@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0322: (2016-04-21 )
MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEYGADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQLADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH
Atome Classification :
(26 SA)
.........10........20....--....30........40........50........60........70........80........90-...----.....100.......110---...----....120......----.130.......---.--140-....--.....150.......160.......170....--..--.180.......190.....-.---..200.......210.......220.......230.......240.......250.--....---..260.......270.......280.......290....-----...300...---....310..---.....320.......330.......340.......350.......360----......-------..--.-----------370---........380.......390.......400.......-410-...-....420.....---..430.......440.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
C
S
V
F
GTGYLG
A
T
H
A
V
G
M
A
Q
LGH
E
--
V
V
G
V
DIDPG
K
V
AKLAGGDIPFY
E
P
G
L
R
K
L
L
T
DNLAAG
R
L
R
F
TTDYDMAADFA
D
V
H
F
L
GVG
T
P
Q
K
I
G
-
E
YG----A
D
L
R
H
V
H
A
V
I
D
A
L
V
P
R
L
V
---
R
A
S
----
I
L
VGKSTVPVG
T
A
----
A
E
L-GHRAGAL---A--P---R
G
V
D
--
V
E
I
A
W
N
P
E
F
L
REGFAVHDTL
N
P
D
R
I
V
L
G
VQDD--S
T
--
R
A
E
V
A
V
R
E
L
Y
A
P
L
-
L
AAGV-
P
---
F
L
V
TDLQ
T
A
E
L
V
K
VSAN
A
F
L
A
T
K
I
S
F
I
N
A
I
S
E
V
C
E
AAGA
D
V
S
Q
L
A
D
ALGYD
P
R
I
G
R
--
Q
C
L
N
---AGLGFGGGC
L
P
K
D
I
R
A
F
M
A
RAGEL
G
A
D
Q
A
L
T
F
L
R
E
V
D
S
I
-----
N
M
R
R
R
T
K
M
V
---
E
L
A
TTACGG---SLLGA
N
I
A
V
L
GAAFKPESDDVRDSPALN
V
A
G
Q
L
Q
LN
G
A
T
V
H
V
YD
P
K
------ALD
N
A
H
-------
R
L
--
F
-----------
P
T
----
L
N
Y
A
V
S
V
A
E
A
C
E
RA
D
A
V
L
V
L
T
E
W
R
E
FIDL
E
P
A
D
L
A
N
R
V
-
R
A
R
-
V
I
V-DGRNCL
D
V
T
R
W
R
---
R
AG
W
R
V
F
RLGVPRLGH
30
PsiBlast_CBE
96.87
36%
-101
- C3 -
2Y0D
6
?
C:
[9-460]
M
N
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-----
S
----
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
27
PsiBlast_CBE
96.63
36%
-103
- C3 -
2Y0C
11
?
C:
[9-460]
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
-
D
G
S
----
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
G
--Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
3
PsiBlast_PDB
96.60
36%
-101
- C3 -
2Y0E
10
?
A:
[9-460]
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
-
D
G
S
----
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
23
PsiBlast_CBE
96.54
36%
-106
- C3 -
2Y0E
7
?
D:
[9-460]
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
------------
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
5
PsiBlast_PDB
96.48
36%
-100
- C3 -
2Y0D
7
?
A:
[9-460]
M
N
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
---
S
----
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
29
PsiBlast_CBE
96.40
36%
-102
- C3 -
2Y0D
4
?
D:
[9-460]
M
N
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
-----
G
S
----
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
G
G
D
QM
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
VP
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
ALDLADH----
P
S
WLER
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
4
PsiBlast_PDB
96.38
36%
-99
- C3 -
2Y0C
11
?
A:
[9-460]
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
-
D
G
S
----
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
108
HHSearch
96.30
36%
-97
- C3 -
2Y0C
11
?
A:
[9-463]
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
E
D
--
G
S
----
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
-
R
A
A
V
A
E
E
---
L
--
A
K
R
G
G
D
Q
M
--
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
--
V
P
G
E
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH
P
S
W
L
E
R
----
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
-
26
PsiBlast_CBE
96.23
36%
-104
- C3 -
2Y0C
9
?
