@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0462: (2016-04-22 )
MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMINF
Atome Classification :
(43 SA)
.........10........20........30...-.-.--------...40........50........60-.....--...70---.--..--.....80......----..90...----.----....100.......110.......---120..-...----------..130--------......------...140.......150.--.-.------.---....160.....-.-.-170.......180.......190-.......200...-....210...----.....220-..-.....230...---.-..---.240..----......250.-.-...----..-..260.......270.......280.......290.......300.......310..-.-.....320.......330.......340.......350.......360.......370.......380.......390.......400.......410..-.....420.......430.......440.......450-.---..-......460..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
H
Y
D
V
V
V
L
GAGPG
G
Y
V
A
A
I
R
A
A
QLGL
S
T
A
IVEP-K-Y--------WG
G
V
C
L
NVGCI
P
S
K
A
L
LRNA
E
L
V
H
I
-
F
TKD
A
--
K
AFGI---S--
G
E
--
V
T
F
D
YGIAYDRSR----KVAEGR
V
----
A
----
G
V
H
F
L
MKKNK
I
T
E
I
HGYGTFADA
N
---
T
L
L
V
D-LND----------GGT----------
E
S
V
T
FD------
N
A
I
I
ATGSS
T
R
LVP-GT--S-L------S---
A
N
V
V
T
Y
E
E
Q
I
L
S
-
R
-E-LPK
S
I
I
I
AGAG
A
I
G
M
E
F
G
Y
V
L
K
N-YGV
D
V
T
I
V
E
F
L
P
R
-ALPNE-D
A
D
V
----
S
K
E
I
E
K
Q
F
-
K
K-L
G
V
T
I
L
T
A
T
K
V
---
E
-
S
I---ADG-G
S
----
Q
V
T
V
T
VT--K-D-G
V
A
----
Q
E
-
L
K
A
E
K
V
L
Q
A
IGFAPNVEGYGLDKA
G
V
A
LTDRKAIGV
D
D
Y
M
RTNV
G
H
I
Y
A
IG
D
V
-
N
G
L
-
L
-
Q
L
A
H
V
A
EAQG
V
V
A
A
E
TIAGA
E
T
L
TLGDHRMLPRATFCQP
N
V
A
SFGL
T
E
Q
Q
ARNEG
Y
D
V
V
V
A
KFPFTANAKAHGVGD
P
S
G
F
V
K
L
VADAKHGELL
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
RWDL
T
A
S
E
L
A
R
NVHTHP
T
M
S
E
A
L
---
Q
---
E
C
-
F
H
G
L
V
G
H
MINF
2
PsiBlast_PDB
98.79
100%
-114
- C2 -
4M52
4
DLDH_MYCTU
A:
[3-466]
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-
Y
--------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
-
F
T
K
D
A
--
K
A
F
G
I
---
S
--
G
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
----
K
V
A
E
G
R
V
----
A
----
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---
T
L
L
V
D
-
L
N
D
----------
G
G
T
----------
E
S
V
T
F
D
------
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
--
S
-
L
------
S
---
A
N
V
V
T
Y
E
E
Q
I
L
S
-
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
-
A
L
P
N
E
-
D
A
D
V
----
S
K
E
I
E
K
Q
F
-
K
K
-
L
G
V
T
I
L
T
A
T
K
V
---
E
-
S
I
---
A
D
G
-
G
S
----
Q
V
T
V
T
V
T
--
K
-
D
-
G
V
A
----
Q
E
-
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
---
Q
---
E
C
-
F
H
G
L
V
G
H
M
I
N
F
23
PsiBlast_CBE
98.28
100%
-114
- C2 -
4M52
4
DLDH_MYCTU
B:
[3-466]
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-
Y
--------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
-
F
T
K
D
A
--
K
A
F
G
I
---
S
--
G
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
----
K
V
A
E
G
R
V
----
A
----
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---
T
L
L
V
D
-
L
N
D
----------
G
G
T
----------
E
S
V
T
F
D
------
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
--
S
-
L
------
S
---
A
N
V
V
T
Y
E
E
Q
I
L
S
-
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
-
A
L
P
N
E
-
D
A
D
V
----
S
K
E
I
E
K
Q
F
-
K
K
-
L
G
V
T
I
L
T
A
T
K
V
---
E
-
S
I
---
A
D
G
-
G
S
----
Q
V
T
V
T
V
T
--
K
-
D
-
G
V
A
----
Q
E
-
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
---
Q
---
E
C
-
F
H
G
L
V
G
H
M
I
N
F
109
HHSearch
98.13
100%
-115
- C2 -
2A8X
3
DLDH_MYCTU
A:
[1-462]
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-
Y
--------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
-
F
T
K
D
A
--
K
A
F
G
I
---
S
--
G
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
----
K
V
A
E
G
R
V
----
A
----
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---
T
L
L
V
D
-
L
N
D
----------
G
G
T
----------
E
S
V
T
F
D
------
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
--
S
-
L
------
S
---
A
N
V
V
T
Y
E
E
Q
I
L
S
-
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
-
A
L
P
N
E
-
D
A
D
V
----
S
K
E
I
E
K
Q
F
-
K
K
-
L
G
V
T
I
L
T
A
T
K
V
---
E
-
S
I
---
A
D
G
-
G
S
----
Q
V
T
V
T
V
T
--
K
-
D
-
G
V
A
----
Q
E
-
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
---
Q
---
E
C
-
F
H
G
L
V
G
H
M
I
--
21
PsiBlast_CBE
97.82
100%
-116
- C2 -
4M52
5
DLDH_MYCTU
D:
[3-466]
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-
Y
--------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
-
F
T
K
D
A
--
K
A
F
G
I
---
S
--
G
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
----
K
V
A
E
G
R
V
----
A
----
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---
T
L
L
V
D
-
L
N
D
----------
G
G
T
----------
E
S
V
T
F
D
------
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
--
S
-
L
------
S
---
A
N
V
V
T
Y
E
E
Q
I
L
S
-
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
-
A
L
P
N
E
-
D
A
D
V
----
S
K
E
I
E
K
Q
F
-
K
K
-
L
G
V
T
I
L
T
A
T
K
V
---
E
-
S
I
---
A
D
G
-
G
S
----
Q
V
T
V
T
V
T
--
K
-
D
-
G
V
A
----
Q
E
-
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
---
Q
---
E
C
-
F
H
G
L
V
G
H
