@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0501: (2016-04-23 )
MSSSNGRGGAGGVGGSSEHPQYPKVVLVTGACRFLGGYLTARLAQNPLINRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHAAAASYAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGSSPHDPVMFTEDSSSRRPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRLANMIGPAMDTTLSRYLAGPLVPTIFGRDARLQLLHEQDALGALERAAMAGKAGTFNIGADGILMLSQAIRRAGRIPVPVPGFGVWALDSLRRANHYTELNREQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDDYFRGRGLTPIIDPHRVRSWEGRAVGLAQRWGSRNPIPWSGLR
Atome Classification :
(20 SA)
.........10........20........30........40.......----.50........60--.----.---.-----..--...--70........80.-.-.......90........100...-.--...110....-----...120.......130........140..-.....150---.----------......160-----.......170.......180.......-190.......200.--..------..---------.--.----------210----..----.----.-...220---.........230-----......----...240......----.250......---.----.-260.......270..-.-....-280.......290.......300.......310.......320....-...330.......340.......350.......360.......370....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSSNGRGGAGGVGGSSEHPQY
P
K
V
V
L
V
T
G
A
C
R
F
L
G
G
Y
L
T
A
R
L
AQNPL----I
N
R
V
I
A
V
DAIAP
S
--
K
----
D
---
M
-----
L
R
--RM
G
--
R
A
E
F
V
R
A
D
IR
N
-
P
-
F
-
I
A
K
V
I
RNGE
V
D
T
V
V
H
A
A
A
ASYAP-R--SG
G
S
A
A
L
K
E
L
-----
N
V
M
G
A
M
Q
L
F
A
A
C
Q
KA-P
S
V
R
R
V
V
L
K
S
T
S
E
-
V
YGSSPHD---
P
----------
V
M
FTEDSSS-----RRPFSQGFPKDSL
D
I
E
G
Y
V
R
A
LGRRRP-
D
I
A
V
T
I
L
R
L
A
N
MIG--P
A
------
M
D
---------
T
--
T
----------
L
S
R
----
Y
L----A----G-PL
V
P
-----
T
IFG
R
D
A
R
L
Q
-------
L
L
H
E
Q
D
----
A
L
G
A
L
E
R
A
A
MAG----KAG-
T
F
NIGA---
D
----
G
-
I
L
M
L
S
Q
A
I
R
RAGRIP-V-PVP
G
-
F
G
V
W
A
L
D
S
L
R
RANH
Y
T
EL
N
R
E
Q
F
A
Y
LSYGRVM
D
T
T
R
M
R
V
E
LGYQPKW-T
T
V
E
A
F
D
D
Y
F
RGRGLTPII
D
P
H
RVRSWEGRA
V
G
L
A
Q
RWGSRNPIPWSGLR
40
HHSearch
82.20
22%
-86
- C1 -
1OC2
4
?
A:
[3-329]
---------------------
Q
F
K
N
I
I
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
V
Y
N
N
H
P
----
D
V
H
V
T
V
L
D
K
L
T
Y
A
--
G
NK--
A
---
N
-----
L
E
AI
L
G
D
--
R
V
E
L
V
V
G
D
I
A
D
-
A
E
L
-
V
D
K
L
A
--
A
K
A
D
A
I
V
H
Y
A
A
E
S
H
N
D
N
S
--
L
N
D
P
S
P
F
I
H
T
-----
N
F
I
G
T
Y
T
L
L
E
A
A
R
K
Y
--
D
I
-
R
F
H
H
V
S
T
D
E
-
V
Y
G
D
L
P
L
R
---
E
DLPGHGEGPG
E
K
F
T
A
E
T
N
Y
-------
N
P
S
S
P
Y
S
S
T
K
A
A
S
D
L
I
V
K
A
W
V
R
S
-
F
-
G
V
K
A
T
I
S
N
C
S
N
N
Y
G
--
P
Y
------
Q
H
---------
I
EK
F
----------
I
P
R
----
Q
I
T
N
I
L
A
----
G
-
I
K
P
K
-----
L
Y
G
E
G
K
N
V
R
D
-------
W
I
H
T
N
D
----
H
S
T
G
V
W
A
I
L
T
K
G
R---
M
G
E
-
T
Y
L
I
G
A
---
D
----
G
-
E
K
N
N
K
E
V
L
E
L
I
L
E
K
M
G
Q
-
P
K
D
A
-
Y
D
--------------
H
V
T
D
--
R
A
G
H
D
L
R
Y
A
I
D
A
S
K
L
R
D
E
L
G
W
T
P
Q
F
T
D
F
S
E
G
L
E
E
T
I
Q
W
Y
T
D
N
Q
D
W
W
------------------------------
33
HHSearch
82.01
24%
-98
* C1 *
1R6D
2
?
