@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0202c: (2016-04-20 )
MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPGRQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240....----...250.......260.-.-......270...-----....280.......290......---.---300..-.....310.......320.......330.......------340..---...------.---.350.......360.......370.......380.......390..----...-----.---------.---------400.....---..---410...---------------.-------------..--------.-------------------420-----.--........430-.---.--------------------------------------------.---------.-.--------------------------------------------------..-.--------440..-..---------------------------------------------------....--------------------------------------------------450...--..-..460.------.--.-----------------------------------------.---------------------------------.---------------------------------..470.......----------------------------------------------------480--------------------------------------------------..----.----.-------------------------------------------------.---------------------------------------....490.......500---........510.......520.......530.......540.......550.......560.......570...-....580.-......590.......600.......610.......620.-.--.....630.......640.......650.......660-..---.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MM
R
L
S
R
N
L
R
R
C
R
W
L
V
F
T
G
W
L
L
A
L
V
P
A
V
Y
L
A
MTQSGNLTGG
G
F
E
VAGS
Q
S
L
L
V
HDQLDAHYPDRGA
P
A
L
A
L
V
AAPRPDA
S
Y
Q
D
I
D
N
A
V
A
L
L
R
Q
I
A
S
ELPGVTEAPNPTQRPPQPDR
P
Y
V
V
S
L
R
L
DARNA
G
T
S
D
V
A
K
K
L
R
D
RIGVKGDQSGQTAN
G
K
V
R
L
Y
V
I
GQGAL
S
A
A
AAANTKHDIANAERWN
L
P
I
I
L
M
V
L
V
A
V
F
G
S
L
A
A
A
A
I
P
L
A
L
A
V
C
T
V
V
I
T
M
G
L
V
F
V
L
SMH
T
T
M
S
V
F
V
T
S
T
V
S
M
F
G
I
A
L
A
----
V
D
Y
S
L
F
I
L
M
R
Y
R
E
E
L-R-C-GRRPP
D
A
V
D
A
A
M
-----
A
TS
G
L
A
V
V
L
S
G
M
T
V
I
A
S
L
T
G
I
Y
L
---I---N
T
P
A
L
-
R
S
MA
T
G
A
I
L
A
V
A
V
A
M
L
TSATL
T
P
A
V
L
A
T
F
A
R
A
A
A
K
------
R
S
A
L
V
---
H
WS------R---RPAST
Q
S
W
F
W
S
R
W
V
G
W
V
M
RR
P
W
I
T
A
L
A
A
S
T
V
L
L
V
MAA
P
A
T
L
M
V
L
G
N
----
S
L
L
-----
R
---------Q---------FDSSHEIR---T
G
---
A
A
A
A
A
Q
---------------A-------------LG--------P-------------------G-------A--LG
P
V
Q
V
L
V
R
F--D---A--------------------------------------------G---------G-A--------------------------------------------------SA-P--------
E
-
H
S
Q
-
T
I
---------------------------------------------------
A
A
I
R
--------------------------------------------------
H
R
I
AQA--P
N
-
V
V
SVAP------P--R-----------------------------------------F---------------------------------A---------------------------------DDN
G
S
A
L
L
S
A
V
L----------------------------------------------------S----------------------------------------------------V
D
----
P
----
E
-------------------------------------------------D---------------------------------------LGAR
D
T
I
T
W
M
R
TQLPR----VAG
A
A
Q
VDVGG
P
T
A
L
I
K
DF
D
D
RVSAT
Q
P
L
V
L
V
F
V
A
V
I