M
I
N
F
3
PsiBlast_PDB
97.80
98%
-115
- C2 -
2A8X
3
DLDH_MYCTU
A:
[2-464]
-
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-
Y
--------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
-
F
T
K
D
A
--
K
A
F
G
I
---
S
--
G
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
----
K
V
A
E
G
R
V
----
A
----
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---
T
L
L
V
D
-
L
N
D
----------
G
G
T
----------
E
S
V
T
F
D
------
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
--
S
-
L
------
S
---
A
N
V
V
T
Y
E
E
Q
I
L
S
-
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
-
A
L
P
N
E
-
D
A
D
V
----
S
K
E
I
E
K
Q
F
-
K
K
-
L
G
V
T
I
L
T
A
T
K
V
---
E
-
S
I
---
A
D
G
-
G
S
----
Q
V
T
V
T
V
T
--
K
-
D
-
G
V
A
----
Q
E
-
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
---
Q
---
E
C
-
F
H
G
L
V
G
H
M
I
N
F
24
PsiBlast_CBE
97.58
100%
-113
- C2 -
3II4
3
DLDH_MYCTU
B:
[3-466]
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-
Y
--------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
-
F
T
K
D
A
--
K
A
F
G
I
---
S
--
G
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
----
K
V
A
E
G
R
V
----
A
----
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---
T
L
L
V
D
-
L
N
D
----------
G
G
T
----------
E
S
V
T
F
D
------
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
--
S
-
L
------
S
---
A
N
V
V
T
Y
E
E
Q
I
L
S
-
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
-
A
L
P
N
E
-
D
A
D
V
----
S
K
E
I
E
K
Q
F
-
K
K
-
L
G
V
T
I
L
T
A
T
K
V
---
E
-
S
I
---
A
D
G
-
G
S
----
Q
V
T
V
T
V
T
--
K
-
D
-
G
V
A
----
Q
E
-
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
---
Q
---
E
C
-
F
H
G
L
V
G
H
M
I
N
F
1
PsiBlast_PDB
97.47
100%
-113
- C2 -
3II4
3
DLDH_MYCTU
A:
[4-466]
-
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-
Y
--------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
-
F
T
K
D
A
--
K
A
F
G
I
---
S
--
G
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
----
K
V
A
E
G
R
V
----
A
----
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---
T
L
L
V
D
-
L
N
D
----------
G
G
T
----------
E
S
V
T
F
D
------
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
--
S
-
L
------
S
---
A
N
V
V
T
Y
E
E
Q
I
L
S
-
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
-
A
L
P
N
E
-
D
A
D
V
----
S
K
E
I
E
K
Q
F
-
K
K
-
L
G
V
T
I
L
T
A
T
K
V
---
E
-
S
I
---
A
D
G
-
G
S
----
Q
V
T
V
T
V
T
--
K
-
D
-
G
V
A
----
Q
E
-
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
---
Q
---
E
C
-
F
H
G
L
V
G
H
M
I
N
F
22
PsiBlast_CBE
96.97
100%
-115
- C2 -
4M52
4
DLDH_MYCTU
C:
[3-466]
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-
Y
--------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
-
F
T
K
D
A
--
K
A
F
G
I
---
S
--
G
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
----
K
V
A
E
G
R
V
----
A
----
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---
T
L
L
V
D
-
L
N
D
----------
G
G
T
----------
E
S
V
T
F
D
------
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
--
S
-
L
------
S
---
A
N
V
V
T
Y
E
E
Q
I
L
S
-
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
-
A
L
P
N
E
-
D
A
D
V
----
S
K
E
I
E
K
Q
F
-
K
K
-
L
G
V
T
I
L
T
A
T
K
V
---
E
-
S
I
---
A
D
G
-
G
S
----
Q
V
T
V
T
V
T
--
K
-
D
-
G
V
A
----
Q
E
-
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
---
Q
---
E
C
-
F
H
G
L
V
G
H
M
I
N
F
121
HHSearch
72.52
39%
-100
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[2-454]
-
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-
G
-
N
--------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
E
Q
-
A
K
H
-
S
--
E
E
M
G
I
---
K
A
-
E
N
--
V
T
I
D
F
A
K
V
Q
E
W
K
A
----
S
V
V
K
K
L
T
----
G
----
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
---
T
V
R
V
V
-
N
G
D
-----------
S
A
----------
Q
T
Y
T
F
K
------
N
A
I
I
A
T
G
S
R
P
I
E
L
P
-
N
F
--
K
-
F
------
S
---
N
R
I
L
D
S
T
G
A
L
N
L
-
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
-
I
L
S
G
F
-
E
K
Q
M
----
A
A
I
I
K
K
R
L
-
K
K
-
K
G
V
E
V
V
T
N
A
L
A
---
K
-
G
A
---
E
E
R
-
E
D
----
G
V
T
V
T
Y
E
--
A
-
N
-
G
E
T
----
K
T
-
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
-
V
P
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
--
A
V
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
-
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
---
M
---
E
A
-
A
E
V
A
-------
4
PsiBlast_PDB
71.17
39%
-96
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[5-450]
----
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-
G
-
N
--------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
R
Y
E
-
Q
A
K
H
S
--
E
E
M
G
I
---
K
--
A
E
N-
V
T
I
D
F
A
K
V
Q
E
W
K
A
----
S
V
V
K
K
L
T
----
G
----
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
---
T
V
R
V
--
V
N
G
----------
D
S
A
----------
Q
T
Y
T
F
K
------
N
A
I
I
A
T
G
S
R
P
I
E
L
P
-
N
F
--
K
-
F
------
S
---
N
R
I
L
D
S
T
G
A
L
N
L
-
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
-
I
L
S
G
F
-
E
K
Q
M
----
A
A
I
I
K
K
R
L
-
K
K
-
K
G
V
E
V
V
T
N
A
L
A
---
K
-
G
A
---
E
E
R
-
E
D
----
G
