@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0575c: (2016-04-23 )
MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMIDFWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDVFRRMVGDDFTSLPRGDLAAAIYTTIEDQVETIFDDSIATIDEHRDGVRLTFERTAPRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGYRPRDERSYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDNPGVAPKDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRGRVLLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGGDHRRAFDAYEKRLRPFIEGKQASAAKFIWFFATRTRFGLWFRNVAMRTMNFGPLATLFAGSVRDDFELPDYTW
Atome Classification :
(20 SA)
-------.........10........20.-----.-.-..-----...30..--..-..----..------40-.....-....50........60.......-.-70-----....--.-...-80-..---......-.90....-.----..--.100.......110.-.--.------------.---...120........----------------------------------------------130..--.....140--.------.----.---..--------------------------------------------..--..150.......160..-..--.----..-------------170.....--.--..180....-..--.----190---.----...---------.....200--.-.-------.....210-----..------..-------...-220------...-.---.------------.----.--230---..-------------------.--.-.....240-----.---.-----.-.-..--..-----250.--------.....-.260.----....-...270----------....-.-.-...---280.......290.......300.......310.--..-----..-..320....----...330----------.......340.......350..-......360..-------.....370....--------...380......------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------
M
K
V
A
ISGAG
V
A
G
A
A
L
A
H
W
L
Q
RT-----G-H-T
P
-----
T
V
I
ERAP--KF-RT----G
G
------
Y
--
M
I
D
FW-G
V
G
Y
Q
V
A
K
RMG
I
T
D
Q
I
A
A
AG
Y
H
M
-
E
-
H
V
-----
R
SVG--P-TG
K
-
V
--
K
A
---
D
L
G
V
D
V
-
F
R
R
M
VGD-D----FT--SLPR
G
D
L
A
A
A
I
Y
T
T
I
-
E
--
D
------------
Q
---
V
E
T
I
F-DDSI
A
T
I
D
----------------------------------------------EHRD
G
--
V
R
L
T
F
E----R------T----A---PR--------------------------------------------
D
F
--
D
L
V
I
GAD
G
L
H
S
N
V
R
R
L
V-FG--P----E
R
-------------
D
-
F
E
H
Y
LG--
C
--
K
V
A
A
C
V
VDG-YR--P----R-----D----ER
S
---------
Y
V
L
Y
N
T
V
D
--
R
-
Q
-------
L
A
R
F
ALRG-----D
R
------
T
M
-------
F
L
F
-
V
F
R
------AEH-D---N------------P----G--V-----A
P
-------------------
K
--
D
-
E
L
R
D
Q
F-G-----D---V-----G-W-ES--
R
D
-----
I
L
A
A
--------
L
D
D
V
E
-
D
L
Y
-
F
----
D
V
V
S
-
Q
I
R
M
------------
D
RWS-R-G-
R
V
L
---
L
I
GD
A
A
G
C
I
S
L
LGGEGT
G
L
A
I
T
E
A
Y
V
L
A
G
E
L
A
RA--GG-----D
H
-
R
R
A
F
D
A
Y
E
K
----
R
L
R
P
F
I----------EGKQASA
A
K
F
I
W
F
F
ATRT-
R
F
G
-
L
W
F
R
N
V
A
M
R
TM-------NFG
P
L
A
T
L
F
AGS--------VRDDFELPDYTW------------------------------
13
PsiBlast_PDB
94.95
24%
-89
- C1 -
2RGJ
1
?
A:
[5-379]
-------
I
D
I
L
I
A
G
A
G
I
G
G
L
S
C
A
L
A
L
H
Q
A
-----
G
I
G
-
K
V
-----
T
L
L
E
S
S
S
--
E
I
-
R
P
----
L
G
------
V
--
G
I
N
I
Q
-
P
A
A
V
E
A
L
A
E
L
G
L
G
P
A
L
A
A
T
A
I
P
T
-
H
-
E
L
-----
R
Y
I
D
--
Q
-
S
G
A
-
T
V
W
S
E
---
P
R
G
V
E
A
------
G
N
-
A
----
Y
P
Q
Y
S
I
H
R
G
E
L
Q
M
I
L
L
A
A
V
-
R
--
E
------------
R
---
L
G
Q
Q
A
-
V
R
T
G
L
G
V
E
R
I
--------------------------------------------
E
E
R
D
G
--
R
V
L
I
G
A
----
R
------
D
----
G
H
G
K
P
Q
--------------------------------------------
A
L
G
A
D
V
L
V
G
A
D
G
I
H
S
A
V
R
A
H
L
-
H
P
--
D
----
Q
R
-------------
P
-
L
S
H
G
-
G
--
I
--
T
M
W
R
G
V
T
E
F
-
D
R
--
F
----
L
-----
D
----
G
K
T
---------
M
I
V
A
N
D
E
H
--
W
-
S
R
L
V
A
Y
P
I
S
A
R
H
A
A
E
G
------
K
------
S
L
-------
V
N
W
-
V
C
M
V
P
SAAV
G
Q
L
-
D
---
N
------------
E
----
A
--
D
-----
W
N
-------------------
R
--
D
G
R
L
E
D
V
L
-
P
FFADW
D
---
L
-----
G
-
W
F
D
I
--
R
D
-----
L
L
T
R
--------
N
Q
L
I
---
L
Q
-
Y
----
P
M
V
D
-
R
D
P
L
------------
P
H
W
G
-
R
-
G
-
R
I
T
---
L
L
G
D
A
A
H
L
M
Y
P
M
G
A
N
G
A
S
Q
A
I
L
D
G
I
E
L
A
A
A
L
A
R
---
N
A
-----
D
V
-
A
A
A
L
R
E
Y
E
E
----
A
R
R
P
-----------------
T
A
N
K
I
I
--
L
A
N
R
E
-
R
E
K
E
E
W
A
A
A
S
R
P
------------------------------------------------------------------------
17
PsiBlast_PDB
92.04
24%
-90
- C1 -
3RP7
2
HPXO_KLEP7
A:
[25-406]
--------
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