A
F
L
M
L
L
I
S
I
R
S
V
F
L
A
F
K
G
V
L
M
T
L
L
S
V
A
A
A
YG
S
L
V
M
V
F
-QWGWARGL-G
F
P
A
L
H
S
IDSTV
P
P
L
V
L
A
M
T
FGLSM
D
Y
E
I
F
L
L
T
R
I
R
E
R
F
L
-Q--TGQTRD
A
V
A
YGVRTS
A
R
T
I
T
S
A
A
L
I
M
I
A
V
F
C
G
F
A
FA---G
M
---
P
L
V
A
E
I
G
V
A
C
A
V
A
I
A
V
D
A
T
V
V
R
L
V
L
V
P
A
L
M
A
M
F
DRWN
W
W
L
P
R
W
L
A
H
ILPSVDFDRPLPKVDLG
D
V
V
V
IPD
D
F
AAAIPP
S
A
D
V
R
M
V
L
K
S
A
A
K
L
K
R
LAPD
A
I
C
VTDPL
A
F
TGCGCDG
K
A
L
D
Q
V
Q
L
A
Y
RN
G
I
A
R
A
ISWGQRPV
H
P
V
T
V
W
R
K
R
L
A
V
A
L
D
A
L
QTTTWECGGVQTHRAGPGYRRRSPVETT
N
V
ALPTGDRLQIPTGA
E
T
L
R
F
K
G
Y
L
I
M
SRNSSHDY
A
D
F
A
D
L
V
D
TMA
P
E
T
A
A
A
V
L
A
G
M
D
R
Y
Y
SCQAPG
R
Q
W
M
A
T
Q
L
V
G
RLADPQPSDLGDQSPGAD
A
Q
A
K
W
E
E
V
R
R
R
C
L
S
V
A
V
A
M
L
EEAR
24
HHSearch
91.83
17%
-137
- C2 -
4DX5
9
ACRB_ECOLI
A:
[334-1036]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
---
L
T
M
F
G
M
V
L
A
I
G
L
L
----
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
-
A
-
E
E
G
L
P
P
K
E
A
T
R
K
S
M
-----
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
FGG
S
---
T
G
A
I
Y
-
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
------
G
D
H
G
E
---
G
K
K
G
F
F
G
W
F
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
L
I
I
V
V
G
M
A
Y
L
F
V
R
L
P
S
S
F
----
L
P
D
-----
E
DQG
V
F
M
T
M
V
Q
---------
L
P
A
G
A
T
Q
E
---
R
T
---
Q
K
V
L
N
E
V
T
H
Y
Y
L
TKEKNNVE
S
V
-------------
F
A
V
N
GFGFAG
R
-------------------
G
Q------
N
--
T
G
I
A
F
V
S
L
K
D
--
W
---
A
--------------------------------------------
D
-----------
R
--------------------------------------------------
P
G
-
E
E-------
N
K
V
E
A
-
I
T
M
R
A
T
R
A
F
S
QIKD
A
M
V
F
A
F
N
L
P
AIVELGTAT
G
F
D
F
E
L
I
DQAGLG
H
E
K
L
T
Q
A
R
N
Q
L
L
--------------------------------------------------
A
E
A
A
K
H
--
P
D
M
L
T
S
V
R
P
NGL
E
D
T
P
--
Q
F
K
---------------------------------------
I
D
I
D
Q
E
K
A
Q
A
L
GVS
I
N
D
I
N
T
T
L
G
A
A
WGGSYV
N
D
F
I
---------------------------------
D
R
G
R
V
K
K
V
Y
V
M
S
----------------------------------------------------
E
----------------------------------------------------
A
K
----
Y
RMLP
D
DIGD
W
Y
V
R
A
A---------------------------------------
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
NG
L
P
S
M
E
I
L
G
Q
A
A
PG
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
----
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
----
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
----------
R
-
G
L
T
-
N
D
V
Y
----
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
--
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
---
T
G
AG
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
-
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
S
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
86.99
16%
-139
* C2 *
3W9I
3
MEXB_PSEAE
A:
[320-1030]
----------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
Y
P
Y
D
T
T
---
P
V
V
S
A
S
I
H
E
V
V
K
T
L
G
E
A
I
L
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
G
V
L
A
A
F
G
F
S
I
N
T
