@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0425c: (2016-04-22 )
MPVRAVATGFRATATLTGASITAATAVSATLAKTGVGTGMKVAIIPLRAGAKALSGELSRETLGRNCWRGERRAWIEVRGLRSGGDDELGRVVLNAIQAHPGVGSASLNYPLSRVVVAIDDPDTSLRELCRIVDDAEKAERHRHPDQAADQLAQSPGSLPGDGVLLAVRAVTVAATAAGLGLALGGRALRWPRFPLVIEAAVAAVDHQPLLRRLLEDRIGTEATATVLELAMAAAHTVTLSPAALSVDLTIQALKAAECRAGARAWRRHEPQLALHADEPADQPQSLWPRPARSTQPVQRSVARFALIQALSAVLVGAGTRDADMAATATLVATPKASRTTPEAFAAALGQGLADQHAVLPLRPESLRRLDRVDAIVIDPRVLCTDDLRVARIRGCGADELSTAWNRAQLVLTESGLRPGWHRVPGVSASGSDSAVEALFRPMHDRLASAVVAEAHRTGADLVSVDVDALGELRPVFDDIRPLDDGASGSLDEALARAVAELRQAGRTVAVLSSVGKQALSAADVALGVLPPPGAGAPPWYADVLLPDLGAAWRVLHAIPAARAARQRGNEISGGASALGALLMLPGVRGLGPGPVTTGAAAGLLSGYLLARKVVDAQAPRPAPAHEWHAMSVEQVRKALPSPDEQAPAKAPPSPYPARALAGGLHTAKRGAQITQAPLNALWQLTKAMRAELSDPLTPMLALGAMASAVLGSPVDAVMVGSVLTGNSILAASQRLRAESRLNRLLAQQIPPARKVLAGADDQPRYIEVRAEELRPGDIIEVRTHEVVPADARVIEEVDVEVDESALTGESLSVTKQVEPTPGVDLIERRCMLYAGTTVVSGTAVAVVTAVGPDTQERRAAELVSGDLSSVGLQHQLSRLTNQAWPVSMTGGALVTGLGLLRRRGLRQAVASGIAVTVAAVPEGMPLVATLAQQASARRLSHFGALVRIPRSVEALGRVDMVCFDKTGTLSENRLRVAQVRPVAGHSREEVLRCAAHAAPASNGPQVHATDVAIVQAAAAAAASGTDGAEPGAAEPAAHLPFRSGRSFSASVSGTELTVKGAPEVVLAACEGIGSSMDDAVAELAANGLRVIAVAHRQLTAQQAQSVVDDPDEIARLCRDELSLVGFLGLSDTPRAQAAALLADLHEHDLDIRLITGDHPITAAAIAEELGMQVSPEQVISGAEWDALSRKDQERAVAERVIFARMTPENKVQIVQTLEHSGRVCAMVGDGSNDAAAIRAATVGIGVVAHGSDPARVAADLVLVDGRIESLLPAILEGRQLWQRVQAAVSVLLGGNAGEVAFAIIGSAITGTSPLNTRQLLLVNMLTDALPAAALAVSKPSDPVTPATRGPDQRELWRAVGIRGATTAAAATVAWVMAGFTGLPRRASTVALVALVAAQLGQTLVDSHAWLVVLTALGSLAALATLISIPVVSQLLGCTPLDPLGWAQATAAATAATVAVAVLNRVLTGRDKSGQPNPQPPETDALSRDASPGAPPGPRRRRRATARRKAPVKAPSATRQTTKPKGPPAHRSSSTYPRR
Atome Classification :
(43 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640-.-......650.......660.......670.......680.......-690.......700.......--710-------------.......720.......730.......740....---...750.......760.......770.......780.......790....--.--..800.......810.......820-.--.......830.......840.......850.....-..860....-...870.......880.......890.......900----------.------.----.....910.......920.......930.......940.......950.......960.......970.......980----------..-------------------....--------------------------------.------------------------------------..990-----------.........1000--------..-------------.....------.-------------1010......1020.--...--------------..1030..--------------....1040......1050.----------..----------...1060......1070----------...-------------.-------------.-------------.---...1080----------..--.--...1090......-1100.-.....1110......1120......1130......1140......1150......1160......1170-----------------------....------------------------..----.----1180......--1190.......--.1200........1210......1220......1230......1240......1250......1260......1270......1280......1290......1300-........1310......1320......1330......-1340...-....-----1350......-1360------......1370--......1380------------------------------------..-------------------------------------......1390......1400..------------..------------..1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPV
R
A
V
ATGF
R
A
T
A
T
LTGA
S
I
T
A
A
T
A
V
S
A
T
L
A
KTGVGTG
M
K
V
A
I
I
P
LRAG
A
K
A
LS
G
E
L
S
R
E
T
LGRNCWRGE
R
R
A
W
I
E
V
R
GLRSG
G
D
D
E
L
G
R
V
V
L
N
A
I
QAHPGVGSASLNYP
L
S
R
V
V
V
A
IDDP
D
T
S
L
R
E
L
C
R
I
VD
D
A
E
K
A
E
R
HRH
P
D
Q
A
A
D
Q
L
A
QSPGSLPGD
G
V
L
L
A
V
R
A
V
T
V
A
A
T
AAG
L
G
L
ALGGRALRWPRF
P
L
V
I
E
A
A
V
A
AV
D
H
Q
P
L
L
R
R
L
L
E
D
RIG
T
E
A
T
A
T
V
L
E
L
A
M
A
AA
H
T
V
T
LSP
A
A
L
S
V
D
L
T
I
Q
A
L
K
A
A
E
C
R
A
G
A
R
A
W
RRHEP
Q
L
A
L
HADEPADQPQSLWPRPARST
Q
P
V
Q
R
S
V
A
R
F
A
L
I
Q
A
L
S
A
V
L
VGAGTRD
A
D
M
A
A
T
A
T
L
V
ATPKASRT
T
P
E
A
F
A
A
A
L
GQGLADQHAVLPL
R
P
E
S
L
R
R
L
DRV
D
A
I
V
IDP
R
V
L
CTDD
L
R
V
A
R
IRGCG
A
D
E
L
S
T
AWN
R
A
Q
L
V
L
TESGLRPGWHRVPGVSASGS
D
S
A
V
E
A
L
F
R
P
M
H
D
R
L
A
S
A
V
V
A
E
A
HRTGA
D
L
V
S
V
D
V
D
A
L
G
E
L
R
P
V
F
D
DIRPLDDGASG
S
L
D
E
A
L
A
R
A
V
A
E
L
R
QAG
R
T
V
A
V
L
S
S
V
G
K
Q
A
L
S
A
A
D
V
A
L
G
VLPPPGAGAPP
W
Y
A
D
V
LLP
D
L
G
A
A
W
R
V
L
H
AI
P
A
A
R
A
A
R
QRGNEISG
G
A
S
A
L
G
A
L
L
MLPGVRGLGPGPV
T
T
G
A
A
A
G
L
L
S
G
Y
L
L
A
R
K
V
VDAQAPRPAPAHEWHAM
S
V
E
Q
V
R
K
ALPS-P-DEQAPAKAPPSPY
P
A
R
A
L
AGG
L
H
T
A
KRGAQ
I
T
Q
A
P
L
N
A
L
W
Q
L
T
K
A
M
-
R
A
E
LSDP
L
T
P
M
L
A
L
G
A
M
A
S
A
--
V
LG-------------SP
V
D
A
V
MVGSVLTG
N
S
I
L
A
A
S
Q
R
L
R
A
E
S
R
L
N
R
L
L
---
A
Q
QIP
P
A
R
K
VLAGADDQP
R
Y
I
E
V
R
A
E
ELRPG
D
I
I
E
V
R
THEVVPA
D
A
R
V
I
E
--E--VDVEVDESALTGES
L
S
V
T
KQVEPT--P--
G
V
D
L
I
E
R
R
C
M
L
Y
AG
T
T
V
VSG
T
A
V
A
V
V
T
AVGP
D
T
Q
E
-
R
R
A
A
E
L
V
SG-
D
L
S
S
V
G
L
Q
H
Q
L
S
R
L
TNQAW
P
V
SMTG
G
A
L
V
T
G
L
G
L
L
R
----------
R
------
R
----
G
L
R
Q
A
V
ASG
I
A
V
T
V
AAVPEG
M
P
L
V
A
T
L
A
Q
Q
A
S
A
R
R
L
S
H
F
G
A
L
V
RI
P
R
S
V
E
ALGRV
D
M
V
C
FDKTGTLSEN
R
L
R
V
A
Q
V------------RP-------------------VAGH--------------------------------
S
------------------------------------
R
E
E
-------------
V
L
R
C
A
AHAAPA----------SN-------------GP
Q
V
H
------A-------------
T
D
V
A
I
V
Q
A
A
A
A
AAAS--GTD--------------GAEPGAAE--------------PAAHLPFRSGR
S
F
SASVSG----------
T
E
----------
L
T
VKGA
P
E
V
V
L
A
A
C
-------------
E
GI-------------G-------------S-------------
S
---
M
D
D
A
V
A
E
----------
L
A
--A--N
G
L
R
V
I
A
V
A
H
R
Q
L
-
T
A
Q
Q
A
-
Q
S
VVD
D
P
D
E
I
A
R
L
C
R
D
E
L
S
L
V
G
F
LGLSDT
P
R
A
Q
A
A
A
L
L
A
D
L
H
EHD
L
D
I
R
L
I
TGDHP
I
T
A
A
A
I
A
E
E
