@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0668: (2016-04-24 )
MLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERKAVEDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGEREMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVIRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPASGDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPPVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITIVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQVKVRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRNIAVQPTEEARAAAYTIPSYEDQYYSPDFGAATGAAVPLDDYGYSDYR
Atome Classification :
(37 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250...-....260.......270.......280.......290.-......300.......310.......320.......330.......340.......350.......360.......370.......380.......390...-.-...400.......410.......420.......430.......440.......450.......460.......470.......480--........490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590----------...---------......600-........610--.-........620.......630.......640.......650.-......660..---------------------.....670..--------------.....680.--......690.......700.......710.---......720.......730.......740.......750.......760.......770.......780.......790....---------------...800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......---900.......-----910.......920.......930.-......940.......950....----...960.......970.......980.......990.......1000......1010......1020........1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260..--....1270..----....1280......1290......1300......1310...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLDVN
F
F
D
E
L
R
I
GLA
T
A
E
D
I
R
QWSYGEVKKPETINYRTLKPEKDG
L
F
C
E
K
IFGPTRDW
E
C
YCGKY
K
R
V
R
F
K
G
I
I
C
E
RCGV
E
V
T
R
A
K
V
R
R
E
RMG
H
I
E
LAAP
V
T
H
I
W
Y
FKGV
P
S
R
L
G
Y
L
LDL
A
P
K
D
L
E
K
I
I
Y
F
A
A
Y
V
I
T
S
V
D
E
E
M
R
H
N
E
L
S
T
L
E
A
E
M
A
V
E
R
K
AVEDQRD
G
E
L
E
A
R
A
Q
K
L
E
A
D
L
A
E
L
EAEGAK
A
D
A
R
R
KVRDG
G
E
R
E
M
R
Q
I
R
D
R
A
Q
R
E
L
D
R
L
E
D
I
W
S
T
F
T
KLA
P
K
Q
L
IV
D
E
N
L
Y
R
E
L
V
D
R
Y
G
E
Y
FTGA-M
G
A
E
S
I
Q
K
L
I
E
NFDID
A
E
A
E
S
L
R
D
V
I
RNGK
G
Q
K
K
L
R
A
L
-
K
R
L
K
V
V
A
A
F
Q
QSGNSP
M
G
M
V
L
DAVPVIPPEL
R
P
M
V
Q
LDGGRFATS
D
L
N
D
L
Y
R
R
V
INR
N
N
R
L
K
R
L
I
DLGA
P
E
I
I
VN
N
E
K
R
M
L
Q
E
S
V
D
A
L
FDNGRRGRPVTGPG-N-R
P
L
K
S
L
S
D
L
L
KGKQ
G
R
F
R
Q
N
L
LGKRVDYSG
R
S
V
I
V
VGP
Q
L
K
L
HQCGL
P
K
L
M
A
L
E
L
F
K
P
F
V
M
K
R
L
V
DL
N
H
A
Q
N
I
K
S
A
K
R
M
V
E
R
QR
P
---
Q
V
W
D
V
L
E
E
V
I
A
EH
P
V
LLNRAP
T
L
H
R
L
G
I
Q
A
FE
P
M
LVEG
K
A
I
Q
L
H
P
L
V
C
E
A
FNADFDGD
Q
M
A
V
H
LPLSAEAQA
E
A
R
I
L
M
L
SSNNILSPASGRPLAM
P
R
L
D
M
V
T
G
L
Y
Y
L
T
T------------EVP---------GDTGEYQP--ASGDHPETG----V-YS
S
P
A
E
A
I
M
A
ADR
G
V
L
S
V
R
A
K
I
K
V
R
L
T
QLRPP
V
E
I
E
A
E
LFGH-SGWQPGD
A
W
M
A
---------------------
E
T
T
L
G
R
V
M
F
N
--------------
E
LLPLGY
P
F
--
V
N
K
Q
M
H
K
K
V
Q
A
A
I
I
N
D
L
A
E
RY
P
M
I
V
V
A
Q
T
V
---
D
KLKDA
G
F
Y
W
ATRS
G
V
T
V
S
M
A
D
VLVPP
R
K
K
E
I
L
D
H
Y
E
E
R
A
D
K
V
E
K
Q
F
Q
RGALN
H
D
E
R
N
E
A
L
V
E
I
W
K
E
A
T
D
E
V
G
Q
A
L
R
E
HYPDD---------------N
P
I
I
T
I
VDSGATGNF
T
Q
T
R
T
LAGMKG
L
V
TNPKGEFIPR
P
V
K
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
NTHGARKG
L
A
D
T
A
L
RTADS
G
Y
L
T
R
R
L
V
DVSQ
D
V
I
V
REHDCQTER
G
I
V
V
---
E
L
A
E
RAPDG
T
-----
L
I
RDPYIE
T
S
A
Y
A
R
TLGT
D
A
V
D
E
A-GN
V
I
V
ERGQDLG
D
P
E
I
D
A
L
L
A
AG----
I
T
Q
V
K
V
R
S
V
L
TCATSTG
V
C
A
T
CYGRSMATG
K
L
VDI
G
E
A
V
G
I
V
A
A
Q
SIGEPGT
Q
L
T
M
R
T
F
HQGGVG--EDITG
G
L
P
R
V
Q
E
L
F
E
ARVPRGKAPIADV
T
G
R
V
R
LEDG
E
R
F
Y
K
I
T
I
V
PDDGGE
E
V
V
Y
D
K
I
S
K
R
Q
R
L
R
V
F
KHEDGSERVLSDGD
H
V
E
V
G
Q
Q
L
M
EGSA
D
P
H
E
V
L
RVQGP
R
E
V
Q
I
H
L
V
R
E
V
Q
E
V
Y
R
AQGVS
I
H
D
K
H
I
E
V
I
V
R
Q
M
L
R
R
V
T
I
IDSGSTEFLP
G
S
LI
D
R
A
EFEAEN
R
R
V
V
AEGGEPAAGR
P
V
L
M
G
I
T
KASLAT
D
S
W
L
S
A
A
S
F
Q
E
T
T
R
V
L
T
D
AAINCRSDKLNGLKEN
V
I
I
G
K
LIPAGTGI
N
--
R
Y
R
N
I
A
VQPT----EEAR
A
A
A
Y
TIPSYEDQYYSPDFGAATGAAVPLDDYGYSDYR
16
PsiBlast_PDB
84.05
50%
-74
- C9 -
4G7H
6
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
Q
R
D
IK
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
G
R
L
K
Y
-
V
F
A
N
P
D
E
A
L
L
A
V
A
H
GIVDLQ
D
V
V
T
V
R
Y
MG
K
R
L
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
ED
E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
---
P
L
F
Q
--
P
D
E
V
TR
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
--
E
V
-
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
--------------
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
T
E
E
--
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----------------------------------
28
PsiBlast_CBE
83.91
50%
-76
- C9 -
4OIQ
7
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
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L
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L
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Y
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Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
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A
T
P
E
E
A
L
A
A
H
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G
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V
A
L
N
A
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V
------
A
G
R
E
T
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V
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L
K
Y
-
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P
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D
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-----
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---
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V
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N
F
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N
P
L
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M
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G
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---
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--
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R
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V
--
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L
G
V
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L
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E
G
R
Y
L
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M
D
D
V
H
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L
I
K
A
A
E
A
GE
I
Q
E
V
P
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R
S
P
L
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Q
T
R
Y
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Q
K
C
Y
G
Y
D
L
S
M
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V
S
I
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V
G
I
V
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T
Q
L
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-------------
I
T
Q
G
L
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I
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L
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A
R
R
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--
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L
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F
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L
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R
L
-----------
L
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D
G
D
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A
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Q
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L
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R
G
A
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Q
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L
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Y
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Q
K
V
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V
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L
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H
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R
Q
M
M
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Y
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E
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T
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L
L
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G
Q
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L
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W
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V
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A
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L
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K
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P
L
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A
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A
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K
T
L
K
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E
A
R
K
E
A
----------------------------------
21
PsiBlast_CBE
83.70
50%
-76
- C9 -
5E18
5
?