---
L
T
M
F
G
M
V
L
A
I
G
L
L
----
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
-
A
E
E
-
G
L
S
P
R
E
A
A
R
K
S
M
-----
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
L
P
M
A
F
FGG
S
---
T
G
V
I
Y
-
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
I
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
--------------------F
F
----
G
W
F
N
R
M
F
L
S
T
T
H
G
Y
E
R
G
V
A
S
I
L
K
H
R
A
P
Y
L
L
I
Y
V
V
I
V
A
G
M
I
W
M
F
T
R
I
P
T
A
F
----
L
P
D
-----
E
---------
D
QG
V
L
F
A
Q
V
Q
T
P
P
G
S
S
A
E
R
T
Q
V
V
---
V
D
S
M
R
E
---------------
Y
-------------
L
L
--------
E
KESSSVS
S
V
F
T
V
T
GFNFAG
R
-------
G
QS
S
G
M
A
F
I
M
L
K
P
--
W
---
E
--------------------------------------------
E
---------
R
P
G
GENSV
F
E
L
A
K
R
A
Q
MHFFSFKDAMV
F
A
F
A
P
P
SVLELGNAT
G
F
D
L
F
L
Q
D
QAG
V
G
H
E
--------
V
-
L
L
Q
-
A
R
---------------------------------------------------
N
K
F
L
--------------------------------------------------
M
L
A
A
Q
N
--
P
A
-
L
Q
R
V
R
P
------
N
--
G
MSD
E
P
Q
Y
K
---------------------------------
L
---------------------------------
E
I
D
D
E
K
A
S
A
L
GVS
L
A
D
I
N
S
T
V
S
I
A
WGSSYV
N
D
F
I
D
R
G
R
V
K
R
V
Y
L
Q
G
----------------------------------------------------
R
----------------------------------------------------
P
D
ARMN
P
----
D
D
L
S
K
W
Y
V
R
N
DKG
E
M
V
P
FNAF
A
T
G
K
W
E
Y
G
S
P
K
L
E
R
Y
NG
V
P
A
M
E
I
L
G
E
P
AP
G
---------------------------------------
L
S
S
G
D
A
M
A
A
V
E
E
I
V
K
Q
----
L
P
K
G
V
G
Y
S
W
T
G
L
S
Y
E
----
E
R
L
S
G
-
Q
A
P
A
L
Y
A
L
S
L
L
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
T
S
M
----------
R
-
G
L
S
-
N
D
V
F
----
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
E
L
H
E
-
Q
--
G
K
G
I
V
E
A
A
I
E
A
C
R
M
R
L
R
P
I
V
M
T
S
L
A
F
I
L
G
V
V
P
L
A
I
S
---
T
G
A
G
S
G
S
Q
H
A
I
G
T
G
V
I
G
G
M
V
T
-
A
T
V
L
A
I
F
W
V
P
L
F
Y
V
A
V
S
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
84.64
14%
-131
- C2 -
4MT1
-
?
A:
[329-1040]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
V
E
I
S
I
E
K
V
I
H
T
L
I
E
A
M
V
L
V
F
V
V
M
Y
L
F
L
Q
N
I
R
Y
T
L
I
P
T
I
V
V
P
I
S
L
L
G
G
F
A
F
I
S
Y
M
G
M
S
I
N
V
---
L
T
M
F
A
M
I
L
V
I
G
I
V
----
V
D
D
A
I
V
V
V
E
N
V
E
R
I
M
-
A
G
E
-
G
L
P
P
K
E
A
T
K
K
A
M
-----
G
Q
I
S
G
A
V
I
G
I
T
A
V
L
I
S
V
F
V
P
L
A
M
---
F
SG
A
A
G
N
I
Y
-
K
Q
F
A
L
T
M
A
S
S
I
A
F
S
A
F
L
A
L
T
L
T
P
A
L
C
A
T
------------------G
F
F
G
W
F
------
N
---
K
K
F
D
S
W
T
H
G
Y
E
G
R
V
A
K
V
L
R
K
T
F
R
M
M
V
V
Y
I
G
L
A
V
V
G
V
F
L
F
M
R
L
P
T
S
F
----
L
P
T
-----
E
DQG
F
V
M
V
S
V
Q
---------
L
P
A
G
A
T
K
E
R
T
D
A
T
---
L
A
Q
V
T
Q
---------------
L
-------------
A
K
--------
S
-------------------
I
P------
E
--
I
E
N
I
I
T
V
S
G
F
SF
S
GSG
Q
--------------------------------------------
N
M
A
M
G
F
A---
I
-
F
--------------------------------------------------
K
D
-
W
NERTASGS
D
-
A
V
A
-
V
A
---------------------------------------------------
G
K
L
T
G
M
M
M
G
TLKD
G
F
G
I
A
V
V
P
P
PILELG
S
G
L
S
I