D:
[9-460]
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
------------
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
25
PsiBlast_CBE
96.11
36%
-100
- C3 -
2Y0E
9
?
B:
[9-460]
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
-----------
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
---Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
28
PsiBlast_CBE
96.03
36%
-104
- C3 -
2Y0C
11
?
B:
[9-460]
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-------------
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
---Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
31
PsiBlast_CBE
95.50
36%
-103
- C3 -
2Y0D
3
?
B:
[9-460]
M
N
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-------
S
----
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
G
G
-Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
24
PsiBlast_CBE
95.35
36%
-102
- C3 -
2Y0E
13
?
C:
[9-460]
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
H
D
--
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
-
D
G
S
----
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
----
V
I
V
D
K
S
T
V
P
V
G
T
A
----
E
R
V
R
A
A
V
A
E
E
L
---
A
--
K
---
R
---M-
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
--
R
A
R
E
L
M
K
K
L
Y
A
P
F
-
N
R
N
H
E
-
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
--
Q
S
L
Q
I
L
K
A
V
S
S
V
-----
N
A
T
Q
K
R
V
L
A
---
D
K
I
V
A
R
F
G
E
---
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
------
A
Q
E
E
A
R
-------
R
V
--
I
A
L
D
L
A
DH----
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
L
W
-
K
T
P
-
V
I
F
-
D
G
R
N
L
Y
E
P
E
T
M
S
---
E
Q
G
I
E
Y
H
P
I
G
R
P
----
115
HHSearch
94.46
36%
-101
* C3 *
3GG2
4
?
A:
[3-436]
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
A
N
--
V
R
C
I
D
T
D
R
N
K
I
E
Q
L
N
S
G
T
I
P
I
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
A
G
E
D
--
G
S
----
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
Y
I
----
L
I
V
T
K
S
T
V
P
V
G
S
Y
----
R
L
I
-
R
K
A
I
Q
E
E
L
D
K
R
--
E
---
V
L
I
D
--
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
S
D
--
R
----
A
R
E
L
I
T
S
L
Y
K
P
M
-
L
L
-
N
N
F
R
---
V
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
--
K
F
L
Y
---
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
D
N
G
Y
R
--
M
E
V
L
E
A
V
E
R
V
-----
N
E
K
Q
K
S
I
L
F
---
D
K
F
S
T
Y
Y
K
G
---
N
V
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
V
------
A
M
K
E
A
Q
-------
K
R
L-
G
-----------
D
K
----
V
E
Y
T
T
D
M
Y
D
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
A
L
S
Q
A
M
-
A
A
S
-
L
V
I
-
D
G
R
N
V
Y
E
L
P
---------
F
T
L
L
N
I
G
------
81
PsiBlast_CBE
93.50
32%
-100
- C3 -
3KHU
8
UGDH_HUMAN
B:
[7-447]
-
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
P
E
IR
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
-
E
S
C
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
Y
-
G
M
G
KGRA
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
----
I
V
T
E
K
S
T
V
P
V
R
A
A
----
E
S
I
-
R
R
I
F
D
A
N
---
T
--
K
---
P
N
L
N
--
L
Q
V
L
S
N
P
Q
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
-
G
D
E
--
T
P
--
E
G
Q
R
A
V
Q
A
L
C
A
-
V
-
Y
E
H
W
V
-
P
REK
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
--
K
F
L
K
---
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
E
V
A
R
Y
W
Q
Q
V
I
D
M
-----
N
D
Y
Q
R
R
R
F
A
---
S
R
I
I
D
S
L
F
N
---
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
K
VPREQI
V
V
D
L
S
H
PGVSEDD
Q
V
--
S
-----------
R
L
----
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
A
-
F
I
F
-
D
G
R
R
V
L
D
------------------------
78
PsiBlast_CBE
93.43
32%
-100
- C3 -
3KHU
3
UGDH_HUMAN
E:
[7-447]
-
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
P
E
IR
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
-
E
S
C
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
Y
-
G
M
G
KGRA
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
----
I
V
T
E
K
S
T
V
P
V
R
A
A
----
E
S
I
-
R
R
I
F
D
A
N
---
T
--
K
---
P
N
L
N
--
L
Q
V
L
S
N
P
Q
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
-
G
D
E
--
T
P
--
E
G
Q
R
A
V
Q
A
L
C
A
-
V
-
Y
E
H
W
V
-
P
REK
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
--
K
F
L
K
---
