@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0585c: (2016-04-23 )
MRVDGRDIGVSGNLLQPLTRRTNDIIRAVLAAIYLVAVITSSLITRPQWVALEKSISEIVGVLSPSQSDLVYLGYGLAILALPFVILIGLIVSRQWKLLGAYAAAGLMAVLPLSISSSRIAAPRWHFDLSDRLATLLAQFLDDPRWIAMLAAVLTVSGPWLPARWRHWWWALLLAFVPIHLVVSAIVPARSLLGLAVGWLVGALVVLVVGTPALEVPLDGAIRALAKRGFAVSGLAVVRPAGPGPLVLSAACEQPNAGACSEALIELYGPHQSGGGALRQLWLKLTLRGTETAPLQASMRRAVEHRALMAIAFGDLGMANTTVIAVSPLDRGWTLYAHRPARGIGISECTKTTPTAHVWEALRTLHDQQISHGDLCSAEITVDNGAVLFGGFGEAEYGATDAQLQSDLAQLLVTTSALYDAEAAVTAAIDTFGKQAILAASRRLTKSAVPKRIRESITDPNAVIASTRAEVMRQTGADQIKAETITRFSRGQLIQLVLIGALVYVAYPFISTVPTFFSQLRTANWWWALLGLAVSALTYVGAAAALWACADGLVGFWKLSIMQVANTFAATTTPAGVGGLALSTRFLQKGGLTAVRATAAVALQQSVQVIVHLVLLILFSALAGTSTDLSHFVPNATVLYLIAGVALGIVGTFLFVPKLRRWLATAVRPKLREVTNDLIALAREPKRLALIVLGCAGTTLGAALALWASIEAFGGGTTFVTVTVVTMVGGTLASAAPTPGGVGAVEAALIGGLAAFGVPAALGVPSVLLYRLLTCWLPVFAGWQVMHWLTRHEMI
Atome Classification :
(20 SA)
.........10........20.-.......30........--40........50........60--------........70........80........90........100.......110....------------...120.......130.......140.......150.......160.......170.......180.......190.---....--..200.......210.......220......---------.230.....--------..240..-.....250.......260------...-----......270---...--------....280.......290....-...300-........310....-----...-320.......330----........340..--.....350----------------.........360...----------..----..370.......380.------.----.----....390.........400.-......410......--.420.--.-----------.-----....430..-.....440.......450.......460.......470.......480.......490...-....500.......510.......520.......530.......540---........550.......560.......570.......580......-----.590.......600.......610.......620.......630.......640.......650......-.660.......670.......680.......690.......700----.......710.......720.......730.......740.......750.......760.......770.......780.......790...----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRVDGRDIGVSG
N
L
L
Q
P
L
T
R
R
T
-
N
D
I
I
R
A
V
L
A
A
I
Y
L
V
A
V
I
--
T
S
S
L
ITRP
Q
W
V
A
L
E
K
S
I
S
E
I
V
G
--------VLSPSQS
D
L
V
Y
L
G
Y
G
L
A
I
L
A
L
P
F
V
I
L
I
G
L
I
V
S
R
Q
W
K
L
L
G
A
Y
A
A
A
G
L
M
A
VLPLSIS------------SSRIAA
P
R
W
HF
D
L
S
D
R
L
A
T
L
L
A
Q
F
LDD
P
R
W
I
A
M
L
A
A
V
L
TVSGPWLP
A
R
W
R
H
W
W
W
A
L
L
L
A
F
V
P
I
H
L
V
V
S
A
I
V
P
A
R
S
L
L
---
G
L
A
V
--
G
W
L
V
G
A
L
V
V
L
V
VGTPALEVPL
D
G
A
I
R
A
L
A
KR---------GFAVS
G
L
A
V
--------
V
RPAGPG-
P
L
V
L
S
AACEQPNAG
A
C
--------
S
E
A
-----
L
I
E
L
YGPHQ---SG
G
--------
G
A
L
R
Q
L
W
L
K
L
T
LRGTETA
P
L
Q
-
A
S
M
R
R
--
A
V
E
H
R
A
L
M
A
I
A
FGDL-----GMA-
N
T
T
V
I
A
V
SPLDR-----
G
W
T
L
Y
A
HRPARGI--
G
I
S
E
CT------------------KTT
P
T
A
H
V
W
E
A
L
R
T
L
