@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0429c: (2016-04-22 )
MAVVPIRIVGDPVLHTATTPVTVAADGSLPADLAQLIATMYDTMDAANGVGLAANQIGCSLRLFVYDCAADRAMTARRRGVVINPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRAKWARVTGLDADGSPVSIEGTGLFARMLQHETGHLDGFLYLDRLIGRYARNAKRAVKSHGWGVPGLSWLPGEDPDPFGH
Atome Classification :
(90 SA)
.........10........20........30........40.....-...50........60......--------..70...-----....---.80---.....-....90........100.-----......110.......120.......130.......140.......150.......160..-.....170.......180.......190.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
V
V
P
I
R
I
VGDPVLHTATT
P
V
T
V
AADGS
L
P
A
D
L
A
Q
L
I
A
T
M
Y
D
T
MDA-ANGVGL
A
A
N
QIG
C
S
L
R
L
F
V
Y
D--------CAAD
R
A
M
-----
T
ARR---R
G
----
V
V
I
NP-VLETSEIPETMPDPDTDD-----EGCLSVPGESFPTGRA
K
W
A
R
VTGLDADG
S
P
V
S
I
E
G
T
G
L
F
A
R
M
L
Q
H
ETGHL
D
G
F
L
Y
L
D
R
L
I
G
-
R
Y
A
R
N
A
K
R
A
V
K
SHGWGVPGLSWLPGEDPDPFGH
101
HHSearch
98.90
100%
-108
- C5 -
3E3U
4
DEF_MYCTU
A:
[2-197]
-
A
V
V
P
I
R
I
V
G
D
P
V
L
H
T
A
T
T
P
V
T
V
A
A
D
G
S
L
P
A
D
L
A
Q
L
I
A
T
M
Y
D
T
M
D
A
-
A
N
G
V
G
L
A
A
N
Q
I
G
C
S
L
R
L
F
V
Y
D
--------
C
A
A
D
R
A
M
-----
T
A
R
R
---
R
G
----
V
V
I
N
P
-
V
L
E
T
S
E
I
P
E
T
M
P
D
P
D
T
D
D
-----
E
G
C
L
S
V
P
G
E
S
F
P
T
G
R
A
K
W
A
R
V
T
G
L
D
A
D
G
S
P
V
S
I
E
G
T
G
L
F
A
R
M
L
Q
H
E
T
G
H
L
D
G
F
L
Y
L
D
R
L
I
G
-
R
Y
A
R
N
A
K
R
A
V
K
S
H
G
W
G
V
P
G
L
S
W
L
P
G
E
D
P
D
P
F
G
H
1
PsiBlast_PDB
98.90
100%
-108
- C5 -
3E3U
4
DEF_MYCTU
A:
[2-197]
-
A
V
V
P
I
R
I
V
G
D
P
V
L
H
T
A
T
T
P
V
T
V
A
A
D
G
S
L
P
A
D
L
A
Q
L
I
A
T
M
Y
D
T
M
D
A
-
A
N
G
V
G
L
A
A
N
Q
I
G
C
S
L
R
L
F
V
Y
D
--------
C
A
A
D
R
A
M
-----
T
A
R
R
---
R
G
----
V
V
I
N
P
-
V
L
E
T
S
E
I
P
E
T
M
P
D
P
D
T
D
D
-----
E
G
C
L
S
V
P
G
E
S
F
P
T
G
R
A
K
W
A
R
V
T
G
L
D
A
D
G
S
P
V
S
I
E
G
T
G
L
F
A
R
M
L
Q
H
E
T
G
H
L
D
G
F
L
Y
L
D
R
L
I
G
-
R
Y
A
R
N
A
K
R
A
V
K
S
H
G
W
G
V
P
G
L
S
W
L
P
G
E
D
P
D
P
F
G
H
3
PsiBlast_PDB
66.25
37%
-99
- C5 -
1N5N
3
DEF_PSEAE
A:
[13-176]
M
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
V
D
D
A
-----
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
-
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-----
P
R
-----------
V
F
I
N
P
-
E
F
E
P
--
L
T
E
E
M
---
D
Q
Y
Q
-----
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
R
D
R
I
R
K
K
L
E
K
Q
H
--------------------
23
PsiBlast_CBE
66.07
37%
-93
- C5 -
1N5N
2
DEF_PSEAE
B:
[14-176]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
V
D
D
A
-----
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
-
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-----
P
R
-----------
V
F
I
N
P
-
E
F
E
P
--
L
T
E
E
M
---
D
Q
Y
Q
-----
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
R
D
R
I
R
K
K
L
E
K
Q
H
--------------------
113
HHSearch
65.04
37%
-87
- C5 -
3QU1
6
DEF2_VIBCH
A:
[4-165]
M
A
V
L
E
I
L
T
A
P
D
P
R
L
R
V
Q
S
K
Q
V
T
D
------
V
A
S
V
Q
T
L
I
D
D
L
L
D
T
L
Y
A
T
D
N
G
I
G
L
A
A
P
Q
V
G
R
E
E
A
I