-----
G
-
I
-
D
C
-----
D
V
Y
E
A
V
K
--
E
I
-
K
-------------
A
--
A
I
S
V
W
-
P
N
G
V
K
C
M
A
H
L
G
M
G
D
I
M
E
T
F
G
G
P
L
-
R
-
R
M
A
Y
R
D
F
R
S
-------
G
E
-
N
--
M
T
---
Q
F
S
L
A
P
-
L
I
E
R
T
G
S
-
R
----
P
C
--
P
V
S
R
A
E
L
Q
R
E
M
L
D
Y
W
G
R
--
D
------------
S
---
V
Q
--
F
-
G
K
R
V
T
R
C
E
----------------------------------------------
E
D
A
D
G
--
V
T
V
W
F
T
----
D
------
G
----
S
---
S
A
--------------------------------------------
S
G
--
D
L
L
I
A
A
D
G
S
H
S
A
L
R
P
W
V
-
L
G
F
T
P
----
Q
R
-------------
R
-
Y
A
G
Y
V
N
--
W
--
N
G
L
V
E
I
D
E
A
-
L
A
--
P
----
G
-----
D
----
Q
-----------
W
T
T
F
V
G
E
G
--
K
-
R
-------
V
S
L
M
P
V
S
A
-----
G
R
------
F
Y
-------
F
F
F
--------------
D
---
V
------------
P
----
L
--
P
-----
A
G
-------------------
L
--
A
-
E
D
R
D
T
L
R
A
-----
D
---
L
S
R
Y
F
A
G
-
W
-
A
P
P
V
Q
K
-----
L
I
A
A
--------
L
D
P
Q
T
-
T
N
R
-
I
----
E
I
H
D
-
I
E
P
F
------------
S
R
L
V
-
R
-
G
-
R
V
A
---
L
L
G
D
A
G
H
S
T
T
P
D
I
G
Q
G
-
G
C
A
A
M
E
D
A
V
V
L
G
A
V
F
R
Q
--
T
R
-----
D
I
-
A
A
A
L
R
E
Y
E
A
Q
R
C
D
R
V
R
D
L
V
L
K
A
R
K
R
C
D
I
T
H
G
K
D
M
Q
L
T
E
-
A
W
Y
Q
E
L
R
E
-
E
T
G
-
E
R
I
I
N
G
M
C
D
T
I
-------
L
S
G
P
L
---------------------------------------------------------
16
PsiBlast_PDB
91.50
24%
-87
- C1 -
3RP6
1
HPXO_KLEP7
A:
[25-406]
--------
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
-----
G
-
I
-
D
C
-----
D
V
Y
E
A
V
K
--
E
I
-
K
-------------
A
--
A
I
S
V
W
-
P
N
G
V
K
C
M
A
H
L
G
M
G
D
I
M
E
T
F
G
G
P
L
-
R
-
R
M
A
Y
R
D
F
R
S
-------
G
E
-
N
--
M
T
---
Q
F
S
L
A
P
-
L
I
E
R
T
G
S
-
R
----
P
C
--
P
V
S
R
A
E
L
Q
R
E
M
L
D
Y
W
G
R
--
D
------------
S
---
V
Q
--
F
-
G
K
R
V
T
R
C
E
----------------------------------------------
E
D
A
D
G
--
V
T
V
W
F
T
----
D
------
G
----
S
---
S
A
--------------------------------------------
S
G
--
D
L
L
I
A
A
D
G
S
H
S
A
L
R
P
W
V
-
L
G
F
T
P
----
Q
R
-------------
R
-
Y
A
G
Y
V
N
--
W
--
N
G
L
V
E
I
D
E
A
-
L
A
--
P
----
G
-----
D
----
Q
-----------
W
T
T
F
V
G
E
G
--
K
-
R
-------
V
S
L
M
P
V
S
A
-----
G
R
------
F
Y
-------
F
F
F
--------------
D
---
V
------------
P
----
L
--
P
-----
A
G
-------------------
L
--
A
-
E
D
R
D
T
L
R
A
-----
D
---
L
S
R
Y
F
A
G
-
W
-
A
P
P
V
Q
K
-----
L
I
A
A
--------
L
D
P
Q
T
-
T
N
R
-
I
----
E
I
H
D
-
I
E
P
F
------------
S
R
L
V
-
R
-
G
-
R
V
A
---
L
L
G
D
A
G
H
S
T
T
P
D
I
G
Q
G
-
G
C
A
A
M
E
D
A
V
V
L
G
A
V
F
R
Q
--
T
R
-----
D
I
-
A
A
A
L
R
E
Y
E
A
Q
R
C
D
R
V
R
D
L
V
L
K
A
R
K
R
C
D
I
T
H
G
K
D
M
Q
L
T
E
-
A
W
Y
Q
E
L
R
E
-
E
T
G
-
E
R
I
I
N
G
M
C
D
T
I
-------
L
S
G
P
L
---------------------------------------------------------
110
Fugue
89.33
22%
-82
- C1 -
5FN0
2
KMO_PSEFL
A:
[6-460]
-----NA
R
Q
V
T
I
I
G
A
G
L
A
G
T
L
V
A
R
L
L
A
R
N
-----
G
-
W
-
Q
V
-----
N
L
F
E
R
R
P
--
D
P
-
R
I
----
E
T
GARGRS
I
--
N
L
A
L
A
-
E
R
G
A
H
A
L
R
L
A
G
L
E
R
E
V
L
A
E
A
V
M
M
-
R
-----------------
G
R
-
M
--
V
H
---
V
P
G
T
P
P
-
N
L
Q
P
Y
G
R
-
D
DS
E
V
I
W
--
S
I
N
R
D
R
L
N
R
I
L
L
D
G
A
-
E
--
A
------------
A
---
G
A
S
I
H
F
N
L
G
L
D
S
V
D
----------------------------------------------
F
A
R
Q
R
--
L
T
L
S
N
V
SG--
E
------
R
----
L
---
E
K
--------------------------------------------
R
F
--
H
L
L
I
G
A
D
G
C
N
S
A
V
R
Q
A
M
-
A
S
--
V
VDLG
E
H
-------------
L
-
E
T
Q
P
H
G
--
Y
--
K
E
L
Q
I
T
P
E
A
-
S
A
--
Q
----
F
-----
N
----
L
E
P
---------
N
A
L
H
I
W
P
H
--
G
-
D
-------
Y
M
C
I
A
L
P
N
-----
L
D
------
R
S
-------
F
T
V
-
T
L
F
------
L
H
H
-
Q
---
S
------------
P
----
A
--
A
-----
Q
P
-------------------
A
--
S
-
P
S
F
A
Q
L
-
V
-----
D
---------
G
-
H
-
A
A
--
R
R
-----
F
F
Q
R
QFPDLSPM
L
D
S
L
E
-
Q
D
F
-
E
H
H
P
T
G
K
L
A
-
T
L
R
L
------------
T
T
W
H
-
V
-
G
G
Q
A
V
---
L
L
G
D
A
A
H
P
M
V
P
F
H
G
Q
G
M
N
C
A
L
E
D
A
V
A
L
A
E
H
L
Q
S
A
--
A
------
D
N
-
A
S
A
L
A
A
F
T
A
----
Q
R
Q
P
D
A
----------
L
A
I
Q
A
M
A
L
E
N
Y
V
E
M
S
S
K
V
-
A
S
P
-
T
Y
L
L
E
R
E
L
G
Q
I
M
A
Q
R
Q
P
T
R
F
I
P
R
Y
S
M
V
T
F
S
RLP
Y
A
Q
A
M
A
R
G
Q
I
Q
E
Q
L
L
K
F
A
V
ANHSDLTSIN
L
D
A
V
E
H
E
V
T
R
C
L
PPLSHL
106
Fugue
88.80
21%
-75
- C1 -
4GF7
8
?