----------
H
D
----QQISHGDLC
S
A
E
I
T
VD------N----
G
----
A
V
L
F
G--GFGEAEYGA
T
D
A
Q
-
L
Q
S
D
L
A
Q
L
L
V
T
T
S
A
L--YD
A
E
A
--
A
-----------
V
-----
T
A
A
I
D
T
F
G
K
-
Q
A
I
L
A
A
S
R
R
L
T
K
S
A
V
P
K
R
I
R
E
SITDP
N
A
V
I
A
S
T
R
A
E
V
M
R
QTGA
D
Q
I
K
A
E
T
I
TRFSRGQ
L
I
Q
-
L
V
L
I
G
A
L
V
Y
V
A
Y
P
F
I
S
T
V
P
T
F
F
S
QLRTA
N
W
W
W
A
L
L
G
L
A
V
S
A
L
T
Y
V
G
----
A
A
A
A
L
W
A
C
A
D
G
L
V
G
F
W
K
L
S
I
M
Q
V
A
N
T
FAATTTPAGVG
G
L
A
L
S
T
R
F
L
Q-----KGG
L
T
A
V
R
A
T
A
A
V
A
L
Q
Q
S
V
Q
V
I
V
H
L
V
L
L
I
L
F
S
A
LAGTS
T
D
L
S
H
FVPN
A
T
V
L
Y
L
I
A
G
V
A
L
G
I
V
G
T
F
L
F
V
P
K
-
L
R
R
W
L
A
T
AV
R
P
K
L
R
E
V
T
N
D
L
I
A
L
AREP
K
R
L
A
L
I
V
L
GCAG
T
T
L
G
A
----
A
L
A
L
W
A
S
I
E
AFGGG
T
T
F
V
T
V
T
V
V
T
MVGGTLASAAPTPG
G
V
G
A
V
E
A
A
L
I
G
G
L
A
A
FGV
P
A
AL
G
V
P
S
V
L
L
Y
R
L
L
T
C
W
L
P
V
F
A
G
W
Q
V
M
H
W
L
T
R
HEMI----
40
Fugue
82.15
16%
-104
- C1 -
4ZM6
2
?
A:
[8-858]
----
N
L
D
K
E
I
G
Q
L
L
M
C
G
F
D
G
L
E
P
T
P
G
I
I
D
L
I
E
N
H
N
L
G
S
I
I
L
F
S
R
N
I
A
T
P
K
Q
V
Q
K
L
T
H
S
L
Q
Q
I
A
R
N
A
GHK
R
P
L
F
I
A
V
D
Q
E
N
G
V
V
R
R
L
G
D
S
G
T
Y
L
P
G
N
M
A
L
G
A
L
G
S
S
T
A
A
R
N
V
A
M
A
I
S
K
E
L
L
T
L
G
M
N
W
N
LAPVLDVNNNPL
N
P
V
I
G
V
R
S
Y
G
Q
D
P
E
L
V
A
R
M
G
L
A
Q
V
E
G
Y
Q
R
G
-
K
V
A
T
S
I
K
H
F
P
G
H
G
D
T
A
T
D
S
H
L
D
-
V
P
V
I
N
K
T
L
E
E
L
D
K
T
E
L
V
P
F
K
K
A
L
E
AG
G
I
A
C
PT
S
V
M
V
G
H
M
L
L
P
H
F
N
K
D
V
V
S
S
I
A
P
E
I
V
R
D
L
L
R
R
---------
R
F
G
Y
K
G
V
I
I
T
D
CLEMDA
V
K
E
T
V
G
T
-
P
K
G
A
L
M
A
L
Q
A
G
N
D
M
A
M
I
S
H
TL
A
F
Q
K
D
A
-----
F
K
V
L
Y
S
A
L
Q
---
E
G
Q
LD
K
D
E
I
R
Q
S
L
Q
R
V
A
Q
L
K
D
Q
F
L
N
W
D
D
V
L
Q
Q
-
A
D
L
K
T
MG
S
E
A
H
A
T
L
S
K
E
L
Y
D
R
V
PTVVT
N
R
K
-
N
T
L
P
I
R
P
A
Q
T
D
K
-----
I
L
F
L
A
A
H
V
P
E
K
------------------------------
E
P
F
N
S
F
H
A
S
L
L
K
R
----------
H
T
N
L
E
Y
I
I
Y
N
E
E
T
P
D
L
S
Q
K
I
Q
E
------
A
----
D
----
W
V
I
I
G
T
A
N
A
N
L
Y
P
F
Q
V
R
M
V
Q
-
Q
A
Q
K
L
A
K
R
L
V
V
A
A
V
M
NP
Y
D
Q
M
C
FP
Q
-----------
V
-----
D
T
Y
L
V
T
Y
E
Y
T
P
P
A
H
E
A
A
V
R
L
I
F
G
E
I
E
T
R
S
R
L
P
I
S
I
P
N
V
D
D
A
I
A
P
A
T
F
I
V
D
D
Y
R
N
D
D
D
L
D
H
V
T
A
M
W
D
D
I
F
G
K
D
W
P
L
R
K
D
K
I
N
L
G
L
Q
R
A
K
L
Q
K
H
K
V
A
R
D
S
Q
G
K
----
I
V
G
F
V
A
T
Q
I
V
V
V
D
N
K
K
H
G
Q
L
M
L
L
M
V
S
P
S
Y
Q
G
--
K
G
V
G
T
L
L
H
D
A
A
L
E
H
F
R
E
Q
G
A
D
C
I
K
L
G
S
T
Y
P
R
FFPGV
P
D
D
D
A
Q
S
R
K
A
Q
A
F
F
S
K
K
G
W
R
M
D
D
N
L
V
H
D
L
I
G
D
L
Q
D
Y
K
V
P
D
K
I
Q
A
R
M
L
K
E
K
I
W
F
G
R
I
K
P
S
E
T
W
E
L
Y
A
F
Q
Q
R
N
F
P
H
W
L
S
T
Y
Q
H
H
V
E
L
G
D
Y
Q
D
L
I
V
A
R
Q
D
D
E
N
G
R
V
I
A
S
L
I
L
N
T
T
H
V
S
HEYR
S
D
L
I
W
T
D
D
K
L
F
G
E
R
S
G
G
M
A
C
V
G
V
----------
A
Q
E
E
R
G
R
G
I
G
I
G
I
V
A
H
A
N
W
L
L
K
Q
R
---
G
V
T
K
S
Y
V
D
-----
W
V
E