V
V
I
D
--------
L
S
D
N
R
---------
D
Q
---
P
L
----
V
L
I
N
P
-
K
V
V
S
G
S
-----
N
-
K
E
M
G
Q
-----
E
G
C
L
S
V
P
D
Y
Y
A
D
V
E
R
Y
T
S
V
V
V
E
A
L
D
R
E
G
K
P
L
R
I
E
T
S
D
F
L
A
I
V
M
Q
H
E
I
D
H
L
S
G
N
L
F
I
D
Y
L
S
P
-
L
K
Q
Q
M
A
M
K
K
V
K
K
H
--------------------
4
PsiBlast_PDB
64.69
37%
-93
- C5 -
1S17
3
DEF_PSEAE
A:
[14-176]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
V
D
D
A
-----
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
-
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-----
P
R
-----------
V
F
I
N
P
-
E
F
E
P
--
L
T
E
E
M
---
D
Q
Y
Q
-----
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
R
D
R
I
R
K
K
L
E
K
Q
H
--------------------
22
PsiBlast_CBE
64.37
37%
-96
- C5 -
1S17
2
DEF_PSEAE
B:
[14-176]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
V
D
D
A
-----
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
-
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-----
P
R
-----------
V
F
I
N
P
-
E
F
E
P
--
L
T
E
E
M
---
D
Q
Y
Q
-----
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
R
D
R
I
R
K
K
L
E
K
Q
H
--------------------
103
HHSearch
64.29
32%
-93
- C5 -
4WXK
2
DEF_HAEI8
A:
[3-162]
--
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
V
-----
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
-
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
--------
V
E
G
D
K
---------
Q
N
---
Q
F
----
V
L
I
N
P
-
E
I
L
A
S
E
------
G
E
T
G
I
E
-----
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
-
L
K
R
Q
R
I
K
E
K
L
I
K
Y
--------------------
5
PsiBlast_PDB
64.26
37%
-98
- C5 -
1LRY
2
DEF_PSEAE
A:
[1-163]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
V
D
D
A
-----
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
-
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-----
P
R
-----------
V
F
I
N
P
-
E
F
E
----
P
L
T
-
E
D
M
D
Q
Y
Q
-----
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
R
D
R
I
R
K
K
L
E
K
Q
H
--------------------
106
HHSearch
64.17
37%
-87
- C5 -
1N5N
3
DEF_PSEAE
A:
[13-174]
M
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
V
-----
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
-
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
---------
S
E
---
P
R
----
V
F
I
N
P
-
E
F
E
P
L
T
-----
E
E
M
D
Q
Y
Q
-----
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
-
L
K
R
D
R
I
R
K
K
L
E
K
---------------------
84
PsiBlast_CBE
63.91
32%
-105
- C5 -
4WXK
2
DEF_HAEI8
A:
[3-147]
--
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
V
N
D
A
-----
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
-
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
--------
V
E
G
D
K
---------
Q
N
---
Q
F
----
V
L
I
N
P
-
E
I
L
A
S
E
G
E
T
G
I
------
E
-----
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
------------------------------------
32
PsiBlast_CBE
63.63
34%
-102
- C5 -
4AL2
2
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
65
PsiBlast_CBE
63.62
34%
-93