V
T
V
T
Y
E
--
A
-
N
-
G
E
T
----
K
T
-
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
-
V
P
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
A
V
--
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
-
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
---
M
---
E
A
------------
10
PsiBlast_PDB
71.10
37%
-98
- C2 -
3LAD
2
DLDH_AZOVI
A:
[4-470]
---
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
--
K
-
Y
KGKEGKTA
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
H
E
-
A
H
E
S
F
--
K
L
H
G
I
---
S
T
-
G
E
--
V
A
I
D
V
P
T
M
I
A
R
K
D
----
Q
I
V
R
N
L
T
----
G
----
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
K
---
K
V
E
V
T
-
A
A
D
----------
G
S
S
----------
Q
V
L
D
T
E
------
N
V
I
L
A
S
G
S
K
P
V
E
I
P
-
P
A
--
P
-
V
------
D
---
Q
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
M
D
K
-
F
L
P
A
V
-
D
E
Q
V
----
A
K
E
A
Q
K
I
L
-
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
---
T
-
G
T
---
E
V
K
-
N
K
----
Q
V
T
V
K
F
V
--
D
-
A
-
E
G
E
----
K
S
-
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
-
V
R
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
-
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
---
H
---
E
A
-
A
L
A
V
S
G
H
A
I
H
-
104
HHSearch
71.08
38%
-98
- C2 -
2QAE
2
DLDH_TRYCR
A:
[1-464]
-
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
R
G
-
A
--------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
-
A
H
A
N
F
--
A
R
Y
G
L
---
M
GG
E
G
--
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
----
R
A
V
K
G
L
T
----
G
----
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
---
S
I
R
V
N
-
G
L
D
----------
G
K
Q
----------
E
M
L
E
T
K
------
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
P-
F
-
D
------
E
---
K
V
V
L
S
S
T
G
A
L
A
L
-
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
-
C
A
P
T
L
-
D
E
D
V
----
T
N
A
L
V
G
A
L
-
A
K
N
E
K
M
K
F
M
T
S
T
K
V
---
V
-
G
G
---
T
N
N
-
G
D
----
S
V
S
L
E
V
E
------
G
K
R
----
E
T
-
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
-
V
D
K
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
--
H
V
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
-
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
---
K
---
E
A
-
C
M
A
L
F
A
K
----
7
PsiBlast_PDB
70.69
37%
-96
- C2 -
1LPF
2
DLDH_PSEFL
A:
[4-471]
---
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
--
K
-
Y
IGKEGKVA
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
-
A
K
E
A
F
--
K
V
H
G
I
---
E
--
A
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
----
N
I
V
K
N
L
T
----
G
----
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
---
Q
V
E
V
T
-
G
L
D
----------
G
K
T
----------
Q
V
L
E
A
E
------
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
--
P
-
L
------
S
---
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
K
-
F
L
P
A
A
-
D
E
Q
I
----
A
K
E
A
L
K
V
L
-
T
K
-
Q
G
L
N
I
R
L
G
A
R
V
---
T
-
A
S
---
E
V
K
-
K
K
----
Q
V
T
V
T
F
T
--
D
-
A
-
N
G
E
----
Q
K
-
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
-
V
R
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
-
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
---
H
---
E
A
-
A
L
A
V
N
G
H
A
I
H
I
28
PsiBlast_CBE
70.54
37%
-96
- C2 -
1LPF
2
DLDH_PSEFL
B:
[4-471]
---
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
--
K
-
Y
IGKEGKVA
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
-
A
K
E
A
F
--
K
V
H
G
I
---
E
--
A
K
G-
V
T
I
D
V
P
A
M
V
A
R
K
A
----
N
I
V
K
N
L
T
----
G
----
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
---
Q
V
E
V
T
-
G
L
D
----------
G
K
T
----------
Q
V
L
E
A
E
------
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
--
P
-
L
------
S
---
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
K
-
F
L
P
A
A
-
D
E
Q
I
----
A
K
E
A
L
K
V
L
-
T
K
-
Q
G
L
N
I
R
L
G
A
R
V
---
T
-
A
S
---
E
V
K
-
K
K
----
Q
V
T
V
T
F
T
--
D
-
A
-
N
G
E
----
Q
K
-
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
-
V
R
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
-
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
---
H
---
E
A
-
A
L
A
V
N
G
H
A
I
H
I
71
PsiBlast_CBE
70.53
37%
-91
- C2 -
2EQ9
2
?
H:
[4-463]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-
E
--------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
--
H
L
K
V
A
--
E
G
F
G
L
---
K
--
A
K
--
P
E
L
D
L
K
K
L
G
G
W
R
D
----
Q
V
V
K
K
L
T
----
G
----
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
---
E
V
E
V
----------------
G
G
----------
E
R
Y
G
A
K
------
S
L
I
L
A
T
G
S
E
P
L
E
L
K
-
G
F
--
P
-
F
------
G
---
E
D
V
W
D
S
T
R
A
L
K
V
-
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
-
I
L
P
Q
G
-
D
P
E
T
----
A
A
L
L
R
R
A
L
-
E
K
-
E
G
I
R
V
R
T
K
T
K
A
VGY
E
-
K
K
---
K
D
G
--
L
----
H
V
R
L
E
P
A
--
E
-
G
-
G
E
G
----
E
E
-
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
-
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
--
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
---
M
EAA
E
A
-
F
H
K
Q
A
I
H
I
L
N
-
72
PsiBlast_CBE
70.26
37%
-90
- C2 -
2EQ9
2
?