A:
[10-379]
-----KT
R
R
A
E
V
A
G
G
G
F
A
G
L
T
A
A
I
A
L
K
Q
N
-----
G
-
W
-
D
V
-----
R
L
H
E
K
S
S
--
E
L
-
R
A
----
F
G
------
A
--
G
I
Y
L
W
-
H
N
G
L
R
V
L
E
G
L
G
A
L
D
D
V
L
Q
G
S
H
T
P
-
P
T
Y
E
-----
T
W
M
H
--
N
-
K
S
V
-
S
--
K
E
---
T
F
N
---------
G
L
-
P
----
W
R
--
I
M
T
R
S
H
L
H
D
A
L
V
N
R
A
-
R
--
A
------------
L
---
G
V
D
I
S
-
V
N
S
E
A
V
A
A
----------------------------------------------
D
P
V
G
----
R
L
T
L
Q
----
T
------
G
----
E
---
V
L
--------------------------------------------
E
A
--
D
L
I
V
G
A
D
G
V
G
S
K
V
R
D
S
I
--
G
--
F
----
K
Q
-------------
D
-
R
W
V
S
K
D
--
G
--
L
I
R
L
I
V
P
R
M
-
K
K
--
E
LGHG
E
-----
W
----
D
N
T
---------
I
D
M
W
N
F
W
P
--
R
V
Q
-------
R
I
L
Y
S
P
C
N
-----
E
N
------
E
L
-------
Y
L
G
-
L
M
A
------
P
A
A
-
D
---
P
------------
R
----
G
--
S
-----
S
V
-------------------
P
--
I
-
D
-
L
E
V
W
-
V
-----
E
---
M
-----
F
-
P
-
F
L
--
E
P
-----
C
L
I
E
--------
A
A
K
L
K
-
T
A
R
-
Y
----
D
K
Y
E
-
T
T
K
L
------------
D
S
W
T
-
R
-
G
-
K
V
A
---
L
V
G
D
A
A
H
A
M
C
P
A
L
A
Q
G
A
G
C
A
M
V
N
A
F
S
L
S
Q
D
L
-
E
E
--
G
S
-----
S
V
-
E
D
A
L
V
A
W
E
T
----
R
I
R
P
I
T
----------
D
R
C
Q
A
L
S
G
D
Y
A
A
N
R
S
L
S
K
---
G
-
N
M
F
T
P
A
A
L
E
A
A
-------
R
Y
D
P
L
R
R
V
Y
S
W
P
--------
Q
-----------------------------------------
76
HHSearch
86.92
20%
-92
- C1 -
4BJZ
4
?
A:
[7-363]
-------
A
R
I
I
I
A
G
G
G
I
G
G
A
A
N
A
L
A
L
A
Q
K
-----
G
-
A
-
N
V
-----
T
L
F
E
R
A
S
--
E
F
-
G
E
----
V
G
------
A
--
G
L
Q
V
G
-
P
H
G
A
R
I
L
D
S
W
G
V
L
D
D
V
L
S
R
A
F
L
P
-
K
-
N
I
-----
V
F
R
D
--
A
I
T
A
E
-
V
--
L
T
---
K
I
D
L
G
S
E
F
R
G
R
Y
G
G
-
P
----
Y
F
--
V
T
H
R
S
D
L
H
A
T
L
V
D
A
A
-
R
A
-
A
------------
G
---
A
E
L
H
T
-
G
V
T
V
T
D
V
I
----------------------------------------------
T
E
G
D
K
--
A
I
V
S
T
D
----
D
------
G
----
R
---
T
H
--------------------------------------------
E
A
--
D
I
A
L
G
M
D
G
L
K
S
R
L
R
E
K
I
-
S
G
--
D
----
E
P
---------------
V
S
S
G
Y
A
--
A
--
Y
R
G
T
T
P
Y
R
D
V
E
L
--
D
----
E
-----
D
----
I
E
D
---------
V
V
G
Y
I
G
P
R
--
C
-
H
-------
F
I
Q
Y
P
L
R
G
-----
G
E
------
M
L
-------
N
Q
V
A
V
F
E
------
S
P
G
F
K
---
N
------------
G
----
I
EN
W
-----
G
G
-------------------
P
--
E
-
E
L
E
Q
A
Y
-
A
-----
H
---
C
-----
H
-
E
-
N
V
--
R
R
-----
G
I
D
Y
--------
L
W
----
K
D
R
-
W
----
W
P
M
Y
D
R
E
P
I
------------
E
N
W
V
-
D
-
G
-
R
M
I
---
L
L
G
D
A
A
H
P
P
L
Q
Y
L
A
S
G
A
V
M
A
I
E
D
A
K
C
L
A
D
Y
A
A
E
D
--
F
S
TGGNS
A
W
-
P
Q
I
L
K
E
V
N
T
----
E
R
A
P
R
C
----------
N
R
I
L
T
T
G
R
M
W
G
E
L
W
H
----------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.75
25%
-91
- C1 -
3RP8
2
HPXO_KLEP7
A:
[24-351]
-------
M
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
-----
G
-
I
-
D
C
-----
D
V
Y
E
A
V
K
--
E
I
---------------
A
--
A
I
S
V
W
-
P
N
G
V
K
C
M
A
H
L
G
M
G
D
I
M
E
T
F
G
G
P
L
-
R
-
R
M
A
Y
R
D
F
R
S
-------
G
E
-
N
--
M
T
---
Q
F
S
L
A
P
-
L
I
E
R
T
G
S
-
R
----
P
C
--
P
V
S
R
A
E
L
Q
R
E
M
L
D
Y
W
G
R
--
D
------------
S
---
V
Q
--
F
-
G
K
R
V
T
R
C
E
----------------------------------------------
E
D
A
D
G
--
V
T
V
W
F
T
----
D
------
G
----
S
---
S
A
--------------------------------------------
S
G
--
D
L
L
I
A
A
D
G
S
H
S
A
L
R
P
W
V
-
L
G
F
T
P
----
Q
R
-------------
R
-
Y
A
G
Y
V
N
--
W
--
N
G
L
V
E
I
D
E
A
-
L
A
--
P
----
G
-----
D
----
Q
-----------
W
T
T
F
V
G
E
G
--
K
-
Q
-------
V
S
L
M
P
V
S
A
-----
G
R
------
F
Y
-------
F
F
F
--------------
D
---
V
------------
P
----
L
--
P
-----
A
G
-------------------
L
--
A
-
E
D
R
D
T
L
R
A
-----
D
---
L
S
R
Y
F
A
G
-
W
-
A
P
P
V
Q
K
-----
L
I
A
A
--------
L
D
P
Q
T
-
T
N
R
-
I
----
E
I
H
D
-
I
E
P
F
------------
S
R
L
V
-
R
-
G
-
R
V
A
---
L
L
G
D
A
G
H
S
T
T
P
D
I
G
Q
G
-
G
C
A
A
M
E
D
A
V
V
L
G
A
V
F
R
Q
--
T
R
-----
D
I
-
A
A
A
L
R
E
Y
E
A
----
Q
----------------------------------------------------------------------------------------------------------------------
77
HHSearch
86.63
20%
-90
- C1 -
2X3N
1
?