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
E
V
A
R
Y
W
Q
Q
V
I
D
M
-----
N
D
Y
Q
R
R
R
F
A
---
S
R
I
I
D
S
L
F
N
---
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
K
VPREQI
V
V
D
L
S
H
PGVSEDD
Q
V
--
S
-----------
R
L
----
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
A
-
F
I
F
-
D
G
R
R
V
L
D
------------------------
60
PsiBlast_CBE
93.07
32%
-99
- C3 -
2QG4
10
UGDH_HUMAN
G:
[7-447]
-
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
P
E
IR
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
-
E
S
C
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
Y
-
G
M
G
KGRA
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
----
I
V
T
E
K
S
T
V
P
V
R
A
A
----
E
S
I
-
R
R
I
F
D
A
N
---
T
--
K
---
P
N
L
N
--
L
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
-
G
D
E
--
T
P
--
E
G
Q
R
A
V
Q
A
L
C
A
-
V
-
Y
E
H
W
V
-
P
REK
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
--
K
F
L
K
---
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
E
V
A
R
Y
W
Q
Q
V
I
D
M
-----
N
D
Y
Q
R
R
R
F
A
---
S
R
I
I
D
S
L
F
N
---
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
K
VPREQI
V
V
D
L
S
H
D------
Q
V
--
S
-----------
R
L
----
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
A
-
F
I
F
-
D
G
R
R
V
L
D
------------------------
88
PsiBlast_CBE
92.98
32%
-99
- C3 -
3ITK
4
UGDH_HUMAN
C:
[7-447]
-
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
P
E
IR
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
-
E
S
C
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
Y
-
G
M
G
KGRA
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
----
I
V
T
E
K
S
A
V
P
V
R
A
A
----
E
S
I
-
R
R
I
F
D
A
N
---
T
--
K
---
P
N
L
N
--
L
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
-
G
D
E
--
T
P
--
E
G
Q
R
A
V
Q
A
L
C
A
-
V
-
Y
E
H
W
V
-
P
REK
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
--
K
F
L
K
---
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
E
V
A
R
Y
W
Q
Q
V
I
D
M
-----
N
D
Y
Q
R
R
R
F
A
---
S
R
I
I
D
S
L
F
N
---
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
K
VPREQI
V
V
D
L
S
H
PGVSEDD
Q
V
--
S
-----------
R
L
----
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
A
-
F
I
F
-
D
G
R
R
V
L
D
------------------------
77
PsiBlast_CBE
92.94
32%
-101
- C3 -
3KHU
3
UGDH_HUMAN
F:
[7-447]
-
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
P
E
IR
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
-
E
S
C
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
Y
-
G
M
G
KGRA
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
----
I
V
T
E
K
S
T
V
P
V
R
A
A
----
E
S
I
-
R
R
I
F
D
A
N
---
T
--
K
---
P
N
L
N
--
L
Q
V
L
S
N
P
Q
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
-
G
D
E
--
T
P
--
E
G
Q
R
A
V
Q
A
L
C
A
-
V
-
Y
E
H
W
V
-
P
REK
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
--
K
F
L
K
---
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
E
V
A
R
Y
W
Q
Q
V
I
D
M
-----
N
D
Y
Q
R
R
R
F
A
---
S
R
I
I
D
S
L
F
N
---
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
K
VPREQI
V
V
D
L
S
H
PD-----
Q
V
--
S
-----------
R
L
----
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
A
-
F
I
F
-
D
G
R
R
V
L
D
------------------------
15
PsiBlast_PDB
92.87
32%
-100
- C3 -
3KHU
7
UGDH_HUMAN
A:
[7-447]
-
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
P
E
I
R
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
-
E
S
C
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
Y
-
G
M
G
KGRA
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
----
I
V
T
E
K
S
T
V
P
V
R
A
A
----
E
S
I
-
R
R
I
F
D
A
N
---
T
--
K
---
P
N
L
N
--
L
Q
V
L
S
N
P
Q
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
-
G
D
E
--
T
P
--
E
G
Q
R
A
V
Q
A
L
C
A
-
V
-
Y
E
H
W
V
-
P
REK
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
--
K
F
L
K
---
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
E
V
A
R
Y
W
Q
Q
V
I
D
M
-----
N
D
Y
Q
R
R
R
F
A
---
S
R
I
I
D
S
L
F
N
---
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
K
VP
R
E
Q
I
V
V
D
L
S
H
PD
D
----
Q
V
--
S
-----------
R
L
----
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
A
-
F
I
F
-
D
G
R
R
V
L
D
------------------------
112
HHSearch
91.75
39%
-96
- C3 -
3VTF
2
?