L
L
D
F
Y
S
R
V
G
Y
K
T
W
R
S
Y
R
L
G
H
F
15
HHSearch
51.35
13%
-29
- C3 -
4AW2
3
MRCKA_RAT
A:
[88-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
V
A
V
V
K
L
K
----
N
A
D
--------
K
V
F
-----
A
M
K
I
L
N
K
W
E
---
M
L
K
------------------------------
R
A
E
T
A
--
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
-------
W
-
I
T
T
L
H
Y
A
F
Q
D
D
N
-----
N
L
Y
L
V
M
D
Y
Y
-
V
G
G
--
D
L
L
T
L
L
S
K
F
EDRLP
E
E
M
-------
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
----------
H
Q
----
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
------
M
N---
G
----
H
I
R
L
A
--
D
F
G
S
C
L
K
L
M
E
D
G
T
----
V
Q
S
S
V
A
V
G
T
P
D
Y
--
I
S
P
E
I
--
L
Q
A
M
E
GGKGR--
Y
-----
G
P
E
C
D
W
W
S
L
-
G
V
C
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
50.63
12%
-33
- C3 -
4YHJ
1
GRK4_HUMAN
A:
[199-376]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
V
C
A
C
Q
V
R
----
A
T
G
--------
K
M
Y
-----
A
C
K
K
L
Q
K
K
R
---
I
K
K
------------------------------
R
K
G
E
A
--
M
A
L
N
E
K
R
I
L
E
K
V
Q
S
R
-------
F
-
V
V
S
L
A
Y
A
Y
E
T
K
D
-----
A
L
C
L
V
L
T
I
M
-
N
G
G
--
D
L
K
F
H
I
YNLGNPGFD
E
Q
R
------
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
----------
Q
R
----
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
------
D
R---
G
----
H
I
R
I
S
--
D
L
G
L
A
T
E
I
P
E
G
Q
------
R
V
R
G
R
V
G
T
V
G
Y
--
M
A
P
E
V
--
V
N
NEK-------
Y
-----
T
F
S
P
D
W
W
G
L
-
G
C
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
50.09
14%
-43
- C3 -
4XBR
3
F212A_HUMAN
A:
[108-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
V
C
I
A
T
V
R
----
S
S
G
--------
K
L
V
-----
A
V
K
K
M
D
L
R
K
---
Q
---------------------------------
Q
R
R
E
--
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
-------
N
-
V
V
E
M
Y
N
S
Y
L
V
G
D
-----
E
L
W
V
V
M
E
F
L
-
E
G
G
--
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
---------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
----------
H
A
----
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
------
H
D---
G
----
R
V
K
L
S
--
D
F
G
F
C
A
Q
V
S
K
E
V
-----
P
R
R
K
S
L
V
G
T
P
Y
W
--
M
A
P
E
L
--
I
-----------
S
RLPY-
G
P
E
V
D
I
W
S
L
-
G
I
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
49.75
14%
-41
- C3 -
4FIE
1
PAK4_HUMAN
A:
[165-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
V
C
I
A
T
V
R
----
S
S
G
--------
K
L
V
-----
A
V
K
K
M
D
L
R
K
---
Q
---------------------------------
Q
R
R
E
--
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
-------
N
-
V
V
E
M
Y
N
S
Y
L
V
G
D
-----
E
L
W
V
V
M
E
F
L
-
E
G
G
--
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
---------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
----------
