@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0400c: (2016-04-22 )
MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAAWFEDGDLPVARDLAKQFGELGLLGMQLHGHGCGGASAVHYGLACRELEAADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARRDGPDWVITGGKMWITNGSVADVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAMLPGATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFGKLNNTREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGLAAFR
Atome Classification :
(35 SA)
.........10......---..20........30........40.......--.50...-.....60........70----..-.-.....-80........90........100.......110.......120.......130.......140.......150-.-.....-.160..-..--.....170.......180.......190-------.-----.-.......200.......210.......220.......230.....--..240........250.......260.......270.......280.......290.......300.......310.......320.....--..330.......340.......350.......360.......370.......380.......390...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTPTPPALDRDDPLGL---DASLSSDE
I
A
V
R
D
T
V
R
R
F
C
A
E
HVT
P
H
V
A
A
W
F--EDGDL
P
-
V
A
R
D
L
A
K
Q
F
G
ELG
L
L
G
M
----
Q
L
-H-GHGCG-
G
A
S
A
V
H
YG
L
A
C
R
E
L
E
A
A
D
S
G
I
R
S
L
V
S
VQG
S
L
A
M
F
A
I
ASFGS
D
E
Q
K
R
QWLPGMATGD
L
L
G
CFGLTEPDVGS
D
P
A
-
A
-
M
K
T
R
A-RR--DG-P
D
--
W
V
I
TG
G
K
M
W
I
TNGSV
A
D
V
A
I
V
W
A
ATD---------D-----G-
I
R
G
F
I
V
PTDTPGFTANTIG
H
K
L
S
L
R
A
S
I
T
S
E
L
V
LDNVRLP
A
D
AML--PGA-TGL
R
A
P
L
A
C
L
S
EAR
Y
G
I
V
WGAM
G
A
A
R
S
A
W
Q
C
A
L
D
Y
A
R
Q
R
T
QFGRPIAGFQ
L
T
Q
A
K
L
V
D
M
A
V
E
LHK
G
Q
L
L
S
L
H
L
G
R
L
K
D
RVGLRPDQV--SFGKLN
N
T
R
E
A
L
K
I
C
R
T
A
R
T
I
LGGNG
I
S
L
E
Y
P
V
I
R
H
M
V
N
L
E
S
VLTYEG
T
P
E
M
H
Q
L
V
L
G
Q
A
F
T
GLAAFR
1
PsiBlast_PDB
98.91
69%
-99
- C2 -
3SF6
17
?
A:
[21-403]
-----------
D
D
L
I
G
I
---
N
A
V
L
S
A
E
E
R
E
I
R
D
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
--
E
D
G
E
L
P
--
A
R
E
L
A
V
E
L
G
E
L
G
L
L
G
M
----
H
L
-
K
-
G
Y
G
C
A
-
G
M
S
A
V
A
Y
G
L
A
C
L
E
L
E
A
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
E
P
D
H
G
S
D
P
A
-
G
-
M
R
T
R
A
-
T
R
--
S
G
-
D
D
--
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
A
D
V
A
V
V
W
A
R
T
D
---------
E
-----
G
-
I
R
G
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
P
D
S
A
R
L
--
P
G
A
-
T
S
L
G
A
P
L
R
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
D
M
T
L
E
Y
G
K
G
F
L
L
A
L
H
L
G
R
Q
K
D
A
G
E
L
A
P
E
Q
V
--
S
L
G
K
L
N
N
V
R
E
A
I
E
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
G
E
Y
P
V
M
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
T
G
V
G
A
F
R
109
HHSearch
97.30
69%
-101
- C2 -
3SF6
17
?