- C5 -
1BS5
3
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
60
PsiBlast_CBE
63.62
34%
-94
- C5 -
1BS7
3
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
33
PsiBlast_CBE
63.59
34%
-101
- C5 -
4AL2
2
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
38
PsiBlast_CBE
63.30
34%
-92
- C5 -
1XEN
7
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
13
PsiBlast_PDB
63.19
34%
-95
- C5 -
2W3T
3
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
111
HHSearch
62.77
33%
-87
- C5 -
2W3T
3
DEF_ECOLI
A:
[1-159]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
---------
D
E
---
R
L
----
V
L
I
N
P
-
E
L
L
E
K
S
-----
G
-
E
T
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
-
L
K
Q
Q
R
I
R
Q
K
V
E
----------------------
67
PsiBlast_CBE
62.72
34%
-90
- C5 -
1BS4
4
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
44
PsiBlast_CBE
62.67
34%
-93
- C5 -
1ICJ
4
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
2
PsiBlast_PDB
62.61
38%
-88
- C5 -
1IX1
4
DEF_PSEAE
A:
[2-164]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
V
D
D
A
-----
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
-
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-----
P
R
-----------
V
F
I
N
P
-
E
F
E
----
P
L
T
-
E
D
M
D
Q
Y
Q
-----
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
R
D
R
I
R
K
K
L
E
K
Q
H
--------------------
66
PsiBlast_CBE
62.34
34%
-92
- C5 -
1BS4
4
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
47
PsiBlast_CBE
62.20
34%
-94
- C5 -
1G2A
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
43
PsiBlast_CBE
62.19
34%
-90
- C5 -
1ICJ
4
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
124
Fugue
62.17
32%
-84
- C5 -
1G2A
2
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
---------
D
E
---
R
L
----
V
L
I
N
P
-
E
L
L
E
K
S
------
G
E
T
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
-
L
K
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
-----------------
6
PsiBlast_PDB
62.07
34%
-100
- C5 -
3K6L
2
DEF_ECOLI
A:
[2-147]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
48
PsiBlast_CBE
62.05
34%
-96
- C5 -
1G27
2
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
16
PsiBlast_PDB
61.85
34%
-96
- C5 -
4AL2
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
37
PsiBlast_CBE
61.80
34%
-93
- C5 -
1XEO
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
107
HHSearch
61.77
32%
-92
- C5 -
3U04
4
?
A:
[3-183]
M
S
V
L
S
I
V
T
V
P
D
K
R
L
S
L
C
S
E
E
V
E
K
V
-----
D
Q
S
I
R
K
L
V
D
D
M
F
E
T
M
H
A
-
N
Q
G
L
G
L
A
A
V
Q
V
G
V
H
K
R
I
L
V
M
N
--------
V
P
E
E
---IEGYE
L
Y
G
G
---
P
Y
----
C
I
I
N
P
-
K
I
V
D
I
S
-----
Q
E
K
V
K
L
K
-----
E
G
C
L
S
V
P
G
Y
F
D
Y
I
V
R
P
Q
R
I
A
V
Q
Y
L
D
Y
N
G
N
E
C
I
I
K
A
Q
G
W
L
A
R
C
L
Q
H
E
I
D
H
L
N
G
T
V
F
L
K
Y
L
S
K
-
F
K
R
D
F
A
I
E
K
V
K
K
---------------------
52
PsiBlast_CBE
61.76
34%
-94
- C5 -
1BSZ
4
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
120
HHSearch
61.72
34%
-98
- C5 -
4DR8
4
?