A:
[7-360]
-------
I
D
V
L
I
N
G
C
G
I
G
G
A
M
L
A
Y
L
L
G
R
Q
-----
G
-
H
-
R
V
-----
V
V
V
E
Q
A
R
--
R
E
--------
N
------
G
--
A
D
L
L
K
-
P
A
G
I
R
V
V
E
A
A
G
L
L
A
E
V
T
R
R
G
G
R
V
R
H
-
E
L
-----
E
V
Y
---
H
-
D
G
E
-
L
--
L
R
---
Y
F
N
Y
S
S
-
V
--
D
A
R
G
-
Y
----
F
I
--
L
M
P
C
E
S
L
R
R
L
V
L
E
K
I
-
D
G
E
A
------------
T
---
V
E
M
L
F
-
E
T
R
I
E
A
V
Q
----------------------------------------------
R
D
E
R
H
AI
D
Q
V
R
L
N
----
D
------
G
----
R
---
V
L
--------------------------------------------
R
P
--
R
V
V
V
G
A
D
G
I
A
S
Y
V
R
R
R
L
-
L
D
--
I
----
D
V
E
------------
R
-
R
P
Y
P
S
P
--
M
--
L
V
G
T
F
A
L
A
--
P
C
--
V
----
A
-----
E
----
R
N
R
---------
L
-
Y
V
D
S
Q
G
--
G
-
L
-------
A
Y
F
Y
P
I
G
F
-----
D
R
------
A
R
-------
L
V
V
-
S
F
P
------
R
E
E
-
A
---
R
------------
E
L
M
--
A
--
D
-----
T
R
-------------------
G
--
E
-
S
L
R
R
R
L
-
Q
-----
R
---
F
-----
V
G
D
-
E
S
--
A
E
-----
A
I
A
A
--------
V
T
G
T
S
-
R
F
K
-
G
----
I
P
I
G
-
Y
L
N
L
------------
D
R
Y
W
-
A
-
D
-
N
V
A
---
M
L
G
D
A
I
H
N
V
H
P
I
T
G
Q
G
M
N
L
A
I
E
D
A
S
A
L
A
D
A
L
D
L
A
--
L
R
DAC--
A
L
-
E
D
A
L
A
G
Y
Q
A
----
E
R
F
P
V
N
----------
Q
A
I
V
S
Y
G
H
A
L
A
T
S
L
E
----------------------------------------------------------------------------------------
108
Fugue
85.51
21%
-74
- C1 -
4JY3
7
?
A:
[10-379]
-----K
T
R
R
A
E
V
A
G
G
G
F
A
G
L
T
A
A
I
A
L
K
Q
N
-----
G
-
W
-
D
V
-----
R
L
H
E
K
S
S
--
E
L
-
R
A
----
F
G
------
A
--
G
I
Y
L
W
-
H
N
G
L
R
V
L
E
G
L
G
A
L
D
D
V
L
Q
G
S
H
T
P
-
P
T
Y
E
-----
T
W
M
H
--
N
-
K
S
V
-
S
--
K
E
---
T
F
N
---------
G
L
-
P
----
W
R
--
I
M
T
R
S
H
L
H
D
A
L
V
N
R
A
-
R
--
A
------------
L
---
G
V
D
I
S
-
V
N
S
E
A
V
A
A
----------------------------------------------
D
P
V
G
----
R
L
T
L
Q
----
T
------
G
----
E
---
V
L
--------------------------------------------
E
A
--
D
L
I
V
G
A
D
G
V
G
S
K
V
R
D
S
I
G
F
K
--
Q
----
D
R
-------------
W
-
V
S
K
-----------
D
G
L
I
R
L
-
I
V
--
P
----
R
-----
M
----
K
K
E
LGHGEWDNT
I
D
M
W
N
F
W
P
--
R
-
V
-------
Q
R
I
L
Y
S
P
C
-----
N
E
------
N
E
-------
L
Y
L
-
G
L
M
------
A
P
A
-
A
---
D
------------
P
----
R
--
G
-----
S
S
-------------------
V
--
P
-
I
D
L
E
V
W
-
V
-----
E
---
M
-----
F
-
P
-
F
L
--
E
P
-----
C
L
I
E
--------
A
A
K
L
K
-
T
A
R
-
Y
----
D
K
Y
E
-
T
T
K
L
------------
D
S
W
T
-
R
-
G
-
K
V
A
---
L
V
G
D
A
A
H
A
M
C
P
A
L
A
Q
G
A
G
C
A
M
V
N
A
F
S
L
S
Q
D
L
-
E
E
--
G
S
-----
S
V
-
E
D
A
L
V
A
W
E
T
----
R
I
R
P
I
T
----------
D
R
C
Q
A
L
S
G
D
Y
A
A
N
R
S
L
S
K
---
G
-
N
M
F
T
P
A
A
L
E
A
A
-------
R
Y
D
P
L
R
R
V
Y
S
W
P
--------
Q
-----------------------------------------
19
PsiBlast_PDB
85.26
23%
-90
- C2 -
3V3O
4
?
