@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0524: (2016-04-23 )
MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVGGTPRFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARGLSFGAPTPAETQLAGEIIGRVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLGLCDDPQRPASPRSQSSRGLPSSPGVTGAAAADTIVLPYNDIDAVQQTFARFGEQIAAVITEASPGNMGVVPPGPGFNAALRAITAEHGALLILDEVMTGFRVSRSGWYGIDPVPADLFAFGKVMSGGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGNPVAVAAGLATLRAADDAVYTALDANADRLAGLLSEALTDAVVPHQISRAGNMLSVFFGETPVTDFASARASQTWRYPAFFHAMLDAGVYPPCSAFEAWFVSAALDDAAFGRIANALPAAARAAAQERPA
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280-.---........290.......300.......310.......320........330.......340...-.-...--350..-----......360.-...--...370----.----.--.....---380.........390....---....400.......410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
S
T
E
Q
A
T
S
R
VRGAA
R
T
S
A
Q
L
F
E
A
A
C
S
VIPGGVNS
P
V
R
A
F
TAVGGTP
R
F
I
TEAH
G
C
W
L
I
DADG
N
R
Y
V
D
L
V
CSWG
P
M
I
LGHA
H
P
A
V
V
E
A
V
A
K
A
A
ARGLSFGAPT
P
A
E
T
Q
L
A
G
E
I
I
GRVAP
V
E
R
I
R
L
VNSG
T
E
A
T
M
S
A
V
R
L
ARGFTGR
A
K
I
V
K
F
SGCYHG
H
V
D
A
L
L
ADAGSG
V
A
T
LGLCDDPQRPASPRSQSSRGLPSSPGVTGAAAA
D
T
I
V
L
PYN
D
I
D
A
V
Q
Q
T
F
A
R
F
G
E
Q
I
A
A
V
I
TEASPGNMGVVPPGP
G
F
N
A
A
L
R
A
I
T
AEH
G
A
L
L
I
L
D
E
V
M
TG
F
R
VSRS---G---WYGIDPV
P
A
D
L
F
A
F
G
K
V
MSGGM
P
A
A
AFG
G
R
A
E
V
M
Q
R
LAP-LGP
V
Y
QAGTLSGN
P
V
A
V
A
A
G
L
A
T
L
R-A-AD
D
--
A
-
V
Y
T
-----ALDA
N
A
D
R
L
A
-
G
L
L
--
S
E
A
L
T
D
----
A
----
V
--
V
P
H
Q
I
---
S
--RAG
N
M
L
S
V
FF-GETP
V
---
T
D
F
A
S
ARASQTWR
Y
P
A
F
F
H
A
M
L
DAGVYPP
C
S
A
F
E
A
W
F
V
S
A
AL
D
D
A
A
F
G
R
I
A
N
A
L
P
A
A
A
R
A
AAQERPA
105
HHSearch
95.51
51%
-108
- C2 -
5I92
2
?