A:
[1-315]
-----------------------
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
Y
PDVP
A
D
E
V
I
V
L
D
S
L
T
Y
A
--
G
NRA-
N
---
L
AP---
V
D
--
A
D
P
--
R
L
R
F
V
H
G
D
I
R
D
-
A
G
L
-
L
A
R
E
L
R
--
G
V
D
A
I
V
H
F
A
A
E
S
H
V
D
-
R
S
-
I
A
G
A
S
V
F
T
E
T
-----
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
--
G
V
G
R
V
V
H
V
S
T
N
Q
-
V
Y
G
S
I
D
S
---------------
G
S
W
T
E
S
S
P
L
-------
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
-
Y
-
G
L
D
V
R
I
T
R
C
C
N
N
Y
G
--
P
Y
------
Q
H
---------
P
--
E
K
L
--------
I
P
L
----
F
V
T
N
L
L
D
----
G
-
G
T
L
P
-----
L
Y
G
D
G
A
N
V
R
E
-------
W
V
H
T
D
D
----
H
C
R
G
I
A
L
V
L
A
G
G
R---
A
G
E
-
I
Y
H
I
G
G
---
G
----
L
-
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
-
G
-
A
D
W
S
-
S
V
R
-------------
K
V
A
-
D
-
R
K
G
H
D
L
R
Y
S
L
D
G
G
K
I
E
R
E
L
G
Y
R
P
Q
V
-
S
F
A
D
G
L
A
R
T
V
R
W
Y
R
E
N
R
---------------------------------
41
HHSearch
76.76
21%
-86
- C1 -
4ZRM
3
?
A:
[4-310]
-----------------------
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
------
Y
G
V
I
V
V
D
N
L
S
S
G
--
K
----
V
---
E
-----
N
---
L
N
R
--
N
A
L
F
Y
E
Q
S
I
E
D
-
E
E
M
-
M
E
R
I
F
S
L
H
R
P
E
Y
V
F
H
L
A
A
Q
A
S
V
A
-
I
S
-
V
R
E
P
A
R
D
A
K
T
-----
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
--
G
V
K
K
F
I
F
S
S
T
G
G
A
I
Y
G
E
N
V
K
----
V
----------
F
P
T
P
E
T
E
I
P
-------
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
-
Y
-
G
L
K
Y
T
V
L
R
Y
A
N
V
Y
G
--
P
R
------
Q
D
---------
P
--
Y
GEAG
V
-----
V
A
I
F
T
E
R
M
L
----
R
----
G
-
E
E
V
H
-----
I
F
G
D
G
E
Y
V
R
D
-------
Y
V
Y
V
D
D
----
V
V
R
A
N
L
L
A
M
E
K
G
----
D
N
E
-
V
F
N
I
G
T
---
G
----
R
-
G
T
T
V
N
Q
L
F
K
L
L
K
E
I
T
-
G
Y
D
K
E
P
-
V
Y
K
-------------
P
P
R
----
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
P
K
V
-
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
T
----------------------------------
31
HHSearch
74.78
21%
-90
- C1 -
2HUN
1
?
A:
[3-318]
----------------------
S
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
H
P
----
D
W
E
V
I
N
I
D
K
L
G
Y
G
SN
P
----
A
NLK
D
-----
L
E
--
D
D
P
--
R
Y
T
F
V
K
G
D
V
A
D
-
Y
E
L
-
V
K
E
L
V
R
--
K
V
D
G
V
V
H
L
A
A
E
S
H
V
D
R
S
--
I
S
S
P
E
I
F
L
H
S
-----
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
-
N
P
E
V
R
F
V
H
V
S
T
D
E
-
V
Y
G
D
I
L
K
---------------
G
S
F
T
E
N
D
R
L
-------
M
P
S
S
P
Y
S
A
T
K
A
A
S
D
M
L
V
L
G
W
T
R
T
-
Y
-
N
L
N
A
S
I
T
R
C
T
N
N
Y
G
--
P
Y
------
Q
F
---------
P
EK
L
----------
I
P
K
----
T
I
I
R
A
S
L
----
G
-
L
K
I
P
-----
I
Y
G
T
---
V
R
D
-------
W
L
Y
V
E
D
----
H
V
R
A
I
E
L
V
L
L
K
G
E
---
S
R
E
-
I
Y
N
I
S
A
---
G
----
E
-
E
K
T
N
L
E
V
V
K
I
I
L
R
L
M
-
G
K
G
E
E
L
-
I
E
L
------------
V
E
D
R
----
P
G
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
D
L
K
W
R
P
K
Y
-
T
F
D
E
G
I
K
K
T
I
D
W
Y
L
K
N
E
W
W
W
------------------------------
18
PsiBlast_PDB
74.31
25%
-106
- C1 -
4EGB
19
?
