@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0234c: (2016-04-20 )
MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPAKDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQTSFAQRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYAENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSGAVEAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRPGWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFGLGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRELSAHGIREFCNIKTVWIA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.....-...90--....-.....100.......110.......120.......130....----...140.......150.......-160.......170.......180.......190.......200.......210.......220.......230.......240........250.......260.......270.....-..280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRSV
T
C
S
A
T
L
V
L
P
VIEPTPADRRP
R
H
L
L
LGSAGHVSGRLDTG
R
F
V
QTHPAKDVS
V
P
I
A
TINPATG
E
T
V
K
T
F
TAATD
D
E
V
D
A
A
I
A
R
A
-
H
R
R
F
---
A
D
Y
R
-
Q
T
S
F
A
Q
R
A
R
WAN
A
T
A
D
L
L
E
A
E
A
D
Q
A
A
A
M
M
T
L
EMG
K
T
L
A
A
A
K
A
----
E
A
L
K
C
A
K
G
F
R
Y
Y
AEN
A
E
A
LLADE-PA
D
A
A
KVGASAAYGRYQP
L
G
V
I
L
A
VMPWN
F
P
L
W
Q
A
V
R
F
A
A
P
A
L
MAGNV
G
L
L
KHASN
V
P
Q
C
A
L
Y
L
A
D
V
I
ARGGF
P
D
G
C
F
Q
T
L
L
-VSS
G
A
V
E
A
I
LRDP
R
V
A
A
A
TLTGSEPAGQSVGAIAGN-EIK
P
T
V
L
ELGGSD
P
F
I
V
MPSA
D
L
D
A
A
V
S
T
A
V
T
G
R
VQNN
G
Q
S
C
I
A
A
K
R
F
I
V
H
A
D
I
Y
D
D
F
V
D
K
F
V
A
R
M
A
A
LRVGDPTDPDTDVGPL
A
T
E
Q
G
R
N
E
V
A
K
Q
V
E
D
A
A
AA
G
A
V
I
RCGGKRLDRPGWFYP
P
T
V
I
T
D
I
S
K
D
M
A
L
Y
T
E
E
V
F
G
P
V
A
S
V
F
R
AA
N
I
D
E
A
V
E
IAN
A
T
TFGLGSNAWTR
D
E
T
E
Q
R
R
F
I
D
D
I
VAG
Q
V
F
IN
G
M
TVSYPELPFGGVKRSGYGRE
L
S
A
H
G
I
R
E
F
CN
I
K
T
V
W
IA
22
PsiBlast_CBE
99.50
56%
-84
- C3 -
4ITA
11
?
B:
[5-455]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
----
Y
T
E
T
Q
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
C
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
S
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
1
PsiBlast_PDB
99.36
56%
-85
- C3 -
4IT9
18
?
A:
[5-455]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
----
Y
T
E
T
Q
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
C
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
S
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
23
PsiBlast_CBE
99.33
56%
-85
- C3 -
4IT9
10
?
B:
[5-455]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
----
Y
T
E
T
Q
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
C
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
S
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
24
PsiBlast_CBE
99.30
56%
-86
- C3 -
3VZ3
2
?
B:
[6-456]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
----
Y
T
E
T
Q
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
A
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
S
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
6
PsiBlast_PDB
99.30
56%
-87
- C3 -
3VZ3
2
?
A:
[6-456]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
----
Y
T
E
T
Q
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
A
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
S
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
2
PsiBlast_PDB
99.07
56%
-85
- C3 -
4ITA
18
?
A:
[5-455]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
----
Y
T
E
T
Q
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
C
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
S
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
4
PsiBlast_PDB
98.99
56%
-87
- C3 -
3VZ1
-
?
A:
[3-453]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
----
Y
T
E
T
Q
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
C
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
S
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
21
PsiBlast_CBE
98.91
56%
-83
- C3 -
4ITB
14
?
B:
[5-455]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
----
Y
T
E
T
Q
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
C
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
S
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
3
PsiBlast_PDB
98.91
56%
-84
- C3 -
4ITB
17
?
