-
44
HHSearch
93.25
21%
-68
* C3 *
2E7Z
8
AHY_PELAE
A:
[2-727]
-------------
K
H
V
V
-
C
Q
S
C
D
--
I
N
C
V
V
E
A
E
V
K
A----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
I
Q
T
--
K
S
I
-------
S
------
E
P
H
P
T
T
P
-------
P
N
S
I
C
M
K
S
V
N
A
D
T
I
-----
R
T
H
------
K
-----
D
R
V
L
Y
P
L
-
K
N
-----
V
G
SKRG---------------------------------
E
Q
R
W
E
R
I
S
W
D
Q
A
L
D
E
I
A
E
K
L
K
K
I
I
A
K
Y
G
P
E
S
L
G
V
S
----
Q
-----------------
T
----
E
-
I
N
Q
Q
S
E
Y
G
T
L
-
R
R
F
M
-
N
-
L
L
-
G
S
P
--
N
W
T
S
A
-----
M
Y
M
C
I
G
N
T
A
G
V
H
R
V
T
H
G
--
S
--------
Y
S
F
A
S
F
A
D
S
N
C
L
L
F
I
G
K
N
L
S
N
H
N
W
V
S
Q
-------
F
N
---
D
L
---
K
A
A
----------------
L
----
K
-
R
G
C
K
L
I
V
L
D
P
R
R
T
K
V
A
E
------
M
A
--------
D
--------
I
W
L
P
L
R
Y
G
T
D
A
A
L
F
L
G
M
I
N
V
I
I
N
E
------
Q
L
Y
D
K
E
F
V
E
N
W
C
V
----------------------------------------------------------------------
G
---------
F
-------------------------------------------------------------------------------------------------
E
E
---------
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
V
-
Q
------
E
Y
P
L
D
K
V
A
E
I
T
G
C
D
A
G
E
I
R
K
A
A
V
M
F
------
A
T
E
------
S
------
P
A
S
I
-
P
W
A
V
S
T
-
D
M
Q
K
N
S
C
S
A
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R
A
Q
C
I
L
R
A
I
V
G
S
F
V
N
-
G
-------
A
E
I
---
L
G
-----------------
A
P
H
S
DLV----
P
-
I
S
------
K
I
--
Q
--
M
HEALP
E
E
--------
K
------------------------
K
--
K
L
Q
-----
L
--
G
--------
T
ETY--
P
FLTY--------------
T
GMSAL
E
E
P
S
E
R
------
V
---
Y
---
G
----
V
KYFHNMGAFM
A
--
N
----
P
----------
T
-----------------------
A
------
L
------------
F
T
A
--------------------------
M
A
----------
T
-----------
E
-
K
P
Y
P
--
V
K
A
F
F
A
L
A
S
N
A
L
M
G
Y
A
N
Q
Q
N
----
A
------------------------------
L
--
K
G
-------------------------------
L
-
M
----
N
Q
-
D
-
L
V
V
C
Y
D
Q
F
M
T
P
--
T
A
Q
L
A
D
Y
V
L
P
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D
H
W
L
E
R
-
P
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V
Q
P
N
W
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G
I
-
P
F
G
N
T
S
Q
Q
V
V
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P
A
G
E
A
K
D
E
Y
Y
F
I
R
E
L
A
V
R
M
G
L
E
E
H
---------------
F
----
P
--
W
K
------------------
D
------
R
----------------
L
E
-
L
---
I
N
Y
R
-
I
S
--------------------------------------------------------------------------
P
T
-------------------
G
M
E
W
E
E
Y
Q
K
Q
---
Y
T
Y
-
M
-
S
K
---------
L
-
P
D
Y
--------------------------------
F
G
P
E
G
V
G
V
A
T
P
S
G
K
V
E
L
Y
S
S
V
F
E
--
K
--
L
G---
Y
D
P
L
P
Y
Y
H
E
P
LQTEISD
P
------
E
L
A
K
E
Y
P
L
I
L
F
A
G
--
L
R
E
D
-
S
N
F
Q
S
--
C
Y
--
H
-
Q
-
P
G
I
-
L
-
R
D
---
A
E
-
P
D
P
V
A
L
L
H
P
K
T
A
Q
S
L
G
L
P
S
G
E
W
I
W
V
E
T
T
H
G
R
L
--
K
L
L
L
K
H
D
--
G
A
Q
P
E
G
T
I
R
I
P
H
G
R
W
C
P
E
Q
E
G
G
PET
G
--------
F
S
G
A
-
M
L
H
N
D
A
M
V
L
S
D
D
---------------
D
W
N
L
D
P
E
Q
G
L
P
--------------
N
L
----------------
R
G
G
I
L
A
K
A
Y
K
C
----------------------
50
HHSearch
86.14
21%
-68
- C3 -
2NAP
5
NAPA_DESDA
A:
[5-723]
---------
P
E
K
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
A
V
A
--
I
Q
G
-------
N
------
P
N
N
--
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
-----
L
N
S
------
K
-----
E
R
V
T
Q
P
L
-
V
R
-----
R
H
K------------------------------------
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
-----------------
S
----
G
-
Q
C
L
T
E
E
S
Y
V
A
-
N
K
I
F
K
G
-
G
F
-
G
T
N
--
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
--
K
DEPM----
G
T
Y
A
D
I
D
Q
A
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C
F
F
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N
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S
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A
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P
V
L
F
-------
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----
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---
A
R
R
--------------
K
Q
V
----
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-
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K
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D
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R
R
T
N
T
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R
------
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A
--------
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--------
M
H
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A
F
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P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
M
D
AEGKPSD
F
-------------------------------------------------------------------------------------------------
E
G
---------
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
-
E
------
N
Y
R
P
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K
V
A
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V
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------
A
T
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-
L
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Q
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V
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N
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---
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-------
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------
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G
--
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RD
G
------
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--------
A
------------------------
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--
S
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A
--
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RA------
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-----
P
N
A
K
H
R
-------------
A
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----------------
M
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K
L
W
---
G
----
L
PEGRIAPEPG
Y
--
H
----
T
----------
V
-----------------------
A
------
L
------------
F
E
A
--------------------------
L
-------------------------
G
R
G
D
--
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K
C
M
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C
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P
N
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N
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----
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------------------------------
H
--
K
A
-------------------------------
M
-
S
----
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P
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F
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A
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D
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L
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A
F
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C
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D
G
V
Y
G
C
G
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---
R
R
Y
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L
T
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Q
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--------------
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----
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--
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-----
N
------------
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------
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-----------------
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-
V
---
W
N
E
W
-
R
M
-----------------
V
---
S
----------
K
------
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----
T
T
Y
D
--
F
-----
W
---------
G
M
T
R
E
R
L
R
K
E
-------
S
G
L
I
W
P
C
P
S
E
-------
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H
P
-----
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-
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--------------
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L
R
Y
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-------------
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-----
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--
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--
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--------------
A
A
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--------------
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P
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Y
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--
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W
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AT
M
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F
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D
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-------------------------
K
K
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V
N
K
L
F
L
D
-----------------
A
T
D
P
V
S
R
E
P
--------------
E
Y
----------------
K
I
-
C
A
A
R
V
R
K
A
----------------------
47
HHSearch
84.77
17%
-57
- C3 -
4YDD
9
?