A:
[27-288]
-------------------------
I
L
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
M
L
Q
S
Y
E
----
T
Y
K
I
I
N
F
D
A
L
T
Y
S
--
G
----
N
---
L
NNVKS
I
Q
--
D
H
P
--
N
Y
Y
F
V
K
G
E
I
Q
N
G
E
-
L
-
L
E
H
V
I
K
E
R
D
V
Q
V
I
V
N
F
A
A
E
S
-----------
I
P
F
Y
D
T
-----
N
V
I
G
T
V
T
L
L
E
L
V
K
K
Y
-
P
H
I
K
L
V
Q
V
-
S
T
D
E
-
V
Y
G
S
L
G
K
T
---
G
-----------
R
F
T
E
E
T
---------
P
L
A
P
N
S
P
Y
S
S
S
K
A
S
A
D
M
I
A
L
A
Y
Y
K
T
Y
Q
L
P
V
I
V
T
R
C
S
N
N
Y
G
--
P
Y
QYPEK
L
I
P
---------
L
--
M
----------
V
T
N
----
A
L
----
E
----
G
-
K
K
L
P
------
L
Y
G
D
G
L
N
V
R
D
------
W
L
H
V
T
D
----
H
C
S
A
I
D
V
V
L
H
K
G
----
R
V
G
E
V
Y
N
I
G
G
---
N
N
E
K
T
N
-
V
E
V
V
E
Q
I
I
T
L
L
G
K
------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.29
27%
-97
- C1 -
1XEL
5
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
S
A
T
-
V
Y
G
D
N
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
------
G
D
M
G
E
D
P
Q
G
IP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRDSL
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.19
27%
-98
- C1 -
1NAH
4
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
S
A
T
-
V
Y
G
D
N
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
------
G
D
M
G
E
D
P
Q
G
IP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRDSL
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
21
HHSearch
72.18
19%
-86
- C1 -
4EGB
19
?
A:
[24-340]
----------------------
A
M
N
I
L
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
M
L
Q
S
Y
E
----
T
Y
K
I
I
N
F
D
A
L
T
Y
S
GN
L
----
N
NVK
S
-----
I
Q
--
D
H
P
--
N
Y
Y
F
V
K
G
E
I
Q
N
-
G
E
L
-
L
E
H
V
I
K
E
R
D
V
Q
V
I
V
N
F
A
A
E
S
-----------
I
P
F
Y
D
T
-----
N
V
I
G
T
V
T
L
L
E
L
V
K
K
Y
--
P
H
I
K
L
V
Q
V
S
T
D
E
-
V
Y
G
S
L
G
K
T
--------------
G
R
F
T
E
E
T
P
L
-------
A
P
N
S
P
Y
S
S
S
K
A
S
A
D
M
I
A
L
A
Y
Y
K
T
-
Y
-
Q
L
P
V
I
V
T
R
C
S
N
N
Y
G
--
P
Y
------
Q
Y
---------
P
--
E
K
L
--------
I
P
L
----
M
V
T
N
A
L
E
----
G
-
K
K
L
P
-----
L
Y
G
D
G
L
N
V
R
D
-------
W
L
H
V
T
D
----
H
C
S
A
I
D
V
V
L
H
K
G
R---
V
G
E
-
V
Y
N
I
G
G
---
N
----
N
-
E
K
T
N
V
E
V
V
E
Q
I
I
T
L
L
G
K
-
T
K
K
D
-
I
E
--------------
Y
V
T
-
D
---
G
H
D
R
R
Y
A
I
N
A
E
K
M
K
N
E
F
D
W
E
P
K
Y
-
T
F
E
Q
G
L
Q
E
T
V
Q
W
Y
E
K
N
E
E
W
-------------------------------
4
PsiBlast_PDB
71.97
27%
-94
- C1 -
1LRJ
5
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
S
A
T
-
V
Y
G
D
N
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
------
G
D
MGEDPQGIP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRD
S
L
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.92
27%
-95
- C1 -
1UDC
8
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
S
A
T
-
V
Y
G
D
Q
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
------
G
D
M
G
E
D
P
Q
G
IP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRDSL
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.69
27%
-95
- C1 -
1LRK
5
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
S
A
T
-
V
Y
G
D
N
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
AH
P
S
------
G
D
MGEDPQGIP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRD
S
L
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.11
27%
-94
- C1 -
1UDA
6
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
S
A
T
-
V
Y
G
D
N
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
------
G
D
M
G
E
D
P
Q
G
IP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRDSL
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
27
HHSearch
70.19
18%
-88
- C1 -
4LW8
1
?