A:
[5-455]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
----
Y
T
E
T
Q
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
C
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
S
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
5
PsiBlast_PDB
98.37
56%
-86
- C3 -
3VZ2
-
?
A:
[3-453]
--------------------------------------------------------
I
A
T
I
N
P
T
T
G
E
I
C
Q
R
F
K
A
L
T
P
A
E
I
D
A
K
L
A
K
A
-
Q
E
A
F
---
Q
A
Y
R
-
R
T
S
F
S
Q
R
R
Q
W
L
E
N
A
A
A
I
L
E
R
D
T
S
K
F
A
E
I
M
T
T
E
M
G
K
T
H
Q
S
A
I
A
----
E
A
E
K
S
A
L
V
C
R
Y
Y
A
E
H
G
E
Q
F
L
A
N
E
-
Y
T
E
T
Q
---
A
T
E
S
Y
V
C
Y
Q
P
L
G
I
L
L
A
V
M
P
W
N
F
P
F
W
Q
V
F
R
F
A
A
P
A
L
M
A
G
N
V
A
V
L
K
H
A
S
N
V
P
Q
C
A
L
A
V
E
A
I
L
E
A
A
G
F
P
E
G
V
F
Q
T
L
L
-
I
G
A
S
Q
V
E
Q
V
I
K
D
P
R
V
K
A
A
T
L
T
G
S
E
P
A
G
A
S
L
A
S
L
A
G
Q
-
E
I
K
P
T
L
L
E
L
G
G
S
D
P
F
V
V
F
P
S
A
D
L
D
E
A
V
E
V
G
T
V
A
R
T
M
N
N
G
Q
S
C
I
A
A
K
R
F
I
L
H
E
A
I
A
A
E
F
L
E
K
L
H
L
K
F
A
S
L
K
I
G
D
P
M
A
P
E
T
D
I
G
P
L
A
T
E
G
I
L
Q
D
I
S
R
Q
V
D
Q
A
V
A
A
G
A
K
I
L
L
G
G
R
P
L
D
R
A
G
Y
F
Y
P
P
T
I
L
T
E
I
P
P
G
A
K
I
L
Q
E
E
L
F
A
P
V
A
M
V
F
T
V
K
D
L
D
Q
A
I
A
L
A
N
D
I
P
F
G
L
G
A
S
A
W
T
N
D
P
A
E
Q
Q
R
F
I
Q
E
L
D
A
G
A
V
F
I
N
G
M
V
K
A
D
P
R
L
P
F
G
G
T
K
R
S
G
Y
G
R
E
L
G
L
A
G
I
R
T
F
V
N
A
K
T
V
W
L
-
10
PsiBlast_PDB
89.89
37%
-77
- C3 -
4OGD
-
?
