@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0667: (2016-04-24 )
MADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA
Atome Classification :
(43 SA)
.........10........20........30........40........50........60---........70........80........90.---.---......100.......110.......120.......130..-------.....-------140.......150.......160.......170.......180.....--.--.-190.......200.......210.......220.......230.......240.-...--------------------------------------------------------.-..--------250------------------------------------------------------------....-------------------------------.-...-260......--------------------------------------------------------------------------.270.......280.......290.......300.......310......-.----320.---..-....330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.....-------..660-----..-------.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850----------------------------------------------------------------------------------------------------.-......860.......870.......880.......890.......900.......910.......920.......930....-...940---.......---.950----...--------------------....960---------------------.----......970.......980..--------------....--------------.990.......---------------------1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MADSRQSKTAASPSPSRPQSSSNNSVPGAPNR
V
S
F
A
K
L
REPLEVP
G
L
L
D
VQTDS
F
E
W
LIGS---
P
R
W
R
E
S
AAERGDVNPVG
G
L
E
E
V
L
Y
E
LS
P
I
E
D---F---SG
S
M
S
L
SFSDPRFDDVKA
P
V
D
ECKDKDM
T
Y
AA
P
L
F
V
T
A
E
F
I-------NNNTG-------E
I
K
S
Q
T
V
F
MGDFPMMTEK
G
T
F
I
ING
T
E
R
V
V
V
S
Q
L
V
RSPGVYFDETIDK--S--T-DK
T
L
H
S
V
K
V
IPSRG
A
W
L
E
F
DVDKR
D
T
V
G
V
R
IDRKRRQ
P
V
T
V
L
L
K
A
LGW
T
S
E
Q
I
V
-
E
RF--------------------------------------------------------
G
-
F
S
--------
E
I
-------------------------------------------------------------
M
R
S
T
-------------------------------L-EKD-NTVG
T
D
E
A
L
--------------------------------------------------------------------------
L
D
I
Y
R
K
LRPGEPP
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
VG
R
Y
K
VN
K
K
LGLHV-G----EPIT---SS-TL
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
LHEG
Q
T
T
M
TVPG
G
V
E
VPVETD
D
I
D
H
FGN
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
RMTTQ
D
V
EAITPQ
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
DQNNPLS
G
L
T
H
K
R
R
L
SALGPGGLSRERAG
L
E
V
RDVHPSHYGRMCPIETPEGPN
I
G
L
I
GS
L
S
V
Y
A
R
VNPFGFIE
T
P
Y
R
K
V
V
D
G
VVSD
E
I
V
Y
L
TADEED
R
H
V
V
AQANSPIDADG
R
F
VE
P
R
V
L
V
R
RKAG
E
V
E
YVPSSEV
D
Y
MDV
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
LEHDDANRALMGANMQRQAVPLVRSEAPLVGTG
M
E
L
R
A
AIDAG
D
V
V
V
AEESG
V
I
E
EVSA
D
Y
I
T
V
M
HD-------NGT-------
R
R
-------
T
Y
R
M
R
K
F
A
RSNHGTCANQCPIVDAGDRVEAG
Q
V
I
ADGPCTDDG
E
M
ALGK
N
L
L
V
A
I
MPWEGHNYE
D
A
I
I
LSNRLV
E
E
DV
L
T
S
I
H
I
E
EHEIDARDTKL
G
A
E
E
I
T
R
DIPNI
S
D
E
V
L
A
D
L
DER
G
I
V
R
IGAEVRDG
D
I
L
V
G
K
VTPKGETEL
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
VRDTSLKVPHGES
G
K
V
I
G
I
R
V
FSREDE----------------------------------------------------------------------------------------------------D-EL
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
KRKISDGD
K
L
AGRHGNKGVIGKILPVEDMPFLADG
T
P
V
D
I
I
L
NTHGVPRRM
N
I
G
Q
I
L
E
T
H
L
G
W
CAHS-G
W
K
VD----AAKGV
P
D
---
W
A
A
R----L
P
D
--------------------
E
L
L
EAQP---------------------N----
A
I
V
STPVFDG
A
Q
E
A
E
L
Q
G
L
L
S--------------CTLP--------------NRDG
D
V
L
VDAD---------------------G
K
A
M
L
F
DGRSGEPF
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
VDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGE
M
E
C
W
A
M
Q
AY
G
A
A
Y
T
L
Q
E
L
L
TIKSDDTV
G
R
V
K
V
Y
E
A
I
V
KGENIPEPGI
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
LSSDG
A
A
I
E
LREGE
D
E
D
L
E
R
A
A
A
NLG
I
N
LSRNESASVEDLA
100
HHSearch
87.61
56%
-66
- C6 -
4YFK
2
RPOB_ECO24
C:
[5-1341]
------------------------
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
---
D
-----------
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
---
Y
---
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
-------
I
Y
E
R
E
APEGTVK
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
--
T
HS
S
-
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
-
D
L
F
--------------------------------------------------------
F
-
E
K
V
I
F
E
IRDN
K
L
Q
M
E
L
---------------------------------------------------------
V
P
E
R
LRGETASFDIEANGKVYVEKGRRIT
A
R
H
I
R
Q
L
-
E
K
D
-
D
V
K
L
I
E
V
P
V
EYIAG
K
V
V
A
K
DYIDESTGELICAAN
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
GHK
R
I
E
T
L
FTNDLDHGPY
I
S
E
T
L
R
V
DPTND
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
-
I
----
E
--
G
---
S
G
-
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
------------
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
-
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
-------
E
D
E
MYPGE
A
G
I
D
-------
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
EKD
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
GGVEAEKLDKLPRDRWLE
L
G
L
T
DEE
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
QG
D
-
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
----
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
--------------------
L
G
A
D
V
R
Q
K
V
D
LSTFSD
E
E
V
M
R
L
A
E
N
L
R
K
G
----
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
--------------
L
G
----------------------
D
L
P
T
S
---------------------
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
---------------------------------------
118
Fugue
86.11
56%
-63
- C6 -
3LU0
-
RPOB_ECOLI
C:
[8-1342]
---------------------------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
--------------
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
---
Y
---
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
IYEREAP
E
G
T
V
K
-------
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
TH
S
--
S
-
G
K
V
L
Y
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A
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I
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W
L
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A
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I
L
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A
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I
L
-
D
L
F
FEKVIFEIRDNKLQMELVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKD
D
-
V
K
--------
L
I
EVPVEYIAGKVVAKDYIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPY
I
S
E
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
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P
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A
A
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L
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L
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---
E
----
E
I
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---
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G
-
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------------
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V
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Q
Y
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A
S
R
I
V
I
K
V
N
EDEMYPG
E
A
G
-------
I
D
-------
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
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C
I
N
Q
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L
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G
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K
A
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K
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R
V
P
N
G
V
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T
V
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V
Q
V
F
T
R
D
G
V
EKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQG
D
-
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
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D
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G
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I
G
Q
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A
K
G
I
G
D
K
I
N
AMLK
Q
Q
Q
E
V
A
K
---
L
R
E
F
----
I
Q
R
AYDLGADVRQKVDLSTFSDE
E
V
M
R
L
A
E
---------------------
N
LRKG
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
--------------
L
G
D
L
--------------
P
T
S
G
Q
I
R
-----------------------------
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
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L
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P
L
G
G
K
A
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F
G
G
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M
E
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W
A
L
E
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A
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L
T
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G
R
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V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
--------------------------------------
28
PsiBlast_CBE
83.71
49%
-72
- C6 -
4OIQ
3
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
---------
G
L
V
L
D
F
L
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R
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G
E
P
P
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Q
D
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C
R
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K
D
L
T
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L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
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V
F
L
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H
I
P
L
M
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--
T
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--