G:
[4-463]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-
E
--------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
--
H
L
K
V
A
--
E
G
F
G
L
---
K
--
A
K
--
P
E
L
D
L
K
K
L
G
G
W
R
D
----
Q
V
V
K
K
L
T
----
G
----
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
---
E
V
E
V
----------------
G
G
----------
E
R
Y
G
A
K
------
S
L
I
L
A
T
G
S
E
P
L
E
L
K
-
G
F
--
P
-
F
------
G
---
E
D
V
W
D
S
T
R
A
L
K
V
-
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
-
I
L
P
Q
G
-
D
P
E
T
----
A
A
L
L
R
R
A
L
-
E
K
-
E
G
I
R
V
R
T
K
T
K
A
VGY
E
-
K
K
---
K
D
G
--
L
----
H
V
R
L
E
P
A
--
E
-
G
-
G
E
G
----
E
E
-
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
-
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
--
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
---
M
EAA
E
A
-
F
H
K
Q
A
I
H
I
L
N
-
55
PsiBlast_CBE
69.98
35%
-95
- C2 -
1ZMD
4
DLDH_HUMAN
B:
[8-474]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
N
E
-
T
--------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
Y
Y
H
M
A
H
G
T
D
F
--
A
S
R
G
I
---
E
M-
S
E
--
V
R
L
N
L
D
K
M
M
E
Q
K
S
----
T
A
V
K
A
L
T
----
G
----
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
---
Q
V
T
A
T
-
K
A
D
----------
G
G
T
----------
Q
V
I
D
T
K
------
N
I
L
I
A
T
G
S
E
V
T
P
F
P
-
G
I
--
T
-
I
------
D
---
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
-
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
-
D
M
E
I
----
S
K
N
F
Q
R
I
L
-
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
---
T
-
G
A
T
K
K
S
D
G
-
K
I
----
D
V
S
I
E
A
A
--
S
-
G
-
G
K
A
----
E
V
-
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
-
V
A
G
-
P
-
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
-
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
---
R
---
E
A
N
L
A
A
S
F
G
K
S
I
N
F
80
PsiBlast_CBE
69.85
37%
-91
- C2 -
2EQ6
2
?
B:
[4-463]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-
E
--------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
--
H
L
K
V
A
--
E
G
F
G
L
---
K
--
A
K
--
P
E
L
D
L
K
K
L
G
G
W
R
D
----
Q
V
V
K
K
L
T
----
G
----
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
---
E
V
E
V
----------------
G
G
----------
E
R
Y
G
A
K
------
S
L
I
L
A
T
G
S
E
P
L
E
L
K
-
G
F
--
P
-
F
------
G
---
E
D
V
W
D
S
T
R
A
L
K
V
-
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
-
I
L
P
Q
G
-
D
P
E
T
----
A
A
L
L
R
R
A
L
-
E
K
-
E
G
I
R
V
R
T
K
T
K
A
VGY
E
-
K
K
---
K
D
G
--
L
----
H
V
R
L
E
P
A
--
E
-
G
-
G
E
G
----
E
E
-
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
-
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
--
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
---
M
EAA
E
A
-
F
H
K
Q
A
I
H
I
L
N
-
70
PsiBlast_CBE
69.60
37%
-90
- C2 -
2EQ9
2
?
J:
[4-463]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-
E
--------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
--
H
L
K
V
A
--
E
G
F
G
L
---
K
--
A
K
--
P
E
L
D
L
K
K
L
G
G
W
R
D
----
Q
V
V
K
K
L
T
----
G
----
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
---
E
V
E
V
----------------
G
G
----------
E
R
Y
G
A
K
------
S
L
I
L
A
T
G
S
E
P
L
E
L
K
-
G
F
--
P
-
F
------
G
---
E
D
V
W
D
S
T
R
A
L
K
V
-
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
-
I
L
P
Q
G
-
D
P
E
T
----
A
A
L
L
R
R
A
L
-
E
K
-
E
G
I
R
V
R
T
K
T
K
A
VGY
E
-
K
K
---
K
D
G
--
L
----
H
V
R
L
E
P
A
--
E
-
G
-
G
E
G
----
E
E
-
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
-
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
--
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
---
M
EAA
E
A
-
F
H
K
Q
A
I
H
I
L
N
-
20
PsiBlast_PDB
69.59
37%
-91
- C2 -
2EQ8
2
?
A:
[4-463]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-
E
--------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
--
H
L
K
V
A
--
E
G
F
G
L
---
K
--
A
K
--
P
E
L
D
L
K
K
L
G
G
W
R
D
----
Q
V
V
K
K
L
T
----
G
----
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
---
E
V
E
V
----------------
G
G
----------
E
R
Y
G
A
K
------
S
L
I
L
A
T
G
S
E
P
L
E
L
K
-
G
F
--
P
-
F
------
G
---
E
D
V
W
D
S
T
R
A
L
K
V
-
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
-
I
L
P
Q
G
-
D
P
E
T
----
A
A
L
L
R
R
A
L
-
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
-
K
K
---
K
D
G
--
L
----
H
V
R
L
E
P
A
--
E
-
G
-
G
E
G
----
E
E
-
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
-
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
--
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
---
M
E
A
A
E
A
-
F
H
K
Q
A
I
H
I
L
N
-
19
PsiBlast_PDB
69.14
37%
-88
- C2 -
2EQ6
2
?
A:
[4-463]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-
E
--------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
--
H
L
K
V
A
--
E
G
F
G
L
---
K
--
A
K
--
P
E
L
D
L
K
K
L
G
G
W
R
D
----
Q
V
V
K
K
L
T
----
G
----
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
---
E
V
E
V
----------------
G
G
----------
E
R
Y
G
A
K
------
S
L
I
L
A
T
G
S
E
P
L
E
L
K
-
G
F
--
P
-
F
------
G
---
E
D
V
W
D
S
T
R
A
L
K
V
-
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
-
I
L
P
Q
G
-
D
P
E
T
----
A
A
L
L
R
R
A
L
-
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
-
K
K
---
K
D
G
--
L
----
H
V
R
L
E
P
A
--
E
-
G
-
G
E
G
----
E
E
-
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
-
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
--
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
---
M
E
A
A
E
A
-
F
H
K
Q
A
I
H
I
L
N
-
115
HHSearch
68.96
37%
-92
- C2 -
2EQ6
2
?