A:
[5-454]
----------------------------------------------------------
T
I
Y
P
Y
T
N
E
V
L
H
T
F
D
N
M
T
D
Q
G
L
A
D
V
L
E
R
A
-
H
L
L
Y
---
K
K
W
R
K
E
D
H
L
E
E
R
K
A
Q
L
H
Q
V
A
N
I
L
R
R
D
R
D
K
Y
A
E
I
M
T
K
D
M
G
K
L
F
T
E
A
Q
G
----
E
V
D
L
C
A
D
I
A
D
Y
Y
A
D
K
A
D
E
F
L
M
S
T
-
P
L
E
---
T
D
S
G
Q
A
Y
Y
L
K
Q
S
T
G
V
I
L
A
V
E
P
W
N
F
P
Y
Y
Q
I
M
R
V
F
A
P
N
F
I
V
G
N
P
M
V
L
K
H
A
S
I
C
P
R
S
A
Q
S
F
E
E
L
V
L
E
A
G
A
E
A
G
S
I
T
N
L
F
-
I
S
Y
D
Q
V
S
Q
V
I
A
D
K
R
V
V
G
V
C
L
T
G
S
E
R
G
G
A
S
I
A
E
E
A
G
K
-
N
L
K
K
T
T
L
E
L
G
G
D
D
A
F
I
I
L
D
D
A
D
W
D
Q
L
E
K
V
L
Y
F
S
R
L
Y
N
A
G
Q
V
C
T
S
S
K
R
F
I
V
L
D
K
D
Y
D
R
F
K
E
L
L
T
K
V
F
K
T
A
K
W
G
D
P
M
D
P
E
T
T
L
A
P
L
S
S
A
Q
A
K
A
D
V
L
D
Q
I
K
L
A
L
D
H
G
A
E
L
V
Y
G
G
E
A
I
D
H
P
G
H
F
V
M
P
T
I
I
A
G
L
T
K
D
N
P
I
Y
Y
Q
E
I
F
G
P
V
G
E
I
Y
K
V
S
S
E
E
E
A
I
E
V
A
N
D
S
N
Y
G
L
G
G
T
I
F
S
S
N
Q
E
H
A
K
A
V
A
A
K
I
E
T
G
M
S
F
I
N
S
G
W
T
S
L
P
E
L
P
F
G
G
I
K
H
S
G
Y
G
R
E
L
S
E
L
G
F
T
S
F
V
N
E
H
L
I
Y
I
-
27
PsiBlast_CBE
89.73
37%
-76
- C3 -
4OHT
1
?
B:
[5-454]
----------------------------------------------------------
T
I
Y
P
Y
T
N
E
V
L
H
T
F
D
N
M
T
D
Q
G
L
A
D
V
L
E
R
A
-
H
L
L
Y
---
K
K
W
R
K
E
D
H
L
E
E
R
K
A
Q
L
H
Q
V
A
N
I
L
R
R
D
R
D
K
Y
A
E
I
M
T
K
D
M
G
K
L
F
T
E
A
Q
G
----
E
V
D
L
C
A
D
I
A
D
Y
Y
A
D
K
A
D
E
F
L
M
S
T
-
P
L
E
---
T
D
S
G
Q
A
Y
Y
L
K
Q
S
T
G
V
I
L
A
V
E
P
W
N
F
P
Y
Y
Q
I
M
R
V
F
A
P
N
F
I
V
G
N
P
M
V
L
K
H
A
S
I
C
P
R
S
A
Q
S
F
E
E
L
V
L
E
A
G
A
E
A
G
S
I
T
N
L
F
-
I
S
Y
D
Q
V
S
Q
V
I
A
D
K
R
V
V
G
V
C
L
T
G
S
E
R
G
G
A
S
I
A
E
E
A
G
K
-
N
L
K
K
T
T
L
E
L
G
G
D
D
A
F
I
I
L
D
D
A
D
W
D
Q
L
E
K
V
L
Y
F
S
R
L
Y
N
A
G
Q
V
C
T
S
S
K
R
F
I
V
L
D
K
D
Y
D
R
F
K
E
L
L
T
K
V
F
K
T
A
K
W
G
D
P
M
D
P
E
T
T
L
A
P
L
S
S
A
Q
A
K
A
D
V
L
D
Q
I
K
L
A
L
D
H
G
A
E
L
V
Y
G
G
E
A
I
D
H
P
G
H
F
V
M
P
T
I
I
A
G
L
T
K
D
N
P
I
Y
Y
Q
E
I
F
G
P
V
G
E
I
Y
K
V
S
S
E
E
E
A
I
E
V
A
N
D
S
N
Y
G
L
G
G
T
I
F
S
S
N
Q
E
H
A
K
A
V
A
A
K
I
E
T
G
M
S
F
I
N
S
G
W
T
S
L
P
E
L
P
F
G
G
I
K
H
S
G
Y
G
R
E
L
S
E
L
G
F
T
S
F
V
N
E
H
L
I
Y
I
-
26
PsiBlast_CBE
89.70
37%
-78
- C3 -
4YWU
3
?