A:
[9-434]
--------------
M
S
R
S
E
T
L
F
N
N
A
Q
K
H
I
P
G
G
V
N
S
P
V
R
A
F
K
S
V
G
G
T
P
L
F
F
K
H
A
E
G
A
Y
V
L
D
E
D
D
K
R
Y
V
D
Y
V
G
S
W
G
P
M
I
L
G
H
S
H
P
D
V
L
D
A
V
R
R
Q
L
D
H
G
L
S
Y
G
A
P
T
A
L
E
V
E
M
A
D
L
V
C
S
M
V
P
S
M
E
M
V
R
M
V
S
S
G
T
E
A
T
M
S
A
I
R
L
A
R
G
Y
T
G
R
D
S
I
I
K
F
E
G
C
Y
H
G
H
S
D
S
L
L
V
K
A
G
S
---
T
F
------------------
G
V
P
N
S
P
G
V
P
A
A
F
A
K
H
T
L
T
L
P
F
N
D
I
E
A
V
R
K
T
L
G
E
V
G
K
E
V
A
C
I
I
V
E
P
V
A
G
N
M
N
C
V
P
P
A
P
G
F
L
E
G
L
R
E
A
C
D
E
H
G
V
V
L
I
F
D
E
V
M
T
G
F
R
V
A
L
G
---
G
---
A
Q
A
Y
Y
G
V
T
P
D
L
S
T
F
G
K
I
I
G
G
G
M
P
V
G
A
F
G
G
K
R
E
I
M
Q
Q
I
S
P
-
L
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
T
T
L
R
-
L
-
I
S
R
--
P
G
F
H
D
-----
E
L
T
A
Y
T
T
R
M
L
-
D
G
L
--
Q
Q
R
A
D
A
----
A
----
G
--
I
P
F
V
T
---
T
--
Q
A
G
G
M
F
G
L
Y
F
-
S
G
A
D
A
I--
V
T
F
E
D
V
M
A
S
D
V
E
R
F
K
R
F
F
H
L
M
L
D
G
G
V
Y
L
A
P
S
A
F
E
A
G
F
T
S
I
A
H
G
D
K
E
L
E
I
T
L
N
A
A
E
K
A
F
A
A
L
------
3
PsiBlast_PDB
94.71
49%
-105
- C2 -
2E7U
4
GSA_THET8
A:
[6-423]
-----------------
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
R
A
F
K
A
V
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
R
G
L
T
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
------------------
G
V
P
S
S
A
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
A
K
A
-
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
R
L
A
F
G
---
G
---
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
K
V
A
P
-
L
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
-
L
-
L
E
E
N
P
G
-
Y
Y
A
-----
Y
L
E
D
L
G
A
R
L
E
-
A
G
L
--
K
E
V
L
K
E
----
K
----
G
--
L
P
H
T
V
---
N
--
R
V
G
S
M
I
T
V
F
F
-
T
E
G
P
V
---
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
----------
1
PsiBlast_PDB
93.41
47%
-100
- C2 -
3BS8
1
GSA_BACSU
A:
[9-434]
--------
M
R
S
Y
E
K
S
K
T
A
---
F
K
E
A
Q
K
L
M
P
G
G
V
N
S
P
V
R
A
F
K
S
V
D
M
D
P
I
F
M
E
R
G
K
G
S
K
I
F
D
I
D
G
N
E
Y
I
D
Y
V
L
S
W
G
P
L
I
L
G
H
T
N
D
R
V
V
E
S
L
K
K
V
A
E
Y
G
T
S
F
G
A
P
T
E
V
E
N
E
L
A
K
L
V
I
D
R
V
P
S
V
E
I
V
R
M
V
S
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
R
N
K
I
L
K
F
E
G
C
Y
H
G
H
G
D
S
L
L
I
K
A
G
S
G
V
A
T
L
G
L
------------------
P
D
S
P
G
V
P
E
G
I
A
K
N
T
I
T
V
P
Y
N
D
L
E
S
V
K
L
A
F
Q
Q
F
G
E
D
I
A
G
V
I
V
E
P
V
A
G
N
M
G
V
V
P
P
Q
E
G
F
L
Q
G
L
R
D
I
T
E
Q
Y
G
S
L
L
I
F
D
E
V
M
T
G
F
R
V
D
Y
N
C
A
Q
G
---
Y
F
G
V
T
P
---
D
L
T
C
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
K
A
E
I
M
E
Q
I
A
P
-
S
G
P
I
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
L
E
T
L
K
-
Q
-
L
T
P
--
D
-
S
Y
K
-----
N
F
I
K
K
G
D
R
L
E
-
E
G
I
--
S
K
A
A
E
A
----
H
----
G
--
I
P
H
T
F
---
N
--
R
A
G
S
M
I
G
F
F
F
-
T
N
E
P
V
---
I
N
Y
E
T
A
K
A
S
D
L
K
L
F
A
S
Y
Y
K
G
M
A
N
E
G
V
F
L
P
P
S
Q
F
E
G
L
F
L
S
T
A
H
T
D
E
---
D
I
E
N
T
I
Q
A
A
E
K
V
F
A
E
----
21
PsiBlast_CBE
91.99
49%
-108
- C2 -
5I92
3
?