A:
[26-403]
----------------
I
---
N
A
V
L
S
A
E
E
R
E
I
R
D
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
--
E
D
G
E
L
P
A
R
--
E
L
A
V
E
L
G
E
L
G
L
L
G
M
----
H
L
-
K
-
G
Y
G
C
A
-
G
M
S
A
V
A
Y
G
L
A
C
L
E
L
E
A
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
E
P
D
H
G
S
D
P
A
-
G
-
M
R
T
R
A
-
T
R
--
S
G
-
D
D
--
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
A
D
V
A
V
V
W
A
R
T
D
---------
E
-----
G
-
I
R
G
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
P
D
S
A
R
L
--
P
G
A
-
T
S
L
G
A
P
L
R
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
D
M
T
L
E
Y
G
K
G
F
L
L
A
L
H
L
G
R
Q
K
D
A
G
E
L
A
P
E
Q
V
--
S
L
G
K
L
N
N
V
R
E
A
I
E
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
G
E
Y
P
V
M
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
T
G
V
G
A
F
R
22
PsiBlast_CBE
94.97
62%
-100
- C2 -
3SWO
12
?
C:
[13-398]
----------
T
Y
A
P
L
E
L
FDT
D
R
L
L
D
Q
D
E
R
D
I
A
A
T
V
R
Q
F
V
D
T
R
L
K
P
N
V
E
G
W
F
--
E
S
A
T
L
P
---
S
E
L
A
K
E
F
G
N
L
G
V
L
G
M
----
H
L
-
Q
-
G
Y
G
C
A
-
G
T
N
A
V
S
Y
G
L
A
C
M
E
L
E
A
G
D
S
G
F
R
S
F
V
S
V
Q
G
S
L
S
M
F
S
I
Y
R
Y
G
S
E
E
Q
K
N
E
W
L
P
R
L
A
A
G
D
A
I
G
C
F
G
L
T
E
P
D
F
G
S
N
P
A
-
G
-
M
R
T
R
A
-
R
R
--
D
G
-
S
D
--
W
I
L
N
G
T
K
M
W
I
T
N
G
N
L
A
D
V
A
T
V
W
A
Q
T
D
---------
D
-----
G
-
I
R
G
F
L
V
P
T
D
T
P
G
F
T
A
N
E
I
H
R
K
L
S
L
R
A
S
V
T
S
E
L
V
L
D
N
V
R
L
P
A
S
A
Q
L
--
P
L
A
-
E
G
L
S
A
P
L
S
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
S
L
E
T
T
I
A
Y
T
Q
S
R
E
V
F
D
K
P
L
S
N
Y
Q
L
T
Q
E
K
L
A
N
M
T
V
E
L
G
K
G
M
L
L
A
I
H
L
G
R
I
K
D
A
E
G
V
R
P
E
Q
I
--
S
L
G
K
L
N
N
V
R
E
A
I
A
I
A
R
E
C
R
T
L
L
G
G
S
G
I
T
L
E
Y
S
P
L
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
L
L
S
I
G
K
A
L
T
G
K
A
A
F
R
23
PsiBlast_CBE
94.43
62%
-100
- C2 -
3SWO
5
?
B:
[13-398]
----------
T
Y
A
P
L
E
L
F
DT
D
R
L
L
D
Q
D
E
R
D
I
A
A
T
V
R
Q
F
V
D
T
R
L
K
P
N
V
E
G
W
F
--
E
S
A
T
L
P
---
S
E
L
A
K
E
F
G
N
L
G
V
L
G
M
----
H
L
-
Q
-
G
Y
G
C
A
-
G
T
N
A
V
S
Y
G
L
A
C
M
E
L
E
A
G
D
S
G
F
R
S
F
V
S
V
Q
G
S
L
S
M
F
S
I
Y
R
Y
G
S
E
E
Q
K
N
E
W
L
P
R
L
A
A
G
D
A
I
G
C
F
G
L
T
E
P
D
F
G
S
N
P
A
-
G
-
M
R
T
R
A
-
R
R
--
D
G
-
S
D
--
W
I
L
N
G
T
K
M
W
I
T
N
G
N
L
A
D
V
A
T
V
W
A
Q
T
D
---------
D
-----
G
-
I
R
G
F
L
V
P
T
D
T
P
G
F
T
A
N
E
I
H
R
K
L
S
L
R
A
S
V
T
S
E
L
V
L
D
N
V
R
L
P
A
S
A
Q
L
--
P
L
A
-
E
G
L
S
A
P
L
S
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
S
L
E
T
T
I
A
Y
T
Q
S
R
E
V
F
D
K
P
L
S
N
Y
Q
L
T
Q
E
K
L
A
N
M
T
V
E
L
G
K
G
M
L
L
A
I
H
L
G
R
I
K
D
A
E
G
V
R
P
E
Q
I
--
S
L
G
K
L
N
N
V
R
E
A
I
A
I
A
R
E
C
R
T
L
L
G
G
S
G
I
T
L
E
Y
S
P
L
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
L
L
S
I
G
K
A
L
T
G
K
A
A
F
R
21
PsiBlast_CBE
94.34
62%
-98
- C2 -
3SWO
9
?