B:
[5-454]
----------------------------------------------------------
T
I
Y
P
Y
T
N
E
V
L
H
T
F
D
N
M
T
D
Q
G
L
A
D
V
L
E
R
A
-
H
L
L
Y
---
K
K
W
R
K
E
D
H
L
E
E
R
K
A
Q
L
H
Q
V
A
N
I
L
R
R
D
R
D
K
Y
A
E
I
M
T
K
D
M
G
K
L
F
T
E
A
Q
G
----
E
V
D
L
C
A
D
I
A
D
Y
Y
A
D
K
A
D
E
F
L
M
S
T
-
P
L
E
---
T
D
S
G
Q
A
Y
Y
L
K
Q
S
T
G
V
I
L
A
V
E
P
W
N
F
P
Y
Y
Q
I
M
R
V
F
A
P
N
F
I
V
G
N
P
M
V
L
K
H
A
S
I
C
P
R
S
A
Q
S
F
E
E
L
V
L
E
A
G
A
E
A
G
S
I
T
N
L
F
-
I
S
Y
D
Q
V
S
Q
V
I
A
D
K
R
V
V
G
V
C
L
T
G
S
E
R
G
G
A
S
I
A
E
E
A
G
K
-
N
L
K
K
T
T
L
E
L
G
G
D
D
A
F
I
I
L
D
D
A
D
W
D
Q
L
E
K
V
L
Y
F
S
R
L
Y
N
A
G
Q
V
C
T
S
S
K
R
F
I
V
L
D
K
D
Y
D
R
F
K
E
L
L
T
K
V
F
K
T
A
K
W
G
D
P
M
D
P
E
T
T
L
A
P
L
S
S
A
Q
A
K
A
D
V
L
D
Q
I
K
L
A
L
D
H
G
A
E
L
V
Y
G
G
E
A
I
D
H
P
G
H
F
V
M
P
T
I
I
A
G
L
T
K
D
N
P
I
Y
Y
Q
E
I
F
G
P
V
G
E
I
Y
K
V
S
S
E
E
E
A
I
E
V
A
N
D
S
N
Y
G
L
G
G
T
I
F
S
S
N
Q
E
H
A
K
A
V
A
A
K
I
E
T
G
M
S
F
I
N
S
G
W
T
S
L
P
E
L
P
F
G
G
I
K
H
S
G
Y
G
R
E
L
S
E
L
G
F
T
S
F
V
N
E
H
L
I
Y
I
-
25
PsiBlast_CBE
89.67
37%
-77
- C3 -
4YWV
3
?
B:
[5-454]
----------------------------------------------------------
T
I
Y
P
Y
T
N
E
V
L
H
T
F
D
N
M
T
D
Q
G
L
A
D
V
L
E
R
A
-
H
L
L
Y
---
K
K
W
R
K
E
D
H
L
E
E
R
K
A
Q
L
H
Q
V
A
N
I
L
R
R
D
R
D
K
Y
A
E
I
M
T
K
D
M
G
K
L
F
T
E
A
Q
G
----
E
V
D
L
C
A
D
I
A
D
Y
Y
A
D
K
A
D
E
F
L
M
S
T
-
P
L
E
---
T
D
S
G
Q
A
Y
Y
L
K
Q
S
T
G
V
I
L
A
V
E
P
W
N
F
P
Y
Y
Q
I
M
R
V
F
A
P
N
F
I
V
G
N
P
M
V
L
K
H
A
S
I
C
P
R
S
A
Q
S
F
E
E
L
V
L
E
A
G
A
E
A
G
S
I
T
N
L
F
-
I
S
Y
D
Q
V
S
Q
V
I
A
D
K
R
V
V
G
V
C
L
T
G
S
E
R
G
G
A
S
I
A
E
E
A
G
K
-
N
L
K
K
T
T
L
E
L
G
G
D
D
A
F
I
I
L
D
D
A
D
W
D
Q
L
E
K
V
L
Y
F
S
R
L
Y
N
A
G
Q
V
C
T
S
S
K
R
F
I
V
L
D
K
D
Y
D
R
F
K
E
L
L
T
K
V
F
K
T
A
K
W
G
D
P
M
D
P
E
T
T
L
A
P
L
S
S
A
Q
A
K
A
D
V
L
D
Q
I
K
L
A
L
D
H
G
A
E
L
V
Y
G
G
E
A
I
D
H
P
G
H
F
V
M
P
T
I
I
A
G
L
T
K
D
N
P
I
Y
Y
Q
E
I
F
G
P
V
G
E
I
Y
K
V
S
S
E
E
E
A
I
E
V
A
N
D
S
N
Y
G
L
G
G
T
I
F
S
S
N
Q
E
H
A
K
A
V
A
A
K
I
E
T
G
M
S
F
I
N
S
G
W
T
S
L
P
E
L
P
F
G
G
I
K
H
S
G
Y
G
R
E
L
S
E
L
G
F
T
S
F
V
N
E
H
L
I
Y
I
-
11
PsiBlast_PDB
89.60
37%
-75
- C3 -
4OHT
1
?