N
L
Q
D
RNNTG
H
T
A
L
L
A
K
R
N
E
L
I
Q
K
M
R
A
S
GL
F
D
-
P
S
T
V
R
A
G
G
L
E
D
S
P
--
Q
L
K
I
D
I
N
R
A
A
A
A
A
QGIS
F
A
D
I
R
T
A
L
A
S
A
LS
S
S
Y
V
S
D
------
F
---------------------------------
P
---------------------------------
N
Q
G
R
L
Q
R
V
M
V
Q
A
D
EDARMQPADILNLTVPNKSG
V
A
V
P
LSTI
A
T
V
S
W
E
N
G
T
E
Q
S
V
R
F
NG
Y
P
S
M
K
L
S
----------------------------------------------------
A
S
----
P
----
A
T------------------------------------------------
G
---------------------------------------
V
S
T
G
Q
A
M
E
A
V
Q
K
M
V
D
E
----
L
G
G
G
Y
S
F
E
W
G
G
Q
S
S
E
E
A
K
----
G
G
S
Q
T
L
I
L
Y
G
L
A
V
A
A
V
F
L
V
L
A
A
L
Y
E
S
W
S
I
P
L
A
V
I
L
V
I
P
L
G
L
I
G
A
A
A
G
V
T
G
R
N
L
F
E
G
L
L
G
S
V
P
S
F
A
----
N
D
I
-
Y
F
Q
V
G
F
V
T
V
M
G
L
S
A
K
N
A
I
L
I
I
E
F
A
K
D
L
Q
A
-
Q
--
G
K
S
A
V
E
A
A
L
E
A
A
R
L
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
P
L
Y
I
A
AGA
S
S
---
A
S
Q
R
A
I
G
T
T
V
F
W
G
M
L
V
-
G
T
L
L
S
V
F
L
V
P
L
F
Y
V
V
V
R
K
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
79.64
15%
-123
- C2 -
3AQP
-
SECDF_THET8
A:
[252-726]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
K
V
A
E
I
R
A
I
G
P
T
L
G
Q
D
A
I
Q
A
G
I
R
S
A
L
I
G
T
L
A
I
F
L
L
I
F
A
Y
Y
G
-
P
H
L
G
L
V
A
S
L
G
L
L
Y
T
S
A
L
I
L
G
L
L
S
G
L
G
A
T
L
T
L
---
P
G
I
A
G
L
V
L
T
L
G
A
A
----
V
D
G
N
V
L
S
F
E
R
I
K
E
E
L
-
R
-
A
-
G
K
K
L
R
Q
A
I
P
E
G
F
-----
R
H
S
T
L
T
I
M
D
V
N
I
A
H
L
L
A
A
A
A
L
Y
Q
---
Y
---
A
T
G
P
V
-
R
G
F
A
V
I
L
A
I
G
V
V
A
S
V
F
S
N
L
V
F
S
R
H
L
L
E
R
L
A
D
R
G
E
I
------
R
P
P
M
-----
W
---------------
L
V
----
D
P
R
F
N
F
M
G
P
A
R
Y
V
T
-
A
A
T
L
L
L
A
A
L
A
A
G
V
V
F
A
K
G
F
N
Y
------
S
-----
I
--------------------------------------------------------
D
-------------
F
T
--------
G
-------------------
G
-----------
T
A
Y
T
L
R
A
E
P
--
N
---------------------------------------------------------------------------------------------------------------
V
-----------------
E
V
---------------------------------------------------
E
T
L
R
--------------------------------------------------
R
F
L
E
E
K
--
G
F
-
P
G
K
E
A
V
------
I
T
Q
V
-----------------------------------------------------------------------------------------------------------------
Y
R
E
F
L
V
K
----------------------------------------------------------------------------------------------------------
L
P
----
P
----
L
-------------------------------------------------
S
---------------------------------------
D
---
E
R
R
L
E
L
E
R
L
F
A
S
-------
E
L
K
A
T
V
L
A
S
E
T
V
G
P
A
I
G
E
E
L
R
R
N
A
V
M
A
V
L
V
G
L
G
L
I
L
L
Y
V
A
F
R
F
-
D
W
T
F
G
V
A
S
I
L
A
V
A
H
D
V
A
I
V
A
G
M
Y
S
L
----------
L
-
G
L
E
-
F
S
I
P
T
----
I
A
A
L
L
T
I
V
G
Y
S
I
N
D
S
I
V
V
S
D
R
I
R
E
N
Q
K
-
L
LR
H
L
P
Y
A
E
L
V
N
R
S
I
N
Q
T
L
S
R
T
V
M
T
S
L
T
T
L
L
P
I
L
A
L
L
F
L
---
G
G
---
S
V
L
R
D
F
A
L
A
I
F
V
G
I
F
V
-
G
T
Y
S
S
I
Y
V
V
S
A
L
V
V
A
W
K
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
75.34
14%
-138
- C2 -
4K0J
1
?
