@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0248c: (2016-04-20 )
MVEVERHSYDVVVIGAGGAGLRAVIEARERGLKVAVVCKSLFGKAHTVMAEGGCAAAMGNANPKDNWKTHFGDTMRGGKFLNNWRMAELHAKEAPDRVWELETYGALFDRTDDGRISQRNFGGHTYPRLAHVGDRTGLELIRTLQQKVVSLQQEDHAELGDYEARIKVFAECTITELLKDQGAIAGAFGYWRESGRFIVFEAPAVVLATGGIGKSFKVTSNSWEYTGDGHALALRAGATLINMEFVQFHPTGMVWPPSVKGILVTEGVRGDGGVLKNSENSRFMFDYIPPVFKGQYAETEEEADQWLKDNDSARRTPDLLPRDEVARAINSEVKAGRGTPHGGVYLDIASRLTPAEIKRRLPSMYHQFKELAEVDITTQAMEVGPTCHYVMGGVEVDADTGAATVPGLFAAGECAGGMHGSNRLGGNSLSDLLVFGRRAGLGAADYVRALSSRPAVSAEAIDAAAQQALSPFEGPKDGSAPENPYALHMDLQYVMNDLVGIIRNADEISRALTLLAELWSRYHNVLVEGHRQYNPGWNLSIDLRNMLLVSECVARAALQRTESRGGHTRDDHPGMDPNWRRILLVCRATETMGTGGSGSGDSNCHINVTQQLQTPMRPDLLELFEISELEKYYTDEELAEHPGRRG
Atome Classification :
(49 SA)
.........10........20........30-.--........40........50........60--.--.----......70........80........90........100.......110..---------------------...---------------------..-------120..-------..--------.--------..130--.......140.......-150.......160.......170.......180........190.......200.......210......------------.220.......230.....-..240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......-----340-...---......350.......--360--.......370-----..--------------.....380.......390.....--------..400-------.---------..---------.....410...-.-...420.......430.......440.......450.....-..--460.......470.......480.......490.......500.......510.......520...-....-530.....--...----540.......550.......560.......570-...-.-..-----------------.-.580.......590.------------------......600.......610..---......620.......630.......640---------....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
E
V
ERHSY
D
V
V
V
IGAG
G
A
G
L
R
A
V
I
E
A
R
ER--G--L
K
V
A
V
V
C
K
S
L
FGKA
H
T
V
MAEGGCAAAMGNA--N--P----KDNWKTHFGDTMRG
G
K
FLNNW
R
M
A
E
LHAKEAPD
R
V
W
E
L
ETY
G
A
L
FDRTDDG---------------------RIS---------------------QR-------NFGGH-------TY--------P--------RLAHV--GD
R
T
G
L
E
L
I
R
T
L
Q
Q
K
V
V
-
S
L
Q
Q
E
DHAELG
D
Y
E
A
R
I
K
V
F
A
E
C
T
I
T
E
L
L
K
DQ-G
A
I
AGAFGYWRESG
R
F
I
V
F
EA
P
A
V
V
L
A
TGGIG
K
S
F
K
V------------TSN
S
W
E
YTGDG
H
A
L
A
L
RA
G
-
A
T
L
I
N
M
E
F
V
Q
FHPTGMVWPPSVK
G
I
L
V
TEGVRGDG
G
V
L
KNSEN
S
R
F
M
F
DYIPPVFKGQYAE
T
E
E
E
A
D
Q
W
L
KDNDSARRTPDLL
P
R
D
E
V
A
R
A
I
N
S
E
VKAGRGT-----P---HG
G
---
V
Y
L
D
I
A
SRL
T
P
A
E
I
K
R
--
R
L
P
--
S
M
Y
H
Q
F
K
E
L
A
-----
E
V--------------DITT
Q
A
MEVGPT
C
H
Y
V
MG
G
V
E
V
D--------ADTG--------A---------AT---------V
P
G
L
F
A
A
G
E
CA-G-GMHGSNRLGG
N
S
L
S
D
L
L
V
F
GRRAGL
G
A
A
D
Y
V
R
A
L
SSRPAV
S
-
A
E
--
A
I
D
A
A
A
Q
QALSPFEGPKDGSAPEN
P
Y
A
L
H
M
D
L
Q
Y
V
M
N
D
L
V
G
I
IR
N
A
D
E
I
S
R
A
L
T
L
L
A
E
L
W
S
R
Y
H
N
V
-
L
V
EG-H-RQYNPG--W
N
L
----
S
I
D
L
R
N
M
L
L
V
S
E
C
V
A
R
A
A
L
Q
R
T
ESRGGHTRDD--HPG-M-DP-----------------N-
W
R
R
I
L
L
V
C
RATETMG------------------TGGSGSGDS
N
C
H
I
N
V
T
Q
Q
-LQ---TPM
R
P
D
L
L
E
L
F
E
I
S
E
L
E
K
YY
T
D
E
E
L
A
EHP---------GRRG-
103
HHSearch
94.52
36%
-73
* C3 *
2H88
4
SDHA_CHICK
A:
[14-589]
---
V
V
D
H
E
F
D
A
V
V
V
G
A
G
G
A
G
L
R
A
A
F
G
L
S
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
D
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
A
V
I
E
L
E
N
Y
G
M
P
F
S
R
T
E
E
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
QFGKGGQA
H
--------
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
S
L
-
R
Y
D
-------------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
T
I
H
R
F
R
A
K
N
T
V
I
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
A
----
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
I
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
Q
Q
L
A
T
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
G
Q
V
I
T
H
V
NG
E
D
---------
K
V
---------
V
P
G
L
Y
A
C
G
E
A
A
-
S
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
T
I
A
E
T
C
K
P
G
E
P
V
P
S
I
K
-
P
N
--
A
G
E
E
S
V
A
N
L
D
K
L
R
----
F
A
D
G
T
I
R
T
S
E
A
R
L
N
M
Q
K
T
M
Q
S
H
A
A
V
F
R
T
G
S
I