D:
[12-426]
-----------------
S
E
T
L
F
N
N
A
Q
K
H
I
P
G
G
V
N
S
P
V
R
A
F
K
S
V
G
G
T
P
L
F
F
K
H
A
E
G
A
Y
V
L
D
E
D
D
K
R
Y
V
D
Y
V
G
S
W
G
P
M
I
L
G
H
S
H
P
D
V
L
D
A
V
R
R
Q
L
D
H
G
L
S
Y
G
A
P
T
A
L
E
V
E
M
A
D
L
V
C
S
M
V
P
S
M
E
M
V
R
M
V
S
S
G
T
E
A
T
M
S
A
I
R
L
A
R
G
Y
T
G
R
D
S
I
I
K
F
E
G
C
Y
H
G
H
S
D
S
L
L
V
K
A
G
S
---
T
F
------------------
G
V
P
N
S
P
G
V
P
A
A
F
A
K
H
T
L
T
L
P
F
N
D
I
E
A
V
R
K
T
L
G
E
V
G
K
E
V
A
C
I
I
V
E
P
V
A
G
N
M
N
C
V
P
P
A
P
G
F
L
E
G
L
R
E
A
C
D
E
H
G
V
V
L
I
F
D
E
V
M
T
G
F
R
V
A
L
G
---
G
AQA
Y
Y
G
V
T
P
---
D
L
S
T
F
G
K
I
I
G
G
G
M
P
V
G
A
F
G
G
K
R
E
I
M
Q
Q
I
S
P
-
L
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
T
T
L
R
L
I
-
S
R
P
--
G
-
F
H
D
-----
E
L
T
A
Y
T
T
R
M
L
-
D
G
L
--
Q
Q
R
A
D
A
----
A
----
G
--
I
P
F
V
T
---
T
--
Q
A
G
G
M
F
G
L
Y
F
S
G
A
D
A
I
---
V
T
F
E
D
V
M
A
S
D
V
E
R
F
K
R
F
F
H
L
M
L
D
G
G
V
Y
L
A
P
S
A
F
E
A
G
F
T
S
I
A
H
G
D
K
E
L
E
I
T
L
N
A
--------------
2
PsiBlast_PDB
91.34
49%
-110
- C2 -
5I92
2
?
A:
[12-426]
-----------------
S
E
T
L
F
N
N
A
Q
K
H
I
P
G
G
V
N
S
P
V
R
A
F
K
S
V
G
G
T
P
L
F
F
K
H
A
E
G
A
Y
V
L
D
E
D
D
K
R
Y
V
D
Y
V
G
S
W
G
P
M
I
L
G
H
S
H
P
D
V
L
D
A
V
R
R
Q
L
D
H
G
L
S
Y
G
A
P
T
A
L
E
V
E
M
A
D
L
V
C
S
M
V
P
S
M
E
M
V
R
M
V
S
S
G
T
E
A
T
M
S
A
I
R
L
A
R
G
Y
T
G
R
D
S
I
I
K
F
E
G
C
Y
H
G
H
S
D
S
L
L
V
K
A
G
S
---
T
F
------------------
G
V
P
N
S
P
G
V
P
A
A
F
A
K
H
T
L
T
L
P
F
N
D
I
E
A
V
R
K
T
L
G
E
V
G
K
E
V
A
C
I
I
V
E
P
V
A
G
N
M
N
C
V
P
P
A
P
G
F
L
E
G
L
R
E
A
C
D
E
H
G
V
V
L
I
F
D
E
V
M
T
G
F
R
V
A
L
G
---
G
A
Q
A
Y
Y
G
V
T
P
---
D
L
S
T
F
G
K
I
I
G
G
G
M
P
V
G
A
F
G
G
K
R
E
I
M
Q
Q
I
S
P
-
L
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
T
T
L
R
L
I
-
S
R
P
--
G
-
F
H
D
-----
E
L
T
A
Y
T
T
R
M
L
-
D
G
L
--
Q
Q
R
A
D
A
----
A
----
G
--
I
P
F
V
T
---
T
--
Q
A
G
G
M
F
G
L
Y
F
S
G
A
D
A
I
---
V
T
F
E
D
V
M
A
S
D
V
E
R
F
K
R
F
F
H
L
M
L
D
G
G
V
Y
L
A
P
S
A
F
E
A
G
F
T
S
I
A
H
G
D
K
E
L
E
I
T
L
N
A
--------------
111
HHSearch
91.21
50%
-96
- C2 -
2E7U
4
GSA_THET8
A:
[3-423]
--------------
R
P
I
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
R
A
F
K
A
V
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
R
G
L
T
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
------------------
V
P
S
S
A
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
-
A
L
H
E
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
R
L
A
F
G
---
G
---
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
K
V
A
P
-
L
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
-
L
-
L
E
E
--
N
---
P
-----
G
Y
Y
A
Y
L
E
D
L
G
-
A
R
L
--
E
A
G
L
K
E
V
L
K
E
K
----
G
--
L
P
H
T
V
---
N
--
R
V
G
S
M
I
T
V
F
F
-
T
E
G
P
V
---
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
----------
120
Fugue
87.74
45%
-98
- C2 -
2GSA
2
GSA_SYNP6
A:
[6-432]
------------
F
K
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
------------------
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
---
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
--
P
G
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
-
D
G
L
--
L
A
I
A
Q
E
----
T
----
G
--
H
A
A
C
G
---
G
--
Q
V
S