A:
[8-355]
--------
N
V
A
I
I
G
G
G
P
V
G
L
T
M
A
K
L
L
Q
Q
N
-----
G
-
I
-
D
V
-----
S
V
Y
E
R
D
N
DR
E
A
-
R
I
----
F
G
------
G
--
T
L
D
L
H
K
G
S
G
Q
E
A
M
K
K
A
G
L
L
Q
T
Y
Y
D
L
A
L
P
M
---
G
V
-----
N
I
A
D
--
K
-
K
G
N
-
I
--
L
S
---
T
K
N
V
K
P
-
E
N
R
F
----
D
----
N
P
--
E
I
N
R
N
D
L
R
A
I
L
L
N
S
L
-
E
--
N
------------
D
---
T
-
V
I
W
-
D
R
K
L
V
M
L
E
----------------------------------------------
P
G
K
K
K
--
W
T
L
T
F
E
----
N
------
K
----
P
---
S
E
--------------------------------------------
T
A
--
D
L
V
I
L
A
N
G
G
M
S
K
V
R
K
F
V
-
T
D
--
T
----
E
V
-------------
E
-
E
T
G
T
F
N
--
I
--
Q
-----
A
D
I
-
H
Q
--
P
----
E
I----
N
----
C
P
G
---------
F
F
Q
L
C
N
G
N
--
R
-
L
-------
M
A
--
S
H
Q
G
-----
N
------------------
L
-
L
F
A
------
N
P
N
-
N
---
N
------------
G
A
L
H
F
G
--
I
-----
S
F
-------------------
K
TP
D
-
E
W
K
N
-------------
V
-----
D
-
F
-
Q
N
--
R
N
S
V
V
D
F
L
L
K
K
--------
F
S
D
W
D
-
E
R
Y
-
K
----
E
L
I
H
-
A
T
L
S
F
V
G
L
A
TRIFPLE
K
P
W
K
-
S
-
K
-
R
P
L
P
I
T
M
I
G
D
A
A
H
L
M
P
P
F
A
G
Q
G
V
N
S
G
L
V
D
A
L
I
L
S
D
N
L
A
D
G
--
K
F
-----
N
S
I
E
E
A
V
K
N
Y
E
Q
----
Q
M
--
F
I
----------
Y
G
K
E
A
Q
-------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
84.76
23%
-88
* C2 *
3V3N
5
?
A:
[8-355]
--------
N
V
A
I
I
G
G
G
P
V
G
L
T
M
A
K
L
L
Q
Q
N
-----
G
-
I
-
D
V
-----
S
V
Y
E
R
D
N
DR
E
A
-
R
I
----
F
G
------
G
--
T
L
D
L
H
K
G
S
G
Q
E
A
M
K
K
A
G
L
L
Q
T
Y
Y
D
L
A
L
P
M
---
G
V
-----
N
I
A
D
--
K
-
K
G
N
-
I
--
L
S
---
T
K
N
V
K
P
-
E
N
R
F
----
D
----
N
P
--
E
I
N
R
N
D
L
R
A
I
L
L
N
S
L
-
E
--
N
------------
D
---
T
-
V
I
W
-
D
R
K
L
V
M
L
E
----------------------------------------------
P
G
K
K
K
--
W
T
L
T
F
E
----
N
------
K
----
P
---
S
E
--------------------------------------------
T
A
--
D
L
V
I
L
A
N
G
G
M
S
K
V
R
K
F
V
-
T
D
--
T
----
E
V
-------------
E
-
E
T
G
T
F
N
--
I
--
Q
-----
A
D
I
-
H
Q
--
P
----
E
I----
N
----
C
P
G
---------
F
F
Q
L
C
N
G
N
--
R
-
L
-------
M
A
--
S
H
Q
G
-----
N
------------------
L
-
L
F
A
------
N
P
N
-
N
---
N
------------
G
A
L
H
F
G
--
I
-----
S
F
-------------------
K
TP
D
-
E
W
K
----
T
-----
Q
---
V
-----
D
-
F
-
Q
N
--
R
N
S
V
V
D
F
L
L
K
K
--------
F
S
D
W
D
-
E
R
Y
-
K
----
E
L
I
H
-
A
T
L
S
F
V
G
L
A
TRIFPLE
K
P
W
K
-
S
-
K
-
R
P
L
P
I
T
M
I
G
D
A
A
H
L
M
P
P
F
A
G
Q
G
V
N
S
G
L
V
D
A
L
I
L
S
D
N
L
A
D
G
--
K
F
-----
N
S
I
E
E
A
V
K
N
Y
E
Q
----
Q
M
--
F
I
----------
Y
G
K
E
A
Q
-------------------------------------------------------------------------------------------------
107
Fugue
84.57
20%
-75
- C1 -
4H2Q
7
?
A:
[10-379]
-----K
T
R
R
A
E
V
A
G
G
G
F
A
G
L
T
A
A
I
A
L
K
Q
N
-----
G
-
W
-
D
V
-----
R
L
H
E
K
S
S
--
E
L
-
R
A
----
F
G
------
A
--
G
I
Y
L
W
-
H
N
G
L
R
V
L
E
G
L
G
A
L
D
D
V
L
Q
G
S
H
T
P
-
P
T
Y
E
-----
T
W
M
H
--
N
-
K
S
V
-
S
--
K
E
---
T
F
N
---------
G
L
-
P
----
W
R
--
I
M
T
R
S
H
L
H
D
A
L
V
N
R
A
-
R
--
A
------------
L
---
G
V
D
I
S
-
V
N
S
E
A
V
A
A
----------------------------------------------
D
P
V
G
----
R
L
T
L
Q
----
T
------
G
----
E
---
V
L
--------------------------------------------
E
A
--
D
L
I
V
G
A
D
G
V
G
S
K
V
R
D
S
I
--
G
--
F
----
K
Q
-------------
D
-
R
W
V
S
K
D
--
G
--
L
I
R
L
I
V
P
R
M
-
K
K
--
E
----
L
-----
G
HGEW
D
N
T
---------
I
D
M
W
N
F
W
P
--
R
-
V
-------
Q
R
I
L
Y
S
P
C
-----
N
E
------
N
E
-------
L
Y
L
-
G
L
M
------
A
P
A
-
A
---
D
------------
P
----
R
--
G
-----
S
S
-------------------
V
--
P
-
I
D
L
E
V
W
-
V
-----
E
---
M
-----
F
-
P
-
F
L
--
E
P
-----
C
L
I
E
--------
A
A
K
L
K
-
T
A
R
-
Y
----
D
K
Y
E
-
T
T
K
L
------------
D
S
W
T
-
R
-
G
-
K
V
A
---
L
V
G
D
A
A
H
A
M
C
P
A
L
A
Q
G
A
G
C
A
M
V
N
A
F
S
L
S
Q
D
L
-
E
E
--
G
S
-----
S
V
-
E
D
A
L
V
A
W
E
T
----
R
I
R
P
I
T
----------
D
R
C
Q
A
L
S
G
D
Y
A
A
N
R
S
L
S
K
---
G
-
N
M
F
T
P
A
A
L
E
A
A
-------
R
Y
D
P
L
R
R
V
Y
S
W
P
--------
Q
-----------------------------------------
81
HHSearch
84.53
20%
-91
- C1 -
3C96
1
?