LGM------------------------QV
S
P
------------------------
E
Q
----
V
----ISGAE
W
D
A
LS--
R
K
--
D
Q
E
R
A
V
A
--
E
R
--
V
I
F
A
RMTPEN
K
V
Q
I
V
Q
T
L
EHSG
R
V
C
A
M
VGDGSNDA
A
A
I
R
A
A
T
V
G
I
G
V
V
AHGS
D
P
A
R
V
A
A
D
L
V
L
VD
G
R
I
E
S
L
L
P
A
I
L
E
G
R
Q
L
W
Q
R
V
Q
A
A
V
S
V
L
LGGNA
G
E
V
A
---
F
A
IIGSAITGTSPLN
T
R
Q
L
L
L
V
N
M
L
T
DA
L
P
A
A
A
LAVSK-P-SDPVT-PATR-----GP
D
Q
R
E
L
W
R
A
-VGIR------GA
T
T
A
A
A
A
T
V
--
A
W
V
M
A
GF-T-------------------------------------GL-------------------------------------PR
R
A
S
T
V
A
L
V
A
L
V
A
A
Q
L
G
Q
T
L
V
------------DS------------H
A
W
L
V
V
L
T
A
L
G
S
L
A
A
L
A
T
L
I
S
I
P
V
V
S
Q
L
LGCTPLDPLGW
A
Q
A
T
A
A
A
T
A
A
T
V
A
V
A
V
L
N
R
V
LTGRDKSGQPNPQPPETDALSRDASPGAPPG
P
R
R
R
R
R
A
TARRKAPVKAPSATRQTTKPKGPPAHRSSSTYPRR
127
Fugue
91.49
24%
-74
- C2 -
1SU4
3
AT2A1_RABIT
A:
[1-994]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
-
S
-
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
----
I
E
Q
F
E
D
L
L
-
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
E
G
EE
T
I
T
-------------
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
---
E
Y
E
P
E
M
G
-
K
V
Y
R
--
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
IK
S
--
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
PD
P
--
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
-
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
FNDPVHGGSW
I
------
R
----
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
------------
F
I
-------------------
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
YAP
E
G
E
V
L
K
ND
K
P
I
R
S
G
------------------------------------
Q
F
D
-------------
G
L
V
E
L
A
T
I
C
A
L
----------
C
N
-------------
D
S
S
L
D
------
F
NETKG
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
--
N
T
E
--------------
V
R
N
L
S
K
V
E
RAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
----------
P
A
KSSRAAVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
-------------
R
V
GT
T
R
V
P
MT
G
P
V
K
E
-------------
K
---
I
L
S
V
I
K
E
----------
W
G
--
T
GR
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
-
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
VADR
A
----
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
-
D
L
D
I
M
-
D
R
P
P
-----
R
S
P
K
E
P
L
I
S
G
-
W
L
F
F
------
R
Y
M
A
I
G
G
Y
V
G
--
A
A
T
V
G
A
A
-
A
-------------------------------------
W
W
F
MYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFE
A
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
LSENQSLMRMP
P
W
------------
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
------------------------------------------------------------------
104
HHSearch
86.78
23%
-60
- C1 -
2ZXE
6
?