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
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A
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L
L
K
E
L
D
L
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A
L
E
K
E
L
L
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E
M
K
H
P
S
R
A
R
R
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R
-
K
R
L
E
V
V
R
A
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L
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S
G
N
R
P
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W
M
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L
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P
V
L
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D
L
R
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V
D
G
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A
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L
L
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G
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I
V
V
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------------
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R
K
---------
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G
-------------
A
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----
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A
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A
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------
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D
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T
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--------------
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Q
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L
-----------
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L
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V
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L
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D
K
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R
Q
M
M
K
Y
V
E
V
T
D
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L
L
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Q
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L
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V
E
A
L
N
E
R
L
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K
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P
L
L
M
G
V
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S
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A
A
S
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N
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A
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L
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A
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E
E
A
R
K
E
A
----------------------------------
34
PsiBlast_CBE
83.67
50%
-77
- C9 -
4G7O
6
RPOC_THET8
N:
[435-1498]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
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S
Y
D
I
D
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R
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L
L
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----
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RIVAEAVEDEKVAW
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R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
-------
V
A
GA
A
D
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
T
E
E
--
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
LKAI
E
E
A
--------------------------------------
27
PsiBlast_CBE
83.66
50%
-76
- C9 -
4OIR
7
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
Q
R
D
IK
D
E
V
W
D
A
L
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H
G
K
V
V
L
L
N
R
A
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L
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R
L
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A
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Q
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V
L
V
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G
Q
S
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Q
L
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L
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N
A
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D
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M
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N
L
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G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
G
R
L
K
Y
-
V
F
A
N
P
D
E
A
L
L
A
V
A
H
GIVDLQ
D
V
V
T
V
R
Y
MGKRL
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
ED
E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
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T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
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R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
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A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
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Q
K
P
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P
V
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S
F
R
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L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
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A
D
C
G
T
T
N
Y
I
S
V
---
P
L
F
Q
--
P
D
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V
TR
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
--
E
V
-
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
---------------
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
T
E
E
--
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
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T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----------------------------------
20
PsiBlast_PDB
83.53
50%
-75
- C9 -
4OIN
7
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
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R
M
L
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R
D
IK
D
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W
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A
L
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V
L
L
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A
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N
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D
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M
A
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V
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L
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F
A
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A
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Q
M
L
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A
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N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
G
R
L
K
Y
-
V
F
A
N
P
D
E
A
L
L
A
V
A
H
GIVDLQ
D
V
V
T
V
R
Y
MGKRL
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
ED
E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
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T
F
E
V
P
V
R
S
S
F
R
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L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
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S
G
Y
L
T
R
K
L
V
D
V
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H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
---
P
L
F
Q
--
P
D
E
V
TR
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
--
E
V
-
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
---------------
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
T
E
E
--
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----------------------------------
22
PsiBlast_CBE
83.43
50%
-76
- C9 -
5E17
5
?
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
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Q
------------
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R
K
---------
E
K
K
G
-------------
A
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----
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A
L
A
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A
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------
A
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R
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-
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-----
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---
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F
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N
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P
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---
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E
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--
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L
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R
Y
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S
M
D
D
V
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L
L
I
K
A
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GE
I
Q
E
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R
S
P
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Q
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--------------
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Q
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-----------
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E
A
R
K
E
A
----------------------------------
35
PsiBlast_CBE
83.41
50%
-75
- C9 -
4G7H
3
RPOC_THET8
N:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
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S
Y
D
I
D
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R
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L
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I
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---------
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-------------
A
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----
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------
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VAHGIVDLQDVVTVRYMGKRL
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L
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A
RIVAEAVEDEKVAW
E
L
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Q
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Q
--
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---
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--------------
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A
R
K
E
A
----------------------------------
29
PsiBlast_CBE
83.41
50%
-76
- C9 -
4OIP
9
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
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S
Y
D
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D
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R
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--------------
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G
L
P
R
V
I
E
L
F
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A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
T
E
E
--
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
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A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
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V
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Y
L
V
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E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
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A
L
S
T
K
S
W
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S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----------------------------------
26
PsiBlast_CBE
83.26
50%
-75
- C9 -
4Q5S
5
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
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Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
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L
E
A
V
P
V
L
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P
D
L
R
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Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
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I
I
I
R
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M
L
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A
L
L
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G
R
R
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V
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N
P
G
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D
-
R
P
L
R
S
L
T
D
I
L
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K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
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Q
L
K
L
H
Q
C
G
L
P
K
R
M
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L
E
L
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K
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F
L
L
K
K
M
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G
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N
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T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
G
R
L
K
Y
-
V
F
A
N
P
D
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A
L
L
A
V
A
H
GIVDLQ
D
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V
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Y
MGKRL
E
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S
P
G
R
I
L
F
A
R
I
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A
V
ED
E
K
V
A