D:
[13-398]
----------
T
Y
A
P
L
E
L
FDT
D
R
L
L
D
Q
D
E
R
D
I
A
A
T
V
R
Q
F
V
D
T
R
L
K
P
N
V
E
G
W
F
--
E
S
A
T
L
P
---
S
E
L
A
K
E
F
G
N
L
G
V
L
G
M
----
H
L
-
Q
-
G
Y
G
C
A
-
G
T
N
A
V
S
Y
G
L
A
C
M
E
L
E
A
G
D
S
G
F
R
S
F
V
S
V
Q
G
S
L
S
M
F
S
I
Y
R
Y
G
S
E
E
Q
K
N
E
W
L
P
R
L
A
A
G
D
A
I
G
C
F
G
L
T
E
P
D
F
G
S
N
P
A
-
G
-
M
R
T
R
A
-
R
R
--
D
G
-
S
D
--
W
I
L
N
G
T
K
M
W
I
T
N
G
N
L
A
D
V
A
T
V
W
A
Q
T
D
---------
D
-----
G
-
I
R
G
F
L
V
P
T
D
T
P
G
F
T
A
N
E
I
H
R
K
L
S
L
R
A
S
V
T
S
E
L
V
L
D
N
V
R
L
P
A
S
A
Q
L
--
P
L
A
-
E
G
L
S
A
P
L
S
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
S
L
E
T
T
I
A
Y
T
Q
S
R
E
V
F
D
K
P
L
S
N
Y
Q
L
T
Q
E
K
L
A
N
M
T
V
E
L
G
K
G
M
L
L
A
I
H
L
G
R
I
K
D
A
E
G
V
R
P
E
Q
I
--
S
L
G
K
L
N
N
V
R
E
A
I
A
I
A
R
E
C
R
T
L
L
G
G
S
G
I
T
L
E
Y
S
P
L
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
L
L
S
I
G
K
A
L
T
G
K
A
A
F
R
2
PsiBlast_PDB
94.28
62%
-98
- C2 -
3SWO
5
?
A:
[11-398]
--------
K
S
T
Y
A
P
L
E
L
F
D
T
D
R
L
L
D
Q
D
E
R
D
I
A
A
T
V
R
Q
F
V
D
T
R
L
K
P
N
V
E
G
W
F
--
E
S
A
T
L
P
---
S
E
L
A
K
E
F
G
N
L
G
V
L
G
M
----
H
L
-
Q
-
G
Y
G
C
A
-
G
T
N
A
V
S
Y
G
L
A
C
M
E
L
E
A
G
D
S
G
F
R
S
F
V
S
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G
S
L
S
M
F
S
I
Y
R
Y
G
S
E
E
Q
K
N
E
W
L
P
R
L
A
A
G
D
A
I
G
C
F
G
L
T
E
P
D
F
G
S
N
P
A
-
G
-
M
R
T
R
A
-
R
R
--
D
G
-
S
D
--
W
I
L
N
G
T
K
M
W
I
T
N
G
N
L
A
D
V
A
T
V
W
A
Q
T
D
---------
D
-----
G
-
I
R
G
F
L
V
P
T
D
T
P
G
F
T
A
N
E
I
H
R
K
L
S
L
R
A
S
V
T
S
E
L
V
L
D
N
V
R
L
P
A
S
A
Q
L
--
P
L
A
-
E
G
L
S
A
P
L
S
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
S
L
E
T
T
I
A
Y
T
Q
S
R
E
V
F
D
K
P
L
S
N
Y
Q
L
T
Q
E
K
L
A
N
M
T
V
E
L
G
K
G
M
L
L
A
I
H
L
G
R
I
K
D
A
E
G
V
R
P
E
Q
I
--
S
L
G
K
L
N
N
V
R
E
A
I
A
I
A
R
E
C
R
T
L
L
G
G
S
G
I
T
L
E
Y
S
P
L
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
L
L
S
I
G
K
A
L
T
G
K
A
A
F
R
106
HHSearch
93.39
63%
-98
- C2 -
3SWO
5
?