A:
[5-388]
-------
I
D
I
L
I
A
G
A
G
I
G
G
L
S
C
A
L
A
L
H
Q
A
-----
G
-
I
G
K
V
-----
T
L
L
E
S
S
S
--
E
I
-
R
P
----
L
G
------
V
--
G
I
N
I
Q
-
P
A
A
V
E
A
L
A
E
L
G
L
G
P
A
L
A
A
T
A
I
P
T
-
H
-
E
L
-----
R
Y
I
D
--
Q
-
S
G
A
-
T
--
V
W
---
S
E
P
R
G
--
V
E
A
G
N
A
Y
-
P
----
Q
Y
--
S
I
H
R
G
E
L
Q
M
I
L
L
A
A
V
-
R
--
E
R
LG---------
Q
---
Q
A
V
R
T
-
G
L
G
V
E
R
I
E
----------------------------------------------
E
R
D
G
R
--
V
L
I
G
A
R
----
D
------
G
HG
K
P
Q
---
A
L
--------------------------------------------
G
A
--
D
V
L
V
G
A
D
G
I
H
S
A
V
R
A
H
L
-
H
P
--
D
----
Q
R
-------------
P
--
L
S
H
G
G
I
T
M
--
W
R
G
V
T
E
F
D
--
R
--------
F
-----
L
----
D
G
K
---------
T
M
I
V
A
N
D
E
HW
S
-
R
-------
L
V
A
Y
P
I
S
A
R
H
A
A
E
G
K
SL----
V
N
-------
W
V
C
-
M
V
P
------
S
A
A
-
V
GQL
D
------------
N
----
E
--
A
DWN
R
D
G
R
-------------------
L
--
E
-
D
V
L
P
F
F
-
A
-----
D
---
W
-----
D
-
L
-
G
W
--
F
D
-----
I
R
D
L
--------
L
T
R
N
Q
-
L
I
L
-
Q
----
Y
P
M
V
D
R
D
P
L
------------
P
H
W
G
-
R
-
G
-
R
I
T
---
L
L
G
D
A
A
H
L
M
Y
P
M
G
A
N
G
A
S
Q
A
I
L
D
G
I
E
L
A
A
A
L
A
R
N
--
A
------
D
V
-
A
A
A
L
R
E
Y
E
E
----
A
R
R
P
T
A
----------
N
K
I
I
L
A
N
R
E
R
E
--------------------------------------------------------------------------------------------
102
Fugue
84.47
17%
-84
- C1 -
1FOH
2
PH2M_TRICU
A:
[1-461]
T
K
Y
S
E
S
Y
C
D
V
L
I
V
G
A
G
P
A
G
L
M
A
A
R
V
L
S
E
Y
-----
V
-
R
-
Q
K
PD
L
K
V
R
I
I
D
K
R
S
--
T
---
K
VY--
N
G
------
Q
--
A
D
G
L
Q
-
C
R
T
L
E
S
L
K
N
L
G
L
A
D
K
I
L
S
E
A
N
D
M
-
S
-
T
I
-----
A
L
Y
N
P
D
E
-
N
G
H
-
I
--
R
R
---
T
D
R
I
P
D
-
T
L
P
G
I
S
R
Y
H
----
Q
V
--
V
L
H
Q
G
R
I
E
R
H
I
L
D
S
I
-
A
--
E
I
S
D
TR
I
K
V
E
R
PL
I
---
P
E
K
M
E
-
I
D
S
S
K
A
E
D
----------------------------------------------
P
E
A
Y
P
--
V
T
M
T
L
R
----
Y
------
M
----
S
---
D
H
E
S
T
P
L
QF
G
H
K
T
E
NSLFHS
N
L
Q
T
Q
E
E
E
D
A
N
Y
R
L
PEGKEAG
E
I
E
T
V
H
C
--
K
Y
V
I
G
C
D
G
G
H
S
W
V
R
R
T
L
----------
G
F
-------------
E
-
M
I
G
E
Q
T
--
D
--
Y
I
W
G
V
L
D
A
V
-
P
A
--
S
NF--
P
-----
D
----
I
R
S
---------
R
C
A
I
H
S
A
E
--
S
-
G
-------
S
I
M
I
I
P
R
E
-----
N
N
------
L
V
-------
R
F
Y
-
V
Q
L
------
Q
----------------------------------
F
T
-------------------
P
--
E
-
V
V
I
A
N
A
-
K
-----
K
---
I
-----
F
-
H
-
P
Y
----------
T
F
D
--------
V
Q
Q
L
D
-
W
F
T
-
A
----
Y
H
I
G
-
Q
R
V
T
------------
E
K
F
S
-
K
D
E
-
R
V
F
---
I
A
G
D
A
C
H
T
H
S
P
K
A
G
Q
G
M
N
T
S
M
M
D
T
Y
N
L
G
W
K
L
G
L
V
L
T
G
R
-----
A
K
-
R
D
I
L
K
T
Y
E
E
----
E
R
H
A
F
A
----------
Q
A
L
I
D
F
D
H
Q
F
S
R
L
F
S
G
R
P
-
A
K
D
-
V
--
A
D
E
M
G
V
S
M
-------
D
V
F
K
---
E
A
F
V
K
--------
G
N
E
F
A
S
G
T
A
I
N
Y
D
E----------------------------
101
Fugue
84.11
19%
-85
- C1 -
3C96
1
?
A:
[4-403]
------P
I
D
I
L
I
A
G
A
G
I
G
G
L
S
C
A
L
A
L
H
Q
A
-----
G
I
G
-
K
V
-----
T
L
L
E
S
S
S
--
E
I
-
R
P
----
L
G
------
V
--
G
I
N
I
Q
-
P
A
A
V
E
A
L
A
E
L
G
L
G
P
A
L
A
A
T
A
I
P
T
-
H
-
E
L
-----
R
Y
I
D
--
Q
-
S
G
A
-
T
--
V
W
---
S
E
P
R
G
V
-
E
A
G
N
-
A
Y
-
P
----
Q
Y
--
S
I
H
R
G
E
L
Q
M
I
L
L
A
A
V
-
R
--
E
------------
R
LGQ
Q
A
V
R
T
-
G
L
G
V
E
R
I
E
----------------------------------------------
E
R
D
G
R
--
V
L
I
G
A
R
D
GHG
K
------
P
----
Q
---
A
L
--------------------------------------------
G
A
--
D
V
L
V
G
A
D
G
I
H
S
A
V
R
A
H
L
-
H
P
--
D
----
Q
R
-------------
P
-
L
S
H
G
G
I
--
T
--
M
W
R
G
V
T
E
F
D
-
R
F
--
L
----
D
-----
G
----
K
T
M
---------
I
V
A
N
D
E
H
W
--
S
-
R
-------
L
V
A
Y
P
I
S
A
-----
R
H
------
A
A
E
GKSL
V
N
W
V
C
-
M
V
P
------
S
A
A
-
V
---
G
QLDNEADW----
N
----
R
--
D
-----
G
R
-------------------
L
--
E
-
D
V
L
P
F
F
-
A
-----
D
---
W
-----
D
-
L
-
G
W
--
F
D
-----
I
R
D
L
--------
L
T
R
N
Q
-
L
I
L
Q
Y
----
P
M
V
D
-
R
D
P
L
------------
P
H
W
G
-
R
-
G
-
R
I
T
---
L
L
G
D
A
A
H
L
M
Y
P
M
G
A
N
G
A
S
Q
A
I
L
D
G
I
E
L
A
A
A
L
A
R
N
--
A
------
D
V
-
A
A
A
L
R
E
Y
E
E
----
A
R
R
P
T
A
----------
N
K
I
I
L
A
N
R
E
R
E
K
E
E
W
A
A
A
-
S
R
P
-
E
R
P
R
L
---------------------------------------------------------------------------
14
PsiBlast_PDB
83.94
21%
-71
- C1 -
3GMB
1
?