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--
R
P
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A
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L
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N
G
V
V
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V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
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D
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K
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K
A
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A
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---
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-----
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L
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R
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-------
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-------
L
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R
L
R
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P
----------------------------------------------------------------------------------------------------
G
V
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R
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R
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Q
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T
H
L
G
L
A
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Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
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L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
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I
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G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
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K
M
H
A
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P
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L
I
T
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K
A
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F
G
E
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A
L
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A
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G
A
A
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T
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E
M
L
T
L
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S
D
D
I
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R
N
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K
G
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L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
29
PsiBlast_CBE
83.69
49%
-70
- C6 -
4OIP
5
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
---------
G
L
V
L
D
F
L
E
Y
R
L
G
E
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P
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D
E
C
R
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D
L
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L
Y
A
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L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
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D
G
S
F
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G
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P
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--
T
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D
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--
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--
R
P
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R
Y
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A
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L
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L
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N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
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---
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H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
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V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
G
R
-------
L
V
-------
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Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
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V
V
V
G
Q
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V
R
K
G
D
L
L
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G
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A
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V
L
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L
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Y
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I
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A
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L
S
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V
V
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G
A
E
V
K
P
G
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I
L
V
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F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
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I
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P
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V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
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K
M
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A
R
S
T
G
P
Y
S
L
I
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Q
P
L
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A
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G
G
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F
G
E
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E
V
W
A
L
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A
A
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E
M
L
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L
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D
D
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R
N
A
A
Y
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A
I
I
K
G
E
D
V
P
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V
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E
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A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
27
PsiBlast_CBE
83.61
49%
-71
- C6 -
4OIR
4
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
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A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
---------
G
L
V
L
D
F
L
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Y
R
L
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E
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P
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P
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D
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C
R
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D
L
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A
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L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
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V
F
L
G
H
I
P
L
M
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D
G
S
F
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A
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V
I
V
S
Q
I
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R
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P
G
V
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F
--
T
P
D
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--
A
--
R
P
G
R
Y
I
A
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I
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L
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L
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V
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P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
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A
Y
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L
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A
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---
D
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A
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-------
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-------
L
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-------
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L
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P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
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V
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V
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M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
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P
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G
P
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V
V
G
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M
F
I
M
K
L
Y
H
M
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D
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M
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A
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S
L
I
T
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L
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A
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W
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A
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L
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R
N
A
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V
Q
T
L
D
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K
D
N
P
V
D
I
F
E
G
----------------------------
22
PsiBlast_CBE
83.50
49%
-70
- C6 -
5E17
2
?