A:
[4-458]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-
E
--------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
-
L
K
V
-
A
--
E
G
F
G
L
---
K
--
A
K
--
P
E
L
D
L
K
K
L
G
G
W
R
D
----
Q
V
V
K
K
L
T
----
G
----
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
---
E
V
E
V
----------------
G
G
----------
E
R
Y
G
A
K
------
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--------
G
---
E
D
V
W
D
S
T
R
A
L
K
V
-
E
E
G
-
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
-
I
L
P
Q
G
-
D
P
E
T
----
A
A
L
L
R
R
A
L
-
E
K
-
E
G
I
R
V
R
T
K
T
K
A
---
V
-
G
Y
---
E
K
K
-
K
D
----
G
L
H
V
R
L
E
PA
E
-
G
-
G
E
G
----
E
E
-
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
-
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
--
A
F
D
Y
-
Q
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
---
M
---
E
A
-
A
E
A
F
H
K
Q
A
---
25
PsiBlast_CBE
68.85
39%
-97
- C2 -
1EBD
2
DLDH1_GEOSE
B:
[5-450]
----
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-
G
-
N
--------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
R
Y
E
-
Q
A
K
H
S
--
E
E
M
G
I
---
K
--
A
E
N-
V
T
I
D
F
A
K
V
Q
E
W
K
A
----
S
V
V
K
K
L
T
----
G
----
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
---
T
V
R
V
--
V
N
G
----------
D
S
A
----------
Q
T
Y
T
F
K
------
N
A
I
I
A
T
G
S
R
P
I
E
L
P
-
N
F
--
K
-
F
------
S
---
N
R
I
L
D
S
T
G
A
L
N
L
-
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
-
I
L
S
G
F
-
E
K
Q
M
----
A
A
I
I
K
K
R
L
-
K
K
-
K
G
V
E
V
V
T
N
A
L
A
---
K
-
G
A
---
E
E
R
-
E
D
----
G
V
T
V
T
Y
E
--
A
-
N
-
G
E
T
----
K
T
-
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
-
V
P
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
A
V
--
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
-
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
---
M
---
E
A
------------
93
Fugue
68.35
37%
-97
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[1-455]
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-
G
-
N
--------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
E
Q
-
A
K
H
-
S
--
E
E
M
G
I
---
K
A
E
-
N
--
V
T
I
D
F
A
K
V
Q
E
W
K
A
----
S
V
V
K
K
L
T
----
G
----
G
V
E
G
L
L
K
G
N
K
-
V
E
I
V
K
-
G
E
A
Y
F
V
-DAN
T
V
R
V
V
N
--
G
----------
D
S
A
----------
Q
T
Y
T
F
K
------
N
A
I
I
A
T
G
S
R
P
I
E
L
P
-
N
F
--
K
-
F
SNRILD----
S
T
G
A
L
N
L
G
-------
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
-
G
T
K
V
T
I
L
E
G
A
G
E
-
I
L
S
G
-F
E
K
Q
M
----
A
A
I
I
K
K
R
L
-
K
K
-
K
G
V
E
V
V
T
N
A
L
A
---
K
-
G
A
---
E
E
R
-
E
-----
D
G
V
T
V
T
Y
--
E
-
A
-
N
--G
E
T
K
T
I
-
D
-
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
-
V
P
G
--P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
-
H
P
S
A
V
D
Y
V
A
I
P
A
V
V
F
S
D
-
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
-P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
P
T
--
L
---
G
---
E
I
-
A
M
E
A
A
E
V
A
L
--
103
HHSearch
68.12
34%
-98
- C2 -
1LVL
2
DLDH1_PSEPU
A:
[3-457]
T
I
Q
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-
Q
-
A
--------
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
V
A
E
Q
F
H
Q
-
A
S
R
F
T
E
P
S
P
L
G
I
---
S
V
-
A
S
--
P
R
L
D
I
G
Q
S
V
A
W
K
D
----
G
I
V
D
R
L
T
----
T
----
G
V
A
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
K
V
L
D
G
K
---
Q
V
E
V
D
----------------
G
----------
Q
R
I
Q
C
E
------
H
L
L
L
A
T
G
S
S
S
V
E
L
P
-
M
L
--
P
-
L
------
G
---
G
P
V
I
S
S
T
E
A
L
A
P
-
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
-
L
G
A
Q
V
S
V
V
E
A
R
E
R
-
I
L
P
T
Y
-
D
S
E
L
----
T
A
P
V
A
E
S
L
-
K
K
-
L
G
I
A
L
H
L
G
H
S
V
---
E
-
G
Y
---
E
N
G
---------
C
L
L
A
N
--
D
-
G
K
G
G
Q
----
L
R
-
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
-
G
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
-
A
G
E
-
P
-
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
A
G
K
A
R
--
R
F
E
P
A
A
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
-
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
---
Q
---
E
A
-
A
L
R
A
L
G
H
A
L
H
-
122
HHSearch
68.07
38%
-101
- C2 -
2YQU
4
?
A:
[1-450]
--
M
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E
K
-
A
--------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
-
A
K
K
G
----
L
L
G
A
---
K
V-
K
G
--
V
E
L
D
L
P
A
L
M
A
H
K
D
----
K
V
V
Q
A
N
T
----
Q
----
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
---
K
V
L
V
E
-
E
-------------
T
G
----------
E
E
L
E
A
R
------
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q-
V
-
D
------
Y
---
E
R
V
V
T
S
T
E
A
L
S
F
-
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
-
I
L
P
T
M
-
D
L
E
V
----
S
R
A
A
E
R
V
F
-
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
---
T
-
A
V
---
V
P
E
-
A
K
----
G
A
R
V
E
L
E
-------
G
G
----
E
V
-
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
-
V
R
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
--
H
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
-
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
---
K
---
E
A
-
A
L
A
A
W
E
-----
26
PsiBlast_CBE
67.27
38%
-98
- C2 -
2YQU
6
?