A:
[5-454]
----------------------------------------------------------
T
I
Y
P
Y
T
N
E
V
L
H
T
F
D
N
M
T
D
Q
G
L
A
D
V
L
E
R
A
-
H
L
L
Y
---
K
K
W
R
K
E
D
H
L
E
E
R
K
A
Q
L
H
Q
V
A
N
I
L
R
R
D
R
D
K
Y
A
E
I
M
T
K
D
M
G
K
L
F
T
E
A
Q
G
----
E
V
D
L
C
A
D
I
A
D
Y
Y
A
D
K
A
D
E
F
L
M
S
T
-
P
L
E
---
T
D
S
G
Q
A
Y
Y
L
K
Q
S
T
G
V
I
L
A
V
E
P
W
N
F
P
Y
Y
Q
I
M
R
V
F
A
P
N
F
I
V
G
N
P
M
V
L
K
H
A
S
I
C
P
R
S
A
Q
S
F
E
E
L
V
L
E
A
G
A
E
A
G
S
I
T
N
L
F
-
I
S
Y
D
Q
V
S
Q
V
I
A
D
K
R
V
V
G
V
C
L
T
G
S
E
R
G
G
A
S
I
A
E
E
A
G
K
-
N
L
K
K
T
T
L
E
L
G
G
D
D
A
F
I
I
L
D
D
A
D
W
D
Q
L
E
K
V
L
Y
F
S
R
L
Y
N
A
G
Q
V
C
T
S
S
K
R
F
I
V
L
D
K
D
Y
D
R
F
K
E
L
L
T
K
V
F
K
T
A
K
W
G
D
P
M
D
P
E
T
T
L
A
P
L
S
S
A
Q
A
K
A
D
V
L
D
Q
I
K
L
A
L
D
H
G
A
E
L
V
Y
G
G
E
A
I
D
H
P
G
H
F
V
M
P
T
I
I
A
G
L
T
K
D
N
P
I
Y
Y
Q
E
I
F
G
P
V
G
E
I
Y
K
V
S
S
E
E
E
A
I
E
V
A
N
D
S
N
Y
G
L
G
G
T
I
F
S
S
N
Q
E
H
A
K
A
V
A
A
K
I
E
T
G
M
S
F
I
N
S
G
W
T
S
L
P
E
L
P
F
G
G
I
K
H
S
G
Y
G
R
E
L
S
E
L
G
F
T
S
F
V
N
E
H
L
I
Y
I
-
7
PsiBlast_PDB
89.23
44%
-77
- C3 -
3EFV
1
?