L
Q
E
G
C
E
K
L
S
Q
I
Y
R
D
L
A
H
L
-
K
T
F
D
R
G
-
I
V
W
N
T
D
--
L
V
E
----
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
Y
K
L
-
R
-
I
D
EFDYSKPLQG
Q
Q
K
R
P
FE
E
H
W
R
K
H
T
L
S
Y
V
D
V
-----------------------------------------------------------------------------------------
104
HHSearch
92.48
38%
-74
- C3 -
2WDQ
4
SDHA_ECOLI
A:
[3-563]
---
L
P
V
R
E
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
-----
H
----
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
-------
P
F
G
G
Q
SKNFGG
E
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
N
L
-
K
N
H
-------------
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
A
G
A
----
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
N
A
-------------------------
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
-----
D
G
PW
G
P
H
---
A
K
L
K
L
-
D
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
L
T
V
N
EKG
E
D
V
V
---------
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
H
L
Q
E
S
I
A
E
Q
G
A
L
R
D
A
S
-
E
S
--
D
V
E
A
S
L
D
R
L
N
R
W
N
----
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
-
R
L
D
D
T
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
-
D
D
-----------------
E
N
W
L
C
H
S
L
Y
L
P
E
S
-----------------------------------------------------------------------------------------
124
Fugue
91.23
31%
-61
- C3 -
1E7P
1
FRDA_WOLSU
A:
[1-655]
---
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
--
K
MS
D
----
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
D
R
M
A
IINAQKT
T
I
T
E
E
DFRHG
L
I
H
---------------------
S
R
-------
D
F
G
G
T
-------
K
K
--------
W
--------
R
T
C
Y
T
--
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
G
-------------
V
S
I
Q
D
R
K
E
A
I
A
L
I
H
Q
D
-
G
K
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
------------
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
----
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
P
-------------------------
E
K
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
-----
Q
---
S
P
Y
G
Q
H
L
W
L
D
I
-
S
I
L
G
R
K
H
I
E
T
--
N
L
R
--
D
V
Q
E
I
C
E
Y
F
A
-----
G
I
--------------
D
P
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
D
--------
Y
R
-
G
--------
E
---------
A
K
---------
L
K
G
L
F
S
A
G
E
A
A
-
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
--
T
Q
V
D
L
E
-
T
K
--
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
-
G
I
K
N
-
K
R
L
H
A
N
P
E
--
L
E
E
----
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
P
K
R
D
-
D
I
-----------------
N
-
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
VNEMEIAP
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
-
K
R
---
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
AKYKARN
E
R
L
G
D
105
HHSearch
91.06
34%
-73
- C3 -
1KF6
5
FRDA_ECOLI
A:
[2-560]
----
Q
T
F
Q
A
D
L
A
I
V
G
A
G
G
A
G
L
R
A
A
I
A
A
A
Q
A
NP
N
--
A
K
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
S
A
A
V
A
Q
-------
D
----
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
N
---------------------
V
R
-------
R
F
G
G
M
-------
K
I
--------
E
--------
R
T
W
F
A
--
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
Q
-------------
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
D
D
-
G
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
------------
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
----
G
I
L
M
T
E
G
C
R
G
E
G
G
I
L
V
N
K
N
G
Y
R
Y
L
Q
D
Y
G
M
G
P
E
T
---
P
L
---------
G
E
P
K
--
N
K
Y
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
I
S
T
P--
R
---
G
D
V
---
V
Y
L
D
L
-
R
H
L
G
E
K
K
L
H
E
--
R
L
P
--
F
I
C
E
L
A
K
A
Y
V
-----
G
V
--------------
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
D
--------
Q
N
C
E
------------------
T
R
---------
I
K
G
L
F
A
V
G
E
C
S
-
S
V
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
G
N
G
N
E
A
A
I
E
A
--
Q
A
A
G
V
E
Q
R
L
K
D
L
V
----
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
-
R
I
T
D
T