A:
[26-898]
----------
K
K
T
R
G
A
H
-
L
V
N
C
T
--
G
A
C
P
H
F
V
Y
S
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
V
V
M
R
--
E
E
Q
-------
S
KDIAPM
P
N
I
P
-
E
Y
-------
N
P
R
G
C
N
K
G
E
C
G
H
D
Y
-----
M
Y
G
------
P
-----
H
R
I
K
Y
P
L
-
I
R
-----
V
G
ERG----------------------------------
E
G
K
W
R
R
A
T
W
E
E
A
L
D
M
I
A
D
K
C
V
D
T
I
K
N
H
A
P
D
C
I
S
V
Y
----
S
-----------------
P
----
V
-
P
A
V
S
P
V
S
F
S
A
G
H
R
F
A
-
H
-
Y
I
-
G
A
H
--
A
H
T
F
Y
-----
D
W
Y
G
D
H
P
T
--
G
Q
T
Q
T
C
G
--
V
Q
G
D
T
----
C
E
T
A
D
W
F
N
S
K
Y
I
I
L
W
G
S
N
P
T
Q
T
R
I
P
D
A
--------
H
---
F
L
---
S
E
A
----------------
Q
----
L
-
N
G
A
K
I
V
S
I
S
P
D
Y
N
S
S
T
I
------
K
V
--------
D
--------
K
W
I
H
P
Q
P
G
T
D
G
A
L
A
M
A
M
A
H
V
I
I
K
E
------
K
L
Y
D
A
H
S
L
K
E
Q
T
D
----------------------------------------------------------------------
L
---------
S
Y
L
V
R
SDTKRFLREADVVAGGSKD
K
F
Y
F
W
NAKTG
K
P
V
I
P
K
GSWGDQPE
K
K
G
S
P
VGFLGRNTFAFPKGYIDLGD
L
D
P
A
L
E
G
K
F
N
M
Q
L
LDG
K
T
V
E
V
R
P
V
F
E
I
---------
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
M
A
------
D
N
T
P
E
K
A
A
K
I
T
G
V
T
A
K
A
I
T
E
L
A
R
E
F
------
A
T
A
------
K
------
P
S
M
I
-
I
C
G
G
G
T
-
Q
H
W
Y
Y
S
D
V
L
L
R
A
M
H
L
L
T
A
L
T
G
T
E
G
T
N
G
-------
G
G
M
---
N
H
-----------------
Y
I
G
Q
-------
W
-
K
P
------
A
F
--
V
--
A
------
G
--------
L
------------------------
V
--
A
-
L
A
----
F
PE
G
--------
V
-----
N
------------------
K
Q
R
F
C
Q
T
T
----------
I
---
W
---
T
----
Y
----------
I
--
H
A
EVN
D
EIISSDID
T
E
K
-----------------------
Y
------
L
------------
R
D
S
--------------------------
I
T
T
GQ
M
P
N
M
---
P
-----------
E
-
Q
G
R
D
--
P
K
V
F
F
V
Y
R
G
N
W
L
N
Q
A
K
G
Q
K
Y
----
V
------------------------------
L
--
E
N
-------------------------------
L
W
P
----
K
L
-
E
-
L
I
V
D
I
N
I
R
M
D
S
--
T
A
L
Y
S
D
V
V
L
P
S
A
H
W
Y
E
K
L
-
D
L
N
V
T
S
E
--
H
S
Y
I
N
M
T
E
P
A
I
K
P
M
W
E
S
K
T
D
W
Q
I
F
L
A
L
A
K
R
V
E
M
A
A
K
R
K
-
K
-----------
Y
---
E
K
--
F
N
-----
D
------------
E
------
K
----------------
F
K
-
W
---
V
R
D
L
-
S
------------------
N
---
L
----------
W
------
N
-----
Q
M
T
M
D
G
-----
K
---------
L
A
E
D
E
A
A
A
Q
Y
I
L
D
--------
N
A
P
--
Q
S
K
G
I
T
I
Q
M
L
R
E
K
---
P
-
Q
-
R
-
F
K
---------
S
-
N
-
W
T
S
P
L
-----------
K
E
G
-----
V
P
Y
T
P
-
F
Q
Y
F
V
V
D
K
K
P
W
P
T
L
T
G
R
Q
Q
F
Y
L
D
H
D
T
--
F
F
D
M
----
G
V
E
L
P
T
Y
K
A
P
--------------
I
D
A
D
K
Y
P
F
R
F
N
S
P
--
H
S
R
H
--
S
V
H
S
--
T
F
--
K
D
N
-
V
L
M
-
L
-
R
L
---
Q
R
-
G
G
P
S
I
E
M
S
P
L
D
A
K
P
L
G
I
K
D
N
D
W
V
E
A
W
N
N
H
G
K
V
--
I
C
R
V
K
I
R
--
N
G
E
Q
R
G
R
V
S
M
W
H
C
P
E
L
Y
M
D
L
L
-------------------
T
G
G
-
S
Q
S
V
C
P
V
R
I
N
PTNLVGNYGH
L
F
F
-
R
P
N
Y
Y
G
P
A
G
--------------
S
Q
----------------
R
D
-
V
R
V
N
V
K
R
Y
I
G
A
T
P
I
S
---------------
56
HHSearch
84.70
19%
-53
- C3 -
1G8K
5
AIOA_ALCFA
A:
[13-812]
---------
N
A
Q
R
T
N
M
T
-
C
H
F
C
I
--
V
G
C
G
Y
H
V
Y
K
W
-----------------------------------------
P
-------------------------------------------
E
L
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
Y
D
I
M
--
V
V
P
-------
D
------
K
A
C
V
-
V
N
-------
S
G
L
S
S
T
R
G
G
K
M
A
S
Y
-----
M
Y
T
------
P
TGDGK
E
R
L
S
A
P
R
-
L
Y
-----
A
--------------------------------------
A
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
----
C
-----------------
F
DHGG
A
-
G
G
G
F
E
N
T
W
G
T
-
G
K
L
M
F
S
-
A
I
-
Q
T
P
--
M
V
R
I
H
NRPAY
N
S
E
C
H
A
T
R
E
----
M
G
I
G
EL
N
--------
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
S
Q
T
N
Y
F
-------
L
N
H
--
W
L
P
N
L
Q
G
A
T
T
S
K
K
K
E
R
F
PN---
E
-
N
----
F
-
P
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
------
I
A
R
H
V
AGNDR
V
--------
L
H
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
------
G
W
I
D
K
P
F
I
E
A
H
T
K
----------------------------------------------------------------------
G
---------
F
-------------------------------------------------------------------------------------------------
D
D
---------
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
--
N
------
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
------
Y
K
P
KASGQA
P
------
R
T
M
H
-
A
Y
E
K
G
I
-
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
-------
T
G
C
---
V
R
-----------------
M
G
G
H
-------
Q
--
E
------
G
Y
------------------------------------------------------------
T
--------
R
-----
P
------------------
P
-----------------
Y
---
P
---
G
----
D
-------------
K
----
K
----------
I
-----------------------
Y
------
I
------------
D
Q
E
--------------------------
L
I
-------------------------
K
G
K
--
G
R
I
M
T
W
W
G
C
N
N
F
Q
T
S
N
N
A
Q
A
----
L
R
E
A
I
L
Q
R
S
A
I
V
K
Q
A
M
Q
K
ARGAT
T
E
E
M
V
D
V
I
Y
--
E
A
-------------------------------
T
-
Q
----
N
G
G
L
-
F
V
T
S
I
N
L
Y
P
T
K
--
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
-
N
L
T
S
M
N
G
E
---
R
R
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
C
L
I
A
A
R
I
A
N
A
L
R
D
M
Y
Q
K
--
D
G----------
K
---
A
E
--
M
A
-----
A
Q
F
E
G
F
D---
W
-
K
T
------
E
----------------
E
D
-
A
---
F
N
D
G
-
F
R
-----------------
R
---
A
----------
G
------
Q
---
P
-
G
A
---------
P
-----------
A
I
D
S
Q
G
G
--
S
T
--------------
G
H
L
V
T
Y
D
R
L
R
K
S
GNN
G
-
V
-
Q
-
L
P
---------
V
-
V
S
W
D
E
--------------
S
K
-----
G
L
V
G
T
---
E
M
L
Y
T
E
G
K
F
D
T
D
D
G
K
A
H
F
K
P
A
P
W
------------
N
G
L
P
A
T
V
Q
---------------
Q
Q
K
D
K
Y
R
F
W
L
N
N
G
--
R
N
N
E
V
W
Q
T
A
Y
--
H
D
--
Q
-
Y
-
N
S
L
-
M
Q
E
----
R
Y
-
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
S
T
--
F
A
M
V
Y
P
V
--
A
E
I
K
R
G
Q
T
F
M
L
F
G
Y
V
N
-------------------------
G
I
-
Q
G
D
V
T
T
------------------
D
W
T
D
R
D
I
I
P
--------------
Y
Y
----------------
K
G
-
T
W
G
D
I
R
K
V
G
S
M
S
E
-----------------
45
HHSearch
84.23
21%
-61
- C3 -
2VPZ
4
?