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E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
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T
A
R
L
L
---
D
A
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M
G
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L
W
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E
T
T
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N
F
E
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YPF------------
N
P
L
Y
V
M
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S
G
A
R
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P
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Y
L
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L
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Y
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---
P
L
F
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--
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TRSLR
L
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R
A
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A
G
L
Y
G
R
V
L
A
R
E
V
--
E
V
-
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
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R
S
P
L
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C
Q
T
R
Y
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V
C
Q
K
C
Y
G
Y
D
L
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G
E
A
V
G
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A
Q
S
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G
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P
G
T
Q
L
T
M
---------------
Q
G
L
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R
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I
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L
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A
R
R
P
K
A
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A
V
I
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G
V
V
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I
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E
T
E
E
--
K
L
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V
F
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E
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F
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K
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Y
-
K
L
P
K
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A
R
L
-----------
L
V
K
D
G
D
Y
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A
G
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P
L
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R
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D
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L
L
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K
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P
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A
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Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
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K
T
P
V
A
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K
P
L
L
M
G
V
T
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S
A
L
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T
K
S
W
L
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A
A
S
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N
T
T
H
V
L
T
E
A
A
I
A
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K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
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A
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G
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D
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V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----------------------------------
30
PsiBlast_CBE
83.10
50%
-76
- C9 -
4OIO
7
RPOC_THET8
D:
[435-1498]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
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Q
L
L
K
E
L
D
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L
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E
L
L
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K
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R
A
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R
-
K
R
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L
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W
M
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V
D
G
G
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N
D
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R
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N
R
N
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R
L
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K
L
L
A
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G
A
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M
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A
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A
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R
R
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N
P
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D
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R
P
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L
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K
Q
G
R
F
R
Q
N
L
L
G
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R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
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L
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Q
C
G
L
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M
A
L
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L
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L
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L
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Y
I
T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
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Y
-
V
F
A
N
P
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A
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A
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GIVDLQ
D
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V
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V
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Y
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K
R
L
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T
S
P
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A
R
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V
A
E
A
V
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E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
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L
-----
R
L
G
M
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T
A
R
L
L
---
D
A
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P
---T
R
S
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L
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R
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A
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L
Y
G
R
V
L
A
R
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V
--
E
V
-
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
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R
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P
L
T
C
Q
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R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
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A
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E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
--------------
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
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G
V
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R
I
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--
K
L
S
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F
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E
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F
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K
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Y
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K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
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R
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A
I
D
P
H
Q
L
L
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A
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G
P
E
A
V
E
R
Y
L
V
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E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
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E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
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R
L
L
E
G
Q
V
L
E
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W
D
V
E
A
L
N
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R
L
I
A
E
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K
T
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V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
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V
L
T
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A
A
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A
G
K
K
D
E
L
I
G
L
K
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N
V
I
L
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L
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P
A
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T
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D
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R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
--------------------------------------
17
PsiBlast_PDB
83.08
50%
-77
- C9 -
4G7O
6
RPOC_THET8
D:
[435-1498]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
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L
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A
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R
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R
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D
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R
P
L
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L
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L
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Q
G
R
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L
L
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D
Y
S
G
R
S
V
I
V
V
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L
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C
G
L
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L
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L
G
L
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Y
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T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
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A
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V
------
A
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-
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---
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F
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N
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S
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P
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---
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G
R
V
L
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--
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V
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L
G
V
R
L
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G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
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GE
I
Q
E
V
P
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R
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P
L
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--------------
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Q
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L
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L
-----------
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L
K
A
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E
E
A
--------------------------------------
33
PsiBlast_CBE
82.60
50%
-74
- C9 -
4G7Z
4
RPOC_THET8
N:
[435-1498]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
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Y
D
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D
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R
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Q
------------
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K
---------
E
K
K
G
-------------
A
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----
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A
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P
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A
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------
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-
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VAHGIVDLQDVVTVRYMGKRL
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L
F
A
RIVAEAVEDEKVAW
E
L
I
Q
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D
V
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Q
--
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V
Y
Q
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E
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A
--------------------------------------
18
PsiBlast_PDB
82.59
50%
-73
- C9 -
4G7Z
4
RPOC_THET8
D:
[435-1498]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