A:
[16-185]
K
P
P
L
D
L
H
Y
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
I
-----
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
-
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
--------
L
E
L
E
D
E
-------
Q
A
P
---
P
L
----
V
L
I
N
P
-
K
I
E
R
T
A
-----
G
D
L
E
Q
C
Q
-----
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
-
R
L
E
L
N
--
E
A
L
D
K
K
G
F
A
V
Q
A
V
-------------
18
PsiBlast_PDB
61.58
34%
-93
- C5 -
1BS4
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
77
PsiBlast_CBE
61.54
32%
-102
- C5 -
4WXL
2
DEF_HAEI8
D:
[3-147]
--
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
V
N
D
A
-----
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
-
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
--------
V
E
G
D
K
---------
Q
N
---
Q
F
----
V
L
I
N
P
-
E
I
L
A
S
E
G
E
T
G
I
------
E
-----
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
------------------------------------
21
PsiBlast_CBE
61.46
38%
-88
- C5 -
1IX1
4
DEF_PSEAE
B:
[2-164]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
V
D
D
A
-----
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
-
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-----
P
R
-----------
V
F
I
N
P
-
E
F
E
----
P
L
T
-
E
D
M
D
Q
Y
Q
-----
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
R
D
R
I
R
K
K
L
E
K
Q
H
--------------------
63
PsiBlast_CBE
61.31
34%
-93
- C5 -
1BS6
4
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
49
PsiBlast_CBE
61.22
34%
-95
- C5 -
1G27
2
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
39
PsiBlast_CBE
61.05
34%
-91
- C5 -
1XEM
11
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
102
HHSearch
61.01
32%
-85
- C5 -
1XEO
2
DEF_ECOLI
A:
[1-165]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
---------
D
E
---
R
L
----
V
L
I
N
P
-
E
L
L
E
K
S
-----
G
-
E
T
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
-
L
K
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
----------------
35
PsiBlast_CBE
60.90
34%
-95
- C5 -
2AI8
2
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
62
PsiBlast_CBE
60.64
34%
-94
- C5 -
1BS6
4
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
46
PsiBlast_CBE
60.59
34%
-95
- C5 -
1G2A
2
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
17
PsiBlast_PDB
60.57
34%
-91
- C5 -
1ICJ
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
25
PsiBlast_CBE
60.53
34%
-101
- C5 -
3K6L
2
DEF_ECOLI
B:
[2-147]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
36
PsiBlast_CBE
60.48
34%
-92
- C5 -
2AI8
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
51
PsiBlast_CBE
60.44
34%
-92
- C5 -
1BSZ
4
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
82
PsiBlast_CBE
60.43
32%
-101
- C5 -
4WXK
2
DEF_HAEI8
C:
[1-147]
M
T
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
V
N
D
A
-----
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
-
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
--------
V
E
G
D
K
---------
Q
N
---
Q
F
----
V
L
I
N
P
-
E
I
L
A
S
E
G
E
T
G
I
------
E
-----
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
------------------------------------
34
PsiBlast_CBE
60.41
34%
-91
- C5 -
2AI8
2
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
14
PsiBlast_PDB
60.30
34%
-92
- C5 -
2W3U
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
123
Fugue
60.23
31%
-82
- C5 -
1BS4
2
DEF_ECOLI
A:
[1-168]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
-
E
L
L
E
K
S
------
G
E
T
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
-
L
K
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
A
-------------
29
PsiBlast_CBE
60.14
34%
-91
- C5 -
4DR8
3
?