A:
[36-750]
---------
E
V
K
S
V
Y
Q
I
-
C
E
G
C
F
--
W
R
C
G
I
V
A
H
A
V
-----------------------------------------
G
-------------------------------------------
N
-------------------------------------------
R
V
Y
K
--
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
-----
T
Y
D
------
P
-----
D
R
L
K
R
P
L
-
I
R
-----
V
E
GSQRG--------------------------------
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
----
G
-----------------
H
----
G
-
T
G
----
D
Y
W
F
V
D
F
L
P
-
A
-
A
W
-
G
S
P
--
N
A
A
K
P
S----
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
--
R
PIGG----
H
E
P
I
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
N
T
Q
-------
L
Q
D
---
F
---
A
L
A
----------------
L
----
K
-
N
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
------
K
A
--------
H
--------
R
W
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
------
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------------------------------------------
G
---------
F
-------------------------------------------------------------------------------------------------
E
E
---------
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
V
-
K
------
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
------
A
A
H
------
K
------
P
R
A
V
-
L
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
-------
G
F
Y
---
I
A
-----------------
Q
S
P
Y
L
E
K
YPLP
P
-
L
P
------
L
E
P
-
A
--
A
------
G
--------
G
------------------------
C
SG
P
-
S
-----
G
--
G
--------
D
-----
H
------------------
E
-----------------
P
---
E
---
G
----
F
KPRADKGKF-
F
--
A
RSTA
I
----------
Q
-----------------------
E
------
L
------------
I
E
P
--------------------------
M
I
----------
T
-----------
G
-
E
P
Y
P
--
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
----
T
------------------------------
K
--
E
A
-------------------------------
L
-
K
----
N
L
-
D
-
L
Y
V
A
I
D
V
L
P
Q
E
--
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
-
Y
D
D
F
V
L
V
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
E
Q
Y
F
--
P
-----------
W
--------
K
------------------
T
------
I
----------------
E
E
-
Y
---
L
E
T
R
-
L
Q
-----------------
S
---
L
--------------------------------------------
G
L
D
L
E
-----------------------------
T
M
K
G
M
---
G
-
T
L
V
Q
R
G
---------
K
-
P
W
L
E
D
W
-----------------------------
E
K
E
G
R
L
P
F
G
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
--
E
--
A
G---
H
Q
P
L
P
V
F
T
P
P
--------------
E
E
P
P
E
G
F
Y
R
L
L
Y
G
--
R
S
P
V
--
H
T
F
A
--
R
T
--
Q
-
N
-
N
W
V
-
L
-
M
E
---
M
D
-
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
G
P
V
R
V
K
P
T
--
A
R
I
R
K
D
C
V
Y
I
V
H
G
F
G
H
K
A
P
L
M
----
R
--------
L
A
H
G
-
R
G
A
S
-
D
N
Y
L
Q
T
R
---------------
Y
-
K
L
D
P
I
S
G
G
A
--------------
G
L
----------------
R
V
-
N
F
V
R
L
E
K
A
E
R
P
R
L
P
----------------
72
Fugue
82.78
20%
-54
- C3 -
2VPZ
4
?
A:
[30-763]
---APWY
A
Q
E
V
K
S
V
Y
Q
I
-
C
E
G
C
F
--
W
R
C
G
I
V
A
H
A
V
-----------------------------------------
G
-------------------------------------------
N
-------------------------------------------
R
V
Y
K
--
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
-----
T
Y
D
------
P
-----
D
R
L
K
R
P
L
-
I
R
VEGSQ
R
G
-------------------------------------
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
----
G
-----------------
H
----
G
-
T
G
D
Y
W
F
----
V
D
F
L
P
-
A
-
A
W
-
G
S
P
--
N
A
A
K
P
-----
S
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
--
G
RPIGG---
H
E
P
I
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
-
G
E
D
T
H
N
T
-------
Q
L
Q
--
D
F
---
A
L
A
--------------
L
-
K
------
N
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
------
K
A
--------
H
--------
R
W
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
------
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------------------------------------------
G
---------
F
-------------------------------------------------------------------------------------------------
E
E
---------
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
V
-
K
------
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
------
A
A
H
------
K
------
P
R
A
V
L
P
P
T
R
H
N
-
V
W
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
-------
G
F
Y
---
I
A
-----------------
Q
S
---------
P
-
Y
L
------
E
K
-----
Y
------
P
--------
L
------------------------
P
--
P
-
L
-----
P
--
L
--------
E
-----
P
------------------
A
-----------------
A
---
G
---
G
----
C
----------
S
--
G
----
P
----------
S
-----------------------
G
------
G
------------
D
H
E
PEGFKPRADKGKFFARSTA
I
Q
E
L
I
E
P
M
I
----------
T
-----------
G
-
E
P
Y
P
--
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
----
T
------------------------------
K
--
E
A
-------------------------------
L
-
K
----
N
L
-
D
-
L
Y
V
A
I
D
V
L
P
Q
E
--
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
-
Y
D
D
F
V
L
V
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
----------------------------------------------
L
E
------
Q
----------------
Y
F
-
P
---
W
K
T
I
-
E
E
-----------------
Y
---
L
----------
E
------
T
---
R
L
Q
S
L
G
L
D
-----
L
---------
E
T
M
K
G
M
G
T
L
V
Q
R
--------------------------------------------------------
G
---------
K
P
W
L
-----
E
D
W
E
K
-
E
-
G
R
L
P
F
G
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
E
A
G
H
--
Q
--
P
----
L
P
V
F
T
P
P
E
E
-----------------
P
P
E
G
F
Y
R
L
L
Y
G
--
R
S
P
V
-
H
T
F
A
R
--
T
Q
--
N
-
N
-
W
V
L
-
M
-
E
----
M
D
-
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
--
E
G
P
V
R
V
K
--
P
T
A
R
I
R
K
D
C
V
Y
I
V
H
G
F
G
H
K
A
P
L
---
M
--------
R
L
A
H
G
R
G
A
S
-
D
N
Y
L
Q
T
R
---------------
Y
-
K
L
D
P
I
S
G
G
A
--------------
G
L
----------------
R
V
-
N
F
V
R
L
E
K
A
E
R
P
R
L
---
P
S
L
T
G
L
A
K
R
P
F
D
E
R
73
Fugue
82.71
18%
-50
- C3 -
1G8K
6
AIOA_ALCFA
A:
[4-825]
ND
R
I
T
L
P
P
A
N
A
Q
R
T
N
M
T
-
C
H
F
C
I