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
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P
L
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I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
---------
G
L
V
L
D
F
L
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Y
R
L
G
E
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P
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D
L
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A
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L
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-------
H
K
D
T
G
-------
L
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L
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L
M
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G
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F
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N
G
A
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P
G
V
Y
F
--
T
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D
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--
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--
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N
G
V
V
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M
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V
N
-
K
R
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P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
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L
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D
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A
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A
Y
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---
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L
F
A
L
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-----
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----------------------------------------------------------------------------------------------------
G
V
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T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
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V
L
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R
A
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L
GLVTPGKT
P
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L
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M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
31
PsiBlast_CBE
83.49
49%
-70
- C6 -
4OIN
4
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
---------
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
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L
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L
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L
-
S
GRTL
A
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F
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---
D
G
-
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F
K
D
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V
F
L
P
T
L
R
Y
L
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A
L
T
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-----
V
P
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H
-----
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L
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G
L
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G
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V
H
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Y
G
R
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C
P
V
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T
P
E
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A
N
I
G
L
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L
A
A
Y
A
R
V
D
E
L
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T
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V
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T
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Q
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R
A
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M
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P
L
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R
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A
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V
V
M
T
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L
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V
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S
L
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Y
A
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G
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G
N
R
I
V
V
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Y
E
-------
D
G
R
-------
L
V
-------
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N
Q
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T
P
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R
L
L
R
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I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
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R
H
G
N
K
G
V
V
A
K
I
L
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D
M
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L
P
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G
T
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V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
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R
F
G
E
M
E
V
W
A
L
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A
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G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
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A
I
I
K
G
E
D
V
P
E
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S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
36
PsiBlast_CBE
83.47
49%
-72
- C6 -
4G7H
2
RPOB_THET8
M:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
----------
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
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P
W
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D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
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L
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S
GRTL
A
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F
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---
D
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Y
L
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A
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-----
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-----
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V
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P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
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V
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V
A
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R
K
L
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I
L
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M
P
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L
N
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L
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V
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R
M
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L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
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K
M
H
A
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S
T
G
P
Y
S
L
I
T
Q
Q
P
L
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G
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A
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F
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W
A
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A
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L
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R
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A
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A
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D
V
Q
T
L
D
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K
D
N
P
V
D
I
F
E
G
----------------------------
17
PsiBlast_PDB
83.45
49%
-72
- C6 -
4G7H
2
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
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L
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P
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E
I
Q
V
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Y
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R
A
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P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
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T
F
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E
----------
L
V
L
D
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L
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D
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-------
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-------
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K
E
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P
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M
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A
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V
Y
F
--
T
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--
A
--
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Y
I
A
S
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L
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N
G
V
V
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V
N
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K
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L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
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D
P
P
K
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K
A
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A
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S
GRTL
A
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F
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---
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Y
L
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A
L
T
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-----
V
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-----
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L
A
A
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L
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R
I
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-------
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R
-------
L
V
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P
T
P
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L
L
R
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E
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A
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V
K
D
T
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V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
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I
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M
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M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
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K
L
GLVTPGKT
P
E
E
Q
L
K
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L
F
L
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K
V
V
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R
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A
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L
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R
N
A
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A
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K
G
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A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
21
PsiBlast_CBE
83.41
49%
-68
- C6 -
5E18
2
?
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
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A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
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T
F
P
I
E
E
---------
G
L
V
L
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F
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L
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L
I
-------
H
K
D
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G
-------
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L
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--
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--
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--
R
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G
V
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N
-
K
R
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P
L
V
L
L
L
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V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
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---
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V
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R
L
R
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G
D
P
----------------------------------------------------------------------------------------------------
G
V
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M
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Q
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L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
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K
L
GLVTPGKT
P
E
E
Q
L
K
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L
F
L
Q
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K
V
V
L
Y
D
G
R
T
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P
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M
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M
K
L
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M
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L
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A
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A
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L
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D
V
Q
T
L
D
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K
D
N
P
V
D
I
F
E
G
----------------------------
26
PsiBlast_CBE
83.40
49%
-70
- C6 -
4Q4Z
4
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
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P
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I
Q
V
E
S
Y
R
R
A
L
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A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
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A
F
R
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T
F
P
I
E
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---------
G
L
V
L
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F
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L
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-------
H
K
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-------
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--
T
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--
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--
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N
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V
V
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N
-
K
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P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
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P
P
K
R
D
K
A
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A
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GRTL
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---
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P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
18
PsiBlast_PDB
83.32
49%
-68
- C6 -
4G7O
3
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
----------
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
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L
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R
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L
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G
R
Y
K
A
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K
L
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R
L
-
S
GRTL
A
R
F
E
---
D
G
-
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F
K
D
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F
L
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T
L
R
Y
L
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A
L
T
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-----
V
P
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-----
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L
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S
L
R
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K
R
R
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G
G
L
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R
A
G
F
D
V
R
D
V
H
R
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H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
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M
T
A
T
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A
N
T
P
L
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N
-
R
I
A
A
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V
V
A
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R
K
-
G
E
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V
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V
S
P
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M
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P
K
Q
V
F