A:
[22-443]
A
S
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
G
H
R
--
V
V
G
Y
D
V
N
P
S
I
V
E
R
L
R
A
G
R
P
H
I
Y
E
P
G
L
E
E
A
L
G
R
A
L
S
S
G
R
L
S
F
A
E
S
A
E
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
P
D
--
G
S
----
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
R
A
K
G
R
W
H
----
L
V
V
V
K
S
T
V
P
P
G
T
T
----
E
G
L
-
V
A
R
A
V
A
E
---
E
--
A
---
G
G
V
K
--
F
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
A
G
D
E
--
R
----
A
A
S
F
L
L
D
V
Y
K
A
V
-
D
---
A
-
P
---
K
L
V
M
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
I
G
R
--
H
Y
F
G
---
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
E
S
L
G
L
E
--
M
A
I
S
K
A
V
L
R
V
-----
N
E
Y
M
P
R
Y
A
V
---
Q
L
L
E
E
R
L
G
----
G
L
R
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
P
M
------
A
M
E
K
A
R
-------
A
V
--
L
G----------
D
S
----
V
T
Y
V
E
D
P
Q
A
L
L
D
Q
V
E
G
V
I
I
A
T
A
W
P
Q
Y
E
G
L
D
Y
--------
R
G
K
-
V
V
V
-
D
G
R
Y
V
K
K
A
R
-------
E
A
K
I
Y
E
G
V
A
W
-----
107
HHSearch
91.40
40%
-98
- C3 -
4A7P
1
?
A:
[9-443]
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
G
H
E
--
V
V
C
V
D
K
D
A
R
K
I
E
L
L
H
Q
N
V
M
P
I
Y
E
P
G
L
D
A
L
V
A
S
N
V
K
A
G
R
L
S
F
T
T
D
L
A
E
G
V
K
D
A
D
A
V
F
I
A
V
G
T
P
S
R
R
G
-
D
G
H
----
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L
T
---
K
P
S
----
V
I
V
T
K
S
T
V
P
V
G
T
G
----
D
E
V
-
E
R
I
I
A
E
V
---
A
------
P
N
S
G
--
A
K
V
V
S
N
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
T
E
D
E
--
F
----
A
R
Q
V
M
R
E
I
Y
R
P
L
-
S
-----
P
---
V
L
F
T
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
I
-----
F
L
H
---
A
G
P
G
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
T
A
A
D
N
E
T
P
--
L
R
I
V
E
A
T
V
Q
V
-----
N
D
A
R
K
R
A
M
G
---
R
K
V
I
K
A
M
G
G
---
D
V
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
E
------
G
V
E
Q
A
S
-------
K
M
--
L
-----------
T
D
----
V
E
F
V
E
N
P
Y
A
A
A
D
G
A
D
A
L
V
I
V
T
E
W
D
A
F
R
A
L
D
L
T
R
I
K
N
S
L
-
K
S
P
-
V
L
V
-
D
L
R
N
I
Y
P
P
A
E
L
E
---
R
A
G
L
Q
Y
T
G
V
G
K
P
----
1
PsiBlast_PDB
91.20
39%
-97
- C3 -
4A7P
1
?