--
V
G
C
G
Y
H
V
Y
K
W
-----------------------------------------
P
EL
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
-------------------------------------------
Y
D
I
M
--
V
V
P
-------
D
------
K
A
C
V
-
V
N
-------
S
G
L
S
S
T
R
G
G
K
M
A
S
Y
MYTPT
G
D
G
------
K
-----
E
R
L
S
A
P
R
-
L
Y
-----
A
--------------------------------------
A
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
C
F
DH
G
-----------------
G
----
A
-
G
G
G
F
E
N
T
W
G
T
G
K
L
M
F
-
S
-
A
I
-
Q
T
P
MV
R
I
H
N
R
-----
P
A
Y
N
S
E
C
H
A
T
R
E
M
G
I
G
E
--
L
N-------
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
S
Q
T
N
Y
F
-------
L
N
H
--
W
L
---
P
N
L
Q
GAT
T
S
K
K
K
E
R
F
PN
E
-
N
----
F
-
P
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
------
I
A
--------
R
H
V
AGNDRV
L
H
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
------
G
W
I
D
K
P
F
I
E
A
H
T
K
----------------------------------------------------------------------
G
---------
F
-------------------------------------------------------------------------------------------------
D
D
---------
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
--
N
------
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
YKPKAS
G
Q
A
------
P
------
R
T
M
H
-
A
Y
E
K
G
I
-
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
TGCVRMG
G
H
Q
E
G
Y
T
R
-----------------
P
P
Y
P
-------
G
-
D
K
------
K
I
--
Y
--
I
------
D
--------
Q
------------------------
E
--
L
-
I
-----
K
--
G
--------
K
-----
G
------------------
R
-----------------
I
---
M
---
T
----
W
W
GCNNFQ---
T
--
S
----
N
----------
N
-----------------------
A
------
Q
------------
A
L
R
--------------------------
E
A
----------
I
-----------
L
-
Q
R
S
A
--
I
V
K
Q
A
M
Q
K
A
R
G
A
T
T
E
E
M
V
D
V
----
I
------------------------------
Y
--
E
A
-------------------------------
T
-
Q
----
N
G
-
G
L
F
V
T
S
I
N
L
Y
P
T
K
--
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
-
N
L
T
S
M
N
G
E
---
R
R
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
C
L
I
A
A
R
I
A
N
A
L
R
D
M
Y
Q
K
--
D
-----------
G
---
K
A
--
E
M
-----
A
---
A
Q
----
F
-
E
G
FDWKT
E
E
----------------
D
A
-
F
---
N
D
G
F
-
R
R
-----------------
A
---
G
----------
Q
------
P
---
G
A
P
A
I
D
S
Q
-----
G
---------
G
S
T
G
H
L
V
T
Y
D
R
L
R
K
S
G
N
N
G
V
Q
L
P
V
V
S
W
D
--------------------------------------------------
E
S
K
G
-----
L
V
G
T
E
-
M
-
L
Y
T
E
G
--
K
F
D
T
D
D
G
K
A
H
F
K
P
A
P
-------------
W
N
G
L
P
A
T
V
Q
--------------
Q
Q
K
D
K
Y
R
F
W
L
N
N
G
R
N
N
E
V
W
-
Q
T
A
Y
H
--
D
Q
--
Y
-
N
-
S
L
M
-
Q
-
E
----
R
Y
-
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
S
T
--
F
A
M
V
Y
P
V
--
A
E
I
K
R
G
Q
T
F
M
L
F
G
Y
V
N
G
-------------------------
I
-
Q
G
D
V
T
T
D
---------------
W
--
T
D
R
-
D
I
I
P
--------------
Y
Y
----------------
K
G
-
T
W
G
D
I
R
K
V
G
S
M
S
E
F
K
R
T
---
V
S
F
K
S
R
R
F
G
-
53
HHSearch
81.35
19%
-55
- C3 -
3ML1
5
NAPA_CUPNH
A:
[11-802]
---------
K
L
K
W
S
K
A
P
-
C
R
F
C
G
--
T
G
C
G
V
T
V
A
V
K
-----------------------------------------
D
-------------------------------------------
N
-------------------------------------------
K
V
V
A
--
T
Q
G
-------
D
------
P
Q
A
E
-
V
N
-------
K
G
L
N
C
V
K
G
Y
F
L
S
K
I
-----
M
Y
G
------
Q
-----
D
R
L
T
R
P
L
-
M
R
-----
M
K
NGKYDK-------------------------------
N
G
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
G
M
F
----
G
-----------------
S
----
G
-
Q
W
T
V
W
E
G
Y
A
A
-
A
K
L
Y
-
K
A
G
F
-
R
S
N
--
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
--
M
DEPM----
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
M
H
P
I
L
W
-------
T
R
----
V
---
T
D
R
--------------
R
-
L
----
S
H
P
K
T
R
V
V
V
L
S
T
F
T
H
R
C
F
D
------
L
A
--------
D
--------
I
G
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
------
N
K
V
N
K
D
F
V
N
K
H
T
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
------------------------------------
T
---------
F
-------------------------------------------------------------------------------------------------
D
E
---------
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
V
-
S
------
K
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
L
Y
------
A
D
P
------
N
I
-----
K
V
M
S
-
L
W
T
M
G
F
-
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
G
-------
N
S
P
---
F
S
-----------------
L
T
G
Q
-------
P
S
A
C
------
G
T
--
A
RE
V
------
G
--------
T
------------------------
F
--
S
-
H
RL---
P
--
A
--------
D
MVVTN
P
------------------
K
H
----------------
R
E
E
A
E
R
I
W
K
LPPG
T
----------
I
--
P
----
D
----------
K
PGYD
A
------------------
V
------
L
------------
Q
N
R
--------------------------
M
L
------------------------
K
D
G
K
--
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
--
L
----
M
------------------------------
E
--
E
G
-------------------------------
L
-
P
G
Y
R
N
P
A
-
N
-
F
I
V
V
S
D
A
Y
P
T
V
--
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
-
E
G
A
Y
G
N
A
E
---
R
R
T
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
L
W
Q
L
V
E
F
A
K
R
F
K
V
E
E
V
W
--
P
-----------
P
---
E
L
I
A
K
K
-----
P
---
E
Y
----
K
G
K
T
------
L
----------------
Y
D
V
L
---
Y
R
N
G
Q
V
D
KFPLKDVNAEYHN
A
E
A
K
A
---
F
----------
G
FY
L
Q
K
G
L
---
F
E
E
Y
A
T
F
G
RGHGH
D
---------
L
A
P
F
D
A
Y
H
E
-------
A
R
G
L
R
W
P
V
V
N
G
K
E
-----
T
R
--------
W
-
R
-
Y
R
---------
E
--
G
S
D
P
Y
V
K
---------------------------
A
G
T
G
F
Q
F
Y
G
N
P
D
G
K
A
V
I
F
A
L
P
Y
-----------------
E
P
P
A
E-------------
S
P
D
K
E
Y
P
Y
W
L
V
T
G
--
R
V
L
E
--
H
W
H
S
GS
M
T
--
R
-
R
-
V
P
E
L
Y
-
R
----
S
F
-
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
R
M
--
R
S
R
I
E
T
R
GR
D
A
P
P
R
G
L
V
F
V
P
W
F
D
-------------------------
A
S
Q
L
-
I
N
K
V
T
L
D
-----------------
A
T
C
P
I
S
L
Q
T
--------------
D
F
----------------
K
K
-
C
A
V
K
I
V
K
V
----------------------
55
HHSearch
81.08
17%
-61
- C3 -
2IVF
11
?