B:
[2-444]
---
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E
K
-
A
--------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
-
A
K
K
G
L
--
L
G
A
K
V
---
K
--
G
---
V
E
L
D
L
P
A
L
M
A
H
K
D
----
K
V
V
Q
A
N
T
----
Q
----
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
---
K
V
L
V
E
-
E
T
G
-----------------------
E
E
L
E
A
R
------
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
--
Q
-
V
------
D
Y--
E
R
V
V
T
S
T
E
A
L
S
F
-
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
-
I
L
P
T
M
-
D
L
E
V
----
S
R
A
A
E
R
V
F
-
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
---
T
-
A
V
---
V
P
E
-
A
K
----
G
A
R
V
E
L
E
--
G
-
G
-
E
V
--------
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
-
V
R
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
--
R
G
F
G
H
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
-
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
---
K
---
E
A
------------
106
HHSearch
67.07
37%
-97
* C2 *
3URH
3
?
A:
[26-486]
---
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
R
S
-
T
--------
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
Q
-
A
Q
H
G
L
--
E
A
L
G
V
---
E
V
-
A
N
--
P
K
L
N
L
Q
K
M
M
A
H
K
D
----
A
T
V
K
S
N
V
----
D
----
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
---
K
V
S
V
T
-
N
E
K
----------
G
E
E
----------
Q
V
L
E
A
K
------
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
A
F
-
D
------
E
---
K
T
I
V
S
S
T
G
A
L
A
L
-
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
K
V
T
V
V
E
F
L
D
T
-
I
L
G
G
M
-
D
G
E
V
----
A
K
Q
L
Q
R
M
L
-
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
---
T
-
G
A
---
V
K
S
-
G
D
----
G
A
K
V
T
F
E
PV
K
-
G
-
G
E
A
----
T
T
-
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
-
V
R
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
G
--
H
V
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
-
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
---
K
---
E
A
-
A
L
S
T
F
F
-----
5
PsiBlast_PDB
66.94
38%
-98
- C2 -
2EQ7
3
?
A:
[2-444]
---
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E
K
-
A
--------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
-
A
K
K
G
L
--
L
G
A
K
V
---
K
--
G
---
V
E
L
D
L
P
A
L
M
A
H
K
D
----
K
V
V
Q
A
N
T
----
Q
----
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
---
K
V
L
V
E
-
E
T
G
-----------------------
E
E
L
E
A
R
------
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
--
Q
-
V
------
D
Y--
E
R
V
V
T
S
T
E
A
L
S
F
-
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
-
I
L
P
T
M
-
D
L
E
V
----
S
R
A
A
E
R
V
F
-
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
---
T
-
A
V
---
V
P
E
-
A
K
----
G
A
R
V
E
L
E
--
G
-
G
-
E
V
--------
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
-
V
R
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
--
R
G
F
G
H
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
-
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
---
K
---
E
A
------------
27
PsiBlast_CBE
66.56
38%
-98
- C2 -
2EQ7
3
?
B:
[2-444]
---
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E
K
-
A
--------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
-
A
K
K
G
L
--
L
G
A
K
V
---
K
--
G
---
V
E
L
D
L
P
A
L
M
A
H
K
D
----
K
V
V
Q
A
N
T
----
Q
----
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
---
K
V
L
V
E
-
E
T
G
-----------------------
E
E
L
E
A
R
------
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
--
Q
-
V
------
D
Y--
E
R
V
V
T
S
T
E
A
L
S
F
-
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
-
I
L
P
T
M
-
D
L
E
V
----
S
R
A
A
E
R
V
F
-
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
---
T
-
A
V
---
V
P
E
-
A
K
----
G
A
R
V
E
L
E
--
G
-
G
-
E
V
--------
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
-
V
R
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
--
R
G
F
G
H
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
-
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
---
K
---
E
A
------------
39
PsiBlast_CBE
66.41
37%
-91
- C2 -
3LAD
2
DLDH_AZOVI
B:
[4-470]
---
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
--
K
-
Y
KGKEGKTA
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
H
E
-
A
H
E
S
F
--
K
L
H
G
I
---
S
T-
G
E
--
V
A
I
D
V
P
T
M
I
A
R
K
D
----
Q
I
V
R
N
L
T
----
G
----
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
K
---
K
V
E
V
T
-
A
A
D
----------
G
S
S
----------
Q
V
L
D
T
E
------
N
V
I
L
A
S
G
S
K
P
V
E
I
P
-
P
A
--
P
-
V
------
D
---
Q
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
M
D
K
-
F
L
P
A
V
-
D
E
Q
V
----
A
K
E
A
Q
K
I
L
-
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
---
T
-
G
T
---
E
V
K
-
N
K
----
Q
V
T
V
K
F
V
--
D
-
A
-
E
G
E
----
K
S
-
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
-
V
R
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
-
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
---
H
---
E
A
-
A
L
A
V
S
G
H
A
I
H
-
88
PsiBlast_CBE
66.17
38%
-98
- C2 -
4JDR
9
DLDH_ECOLI
A:
[9-468]
-----
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
--
R
-
Y
NT------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
-----
E
E
A
--
K
A
L
A
E
---
H
--
G
I
--
V
F
G
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
----
G
----
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
N
---
T
L
E
V
E
-
G
E
N
----------
G
K
T
-----------
V
I
N
F
D
------
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
-
F
I
--
P
H
E
------
D
---
P
R
I
W
D
S
T
D
A
L
E
L
-
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
-
V
I
P
A
A
-
D
K
D
I
V
K
V
F
T
K
R
I
S
K
K
F
-
N
L
-
M
L
E
T
K
V
T
A
--
V
---
E
-
A
K
---
E
D
G
--------
I
Y
V
T
M
E
G
-
K
-
K
-
A
P
A
----
E
P
-
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
-
V
G
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
H
Y
F
--
D
P
K
V
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
-
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
---
E
V
-
F
E
G
S
I
T
D
L
P
N
-
110
HHSearch
65.88
37%
-89
- C2 -
1OJT
1
?
