@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0440: (2016-04-22 )
MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150-.......160.......170.....-..180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430........440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKTIAY
D
E
E
A
R
R
G
L
E
R
G
L
N
A
L
A
D
A
V
K
V
TLGPKG
R
N
V
V
L
E
KKWGAPTITNDGVS
I
A
K
E
IELED
P
Y
E
K
I
G
A
E
L
V
K
E
V
A
K
KTDDVAGDG
T
T
T
A
T
V
L
A
Q
A
L
V
R
E
G
L
R
N
V
AAGAN
P
L
G
L
K
R
G
I
E
K
A
V
E
K
V
T
E
T
L
L
K
G
A
K
E
V
E
T
K
E
Q
I
A
A
T
AAISAG-D
Q
S
I
G
D
L
I
A
E
A
M
D
KVGNE
G
V
I
T
V
EE-SN
T
F
G
L
Q
L
E
LTEGMRFDKGYIS
G
Y
F
VTD
P
E
R
Q
E
A
VLED
P
Y
I
L
L
VSS
K
V
S
T
V
K
D
L
L
P
L
L
E
K
V
IGAGK
P
L
L
I
I
AEDVEG
E
A
L
S
T
L
V
V
N
K
I
R
G
T
F
K
S
V
A
VKAPGF
G
D
R
R
K
A
M
L
Q
D
M
A
I
LTGG
Q
V
I
S
E
EV
G
L
T
L
ENA
D
L
S
L
LGKA
R
K
V
V
V
TKDE
T
T
I
V
EGAG
D
T
D
A
I
A
G
R
V
A
Q
I
R
Q
E
IENSDSDY
D
R
E
K
L
Q
E
R
L
A
K
LAG
G
V
A
V
I
KAGAAT
E
V
E
L
K
E
R
K
H
R
I
E
D
A
V
R
N
A
K
A
A
V
E
EGIVAGG
G
V
T
L
L
QAAP
T
L
D
E
LKLEG-DEATGA
N
I
V
K
V
A
L
EA
P
L
K
Q
I
A
F
NSGLE
P
G
V
V
A
E
K
V
R
NLPAGHGLNAQ
T
G
V
Y
E
D
L
L
A
AGVA
D
P
V
K
V
T
R
S
A
L
Q
N
A
A
S
I
A
G
L
F
L
T
T
E
A
VVADKPEKEKASVPGGGDMGGMDF
2
PsiBlast_PDB
92.32
100%
-97
- C4 -
1SJP
-
CH602_MYCTU
A:
[60-514]
------------------------------------------------------------
L
E
D
P
Y
E
K
I
G
A
E
L
V
K
E
V
A
K
K
T
--------
T
T
A
T
V
L
A
Q
A
L
V
R
E
G
L
R
N
V
A
A
G
A
N
P
L
G
L
K
R
G
I
E
K
A
V
E
K
V
T
E
T
L
L
K
G
A
K
E
V
E
T
K
E
Q
I
A
A
T
A
A
I
S
A
G
-
D
Q
S
I
G
D
L
I
A
E
A
M
D
K
V
G
N
E
G
V
I
T
V
E
E
-
S
N
T
F
G
L
Q
L
E
L
T
E
G
M
R
F
D
K
G
Y
I
S
G
Y
F
V
T
D
P
E
R
Q
E
A
V
L
E
D
P
Y
I
L
L
V
S
S
K
V
S
T
V
K
D
L
L
P
L
L
E
K
V
I
G
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
S
T
L
V
V
N
K
I
R
G
T
F
K
S
V
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
M
A
I
L
T
G
G
Q
V
I
S
E
E
V
G
L
T
L
E
N
A
D
L
S
L
L
G
K
A
R
K
V
V
V
T
K
D
E
T
T
I
V
E
G
A
G
D
T
D
A
I
A
G
R
V
A
Q
I
R
Q
E
I
E
N
S
D
S
D
Y
D
R
E
K
L
Q
E
R
L
A
K
L
A
G
G
V
A
V
I
K
A
G
A
A
T
E
V
E
L
K
E
R
K
H
R
I
E
D
A
V
R
N
A
K
A
A
V
E
E
G
I
V
A
G
G
G
V
T
L
L
Q
A
A
P
T
L
D
E
L
K
L
E
G
-
D
E
A
T
G
A
N
I
V
K
V
A
L
E
A
P
L
K
Q
I
A
F
N
S
G
L
E
P
G
V
V
A
E
K
V
R
N
L
P
A
G
H
G
L
N
A
Q
T
G
V
Y
E
D
L
L
A
A
G
V
A
D
P
V
K
V
T
R
S
A
L
Q
N
A
A
S
I
A
G
L
F
L
T
T
E
-------------------------
1
PsiBlast_PDB
89.03
100%
-90
- C4 -
3RTK
1
CH602_MYCTU
A:
[61-515]
------------------------------------------------------------
L
E
D
P
Y
E
K
I
G
A
E
L
V
K
E
V
A
K
K
T
D
-------
T
T
A
T
V
L
A
Q
A
L
V
R
E
G
L
R
N
V
A
A
G
A
N
P
L
G
L
K
R