A:
[16-398]
----------
P
L
E
L
F
D
T
---
D
R
L
L
D
Q
D
E
R
D
I
A
A
T
V
R
Q
F
V
D
T
R
L
K
P
N
V
E
G
W
F
--
E
S
A
T
L
P
-
S
--
E
L
A
K
E
F
G
N
L
G
V
L
G
M
----
H
L
-
Q
-
G
Y
G
C
A
-
G
T
N
A
V
S
Y
G
L
A
C
M
E
L
E
A
G
D
S
G
F
R
S
F
V
S
V
Q
G
S
L
S
M
F
S
I
Y
R
Y
G
S
E
E
Q
K
N
E
W
L
P
R
L
A
A
G
D
A
I
G
C
F
G
L
T
E
P
D
F
G
S
N
P
A
-
G
-
M
R
T
R
A
-
R
R
--
D
G
-
S
D
--
W
I
L
N
G
T
K
M
W
I
T
N
G
N
L
A
D
V
A
T
V
W
A
Q
T
D
---------
D
-----
G
-
I
R
G
F
L
V
P
T
D
T
P
G
F
T
A
N
E
I
H
R
K
L
S
L
R
A
S
V
T
S
E
L
V
L
D
N
V
R
L
P
A
S
A
Q
L
--
P
L
A
-
E
G
L
S
A
P
L
S
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
S
L
E
T
T
I
A
Y
T
Q
S
R
E
V
F
D
K
P
L
S
N
Y
Q
L
T
Q
E
K
L
A
N
M
T
V
E
L
G
K
G
M
L
L
A
I
H
L
G
R
I
K
D
A
E
G
V
R
P
E
Q
I
--
S
L
G
K
L
N
N
V
R
E
A
I
A
I
A
R
E
C
R
T
L
L
G
G
S
G
I
T
L
E
Y
S
P
L
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
L
L
S
I
G
K
A
L
T
G
K
A
A
F
R
26
PsiBlast_CBE
88.27
52%
-98
- C2 -
2EBA
3
?
G:
[3-385]
------------
D
F
Y
A
L
---
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
--
E
E
G
V
F
P
-
T
--
H
L
I
P
R
F
A
E
L
G
F
L
G
P
----
T
L
-
P
P
E
Y
G
G
A
-
G
V
S
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
-
G
N
M
K
T
R
A
-
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
-----------------E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
--
P
K
A
-
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
--
S
L
A
K
R
Q
N
V
W
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A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
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T
L
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H
A
I
R
H
M
L
N
L
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T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
27
PsiBlast_CBE
87.52
52%
-96
- C2 -
2EBA
3
?
F:
[3-385]
------------
D
F
Y
A
L
---
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
--
E
E
G
V
F
P
-
T
--
H
L
I
P
R
F
A
E
L
G
F
L
G
P
----
T
L
-
P
P
E
Y
G
G
A
-
G
V
S
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
-
G
N
M
K
T
R
A
-
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
-----------------E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
--
P
K
A
-
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
--
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
28
PsiBlast_CBE
87.46
52%
-96
- C2 -
2EBA
3
?
E:
[3-385]
------------
D
F
Y
A
L
---
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
--
E
E
G
V
F
P
-
T
--
H
L
I
P
R
F
A
E
L
G
F
L
G
P
----
T
L
-
P
P
E
Y
G
G
A
-
G
V
S
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
-
G
N
M
K
T
R
A
-
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
-----------------E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
--
P
K
A
-
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
--
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
24
PsiBlast_CBE
87.45
52%
-96
- C2 -
2EBA
3
?
I:
[3-385]
------------
D
F
Y
A
L
---
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
--
E
E
G
V
F
P
-
T
--
H
L
I
P
R
F
A
E
L
G
F
L
G
P
----
T
L
-
P
P
E
Y
G
G
A
-
G
V
S
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
-
G
N
M
K
T
R
A
-
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
-----------------E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
--
P
K
A
-
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
--
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
110
HHSearch
87.32
53%
-98
- C2 -
2EBA
3
?