D:
[24-185]
--------
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
I
D
D
-----
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
-
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
--------
L
E
L
E
D
E
Q
-----
A
P
P
L
---------
V
L
I
N
P
-
K
I
E
-----
R
T
A
G
D
L
E
Q
C
Q
-----
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
-
R
L
E
L
N
--
E
A
L
D
K
K
G
F
A
V
Q
A
V
-------------
57
PsiBlast_CBE
60.08
34%
-95
- C5 -
1BS8
4
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
55
PsiBlast_CBE
60.07
34%
-93
- C5 -
1BSJ
3
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
41
PsiBlast_CBE
60.05
34%
-92
- C5 -
1LRU
4
DEF_ECOLI
B:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
81
PsiBlast_CBE
60.04
32%
-94
- C5 -
4WXK
3
DEF_HAEI8
D:
[2-147]
-
T
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
V
N
D
A
-----
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
-
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
--------
V
E
G
D
K
---------
Q
N
---
Q
F
----
V
L
I
N
P
-
E
I
L
A
S
E
G
E
T
G
I
------
E
-----
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
------------------------------------
26
PsiBlast_CBE
60.03
34%
-93
- C5 -
4DR9
4
?
D:
[24-185]
--------
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
I
D
D
-----
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
-
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
--------
L
E
L
E
D
E
Q
-----
A
P
P
L
---------
V
L
I
N
P
-
K
I
E
-----
R
T
A
G
D
L
E
Q
C
Q
-----
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
-
R
L
E
L
N
--
E
A
L
D
K
K
G
F
A
V
Q
A
V
-------------
83
PsiBlast_CBE
59.97
32%
-97
- C5 -
4WXK
2
DEF_HAEI8
B:
[3-147]
--
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
V
N
D
A
-----
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
-
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
--------
V
E
G
D
K
---------
Q
N
---
Q
F
----
V
L
I
N
P
-
E
I
L
A
S
E
G
E
T
G
I
------
E
-----
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
------------------------------------
31
PsiBlast_CBE
59.93
34%
-89
- C5 -
4DR8
5
?
B:
[24-185]
--------
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
I
D
D
-----
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
-
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
--------
L
E
L
E
D
E
Q
-----
A
P
P
L
---------
V
L
I
N
P
-
K
I
E
-----
R
T
A
G
D
L
E
Q
C
Q
-----
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
-
R
L
E
L
N
--
E
A
L
D
K
K
G
F
A
V
Q
A
V
-------------
11
PsiBlast_PDB
59.87
34%
-92
- C5 -
4AZ4
2
?
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
54
PsiBlast_CBE
59.79
34%
-94
- C5 -
1BSK
3
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
99
PsiBlast_CBE
59.74
34%
-92
- C5 -
1VEV
3
DEF_LEPIN
B:
[1-157]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
--
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
-
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
--------
S
E
D
N
E
R
Y
-----
P
G
T
P
DVP
E
R
----
I
I
L
N
P
-
V
I
T
----------
P
L
T
K
D
TSGFW
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
------------------------------------
53
PsiBlast_CBE
59.57
34%
-91
- C5 -
1BSZ
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
45
PsiBlast_CBE
59.54
34%
-92
- C5 -
1G2A
2
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
56
PsiBlast_CBE
59.48
34%
-92
- C5 -
1BS8
4
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
50
PsiBlast_CBE
59.46
34%
-93
- C5 -
1G27
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
79
PsiBlast_CBE
59.27
32%
-98
- C5 -
4WXL
2
DEF_HAEI8
B:
[5-147]
----
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
V
N
D
A
-----
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
-
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
--------
V
E
G
D
K
---------
Q
N
---
Q
F
----
V
L
I
N
P
-
E
I
L
A
S
E
G
E
T
G
I
------
E
-----
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
------------------------------------
28
PsiBlast_CBE
59.18
34%
-89
- C5 -
4DR9
5
?