A:
[15-322]
-------------------
G
R
P
S
R
R
A
F
V
T
G
L
T
G
F
T
G
R
Y
M
A
E
R
L
Q
A
A
G
------
Y
D
V
W
G
T
V
A
P
G
T
P
--
R
----
P
---
A
-----
D
P
--
A
F
A
--
Q
C
T
L
L
P
V
D
L
L
D
-
A
E
A
-
M
R
A
A
A
A
D
A
R
P
D
A
V
V
H
L
A
A
R
A
---------
E
P
S
Q
T
Y
A
V
-----
N
I
V
G
T
R
N
L
L
A
A
L
S
G
L
D
R
R
P
S
A
V
L
L
A
S
S
A
N
-
I
Y
G
N
S
T
A
---------------
G
V
L
D
E
T
V
A
P
-------
A
P
A
N
D
Y
A
V
S
K
L
A
M
E
Y
A
A
K
L
W
A
---
D
-
R
L
P
I
V
I
A
R
P
F
N
Y
T
G
--
V
G
------
Q
S
---------
D
--
A
Y
L
--------
L
P
K
----
L
V
----
A
H
Y
A
R
N
-
A
P
R
I
-----
S
L
G
N
L
D
V
S
R
D
-------
F
S
D
V
R
D
----
V
T
A
A
Y
L
K
L
I
E
A
A
P---
A
G
E
-
T
F
N
V
C
S
---
E
----
R
-
A
Y
S
L
K
E
V
L
A
M
L
S
R
I
A
-
G
-
Y
V
I
D
-
V
T
I
-----------
D
P
R
F
V
---
R
H
N
E
V
K
S
L
S
G
S
R
D
K
L
R
R
A
V
G
E
L
P
V
T
-
P
L
D
E
T
L
R
W
M
V
D
A
M
R
A
A
----------------------------------
6
PsiBlast_PDB
70.01
27%
-97
- C1 -
1NAI
4
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
S
A
T
-
V
Y
G
D
N
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
------
G
D
MGEDPQGIP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRDSL
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
26
HHSearch
69.25
20%
-86
- C1 -
2BLL
-
ARNA_ECOLI
A:
[316-654]
-----------------------
M
R
V
L
I
L
G
V
N
G
F
I
G
N
H
L
T
E
R
L
L
R
E
D
H
-----
Y
E
V
Y
G
L
D
I
G
S
D
A
--
I
----
S
---
R
-----
F
L
--
N
H
P
--
H
F
H
F
V
E
G
D
I
S
I
-
H
S
E
W
I
E
Y
H
V
--
K
K
C
D
V
V
L
P
L
V
A
I
A
T
P
I
E
Y
--
T
R
N
P
L
R
V
F
E
L
-----
D
F
E
E
N
L
R
I
I
R
Y
C
V
K
Y
---
R
K
R
I
I
F
P
S
T
S
E
-
V
Y
G
M
C
S
D
---------------
K
Y
F
D
E
D
H
S
N
L
I
V
G
P
V
N
K
P
R
W
I
Y
S
V
S
K
Q
L
L
D
R
V
I
W
A
Y
G
E
K
-
E
-
G
L
Q
F
T
L
F
R
P
F
N
W
M
G
--
P
R
------
L
D
---------
N
--
L
NAARIGSS
R
A
I
T
Q
----
L
I
L
N
L
V
E
----
G
-
S
P
I
K
-----
L
I
D
G
G
K
Q
K
R
C
-------
F
T
D
I
R
D
----
G
I
E
A
L
Y
R
I
I
E
N
A
GNRC
D
G
E
-
I
I
N
I
G
N
---
P
----
E
N
E
A
S
I
E
E
L
G
E
M
L
L
A
S
F
-
E
-
K
H
P
L
R
H
H
F
P
P
F
A
G
F
-
R
V
V
-------------
V
E
H
R
K
P
S
I
R
N
A
H
R
C
L
D
W
E
P
K
I
-
D
M
Q
E
T
I
D
E
T
L
D
F
F
L
R
T
V
D
--------------------------------
13
PsiBlast_PDB
69.11
27%
-97
- C1 -
2UDP
4
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
S
A
T
-
V
Y
G
D
Q
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
AH
P
S
------
G
D
M
G
E
D
P
Q
G
IP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRD
S
L
A
I
F
G
N
D
Y
P
T
E
DGTGVRD
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
68.94
27%
-95
- C1 -
1LRL
5
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