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
------
112
HHSearch
85.98
45%
-100
- C2 -
3FQ8
2
GSA_SYNP6
A:
[4-426]
---------------
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
------------------
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
---
G
---
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
------
P
-----
G
T
Y
E
Y
L
D
Q
I
T
-
K
R
L
--
S
D
G
L
L
A
----
I
A
Q
E
T
G
--
H
A
A
C
G
---
G
--
Q
V
S
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
-------
30
PsiBlast_CBE
85.21
46%
-102
- C2 -
3FQ7
2
GSA_SYNP6
B:
[6-407]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
VQE
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
AI
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
31
PsiBlast_CBE
85.13
46%
-104
- C2 -
3FQA
3
GSA_SYNP6
B:
[6-407]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
---
G
VQE
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
AI
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
11
PsiBlast_PDB
85.11
46%
-102
- C2 -
3FQ7
2
GSA_SYNP6
A:
[6-407]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
8
PsiBlast_PDB
84.98
46%
-105
- C2 -
2HOZ
3
GSA_SYNP6
A:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
117
HHSearch
84.62
43%
-97
- C2 -
2EPJ
1
GSA_AERPE
A:
[9-432]
--------------
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
-
A
A
V
K
-
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
------------------
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
---
G
---
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
-
A
-
L
E
E
--
E
P
V
Y
S
-----
V
S
R
E
A
A
K
A
L
E
-
E
A
A
--
S
E
V
L
D
R
----
T
----
G
--
L
P
Y
T
I
N
R
V
E
S-
M
M
Q
L
F
I
G
V
E
E
-
V
S
N
A
A
---
Q
-
A
---
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
-----
24
PsiBlast_CBE
84.55
46%
-104
- C2 -
2GSA
2
GSA_SYNP6
B:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
VQE
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
AI
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
22
PsiBlast_CBE
84.29
46%
-103
- C2 -
4GSA
2
GSA_SYNP6
B:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
VQE
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
AI
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
27
PsiBlast_CBE
84.26
46%
-105
- C2 -
2HOZ
2
GSA_SYNP6
B:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
-------------------------
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
34
PsiBlast_CBE
84.14
44%
-102
- C2 -
2ZSM
4
GSA_AERPE
B:
[10-407]
---------------
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------------------------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
---
G
---
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
-
A
-
L
E
E
--
E
P
V
Y
S
-----
V
S
R
E
A
A
K
A
L
E
-
E
A
A
--
S
E
V
L
D
R
----
T
----
G
--
L
P
Y
T
I
---
N
--
R
V
E
S
M
M
Q
L
F
I
-
G
V
E
E
V
---
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
------------------------------
32
PsiBlast_CBE
83.73
45%
-104
- C2 -
3FQ8
2
GSA_SYNP6
B:
[6-407]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
---
G
VQE
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
AI
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
13
