@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0327c: (2016-04-21 )
MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFSLRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHARMRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFGVTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIASRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLWELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPAGTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTEGAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP
Atome Classification :
(20 SA)
.........10..-......20..-......30........40........50..---......60........70........80.-........90........100.......110.......120.......130....-------...----140.......150.......160--------.....-..170.......180.......190.......200.......210......---.220.......230.......240-..--.....250.......260.......270.......280....--...290..--.-----------..-.-----------.300.......310.......320.....--..330.......340.......350.......360..---....-------------------.370.......380.......390.......400.......410....-...420.......430.......440.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASTLTTGLPPGP-
R
L
P
R
Y
L
Q
S
V
L
-
Y
L
R
F
R
E
W
F
L
P
A
M
H
R
KYG
D
V
F
S
L
RVPPYAD
N
---
L
V
V
Y
TR
P
E
H
I
K
E
I
F
AADPRSLHAGEG
N
-
H
-
I
L
G
F
V
MGE
H
S
V
L
MTD
E
A
E
H
A
R
M
R
S
L
L
M
P
A
F
T
R
A
A
L
R
G
Y
R
D
M
I
A
S
V
A
R
E
H
I
T
RWRP-------HAT----INSLDHM
N
A
L
T
L
D
I
I
L
R
V
V
FGVT--------D
P
K
V
K
-
A
E
L
T
S
R
L
Q
Q
I
I
NI
H
P
A
I
LAGVPYPSLKRM
N
P
W
K
R
F
FHNQ
T
K
I
D
E
I
L
Y
R
E
I
A
---
S
R
RIDS
D
L
T
A
R
T
D
V
L
S
R
L
L
QTKDT-PT--KPLT
D
A
E
L
R
D
Q
L
I
T
L
L
LAGHE
T
T
A
A
A
L
S
W
T
L
W
E
L
AHAPEIQS--
Q
V
V
W
A
A
VG--G-----------D
D
-
G
-----------
F
L
E
A
V
L
K
E
G
M
R
R
H
T
V
I
A
STARKVTAPAEI--G
G
W
RLPAG
T
V
V
N
T
S
I
L
L
A
H
A
S
EVSHPKPTEFRPSRFL---DGSV-------------------APNTWLPFG
G
G
V
R
R
C
L
GF
G
F
A
LT
E
G
A
V
I
L
Q
E
I
F
R
R
F
T
I
TAAGPSKGET-
P
L
V
RNITTVPKHG
A
H
L
R
L
I
P
Q
R
RLGGLGDSDPP
2
PsiBlast_PDB
95.17
25%
-96
- C3 -
1TQN
1
CP3A4_HUMAN
A:
[18-444]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
Q
K
H
R
V
D
F
L
Q
L
M
I
D
S
Q
N
S
---S
H
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
--------------------------------------------
13
PsiBlast_PDB
94.16
24%
-96
- C3 -
5A1P
3
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
MK
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
S
---SH
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
5
PsiBlast_PDB
94.10
24%
-95
- C3 -
4I3Q
1
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
Q
K
H
R
V
D
F
L
Q
L
M
I
D
S
Q
N
S
---H-
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
20
PsiBlast_PDB
93.83
25%
-99
- C3 -
2V0M
3
CP3A4_HUMAN
A:
[17-443]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
-----
V
D
F
L
Q
L
M
I
D
S
Q
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
--------------------------------------------
3
PsiBlast_PDB
93.74
24%
-98
- C3 -
3UA1
2
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
---
E
D
T
Q
---
V
D
F
L
Q
L
M
I
D
S
Q
-----H-
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
14
PsiBlast_PDB
93.73
24%
-101
- C3 -
5A1R
2
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
-----
R
V
D
F
L
Q
L
M
I
D
S
Q
N
S
---H-
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
11
PsiBlast_PDB
93.73
24%
-96
- C3 -
4K9W
2
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
------
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
21
HHSearch
93.48
23%
-99
- C3 -
2VE3
2
CP120_SYNY3
A:
[11-442]
------
L
P
I
P
P
G
D
F
G
L
P
W
L
G
E
T
L
N
-
F
L
N
D
-
G
D
F
G
K
K
R
Q
Q
Q
F
G
P
I
F
K
T
R
L
F
G
--
K
N
---
V
I
F
I
S
G
A
L
A
N
R
F
L
F
T
K
E
Q
E
T
F
Q
A
T
W
P
--
L
-
S
T
R
I
L
L
G
P
N
A
L
A
T
Q
M
G
E
I
H
R
S
R
R
K
I
L
Y
Q
A
F
L
P
R
T
L
D
S
Y
L
P
K
M
D
G
I
V
Q
G
Y
L
E
Q
W
G
K
-------
A
N
E
----
V
I
W
Y
P
Q
L
R
R
M
T
F
D
V
A
A
T
L
F
M
G
E
K
--------
V
S
Q
N
--
P
Q
L
F
P
W
F
E
T
Y
I
Q
G
L
F
S
--
L
P
I
P
L
P
N
T
----
L
F
G
K
S
Q
R
A
R
A
L
L
L
A
E
L
E
K
I
I
K
---
A
R
Q
Q
Q
P
--
P
S
E
E
D
A
L
G
I
L
L
A
A
R
D
D
-
N
N
--
Q
P
L
S
L
P
E
L
K
D
Q
I
L
L
L
L
F
A
G
H
E
T
L
T
S
A
L
S
S
F
C
L
L
L
G
Q
H
S
D
I
R
E
--
R
V
R
Q
E
Q
N
K
L
Q
L
SQELT
A
E
T
L
--
K
K
M
P
-----------
Y
L
D
Q
V
L
Q
E
V
L
R
L
I
P
P
V
G
G
G
F
R
E
L
I
Q
D
C
Q
F
--
Q
G
F
H
F
P
K
G
W
L
V
S
Y
Q
I
S
Q
T
H
A
D
P
D
L
Y
P
D
P
E
K
F
D
P
E
R
F
T
---
P
D
G
S