A:
[49-412]
--------
R
A
E
V
A
G
G
G
F
A
G
L
T
A
A
I
A
L
K
Q
N
-----
G
-
W
-
D
V
-----
R
L
H
E
K
S
S
--
E
L
-
R
A
----
F
G
------
A
--
G
I
Y
L
W
-
H
N
G
L
R
V
L
E
G
L
G
A
L
D
D
V
L
Q
G
S
H
T
P
-
P
-
T
Y
-----
E
T
W
M
--
H
-
N
K
S
-
V
--
S
K
---
E
T
F
N
G
L
-
P
W
R
I
M
T
R
-
S
----
H
L
--
H
D
A
L
V
N
R
A
R
A
L
G
V
D
I
-
S
--
V
------------
N
---
S
E
A
V
A
-
A
D
P
V
G
---------------------------------------------------------
R
L
T
L
Q
----
T
------
G
----
E
---
V
L
--------------------------------------------
E
A
--
D
L
I
V
G
A
D
G
V
G
S
K
V
R
D
S
I
G
F
K
--
Q
----
D
R
W
V
S
K
D
G
L
I
R
L
I
V
P
R
-
M
K
K
E
L
G
--
H
--
G
E
W
D
N
T
I
D
M
-
W
N
FW
P
----
R
-----
V
----
Q
R
-----------
I
L
Y
S
P
C
N
-------------------------
E
N
------
E
L
-------
Y
L
G
-
L
M
A
------
P
A
A
-
D
---
P
------------
R
----
G
--
S
-----
S
V
-------------------
P
--
I
-
D
L
E
V
W
V
-
E
-----
M
---
F
-----
P
-
F
-
L
E
--
P
C
-----
L
I
E
A
--------
A
K
-
L
K
-
T
A
R
-
Y
----
D
K
Y
E
-
T
T
K
L
------------
D
S
W
T
-
R
-
G
-
K
V
A
---
L
V
G
D
A
A
H
A
M
C
P
A
L
A
Q
G
A
G
C
A
M
V
N
A
F
S
L
S
Q
D
L
-
E
E
--
G
S
-----
S
V
-
E
D
A
L
V
A
W
E
T
----
R
I
R
P
I
T
----------
D
R
C
Q
A
L
S
G
D
Y
A
---
A
N
R
S
L
S
K
G
-
N
M
F
T
P
A
A
L
E
A
A
-------
R
Y
D
P
L
R
R
V
Y
S
----------------------------------------------------
88
HHSearch
83.44
21%
-92
- C1 -
5FN0
2
KMO_PSEFL
A:
[8-369]
-------
R
Q
V
T
I
I
G
A
G
L
A
G
T
L
V
A
R
L
L
A
R
N
-----
G
-
W
-
Q
V
-----
N
L
F
E
R
R
P
--
D
P
-
R
I
ETGA
R
G
------
R
SI
N
L
A
L
A
-
E
R
G
A
H
A
L
R
L
A
G
L
E
R
E
V
L
A
E
A
V
M
M
-
R
-
G
R
-----
M
V
H
V
--
P
-
G
T
--
P
--
P
N
---
L
Q
P
Y
G
----
R
D
D
S
E
-
V
----
I
W
--
S
I
N
R
D
R
L
N
R
I
L
L
D
G
A
-
E
A
-
A
------------
G
---
A
S
I
H
F
-
N
L
G
L
D
S
V
D
----------------------------------------------
F
A
R
Q
R
--
L
T
L
S
N
V
----
S
------
G
----
E
R
L
-
E
K
--------------------------------------------
R
F
--
H
L
L
I
G
A
D
G
C
N
S
A
V
R
Q
A
M
-
A
S
--
V
----
V
D
L------------
G
E
H
L
E
T
Q
P
--
H
--
G
Y
K
E
L
Q
I
T
P
-
E
A
--
S
----
A
Q
F
NL-
E
----
P
N
A
---------
L
H
I
W
P
H
G
D
--
Y
-
M
-------
C
I
A
L
P
N
L
D
-----
R
S
------
F
T
-------
V
T
L
-
F
L
H
------
H
Q
S
-
P
---
A
AQPASPSFAQLV
D
----
G
--
H
-----
A
A
-------------------
R
--
R
-
F
F
Q
R
Q
F
-
P
-----
D
--------------
L
--
S
P
-----
M
L
D
S
--------
L
E
Q
D
F
E
H
H
P
-
T
----
G
K
L
A
-
T
L
R
L
------------
T
T
W
H
V
G
-
G
-
Q
A
V
---
L
L
G
D
A
A
H
P
M
V
P
F
H
G
Q
G
M
N
C
A
L
E
D
A
V
A
L
A
E
H
L
Q
S
A
--
A
------
D
N
-
A
S
A
L
A
A
F
T
A
----
Q
R
Q
P
D
A
----------
L
A
I
Q
A
M
A
L
E
N
---------------------------------------------------------------------------------------------
85
HHSearch
83.13
17%
-83
- C1 -
1PN0
3
PH2M_TRICU
A:
[9-424]
-------
C
D
V
L
I
V
G
A
G
P
A
G
L
M
A
A
R
V
L
S
E
Y
V
R
Q
KP
D
-
L
-
K
V
-----
R
I
I
D
K
R
S
--
T
K
-
V
Y
----
N
G
------
Q
--
A
D
G
L
Q
-
C
R
T
L
E
S
L
K
N
L
G
L
A
D
K
I
L
S
E
A
N
D
M
-
S
-
T
I
-----
A
L
Y
N
--
P
-
D
E
N
G
H
--
I
R
R
T
D
R
I
P
D
T
--
L
P
G
I
S
R
Y
-
H
----
Q
V
--
V
L
H
Q
G
R
I
E
R
R
I
L
D
S
I
-
A
E
-
I
S
D
T---------
R
---
I
K
V
E
R
-
P
L
I
P
E
K
M
E
I
DSSKAEDPEAYP
V
T
M
T
L
R
Y
M
S
EDESTPLQF
G
H
K
T
E
N
G
LFRS
N
L
Q
T
Q
E
E
E
D
--
A
N
Y
R
L
P
----
E
GKEAG
E
I
----
E
---
T
V
--------------------------------------------
H
C
--
K
Y
V
I
G
C
D
G
G
H
S
W
V
R
R
T
L
-
G
F
--
E
----
M
I
-------------
G
-
E
Q
T
D
Y