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Y
D
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D
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A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
--------------------------------------
12
PsiBlast_PDB
81.52
50%
-71
- C9 -
2PPB
8
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
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M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
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K
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M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
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D
-
R
P
L
R
S
L
T
D
I
L
S
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K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
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M
A
L
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L
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P
F
L
L
K
K
M
E
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G
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N
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L
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A
R
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Q
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L
S
A
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N
L
L
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P
A
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G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
G
R
L
K
Y
-
V
F
A
N
P
D
E
A
L
L
A
VAHGIVDLQDVVTVRYMGKRL
E
T
S
P
G
R
I
L
F
A
RIVAEAVEDEKVAW
E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
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Q
Y
L
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L
L
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Q
A
Y
E
M
G
F
L
T
D
R
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R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
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P
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R
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F
R
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L
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H
G
A
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K
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R
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A
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Y
L
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R
K
L
V
D
V
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I
V
V
R
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A
D
C
G
T
T
N
Y
I
S
V
---
P
L
F
Q
--
P
D
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TRSLR
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
--
E
V
-
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
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I
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L
T
M
R
T
F
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-------
D
I
T
Q
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L
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I
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L
F
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A
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V
V
R
I
E
E
T
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--
K
L
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S
E
G
F
S
K
E
Y
-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
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A
G
Q
P
L
T
R
G
A
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D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
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A
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K
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A
W
K
P
L
L
M
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L
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T
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W
L
S
A
A
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V
L
T
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A
A
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A
G
K
K
D
E
L
I
G
L
K
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N
V
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L
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P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
LKAI
E
E
A
R
K
E
A
----------------------------------
46
PsiBlast_CBE
81.31
50%
-71
- C9 -
2A6H
3
RPOC_THET8
N:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
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L
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G
N
R
P
E
W
M
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V
L
P
P
D
L
R
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M
V
Q
V
D
G
G
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A
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L
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D
L
Y
R
R
L
I
N
R
N
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R
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K
L
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A
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I
I
I
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A
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L
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G
R
R
G
A
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V
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N
P
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R
P
L
R
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L
T
D
I
L
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K
Q
G
R
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N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
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L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
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F
L
L
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K
M
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G
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A
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L
A
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P
S
R
D
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I
L
G
L
Y
Y
I
T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
G
R
L
K
Y
-
V
F
A
N
P
D
E
A
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L
A
VAHGIVDLQDVVTVRYMGKRL
E
T
S
P
G
R
I
L
F
A
RIVAEAVEDEKVAW
E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
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K
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Y
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F
T
F
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G
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W
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E
T
T
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V
T
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A
V
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K
N
F
E
E
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YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
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P
Q
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L
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Y
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---
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L
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--
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TRSLR
L
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A
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L
Y
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V
L
A
R
E
V
--
E
V
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L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
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A
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V
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A
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S
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G
T
Q
L
T
M
R
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D
I
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Q
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L
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F
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A
R
R
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A
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A
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R
I
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E
T
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--
K
L
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V
F
V
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E
G
F
S
K
E
Y
-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
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R
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A
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D
P
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Q
L
L
E
A
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G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
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K
T
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A
W
K
P
L
L
M
G
V
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A
L
S
T
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S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
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A
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K
K
D
E
L
I
G
L
K
E
N
V
I
L
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R
L
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A
G
T
G
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D
FV
R
F
T
Q
V
V
D
Q
K
T
LKAI
E
E
A
R
K
E
A
----------------------------------
41
PsiBlast_CBE
81.25
50%
-72
- C9 -
2PPB
9
RPOC_THET8
N:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
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A
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Q
L
L
K
E
L
D
L
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A
L
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K
E
L
L
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M
K
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S
R
A
R
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A
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A
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-
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R
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R
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L
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Q
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L
L
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D
Y
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G
R
S
V
I
V
V
G
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L
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L
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Q
C
G
L
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M
A
L
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L
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A
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Y
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------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
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A
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P
E
E
A
L
A
A
H
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R
G
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A
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N
A
P
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V
------
A
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V
G
R
L
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Y
-
V
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VAHGIVDLQDVVTVRYMGKRL
E
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RIVAEAVEDEKVAW
E
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---
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---
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R
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A
----------------------------------
10
PsiBlast_PDB
81.23
50%
-72
- C9 -
2O5I
6
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
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L
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---------
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K
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-------------
A
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----
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------
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VAHGIVDLQDVVTVRYMGKRL
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RIVAEAVEDEKVAW
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---
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E
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A
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A
----------------------------------
7
PsiBlast_PDB
81.11
50%
-70
- C9 -
2A6H
3
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
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VAHGIVDLQDVVTVRYMGKRL
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Q
K
T
LKAI
E