B:
[24-185]
--------
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
I
D
D
-----
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
-
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
--------
L
E
L
E
D
E
Q
-----
A
P
P
L
---------
V
L
I
N
P
-
K
I
E
-----
R
T
A
G
D
L
E
Q
C
Q
-----
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
-
R
L
E
L
N
--
E
A
L
D
K
K
G
F
A
V
Q
A
V
-------------
40
PsiBlast_CBE
59.13
34%
-92
- C5 -
1LRU
2
DEF_ECOLI
C:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
58
PsiBlast_CBE
58.85
34%
-91
- C5 -
1BS8
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
98
PsiBlast_CBE
58.72
34%
-89
- C5 -
1VEY
2
DEF_LEPIN
A:
[1-157]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
--
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
-
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
--------
S
E
D
N
E
R
Y
-----
P
G
T
P
D
V
P
E
R
----
I
I
L
N
P
-
V
I
T
----------
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
------------------------------------
20
PsiBlast_PDB
58.67
34%
-95
- C5 -
1BS6
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
100
PsiBlast_CBE
58.55
34%
-94
- C5 -
1VEV
4
DEF_LEPIN
A:
[1-157]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
--
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
-
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
--------
S
E
D
N
E
R
Y
-----
P
G
T
P
DV
P
E
R
----
I
I
L
N
P
-
V
I
T
----------
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
------------------------------------
27
PsiBlast_CBE
58.36
34%
-94
- C5 -
4DR9
5
?
C:
[24-185]
--------
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
I
D
D
-----
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
-
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
--------
L
E
L
E
D
E
Q
-----
A
P
P
L
---------
V
L
I
N
P
-
K
I
E
-----
R
T
A
G
D
L
E
Q
C
Q
-----
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
-
R
L
E
L
N
--
E
A
L
D
K
K
G
F
A
V
Q
A
V
-------------
30
PsiBlast_CBE
58.22
34%
-91
- C5 -
4DR8
3
?
C:
[24-185]
--------
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
I
D
D
-----
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
-
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
--------
L
E
L
E
D
E
Q
-----
A
P
P
L
---------
V
L
I
N
P
-
K
I
E
-----
R
T
A
G
D
L
E
Q
C
Q
-----
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
-
R
L
E
L
N
--
E
A
L
D
K
K
G
F
A
V
Q
A
V
-------------
42
PsiBlast_CBE
58.09
34%
-93
- C5 -
1LRU
2
DEF_ECOLI
A:
[1-146]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
E
N
R
D
---------
E
---
R
L
----
V
L
I
N
P
E
L
L
E
K
S
--
G
E
T
-----
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
------------------------------------
96
PsiBlast_CBE
57.99
34%
-86
- C5 -
1VEZ
9
DEF_LEPIN
A:
[1-157]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
--
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
-
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
--------
S
E
D
N
E
R
Y
-----
P
G
T
P
DV
P
E
R
----
I
I
L
N
P
-
V
I
T
----------
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
------------------------------------
93
PsiBlast_CBE
57.94
34%
-88
- C5 -
1Y6H
6
DEF_LEPIN
B:
[1-157]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
--
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
-
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
--------
S
E
D
N
E
R
Y
-----
P
G
T
P
DVP
E
R
----
I
I
L
N
P
-
V
I
T
----------
P
L
T
K
D
TSGFW
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
------------------------------------
95
PsiBlast_CBE
57.86
34%
-88
- C5 -
1VEZ
8
DEF_LEPIN
B:
[1-157]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
--
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
-
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
--------
S
E
D
N
E
R
Y
-----
P
G
T
P
DVP
E
R
----
I
I
L
N
P
-
V
I
T
----------
P
L
T
K
D
TSGFW
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
------------------------------------
9
PsiBlast_PDB
57.70
34%
-94
- C5 -
4DR8
4
?