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V
N
T
N
L
I
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F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
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A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
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V
V
R
D
S
L
A
A
L
Y
A
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D
G
E
V
A
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V
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G
N
R
I
V
V
R
Y
E
-------
D
G
R
-------
L
V
-------
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P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
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V
V
G
Q
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V
R
K
G
D
L
L
A
D
G
P
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G
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L
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D
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K
L
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H
L
S
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A
A
L
R
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L
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G
V
V
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A
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K
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D
I
L
V
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R
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S
F
K
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S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
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A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
30
PsiBlast_CBE
83.16
49%
-68
- C6 -
4OIO
5
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
----------
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
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L
I
A
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R
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Y
D
L
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E
A
G
R
Y
K
A
E
E
K
L
G
I
R
L
-
S
GRTL
A
R
F
E
---
D
G
-
E
F
K
D
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V
F
L
P
T
L
R
Y
L
F
A
L
T
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G
-----
V
P
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H
-----
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L
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R
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G
L
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A
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V
H
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G
R
I
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T
P
E
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A
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I
G
L
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L
A
A
Y
A
R
V
D
E
L
G
F
I
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T
P
Y
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R
V
V
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G
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E
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V
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A
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I
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V
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E
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P
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T
N
L
I
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D
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A
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R
A
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M
Q
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L
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A
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V
V
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L
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S
L
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Y
A
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E
V
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N
R
I
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E
-------
D
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R
-------
L
V
-------
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L
R
R
F
Y
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N
Q
G
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A
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D
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V
V
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L
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F
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L
L
R
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A
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K
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R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
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D
K
L
A
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R
H
G
N
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G
V
V
A
K
I
L
P
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D
M
P
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L
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T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
34
PsiBlast_CBE
83.13
49%
-65
- C6 -
4G7Z
2
RPOB_THET8
M:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
----------
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
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L
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-------
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-------
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--
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T
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A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
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L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
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P
G
E
G
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V
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L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
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P
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V
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K
L
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I
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M
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L
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Q
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L
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T
H
L
G
L
A
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F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
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E
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P
I
V
V
G
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V
Q
T
L
D
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K
D
N
P
V
D
I
F
E
G
----------------------------
35
PsiBlast_CBE
83.02
49%
-67
- C6 -
4G7O
3
RPOB_THET8
M:
[6-1114]
----------------------------------
F
G
R
I
R
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V
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L
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P
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P
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V
----------
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----------
L
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-------
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-------
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--
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--
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--
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-
K
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L
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L
L
L
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V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
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----------------------------------------------------------------------------------------------------
G
V
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Q
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L
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T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
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E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
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R
T
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P
I
V
V
G
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M
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L
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L
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L
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D
N
P
V
D
I
F
E
G
----------------------------
19
PsiBlast_PDB
82.93
49%
-65
- C6 -
4G7Z
2
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
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P
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----------
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----------
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-------
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--
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L
L
L
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V
L
G
Y
D
Q
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T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
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L
L
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K
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A
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GRTL
A
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---
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A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
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V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
G
R
-------
L
V
-------
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Y
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L
R
R
F
Y
R
S
N
Q
G
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A
L
D
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V
V
G
Q
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V
R
K
G
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L
L
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G
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N
V
L
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M
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L
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Y
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I
E
A
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L
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L
S
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V
V
R
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G
A
E
V
K
P
G
D
I
L
V
G
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S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
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N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
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P
I
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G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
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D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
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G
K
A
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F
G
G
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R
F
G
E
M
E
V
W
A
L
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G
A
A
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T
L
Q
E
M
L
T
L
K
S
D
D
I
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R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
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V
P
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F
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V
L
V
K
E
L
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A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
25
PsiBlast_CBE
82.76
49%
-68
- C6 -
4Q5S
4
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
----------
L
V
L
D
F
L
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Y
R
L
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D
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R
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K
D
L
T
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L
Y
A
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L
Q
L
I
-------
H
K
D
T
G
-------
L
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K
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V
F
L
G
H
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P
L
M
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D
G
S
F
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G
A
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V
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V
S
Q
I
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S
P
G
V
Y
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--
T
P
D
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--
A
--
R
P
G
R
Y
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A
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L
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K
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W
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L
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V
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N
G
V
V
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M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
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P
G
D
P
P
K
R
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K
A
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---
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R
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L
L
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P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
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M
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L
G
Q
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L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
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L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
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P
I
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P
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V
V
G
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M
F
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M
K
L
Y
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M
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L
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V
Q
T
L
D
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K
D
N
P
V
D
I
F
E
G
----------------------------
32
PsiBlast_CBE
82.40
49%
-68
- C6 -
4MQ9
2
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
--------------
L
D
F
L
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Y
R
L
G
E
P
P
F
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L
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L
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-------
H
K
D
T
G
-------
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V
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L
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N
G
A
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Y
F
--
T
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--
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--
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V
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N
-
K
R
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P
L
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L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
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V
F
A
M
R
P
E
E
A
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--------------------------------------------------------------------------
I
R
L
F
T
L
L
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A
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GRTL
A
------------
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-----
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G
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----------------------------------------------------------------------------------
Y
I
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P
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F
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G
A
K
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P
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K
E
L
L
A
--------------
Q
A
F
E
V
Y
F
GKRKGEGFGVD
K
R
E
V
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V
L
R
R
A
E
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L
GLVTPGKT
P
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A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
54
PsiBlast_CBE
81.96
49%
-63
- C6 -
4XLN
1
?