H
A
----
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
------
H
D---
G
----
R
V
K
L
S
--
D
F
G
F
C
A
Q
V
S
K
E
V
-----
P
R
R
K
S
L
V
G
T
P
Y
W
--
M
A
P
E
L
--
I
SRLP-------
Y
-----
G
P
E
V
D
I
W
S
L
-
G
I
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
48.73
25%
-9
- C3 -
4H05
-
?
A:
[1-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
D
A
L
R
A
L
R
G
R
Y
PG
C
E
W
V
V
V
E
D
G
A
S
G
A
G
V
--------
Y
R
L
R
G
G
G
R
E
L
F
V
K
V
A
A
L
G
A
G
V
G
L
L
--------
G
E
A
E
R
L
V
W
L
A
E
V
G
I
P
V
P
R
V
V
E
G
G
--------
G
D
E
R
V
A
W
L
V
-----
T
E
A
V
P
G
R
P
A
S
A
R
W
--
P
R
E
Q
R
L
D
V
A
V
A
L
A
G
L
-----
A
R
S
L
H
A
L
D
W
E
R
C
P
F
D
R
-----
S
L
A
V
T
V
P
Q
A
A
R
A
V
A
E
G
S
V
D
L
E
------------------
D
L
D
E
E
R
K
G
W
S
G
E
R
L
L
A
E
L
E
R
T
RPAD
E
D
----
L
A
V
C
H
G
D
L
C
P
D
N
V
L
L
D
PRTCEV
T
----
G
----
L
I
D
V
G
--
R
V
G
R
A
D
R
H
S
D
L
A
L
-
V
L
R
E
L
A
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
48.67
14%
-32
- C3 -
3V8S
1
ROCK1_HUMAN
A:
[83-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
V
Q
L
V
R
H
K
----
S
T
R
--------
K
V
Y
-----
A
M
K
L
L
S
K
F
E
---
M
I
K
------------------------------
R
S
D
S
A
--
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
-------
W
-
V
V
Q
L
F
Y
A
F
Q
D
D
R
-----
Y
L
Y
M
V
M
E
Y
M
-
P
G
G
--
D
L
V
N
L
M
S
N
YDVP
E
K
W
---------
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
----------
H
S
----
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
------
K
S---
G
----
H
L
K
L
A
--
D
F
G
T
C
M
K
M
N
K
E
G
M
----
V
R
C
D
T
A
V
G
T
P
D
Y
--
I
S
P
E
V
--
L
K
S
QGGD
G
Y
---
Y
-----
G
R
E
C
D
W
W
S
V
-
G
V
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
48.06
14%
-20
- C3 -
4CZU
5
CIPKN_ARATH
A:
[25-210]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
K
F
A
R
N
V
----
E
N
G
--------
D
N
V
-----
A
I
K
V
I
D
K
E
K
---
V
L
-----------------------------
K
-
N
K
M
I
A
--
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
-------
N
-
V
I
R
M
F
E
V
M
A
S
K
T
-----
K
I
Y
F
V
L
E
F
V
-
T
G
G
--
E
L
F
D
K
I
S
S
NGRLK
E
D
E
--------
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
----------
H
S
----
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
------
A
N---
G
----
A
L
K
V
S
--
D
F
G
L
S
A
L
P
Q
Q
V
R
E
---
D
G
L
L
H
D
T
C
G
T
P
N
Y
--
V
A
P
E
V
--
I
-----------
N
NKGYD
G
A
K
A
D
L
W
S
C
-
G
V
I
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
47.73
12%
-31
- C3 -
2VD5
1
DMPK_HUMAN
A:
[75-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
V
A
V
V
K
M
K
----
Q
T
G
--------
Q
V
Y
-----
A
M
K
I
M
N
K
W
D
---
M
L
-----------------------------
K
-
R
G
E
V
S
--
C
F
R
E
E
R
D
V
L
V
N
G
D
R
R
-------
W
-
I
T
Q
L
H
F
A
F
Q
D
E
N