A:
[43-1019]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
D
L
-
T
R
G
L
T
N
A
R
A
K
E
I
L
A
R
-----------
D
G
P
N
S
L
--
T
P
P
P
T
T
P
E
W
I
K
F
-
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
--
L
A
Y
G
I
Q
A
A
TEDEPAN
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
---
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
-----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
---
E
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
------------
W
F
-------------------
D
N
Q
I
H
E
A
DTTENQSGAAFDKTS
A
-------------
T
------------------------------------
W
S
A
-------------
L
S
R
I
A
-
A
L
C
N
R
----------
A
V
F
Q
A
GQDNVPILKR
S
V
A
G
D
------
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
--
V
Q
----------------
G
M
R
D
R
N
P
--------------
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
NEKSSES
R
--
Y
L
----------
L
V
M
K
G
A
P
E
R
I
L
D
R
C
-------------
S
T
I
-------------
L
-------------
L
NG
A
E
E
P
LK
E
D
M
K
E
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
-
P
E
D
K
Y
-
N
E
G
Y
P
F
D
A
D
E
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
------------------------
I
S
E
G
NET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
----
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
--
V
L
D
D
I
L
H
Y
H
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
---
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
-
A
-
E
S
D
I
M
K
R
Q
P
R
NPKTD
K
L
V
N
E
R
L
I
S
M
A
Y
G
Q
I
------
G
M
I
Q
A
L
G
G
F
F
--
S
Y
F
V
I
L
A
-
E
N
GFLPMDLIGK
R
V
R
W
D
DRWIS
D
V
E
D
SFG
Q
Q
W
T
Y
E
Q
R
K
I
V
-------------------------------------
E
F
T
C
H
T
S
F
F
I
S
I
V
V
V
Q
W
A
D
L
I
I
------------
C
K
TRRNSIFQQGM-
K
N
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
C
P
G
T
D
V
A
L
R
M
Y
P
L
K
P
S
W
W
F
C
A
F
P
Y
S
L
I
I
F
L
Y
D
E
M
R
R
F
I
I
R
R
S
P
G
-------------------------------------------------------------------
126
Fugue
86.41
23%
-57
- C2 -
3B8E
6
AT1A1_PIG
A:
[1-998]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
T
-
D
-
L
S
R
G
L
T
P
A
R
A
A
E
I
L
A
R
D
G
P
N
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
R
Q
L
F
G
G
F
S
M
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
T
E
E
E
P
--
Q
N
D
-------------
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
----
K
N
M
V
P
Q
Q
A
L
V
I
R
N
----
G
E
K
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
-----
N
E
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
E
------
Y
----
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
------------
W
S
DN
Q
I
H
E
A
DTTENQSGVSFD
K
T
S
A
--------------------------------
T
------------------------------------
W
L
A
-------------
L
S
R
I
A
G
L
C
N
R
A
V
F
Q
A
NQENLP
I
L
-------------
K
R
A
V
A
------
G
-------------
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
--
G
S
V
--------------
K
E
M
R
E
R
Y
T
--------------
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
K
----------
N
P
NTAEPR
H
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
-------------
S
S
I
L
I
HGKEQPLDEEL
K
-------------
D
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
L
F
L
-
P
D
E
Q
F
-
P
E
G
F
Q
F
D
T
D
D
V
N
F
P
L
D
N
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGN
E
T
V
E
D
IAARLNIPVSQVNP
R
D
A
K
------------------------
A
C
----
V
----
V
H
G
S
D
L
K
D
M
T
--
S
E
--
Q
L
D
D
I
L
K
--
Y
H
TE
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
---
P
F
L
I
F
I
I
A
N
I
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
-
A
E
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
V
N
E
-
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
--
T
Y
F
V
I
L
A
-
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRK
I
V
-------------------------------------