A:
[11-458]
----------------------------------------------------------
S
V
N
P
A
T
G
Q
T
L
A
A
M
P
W
A
N
A
Q
E
I
E
H
A
L
S
L
A
-
A
S
G
F
---
K
K
W
K
-
M
T
S
V
A
Q
R
A
Q
T
L
R
D
I
G
Q
A
L
R
A
H
A
E
E
M
A
Q
C
I
T
R
E
M
G
K
P
I
K
Q
A
R
A
----
E
V
T
K
S
A
A
L
C
D
W
Y
A
E
H
G
P
A
M
L
N
P
E
-
P
T
---
L
V
E
N
Q
Q
A
V
I
E
Y
R
P
L
G
V
I
L
A
I
M
P
W
N
F
P
L
W
Q
V
L
R
G
A
V
P
I
L
L
A
G
N
S
Y
L
L
K
H
A
P
N
V
T
G
C
A
Q
M
I
A
R
I
L
A
E
A
G
T
P
A
G
V
Y
G
W
V
N
-
A
N
N
E
G
V
S
Q
M
I
N
D
P
R
I
A
A
V
T
V
T
G
S
V
R
A
G
A
A
I
G
A
Q
A
G
A
-
A
L
K
K
C
V
L
E
L
G
G
S
D
P
F
I
V
L
N
D
A
D
L
E
L
A
V
K
A
A
V
A
G
R
Y
Q
N
T
G
Q
V
C
A
A
A
K
R
F
I
V
E
E
G
I
A
Q
A
F
T
D
R
F
V
A
A
A
A
A
L
K
M
G
D
P
L
V
E
E
N
D
L
G
P
M
A
R
F
D
L
R
D
E
L
H
Q
Q
V
Q
A
S
V
A
E
G
A
R
L
L
L
G
G
E
K
I
A
G
E
G
N
Y
Y
A
A
T
V
L
A
D
V
T
P
D
M
T
A
F
R
Q
E
L
F
G
P
V
A
A
I
T
V
A
K
D
A
A
H
A
L
A
L
A
N
D
S
E
F
G
L
S
A
T
I
F
T
A
D
D
T
L
A
A
E
M
A
A
R
L
E
C
G
G
V
F
I
N
G
Y
S
A
S
D
A
R
V
A
F
G
G
V
K
K
S
G
F
G
R
E
L
S
H
F
G
L
H
E
F
C
N
V
Q
T
V
W
--
13
PsiBlast_PDB
88.99
37%
-75
- C3 -
4YWV
4
?
A:
[5-454]
----------------------------------------------------------
T
I
Y
P
Y
T
N
E
V
L
H
T
F
D
N
M
T
D
Q
G
L
A
D
V
L
E
R
A
-
H
L
L
Y
---
K
K
W
R
K
E
D
H
L
E
E
R
K
A
Q
L
H
Q
V
A
N
I
L
R
R
D
R
D
K
Y
A
E
I
M
T
K
D
M
G
K
L
F
T
E
A
Q
G
----
E
V
D
L
C
A
D
I
A
D
Y
Y
A
D
K
A
D
E
F
L
M
S
T
-
P
L
E
---
T
D
S
G
Q
A
Y
Y
L
K
Q
S
T
G
V
I
L
A
V
E
P
W
N
F
P
Y
Y
Q
I
M
R
V
F
A
P
N
F
I
V
G
N
P
M
V
L
K
H
A
S
I
C
P
R
S
A
Q
S
F
E
E
L
V
L
E
A
G
A
E
A
G
S
I
T
N
L
F
-
I
S
Y
D
Q
V
S
Q
V
I
A
D
K
R
V
V
G
V
C
L
T
G
S
E
R
G
G
A
S
I
A
E
E
A
G
K
-
N
L
K
K
T
T
L
E
L
G
G
D
D
A
F
I
I
L
D
D
A
D
W
D
Q
L
E
K
V
L
Y
F
S
R
L
Y
N
A
G
Q
V
C
T
S
S
K
R
F
I
V
L
D
K
D
Y
D
R
F
K
E
L
L
T
K
V
F
K
T
A
K
W
G
D
P
M
D
P
E
T
T
L
A
P
L
S
S
A
Q
A
K
A
D
V
L
D
Q
I
K
L
A
L
D
H
G
A
E
L
V
Y
G
G
E
A
I
D
H
P
G
H
F
V
M
P
T
I
I
A
G
L
T
K
D
N
P
I
Y
Y
Q
E
I
F
G
P
V
G
E
I
Y
K
V
S
S
E
E
E
A
I
E
V
A
N
D
S
N
Y
G
L
G
G
T
I
F
S
S
N
Q
E
H
A
K
A
V
A
A
K
I
E
T
G
M
S
F
I
N
S
G
W
T
S
L
P
E
L
P
F
G
G
I
K
H
S
G
Y
G
R
E
L
S
E
L
G
F
T
S
F
V
N
E
H
L
I
Y
I
-
12
PsiBlast_PDB
88.39
37%
-76
- C3 -
4YWU
3
?