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
K
K
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
K
E
T
F
P
I
E
E
---
G
-----
G
L
V
L
D
F
L
E
Y
R
I
G
D
P
P
F
S
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
L
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
A
S
G
V
V
T
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
V
R
E
L
S
--------------------------------------------------------
A
-
Y
G
--------
D
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
L
D
E
A
V
-
L
A
M
R
P
E
E
A
M
--------------------------------------------------------------------------
V
R
L
F
T
L
L
R
P
G
D
P
P
K
K
D
K
A
L
A
Y
L
F
G
L
L
A
D
P
K
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
V
G
L
S
G
----
R
T
L
V
RFE
D
G
-
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
-----
V
P
G
H
-----
E
V
D
D
I
D
H
L
G
N
R
R
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R
T
V
G
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L
M
A
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Q
F
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G
L
A
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R
G
V
R
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M
V
M
G
S
P
D
T
L
T
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A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
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E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
-
G
E
P
V
I
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
-------
D
G
R
-------
L
V
-------
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
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M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
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I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
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T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
G
R
L
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
V
F
D
G
A
T
E
P
E
I
K
E
L
L
A
EAFNLYFGKRQGEG
F
G
V
D
--------------
K
R
E
K
E
V
L
A
R
A
E
KLGLVSPGKSPEEQLKELFDL
G
K
V
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
53
PsiBlast_CBE
81.94
49%
-64
- C6 -
4XLN
1
?
I:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
K
K
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
K
E
T
F
P
I
E
E
---
G
-----
G
L
V
L
D
F
L
E
Y
R
I
G
D
P
P
F
S
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
L
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
A
S
G
V
V
T
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
V
R
E
L
S
--------------------------------------------------------
A
-
Y
G
--------
D
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
L
D
E
A
V
-
L
A
M
R
P
E
E
A
M
--------------------------------------------------------------------------
V
R
L
F
T
L
L
R
P
G
D
P
P
K
K
D
K
A
L
A
Y
L
F
G
L
L
A
D
P
K
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
V
G
L
S
G
----
R
T
L
V
RFE
D
G
-
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
-----
V
P
G
H
-----
E
V
D
D
I
D
H
L
G
N
R
R
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R
T
V
G
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L
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A
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Q
F
R
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G
L
A
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L
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R
G
V
R
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R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
-
G
E
P
V
I
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
-------
D
G
R
-------
L
V
-------
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
G
R
L
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
V
F
D
G
A
T
E
P
E
I
K
E
L
L
A
EAFNLYFGKRQGEG
F
G
V
D
--------------
K
R
E
K
E
V
L
A
R
A
E
KLGLVSPGKSPEEQLKELFDL
G
K
V
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
43
PsiBlast_CBE
81.93
49%
-61
- C6 -
2O5I
3
RPOB_THET8
M:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
EDK
G
---
K
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
I
R
L
-
S
GRTL
A
R
F
E
---
D
G
-
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
-----
V
P
G
H
-----
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
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A
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G
L
T
R
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A
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F
D
V
R
D
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H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
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L
A
A
Y
A
R
V
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L
G
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Y
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R
V
V
G
G
V
V
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E
V
V
Y
M
T
A
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E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
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F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
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H
D
D
A
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R
A
L
M
G
S
N
M
Q
T
Q
A
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P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
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D
S
L
A
A
L
Y
A
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E
D
G
E
V
A
K
V
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N
R
I
V
V
R
Y
E
-------
D
G
R
-------
L
V
-------
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Y
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L
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R
F
Y
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N
Q
G
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A
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Q
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G
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L
L
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P
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F
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A
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N
V
L
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P
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L
L
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A
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S
E
A
A
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D
L
D
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V
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I
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A
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V
K
P
G
D
I
L
V
G
R
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F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
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A
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G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
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S
V
P
E
S
F
R
V
L
V
K
E
L
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A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
41
PsiBlast_CBE
81.69
49%
-61
- C6 -
2PPB
6
RPOB_THET8
M:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
EDK
G
---
K
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
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D
G
S
F
I
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N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
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P
L
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K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
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A
Y
V
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S
GRTL
A
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---
D
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-----
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L
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-------
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-------
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S
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P
G
E
G
G
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V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
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V
Y
V
A
Q
K
R
K
L
Q
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L
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R
H
G
N
K
G
V
V
A
K
I
L
P
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M
P
H
L
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T
P
V
D
V
I
L
N
P
L
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V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
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F
G
G
Q
R
F
G
E
M
E
V
W
A
L
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A
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G
A
A
H
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L
Q
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M
L
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L
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D
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R
N
A
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A
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I
K
G
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V
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L
V
K
E
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A
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A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
23
PsiBlast_CBE
81.58
49%
-61
- C6 -
4WQS
2
RPOB_THET8
M:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
EDK
G
---
K
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
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G
S
F
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N
G
A
D
R
V
I
V
S
Q
I
H
R
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P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
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K
R
G
P
W
I
D
L
E
V
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P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
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Y
K
A
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L
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R
L
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S
GRTL
A
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F
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---
D
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-
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D
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F
L
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L
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A
L
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G
-----
V
P
G
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-----
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V
V
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V
R
L
R
R
G
D
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----------------------------------------------------------------------------------------------------
G
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R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
12
PsiBlast_PDB
81.52
49%
-62
- C6 -
2PPB
4
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
EDK
G
---
K
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
I
R
L
-
S
GRTL
A
R
F
E
---
D
G
-
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
-----
V
P
G
H
-----
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
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L
M
T
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Q
F
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L
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L
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R
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V
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R
M
L
M
G
S
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D
S
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A
K
L
V
N
S
R
P
L
E
A
A
I
R
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F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
G
R
-------
L
V
-------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