G
I
E
K
A
V
E
K
V
T
E
T
L
L
K
G
A
K
E
V
E
T
K
E
Q
I
A
A
T
A
A
I
S
A
G
-
D
Q
S
I
G
D
L
I
A
E
A
M
D
K
V
G
N
E
G
V
I
T
V
E
E
-
S
N
T
F
G
L
Q
L
E
L
T
E
G
M
R
F
D
K
G
Y
I
S
G
Y
F
V
T
D
P
E
R
Q
E
A
V
L
E
D
P
Y
I
L
L
V
S
S
K
V
S
T
V
K
D
L
L
P
L
L
E
K
V
I
G
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
S
T
L
V
V
N
K
I
R
G
T
F
K
S
V
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
M
A
I
L
T
G
G
Q
V
I
S
E
E
V
G
L
T
L
E
N
A
D
L
S
L
L
G
K
A
R
K
V
V
V
T
K
D
E
T
T
I
V
E
G
A
G
D
T
D
A
I
A
G
R
V
A
Q
I
R
Q
E
I
E
N
S
D
S
D
Y
D
R
E
K
L
Q
E
R
L
A
K
L
A
G
G
V
A
V
I
K
A
G
A
A
T
E
V
E
L
K
E
R
K
H
R
I
E
D
A
V
R
N
A
K
A
A
V
E
E
G
I
V
A
G
G
G
V
T
L
L
Q
A
A
P
T
L
D
E
L
K
L
E
G
-
D
E
A
T
G
A
N
I
V
K
V
A
L
E
A
P
L
K
Q
I
A
F
N
S
G
L
E
P
G
V
V
A
E
K
V
R
N
L
P
A
G
H
G
L
N
A
Q
T
G
V
Y
E
D
L
L
A
A
G
V
A
D
P
V
K
V
T
R
S
A
L
Q
N
A
A
S
I
A
G
L
F
L
T
T
E
-------------------------
189
HHSearch
88.49
99%
-91
- C4 -
3RTK
1
CH602_MYCTU
A:
[61-515]
------------------------------------------------------------
L
E
D
P
Y
E
K
I
G
A
E
L
V
K
E
V
A
K
K
T
D
-------
T
T
A
T
V
L
A
Q
A
L
V
R
E
G
L
R
N
V
A
A
G
A
N
P
L
G
L
K
R
G
I
E
K
A
V
E
K
V
T
E
T
L
L
K
G
A
K
E
V
E
T
K
E
Q
I
A
A
T
A
A
I
S
A
G
-
D
Q
S
I
G
D
L
I
A
E
A
M
D
K
V
G
N
E
G
V
I
T
V
E
E
S
N
T
F
G
-
L
Q
L
E
L
T
E
G
M
R
F
D
K
G
Y
I
S
G
Y
F
V
T
D
P
E
R
Q
E
A
V
L
E
D
P
Y
I
L
L
V
S
S
K
V
S
T
V
K
D
L
L
P
L
L
E
K
V
I
G
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
S
T
L
V
V
N
K
I
R
G
T
F
K
S
V
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
M
A
I
L
T
G
G
Q
V
I
S
E
E
V
G
L
T
L
E
N
A
D
L
S
L
L
G
K
A
R
K
V
V
V
T
K
D
E
T
T
I
V
E
G
A
G
D
T
D
A
I
A
G
R
V
A
Q
I
R
Q
E
I
E
N
S
D
S
D
Y
D
R
E
K
L
Q
E
R
L
A
K
L
A
G
G
V
A
V
I
K
A
G
A
A
T
E
V
E
L
K
E
R
K
H
R
I
E
D
A
V
R
N
A
K
A
A
V
E
E
G
I
V
A
G
G
G
V
T
L
L
Q
A
A
P
T
L
D
E
L
K
L
E
G
-
D
E
A
T
G
A
N
I
V
K
V
A
L
E
A
P
L
K
Q
I
A
F
N
S
G
L
E
P
G
V
V
A
E
K
V
R
N
L
P
A
G
H
G
L
N
A
Q
T
G
V
Y
E
D
L
L
A
A
G
V
A
D
P
V
K
V
T
R
S
A
L
Q
N
A
A
S
I
A
G
L
F
L
T
T
E
-------------------------
72
PsiBlast_CBE
87.10
59%
-78
- C4 -
1XCK
1
CH60_ECOLI
B:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------
82
PsiBlast_CBE
86.78
59%
-77
- C4 -
1MNF
3
CH60_ECOLI
E:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------
61
PsiBlast_CBE
86.72
59%
-78
- C4 -
1XCK
2
CH60_ECOLI
M:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------
12
PsiBlast_PDB
86.63
59%
-77
- C4 -
2NWC
-
CH60_ECOLI
A:
[3-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------
59
PsiBlast_CBE
86.59
59%
-78
- C4 -
3E76
6
CH60_ECOUT
B:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------