A:
[7-385]
----------------
L
---
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
--
E
E
G
V
F
P
-
T
--
H
L
I
P
R
F
A
E
L
G
F
L
G
P
----
T
L
P
P
-
E
Y
G
G
A
-
G
V
S
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
G
N
-
M
K
T
R
A
-
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
----------------
E
-
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
--
P
K
A
-
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
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P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
--
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
3
PsiBlast_PDB
87.18
52%
-97
- C2 -
2EBA
3
?
A:
[3-385]
------------
D
F
Y
A
L
---
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
--
E
E
G
V
F
P
-
T
--
H
L
I
P
R
F
A
E
L
G
F
L
G
P
----
T
L
-
P
P
E
Y
G
G
A
-
G
V
S
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
-
G
N
M
K
T
R
A
-
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
-----------------E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
--
P
K
A
-
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
--
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
25
PsiBlast_CBE
86.91
52%
-94
- C2 -
2EBA
3
?
H:
[3-385]
------------
D
F
Y
A
L
---
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
--
E
E
G
V
F
P
-
T
--
H
L
I
P
R
F
A
E
L
G
F
L
G
P
----
T
L
-
P
P
E
Y
G
G
A
-
G
V
S
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
-
G
N
M
K
T
R
A
-
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
-----------------E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
--
P
K
A
-
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
--
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
29
PsiBlast_CBE
86.59
52%
-95
- C2 -
2EBA
3
?
D:
[3-385]
------------
D
F
Y
A
L
---
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
--
E
E
G
V
F
P
-
T
--
H
L
I
P
R
F
A
E
L
G
F
L
G
P
----
T
L
-
P
P
E
Y
G
G
A
-
G
V
S
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
-
G
N
M
K
T
R
A
-
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
-----------------E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
--
P
K
A
-
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
--
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
30
PsiBlast_CBE
86.23
52%
-96
- C2 -
2EBA
3
?
C:
[3-385]
------------
D
F
Y
A
L
---
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
--
E
E
G
V
F
P
-
T
--
H
L
I
P
R
F
A
E
L
G
F
L
G
P
----
T
L
-
P
P
E
Y
G
G
A
-
G
V
S
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
-
G
N
M
K
T
R
A
-
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
-----------------E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
--
P
K
A
-
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
--
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
108
HHSearch
83.83
49%
-92
- C2 -
3II9
3
?
A:
[4-395]
-----
A
A
T
F
H
W
D
D
P
L
L
L
---
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
--
R
H
E
T
T
D
-
A
--
A
I
F
R
E
M
G
E
I
G
L
L
G
P
----
T
I
P
E
-
Q
Y
G
G
P
-
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
-------
S
-
M
V
T
R
A
-
R
K
--
V
P
-
G
G
--
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
D
EDG
R
-----
D
-----
E
-
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
--
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
--
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
-
11
PsiBlast_PDB
81.70
49%
-91
- C2 -
3II9
3
?
A:
[10-395]
-----------
D
D
P
L
L
L
---
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
E
T
T
D
A
A
-
I
F
R
E
M
----
G
E
I
G
L
L
G
P
----
T
I
P
E
-
Q
Y
G
G
P
-
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
-------
S
-
M
V
T
R
A
-
R
K
--
V
P
-
G
G
--
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
D
EDG
R
-----
D
-----
E
-
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
--
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
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T
L
G
L
Q
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V
L
R
L
G
R
M
K
D
E
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T
A
A
V
E
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T
--
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
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G
I
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D
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G
V
A
R
H
L
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N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
-
105
HHSearch
81.49
49%
-95
- C2 -
1SIQ
1
GCDH_HUMAN
A:
[3-388]
---------
D
W
Q
D
P
L
V
L
---
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
--
R
N
E
V
F
H
-
R
--
E
I
I
S
E
M
G
E
L
G
V
L
G
P
----
T
I
-
K
-
G
Y
G
C
A
-
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
-
S
-
M
E
T
R
A
-
H
Y
NS
S
N
-
K
S
--
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
E
D--------
G
-----
C
-
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
--
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
--
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
-
39
PsiBlast_CBE
81.16
49%
-88
- C2 -
3GQT
1
?