A:
[314-1018]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
K
V
V
P
Y
I
D
R
---
S
N
L
V
D
A
T
V
H
T
V
G
K
T
L
M
E
G
M
F
L
V
S
L
V
L
L
L
F
L
G
S
P
R
A
A
I
I
V
A
V
T
I
P
L
S
L
L
M
A
F
I
L
M
H
H
F
K
I
P
A
N
L
L
---
S
-
L
-
G
A
I
D
F
G
I
I
----
V
D
G
A
I
V
V
M
E
N
I
L
R
R
R
-----------
D
I
M
Q
S
V
-----
L
Q
V
A
R
P
I
F
F
G
M
I
V
I
I
T
A
Y
L
P
L
F
A
FQR
I
---
E
Y
K
L
F
-
S
P
M
A
F
A
V
G
F
A
L
F
G
A
L
L
V
A
L
L
L
I
P
G
L
A
-------------------------------------
A
L
V
W
L
A
P
R
Y
E
S
V
L
N
R
---
S
T
R
T
A
I
G
I
A
V
A
T
L
V
G
V
M
I
L
G
A
T
I
G
R
D
F
LPYL
D
E
G
S
I
W
L
Q
V
---------
T
---------
L
P
P
G
I
S
L
E
---
K
A
G
Q
M
A
D
N
L
R
A
---------------
A
T
M
EFPEVE
H
V
V
T
Q
V
G
--------
R
-------------------
N
DEGTDPF
S
--
P
S
H
I
E
T
A
V
T
L
--
H
---
P
YSTWTSGRD
K
Q
Q
L
I
E
A
M
A
T
R
F
R
D
LPG
T
Q
V
G
F
S
Q
P
M
I
D
G
V
L
D
K
L
A
G
AHSD
L
V
V
K
V
Y
-
G
--------------------------------------------------
N
D
-
F
--------
A
-
E
T
R
Q
V
A
---------------------------------------------------
T
A
I
T
--------------------------------------------------
R
L
L
K
T
V
--
P
G
-
A
Q
D
V
I
I
------
D
--
Q
E
P
P
L
P
Q
V
R
I
D
V
D
R
A
A
A
A
R
L
GIN
V
A
D
V
M
A
L
I
Q
T
G
IGGSPV
T
Q
V
---------------------------------
F
---------------------------------
V
E
D
R
S
Y
N
V
V
A
R
F
----------------------------------------------------
I
GSSRND
P
E
A
I
G
N
L
T
L
T
A
ANG
A
H
V
A
LAQV
A
H
I
R
L
A
E
G
E
TTITREMN
K
R
H
L
T
V
R
L
N
----
L
----
R
-------------------------------------------------
G
---------------------------------------
R
D
L
S
T
F
L
E
E
A
R
M
R
I
D
K
EVPY
D
R
T
H
I
Q
V
A
W
G
G
Q
F
----
E
N
Q
Q
R
A
Q
A
R
L
A
V
I
L
P
M
V
L
A
L
M
F
V
L
L
F
-------
Q
P
A
L
I
L
M
A
V
P
L
A
T
L
G
G
L
V
A
L
H
L
----------
R
-
G
M
T
-
L
N
V
S
----
S
A
V
G
F
I
A
L
F
G
V
A
V
L
N
A
I
I
M
I
A
N
L
-------------
K
E
A
V
V
R
G
A
G
E
R
M
R
P
V
L
M
T
A
T
V
A
A
L
G
L
I
P
A
A
L
A
HGL
G
S
---
D
V
Q
R
P
L
A
T
V
V
V
G
G
L
I
T
-
A
T
A
L
T
L
V
L
L
P
A
L
Y
Y
L
I
E
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
64.57
100%
-39
- C2 -
4Y0L
10
A:
[1-88]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
Q
V
L
V
R
F
--
D
---
A
--------------------------------------------
G
---------
G
-
A
--------------------------------------------------
S
A
-
P
--------
E
-
H
S
Q
-
T
I
---------------------------------------------------
A
A
I
R
--------------------------------------------------
H
R
I
A
Q
A
--
P
N
-
V
V
S
V
A
P
------
P
--
R
-----------------------------------------
F
---------------------------------
A
---------------------------------
D
D
N
G
S
A
L
L
S
A
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
T
I
T
W
M
R
T
Q
L
P
R
----
V
A
G
A
A
Q
V
D
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.57
100%
-39
- C2 -
4Y0L
10
A:
[1-88]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
Q
V
L
V
R
F
--
D
---
A
--------------------------------------------
G
---------
G
-
A
--------------------------------------------------
S
A
-
P
--------
E
-
H
S
Q
-
T
I
---------------------------------------------------
A
A
I
R
--------------------------------------------------
H
R
I
A
Q
A
--
P
N
-
V
V
S
V
A
P
------
P
--
R
-----------------------------------------
F
---------------------------------
A
---------------------------------
D
D
N
G
S
A
L
L
S
A
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
T
I
T
W
M
R
T
Q
L
P
R
----
V
A
G
A
A
Q
V
D
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