ATHN---------------
P
P
F
A
H
V
P
F
G
G
G
L
R
E
C
L
G
K
E
F
A
R
L
E
M
K
L
F
A
T
R
L
I
Q
Q
F
D
W
T
L
L
P
-
G
Q
N
L
--
E
L
V
V
T
P
S
P
R
P
K
D
N
L
R
V
K
L
H
S
-------------
15
PsiBlast_PDB
93.26
24%
-94
- C3 -
4D78
4
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
--
H
R
V
D
F
L
Q
L
M
I
D
S
Q
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
16
PsiBlast_PDB
92.03
24%
-93
- C3 -
4D7D
2
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
--
H
R
V
D
F
L
Q
L
M
I
D
S
Q
N
-------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
10
PsiBlast_PDB
92.00
24%
-98
- C3 -
4K9V
2
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
----
V
D
F
L
Q
L
M
I
D
S
Q
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
6
PsiBlast_PDB
91.99
24%
-91
- C3 -
4I4G
2
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
-------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
1
PsiBlast_PDB
91.91
25%
-101
- C3 -
4NY4
2
CP3A4_HUMAN
A:
[16-442]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
Q
-----
F
L
Q
L
M
I
D
S
Q
-----SH
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
--------------------------------------------
8
PsiBlast_PDB
91.88
24%
-96
- C3 -
4K9T
3
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
TGKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
-----
D
F
L
Q
L
M
I
D
S
Q
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
7
PsiBlast_PDB
91.52
24%
-92
- C3 -
4I4H
2
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
-------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
4
PsiBlast_PDB
91.13
24%
-97
- C3 -
3TJS
2
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
-------
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
----
H
R
V
D
F
L
Q
L
M
I
D
S
Q
N
-------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
38
HHSearch
90.85
23%
-89
- C3 -
4LXJ
3
CP51_YEAST
A:
[57-532]
---------
P
L
V
F
Y
W
I
P
W
V
G
S
A
V
V
-
Y
G
M
K
P
Y
E
F
F
E
E
C
Q
K
K
Y
G
D
I
F
S
F
V
L
L
G
--
R
V
---
M
T
V
Y
L
G
P
K
G
H
E
F
V
F
N
A
K
L
A
D
V
S
A
E
A
A
Y
A
H
-
L
T
T
P
V
F
G
K
G
V
I
Y
D
C
P
N
S
R
L
M
E
Q
K
K
F
V
K
G
A
L
T
K
E
A
F
K
S
Y
V
P
L
I
A
E
E
V
Y
K
Y
F
R
D
S
K
N
FRLNERT
T
G
T
----
I
D
V
M
V
T
Q
P
E
M
T
I
F
T
A
S
R
S
L
L
G
K
E
--------
M
R
A
K
L
D
T
D
F
A
Y
L
Y
S
D
L
D
K
G
F
T
P
I
--
N
F
V
F
P
N
L
-
P
L
E
H
Y
R
K
R
D
H
A
Q
K
A
I
S
G
T
Y
M
S
L
I
K
---
E
R
R
K
N
N
D
-
I
Q
D
R
D
L
I
D
S
L
M
K
N
S
T
Y
K
D
G
--
V
K
M
T
D
Q
E
I
A
N
L
L
I
G
V
L
M
G
G
Q
H
T
S
A
A
T
S
A
W
I
L
L
H
L
A
E
R
P
D
V
Q
Q
--
E
L
Y
E
E
Q
M
R
V
L
D
GGKKELT
Y
D
L
L
Q
E
M
P
-----------
L
L
N
Q
T
I
K
E
T
L
R
M
H
H
P
L
H
S
L
F
R
K
V
M
K
D
M
H
V
P
N
T
S
Y
V
I
P
A
G
Y
H
V
L
V
S
P
G
Y
T
H
L
R
D
E
Y
F
P
N
A
H
Q
F
N
I
H
R
W
N
---
N
D
S
A
SSYSV
G
E
E
V
D
YGFGAISKG
V
S
S
P
Y
L
P
F
G
G
G
R
H
R
C
I
G
E
H
F
A
Y
C
Q
L
G
V
L
M
S
I
F
I
R
T
L
K
W
H
Y
P
E
-
G
K
T
V
P
P
P
D
F
T
S
M
V
T
L
P
T
G
P
A
K
I
I
W
E
K
R
N
P
E
Q
K
I
G
G
----
18
PsiBlast_PDB
90.58
25%
-97
- C3 -
1W0F
2
CP3A4_HUMAN
A:
[17-443]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
-------
V
D
F
L
Q
L
M
I
D
S
Q
N
-------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPTYDTVLQM
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
--------------------------------------------
12
PsiBlast_PDB
90.26
24%
-96
- C3 -
4K9X
2
CP3A4_HUMAN
A:
[19-452]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNP---------
N
T
K
K
L
L
--
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
-------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
PPT
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
-------------------------------------
19
PsiBlast_PDB
89.94
25%
-99
- C3 -
1W0G
2
CP3A4_HUMAN
A:
[17-443]
----------
P
G
P
-
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
-----
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
-
F
G
P
V
G
F
M
--
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
-------
E
A
E
T
GKP
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
IDSLNNPQ
D
P
F
V
---
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
-------
F
L
Q
L
M
I
-----------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
--
P
-----------
N
K
-
A
P
P
T
YDTVLQM
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
--
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
KKN
K
D
N
I
-------------------
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
--------------------------------------------