A:
[80-976]
--------------
G
S
H
-
L
N
I
C
W
PQ
G
S
C
K
F
Y
V
Y
V
R
-----------------------------------------
N
-------------------------------------------
G
-------------------------------------------
I
V
W
R
--
E
E
Q
-------
A
------
A
Q
T
P
-
A
C
NVDYVDY
N
P
L
G
C
Q
K
G
S
A
F
N
N
N
-----
L
Y
G
------
D
-----
E
R
V
K
Y
P
L
-
K
R
-----
V
G
KRG----------------------------------
E
G
K
W
K
R
V
S
W
D
E
A
A
G
D
I
A
D
S
I
I
D
S
F
E
A
Q
G
S
D
G
F
I
L
D
----
A
-----------------
P
HVHA
G
-
S
I
A
W
G
A
G
F
R
M
-
T
Y
L
M
-
D
-
G
V
S
P
D
I
--
N
---------
V
D
I
G
D
--
T
Y
M
G
A
F
H
T
F
G
--
K
MH
M
G
----
Y
S
A
D
N
L
L
D
A
E
L
I
F
M
T
C
S
N
W
S
Y
T
Y
P
S
S
Y
--------
H
---
F
L
---
S
E
A
----------------
R
----
Y
-
K
G
A
E
V
V
V
I
A
P
D
F
N
P
T
T
P
------
A
A
--------
D
--------
L
H
V
P
V
R
V
G
S
D
A
A
F
W
L
G
L
S
Q
V
M
I
D
E
------
K
L
F
D
R
Q
F
V
C
E
Q
T
D
LP
L
L
V
R
MDTGKFLSAEDVDGGEAK
Q
F
Y
F
F
D
EKAG
S
V
R
K
A
S
RGTLKLDFMPAL
E
G
T
F
S
A
R
L
KNG
K
T
I
Q
V
R
T
V
---------
F
-------------------------------------------------------------------------------------------------
E
G
---------
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
L
-
K
------
D
Y
T
P
E
K
A
S
A
K
C
G
V
P
V
S
L
I
R
E
L
G
R
K
V
------
A
K
K
-------------
R
T
C
S
-
Y
I
G
F
S
S
-
A
K
S
Y
H
G
D
L
M
E
R
S
L
F
L
A
M
A
L
S
G
N
W
G
K
P
G
-------
T
G
A
---
F
A
-----------------
W
A
Y
S
-------
D
D
N
M
V
Y
L
G
VM
S
K
PT
A
--
Q
------
G
--------
G
------------------------
M
--
D
-
E
L
H
Q
M
A
E
--
G
F
N
K
R
T
L
E
A
D
-----
P
------------------
T
ST
D
E
M
G
N
I
E
F
M
K
V
V
T
S
-
A
---
V
---
G
----
L
----------
V
--
P
----
P
A
M
W
L
Y
Y
HVGY
D
-----------------------
Q
L
W
N
NKA
W
TDPALKKS
F
G
A
Y
L
D
E
--------------------------
A
K
E
K
GWWTNDHI
R
-----------
P
A
P
D
K
T
--
P
Q
V
Y
M
L
L
S
Q
N
P
M
R
R
K
R
S
G
A
K
----
M
------------------------------
F
P
D
V
L
-------------------------------
F
-
P
----
K
L
-
K
-
M
I
F
A
L
E
T
R
M
S
S
--
S
A
M
Y
A
D
I
V
L
P
C
A
W
Y
Y
E
K
H
-
E
M
T
T
P
C
S
-
G
N
P
F
F
T
F
V
D
R
S
V
A
P
P
G
E
C
R
E
E
W
D
A
I
A
L
I
L
K
K
V
G
E
R
A
A
A
R
-
G
-----------
L
---
T
E
--
F
N
-----
D
---
H
N
G
R
--
K
-
R
R
------
Y
----------------
D
E
-
L
---
Y
K
K
F
-
T
M
-----------------
D
--------------
G
-----------------------
H
---------
L
L
T
N
E
D
C
L
K
E
M
V
D
I
N
R
A
V
G
-
V
F
-----
A
K
D
Y
T
Y
E
K
F
K
K
E
---
G
-
Q
-
T
R
F
L
SMGTG----
V
-
S
R
Y
A
H
A
N
E
---------
V
D
V
T
-----
K
P
I
Y
P
-
M
R
W
H
F
D
D
K
K
V
F
P
T
H
T
R
R
A
Q
F
Y
L
D
H
D
W
Y
L
E
--
A
----
G
E
S
L
P
T
H
K
D
T
P-------------
M
V
G
G
D
H
P
F
K
I
T
G
G
--
H
P
R
V
--
S
I
H
S
--
T
H
--
L
-
T
-
N
S
H
-
L
S
R
----
L
H
R
G
Q
P
V
V
H
M
N
S
K
D
A
A
E
L
G
I
K
D
G
D
M
A
K
L
F
N
D
F
A
D
C
--
E
I
M
V
R
T
A
--
P
N
V
Q
P
K
Q
C
I
V
Y
F
W
D
A
H
Q
Y
K
G
--------------------
W
K
P
-
Y
D
I
L
L
I
G
MP-------------
K
-
P
L
H
L
A
G
G
Y
E
QFRYYFMNGSPAPV
T
D
----------------
R
G
-
V
R
V
S
I
K
K
A
----------------------
57
HHSearch
80.60
19%
-57
- C3 -
4AAY
5
?
A:
[16-830]
---------
D
A
K
K
H
N
V
T
-
C
H
F
C
I
--
V
G
C
G
Y
H
A
Y
T
W
P
IN
K
Q
G
G
TDPQNNIFGVDLS
E
Q
Q
Q
A
ESDAWYSPSM
Y
N
V
V
K
Q
D
-------------------------------------------
G
-------------------------------------------
R
D
V
H
V
V
I
K
P
-------
D
------
H
E
C
V
-
V
N
-------
S
G
L
G
S
V
R
G
A
R
M
A
E
T
-----
S
F
S
EARNTQ
Q
-----
Q
R
L
T
D
P
L
-
V
W
-----
R
--------------------------------------
Y
G
Q
M
Q
P
T
S
W
D
D
A
L
D
L
V
A
R
V
T
A
K
I
V
K
E
K
G
E
D
A
L
I
V
S
A
F
DH
G
-----------------
G
----
A
-
G
G
G
Y
E
N
T
W
G
T
-
G
K
L
Y
F
E
-
A
M
-
K
V
K
--
N
I
R
I
H
-----
N
R
P
A
Y
N
S
E
V
H
G
T
-
R
D
M
G
VG
E
LN------
N
C
Y
E
D
A
E
L
A
D
T
I
V
A
V
G
T
N
A
L
E
T
Q
T
N
Y
F
-------
L
N
H
--
W
I
---
P
N
L
R
GES
L
G
K
K
K
E
L
M
PE
E
-
P
----
H
-
E
A
G
R
I
I
I
V
D
P
R
R
T
V
T
V
N
A
C
E
Q
T
A
G
A
--------
D
NV------
L
H
L
A
I
N
S
G
T
D
L
A
L
F
N
A
L
F
T
Y
I
A
D
K
------
G
W
V
D
R
D
F
I
D
K
S
T
L
----------------------------------------------------------------------
R
---------
E
G
T
A
R
P
PLYPARGVSEANP
G
H
L
----------------------------------------------------------------------------
S
S
---------
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
V
-
E
G
C
----
R
M
S
I
E
E
A
A
E
I
T
G
L
D
A
A
Q
I
I
K
A
A
E
W
I
------
G
M
P
------
K
EGG
K
R
R
R
V
M
F
-
G
Y
E
K
G
L
-
I
W
G
N
D
N
Y
R
T
N
G
A
L
V
N
L
A
L
A
T
G
N
I
G
R
P
G
-------
G
G
V
---
V
R
-----------------
L
G
G
H
-------
Q
--
E
------
G
Y
--
V
--
R
------
P
--------
S
------------------------
D
--
A
-
H
-----
V
--
G
--------
R
-----
P
AAY
V
--------------
D
Q
L
---------------
L
---
I
---
G
----
G
Q---------
G
G
V
H
H
I
W
G
C
----------
D
-----------------------
H
------
Y
------------
K
T
T
--------------------------
L
N
----------
A
H
E
F
--------
K
-
R
V
Y
K
--
K
R
T
D
M
V
K
D
A
M
S
A
A
P
Y
G
D
R
E
A
M
V
N
A
I
------------------------------
V
--
D
A
-------------------------------
I
-
N
----
Q
G
G
L
-
F
A
V
N
V
D
I
I
P
T
K
--
I
G
E
A
C
H
V
I
L
P
A
A
T
S
G
E
M
-
N
L
T
S
M
N
G
E
---
R
R
M
R
L
T
E
R
Y
M
D
P
P
G
Q
S
M
P
D
C
L
I
A
A
R
L
A
N
T
M
E
R
V
L
T
E
--
M
G----------
D
---
V
G
--
Y
A
-----
A
---
Q
F
KGFD
W
-
Q
T
------
E
----------------
E
D
-
A
---
F
M
D
G
-
Y
N
-----------------
K
----------------------------
N
A
H
G
G
-----
E
---------
F
V
T
Y
E
R
L
S
A
M
G
-----
T
N
G
F
Q
E
P
A
T
G
-------------------------------------
F
---------------
T
D
G
-----
K
I
E
-
G
-
T
-
Q
R
L
Y
T
D
G
V
F
S
T
D
D
G
K
A
R
F
M
D
A
P
W
R
--
G
--
L
----
Q
A
P
--
G
--
K
Q
--------------
Q
Q
K
D
S
H
K
Y
L
I
N
N
G
--
R
A
N
V
--
V
W
Q
S
--
A
Y
LD
Q
-
E
-
N
D
F
V
M
-
D
----
R
F
-
P
Y
P
F
I
E
M
N
P
E
D
M
A
E
A
G
L
K
E
G
D
L
V
E
I
Y
N
D
A
G
A
T
--
Q
A
M
A
Y
P
T
--
P
T
A
R
R
G
E
T
F
M
L
F
G
F
P
T
-------------------------
G
V
-
Q
G
N
V
T
S
A
-----------------
G
T
N
E
-
L
I
I
P
--------------
N
Y
----------------
K
Q
-
T
W
G
N
I
R
K
I
S
D
A
P
R
-----------------
54
HHSearch
80.24
18%
-65
- C3 -
1TMO
3
TORA_SHEMA
A:
[39-815]
---------------
E
W
-
L
T
T
G
S
--
H
F
G
A
F
K
M
K
R
K
-----------------------------------------
N
-------------------------------------------
G
-------------------------------------------
V
I
A
E
--
V
K
P
-------
F
------
D
L
D
K
-
Y
P
-----------
T
D
M
I