62.18
100%
-32
- C2 -
4Y0L
10
A:
[1-85]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
Q
V
L
V
R
F
--
D
---
A
--------------------------------------------
G
---------
G
-
A
--------------------------------------------------
S
A
-
P
--------
E
-
H
S
Q
-
T
I
---------------------------------------------------
A
A
I
R
--------------------------------------------------
H
R
I
A
Q
A
--
P
N
-
V
V
S
V
A
P
------
P
--
R
-----------------------------------------
F
---------------------------------
A
---------------------------------
D
D
N
G
S
A
L
L
S
A
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
T
I
T
W
M
R
T
Q
L
P
R
----
V
A
G
A
A
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
55.21
23%
-89
- C2 -
4DX6
3
ACRB_ECOLI
A:
[338-536]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
GDHGEG
K
K
G
F
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
54.90
23%
-92
- C2 -
4DX7
3
ACRB_ECOLI
A:
[338-536]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
GDHGEG
K
K
G
F
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
54.40
23%
-92
- C2 -
4DX5
4
ACRB_ECOLI
A:
[338-536]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
GDHGEG
K
K
G
F
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
54.37
23%
-96
- C2 -
2J8S
4
ACRB_ECOLI
A:
[338-536]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
GDHGEG
K
K
G
F
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
53.92
23%
-93
- C2 -
4U8Y
2
ACRB_ECOLI
A:
[338-536]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
N
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
GDHGEG
K
K
G
F
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
53.83
23%
-93
- C2 -
1OYD
-
ACRB_ECOLI
A:
[338-546]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
GLL
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
--------------
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
53.82
23%
-89
- C2 -
2RDD
2
ACRB_ECOLI
A:
[338-545]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
GQI
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
-------
K
G
F
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
53.25
23%
-97
- C2 -
1OY6
-
ACRB_ECOLI
A:
[338-546]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
GL
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
--------------
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
53.09
23%
-90
- C2 -
4CDI
-
ACRB_ECOLI
A:
[338-541]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
GDHGEG
K
K
G
F
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
52.85
23%
-91
- C2 -
4C48
2
ACRB_ECOLI
A:
[338-541]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
GDHGEG
K
K
G
F
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
52.69
23%
-94
- C2 -
2GIF
-
ACRB_ECOLI
A:
[338-536]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
QI
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
GDHGEG
K
K
G
F
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
52.45
23%
-95
- C2 -
1OY9
1
ACRB_ECOLI
A:
[338-546]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
---
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
----
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
GLL
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
-
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
------
G
---
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
--------------
F
---
G
W
F
------
N
---
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------