S
A
T
-
V
Y
G
D
N
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
------
G
D
M
G
E
D
P
Q
G
IP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRD
S
L
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
36
HHSearch
68.70
17%
-80
- C1 -
2C5A
13
GME_ARATH
A:
[22-343]
---------------
E
Q
Y
W
P
S
E
N
L
K
I
S
I
T
G
A
G
G
F
I
A
S
H
I
A
R
R
L
K
H
E
G
------
H
Y
V
I
A
S
D
W
K
K
N
E
--
H
----
M
---
T
-----
E
---
D
M
F
--
C
D
E
F
H
L
V
D
L
R
V
-
M
E
N
-
C
L
K
V
T
E
--
G
V
D
H
V
F
N
L
A
A
D
M
G
G
M
-
G
FI
Q
S
N
H
S
V
I
M
Y
N
-----
N
T
M
I
S
F
N
M
I
E
A
A
R
I
N
--
G
I
K
R
F
F
Y
A
S
S
A
C
-
I
Y
P
E
F
K
Q
L
ETT
N
----------
V
S
L
K
E
S
D
A
W
-----
P
A
E
P
Q
D
A
F
G
L
E
K
L
A
T
E
E
L
C
K
H
Y
N
K
D
-
F
-
G
I
E
C
R
I
G
R
F
H
N
I
Y
G
--
P
F
------
G
T
---------
W
--
K
GGREK
A
----
P
A
A
----
F
C
----
R
K
A
Q
T
S
T
D
R
F
E
-----
M
W
G
D
G
L
Q
T
R
S
-------
F
T
F
I
D
E
----
C
V
E
G
V
L
R
L
T
K
S
D
----
F
R
E
-
P
V
N
I
G
S
---
D
----
E
-
M
V
S
M
N
E
M
A
E
M
V
L
S
F
E
E
K
-
K
L
P
I
-
H
H
I
-------------
P
G
-----
P
E
G
V
R
G
R
N
S
D
N
N
L
I
K
E
K
L
G
W
A
P
N
M
-
R
L
K
E
G
L
R
I
T
Y
F
W
I
K
E
Q
I
E
--------------------------------
1
PsiBlast_PDB
68.65
27%
-97
- C1 -
1KVS
5
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
R
S
V
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
T
A
T
-
V
Y
G
D
N
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
AH
P
S
------
G
D
M
G
E
D
P
Q
G
IP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRDSL
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.31
27%
-92
- C1 -
1A9Y
4
GALE_ECOLI
A:
[3-284]
-------------------------
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
------
H
D
V
I
I
L
D
N
L
C
N
S
--
K
RSV
L
P
---
V
-----
I
E
--
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
-
E
A
L
-
M
T
E
I
L
H
D
H
A
I
D
T
V
I
H
F
A
G
L
-----
K
--
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
-
M
R
A
-
A
N
V
K
N
F
I
F
S
S
A
A
T
-
V
Y
G
D
Q
P
K
I
---
P
------------
Y
V
E
S
F
P
T
-----
G
T
P
Q
S
P
-
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
P
-
D
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
------
G
D
M
G
E
D
P
Q
G
IP
N
--
N
----------
L
M
P
----
Y
I
----
A
----
Q
-
V
A
V
G
RRD
S
L
A
I
F
G
N
D
Y
P
T
E
DG
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
----
G
V
H
-
I
Y
N
L
G
A
G
V
G
N
----
S
-
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
-
V
--------------------------------------------------------------------------------------------------------