C:
[13-398]
-----------
D
D
P
L
L
L
---
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
E
T
T
D
A
A
-
I
F
R
E
M
----
G
E
I
G
L
L
G
P
----
T
I
P
E
-
Q
Y
G
G
P
-
G
L
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
G
S
D
P
G
-
S
-
M
V
T
R
A
-
R
K
--
V
P
-
G
G
--
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
D
E
DG
R
-----
D
-----
E
-
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
--
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
--
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
------
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
-
5
PsiBlast_PDB
80.61
48%
-92
- C2 -
2R0N
2
GCDH_HUMAN
A:
[3-390]
-------
E
F
D
W
Q
D
P
L
V
L
---
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
--
L
L
--
A
N
R
N
E
V
-
F
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
----
T
I
-
K
-
G
Y
G
C
A
-
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
-
S
-
M
E
T
R
A
-
H
Y
--
N
S
-
S
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
E
---------
D
-----
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
--
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
--
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
-
4
PsiBlast_PDB
80.42
48%
-95
- C2 -
1SIR
2
GCDH_HUMAN
A:
[3-390]
-------
E
F
D
W
Q
D
P
L
V
L
---
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
--
L
L
--
A
N
R
N
E
V
-
F
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
----
T
I
-
K
-
G
Y
G
C
A
-
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
-
S
-
M
E
T
R
A
-
H
Y
--
N
S
-
S
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
E
---------
D
-----
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
--
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
--
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
-
8
PsiBlast_PDB
79.86
48%
-94
- C2 -
1SIQ
1
GCDH_HUMAN
A:
[2-388]
--------
F
D
W
Q
D
P
L
V
L
---
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
--
L
L
--
A
N
R
N
E
V
-
F
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
----
T
I
-
K
-
G
Y
G
C
A
-
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
-
S
-
M
E
T
R
A
-
H
Y
--
N
S
-
S
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
E
---------
D
-----
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
--
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
--
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
-
6
PsiBlast_PDB
79.23
48%
-93
- C2 -
2R0M
2
GCDH_HUMAN
A:
[3-390]
-------
E
F
D
W
Q
D
P
L
V
L
---
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
--
L
L
--
A
N
R
N
E
V
-
F
H
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
----
T
I
-
K
-
G
Y
G
C
A
-
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
-
S
-
M
E
T
R
A
-
H
Y
--
N
S
-
S
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
E
---------
D
-----
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
--
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
--
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
D
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
-
85
PsiBlast_CBE
70.50
33%
-80
- C2 -
2D29
2
?
A:
[2-381]
---------------
G
L
---
W
F
E
E
G
A
E
E
R
Q
V
L
G
P
F
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
--
R
T
G
A
F
P
-
W
--
D
L
V
R
K
L
A
E
F
G
V
F
G
A
----
L
V
P
E
-
A
Y
G
G
A
-
G
L
S
T
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
S
L
A
T
G
H
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
-
A
-
L
K
T
K
A
-
E
K
--
V
E
-
G
G
--
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
PPPSPERKH
Q
-----
G
-
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G-
E
R
G
-
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
P
F
T
L
E
A
--
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
---------
84
PsiBlast_CBE
70.32
33%
-84
- C2 -
2D29
2
?
B:
[2-381]
---------------
G
L
---
W
F
E
E
G
A
E
E
R
Q
V
L
G
P
F
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
--
R
T
G
A
F
P
-
W
--
D
L
V
R
K
L
A
E
F
G
V
F
G
A
----
L
V
P
E
-
A
Y
G
G
A
-
G
L
S
T
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
S
L
A
T
G
H
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
-
A
-
L
K
T
K
A
-
E
K
--
V
E
-
G
G
--
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
PPPSPERKH
Q
-----
G
-
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G-
E
R
G
-
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
P
F
T
L
E
A
--
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
---------
75
PsiBlast_CBE
69.33
34%
-87
- C2 -
2DVL
2
?