78
PsiBlast_CBE
86.58
59%
-77
- C4 -
1MNF
3
CH60_ECOLI
I:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------
74
PsiBlast_CBE
86.55
59%
-76
- C4 -
1MNF
2
CH60_ECOLI
M:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------
77
PsiBlast_CBE
86.51
59%
-77
- C4 -
1MNF
3
CH60_ECOLI
J:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------
85
PsiBlast_CBE
86.41
59%
-77
- C4 -
1MNF
3
CH60_ECOLI
B:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------
67
PsiBlast_CBE
86.41
59%
-76
- C4 -
1XCK
2
CH60_ECOLI
G:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------
73
PsiBlast_CBE
86.39
59%
-76
- C4 -
1MNF
2
CH60_ECOLI
N:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------
68
PsiBlast_CBE
86.37
59%
-76
- C4 -
1XCK
77
CH60_ECOLI
F:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------
64
PsiBlast_CBE
86.37
59%
-76
- C4 -
1XCK
2
CH60_ECOLI
J:
[2-524]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
------------------
84
PsiBlast_CBE
86.36
59%
-77
- C4 -
1MNF
3
CH60_ECOLI
C:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------
7
PsiBlast_PDB
86.33
59%
-76
- C4 -
1MNF
3
CH60_ECOLI
A:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------
81
PsiBlast_CBE
86.32
59%
-77
- C4 -
1MNF
3
CH60_ECOLI
F:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
P
K
G
R
N
V
V
L
D
K
S
F
G
A
P
T
I
T
K
D
G
V
S
V
A
R
E
I
E
L
E
D
K
F
E
N
M
G
A
Q
M
V
K
E
V
A
S
K
A
N
D
A
A
G
D
G
T
T
T
A
T
V
L
A
Q
A
I
I
T
E
G
L
K
A
V
A
A
G
M
N
P
M
D
L
K
R
G
I
D
K
A
V
T
A
A
V
E
E
L
K
A
L
S
V
P
C
S
D
S
K
A
I
A
Q
V
G
T
I
S
A
N
S
D
E
T
V
G
K
L
I
A
E
A
M
D
K
V
G
K
E
G
V
I
T
V
E
D
-
G
T
G
L
Q
D
E
L
D
V
V
E
G
M
Q
F
D
R
G
Y
L
S
P
Y
F
I
N
K
P
E
T
G
A
V
E
L
E
S
P
F
I
L
L
A
D
K
K
I
S
N
I
R
E
M
L
P
V
L
E
A
V
A
K
A
G
K
P
L
L
I
I
A
E
D
V
E
G
E
A
L
A
T
L
V
V
N
T
M
R
G
I
V
K
V
A
A
V
K
A
P
G
F
G
D
R
R
K
A
M
L
Q
D
I
A
T
L
T
G
G
T
V
I
S
E
E
I
G
M
E
L
E
K
A
T
L
E
D
L
G
Q
A
K
R
V
V
I
N
K
D
T
T
T
I
I
D
G
V
G
E
E
A
A
I
Q
G
R
V
A
Q
I
R
Q
Q
I
E
E
A
T
S
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
K
V
G
A
A
T
E
V
E
M
K
E
K
K
A
R
V
E
D
A
L
H
A
T
R
A
A
V
E
E
G
V
V
A
G
G
G
V
A
L
I
R
V
A
S
K
L
A
D
L
R
G
Q
N
E
D
Q
N
V
G
I
K
V
A
L
R
A
M
E
A
P
L
R
Q
I
V
L
N
C
G
E
E
P
S
V
V
A
N
T
V
K
G
G
D
G
N
Y
G
Y
N
A
A
T
E
E
Y
G
N
M
I
D
M
G
I
L
D
P
T
K
V
T
R
S
A
L
Q
Y
A
A
S
V
A
G
L
M
I
T
T
E
C
M
V
T
D
L
P
K
-----------------
83
PsiBlast_CBE
86.26
59%
-76
- C4 -
1MNF
3
CH60_ECOLI
D:
[2-525]
-
A
K
D
V
K
F
G
N
D
A
R
V
K
M
L
R
G
V
N
V
L
A
D
A
V
K
V
T
L
G
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