E
F
T
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQ-
G
M
------------
K
N
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
C
P
G
M
G
V
A
L
R
M
Y
P
L
K
P
T
W
W
F
C
A
F
P
Y
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
R
P
G
G
W
V
E
K
E
T
Y
Y
----------------------------------------------------------
106
HHSearch
81.96
25%
-14
- C1 -
3AR4
8
AT2A1_RABIT
A:
[4-994]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
-
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
-----------
Y
G
H
N
E
L
--
P
A
E
E
G
K
S
L
W
E
L
V
-
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
--
V
L
A
W
F
EEGEETIT---
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
---
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
---
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
--
I
KS
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
--
P
DP
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
-
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
----------
F
NDPVHG
G
S
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
------------
F
I
-------------------
I
D
K
V
--------------------------------
D
GD
F
C
S
L
N
E
F
S
I
T
G
STYAPE
G
E
V
L
K
ND
K
P
I
R
SGQF
D
G
L
V
E
-------------
L
A
T
-
I
C
A
L
C
N
D
----------
S
S
L
D
F
NETKG
V
Y
---
E
K
V
G
E
------
A
-------------
T
E
T
A
L
T
T
L
V
E
K
M
N
V
F
--
N
T
E
VRNLS
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
K
--------------
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
AKSSRAA
V
G
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
-------------
R
-------------
V
GT
T
R
V
P
MT
G
P
V
K
E
K
---
I
L
S
V
I
K
E
----------
W
G
TG
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
-
L
D
D
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
EEVA--------------------
D
R
----
A
----
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
S
-
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
-
D
L
D
I
M
D
R
P
P
R
SPKE-
P
L
I
S
G
W
L
F
F
R
-
Y
M
A
I
------
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
GPGVTYHQLTHFMQCTEDHPHFEGLDCEI--------
F
E
-------------------------------------
A
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
------------
S
L
SENQSLMRMPPW
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
-------------------------------------------------------------------
3
PsiBlast_PDB
80.61
25%
-62
- C1 -
4HQJ
6
AT1A1_PIG
A:
[110-842]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
E
E
-------------
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
N
G
E
K
----
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
-----
N
E
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
E
------
Y
----
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
WSDN
Q
I
H
E
A
D
TT
E
N
-------------------
Q
S
G
V
--------------------------------
S
------------------------------------
F
D
K
TS
A
T
W
L
A
L
S
R
I
A
G
L
C
N
R
A
V
F
Q
A
N
Q
----------
E
N
-------------
L
P
I
L
K
R
A
V
A
G
D
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
--
V
K
E
--------------
M
R
E
--
R
Y
T
--------------
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
K
----------
N
P
NTAEP
R
H
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
HG
K
E
Q
P
L
D
E
E
L
-------------
K
-------------
D
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
L
F
L
-
P
D
E
Q
F
P
E
G
F
Q
F
D
T
D
D
V
-
N
F
P
L
D
N
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
V
E
D
I
A
A
R
L
NIPVS----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
M
T
--
S
E
Q
L
D
D
I
L
K
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
---
P
F
L
I
F
I
I
A
N
I
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.08
25%
-63
- C1 -
4XE5
4
?
