@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0687: (2016-04-24 )
MSARGGSLHGRVAFVTGAARAQGRSHAVRLAREGADIVALDICAPVSGSVTYPPATSEDLGETVRAVEAEGRKVLAREVDIRDDAELRRLVADGVEQFGRLDIVVANAGVLGWGRLWELTDEQWETVIGVNLTGTWRTLRATVPAMIDAGNGGSIVVVSSSAGLKATPGNGHYAASKHALVALTNTLAIELGEFGIRVNSIHPYSVDTPMIEPEAMIQTFAKHPGYVHSFPPMPLQPKGFMTPDEISDVVVWLAGDGSGALSGNQIPVDKGALKY
Atome Classification :
(25 SA)
.........10........20........30........40........50---........60....-....70........80........90........100.......110..-.-....120.-......130.......140.......150.......160....----....170--........180.......190.......200.......210...---...-..---220-...------..------...----.230---.----.......240.......250.......260.......270...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSARGGSLH
G
R
V
A
F
V
TGAARAQG
R
S
H
A
V
R
L
A
REGA
D
I
V
A
L
D
I
CAPVSGSVT---YPPA
T
S
E
D
L
G
E
T
V
R
-
A
V
E
AEG
R
K
V
L
A
R
EVDIR
D
D
A
E
L
R
R
L
V
A
D
G
V
E
Q
FGR
L
D
I
V
V
ANAGVLGW
G
-
R
-
L
W
E
L
T
D
EQ-W
E
T
V
I
G
V
N
L
TGTW
R
T
L
R
ATV
P
A
M
I
DAGNG
G
S
I
V
V
V
SSS-AGLK----ATPGNG---HYAAS
K
H
A
L
V
A
LT
N
T
L
A
I
E
LGEF
G
I
R
VNSIHPYSVDTPMI-
E
P
E
---
A
M
I
-
Q
T
---
F
---
A
KH------PG------YVH----SFP----P----MPLQPKGFM
T
P
D
E
IS
D
V
V
V
W
L
AGDGSGALSGNQIPVDKGALKY
22
PsiBlast_CBE
96.96
80%
-90
- C1 -
3PGX
1
Y4146_MYCPA
C:
[11-280]
-----
G
S
L
Q
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
I
A
C
D
I
C
A
P
V
S
A
S
V
T
---
Y
A
P
A
S
P
E
D
L
D
E
T
A
R
-
L
V
E
D
Q
G
R
K
A
L
T
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
L
S
W
G
-
R
-
V
W
E
L
T
D
E
Q
-
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
L
R
A
T
V
P
A
M
I
E
A
G
N
G
G
S
I
V
V
V
S
S
S
-
A
G
L
K
----
A
T
P
G
N
G
---
H
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
I
H
P
Y
S
V
E
T
P
M
I
-
E
P
E
---
A
M
M
-
E
I
---
F
---
A
R
H
------
P
S
------
F
V
H
----
S
F
P
----
P
----
M
P
V
Q
P
N
G
F
M
T
A
D
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
A
L
K
Y
21
PsiBlast_CBE
94.13
80%
-89
- C1 -
3PGX
1
Y4146_MYCPA
D:
[11-280]
-----
G
S
L
Q
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
I
A
C
D
I
C
A
P
V
S
A
S
V
T
---
Y
A
P
A
S
P
E
D
L
D
E
T
A
R
-
L
V
E
D
Q
G
R
K
A
L
T
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
L
S
W
G
-
R
-
V
W
E
L
T
D
E
Q
-
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
L
R
A
T
V
P
A
M
I
E
A
G
N
G
G
S
I
V
V
V
S
S
S
-
A
G
L
K
----
A
T
P
G
N
G
---
H
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
I
H
P
Y
S
V
E
T
P
M
I
-
E
P
E
---
A
M
M
-
E
I
---
F
---
A
R
H
------
P
S
------
F
V
H
----
S
F
P
----
P
----
M
P
V
Q
P
N
G
F
M
T
A
D
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
A
L
K
Y
23
PsiBlast_CBE
93.75
80%
-88
- C1 -
3PGX
1
Y4146_MYCPA
B:
[11-280]
-----
G
S
L
Q
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
I
A
C
D
I
C
A
P
V
S
A
S
V
T
---
Y
A
P
A
S
P
E
D
L
D
E
T
A
R
-
L
V
E
D
Q
G
R
K
A
L
T
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
L
S
W
G
-
R
-
V
W
E
L
T
D
E
Q
-
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
L
R
A
T
V
P
A
M
I
E
A
G
N
G
G
S
I
V
V
V
S
S
S
-
A
G
L
K
----
A
T
P
G
N
G
---
H
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
I
H
P
Y
S
V
E
T
P
M
I
-
E
P
E
---
A
M
M
-
E
I
---
F
---
A
R
H
------
P
S
------
F
V
H
----
S
F
P
----
P
----
M
P
V
Q
P
N
G
F
M
T
A
D
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
A
L
K
Y
1
PsiBlast_PDB
93.32
80%
-87
- C1 -
3PGX
1
Y4146_MYCPA
A:
[11-280]
-----
G
S
L
Q
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
A
E
G
A
D
I
I
A
C
D
I
C
A
P
V
S
A
S
V
T
---
Y
A
P
A
S
P
E
D
L
D
E
T
A
R
-
L
V
E
D
Q
G
R
K
A
L
T
R
V
L
D
V
R
D
D
A
A
L
R
E
L
V
A
D
G
M
E
Q
F
G
R
L
D
V
V
V
A
N
A
G
V
L
S
W
G
-
R
-
V
W
E
L
T
D
E
Q
-
W
D
T
V
I
G
V
N
L
T
G
T
W
R
T
L
R
A
T
V
P
A
M
I
E
A
G
N
G
G
S
I
V
V
V
S
S
S
-
A
G
L
K
----
A
T
P
G
N
G
---
H
Y
S
A
S
K
H
G
L
T
A
L
T
N
T
L
A
I
E
L
G
E
Y
G
I
R
V
N
S
I
H
P
Y
S
V
E
T
P
M
I
-
E
P
E
---
A
M
M
-
E
I
---
F
---
A
R
H
------
P
S
------
F
V
H
----
S
F
P
----
P
----
M
P
V
Q
P
N
G
F
M
T
A
D
E
V
A
D
V
V
A
W
L
A
G
D
G
S
G
T
L
T
G
T
Q
I
P
V
D
K
G
A
L
K
Y
6
PsiBlast_PDB
81.50
45%
-89
- C1 -
3T7C
1
?