N
G
I
R
G
M
-----
V
Y
N
------
P
-----
S
R
V
R
Y
P
M
-
V
R
-----
L
D
F
L
L
KGHKSNTHQRG-----------------------
D
F
R
F
V
R
V
T
W
D
K
A
L
T
L
F
K
H
S
L
D
E
V
Q
T
Q
Y
G
P
S
G
L
H
A
G
----
Q
-----------------
T
----
G
W
R
A
T
G
Q
L
H
S
S
T
-
S
H
M
Q
-
R
-
A
V
-
G
M
H
G
N
Y
V
K
K
I
-----
G
D
Y
S
T
G
A
G
Q
T
I
L
P
Y
V
L
G
--
S
TEVYAQGT
S
W
P
L
I
L
E
H
S
D
T
I
V
L
W
S
N
D
P
Y
K
N
L
Q
V
G
W
NAETH
E
S
F
A
Y
L
A
Q
L
---
K
E
K
--------------
V
-
K
----
Q
-
G
K
I
R
V
I
S
I
D
P
V
V
T
K
T
Q
A
Y
-----
L
G
--------
C
--------
E
Q
L
Y
V
N
P
Q
T
D
V
T
L
M
L
A
I
A
H
E
M
I
S
K
------
K
L
Y
D
D
K
F
I
Q
G
Y
S
L
----------------------------------------------------------------------
G
---------
F
-------------------------------------------------------------------------------------------------
E
E
---------
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
V
-
M
GTKDGV
A
K
T
P
E
W
A
A
P
I
C
G
V
E
A
H
V
I
R
D
L
A
K
T
L
------
V
K
G
-------------
R
T
Q
F
-
M
M
G
W
C
I
-
Q
R
Q
Q
H
G
E
Q
P
Y
W
M
A
A
V
L
A
T
M
I
G
Q
I
G
L
P
G
-------
G
G
I
---
S
Y
-----------------
G
H
H
Y
-------
S
-
S
I
------
G
V
--
P
S-
S
------
G
--------
A
---------------------------
A
-
A
-----
P
--
G
--------
A
-----
F
P
-----------------
R
NLDENQKPLFDSSDFKG
A
---
S
---
S
----
T
----------
I
--
P
----
V
----------
A
-----------------------
R
------
W
------------
I
D
A
--------------------------
I
L
EPG
K
T
I
D
A
NG
S
K
----------
V
-
V
Y
P
D
--
I
K
M
M
I
F
S
G
N
N
P
W
N
H
H
Q
D
R
N
R
----
M
------------------------------
K
--
Q
A
-------------------------------
F
-
H
----
K
L
-
E
-
C
V
V
T
V
D
V
N
W
T
A
--
T
C
R
F
S
D
I
V
L
P
A
C
T
T
Y
E
R
N
-
D
I
D
V
Y
G
A
Y
A
N
R
G
I
L
A
M
Q
K
M
V
E
P
L
F
D
S
L
S
D
F
E
I
F
T
R
F
A
A
V
L
G
K
E
K
E
---------------
Y
---
T
R
--
N
M
------------------
G
------
E
----------------
M
E
-
W
---
L
E
T
L
-
Y
N
-----------------
E
---
C
----------
K
------
A
-----
A
N
A
G
K
F
-----
E
---------
M
-----------------------------
P
D
F
A
T
F
W
K
Q
---
G
-
Y
-
V
H
F
G
---------
D
G
E
V
W
T
R
H
--------------
A
------
D
F
R
-----
N
D
P
E
I
N
P
L
G
T
P
S
G
L
I
E
I
F
S
R
K
I
D
--
Q
--
F
GYDD
C
K
G
H
P
T
W
M
E
K
TERSHGG-------
P
G
S
D
K
H
P
I
W
L
Q
S
C
--
H
P
D
K
--
R
L
H
S
--
Q
M
--
C
-
E
-
S
R
E
-
Y
-
R
E
T
Y
A
V
N
-
G
R
E
P
V
Y
I
S
P
V
D
A
K
A
R
G
I
K
D
G
D
I
V
R
V
F
N
D
R
G
Q
L
--
L
A
G
A
V
V
S
--
D
N
F
P
K
G
I
V
R
I
H
E
G
A
W
Y
G
P
V
G
K
D
---
G
STEGGAEV
G
A
L
C
-
S
Y
G
D
-
P
N
T
L
T
L
D
---------------
I
-
G
T
S
K
L
A
Q
A
C
--------------
S
A
----------------
Y
T
-
C
L
V
E
F
E
K
Y
Q
G
K
V
------------------
51
HHSearch
74.27
16%
-55
- C3 -
1Q16
4
NARG_ECOLI
A:
[43-1234]
----------
D
K
I
V
R
S
T
H
G
V
N
C
T
--
G
S
C
S
W
K
I
Y
V
K
-----------------------------------------
N
-------------------------------------------
G
-------------------------------------------
L
V
T
W
--
E
T
Q
Q
TDYPRT
R
------
P
D
L
P
-
N
H
-------
E
P
R
G
C
P
R
G
A
S
Y
S
W
Y
-----
L
Y
S
------
A
-----
N
R
L
K
Y
P
M
-
M
R
-----
K
R
L
M
K
M
W
R
E
A
K
A
L
H
SD
P
V
E
A
W
A
S
I
I
E
D
A
D
K
A
K
S
F
K
Q
A
RG
R
G
G
F
V
R
S
S
W
Q
E
V
N
E
L
I
A
A
S
N
V
Y
T
I
K
N
Y
G
P
D
R
V
A
G
F
----
S
-----------------
P
----
I
-
P
A
M
S
M
V
S
Y
A
S
G
A
R
Y
L
-
S
-
L
I
-
G
G
T
--
C
L
S
F
Y
-----
D
W
Y
C
D
L
P
P
--
A
S
P
Q
T
W
G
--
E
Q
T
D
V
----
P
E
S
A
D
W
Y
N
S
S
Y
I
I
A
W
G
S
N
V
P
Q
T
R
T
P
D
A
--------
H
---
F
F
---
T
E
V
----------------
R
----
Y
-
K
G
T
K
T
V
A
V
T
P
D
Y
A
E
I
A
K
------
L
C
--------
D
--------
L
W
L
A
P
K
Q
G
T
D
A
A
M
A
L
A
M
G
H
V
M
L
R
E
FHLDNP
S
Q
Y
F
T
D
Y
V
R
R
Y
T
D
----------------------------------------------------------------------
M
---------
P
-------------------------------------------------------------------------------------------------
M
L
---------
V
M
L
E
E
R
DGYYAAGRMLRAADLVDALGQENNPEW
K
T
V
A
F
N
TNG
E
M
V
A
P
N
GS
I
G
F
R
W
GEKGKWNLEQRDGKTG
E
E
T
E
L
Q
L
S
LLGSQD
E
I
A
E
V
G
F
P
Y
FGGDGTEH
F
N
K
V
E
L
E
N
V
L
L
H
K
L
P
V
K
R
L
Q
L
ADG
S
T
A
L
V
T
T
V
Y
D
L
T
L
A
N
Y
GLERGLNDVNCATSY
D
D
V
-
K
------
A
Y
T
P
A
W
A
E
Q
I
T
G
V
S
R
S
Q
I
I
R
I
A
R
E
F
------
A
D
N
A
D
K
T
H-
G
------
R
S
M
I
-
I
V
G
A
G
L
-
N
H
W
Y
H
L
D
M
N
Y
R
G
L
I
N
M
L
I
F
C
G
C
V
G
Q
S
G
-------
G
G
W
---
A
H
-----------------
Y
V
G
Q
-------
E
K
L
R
------
P
Q
T-
G
--
W
------
Q
P
L
A
F
ALDW
Q
RP
A
R
H
M
N
S
T
S
Y
F
Y
N
HSSQWRYETV
T
--
A
-
E
-----
E
--
L
L-------
S
-----
P
MADKSR
Y
T
G
H
L
I
D
F
N
V
R
A
E
-----------------
R
---
M
---
G
----
W
----------
L
--
P
----
S
----------
A
PQLGTNPLT
I
A
G
E
A
E
K
A
GMN
P
V
D
Y
------
T
------------
V
K
S
--------------------------
L
K
----------
E
GSIRFAAEQPE
N
-
G
K
N
H
--
P
R
N
L
F
I
W
R
S
N
L
L
G
S
S
G
K
G
H
E
F
---
M
------------------------------
L
--
K
Y
LLGTEHGIQGKDLGQQGGVKPEE
V
D
W
Q
DNGL
E
-
G
----
K
L
-
D
-
L
V
V
T
L
D
F
R
L
S
S
--
T
C
L
Y
S
D
I
I
L
P
T
A
T
W
Y
E
K
D
-
D
M
N
T
S
D
--
M
H
P
F
I
H
P
L
S
A
A
V
D
P
A
W
E
A
K
S
D
W
E
I
Y
K
A
I
A
K
K
F
S
E
V
C
V
G
HL
G
K
E
T
D
I
V
T
L
P
IQ
H
DSA
A
E
--
L
A
QPL
D
V
K
---
D
W
----
K
-
K
G
------
E
CDLIPGKTA
P
H
I
M
V
V
E
R
D
-
Y
PA
T
Y
E
R
F
-
T
S
-----------------
I
GP
L
M
E
K
I
GNGGKG
I
A
W
N
----
T
Q
S
E
M
D
L
L
R
K
L
N
-----
Y
TKAEGPAKG
Q
P
M
L
N
T
A
-
I
D
A
A
E
M
I
L
T
L
--
A
P
E
T
N
G
Q
V
A
V
K
A
W
A
A
L
S
E
F
T
--
G
-
R
-
D
-
H
T
HLALNKED
E
K
-
I
R
F
R
D
I
Q
A
Q
P
R
K
I
I
SSP
T
W
S
G
LEDEH
V
S
Y
N
A
G
Y
-
T
N
V
H
E
L
I
P
W
R
T
L
S
G
R
Q
Q
L
Y
Q
D
H
Q
W
--
M
R
D
F
----
G
E
S
L
L
V
Y
R
P
P
IDTRSVKEVIGQKS
N
G
N
Q
E
K
A
L
N
F
L
T
P
--
H
Q
K
W
--
G
I
H
S
--
T
Y
--
S
-
D
N
L
L
M
-
L
-
T
L
---
G
R
-
G
G
P
V
V
W
L
S
E
A
D
A
K
D
L
G
I
A
D
N
D
W
I
E
V
F
N
S
N
G
A
L
--
T
A
R
A
V
V
S
--
Q
R
V
P
A
G
M
T
M
M
Y
H
A
Q
E
R
I
V
N
L
P
G
S--
E
--------
I
T
Q
Q
-
R
G
G
I
-
H
N
S
V
T
R
I
-----------------
T
P
K
P
T
H
M
I
G
--------------
G
Y
AHLAYGFNYYGTVGSN
R
D
-
E
F
V
V
V
R
K
M
--
K
N
I
D
W
L
--------------
9
PsiBlast_PDB
73.26
24%
-89
- C3 -
2NAP
5
NAPA_DESDA
A:
[8-467]
------------
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
A
V
A
--
I
Q
G
-------
N
------
P
N
N
--
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
-----
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
R
-----
H
K
-------------------------------------