E
A
R
K
E
A
----------------------------------
19
PsiBlast_PDB
80.79
50%
-72
- C9 -
3WOD
1
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
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M
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Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
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A
V
D
A
L
L
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N
G
R
R
G
A
P
V
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N
P
G
S
D
-
R
P
L
R
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L
T
D
I
L
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K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
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I
V
V
G
P
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L
K
L
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Q
C
G
L
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L
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K
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V
L
L
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L
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L
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A
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N
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V
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L
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F
A
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A
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Q
M
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H
N
L
L
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A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
G
R
L
K
Y
-
V
F
A
N
P
D
E
A
L
L
A
V
A
H
GIVDLQ
D
V
V
T
V
R
Y
MGKRL
E
T
S
P
G
R
I
L
F
A
R
I
V
A
E
A
V
ED
E
K
V
A
W
E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
G
F
T
F
S
T
T
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G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
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A
D
R
K
L
L
Q
I
E
Q
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Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
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L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
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L
T
V
L
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Y
F
I
S
S
H
G
A
R
K
G
G
A
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T
A
L
R
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A
D
S
G
Y
L
T
R
K
L
V
D
V
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H
E
I
V
V
R
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A
D
C
G
T
T
N
Y
I
S
V
---
P
L
F
Q
--
P
D
E
V
TR
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
--
E
V
-
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
GE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
----------------
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
T
E
E
--
K
L
S
V
F
V
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E
G
F
S
K
E
Y
-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----------------------------------
43
PsiBlast_CBE
80.61
50%
-73
- C9 -
2O5I
5
RPOC_THET8
N:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
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K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
-
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
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P
F
L
L
K
K
M
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G
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A
P
N
V
K
A
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R
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L
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IKD
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L
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V
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L
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F
A
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A
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A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
G
R
L
K
Y
-
V
F
A
N
P
D
E
A
L
L
A
VAHGIVDLQDVVTVRYMGKRL
E
T
S
P
G
R
I
L
F
A
RIVAEAVEDEKVAW
E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
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F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
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K
Q
Y
L
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E
A
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K
L
L
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Y
E
M
G
F
L
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D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
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N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
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R
Q
L
C
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Q
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L
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V
L
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F
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H
G
A
R
K
G
G
A
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T
A
L
R
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L
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L
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H
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C
G
T
T
N
Y
I
S
V
---
P
L
F
Q
--
P
D
E
V
TRSLR
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
--
E
V
-
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
EAGE
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
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P
V
S
I
G
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A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
------------------
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
T
E
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--
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
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A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
LKAI
E
E
A
R
K
E
A
----------------------------------
39
PsiBlast_CBE
80.31
50%
-72
- C9 -
3AOI
5
RPOC_THET8
I:
[435-1499]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
------------
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
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I
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R
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K
R
M
L
Q
E
A
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D
A
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N
G
R
R
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A
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V
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N
P
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S
D
-
R
P
L
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S
L
T
D
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K
Q
G
R
F
R
Q
N
L
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R
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D
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R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
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M
A
L
E
L
F
K
P
F
L
L
K
K
M
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A
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N
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A
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L
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------------
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R
K
---------
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K
K
G
-------------
A
G
----
L
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A
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A
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A
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------
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Y
-
V
F
A
N
P
D
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A
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VAHGIVDLQDVVTVRYMGKRL
E
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R
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L
F
A
RIVAEAVEDEKVAW
E
L
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Q
L
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V
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Q
--
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-----
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M
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A
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L
L
---
D
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F
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N
P
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A
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G
A
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L
C
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---
P
L
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--
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TRSLR
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A
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L
Y
G
R
V
L
A
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--
E
V
-
L
G
V
R
L
E
E
G
R
Y
L
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M
D
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V
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A
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EAGE
I
Q
E
V
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-------------
T
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--
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K
L
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K
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L
-----------
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M
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L
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W
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A
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V
L
T
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A
A
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A
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K
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D
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N
V
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L
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L
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P
A
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T
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S
D
FV
R
F
T
Q
V
V
D
Q
K
T
LKAI
E
E
A
R
-------------------------------------
15
PsiBlast_PDB
79.81
50%
-72
- C9 -
3AOI
3
RPOC_THET8
D:
[435-1499]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
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Q
L
L
K
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L
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L
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A
L
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L
L
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M
K
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P
S
R
A
R
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A
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-
K
R
L
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V
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L
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P
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W
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P
V
L
P
P
D
L
R
P
-----------
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D
L
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L
G
L
Y
Y
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Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
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G
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V
A
L
N
A
P
I
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V
------
A
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V
G
R
L
K
Y
-
V
F
A
N
P
D
E
A
L
L
A
VAHGIVDLQDVVTVRYMGKRL
E
T
S
P
G
R
I
L
F
A
RIVAEAVEDEKVAW
E
L
I
Q
L
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
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-----
R
L
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M
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K
T
A
R
L
L
---
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V
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A
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F
K
N
F
E
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YPF------------
N
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L
Y
V
M
A
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S
G
A
R
G
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P
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L
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---
P
L
F
Q
--
P
D
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TRSLR
L
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A
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L
Y
G
R
V
L
A
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--
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L
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L
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G