I
--
W
--
G
V
L
D
A
V
P
A
S
-
N
F
--
P
----
D
-----
I
----
R
S
R
---------
C
A
I
H
S
A
E
S
--
G
-
S
-------
I
M
I
I
P
R
E
N
-----
N
L
------
V
R
-------
F
Y
V
-
Q
L
Q
------
A
---------------------TKFT
P
--
E
-----
V
V
-------------------
I
--
A
-
N
A
K
K
I
F
-
H
-----
P
---
Y
-----
T
-
F
------
D
-----
V
-
Q
Q
--------
L
---
D
-
W
F
T
-
A
----
Y
H
I
G
-
Q
R
V
T
------------
E
K
F
S
-
K
D
E
-
R
V
F
---
I
A
G
D
A
C
H
T
H
S
P
K
A
G
Q
G
M
N
T
S
M
M
D
T
Y
N
L
G
W
K
L
G
L
V
--
L
T
GR---
A
K
-
R
D
I
L
K
T
Y
E
E
----
E
R
Q
P
F
A
----------
Q
A
L
I
D
F
D
H
Q
F
S
R
L
F
S
----------------------------------------------------------------------------------------
75
HHSearch
83.13
21%
-86
- C1 -
3RP8
2
HPXO_KLEP7
A:
[24-370]
-------
M
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
-----
G
-
I
-
D
C
-----
D
V
Y
E
A
V
K
--
E
I
---------------
A
--
A
I
S
V
W
-
P
N
G
V
K
C
M
A
H
L
G
M
G
D
I
M
E
T
F
G
G
P
L
-
R
-
R
M
-----
A
Y
R
D
--
F
R
S
G
E
-
N
--
M
T
---
Q
F
S
L
A
P
-
L
I
E
R
T
G
S
-
R
----
P
C
--
P
V
S
R
A
E
L
Q
R
E
M
L
D
Y
W
-
G
---------------
R
---
D
S
V
Q
F
-
G
K
R
V
T
R
C
E
----------------------------------------------
E
D
A
D
G
--
V
T
V
W
F
T
----
D
------
G
----
S
---
S
A
--------------------------------------------
S
G
--
D
L
L
I
A
A
D
G
S
H
S
A
L
R
P
W
V
-
L
G
--
F
----
T
P
---------------
Q
R
R
Y
A
G
--
Y
V
N
W
N
G
L
V
E
I
D
--
E
A
--
L
----
A
-----
P
----
G
D
Q
---------
W
T
T
F
V
G
E
G
--
K
-
Q
-------
V
S
L
M
P
V
S
A
-----
G
R
------
F
Y
-------
F
F
F
-
D
V
P
------
L
P
A
G
L
A--
E
------------
D
----
R
--
D
-----
T
L
-------------------
R
--
A
-
D
L
S
R
Y
F
-
A
-----
G
---
W
-----
A
-
P
-
P
V
--
Q
K
-----
L
I
A
A
--------
L
D
P
Q
--
T
T
N
-
R
----
I
E
I
H
D
I
E
P
F
------------
S
R
L
V
-
R
-
G
-
R
V
A
---
L
L
G
D
A
G
H
S
T
T
P
D
I
G
Q
G
G
C
A
A
M
E
D
A
V
V
L
G
A
V
F
R
Q
T
--
R
------
D
I
-
A
A
A
L
R
E
Y
E
A
----
Q
R
C
D
R
V
----------
R
D
L
V
L
K
A
R
K
R
C
D
I
T
-----------------------------------------------------------------------------------------
94
HHSearch
82.43
20%
-91
- C1 -
2VOU
3
DHPH_ARTNI
A:
[6-365]
-------
D
R
I
A
V
V
G
G
S
I
S
G
L
T
A
A
L
M
L
R
D
A
-----
G
-
V
-
D
V
-----
D
V
Y
E
R
S
P
--
Q
P
L
S
G
----
F
G
------
T
--
G
I
V
V
Q
-
P
E
L
V
H
Y
L
L
E
Q
G
V
E
L
D
--
S
I
S
V
P
S
-
S
-
S
M
-----
E
Y
V
D
--
A
L
T
G
E
-
R
--
V
G
---
S
V
P
A
-----------
D
----
W
R
--
F
T
S
Y
D
S
I
Y
G
G
L
Y
E
L
F
----
G
------------
P
---
E
R
Y
H
T
-
S
K
C
L
V
G
L
S
----------------------------------------------
Q
D
S
E
T
--
V
Q
M
R
F
S
----
D
------
G
----
T
---
K
A
--------------------------------------------
E
A
--
N
W
V
I
G
A
D
G
G
A
S
V
V
R
K
R
L
-
L
G
--
I
----
E
P
-----------------
T
Y
A
G
--
Y
--
V
T
W
R
G
V
L
Q
P
-
G
E
--
V
A---
D
D
V
W
N
Y
F
----
N
D
K
---------
F
T
Y
G
L
L
D
D
--
G
-
H
-------
L
I
A
Y
P
I
P
G
-----
R
E
NA
E
S
P
R
L
N
-------
F
Q
W
-
Y
W
N
------
V
A
E
-
G
---
P
------------
D
----
L
--
D
-----
E
L
M
TDVRGIRLPTSVHNNSLN
P
--
H
-
N
L
R
Q
F
H
-
S
-----
K
G
E
S
L
-----
F
-
K
-
P
F
--
R
D
-----
L
V
L
----------
N
A
S
S
-
P
-
F
-
V
----
T
V
V
A
-
D
A
T
V
------------
D
R
M
V
-
H
-
G
-
R
V
L
---
L
I
G
D
A
A
V
T
P
R
P
H
A
A
A
G
G
A
K
A
S
D
D
A
R
T
L
A
E
V
F
T
K
N
---
H
-----
D
L
-
R
G
S
L
Q
S
W
E
T
----
R
Q
L
Q
Q
G
----------
H
A
Y
L
N
K
V
K
K
M
A
--------------------------------------------------------------------------------------------