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
SGQCL
T
E
E
S
Y
V
A
N
K
I
F
K
G
----
G
-
F
G
T
N
N
V
D
G
N
P
R
L
C
M
A
-
S
-
A
V
-
G
G
---
Y
V
T
S
F
-----
G
K
D
E
P
M
G
----------------------
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
--
T
S
E
A
H
P
----------
V
--
L
F
---
R
R
I
--------------
A
-
R
R
K
Q
V
E
-
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
---------
M
-------------------------------------------------------------------------------------------------
D
A
EGKPSD
F
E
G
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
-
E
------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
-------
A
T
S
---
F
S
L
T
GQPNACGGVRDGGAL
S
H
L
L
-------
P
-
A
G
------
R
A
--
I
--
P
------
N
--------
A
------------------------
K
--
H
-
R
-----
A
--
E
--------
M
-----
E
------------------
K
-----------------
L
---
W
---
G
----
L
----------
P
--
E
----
G
----------
R
-----------------------
I
------
A
------------
P
E
P
GYH
T
V
---------------------
A
L
----------
F
-----------
E
-
A
L
G
R
GD
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
----
V
------------------------------
H
--
K
A
-------------------------------
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.70
24%
-89
- C3 -
2V45
6
NAPA_DESDA
A:
[8-467]
------------
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
A
V
A
--
I
Q
G
-------
N
------
P
N
N
--
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
-----
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
R
-----
H
K
-------------------------------------
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
SGQCL
T
E
E
S
Y
V
A
N
K
I
F
K
G
----
G
-
F
G
T
N
N
V
D
G
N
P
R
L
C
M
A
-
S
-
A
V
-
G
G
---
Y
V
T
S
F
-----
G
K
D
E
P
M
G
----------------------
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
--
T
S
E
A
H
P
----------
V
--
L
F
---
R
R
I
--------------
A
-
R
R
K
Q
V
E
-
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
---------
M
-------------------------------------------------------------------------------------------------
D
A
EGKPSD
F
E
G
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
-
E
------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
-------
A
T
S
---
F
S
L
T
G
Q
PNACGGVRDGGAL
S
H
L
L
-------
P
-
A
G
------
R
A
--
I
--
P
------
N
--------
A
------------------------
K
--
H
-
R
-----
A
--
E
--------
M
-----
E
------------------
K
-----------------
L
---
W
---
G
----
L
----------
P
--
E
----
G
----------
R
-----------------------
I
------
A
------------
P
E
P
GYH
T
V
---------------------
A
L
----------
F
-----------
E
-
A
L
G
R
GD
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
----
V
------------------------------
H
--
K
A
-------------------------------
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.57
24%
-88
- C3 -
2JIO
5
NAPA_DESDA
A:
[8-467]
------------
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
A
V
A
--
I
Q
G
-------
D
------
P
N
N
--
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
-----
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
R
-----
H
K
-------------------------------------
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
GQCL
T
E
E
S
Y
V
A
N
K
I
F
K
G
----
G
-
F
G
T
N
N
V
D
G
N
P
R
L
C
M
A
-
S
-
A
V
-
G
G
---
Y
V
T
S
F
-----
G
K
D
E
P
M
G
----------------------
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
--
T
S
E
A
H
P
----------
V
--
L
F
---
R
R
I
--------------
A
-
R
R
K
Q
V
E
-
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
---------
M
-------------------------------------------------------------------------------------------------
D
A
EG
K
P
S
D
F
E
G
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
-
E
------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
-------
A
T
S
---
F
S
L
T
GQPNACGGVRDGGAL
S
H
L
L
-------
P
-
A
G
------
R
A
--
I
--
P
------
N
--------
A
------------------------
K
--
H
-
R
-----
A
--
E
--------
M
-----
E
------------------
K
-----------------
L
---
W
---
G
----
L
----------
P
--
E
----
G
----------
R
-----------------------
I
------
A
------------
P
E
P
GYH
T
V
---------------------
A
L
----------
F
-----------
E
-
A
L
G
R
GD
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
----
V
------------------------------
H
--
K
A
-------------------------------
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.27
24%
-90
- C3 -
2JIR
5
NAPA_DESDA
A:
[8-467]
------------
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
A
V
A
--
I
Q
G
-------
N
------
P
N
N
--
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
-----
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
R
-----
H
K
-------------------------------------
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
SGQCL
T
E
E
S
Y
V
A
N
K
I
F
K
G
----
G
-
F
G
T
N
N
V
D
G
N
P
R
L
C
M
A
-
S
-
A
V
-
G
G
---
Y
V
T
S
F
-----
G
K
D
E
P
M
G
----------------------
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
--
T
S
E
A
H
P
----------
V
--
L
F
---
R
R
I
--------------
A
-
R
R
K
Q
V
E
-
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
---------
M
-------------------------------------------------------------------------------------------------
D
A
EGKPSD
F
E
G
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
-
E
------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
-------
A
T
S
---
F
S
L
T
GQPNACGGVRDGGAL
S
H
L
L
-------
P
-
A
G
------
R
A
--
I
--
P
------
N
--------
A
------------------------
K
--
H
-
R
-----
A
--
E
--------
M
-----
E
------------------
K
-----------------
L
---
W
---
G
----
L
----------
P
--
E
----
G
----------
R
-----------------------
I
------
A
------------
P
E
P
GYH
T
V
---------------------
A
L
----------
F
-----------
E
-
A
L
G
R
GD
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
----
V
------------------------------
H
--
K
A
-------------------------------
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.14
24%
-87
- C3 -
2JIM
5
NAPA_DESDA
A:
[8-467]
------------
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
A
V
A
--
I
Q
G
-------
N
------
P
N
N
--
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
-----
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