S
-
S
V
F
N
T
D
--
L
L
Y
----
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
D
EG
C
T
E
-
R
-
D
D
-----------------
V
N
F
L
K
H
T
L
A
F
R
D
A
D
G
---------------------------------------------------------------------------------------
102
HHSearch
90.93
32%
-70
- C3 -
2BS2
3
FRDA_WOLSU
A:
[2-599]
----
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
KM
S
--
D
----
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---------------------
D
R
M
AIINAQK
T
T
I
T
E
E
DFRHG
L
I
H
S
R
-------
D
F
G
G
T
-------
K
K
--------
W
--------
R
T
C
Y
T
--
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
G
-------------
V
S
I
Q
D
R
K
E
A
I
A
L
I
H
Q
D
-
G
K
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
------------
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
----
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
P
E
-------------------------
K
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P--
Y
---
G
Q
H
---
L
W
L
D
I
-
S
I
L
G
R
K
H
I
E
T
--
N
L
R
--
D
V
Q
E
I
C
E
Y
F
A
-----
G
I
--------------
D
P
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
D
--------
Y
R
G
E
------------------
A
K
---------
L
K
G
L
F
S
A
G
E
A
A
-
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
-
T
L
E
K
F
V
K
G
Q
E
A
Y
M
-
K
S
L
V
---
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
-
G
I
K
N
K
R
-
L
H
A
N
P
E
--
L
E
E
----
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
P
K
-
R
-
D
D
-----------------
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
------------------
L
-----------
P
T
L
E
Y
E
A
L
D
VNE
M
E
I
A
P
G
Y
R
G
Y
G
A
-------------------------------
123
Fugue
90.77
33%
-69
- C3 -
1L0V
2
FRDA_ECOLI
A:
[1-577]
---
M
Q
T
F
Q
A
D
L
A
I
V
G
A
G
G
A
G
L
R
A
A
I
A
A
A
Q
A
--
N
PN
A
K
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
S
A
A
V
A
-----
Q
--
D
----
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
N
---------------------
V
R
-------
R
F
G
G
M
-------
K
I
--------
E
--------
R
T
W
F
A
--
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
-
Q
---
F
P
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
D
D
----------
G
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
------------
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
----
S
G
I
L
M
T
E
G
C
R
G
E
G
G
I
L
V
N
K
N
G
Y
R
Y
L
Q
D
Y
--------------
G
M
G
P
E
T
P
L
G
E
P
K
N
K
Y
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
I
-----
S
---
T
P
R
G
D
V
V
Y
L
D
L
-
R
H
L
G
E
K
K
L
H
E
--
R
L
P
--
F
I
C
E
L
A
K
A
Y
V
-----
G
V
--------------
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
D
--------
Q
N
-
C
--------
E
---------
T
R
---------
I
K
G
L
F
A
V
G
E
C
S
-
S
V
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
G
N
G
N
E
A
A
-
I
E
--
A
Q
A
A
G
V
E
Q
R
L
K
D
L
V
N
Q
D
G
G
---
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
-
R
I
T
D
-
T
S
S
V
F
N
T
D
--
L
L
Y
----
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
D
--
E
G
C
-
T
-
E
R
-----------------
D
-
D
V
N
F
L
K
H
T
L
A
F
R
--------------------------
D
A
D
G
T
T
R
L
E
Y
S
D
V
-
K
I
---
T
T
L
P
P
A
-------------------------------------
25
PsiBlast_CBE
89.14
35%
-69
- C3 -
2WS3
10
SDHA_ECOLI
I:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
PFGGQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
DGPWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
VNEKGEDVV
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
9
PsiBlast_PDB
89.14
35%
-67
- C3 -
2WU2
3
SDHA_ECOLI
A:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
P
F
G
GQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
PW
G
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
7
PsiBlast_PDB
89.12
35%
-67
- C3 -
2WP9
3
SDHA_ECOLI
A:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
P
F
G
GQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
PW
G
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
8
PsiBlast_PDB
89.02
35%
-70
- C3 -
2WS3
3
SDHA_ECOLI
A:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
P
F
G
GQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
PW
G
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
29
PsiBlast_CBE
89.00
35%
-68
- C3 -
2WDV
7
SDHA_ECOLI
I:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
PFGGQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
DGPWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
VNEKGEDVV
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
27
PsiBlast_CBE
88.98
35%
-68
- C3 -
2WP9
10
SDHA_ECOLI
I:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
PFGGQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
DGPWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
VNEKGEDVV
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
28
PsiBlast_CBE
88.95
35%
-68
- C3 -
2WP9
3
SDHA_ECOLI
E:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
PFGGQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
DGPWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
VNEKGEDVV
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.92
35%
-69
- C3 -
2WDV
3
SDHA_ECOLI
A:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
P
F
G
GQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
PW
G
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.89
35%
-67
- C3 -
2WDQ
4
SDHA_ECOLI
A:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
P
F
G
GQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
PW
G
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
26
PsiBlast_CBE
88.84
35%
-69
- C3 -
2WS3
3
SDHA_ECOLI
E:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
PFGGQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
DGPWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
VNEKGEDVV
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
10
PsiBlast_PDB
88.80
35%
-66
- C3 -
2WU5
3
SDHA_ECOLI
A:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
P
F
G
GQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
PW
G
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
24
PsiBlast_CBE
88.77
35%
-67
- C3 -
2WU2
3
SDHA_ECOLI
E:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
PFGGQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
DGPWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
VNEKGEDVV
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
30
PsiBlast_CBE
88.76
35%
-68
- C3 -
2WDV
3
SDHA_ECOLI
E:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
PFGGQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
DGPWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
VNEKGEDVV
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.72
35%
-66
- C3 -
2WU5
10
SDHA_ECOLI
I:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
PFGGQSK
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
DGPWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
VNEKGEDVV
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.77
35%
-64
- C3 -
1NEN
3
SDHA_ECOLI
A:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
PFGG
Q
S
K
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
PWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.21
35%
-61
- C3 -
1NEK
3
SDHA_ECOLI
A:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
P
FGG
Q
S
K
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
PWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.72
35%
-61
- C3 -
2ACZ
2
SDHA_ECOLI
A:
[8-566]
--------
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
--
H
-------
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
Y
---------------------
Q
R
P
FGG
Q
S
K
N
F
G
G
E
-------
Q
A
--------
A
--------
R
T
A
A
A
--
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
--------------
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
------------
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
P
-------------------------
N
A
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
PWG
P
---
H
A
K
---
L
K
L
D
---
H
L
G
K
E
V
L
E
S
--