A:
[24-185]
--------
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
I
D
D
-----
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
-
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
--------
L
E
L
E
D
E
Q
-----
A
P
P
L
---------
V
L
I
N
P
-
K
I
E
-----
R
T
A
G
D
L
E
Q
C
Q
-----
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
-
R
L
E
L
N
--
E
A
L
D
K
K
G
F
A
V
Q
A
V
-------------
97
PsiBlast_CBE
57.34
34%
-88
- C5 -
1VEY
2
DEF_LEPIN
B:
[1-157]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
--
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
-
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
--------
S
E
D
N
E
R
Y
-----
P
G
T
P
DVP
E
R
----
I
I
L
N
P
-
V
I
T
----------
P
L
T
K
D
TSGFW
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
------------------------------------
78
PsiBlast_CBE
57.03
32%
-93
- C5 -
4WXL
3
DEF_HAEI8
C:
[2-147]
-
T
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
V
N
D
A
-----
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
-
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
--------
V
E
G
D
K
---------
Q
N
---
Q
F
----
V
L
I
N
P
-
E
I
L
A
S
E
G
E
T
G
I
------
E
-----
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
------------------------------------
94
PsiBlast_CBE
56.92
34%
-93
- C5 -
1Y6H
5
DEF_LEPIN
A:
[1-157]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
--
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
-
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
--------
S
E
D
N
E
R
Y
-----
P
G
T
P
D
V
P
E
R
----
I
I
L
N
P
-
V
I
T
----------
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
------------------------------------
80
PsiBlast_CBE
56.71
32%
-98
- C5 -
4WXL
3
DEF_HAEI8
A:
[3-147]
--
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
V
N
D
A
-----
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
-
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
--------
V
E
G
D
K
---------
Q
N
---
Q
F
----
V
L
I
N
P
-
E
I
L
A
S
E
G
E
T
G
I
------
E
-----
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
------------------------------------
122
Fugue
55.55
31%
-79
- C5 -
1G2A
2
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
-----
E
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
-
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
--------
V
S
-
E
N
R
------
D
--
E
---
R
L
----
V
L
I
N
P
-
E
L
L
E
K
S
------
G
E
T
G
I
E
-----
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
---
P
L
K
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
---------------
105
HHSearch
55.28
31%
-82
- C5 -
3UWB
4
?
A:
[2-150]
--
S
L
K
I
K
T
I
G
D
R
C
L
R
Q
K
S
E
E
V
E
F
D
-----
K
K
E
M
S
E
L
Y
D
Q
M
C
E
A
M
W
A
-
S