A:
[5-454]
----------------------------------------------------------
T
I
Y
P
Y
T
N
E
V
L
H
T
F
D
N
M
T
D
Q
G
L
A
D
V
L
E
R
A
-
H
L
L
Y
---
K
K
W
R
K
E
D
H
L
E
E
R
K
A
Q
L
H
Q
V
A
N
I
L
R
R
D
R
D
K
Y
A
E
I
M
T
K
D
M
G
K
L
F
T
E
A
Q
G
----
E
V
D
L
C
A
D
I
A
D
Y
Y
A
D
K
A
D
E
F
L
M
S
T
-
P
L
E
---
T
D
S
G
Q
A
Y
Y
L
K
Q
S
T
G
V
I
L
A
V
E
P
W
N
F
P
Y
Y
Q
I
M
R
V
F
A
P
N
F
I
V
G
N
P
M
V
L
K
H
A
S
I
C
P
R
S
A
Q
S
F
E
E
L
V
L
E
A
G
A
E
A
G
S
I
T
N
L
F
-
I
S
Y
D
Q
V
S
Q
V
I
A
D
K
R
V
V
G
V
C
L
T
G
S
E
R
G
G
A
S
I
A
E
E
A
G
K
-
N
L
K
K
T
T
L
E
L
G
G
D
D
A
F
I
I
L
D
D
A
D
W
D
Q
L
E
K
V
L
Y
F
S
R
L
Y
N
A
G
Q
V
C
T
S
S
K
R
F
I
V
L
D
K
D
Y
D
R
F
K
E
L
L
T
K
V
F
K
T
A
K
W
G
D
P
M
D
P
E
T
T
L
A
P
L
S
S
A
Q
A
K
A
D
V
L
D
Q
I
K
L
A
L
D
H
G
A
E
L
V
Y
G
G
E
A
I
D
H
P
G
H
F
V
M
P
T
I
I
A
G
L
T
K
D
N
P
I
Y
Y
Q
E
I
F
G
P
V
G
E
I
Y
K
V
S
S
E
E
E
A
I
E
V
A
N
D
S
N
Y
G
L
G
G
T
I
F
S
S
N
Q
E
H
A
K
A
V
A
A
K
I
E
T
G
M
S
F
I
N
S
G
W
T
S
L
P
E
L
P
F
G
G
I
K
H
S
G
Y
G
R
E
L
S
E
L
G
F
T
S
F
V
N
E
H
L
I
Y
I
-
48
PsiBlast_CBE
87.64
35%
-75
- C3 -
4FR8
4
ALDH2_HUMAN
D:
[39-491]
----------------------------------------------------------
T
V
N
P
S
T
G
E
V
I
C
Q
V
A
E
G
D
K
E
D
V
D
K
A
V
K
A
A
-
R
A
A
F
QLG
S
P
W
R
-
R
M
D
A
S
H
R
G
R
L
L
N
R
L
A
D
L
I
E
R
D
R
T
Y
L
A
A
L
E
T
L
D
N
G
K
P
Y
V
I
S
Y
L
VDLD
M
V
L
K
C
---
L
R
Y
Y
A
G
W
A
D
K
Y
H
G
K
T
I
P
I
D
----
G
D
F
F
S
Y
T
R
H
E
P
V
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
Q
A
W
K
L
G
P
A
L
A
T
G
N
V
V
V
M
K
V
A
E
Q
T
P
L
T
A
L
Y
V
A
N
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
F
G
P
T
A
G
A
A
I
A
S
H
E
D
V