R
Y
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M
D
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V
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I
Q
E
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R
S
P
L
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-------------
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G
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L
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Q
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R
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L
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A
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A
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K
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L
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A
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T
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FV
R
F
T
Q
V
V
D
Q
K
T
LKAI
E
E
A
R
-------------------------------------
38
PsiBlast_CBE
79.46
50%
-71
- C9 -
3AOI
2
RPOC_THET8
N:
[435-1499]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
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Y
D
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D
A
R
M
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L
L
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A
L
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S
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A
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A
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L
P
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L
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L
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L
G
L
Y
Y
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Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
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A
L
N
A
P
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V
------
A
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G
R
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Y
-
V
F
A
N
P
D
E
A
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VAHGIVDLQDVVTVRYMGKRL
E
T
S
P
G
R
I
L
F
A
RIVAEAVEDEKVAW
E
L
I
Q
L
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V
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Q
--
E
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L
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Q
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M
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T
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R
L
L
---
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A
V
F
K
N
F
E
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YPF------------
N
P
L
Y
V
M
A
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S
G
A
R
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P
Q
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Y
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---
P
L
F
Q
--
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TRSLR
L
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A
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L
Y
G
R
V
L
A
R
E
V
--
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L
G
V
R
L
E
E
G
R
Y
L
S
M
D
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V
H
L
L
I
K
A
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I
Q
E
V
P
V
R
S
P
L
T
C
Q
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R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
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I
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A
V
G
I
V
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A
Q
S
I
G
E
P
G
T
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L
T
-------------
D
I
T
Q
G
L
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R
V
I
E
L
F
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A
R
R
P
K
A
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D
G
V
V
R
I
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--
K
L
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V
F
V
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S
E
G
F
S
K
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-
K
L
P
K
E
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
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G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
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G
K
T
P
V
A
W
K
P
L
L
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V
T
K
S
A
L
S
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K
S
W
L
S
A
A
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F
Q
N
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H
V
L
T
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A
A
I
A
G
K
K
D
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L
I
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L
K
E
N
V
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L
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R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
LKAI
E
E
A
R
-------------------------------------
42
PsiBlast_CBE
78.06
50%
-71
- C9 -
2O5J
7
RPOC_THET8
N:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
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A
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Q
L
L
K
E
L
D
L
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A
L
E
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E
L
L
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M
K
H
P
S
R
A
R
R
A
K
A
R
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K
R
L
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V
R
A
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L
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G
N
R
P
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R
L
I
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L
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R
R
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V
T
N
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A
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A
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Q
M
L
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A
H
N
L
L
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A
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G
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P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
------
A
G
R
E
T
S
V
G
R
L
K
Y
-
V
F
A
N
P
D
E
A
L
L
A
VAHGIVDLQDVVTVRYMGKRL
E
T
S
P
G
R
I
L
F
A
RIVAEAVEDEKVAW
E
L
I
Q
L
D
V
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Q
--
E
K
N
S
L
K
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L
V
Y
Q
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L
-----
R
L
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M
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---
D
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W
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T
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K
V
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V
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K
N
F
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YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
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D
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Y
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---
P
L
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Q
--
P
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TRSLR
L
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R
A
D
I
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A
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L
Y
G
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--
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I
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I
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L
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R
V
I
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L
F
E
A
R
R
P
K
A
K
-----------------------------------------------------------------------
A
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D
P
H
Q
L
L
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A
K
G
P
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A
V
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R
Y
L
V
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Q
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V
D
Q
K
T
LKAI
E
E
A
R
K
E
A
----------------------------------
11
PsiBlast_PDB
77.55
50%
-72
- C9 -
2O5J
7
RPOC_THET8
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
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S
Y
D
I
D
A
R
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L
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Y
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Q
------------
V
R
K
---------
E
K
K
G
-------------
A
G
----
L
E
F
A
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P
E
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A
L
A
A
H
E
R
G
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V
A
L
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A
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------
A
G
R
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S
V
G
R
L
K
Y
-
V
F
A
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P
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A
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VAHGIVDLQDVVTVRYMGKRL
E
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S
P
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F
A
RIVAEAVEDEKVAW
E
L
I
Q
L
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V
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Q
--
E
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L
K
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Q
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-----
R
L
G
M
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---
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YPF------------
N
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L
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N
Y
I
S
V
---
P
L
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Q
--
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TRSLR
L
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R
A
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A
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L
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--
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L
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A
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L
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R
V
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L
F
E
A
R
R
P
K
A
K
-----------------------------------------------------------------------
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
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E
I
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Y
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V
D
Q
K
T
LKAI
E
E
A
R
K
E
A
----------------------------------
25
PsiBlast_CBE
75.83
50%
-68
- C9 -
4WQS
3
RPOC_THET8
N:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
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S
Y
D
I
D
A
R
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A
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L
L
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L
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A
L
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L
L
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L
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------------
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R
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---------
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K
K
G
-------------
A
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----
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A
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A
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VAHGIVDLQDVVTVRYMGKRL
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RIVAEAVEDEKVAW
E
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Q
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---
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N
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P
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Q
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--------------------
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-------------
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-----------
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E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
K
T
LKAI
E
E
A
R
K
E
A
----------------------------------
62
PsiBlast_CBE
73.08
50%
-71
- C9 -
4XLN
3
?
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
E
L
L
K
E
L
D
L
E
K
L
E
R
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
V
I
D
N
G
R
R
G
S
P
V
T
N
P
G
-
S
E
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
A
F
A
P
N
V
K
A
A
R
R
M
L
E
R
Q
R
D
IKD
E
V
W
D
A
L
E
E
V
I
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G
K
V
V
L
L
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R
A
P
T
L
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R