R
-----
H
K
-------------------------------------
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
GQCL
T
E
E
S
Y
V
A
N
K
I
F
K
G
----
G
-
F
G
T
N
N
V
D
G
N
P
R
L
C
M
A
-
S
-
A
V
-
G
G
---
Y
V
T
S
F
-----
G
K
D
E
P
M
G
----------------------
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
--
T
S
E
A
H
P
----------
V
--
L
F
---
R
R
I
--------------
A
-
R
R
K
Q
V
E
-
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
---------
M
-------------------------------------------------------------------------------------------------
D
A
EG
K
P
S
D
F
E
G
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
-
E
------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
-------
A
T
S
---
F
S
L
T
G
Q
PNACGGVRDGGAL
S
H
L
L
-------
P
-
A
G
------
R
A
--
I
--
P
------
N
--------
A
------------------------
K
--
H
-
R
-----
A
--
E
--------
M
-----
E
------------------
K
-----------------
L
---
W
---
G
----
L
----------
P
--
E
----
G
----------
R
-----------------------
I
------
A
------------
P
E
P
GYH
T
V
---------------------
A
L
----------
F
-----------
E
-
A
L
G
R
GD
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
----
V
------------------------------
H
--
K
A
-------------------------------
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.12
24%
-89
- C3 -
2V3V
9
NAPA_DESDA
A:
[8-467]
------------
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
A
V
A
--
I
Q
G
-------
D
------
P
N
N
--
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
-----
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
R
-----
H
K
-------------------------------------
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
SGQCL
T
E
E
S
Y
V
A
N
K
I
F
K
G
----
G
-
F
G
T
N
N
V
D
G
N
P
R
L
C
M
A
-
S
-
A
V
-
G
G
---
Y
V
T
S
F
-----
G
K
D
E
P
M
G
----------------------
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
--
T
S
E
A
H
P
----------
V
--
L
F
---
R
R
I
--------------
A
-
R
R
K
Q
V
E
-
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
---------
M
-------------------------------------------------------------------------------------------------
D
A
EGKPSD
F
E
G
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
-
E
------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
-------
A
T
S
---
F
S
L
T
G
Q
PNACGGVRDGGAL
S
H
L
L
-------
P
-
A
G
------
R
A
--
I
--
P
------
N
--------
A
------------------------
K
--
H
-
R
-----
A
--
E
--------
M
-----
E
------------------
K
-----------------
L
---
W
---
G
----
L
----------
P
--
E
----
G
----------
R
-----------------------
I
------
A
------------
P
E
P
GYH
T
V
---------------------
A
L
----------
F
-----------
E
-
A
L
G
R
GD
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
----
V
------------------------------
H
--
K
A
-------------------------------
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.92
24%
-92
- C3 -
2JIP
5
NAPA_DESDA
A:
[8-467]
------------
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
A
V
A
--
I
Q
G
-------
N
------
P
N
N
--
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
-----
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
R
-----
H
K
-------------------------------------
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
GQCL
T
E
E
S
Y
V
A
N
K
I
F
K
G
----
G
-
F
G
T
N
N
V
D
G
N
P
R
L
C
M
A
-
S
-
A
V
-
G
G
---
Y
V
T
S
F
-----
G
K
D
E
P
M
G
----------------------
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
--
T
S
E
A
H
P
----------
V
--
L
F
---
R
R
I
--------------
A
-
R
R
K
Q
V
E
-
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
---------
M
-------------------------------------------------------------------------------------------------
D
A
EGKPSD
F
E
G
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
-
E
------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
-------
A
T
S
---
F
S
L
T
GQPNACGGVRDGGAL
S
H
L
L
-------
P
-
A
G
------
R
A
--
I
--
P
------
N
--------
A
------------------------
K
--
H
-
R
-----
A
--
E
--------
M
-----
E
------------------
K
-----------------
L
---
W
---
G
----
L
----------
P
--
E
----
G
----------
R
-----------------------
I
------
A
------------
P
E
P
GYH
T
V
---------------------
A
L
----------
F
-----------
E
-
A
L
G
R
GD
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
----
V
------------------------------
H
--
K
A
-------------------------------
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.82
24%
-90
- C3 -
2JIQ
11
NAPA_DESDA
A:
[8-467]
------------
W
V
K
G
V
-
C
R
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-------------------------------------------
G
-------------------------------------------
K
A
V
A
--
I
Q
G
-------
D
------
P
N
N
--
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
V
-----
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
R
-----
H
K
-------------------------------------
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
GQCL
T
E
E
S
Y
V
A
N
K
I
F
K
G
----
G
-
F
G
T
N
N
V
D
G
N
P
R
L
C
M
A
-
S
-
A
V
-
G
G
---
Y
V
T
S
F
-----
G
K
D
E
P
M
G
----------------------
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
--
T
S
E
A
H
P
----------
V
--
L
F
---
R
R
I
--------------
A
-
R
R
K
Q
V
E
-
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
----------------------------------------------------------------------
F
---------
M
-------------------------------------------------------------------------------------------------
D
A
EGKPSD
F
E
G
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
-
E
------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
-------
A
T
S
---
F
S
L
T
GQPNACGGVRDGGAL
S
H
L
L
-------
P
-
A
G
------
R
A
--
I
--
P
------
N
--------
A
------------------------
K
--
H
-
R
-----
A
--
E
--------
M
-----
E
------------------
K
-----------------
L
---
W
---
G
----
L
----------
P
--
E
----
G
----------
R
-----------------------
I
------
A
------------
P
E
P
GYH
T
V
---------------------
A
L
----------
F
-----------
E
-
A
L
G
R
GD
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
----
V
------------------------------
H
--
K
A
-------------------------------
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------