A:
[4-473]
D
A
E
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y
K
-
T
--------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
V
I
D
E
-
V
R
H
-
L
--
A
A
N
G
I
---
K
Y-
P
E
--
P
E
L
D
I
D
M
L
R
A
Y
K
D
----
G
V
V
S
R
L
T
----
G
----
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
H
---
H
L
E
V
S
-
L
T
A
G
DAYE
Q
A
A
P
T
G
E
K
----------
K
I
V
A
F
K
------
N
C
I
I
A
A
G
S
R
V
T
K
L
P
-
F
I
--
P
-
E
------
D
---
P
R
I
I
D
S
S
G
A
L
A
L
-
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
-
L
G
S
R
L
D
V
V
E
M
M
D
G
-
L
M
Q
G
A
-
D
R
D
L
----
V
K
V
W
Q
K
Q
N
-
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
---
V
-
A
V
---
E
P
K
-
E
D
----
G
V
Y
V
T
F
E
--
G
A
N
-
A
P
K
----
E
P
-
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
-
V
G
Q
-
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
A
--
Y
F
D
A
R
V
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
-
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
T
L
G
E
S
I
---
G
---
M
A
-
A
E
V
A
L
G
T
----
87
PsiBlast_CBE
65.36
38%
-98
- C2 -
4JDR
5
DLDH_ECOLI
B:
[9-468]
-----
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
--
R
-
Y
NT------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
-----
E
E
A
--
K
A
L
A
E
---
H
--
G
I
--
V
F
G
E
P
K
T
D
I
D
K
I
R
TWKE
K
V
I
N
Q
L
T
----
G
----
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
N
---
T
L
E
V
E
-
G
E
N
----------
G
K
T
-----------
V
I
N
F
D
------
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
-
F
I
--
P
H
E
------
D
---
P
R
I
W
D
S
T
D
A
L
E
L
-
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
-
V
I
P
A
A
-
D
K
D
I
VKVF
T
K
R
I
S
K
K
F
-
N
L
-
M
L
E
T
K
V
T
A
--
V
---
E
-
A
K
---
E
D
G
--------
I
Y
V
T
M
E
G-
K
-
K
-
A
P
A
----
E
P
-
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
-
V
G
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
H
Y
F
--
D
P
K
V
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
-
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
GLA
A
---
E
V
-
F
E
G
S
I
T
D
L
P
N
-
15
PsiBlast_PDB
65.28
37%
-91
- C2 -
2QAE
2
DLDH_TRYCR
A:
[17-468]
-----------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
-
R
G
A
--------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
-
A
H
A
N
F
--
A
R
Y
G
L
---
M
--
G
G
EG
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
----
R
A
V
K
G
L
T
----
G
----
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
---
S
I
R
V
N
-
G
L
D
----------
G
K
Q
----------
E
M
L
E
T
K
------
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
--
P
-
F
------
D
---
E
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
-
C
A
P
T
L
-
D
E
D
V
----
T
N
A
L
V
G
A
L
A
K
N
-
E
K
M
K
F
M
T
S
T
K
V
---
V
-
G
G
---
T
N
N
-
G
D
----
S
V
S
L
E
V
E
G-
K
-----
R
----
E
T
-
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
H
V
--
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
-
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
---
K
---
E
A
-
C
M
A
L
F
A
K
T
I
N
F
68
PsiBlast_CBE
65.14
37%
-89
- C2 -
1JEH
2
DLDH_YEAST
B:
[6-466]
---
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-
R
G
K
--------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
-
M
H
T
E
A
--
Q
K
R
G
I
-------
D
--
V
N
G
D
I
K
I
N
V
A
N
F
Q
----
K
A
K
D
D
A
V
KQLT
G
----
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
---
K
I
R
V
T
-
P
V
D
----------
G
L
E
----------
G
T
V
K
E
D
HILDVK
N
I
I
V
A
T
G
S
E
V
T
P
F
P
-
G
I
--
E
-
I
------
D
---
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
-
I
G
A
S
M
-
D
G
E
V
----
A
K
A
T
Q
K
F
L
-
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
---
I
-
S
A
---
K
R
N
-
D
D
KNVV
E
I
V
V
E
D
T
--
K
-
T
-
N
K
Q
----
E
N
-
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
-
T
F
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
G
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
-
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
---
K
---
E
-------------
66
PsiBlast_CBE
64.68
37%
-90
- C2 -
2QAE
2
DLDH_TRYCR
B:
[17-468]
-----------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
-
R
G
A
--------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
-
A
H
A
N
F
--
A
R
Y
G
L
---
M
--
G
G
EG
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
----
R
A
V
K
G
L
T
----
G
----
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
---
S
I
R
V
N
-
G
L
D
----------
G
K
Q
----------
E
M
L
E
T
K
------
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
--
P
-
F
------
D
---
E
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
-
C
A
P
T
L
-
D
E
D
V
----
T
N
A
L
V
G
A
L
A
K
N
-
E
K
M
K
F
M
T
S
T
K
V
---
V
-
G
G
---
T
N
N
-
G
D
----
S
V
S
L
E
V
E
G-
K
-----
R
----
E
T
-
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
H
V
--
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
-
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
---
K
---
E
A
-
C
M
A
L
F
A
K
T
I
N
F
16
PsiBlast_PDB
64.49
37%
-90
- C2 -
1JEH
2
DLDH_YEAST
A:
[6-466]
---
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-
R
G
K
--------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
-
M
H
T
E
A
--
Q
K
R
G
I
-------
D
--
V
N
G
D
I
K
I
N
V
A
N
F
Q
----
K
A
K
D
D
A
V
K
Q
L
T
G
----
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
---
K
I
R
V
T
-
P
V
D
----------
G
L
E
----------
G
T
V
K
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
-
G
I
--
E
-
I
------
D
---
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
-
I
G
A
S
M
-
D
G
E
V
----
A
K
A
T
Q
K
F
L
-
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
---
I
-
S
A
---
K
R
N
-
D
D
KNVV
E
I
V
V
E
D
T
--
K
-
T
-
N
K
Q
----
E
N
-
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
-
T
F
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
G
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
-
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
---
K
---
E
-------------
67
PsiBlast_CBE
64.40
37%
-89
- C2 -
1V59
3
DLDH_YEAST
B:
[6-466]
---
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-
R
G
K
--------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
-
M
H
T
E
A
--
Q
K
R
G
I
-------
D
--
V
N
G
D
I
K
I
N
V
A
N
F
Q
----
K
A
K
D
D
A
V
KQLT
G
----
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
---
K
I
R
V
T
-
P
V
D
----------
G
L
E
----------
G
T
V
K
E
D
HILDVK
N
I
I
V
A
T
G
S
E
V
T
P
F
P
-
G
I
--
E
-
I
------
D
---
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
-
I
G
A
S
M
-
D
G
E
V
----
A
K
A
T
Q
K
F
L
-
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
---
I
-
S
A
---
K
R
N
-
D
D
KNVV
E
I
V
V
E
D
T
--
K
-
T
-
N
K
Q
----
E
N
-
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
-
T
F
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
G
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
-
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
---
K
---
E
-------------
18
PsiBlast_PDB
64.27
37%
-91
- C2 -
3URH
3
?