A:
[9-443]
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
G
H
E
--
V
V
C
V
D
K
D
A
R
K
I
E
L
L
H
Q
N
V
M
P
I
Y
E
P
G
L
D
A
L
V
A
S
N
V
K
A
G
R
L
S
F
T
T
D
L
A
E
G
V
K
D
A
D
A
V
F
I
A
V
G
T
P
S
R
R
G
-
D
G
H
----
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L
T
---
K
P
S
----
V
I
V
T
K
S
T
V
P
V
G
T
G
----
D
E
V
-
E
R
I
I
A
E
V
---
A
--
P
---
N
S
-
G
--
A
K
V
V
S
N
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
T
E
D
E
--
F
A
--
R
Q
--
V
M
R
E
I
Y
R
P
L
S------
P
---
V
L
F
T
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
I
-----
F
L
H
---
A
G
P
G
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
T
A
A
D
--
N
E
T
P
L
R
I
V
E
A
T
V
Q
V
-----
N
D
A
R
K
R
A
M
G
---
R
K
V
I
K
A
M
G
G
---
D
V
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
E
------
G
V
E
Q
A
S
-------
K
M
--
L
-----------
T
D
----
V
E
F
V
E
N
P
Y
A
A
A
D
G
A
D
A
L
V
I
V
T
E
W
D
A
F
R
A
L
D
L
T
R
I
K
N
S
L
-
K
S
P
-
V
L
V
-
D
L
R
N
I
Y
P
P
A
E
L
E
---
R
A
G
L
Q
Y
T
G
V
G
K
P
----
6
PsiBlast_PDB
91.05
40%
-95
- C3 -
3VTF
2
?
A:
[24-427]
--
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
G
H
R
--
V
V
G
Y
D
V
N
P
S
I
V
E
R
L
R
A
G
R
P
H
I
Y
E
P
G
L
E
E
A
L
G
R
A
L
S
S
G
R
L
S
F
A
E
S
A
E
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
P
--
D
G
S
----
A
D
L
R
Y
V
E
A
A
A
R
A
-
V
G
R
G
I
---
R
A
K
G
R
W
H
L
V
V
V
K
S
T
V
P
P
G
T
T
----
E
G
L
-
V
A
R
A
V
A
E
---
E
--
A
---
G
G
V
K
--
F
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
A
G
D
E
------
R
A
A
S
F
L
L
D
V
Y
K
----
A
V
D
A
-
P
---
K
L
V
M
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
I
G
R
--
H
Y
F
G
---
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
E
S
L
G
L
E
M
A
I
S
--
K
A
V
L
R
V
-----
N
E
Y
M
P
R
Y
A
V
---
Q
L
L
E
E
R
L
G
G
----
L
R
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
P
M
------
A
M
E
K
A
R
-------
A
V
--
L
G----------
D
S
----
V
T
Y
V
E
D
P
Q
A
L
L
D
Q
V
E
G
V
I
I
A
T
A
W
P
Q
Y
E
G
L
D
-------
Y
-
R
G
K
-
V
V
V
-
D
G
R
----------------------------
94
PsiBlast_CBE
80.24
33%
-87
- C3 -
4XR9
3
?