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N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
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I
H
I
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R
Y
E
I
E
A
R
D
T
K
L
G
P
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T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
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G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
24
PsiBlast_CBE
81.50
49%
-60
- C6 -
4WQS
2
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
EDK
G
---
K
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
I
R
L
-
S
GRTL
A
R
F
E
---
D
G
-
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
-----
V
P
G
H
-----
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
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A
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L
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V
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M
L
M
G
S
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A
K
L
V
N
S
R
P
L
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A
A
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F
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Q
L
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Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
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A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
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V
S
P
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E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
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L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
G
R
-------
L
V
-------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
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E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
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H
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Y
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A
R
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L
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P
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I
T
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D
I
P
H
L
S
E
A
A
L
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D
L
D
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V
V
R
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A
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V
K
P
G
D
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G
R
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F
K
G
E
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T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
10
PsiBlast_PDB
81.47
49%
-61
- C6 -
2O5I
3
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
EDK
G
---
K
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
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P
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P
P
K
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K
A
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A
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-
S
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A
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---
D
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L
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-----
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-----
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A
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T
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L
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N
-
R
I
A
A
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R
V
V
A
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K
-
G
E
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V
V
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R
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V
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-------
D
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-------
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-------
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E
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L
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I
F
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A
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T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
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N
K
G
V
V
A
K
I
L
P
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D
M
P
H
L
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T
P
V
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V
I
L
N
P
L
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V
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R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
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M
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A
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P
Y
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L
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Q
Q
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A
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F
G
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V
W
A
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G
A
A
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L
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M
L
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L
K
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D
D
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R
N
A
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A
I
I
K
G
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V
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V
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A
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A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
11
PsiBlast_PDB
81.26
49%
-61
- C6 -
2O5J
4
RPOB_THET8
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
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A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
EDK
G
---
K
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
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C
R
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K
D
L
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L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
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K
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D
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V
F
L
G
H
I
P
L
M
T
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G
A
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V
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--
T
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--
A
--
R
P
G
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Y
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K
R
G
P
W
I
D
L
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V
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P
N
G
V
V
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M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
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K
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A
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GRTL
A
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---
D
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-----
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-----
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A
A
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-------
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-------
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P
G
E
G
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V
V
R
T
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R
L
R
R
G
D
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----------------------------------------------------------------------------------------------------
G
V
E
L
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V
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K
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M
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L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
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E
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P
I
V
V
G
Q
M
F
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M
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L
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M
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A
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L
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A
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K
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A
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D
V
Q
T
L
D
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K
D
N
P
V
D
I
F
E
G
----------------------------
42
PsiBlast_CBE
81.25
49%
-60
- C6 -
2O5J
5
RPOB_THET8
M:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
EDK
G
---
K
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
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R
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L
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L
Y
A
R
L
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L
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-------
H
K
D
T
G
-------
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K
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V
F
L
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H
I
P
L
M
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G
A
D
R
V
I
V
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Q
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V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
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L
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K
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W
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L
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N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
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R
L
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GRTL
A
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---
D
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L
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A
L
T
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G
-----
V
P
G
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-----
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Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
51
PsiBlast_CBE
80.74
49%
-63
- C6 -
4XLR
1
RPOB_THEAQ
I:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
K
K
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
K
E
T
F
P
I
E
E
---
G
DKG
K
G
G
L
V
L
D
F
L
E
Y
R
I
G
D
P
P
F
S
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
L
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
A
S
G
V
V
T
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
V
R
E
L
S
--------------------------------------------------------
A
-
Y
G
--------
D
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
L
D
E
A
V
-
L
A
M
R
P
E
E
A
M
--------------------------------------------------------------------------
V
R
L
F
T
L
L
R
P
G
D
P
P
K
K
D
K
A
L
A
Y
L
F
G
L
L
A
D
P
K
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
V
G
L
S
G
----
R
T
L
V
RFE
D
G
-
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
-----
V
P
G
H
-----
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
A
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
-
G
E
P
V
I
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
-------
D
G
R
-------
L
V
-------
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
G
R
L
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
V
F
D
G
A
T
E
P
E
I
K
E
L
L
A
EAFNLYFGKRQGEG
F
G
V
D
--------------
K
R
E
K
E
V
L
A
R
A
E
KLGLVSPGKSPEEQLKELFDL
G
K
V
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
52
PsiBlast_CBE
80.67
49%
-63
- C6 -
4XLR
1
RPOB_THEAQ
C:
[6-1114]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
K
K