-----
Y
L
Y
L
V
M
E
Y
Y
-
V
G
G
--
D
L
L
T
L
L
S
K
FGERIP
A
E
M
-------
A
R
F
Y
L
A
E
I
V
M
A
I
D
S
V
----------
H
R
----
L
G
Y
V
H
R
D
I
K
P
D
N
I
L
L
D
------
R
C---
G
----
H
I
R
L
A
--
D
F
G
S
C
L
K
L
R
A
D
G
T
----
V
R
S
L
V
A
V
G
T
P
D
Y
--
L
S
P
E
I
--
L
Q
A
V
G
GGPGTGS
Y
-----
G
P
E
C
D
W
W
A
L
-
G
V
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
47.52
13%
-38
- C3 -
4FR4
1
ST32A_HUMAN
A:
[29-217]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
V
C
I
V
Q
K
N
----
D
T
K
--------
K
M
Y
-----
A
M
K
Y
M
N
K
Q
K
---
C
V
E
------------------------------
R
N
E
V
R
--
N
V
F
K
E
L
Q
I
M
Q
G
L
E
H
P
-------
F
-
L
V
N
L
W
Y
S
F
Q
D
E
E
-----
D
M
F
M
V
V
D
L
L
-
L
G
G
--
D
L
R
Y
H
L
Q
Q
N
V
H
F
K
E
E
T
--------
V
K
L
F
I
C
E
L
V
M
A
L
D
Y
L
----------
Q
N
----
Q
R
I
I
H
R
D
M
K
P
D
N
I
L
L
D
------
E
H---
G
----
H
V
H
I
T
--
D
F
N
I
A
A
M
L
P
R
E
T
------
Q
I
T
T
M
A
G
T
K
P
Y
--
M
A
P
E
M
--
F
SSRKGAG----
Y
-----
S
F
A
V
D
W
W
S
L
-
G
V
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
47.36
16%
-42
* C3 *
3I6U
-
CHK2_HUMAN
A:
[232-417]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
V
K
L
A
F
E
R
----
K
T
C
--------
K
K
V
-----
A
I
R
I
I
S
K
R
K
---
F
A
I
--------
G
-------------------------
L
--
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
-------
C
-
I
I
K
I
K
N
F
F
D
A
-
E
-----
D
Y
Y
I
V
L
E
L
M
-
E
G
G
--
E
L
F
D
K
V
VGNKRLK
E
A
T
--------
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
----------
H
E
----
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
QEE
D
C
----
L
I
K
I
T
--
D
F
G
H
S
K
I
L
G
-----------------
P
T
Y
--
L
A
P
E
V
--
L
VAG--------
Y
-----
N
R
A
V
D
C
W
S
L
-
G
V
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
46.88
13%
-30
- C3 -
4BKY
2
MELK_HUMAN
A:
[24-201]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
K
L
A
C
H
I
----
L
T
G
--------
E
M
V
-----
A
I
K
I
M
D
K
N
T
---
L
----------------------------------
D
L
P
--
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
-------
H
-
I
C
Q
L
Y
H
V
L
E
T
A
N
-----
K
I
F
M
V
L
E
Y
C
-
P
G
G
--
E
L
F
D
Y
I
I
S
Q
DRLS
E
E
E
--------
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
----------
H
S
----
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
------
E
Y---
H
----
K
L
K
L
I
--
D
F
G
L
C
A
-------------------
S
L
A
Y
--
A
A
P
E
L
--
I
-----------
Q
GK---
G
S
E
A
D
V
W
S
M
-
G
I
L
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
46.85
11%
-40
- C3 -
3TKI
2
CHK1_HUMAN
A:
[21-199]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
V
Q
L
A
V
N
R
----
V
T
E
--------
E
A
V
-----
A
V
K
I
V
D
M
K
--------------------------------------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
-------