R
L
P
--
G
I
L
E
L
S
R
T
F
A
-----
H
V
--------------
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
--------
A
---------
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
----
H
L
Q
E
S
I
A
E
Q
G
A
L
-
R
D
--
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
-
S
-
S
E
F
N
T
Q
--
R
V
E
----
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
P
D
-
R
D
D
E
-----------------
N
-
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
--------------------------------------------------------------------------------------
90
PsiBlast_CBE
83.79
31%
-63
- C3 -
3AE3
1
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
83.77
31%
-67
- C3 -
3AEB
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
83.62
31%
-64
- C3 -
3AEC
1
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
83.61
31%
-64
- C3 -
3ABV
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
83.29
31%
-64
- C3 -
1ZOY
1
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
83.23
31%
-64
- C3 -
3AE9
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
83.18
31%
-64
- C3 -
3AED
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YK
G
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
83.17
31%
-63
- C3 -
4YXD
1
?
A:
[82-596]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
83.17
31%
-63
- C3 -
3AE1
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
83.17
31%
-63
- C3 -
3AE8
1
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKG
G
Q
A
H
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
83.11
31%
-62
- C3 -
3AE7
1
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
83.08
31%
-63
- C3 -
3AEE
1
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKGQ
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
82.99
31%
-64
- C3 -
3AEA
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
82.95
31%
-64
- C3 -
3SFD
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
82.88
31%
-64
- C3 -
1ZP0
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
82.87
31%
-64
- C3 -
3SFE
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
82.86
31%
-66
- C3 -
3AE2
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
82.86
31%
-65
- C3 -
3AEF
1
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
82.81
31%
-64
- C3 -
3AE4
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YK
G
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
82.79
31%
-63
- C3 -
3AE5
2
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKG
G
Q
A
H
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
82.76
31%
-64
- C3 -
3AEG
1
SDHA_PIG
A:
[40-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKG
G
Q
A
H
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
82.45
31%
-63
- C3 -
4YTP
1
SDHA_PIG
A:
[82-596]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
M
P
F
S
R
T
E
D
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
K
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
S
I
H
R
I
R
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
L
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
E
Q
L
A
V
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
--------
D
---------
Q
V
---------
V
P
G
L
Y
A
C
G
E
A
A
C
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
K
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
V
G
S
V
L
Q
E
G
C
E
K
I
L
R
L
Y
G
D
L
Q
H
L
--------
K
T
F
D
R
G
MV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
---------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
81.98
31%
-63
- C3 -
2H89
14
SDHA_CHICK
A:
[39-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
D
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
A
V
I
E
L
E
N
Y
G
M
P
F
S
R
T
E
E
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
Q
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
T
I
H
R
F
R
A
K
N
T
V
I
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
I
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
Q
Q
L
A
T
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