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
K
E
T
F
P
I
E
E
---
G
DKG
K
G
G
L
V
L
D
F
L
E
Y
R
I
G
D
P
P
F
S
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
L
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
A
S
G
V
V
T
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
V
R
E
L
S
--------------------------------------------------------
A
-
Y
G
--------
D
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
L
D
E
A
V
-
L
A
M
R
P
E
E
A
M
--------------------------------------------------------------------------
V
R
L
F
T
L
L
R
P
G
D
P
P
K
K
D
K
A
L
A
Y
L
F
G
L
L
A
D
P
K
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
V
G
L
S
G
----
R
T
L
V
RFE
D
G
-
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
-----
V
P
G
H
-----
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
A
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
-
G
E
P
V
I
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
-------
D
G
R
-------
L
V
-------
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
G
R
L
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
V
F
D
G
A
T
E
P
E
I
K
E
L
L
A
EAFNLYFGKRQGEG
F
G
V
D
--------------
K
R
E
K
E
V
L
A
R
A
E
KLGLVSPGKSPEEQLKELFDL
G
K
V
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
----------------------------
15
PsiBlast_PDB
80.60
49%
-61
- C6 -
3AOH
2
RPOB_THET8
C:
[6-1112]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
---------
G
L
V
L
D
F
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Y
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L
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P
Q
D
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C
R
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K
D
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A
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A
R
L
Q
L
I
-------
H
K
D
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G
-------
L
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K
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V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
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A
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V
I
V
S
Q
I
H
R
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--
T
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P
--
A
--
R
P
G
R
Y
I
A
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W
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L
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V
E
P
N
G
V
V
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M
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N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
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L
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P
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K
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K
A
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Y
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-
S
GRTL
A
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F
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---
D
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-
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F
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L
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-----
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-----
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P
L
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A
A
I
R
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F
F
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K
D
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T
N
P
L
S
S
L
R
H
K
R
R
I
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A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
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V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
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A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
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T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
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D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
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R
V
V
A
R
R
K
-
G
E
P
V
I
V
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P
E
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F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
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P
L
I
R
A
Q
A
P
V
V
M
T
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L
E
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V
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A
A
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Y
A
E
E
D
G
E
V
A
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N
R
I
V
V
R
Y
E
-------
D
G
R
-------
L
V
-------
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
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N
G
F
L
A
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G
Q
N
V
L
V
A
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P
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Y
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F
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A
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V
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S
E
E
L
L
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R
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T
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Y
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I
E
A
R
D
T
K
L
G
P
E
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H
L
S
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A
A
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R
D
L
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V
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I
G
A
E
V
K
P
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I
L
V
G
R
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P
T
P
E
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R
L
L
R
S
I
F
G
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K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
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G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
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E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
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S
V
P
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F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
------------------------------
16
PsiBlast_PDB
80.50
49%
-63
- C6 -
3AOI
2
RPOB_THET8
C:
[6-1112]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
---------
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
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G
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A
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Y
D
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A
G
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Y
K
A
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K
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G
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R
L
-
S
GRTL
A
R
F
E
---
D
G
-
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F
K
D
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V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
-----
V
P
G
H
-----
E
V
D
D
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N
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R
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S
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D
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R
P
L
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A
A
I
R
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F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
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G
A
N
I
G
L
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T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
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G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
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P
V
I
V
S
P
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V
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F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
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V
V
R
D
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L
A
A
L
Y
A
E
E
D
G
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V
D
G
N
R
I
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V
R
Y
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-------
D
G
R
-------
L
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-------
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Y
P
L
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R
F
Y
R
S
N
Q
G
T
A
L
D
Q
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V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
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A
L
G
Q
N
V
L
V
A
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M
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Y
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A
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Y
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A
R
D
T
K
L
G
P
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D
I
P
H
L
S
E
A
A
L
R
D
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D
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E
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V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
-----------------------
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
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D
K
L
A
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R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
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A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
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S
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P
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V
L
V
K
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A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
------------------------------
40
PsiBlast_CBE
80.49
49%
-63
- C6 -
3AOI
2
RPOB_THET8
H:
[6-1112]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
A
DVP
P
E
K
R
E
N
V
----------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
---------
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
-------
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
--
T
P
D
P
--
A
--
R
P
G
R
Y
I
A
S
I
I
P
L
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
-
K
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
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A
G
R
Y
K
A
E
E
K
L
G
I
R
L
-
S
GRTL
A
R
F
E
---
D
G
-
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F
K
D
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F
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T
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R
Y
L
F
A
L
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-----
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P
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-----
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N
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R
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R
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A
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F
D
V
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D
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H
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A
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A
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A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
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S
P
E
E
V
E
F
M
D
V
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K
Q
V
F
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T
N
L
I
P
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L
E
H
D
D
A
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R
A
L
M
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M
Q
T
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P
L
I
R
A
Q
A
P
V
V