N
-
V
V
K
F
Y
G
H
R
R
E
G
N
-----
I
Q
Y
L
F
L
E
Y
C
-
S
G
G
--
E
L
F
D
R
I
EPDIGMP
E
P
D
--------
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
----------
H
G
----
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
------
E
R---
D
----
N
L
K
I
S
--
D
F
G
L
A
T
V
F
R
Y
N
N
R
---
E
R
L
L
N
K
M
C
G
T
L
P
Y
--
V
A
P
E
L
--
L
-----------
K
RREFH
A
E
P
V
D
V
W
S
C
-
G
I
V
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
45.89
12%
-31
- C3 -
4TND
2
GRK5_HUMAN
A:
[198-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
V
C
A
C
Q
V
R
----
A
T
G
--------
K
M
Y
-----
A
C
K
R
L
E
K
K
R
---
I
K
K
------------------------------
R
K
G
E
S
--
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
Q
-------
F
-
V
V
N
L
A
Y
A
Y
E
T
K
D
-----
A
L
C
L
V
L
T
I
M
-
N
G
G
--
D
L
K
F
H
I
Y
NMGNPGFE
E
E
R
------
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
----------
H
H
----
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
------
D
Y---
G
----
H
I
R
I
S
--
D
L
G
L
A
V
K
I
P
E
G
D
------
L
I
R
G
R
V
G
T
V
G
Y
--
M
A
P
E
V
--
L
N
NQR-------
Y
-----
G
L
S
P
D
Y
W
G
L
-
G
C
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
45.71
13%
-32
- C3 -
5IG1
3
?
A:
[30-209]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
S
T
V
H
R
C
V
N
K
----
R
T
G
--------
E
V
C
-----
A
V
K
V
I
A
L
K
S
---
L
R
-------------------------------
S
S
E
I
N
--
K
I
K
R
E
I
G
I
C
S
S
L
Q
H
E
-------
H
-
I
V
S
M
R
R
A
F
R
D
E
S
-----
H
F
Y
L
V
F
E
Y
V
-
S
G
G
--
E
L
F
D
E
I
V
T
RKFYN
E
K
D
--------
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
----------
H
S
----
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
A
SKD---
P
N---
A
----
P
V
K
I
T
--
D
F
G
L
A
V
I
M
E
Q
G
P
------
T
Y
F
G
F
A
G
T
P
G
Y
--
L
S
P
E
V
--
I
R
RVP-------
Y
-----
D
T
A
V
D
V
W
A
C
-
G
V
I
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
44.54
13%
-27
- C3 -
4D28
-
CIPKO_ARATH
A:
[23-201]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
K
F
A
R
N
T
----
D
T
G
--------
D
N
V
-----
A
I
K
I
M
A
K
S
T
---
I
L
K
------------------------------
N
R
M
V
D
--
Q
I
K
R
E
I
S
I
M
K
I
V
R
H
P
-------
N
-
I
V
R
L
Y
E
V
L
A
S
K
S
-----
K
I
Y
I
V
L
E
F
V
-
T
G
G
--
E
L
F
D
R
I
V
H
K
GRLK
E
D
E
--------
S
R
K
Y
F
Q
Q
L
V
D
A
V
A
H
C
----------
H
S
----
K
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
------
T
N---
G
----
N
L
K
V
S
--
D
F
G
L
S
A
L
P
Q
E
G
--------
L
N
D
T
C
G
T
P
N
Y
--
V
A
P
E
V
--
L
-----------
S
GQGYD
G
S
A
A
D
I
W
S
C
-
G
V
I
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
44.24
15%
-36
- C3 -
2YAB
4
DAPK2_MOUSE
A:
[26-209]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
V
K
K
C
R
E
K
----
S
T
G
--------
L
E
Y
-----
A
A