A:
[110-842]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
E
E
-------------
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
N
G
E
K
----
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
-----
N
E
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
E
------
Y
----
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
-
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
V
--------------------------------
S
------------------------------------
F
D
K
TS
A
T
W
L
A
L
S
R
I
A
G
L
C
N
R
A
V
F
Q
A
N
Q
----------
D
N
-------------
L
P
I
L
K
RAVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
V
C
C
G
S
--
V
K
E
--------------
M
R
E
--
R
Y
T
--------------
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
K
----------
N
A
NAGEP
R
H
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
HG
K
E
Q
P
L
D
E
E
L
-------------
K
-------------
D
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
L
L
L
-
P
D
E
Q
F
P
E
G
F
Q
F
D
T
D
D
V
-
N
F
P
V
D
N
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
V
E
D
I
A
A
R
L
NIPVS----
Q
V
N
P
------------------------
R
D
AR
A
C
V
----
V
H
G
S
D
L
K
D
M
T
P
E
Q
L
--
D
D
I
L
K
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
---
P
F
L
I
F
I
I
A
N
I
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
Q
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.06
25%
-64
- C1 -
3WGU
11
AT1A1_PIG
A:
[105-837]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
E
E
-------------
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
N
G
E
K
----
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
-----
N
E
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
E
------
Y
----
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
WFDN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
V
--------------------------------
S
------------------------------------
F
D
K
TS
A
T
W
L
A
L
S
R
I
A
G
L
C
N
R
A
V
F
Q
A
N
Q
----------
E
N
-------------
L
P
I
L
K
R
A
V
A
G
D
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
--
V
K
E
--------------
M
R
E
--
R
Y
T
--------------
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
K
----------
N
P
NTAEPR
H
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
HG
K
E
Q
P
LD
E
E
L
-------------
K
-------------
D
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
L
F
L
-
P
D
E
Q
F
P
E
G
F
Q
F
D
T
D
D
V
-
N
F
P
L
D
N
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
V
E
D
I
A
A
R
L
NIPVS----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
M
T
--
S
E
Q
L
D
D
I
L
K
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
---
P
F
L
I
F
I
I
A
N
I
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.55
25%
-65
- C1 -
3WGV
12
AT1A1_PIG
A:
[105-837]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
E
E
-------------
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
N
G
E
K
----
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
-----
N
E
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
E
------
Y
----
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
WFDN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
V
--------------------------------
S
------------------------------------
F
D
K
TS
A
T
W
L
A
L
S
R
I
A
G
L
C
N
R
A
V
F
Q
A
N
Q
----------
E
N
-------------
L
P
I
L
K
R
A
V
A
G
D
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
--
V
K
E
--------------
M
R
E
--
R
Y
T
--------------
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
K
----------
N
P
NTAEPR
H
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
HGKEQPLD
E
E
L
-------------
K
-------------
D
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
L
F
L
-
P
D
E
Q
F
P
E
G
F
Q
F
D
T
D
D
V
-
N
F
P
L
D
N
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
V
E
D
I
A
A
R
L
NIPVS----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
M
T
--
S
E
Q
L
D
D
I
L
K
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
---
P
F
L
I
F
I
I
A
N
I
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
78.62
26%
-61
- C1 -
5AVS
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.46
26%
-61
- C1 -
5AVZ
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.37
26%
-61
- C1 -
5AVW
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.35
26%
-61
- C1 -
5AW0
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.33
26%
-61
- C1 -
5AVU
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.33
26%
-61
- C1 -
5AVT
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.33
26%
-61
- C1 -
5AVR
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.24
26%
-61
- C1 -
5AVV
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.23
26%
-61
- C1 -
2ZXE
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.19
26%
-61
- C1 -
5AVQ
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
78.16
26%
-61
- C1 -
5AVX
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.15
26%
-61
- C1 -
5AVY
5
?