A:
[16-442]
L
K
V
V
I
A
G
A
G
Y
V
G
T
C
L
A
V
T
L
A
G
R
G
A
E
--
V
V
A
V
D
S
D
P
G
T
V
A
D
L
R
A
G
R
C
R
L
P
E
P
G
L
A
G
A
V
R
D
L
A
A
T
G
R
L
T
A
S
T
S
Y
D
P
V
G
-
A
A
D
V
V
I
V
T
V
G
T
P
T
D
A
G
H
E
M
V
----
T
D
--
Q
L
V
A
A
C
E
Q
I
A
P
R
L
R
---
A
G
Q
----
L
V
I
L
K
S
T
V
S
P
G
T
T
RTL
V
A
P
L
-
L
E
S
G
G
L
V
---
H
--
E
---
R
--
D
--
F
G
L
A
F
C
P
E
R
L
A
E
G
V
A
L
A
Q
V
R
T
L
P
V
V
V
G
G
C
-----
G
P
--
R
S
A
A
A
A
E
R
F
W
R
S
A
-
L
G
V
D
V
-----
R
Q
V
P
S
A
E
S
A
E
V
V
K
L
A
T
N
W
W
I
D
A
N
V
A
I
A
N
E
L
A
R
Y
C
A
V
L
G
V
D
V
L
D
V
I
G
A
A
N
T
L
P
K
-
G
S
--
S
M
V
N
LLL
P
G
V
G
V
G
G
S
C
L
T
K
D
--
P
W
M
A
W
--
R
D
G
R
D
R
G
V
S
-
L
R
T
V
E
T
A
R
A
V
N
D
D
M
P
R
H
T
A
A
V
I
A
D
E
L
--
V
K
L
G
R
---
D
R
N
D
T
T
I
A
V
L
G
A
A
F
K
N
D
T
G
D
V
R
N
T
P
V
R
G
V
V
A
A
L
R
D
S
G
F
R
V
R
I
F
D
P
L
------
A
-
D
P
A
E
-------
I
V
A
R
F
-----------
G
T
----
A
P
-
A
A
S
L
D
E
A
V
S
G
A
G
C
L
A
F
L
A
G
H
R
Q
F
H
E
L
D
F
G
A
L
A
E
R
V
-
D
E
P
-
C
L
V
F
D
G
R
M
H
L
P
P
A
R
I
R
-------------------
114
HHSearch
80.16
30%
-86
- C3 -
4XR9
3
?
A:
[16-456]
L
K
V
V
I
A
G
A
G
Y
V
G
T
C
L
A
V
T
L
A
G
R
G
A
E
--
V
V
A
V
D
S
D
P
G
T
V
A
D
L
R
A
G
R
C
R
L
P
E
P
G
L
A
G
A
V
R
D
L
A
A
T
G
R
L
T
A
S
T
S
Y
-
D
P
V
G
A
A
D
V
V
I
V
T
V
G
T
P
T
D
A
G
--
H
E
----
M
V
T
D
Q
L
V
A
A
C
E
Q
I
A
P
R
L
R
---
A
G
Q
----
L
V
I
L
K
S
T
V
S
P
G
T
T
----
R
T
L
-
V
A
P
L
L
E
S
---
G
GL
V
---
H
E
R
D
--
F
G
L
A
F
C
P
E
R
L
A
E
G
V
A
L
A
Q
V
R
T
L
P
V
V
V
G
G
C
G
P
R
--
S
-----
A
A
A
A
E
R
F
W
R
S
A
-
L
G
-
V
D
-
V
---
R
Q
V
P
S
A
E
S
A
E
V
V
K
L
A
T
N
W
W
I
D
A
N
V
A
I
A
N
E
L
A
R
Y
C
A
V
L
G
V
D
V
L
D
V
I
G
A
A
N
T
L
P
K
G
S
S
MV
N
L
L
L
---
P
G
V
G
V
G
G
S
C
L
T
K
D
P
W
M
A
W
R
D
G
R
D
R
G
V
S
--
L
R
T
V
E
T
A
R
A
V
-----
N
D
D
M
P
R
H
T
A
---
A
V
I
A
D
E
L
V
K
L
GR
D
R
N
D
T
T
I
A
V
L
G
A
A
F
K
N
D
T
G
D
V
R
N
T
P
V
R
G
V
V
A
A
L
R
D
S
G
F
R
V
R
I
F
D
P
L
------
A
D
P
A
E
I
-------
V
A
--
R
-----------
F
G
----
T
A
P
A
A
S
L
D
E
A
V
S
G
A
G
C
L
A
F
L
A
G
H
R
Q
F
H
E
L
D
F
G
A
L
A
E
R
V
-
D
E
P
C
L
V
F
-
D
G
R
M
H
L
P
P
A
R
I
R
E
L
H
R
F
G
F
A
Y
R
G
I
G
R
-----