PsiBlast_PDB
83.53
46%
-103
- C2 -
3FQA
3
GSA_SYNP6
A:
[6-407]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
16
PsiBlast_PDB
83.46
44%
-99
- C2 -
2EPJ
1
GSA_AERPE
A:
[9-407]
--------------
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------------------------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
---
G
---
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
-
A
-
L
E
E
--
E
P
V
Y
S
-----
V
S
R
E
A
A
K
A
L
E
-
E
A
A
--
S
E
V
L
D
R
----
T
----
G
--
L
P
Y
T
I
---
N
--
R
V
E
S
M
M
Q
L
F
I
-
G
V
E
E
V
---
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
------------------------------
17
PsiBlast_PDB
83.40
44%
-99
- C2 -
2ZSL
1
GSA_AERPE
A:
[9-407]
--------------
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------------------------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
---
G
---
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
-
A
-
L
E
E
--
E
P
V
Y
S
-----
V
S
R
E
A
A
K
A
L
E
-
E
A
A
--
S
E
V
L
D
R
----
T
----
G
--
L
P
Y
T
I
---
N
--
R
V
E
S
M
M
Q
L
F
I
-
G
V
E
E
V
---
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
------------------------------
23
PsiBlast_CBE
82.75
46%
-100
- C2 -
3GSB
3
GSA_SYNP6
B:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
VQE
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
AI
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
14
PsiBlast_PDB
82.66
45%
-101
- C2 -
3FQ8
2
GSA_SYNP6
A:
[6-407]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
33
PsiBlast_CBE
82.63
44%
-98
- C2 -
2ZSM
4
GSA_AERPE
C:
[10-407]
---------------
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------------------------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
---
G
---
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
-
A
-
L
E
E
--
E
P
V
Y
S
-----
V
S
R
E
A
A
K
A
L
E
-
E
A
A
--
S
E
V
L
D
R
----
T
----
G
--
L
P
Y
T
I
---
N
--
R
V
E
S
M
M
Q
L
F
I
-
G
V
E
E
V
---
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
------------------------------
9
PsiBlast_PDB
82.47
46%
-100
- C2 -
2HP1
3
GSA_SYNP6
A:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
5
PsiBlast_PDB
82.38
46%
-99
- C2 -
4GSA
2
GSA_SYNP6
A:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
12
PsiBlast_PDB
82.28
46%
-97
- C2 -
3USF
3
GSA_SYNE7
A:
[6-407]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
10
PsiBlast_PDB
82.23
46%
-102
- C2 -
2HP2
3
GSA_SYNP6
A:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
25
PsiBlast_CBE
82.14
46%
-101
- C2 -
2HP2
3
GSA_SYNP6
B:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
VQE
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
AI
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
18
PsiBlast_PDB
82.05
44%
-98
- C2 -
2ZSM
2
GSA_AERPE
A:
[5-407]
----------
V
L
A
S
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------------------------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
---
G
---
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
-
A
-
L
E
E
--
E
P
V
Y
S
-----
V
S
R
E
A
A
K
A
L
E
-
E
A
A
--
S
E
V
L
D
R
----
T
----
G
--
L
P
Y
T
I
---
N
--
R
V
E
S
M
M
Q
L
F
I
-
G
V
E
E
V
---
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