A:
[117-849]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
Y
G
I
Q
A
A
T
--
E
D
E
-------------
P
A
N
D
N
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
K
S
T
----
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
F
S
--
S
--
E
-
N
P
L
E
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
-
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
----------
G
------
Y
----
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
DN
Q
I
H
E
A
DTT
E
N
-------------------
Q
S
G
A
--------------------------------
A
------------------------------------
F
D
K
TS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
G
Q
----------
D
N
-------------
V
P
I
L
K
RSVAGD
A
-------------
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
--------------
D
R
N
P
K
I
V
E
------------------
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
----------
N
E
KSSES
R
Y
L
--
L
V
M
K
G
A
P
E
R
I
L
D
R
C
STILLNG
A
E
E
P
LK
E
D
M
-------------
K
-------------
E
-------------
A
---
F
Q
N
A
Y
L
E
----------
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
P
E
D
K
Y
N
-
E
G
Y
P
F
D
A
D
E
-
P
N
F
P
T
T
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGNET
I
E
D
I
A
A
R
L
NIPIG----
Q
V
N
P
------------------------
R
D
AK
A
C
V
----
V
H
G
S
D
L
K
D
L
S
--
T
E
V
L
D
D
I
L
H
Y
H
--
T
E
--
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
---
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
-
S
D
I
M
K
-
R
Q
P
R
-----
N
P
K
T
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
55.65
31%
-56
- C1 -
2C8K
4
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
RV-----------
G
-------------
T
-------------
T
RVP
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
55.62
31%
-53
- C1 -
2O9J
3
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
55.19
31%
-48
- C1 -
4H1W
4
AT2A1_RABIT
A:
[509-815]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
RV-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADR
A
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
55.05
31%
-54
- C1 -
4XOU
5
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
RV-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
54.70
31%
-54
- C1 -
3N8G
5
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
54.31
31%
-51
- C1 -
3TLM
5
AT2A1_BOVIN
A:
[508-816]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
T
K
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
D
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
T
H
K
S
K
I
V
E
Y
L
Q
S
F
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
54.21
31%
-49
- C1 -
3FPB
4
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
54.07
31%
-51
- C1 -
2OA0
1
AT2A1_RABIT
A:
[509-818]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
RV-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
53.78
31%
-54
- C1 -
1T5S
5
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
53.61
31%
-51
- C1 -
2BY4
5
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
RV-----------
G
-------------
T
-------------
T
RVP
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
53.37
31%
-56
- C1 -
1T5T
6
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
53.33
31%
-54
- C1 -
2C88
4
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
RV-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
52.64
31%
-55
- C1 -
3W5B
4
AT2A1_RABIT
A:
[515-818]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
RV-----------
G
-------------
T
-------------
T
RVP
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
52.63
31%
-50
- C1 -
3FPS
1
AT2A1_RABIT
A:
[509-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
37.27
31%
19
- C1 -
3AR8
5
AT2A1_RABIT
A:
[512-813]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
36.79
31%
22
- C1 -
3AR2
6
?
A:
[512-813]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADR
A
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
36.28
31%
20
- C1 -
3AR3
5
?
A:
[512-813]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
36.25
31%
19
- C1 -
3AR4
6
AT2A1_RABIT
A:
[512-813]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
36.16
31%
21
- C1 -
2DQS
5
AT2A1_RABIT
A:
[512-813]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
36.03
31%
23
- C1 -
3BA6
5
AT2A1_RABIT
A:
[511-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADR
A
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
35.55
31%
18
- C1 -
4UU1
7
AT2A1_RABIT
A:
[512-813]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
RV-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
35.22
31%
19
- C1 -
4UU0
6
AT2A1_RABIT
A:
[512-813]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
35.13
31%
20
- C1 -
2ZBD
6
?
A:
[512-813]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------
N
K
----------
M
F
V
K
G
A
P
E
G
V
I
D
R
C
-------------
N
Y
V
R
V
-----------
G
-------------
T
-------------
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
--
R
--
D
T
L
R
C
L
A
L
A
T
R
D
T
-
P
P
K
R
E
-
E
M
V
L
D
D
S
S
R
F
M
E
Y
E
T
D
-
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------
F
G
E
N
------------------------
E
E
----
V
ADRA
Y
T
G
R
E
F
D
D
L
P
--
L
A
--
E
Q
R
E
A
C
R
--
R
A
--
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
---
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------