L
G
I
Q
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Q
P
V
L
V
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G
Q
S
I
Q
L
H
P
L
V
C
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A
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N
A
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F
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D
Q
M
A
V
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V
P
L
S
S
F
A
Q
A
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A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
VRKEKKGAGMAF
A
T
P
EEALAAYER
G
E
V
A
L
N
A
P
IV
V
A
G
R
E
T
S
V
G
RLKF
V
-
F
A
N
P
D
E
A
L
L
A
V
A
H
G
L
L
D
L
Q
D
V
V
T
V
R
Y
L
G
R
R
L
E
T
S
P
G
R
I
L
F
A
R
I
V
G
E
A
V
G
D
E
K
V
A
---------------------
Q
-----------------------
E
L
I
Q
M
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
G
F
T
L
S
T
T
S
G
I
T
I
G
I
D
D
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V
I
P
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Y
L
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R
K
L
R
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Q
A
Y
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M
G
F
L
T
D
R
E
R
Y
D
Q
V
I
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
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R
G
L
M
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R
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L
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L
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G
G
A
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G
Y
L
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L
V
D
V
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V
V
R
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A
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C
G
T
T
N
Y
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S
V
PLF
Q
M
D
E
V
T
R
T
L
R
-----
L
R
K
R
S
D
I
E
S
G
L
Y
G
R
V
L
A
R
E
V
--
E
A
-
L
G
R
R
L
E
E
G
R
Y
L
S
L
E
D
V
H
F
L
I
K
A
A
EAGE
V
R
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
V
V
A
A
E
S
I
G
E
P
G
T
Q
L
T
M
--------------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
G
E
D
R
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
---
K
L
P
K
D
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
D
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
L
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
V
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
R
T
LKAI
E
E
A
R
K
E
A
----------------------------------
55
PsiBlast_CBE
72.96
50%
-71
- C9 -
4XLR
3
RPOC_THEAQ
J:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
E
L
L
K
E
L
D
L
E
K
L
E
R
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
V
I
D
N
G
R
R
G
S
P
V
T
N
P
G
-
S
E
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
A
F
A
P
N
V
K
A
A
R
R
M
L
E
R
Q
R
D
IKD
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
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Q
P
V
L
V
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Q
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I
Q
L
H
P
L
V
C
E
A
F
N
A
D
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D
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M
A
V
H
V
P
L
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S
F
A
Q
A
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A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
VRKEKKGAGMAF
A
T
P
EEALAAYER
G
E
V
A
L
N
A
P
IV
V
A
G
R
E
T
S
V
G
RLKF
V
-
F
A
N
P
D
E
A
L
L
A
V
A
H
G
L
L
D
L
Q
D
V
V
T
V
R
Y
L
G
R
R
L
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T
S
P
G
R
I
L
F
A
R
I
V
G
E
A
V
G
D
E
K
V
A
---------------------
Q
-----------------------
E
L
I
Q
M
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
G
F
T
L
S
T
T
S
G
I
T
I
G
I
D
D
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V
I
P
E
E
K
Q
R
Y
L
E
E
A
D
R
K
L
R
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Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
V
I
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
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R
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F
R
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L
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L
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Y
F
I
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K
G
G
A
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R
T
A
D
S
G
Y
L
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K
L
V
D
V
A
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I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
PLF
Q
M
D
E
V
T
R
T
L
R
-----
L
R
K
R
S
D
I
E
S
G
L
Y
G
R
V
L
A
R
E
V
--
E
A
-
L
G
R
R
L
E
E
G
R
Y
L
S
L
E
D
V
H
F
L
I
K
A
A
EAGE
V
R
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
V
V
A
A
E
S
I
G
E
P
G
T
Q
L
T
M
--------------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
G
E
D
R
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
---
K
L
P
K
D
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
D
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
L
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
V
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
R
T
LKAI
E
E
A
R
K
E
A
----------------------------------
61
PsiBlast_CBE
72.93
50%
-71
- C9 -
4XLN
3
?
J:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
E
L
L
K
E
L
D
L
E
K
L
E
R
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
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A
V
P
V
L
P
P
D
L
R
P
M
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Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
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I
I
R
N
E
K
R
M
L
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E
A
V
D
A
V
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G
R
R
G
S
P
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N
P
G
-
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L
R
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L
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D
I
L
S
G
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Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
A
F
A
P
N
V
K
A
A
R
R
M
L
E
R
Q
R
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IKD
E
V
W
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L
E
E
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V
V
L
L
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R
A
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L
G
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R
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L
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Y
I
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Q
VRKEKKGAGMAF
A
T
P
EEALAAYER
G
E
V
A
L
N
A
P
IV
V
A
G
R
E
T
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V
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RLKF
V
-
F
A
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P
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A
L
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A
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L
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K
V
A
---------------------
Q
-----------------------
E
L
I
Q
M
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
G
F
T
L
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
Q
R
Y
L
E
E
A
D
R
K
L
R
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
V
I
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
M
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
A
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
PLF
Q
M
D
E
V
T
R
T
L
R
-----
L
R
K
R
S
D
I
E
S
G
L
Y
G
R
V
L
A
R
E
V
--
E
A
-
L
G
R
R
L
E
E
G
R
Y
L
S
L
E
D
V
H
F
L
I
K
A
A
EAGE
V
R
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
V
V
A
A
E
S
I
G
E
P
G
T
Q
L
T
M
--------------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
G
E
D
R
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
---
K
L
P
K
D
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
D
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
L
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
V
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
R
T
LKAI
E
E
A
R
K
E
A
----------------------------------
56
PsiBlast_CBE
72.66
50%
-70
- C9 -
4XLR
3
RPOC_THEAQ
D:
[435-1502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
D
L
V
R
N
V
V
R
V
V
E
S
Y
D
I
D
A
R
M
G
A
E
A
I
Q
E
L
L
K
E
L
D
L
E
K
L
E
R
E
L
L
E
E
M
K
H
P
S
R
A
R
R
A
K
A
R
-
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
V
I
D
N
G
R
R
G
S
P
V
T
N
P
G
-
S
E
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
A
F
A
P
N
V
K
A
A
R
R
M
L
E
R
Q
R
D
IKD
E
V
W
D
A
L
E
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V
I
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G
K
V
V
L
L
N
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A
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L
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L
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L
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A
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A
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L
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L
L
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S
G
E
P
L
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P
S
R
D
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L
G
L
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Y
I
T
Q
VRKEKKGAGMAF
A
T
P
EEALAAYER
G
E
V
A
L
N
A
P
IV
V
A
G
R
E
T
S
V
G
RLKF
V
-
F
A
N
P
D
E
A
L
L
A
V
A
H
G
L
L
D
L
Q
D
V
V
T
V
R
Y
L
G
R
R
L
E
T
S
P
G
R
I
L
F
A
R
I
V
G
E
A
V
G
D
E
K
V
A
---------------------
Q
-----------------------
E
L
I
Q
M
D
V
P
Q
--
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
-----
R
L
G
M
E
K
T
A
R
L
L
---
D
A
L
K
Y
Y
G
F
T
L
S
T
T
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G
I
T
I
G
I
D
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L
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K
L
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F
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D
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V
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Q
L
W
T
E
T
T
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K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
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L
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L
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F
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G
G
A
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L
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L
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L
V
D
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V
V
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N
Y
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V
PLF
Q
M
D
E
V
T
R
T
L
R
-----
L
R
K
R
S
D
I
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S
G
L
Y
G
R
V
L
A
R
E
V
--
E
A
-
L
G
R
R
L
E
E
G
R
Y
L
S
L
E
D
V
H
F
L
I
K
A
A
EAGE
V
R
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
V
V
A
A
E
S
I
G
E
P
G
T
Q
L
T
M
--------------
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
G
E
D
R
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
---
K
L
P
K
D
A
R
L
-----------
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
D
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
L
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
V
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
S
D
FV
R
F
T
Q
V
V
D
Q
R
T
LKAI
E
E
A
R
K
E
A
----------------------------------
70
PsiBlast_CBE
71.80
50%
-78
- C9 -
4YLP
1
RPOC_ECOLI
D:
[156-939]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Q
I
L
T
E
E
Q
Y
L
D
A
L
E
E
F
G
D
E
F
D
A
K
-
M
G
A
E
A
I
Q
A
L
L
K
S
M
D
L
E
Q
E
C
E
Q
L
R
E
E
L
N
E
T
N
S
E
T
K
R
K
K
L
T
K
R
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K
L
L
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G
N
K
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M
I
L
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L
P
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L
P
P
D
L
R
P
L
V
P
L
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
V
I
N
R
N
N
R
L
K
R
L
L
D
L
A
A
P
D
I
I
V
R
N
E
K
R
M
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A
V
D
A
L
L
D
N
G
R
R
G
R
A
I
T
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N
-
K
-
R
P
L
K
S
L
A
D
M
I
K
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
T
V
G
P
Y
L
R
L
H
Q
C
G
L
P
K
K
M
A
L
E
L
F
K
P
F
I
Y
G
K
L
E
L
R
G
L
A
T
T
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K
A
A
K
K
M
V
E
R
E
E
A
---
V
V
W
D
I
L
D
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R
E
H
P
V
L
L
N
R
A
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L
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R
L
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F
E
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L
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K
A
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L
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A
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D
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D
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A
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N
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N
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V
P
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Q