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L
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E
R
V
V
R
D
S
L
A
A
L
Y
A
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V
A
K
V
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N
R
I
V
V
R
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E
-------
D
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-------
L
V
-------
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R
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L
A
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I
H
I
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Y
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A
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L
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I
T
R
D
I
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L
S
E
A
A
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D
L
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E
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V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
--------------------------
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
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K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
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D
M
P
H
L
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D
G
T
P
V
D
V
I
L
N
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L
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V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
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M
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V
W
A
L
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A
Y
G
A
A
H
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L
Q
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M
L
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L
K
S
D
D
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E
G
R
N
A
A
Y
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A
I
I
K
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L
V
K
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A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
------------------------------
39
PsiBlast_CBE
80.10
49%
-62
- C6 -
3AOI
2
RPOB_THET8
M:
[6-1112]
----------------------------------
F
G
R
I
R
E
V
I
P
L
P
P
L
T
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I
Q
V
E
S
Y
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P
E
K
R
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N
V
----------
G
I
Q
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A
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T
F
P
I
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E
---------
G
L
V
L
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-------
H
K
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-------
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L
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--
T
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--
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G
V
V
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N
-
K
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P
L
V
L
L
L
R
V
L
G
Y
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Q
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T
L
A
-
R
E
L
--------------------------------------------------------
G
A
Y
G
--------
E
L
-------------------------------------------------------------
V
Q
G
L
-------------------------------
M
-
D
E
S
V
F
A
M
R
P
E
E
A
L
--------------------------------------------------------------------------
I
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L
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L
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A
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G
D
I
L
V
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T
----------------------
A
R
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V
K
D
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S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
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D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
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V
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Y
V
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Q
K
R
K
L
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V
A
K
I
L
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D
M
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V
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L
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L
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L
G
Q
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L
E
T
H
L
G
L
A
G
Y
F
L
G
Q
R
----------------------------------------------------------------------------------
Y
I
S
P
I
F
D
G
A
K
E
P
E
I
K
E
L
L
A
--------------
Q
A
F
E
VYFGKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
KLGLVTPGKTPEEQLKELFLQ
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
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D
K
M
H
A
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S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
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F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
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A
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A
I
I
K
G
E
D
V
P
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L
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A
L
A
L
D
V
Q
T
L
D
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K
D
N
P
V
D
I
F
------------------------------
88
PsiBlast_CBE
69.54
58%
-58
- C6 -
4MEX
1
RPOB_ECOLI
I:
[350-937]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
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P
P
T
R
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A
A
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S
L
F
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L
F
F
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D
R
Y
D
L
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A
V
G
R
M
K
F
N
R
S
L
---
L
-
R
----
E
E
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---
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
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A
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N
N
P
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V
N
-------
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D
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-------
M
Y
PGEAGID
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
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R
G
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V
L
A
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L
G
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L
A
L
G
Q
N
M
R
V
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F
M
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W
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Y
N
F
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I
L
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L
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N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
69.28
58%
-59
- C6 -
4MEX
1
RPOB_ECOLI
C:
[350-937]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
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A
A
E
S
L
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F
F
S
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D
R
Y
D
L
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A
V
G
R
M
K
F
N
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S
L
---
L
-
R
----
E
E
I
E
---
G
S
G
I
L
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D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
------------
E
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D
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T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
68.80
58%
-58
- C6 -
4YLO
1
RPOB_ECOLI
I:
[350-937]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
---
L
-
R
----
E
E
I
E
---
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
-------
E
D
E
-------
M
Y
PGEAGID
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
68.49
58%
-57
- C6 -
4YLO
1
RPOB_ECOLI
C:
[350-937]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
---
L
-
R
----
E
E
I
E
---
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
-------
E
D
E
-------
M
Y
PGEAGID
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
68.35
58%
-54
- C6 -
4YLN
1
RPOB_ECOLI
I:
[350-937]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
---
L
-
R
----
E
E
I
E
---
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
-------
E
D
E
-------
M
Y
PGEAGID
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
68.28
58%
-61
- C6 -
4YLP
1
RPOB_ECOLI
C:
[350-937]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
---
L
-
R
----
E
E
I
E
---
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
-------
E
D
E
-------
M
Y
PGEAGID
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
68.21
58%
-60
- C6 -
4YLN
1
RPOB_ECOLI
C:
[350-937]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
---
L
-
R
----
E
E
I
E
---
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
-------
E
D
E
-------
M
Y
PGEAGID
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
67.96
58%
-56
- C6 -
4YLP
1
RPOB_ECOLI
I:
[350-937]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
---
L
-
R
----
E
E
I
E
---
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
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T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
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N
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Y
G
F
L
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P
Y
R
K
V
T
D
G
V
V
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D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
-------
E
D
E
-------
M
Y
PGEAGID
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
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S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
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T
Q
L
T
P
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K
L
L
R
A
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F
G
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A
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V
K
D
S
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L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
65.01
58%
-56
- C6 -
4S20
1
RPOB_ECOLI
C:
[350-970]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------
L
-
R
V
D
-
P
T
N
D
R
L
S
A
L
--------------------------------------------------------------------------
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
---
L
-
R
----
E
E
I
E
---
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
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L
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R
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A
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L
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D
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M
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M
I
N
A
K
P
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A
A
V
K
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F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
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I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
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A
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F
E
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R
D
V
H
P
T
H
Y
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R
V
C
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L
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Y
A
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A
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V
I
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V
N
-------------------GID----
I
Y
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L
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Y
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G
T
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I
D
V
Q
V
F
T
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------