A:
[26-480]
---
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
-
R
-
S
T-------
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
Q
-
A
Q
H
G
L
--
E
A
L
G
V
E
V
A
N
--
P
K
--
L
N
L
Q
K
M
M
A
H
K
D
A
------
T
V
K
S
N
V
----
D
----
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
---
K
V
S
V
T
-
N
E
K
----------
G
E
E
----------
Q
V
L
E
A
K
------
N
V
V
I
A
T
G
S
D
V
A
G
I
P
-
G
V
--
E
-
V
------
A
F
DE
K
T
I
V
S
S
T
G
A
L
A
L
-
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
K
V
T
V
V
E
F
L
D
T
-
I
L
G
G
M
-
D
G
E
V
----
A
K
Q
L
Q
R
M
L
-
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
---
T
G
A
V
---
K
S
G
D
G
A
----
K
V
T
F
E
P
V
--
K
-
G
-
G
E
A
----
T
T
-
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
-
V
R
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
G
H
V
--
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
-
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
---
K
---
E
A
------------
17
PsiBlast_PDB
63.98
37%
-89
- C2 -
1V59
4
DLDH_YEAST
A:
[6-466]
---
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-
R
G
K
--------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
-
M
H
T
E
A
--
Q
K
R
G
I
-------
D
--
V
N
G
D
I
K
I
N
V
A
N
F
Q
----
K
A
K
D
D
A
V
K
Q
L
T
G
----
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
---
K
I
R
V
T
-
P
V
D
----------
G
L
E
----------
G
T
V
K
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
-
G
I
--
E
-
I
------
D
---
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
-
I
G
A
S
M
-
D
G
E
V
----
A
K
A
T
Q
K
F
L
-
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
---
I
-
S
A
---
K
R
N
-
D
D
KN
V
V
E
I
V
V
E
D
T
--
K
-
T
-
N
K
Q
----
E
N
-
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
-
T
F
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
G
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
-
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
---
K
---
E
-------------
92
PsiBlast_CBE
62.45
36%
-89
- C2 -
1BHY
1
?
A:
[6-463]
--
E
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y
K
-
T
--------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
V
I
-----
D
E
V
--
R
H
L
A
A
---
N
--
G
I
--
K
Y
P
E
P
E
L
D
I
D
M
L
R
----
A
Y
K
D
G
V
V
----
S
R
L
T
G
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
H
---
H
L
E
V
S
-
L
T
A
----------
G
D
A
YE
Q
A
A
P
TG
E
K
K
I
V
A
F
K
------
N
C
I
I
A
A
G
S
R
V
T
K
L
P
-
F
I
--
P
-
E
------
D
---
P
R
I
I
D
S
S
G
A
L
A
L
-
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
-
L
G
S
R
L
D
V
V
E
M
M
D
G
-
L
M
Q
G
A
-
D
R
D
L
----
V
K
V
W
Q
K
Q
N
-
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
---
V
-
A
V
---
E
P
K
-
E
D
----
G
V
Y
V
T
F
E
--
G
-
A
-
N
A
P
----
K
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
-
V
G
Q
-
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
A
Y
F
--
D
A
R
V
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
-
N
G
G
D
M
I
G
E
V
Y
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
T
L
G
E
S
I
---------------------
91
PsiBlast_CBE
61.11
36%
-88
- C2 -
1OJT
1
?
A:
[6-463]
--
E
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y
K
-
T
--------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
V
I
-----
D
E
V
--
R
H
L
A
A
---
N
--
G
I
--
K
Y
P
E
P
E
L
D
I
D
M
L
R
----
A
Y
K
D
G
V
V
----
S
R
L
T
G
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
H
---
H
L
E
V
S
-
L
T
A
----------
G
D
A
YE
Q
A
A
P
TG
E
K
K
I
V
A
F
K
------
N
C
I
I
A
A
G
S
R
V
T
K
L
P
-
F
I
--
P
-
E
------
D
---
P
R
I
I
D
S
S
G
A
L
A
L
-
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
-
L
G
S
R
L
D
V
V
E
M
M
D
G
-
L
M
Q
G
A
-
D
R
D
L
----
V
K
V
W
Q
K
Q
N
-
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
---
V
-
A
V
---
E
P
K
-
E
D
----
G
V
Y
V
T
F
E
--
G
-
A
-
N
A
P
----
K
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
-
V
G
Q
-
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
A
Y
F
--
D
A
R
V
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
-
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
T
L
G
E
S
I
---------------------