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V
V
L
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L
Y
Y
M
T
R
------------
D
C
V
---------
N
A
K
G
E
G
M
----------------
V
-
L
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P
K
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A
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L
Y
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L
A
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--
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V
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K
-
T
S
-------
L
K
---------------------
D
T
T
V
G
R
A
I
L
W
--------------
M
I
V
P
K
G
L
P
Y
SI
V
N
Q
A
L
G
K
K
A
I
S
K
M
L
N
T
C
---
Y
R
I
L
G
L
K
P
T
V
IFA
D
Q
I
M
Y
T
G
F
A
Y
A
A
R
S
G
A
S
V
G
I
D
D
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V
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K
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S
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A
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L
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T
A
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W
A
A
A
N
D
R
V
S
K
A
M
M
D
N
L
Q
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TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
A
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M
R
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L
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P
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F
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L
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L
Q
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T
H
G
A
R
K
G
L
A
D
T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
---
T
P
V
I
E
G
G
D
--------
V
K
E
P
-
L
R
D
R
V
L
G
R
V
T
A
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P
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N
T
L
L
H
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D
L
L
E
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N
S
----
V
D
A
V
K
V
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C
D
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A
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P
G
T
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R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
71.04
50%
-78
- C9 -
4YLP
1
RPOC_ECOLI
J:
[156-939]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Q
I
L
T
E
E
Q
Y
L
D
A
L
E
E
F
G
D
E
F
D
A
K
-
M
G
A
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A
I
Q
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L
L
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Y
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T
T
I
K
A
A
K
K
M
V
E
R
E
E
A
---
V
V
W
D
I
L
D
E
V
I
R
E
H
P
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
E
P
V
L
I
E
G
K
A
I
Q
L
H
P
L
V
C
A
A
Y
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
T
L
E
A
Q
L
E
A
R
A
L
M
M
S
T
N
N
I
L
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P
A
N
G
E
P
I
I
V
P
S
Q
D
V
V
L
G
L
Y
Y
M
T
R
------------
D
C
V
---------
N
A
K
G
E
G
M
----------------
V
-
L
T
G
P
K
E
A
E
R
L
Y
R
S
G
L
A
S
L
H
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V
K
V
R
I
T
E
Y
E
K
--
D
A
N
G
E
L
V
A
K
-
T
S
-------
L
K
---------------------
D
T
T
V
G
R
A
I
L
W
--------------
M
I
V
P
K
G
L
P
Y
SI
V
N
Q
A
L
G
K
K
A
I
S
K
M
L
N
T
C
---
Y
R
I
L
G
L
K
P
T
V
IFA
D
Q
I
M
Y
T
G
F
A
Y
A
A
R
S
G
A
S
V
G
I
D
D
M
V
I
P
E
K
K
H
E
I
I
S
E
A
E
A
E
V
A
E
I
Q
E
Q
F
Q
S
G
L
V
T
A
G
E
R
Y
N
K
V
I
D
I
W
A
A
A
N
D
R
V
S
K
A
M
M
D
N
L
Q
T
E
TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
A
G
M
R
G
L
M
A
K
P
D
G
S
I
I
E
T
P
I
T
A
N
F
R
E
G
L
N
V
L
Q
Y
F
I
S
T
H
G
A
R
K
G
L
A
D
T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
---
T
P
V
I
E
G
G
D
--------
V
K
E
P
-
L
R
D
R
V
L
G
R
V
T
A
E
D
V
L
K
P
G
T
A
D
I
L
V
P
R
N
T
L
L
H
E
Q
W
C
D
L
L
E
E
N
S
----
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
R
G
H
I
I
N
K
G
E
A
I
G
V
I
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
71.00
50%
-80
- C9 -
4YLN
1
RPOC_ECOLI
D:
[156-939]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Q
I
L
T
E
E
Q
Y
L
D
A
L
E
E
F
G
D
E
F
D
A
K
-
M
G
A
E
A
I
Q
A
L
L
K
S
M
D
L
E
Q
E
C
E
Q
L
R
E
E
L
N
E
T
N
S
E
T
K
R
K
K
L
T
K
R
I
K
L
L
E
A
F
V
Q
S
G
N
K
P
E
W
M
I
L
T
V
L
P
V
L
P
P
D
L
R
P
L
V
P
L
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
V
I
N
R
N
N
R
L
K
R
L
L
D
L
A
A
P
D
I
I
V
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
R
A
I
T
G
S
N
-
K
-
R
P
L
K
S
L
A
D
M
I
K
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
T
V
G
P
Y
L
R
L
H
Q
C
G
L
P
K
K
M
A
L
E
L
F
K
P
F
I
Y
G
K
L
E
L
R
G
L
A
T
T
I
K
A
A
K
K
M
V
E
R
E
E
A
---
V
V
W
D
I
L
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V
I
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H
P
V
L
L
N
R
A
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L
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L
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A
F
E
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V
L
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K
A
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Q
L
H
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C
A
A
Y
N
A
D
F
D
G
D
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M
A
V
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V
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L
T
L
E
A
Q
L
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R
A
L
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M
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T
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N
G
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I
I
V
P
S
Q
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V
V
L
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L
Y
Y
M
T
R
------------
D
C
V
---------
N
A
K
G
E
G
M
----------------
V
-
L
T
G
P
K
E
A
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R
L
Y
R
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G
L
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L
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V
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V
R
I
T
E
Y
E
K
--
D
A
N
G
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L
V
A
K
-
T
S
-------
L
K
---------------------
D
T
T
V
G
R
A
I
L
W
--------------
M
I
V
P
K
G
L
P
Y
SI
V
N
Q
A
L
G
K
K
A
I
S
K
M
L
N
T
C
---
Y
R
I
L
G
L
K
P
T
V
IFA
D
Q
I
M
Y
T
G
F
A
Y
A
A
R
S
G
A
S
V
G
I
D
D
M
V
I
P
E
K
K
H
E
I
I
S
E
A
E
A
E
V
A
E
I
Q
E
Q
F
Q
S
G
L
V
T
A
G
E
R
Y
N
K
V
I
D
I
W
A
A
A
N
D
R
V
S
K
A
M
M
D
N
L
Q
T
E
TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
A
G
M
R
G
L
M
A
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P
D
G
S
I
I
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T
P
I
T
A
N
F
R
E
G
L
N
V
L
Q
Y
F
I
S
T
H
G
A
R
K
G
L
A
D
T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
---
T
P
V
I
E
G
G
D
--------
V
K
E
P
-
L
R
D
R
V
L
G
R
V
T
A
E
D
V
L
K
P
G
T
A
D
I
L
V
P
R
N
T
L
L
H
E
Q
W
C
D
L
L
E
E
N
S
----
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
R
G
H
I
I
N
K
G
E
A
I
G
V
I
A
A
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S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
70.97
50%
-76
- C9 -
4YLO
1
RPOC_ECOLI
D:
[156-939]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Q
I
L
T
E
E
Q
Y
L
D
A
L
E
E
F
G
D
E
F
D
A
K
-
M
G
A
E
A
I
Q
A
L
L
K
S
M
D
L
E
Q
E
C
E
Q
L
R
E
E
L
N
E
T
N
S
E
T
K
R
K
K
L
T
K
R
I
K
L
L
E
A
F
V
Q
S
G
N
K
P
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W
M
I
L
T
V
L
P
V
L
P
P
D
L
R
P
L
V
P
L
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
V
I
N
R
N
N
R
L
K
R
L
L
D
L
A
A
P
D
I
I
V
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N
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K
R
M
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Q
E
A
V
D
A
L
L
D
N
G
R
R
G
R
A
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S
N
-
K
-
R
P
L
K
S
L
A
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M
I
K
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
T
V
G
P
Y
L
R
L
H
Q
C
G
L
P
K
K
M
A
L
E
L
F
K
P
F
I
Y
G
K
L
E
L
R
G
L
A
T
T
I
K
A
A
K
K
M
V
E
R
E
E
A
---
V
V
W
D
I
L
D
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V
I
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E
H
P
V
L
L
N
R
A
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L
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L
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A
F
E
P
V
L
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K
A
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L
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A
A
Y
N
A
D
F
D
G
D
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M
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G
E
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I
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P
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Q
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V
L
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L
Y
Y
M
T
R
------------
D
C
V
---------
N
A
K
G
E
G
M
----------------
V
-
L
T
G
P
K
E
A
E
R
L
Y
R
S
G
L
A
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L
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V
K
V
R
I
T
E
Y
E
K
--
D
A
N
G
E
L
V
A
K
-
T
S
-------
L
K
---------------------
D
T
T
V
G
R
A
I
L
W
--------------
M
I
V
P
K
G
L
P
Y
SI
V
N
Q
A
L
G
K
K
A
I
S
K
M
L
N
T
C
---
Y
R
I
L
G
L
K
P
T
V
IFA
D
Q
I
M
Y
T
G
F
A
Y
A
A
R
S
G
A
S
V
G
I
D
D
M
V
I
P
E
K
K
H
E
I
I
S
E
A
E
A
E
V
A
E
I
Q
E
Q
F
Q
S
G
L
V
T
A
G
E
R
Y
N
K
V
I
D
I
W
A
A
A
N
D
R
V
S
K
A
M
M
D
N
L
Q
T
E
TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
A
G
M
R
G
L
M
A
K
P
D
G
S
I
I
E
T
P
I
T
A
N
F
R
E
G
L
N
V
L
Q
Y
F
I
S
T
H
G
A
R
K
G
L
A
D
T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
---
T
P
V
I
E
G
G
D
--------
V
K
E
P
-
L
R
D
R
V
L
G
R
V
T
A
E
D
V
L
K
P
G
T
A
D
I
L
V
P
R
N
T
L
L
H
E
Q
W
C
D
L
L
E
E
N
S
----
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
R
G
H
I
I
N
K
G
E
A
I
G
V
I
A
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S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
70.84
50%
-80
- C9 -
4YLN
1
RPOC_ECOLI
J:
[156-939]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Q
I
L
T
E
E
Q
Y
L
D
A
L
E
E
F
G
D
E
F
D
A
K
-
M
G
A
E
A
I
Q
A
L
L
K
S
M
D
L
E
Q
E
C
E
Q
L
R
E
E
L
N
E
T
N
S
E
T
K
R
K
K
L
T
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R
I
K
L
L
E
A
F
V
Q
S
G
N
K
P
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M
I
L
T
V
L
P
V
L
P
P
D
L
R
P
L
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P
L
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
V
I
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R
N
N
R
L
K
R
L
L
D
L
A
A
P
D
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M
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Q
E
A
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D
A
L
L
D
N
G
R
R
G
R
A
I
T
G
S
N
-
K
-
R
P
L
K
S
L
A
D
M
I
K
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
T
V
G
P
Y
L
R
L
H
Q
C
G
L
P
K
K
M
A
L
E
L
F
K
P
F
I
Y
G
K
L
E
L
R
G
L
A
T
T
I
K
A
A
K
K
M
V
E
R
E
E
A
---
V
V
W
D
I
L
D
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V
I
R
E
H
P
V
L
L
N
R
A
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G
E
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I
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V
P
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Q
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V
V
L
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L
Y
Y
M
T
R
------------
D
C
V
---------
N
A
K
G
E
G
M
----------------
V
-
L
T
G
P
K
E
A
E
R
L
Y
R
S
G
L
A
S
L
H
A
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V
K
V
R
I
T
E
Y
E
K
--
D
A
N
G
E
L
V
A
K
-
T
S
-------
L
K
---------------------
D
T
T
V
G
R
A
I
L
W
--------------
M
I
V
P
K
G
L
P
Y
SI
V
N
Q
A
L
G
K
K
A
I
S
K
M
L
N
T
C
---
Y
R
I
L
G
L
K
P
T
V
IFA
D
Q
I
M
Y
T
G
F
A
Y
A
A
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G
A
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F
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L
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N
K
V
I
D
I
W
A
A
A
N
D
R
V
S
K
A
M
M
D
N
L
Q
T
E
TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
A
G
M
R
G
L
M
A
K
P
D
G
S
I
I
E
T
P
I
T
A
N
F
R
E
G
L
N
V
L
Q
Y
F
I
S
T
H
G
A
R
K
G
L
A
D
T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
---
T
P
V
I
E
G
G
D
--------
V
K
E
P
-
L
R
D
R
V
L
G
R
V
T
A
E
D
V
L
K
P
G
T
A
D
I
L
V
P
R
N
T
L
L
H
E
Q
W
C
D
L
L
E
E
N
S
----
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
R
G
H
I
I
N
K
G
E
A
I
G
V
I
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
70.41
50%
-76
- C9 -
4YLO
1
RPOC_ECOLI
J:
[156-939]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Q
I
L
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-
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---
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---------
N
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----------------
V
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L
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---------------------
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--------------
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---
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TVINRDGQEEKQVSF
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--------
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G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------