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
R
V
I
V
V
D
--------
E
T
T
E
E
H
-------
G
K
Y
---
A
H
----
L
M
V
N
P
-
K
I
T
W
K
S
-----
E
E
K
V
L
F
D
-----
E
G
C
L
S
V
P
D
Q
N
G
E
V
L
R
P
K
S
I
K
V
T
F
Q
N
K
D
G
K
Y
K
K
W
K
L
D
G
L
A
A
R
V
V
Q
H
E
I
D
H
L
E
G
I
L
F
V
D
Y
F
N
-----------------------------------
71
PsiBlast_CBE
53.10
34%
-78
- C5 -
1ZY1
2
DEF1A_ARATH
A:
[10-189]
---------
G
D
P
V
L
H
E
K
A
R
E
V
D
P
G
E
I
G
S
--
E
R
I
Q
K
I
I
D
D
M
I
K
V
M
R
L
-
A
P
G
V
G
L
A
A
P
Q
I
G
V
P
L
R
I
I
V
L
E
D
T
K
E
Y
I
S
Y
A
P
K
E
E
I
L
-----
A
Q
E
R
---
R
H
F
D
L
M
V
M
V
N
P
-
V
L
K
E
R
S
N
K
K
A
L
F
F
----------
E
G
C
L
S
V
D
G
F
R
A
A
V
E
R
Y
L
E
V
V
V
T
G
Y
D
R
Q
G
K
R
I
E
V
N
A
S
G
W
Q
A
R
I
L
Q
H
E
C
D
H
L
D
G
N
L
Y
V
D
K
M
V
P
-
R
T
F
R
T
V
D
N
L
D
L
P
L
A
E
G
C
P
K
L
-------------
108
HHSearch
53.04
33%
-75
- C5 -
1Y6H
5
DEF_LEPIN
A:
[1-172]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
E
D
E
I
--
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
-
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
--------
S
E
D
N
E
R
Y
PG
T
--
P
D
V
P
---
E
R
----
I
I
L
N
P
-
V
I
T
P
L
T
-----
K
D
T
S
G
F
W
-----
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
-
T
K
L
F
G
F
N
E
T
L
D
S
S
--------------------
86
PsiBlast_CBE
52.40
33%
-84
- C5 -
4JE8
2
DEF1A_ARATH
A:
[10-189]
---------
G
D
P
V
L
H
E
K
A
R
E
V
D
P
G
E
I
G
S
--
E
R
I
Q
K
I
I
D
D
M
I
K
V
M
R
L
-
A
P
C
V
G
L
A
A
P
Q
I
G
V
P
L
R
I
I
V
L
E
D
T
K
E
Y
I
S
Y
A
P
K
E
E
I
L
-----
A
Q
E
R
---
R
H
F
D
L
M
V
M
V
N
P
-
V
L
K
E
R
S
N
K
K
A
L
F
F
----------
E
G
C
E
S
V
D
G
F
R
A
A
V
E
R
Y
L
E
V
V
V
T
G
Y
D
R
Q
G
K
R
I
E
V
N
A
S
G
W
Q
A
R
I
L
Q
H
E
C
D
H
L
D
G
N
L
Y
V
D
K
M
V
P
-
R
T
F
R
T
V
D
N
L
D
L
P
L
A
E
G
C
P
K
L
-------------
70
PsiBlast_CBE
51.38
34%
-77
- C5 -
1ZY1
2
DEF1A_ARATH
B:
[10-189]
---------
G
D
P
V
L
H
E
K
A
R
E
V
D
P
G
E
I
G
S
--
E
R
I
Q
K
I
I
D
D
M
I
K
V
M
R
L
-
A
P
G
V
G
L
A
A
P
Q
I
G
V
P
L
R
I
I
V
L
E
DTKEYISY
A
P
K
E
E
I
L
-----
A
Q
E
R
---
R
H
FDLM
V
M
V
N
P
-
V
L
K
E
R
S
N
K
K
A
L
F
F
----------
E
G
C
L
S
V
D
G
F
R
A
A
V
E
R
Y
L
E
V
V
V
T
G
Y
D
R
Q
G
K
R
I
E
V
N
A
S
G
W
Q
A
R
I
L
Q
H
E
C
D
H
L
D
G
N
L
Y
V
D
K
M
V
P
-
R
T
F
R
T
V
D
N
L
D
L
P
L
A
E
G
C
P
K
L
-------------
85
PsiBlast_CBE
50.30
33%
-77
- C5 -
4JE8
2
DEF1A_ARATH
B:
[10-189]
---------
G
D
P
V
L
H
E
K
A
R
E
V
D
P
G
E
I
G
S
--
E
R
I
Q
K
I
I
D
D
M
I
K
V
M
R
L
-
A
P
C
V
G
L
A
A
P
Q
I
G
V
P
L
R
I
I
V
L
E
D
T
K
E
Y
I
S
Y
A
P
K
E
E
I
L
-----
A
Q
E
R
---
R
H
F
D
L
M
V
M
V
N
P
-
V
L
K
E
R
S
N
K
K
A
L
F
F
----------
E
G
C
E
S
V
D
G
F
R
A
A
V
E
R
Y
L
E
V
V
V
T
G
Y
D
R
Q
G
K
R
I
E
V
N
A
S
G
W
Q
A
R
I
L
Q
H
E
C
D
H
L
D
G
N
L
Y
V
D
K
M
V
P
-
R
T
F
R
T
V
D
N
L
D
L
P
L
A
E
G
C
P
K
L
-------------