G
Q
--------
V
---------
I
T
H
V
NG
E
D
K
V
-
V
P
G
L
Y
A
C
G
E
A
A
S
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
T
I
A
E
T
C
K
P
G
E
P
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
A
N
L
D
K
L
R
F
A
D
G
T
I
R
T
S
E
A
R
L
N
M
Q
K
T
M
Q
S
H
A
A
V
F
R
T
G
S
I
L
Q
E
G
C
E
K
L
S
Q
I
Y
R
D
L
A
H
L
--------
K
T
F
D
R
G
IV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
Y
------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
81.91
31%
-64
- C3 -
1YQ3
5
SDHA_CHICK
A:
[39-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
D
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
A
V
I
E
L
E
N
Y
G
M
P
F
S
R
T
E
E
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
Q
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
T
I
H
R
F
R
A
K
N
T
V
I
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
I
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
Q
Q
L
A
T
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
G
Q
--------
V
---------
I
T
H
V
NG
E
D
K
V
-
V
P
G
L
Y
A
C
G
E
A
A
S
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
T
I
A
E
T
C
K
P
G
E
P
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
A
N
L
D
K
L
R
F
A
D
G
T
I
R
T
S
E
A
R
L
N
M
Q
K
T
M
Q
S
H
A
A
V
F
R
T
G
S
I
L
Q
E
G
C
E
K
L
S
Q
I
Y
R
D
L
A
H
L
--------
K
T
F
D
R
G
IV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
Y
------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
81.64
31%
-61
- C3 -
1YQ4
2
SDHA_CHICK
A:
[39-554]
----------------------------
E
A
--
G
--
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
--
E
-------
D
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
A
V
I
E
L
E
N
Y
G
M
P
F
S
R
T
E
E
G
---------------------
K
I
Y
---------------------
Q
R
-------
A
F
G
G
Q
-------
S
L
--------
Q
FGKGGQAH
R
C
C
C
V
--
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
---
S
L
R
Y
D
-----------
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
-
G
E
C
R
G
V
I
A
L
C
I
E
D
G
T
I
H
R
F
R
A
K
N
T
V
I
A
T
G
G
Y
G
R
T
Y
F
S
------------
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
----
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-------------------------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
I
E
I
R
E
G
R
G
C
GP---
E
---
K
D
H
---
V
Y
L
Q
L
-
H
H
L
P
P
Q
Q
L
A
T
--
R
L
P
--
G
I
S
E
T
A
M
I
F
A
-----
G
V
--------------
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
G
Q
--------
V
---------
I
T
H
V
NG
E
D
K
V
-
V
P
G
L
Y
A
C
G
E
A
A
S
A
-
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
T
I
A
E
T
C
K
P
G
E
P
V
P
S
I
K
-
P
N
------
A
G
E
E
S
V
A
N
L
D
K
L
R
F
A
D
G
T
I
R
T
S
E
A
R
L
N
M
Q
K
T
M
Q
S
H
A
A
V
F
R
T
G
S
I
L
Q
E
G
C
E
K
L
S
Q
I
Y
R
D
L
A
H
L
--------
K
T
F
D
R
G
IV
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
Y
------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
67.93
32%
-52
- C3 -
1Y0P
5
FRDA_SHEFR
A:
[122-568]
---
A
P
H
D
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
--
G
--
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
T
D
Q
--
Q
--
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
--------------------------------------------------------
M
G
G
A
-------
S
V
--------
N
--------
R
A
H
R
P
T
G
G
A
G
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
-
K
R
N
-------------
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
D
K
G
T
V
K
G
I
L
V
K
G
M
-
Y
K
G
Y
Y
W
V
K
A
D
A
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
DPSLKGFI
S
T
N
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
----
G
V
M
V
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
--------
K
S
L
S
-
K
I
D
K
Y
I
G
L
G
------------------
V
A
P
T
A
-
D
S
L
--
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
DTDFERPNLPRALN
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
--------
T
K
A
E
V
M
N
AK---
K
---------
Q
V
---------
I
P
G
L
Y
G
A
G
E
V
T
-
G
-
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------