A:
[3-368]
-----------------------
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
--
R
K
A
E
Y
P
-
W
P
Q
--
L
K
A
L
A
E
L
G
L
L
G
M
----
T
T
-
P
-
E
E
W
G
G
V
G
L
D
S
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
-
S
-
L
R
A
E
A
-
R
R
--
V
K
-
G
G
--
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
---------
K
-----
G
-
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G-
E
E
G
-
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
--
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
---------
56
PsiBlast_CBE
67.42
35%
-83
- C2 -
1JQI
4
ACADS_RAT
B:
[17-378]
------------------------------
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
--
K
E
H
L
F
P
-
T
S
Q
--
V
K
K
M
G
E
L
G
L
L
A
M
----
D
V
-
P
-
E
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
-
A
-
A
S
T
T
A
-
R
E
--
E
G
-
D
S
--
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
RSRQN----
K
-----
G
-
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
GE
P
G
--
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
--
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
-----------
74
PsiBlast_CBE
67.38
34%
-86
- C2 -
2DVL
2
?
B:
[3-368]
-----------------------
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
--
R
K
A
E
Y
P
-
W
P
Q
--
L
K
A
L
A
E
L
G
L
L
G
M
----
T
T
-
P
-
E
E
W
G
G
V
G
L
D
S
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
-
S
-
L
R
A
E
A
-
R
R
--
V
K
-
G
G
--
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
---------
K
-----
G
-
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G-
E
E
G
-
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
--
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
---------
18
PsiBlast_PDB
67.01
35%
-81
- C2 -
1JQI
4
ACADS_RAT
A:
[17-378]
------------------------------
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
--
K
E
H
L
F
P
-
T
S
Q
--
V
K
K
M
G
E
L
G
L
L
A
M
----
D
V
-
P
-
E
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
-
A
-
A
S
T
T
A
-
R
E
--
E
G
-
D
S
--
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
RSRQN----
K
-----
G
-
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
GE
P
G
--
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
--
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
-----------
93
Fugue
66.38
32%
-84
- C2 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
----------------
M
---
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
--
H
K
G
I
Y
D
---
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
YFEE
K
Y
-
G
-
G
S
G
D
D
-
G
G
D
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
-
G
-
Q
Q
T
I
A
-
T
K
--
N
D
D
G
T
--
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
KSKGN----
H
-----
G
-
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
--
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
F
T
V
D
A
--
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-----
67
PsiBlast_CBE
64.19
31%
-84
- C2 -
4L1F
7
?
A:
[1-376]
----------------
M
---
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
----
R
D
K
A
H
I
-
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
----
C
F
P
E
-
E
Y
G
G
M
-
G
L
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
-
A
-
Q
Q
T
T
A
-
V
L
--
K
G
-
D
K
--
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
---------
K
SQGVH
G
-
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G-
K
E
G
-
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
--
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
--------
66
PsiBlast_CBE
64.13
31%
-83
- C2 -
4L1F
5
?
B:
[1-376]
----------------
M
---
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
----
R
D
K
A
H
I
-
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
----
C
F
P
E
-
E
Y
G
G
M
-
G
L
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
-
A
-
Q
Q
T
T
A
-
V
L
--
K
G
-
D
K
--
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
---------
K
SQGVH
G
-
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G-
K
E
G
-
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
--
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
--------
69
PsiBlast_CBE
55.33
35%
-84
- C2 -
1BUC
3
ACDS_MEGEL
A:
[70-381]
------------------------------------------------------------------------------------------------
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
-
G
-
Q
Q
T
I
A
T
K
N
--
D
D
-
G
T
--
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
---------
K
SKGNH
G
-
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G-
E
E
G
-
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
-
V
Y
K
A
A
C
K
K
Q
E
G
-
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
-------
68
PsiBlast_CBE
54.72
35%
-81
- C2 -
1BUC
3
ACDS_MEGEL
B:
[70-381]
------------------------------------------------------------------------------------------------
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
-
G
-
Q
Q
T
I
A
T
K
N
--
D
D
-
G
T
--
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
---------
K
SKGNH
G
-
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G-
E
E
G
-
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
-
V
Y
K
A
A
C
K
K
Q
E
G
-
K
P
F
T
V
DA
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
-------