------------------------------
6
PsiBlast_PDB
82.04
46%
-102
- C2 -
3GSB
3
GSA_SYNP6
A:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
------------------
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
29
PsiBlast_CBE
80.76
46%
-108
- C2 -
3USF
3
GSA_SYNE7
B:
[6-407]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
-------------------------------------------
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
45
PsiBlast_CBE
80.21
31%
-109
- C2 -
4AO9
3
BFAT_VARPD
B:
[33-439]
------
A
Y
R
R
F
T
D
A
N
P
A
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
V
-------------
L
G
F
G
A
R
P
S
P
T
T
V
P
-------------------
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
-
R
L
A
P
H
---
G
---
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
------
T
--
K
-
L
F
T
PEAAG
A
L
A
E
R
G
E
A
L
R
-
A
R
L
--
N
A
L
C
A
N
----
E
----
G
--
V
A
M
Q
F
---
T
--
G
I
G
S
L
M
N
A
H
F
-
V
Q
G
D
V
RSS
E
D
L
A
A
V
D
G
R
--
L
R
Q
L
L
F
F
H
-
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
I
-------------
46
PsiBlast_CBE
79.67
31%
-107
- C2 -
4AO9
2
BFAT_VARPD
A:
[33-439]
------
A
Y
R
R
F
T
D
A
N
P
A
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
V
-------------
L
G
F
G
A
R
P
S
P
T
T
V
P
-------------------
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
-
R
L
A
P
H
---
G
---
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
------
T
--
K
-
L
F
T
P
E
A
A
G
A
L
A
E
R
G
E
A
L
R
-
A
R
L
--
N
A
L
C
A
N
----
E
----
G
--
V
A
M
Q
F
---
T
--
G
I
G
S
L
M
N
A
H
F
-
V
Q
G
D
V
RSS
E
D
L
A
A
V
D
G
R
--
L
R
Q
L
L
F
F
H
-
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
I
-------------
26
PsiBlast_CBE
78.95
46%
-106
- C2 -
2HP1
3
GSA_SYNP6
B:
[11-412]
-----------------
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
-----------------------------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
V
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
L
-
L
R
Q
P-
G
-
T
Y
E
-----
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
----
A
----
A
--
C
G
G
Q
V
---
S
-----
G
M
F
G
F
F
F
-
T
E
G
P
V
---
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
--------------------------
15
PsiBlast_PDB
78.12
46%
-106
- C2 -
2CFB
1
GSA_THEEB
A:
[19-399]
----------------------------------------------
P
I
V
F
D
H
V
K
G
A
H
I
W
D
V
D
G
N
Q
Y
I
D
Y
V
G
S
W
G
P
A
I
V
G
H
A
H
P
E
V
I
D
A
L
H
A
A
L
E
K
G
T
S
F
G
A
P
C
L
L
E
N
I
L
A
E
M
V
I
A
A
V
P
S
V
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
Q
R
E
K
V
I
K
F
E
G
C
Y
H
G
H
A
----------------------------------------------
A
T
L
T
A
P
Y
N
D
L
E
A
V
S
R
L
F
E
Q
Y
P
N
D
I
A
G
V
I
L
E
P
V
V
G
N
A
G
F
I
P
P
D
A
G
F
L
E
G
L
R
E
L
T
K
Q
Y
G
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
---
G
A
Q
E
K
F
G
V
T
P
---
D
L
T
T
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
R
A
E
I
M
K
M
V
A
P
-
A
G
P
-----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
-
I
L
S
R
P
--
G
-
S
Y
E
-----
H
L
----
D
R
I
T
-
G
K
L
--
V
Q
G
L
L
D
----
A
----
A
R
E
F
G
H
E
V
---
C
G
G
H
I
S
G
M
F
G
L
F
F
-
T
A
G
P
V
---
T
N
Y
E
Q
A
K
Q
S
D
L
K
K
F
A
A
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
A
D
I
E
R
------------------