D
K
V
A
F
T
G
S
T
E
I
G
R
V
I
Q
V
A
A
G
S
S
N
L
K
R
V
T
L
Q
L
G
G
K
S
P
N
I
I
M
S
D
A
D
M
D
W
A
V
E
Q
A
H
F
A
L
F
F
N
Q
G
Q
S
C
S
A
G
S
R
T
F
V
Q
E
D
I
Y
D
E
F
V
E
R
S
V
A
R
A
K
S
R
V
V
G
N
P
F
D
S
K
T
E
Q
G
P
Q
V
D
E
T
Q
F
K
K
I
L
G
Y
I
N
T
G
K
Q
E
G
A
K
L
L
C
G
G
G
I
A
A
D
R
G
Y
F
I
Q
P
T
V
F
G
D
V
Q
D
G
M
T
I
A
K
E
E
I
F
G
P
V
M
Q
I
L
K
F
K
T
I
E
E
V
V
G
R
A
N
N
S
T
Y
G
L
A
A
A
V
F
T
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
G
T
V
W
V
N
C
Y
D
V
F
G
A
Q
S
P
F
G
G
Y
K
M
S
G
S
G
R
E
L
G
E
Y
G
L
Q
A
Y
T
E
V
K
T
V
---
9
PsiBlast_PDB
87.52
41%
-77
- C3 -
3VZ0
1
?
A:
[9-458]
----------------------------------------------------------
T
L
N
P
T
T
E
T
V
E
R
S
F
D
L
H
T
P
A
Q
M
K
D
I
T
D
R
A
E
H
V
W
K
---
T
D
W
K
-
L
R
S
I
A
Q
R
K
E
I
V
S
R
A
A
D
L
L
R
R
D
R
Q
H
H
A
S
L
I
A
T
E
M
G
K
A
L
P
D
A
L
E
----
E
I
D
V
T
A
D
I
L
S
F
Y
A
N
G
A
E
E
F
L
A
P
T
-
P
L
---
K
V
K
T
G
Q
A
K
I
I
N
Q
P
L
G
I
I
Y
C
I
E
P
W
N
F
P
Y
Y
Q
L
A
R
V
A
G
P
N
L
M
A
G
N
V
V
I
A
K
H
A
P
N
V
P
Q
C
A
L
A
F
E
K
L
F
H
D
A
G
A
P
V
G
A
Y
A
N
I
F
-
L
D
N
D
Q
S
A
E
L
I
K
D
E
R
I
R
G
V
A
L
T
G
S
E
R
A
G
Q
A
V
A
A
Q
A
G
A
-
A
L
K
K
D
T
M
E
L
G
G
S
D
A
F
I
V
L
D
D
A
D
L
D
L
A
V
K
W
A
V
W
G
R
F
A
N
N
G
Q
V
C
T
A
A
K
R
M
I
V
H
E
K
V
Y
D
A
F
L
D
G
L
K
T
A
I
T
R
F
R
I
G
N
P
L
D
R
D
T
T
H
G
P
M
S
S
L
R
A
M
E
L
A
L
D
Q
T
A
E
A
V
K
G
G
A
T
L
V
A
G
G
K
R
M
D
R
K
G
F
F
M
E
P
T
I
L
T
D
V
S
K
D
N
P
V
F
Y
Q
E
I
F
G
P
V
A
V
V
H
K
V
A
S
E
Q
A
A
I
D
L
A
N
D
S
P
Y
G
L
G
G
A
V
F
S
R
D
I
A
R
A
E
K
V
A
E
Q
V
E
T
G
M
V
F
I
N
T
A
T
A
A
A
P
E
L
P
F
G
G
I
K
N
S
G
F
G
R
E
L
S
F
L
G
I
E
E
F
I
N
R
K
L
V
R
I
-