K
F
I
K
K
R
Q
---
S
R
A
--------------------------
S
R
R
-
G
V
C
R
E
--
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
-------
N
-
I
I
T
L
H
D
V
Y
E
N
R
T
-----
D
V
V
L
I
L
E
L
V
-
S
G
G
--
E
L
F
D
F
L
A
Q
KESLS
E
E
E
--------
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
----------
H
T
----
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
------
D
K---
N
IP
I
P
H
I
K
L
I
--
D
F
G
L
A
H
E
I
E
D
G
V
------
E
F
K
N
I
F
G
T
P
E
F
--
V
A
P
E
I
--
V
N
YEP-------
L
-----
G
L
E
A
D
M
W
S
I
-
G
V
I
T
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
43.83
16%
-21
- C3 -
5D9H
2
STK39_MOUSE
A:
[32-223]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
V
Q
A
A
L
C
K
----
P
R
Q
--------
E
R
V
-----
A
I
K
R
I
N
L
E
K
---
C
Q
--------------------------------
T
S
M
D
--
E
L
L
K
E
I
Q
A
M
S
Q
C
S
H
P
-------
N
-
V
V
T
Y
Y
T
S
F
V
V
K
D
-----
E
L
W
L
V
M
K
L
L
-
S
G
G
--
S
M
L
D
I
I
K
Y
I
V
N
R
GEHKNGVLE
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
----------
H
R
----
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
------
E
D---
G
----
S
V
Q
I
A
--
D
F
G
V
S
A
F
L
A
T
G
G
D
V
T
R
-------
V
G
T
P
C
W
--
M
A
P
E
V
--
M
E
Q
V
R
G------
Y
-----
D
F
K
A
D
M
W
S
F
-
G
I
T
A
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
42.36
10%
-39
- C3 -
4ZHX
2
?
A:
[41-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
V
K
I
G
E
H
Q
----
L
T
G
--------
H
K
V
-----
A
V
K
I
L
N
R
Q
K
---
I
R
-----------------------------
S
-
L
D
V
V
G
--
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
-------
H
-
I
I
K
L
Y
Q
V
I
S
T
P
T
-----
D
F
F
M
V
M
E
Y
V
-
S
G
G
--
E
L
F
D
Y
I
C
K
H
GRVE
E
M
E
--------
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
----------
H
R
----
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
------
A
H---
M
----
N
A
K
I
A
--
D
F
G
L
S
N
M
M
S
D
G
E
------
F
L
R
T
S
C
G
S
P
N
Y
--
A
A
P
E
V
--
I
-----------
S
GRLYA
G
P
E
V
D
I
W
S
C
-
G
V
I
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
41.29
11%
-29
- C3 -
2PZI
2
PKNG_MYCTU
A:
[93-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
G
W
I
Y
L
A
L
D
R
N
---
V
N
G
--------
R
P
V
-----
V
L
K
G
L
V
H
S
G
---
D
A
--------------------------------
E
A
Q
A
--
M
A
M
A
E
R
Q
F
L
A
E
V
V
H
P
-------
S
-
I
V
Q
I
F
N
F
V
E
H
T
D
RHG
D
P
V
G
Y
I
V
M
E
Y
V
-
G
G
Q
--
S
L
K
---QKLP
V
A
E
-----------
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
----------
H
S
----
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
T
------
E
----
E
----
Q
L
K
L
I
--
D
L
G
A
V
S
R
I
N
S
---------
F
G
Y
L
Y
G
T
P
G
F
--
Q
A
P
E
I
--
V
-----------
R
TGP--
T
V
A
T
D
I
Y
T
V
-
G
R
T
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------