A:
[24-297]
-----
G
K
V
E
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
I
T
L
A
R
E
G
A
D
I
I
A
I
D
V
C
K
Q
L
D
G
-
V
K
---
L
P
M
S
T
P
D
D
L
A
E
T
V
R
-
Q
V
E
A
L
G
R
R
I
I
A
S
Q
V
D
V
R
D
F
D
A
M
Q
A
A
V
D
D
G
V
T
Q
L
G
R
L
D
I
V
L
A
N
A
A
L
A
S
E
G
T
R
-
L
N
R
M
D
P
K
T
-
W
R
D
M
I
D
V
N
L
N
G
A
W
I
T
A
R
V
A
I
P
H
I
M
A
G
K
R
G
G
S
I
V
F
T
S
S
I
-
G
G
L
R
----
G
A
E
N
I
G
---
N
Y
I
A
S
K
H
G
L
H
G
L
M
R
T
M
A
L
E
L
G
P
R
N
I
R
V
N
I
V
C
P
S
S
V
A
T
P
M
L
-
L
N
E
---
P
T
Y
-
R
M
---
F
R
PD
L
E
N
------
P
-------
T
V
E
----
D
F
Q
V
A
S
R
Q
----
M
H
V
L
P
I
P
Y
V
E
P
A
D
I
S
N
A
I
L
F
L
V
S
D
D
A
R
Y
I
T
G
V
S
L
P
V
D
G
G
A
L
--
5
PsiBlast_PDB
81.09
45%
-90
- C1 -
5EJ2
3
?
A:
[33-306]
-----
G
R
V
A
G
K
V
A
F
I
S
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
I
D
I
C
G
P
I
E
-
N
L
A
---
Y
P
H
S
T
P
E
D
L
A
E
T
A
D
-
L
V
K
D
L
D
R
R
I
V
T
A
Q
V
D
V
R
D
F
E
A
L
K
S
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
V
G
T
D
G
-
R
K
L
H
K
I
R
D
N
V
-
W
Q
D
M
I
D
I
N
L
T
G
V
W
H
T
V
K
A
G
V
P
H
V
L
S
G
G
R
G
G
S
I
V
L
T
S
S
V
-
G
G
R
K
----
A
Y
P
N
T
G
---
H
Y
I
A
A
K
H
G
V
I
G
L
M
R
A
F
A
V
E
L
G
P
H
M
I
R
V
N
A
V
L
P
T
Q
V
S
T
T
M
V
-
M
N
D
---
Q
T
F
-
R
L
---
F
R
PD
L
E
N
------
P
G
------
P
-
D
----
D
F
A
----
P
I
S
Q
M
M
H
T
L
P
V
P
W
V
D
A
S
D
I
S
N
A
V
L
F
L
A
S
D
E
S
R
Y
V
T
G
V
S
L
P
V
D
A
G
S
L
--
32
PsiBlast_CBE
80.75
45%
-87
- C1 -
5EJ2
3
?
D:
[33-306]
-----
G
R
V
A
G
K
V
A
F
I
S
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
I
D
I
C
G
P
I
E
-
N
L
A
---
Y
P
H
S
T
P
E
D
L
A
E
T
A
D
-
L
V
K
D
L
D
R
R
I
V
T
A
Q
V
D
V
R
D
F
E
A
L
K
S
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
V
G
T
D
G
-
R
K
L
H
K
I
R
D
N
V
-
W
Q
D
M
I
D
I
N
L
T
G
V
W
H
T
V
K
A
G
V
P
H
V
L
S
G
G
R
G
G
S
I
V
L
T
S
S
V
-
G
G
R
K
----
A
Y
P
N
T
G
---
H
Y
I
A
A
K
H
G
V
I
G
L
M
R
A
F
A
V
E
L
G
P
H
M
I
R
V
N
A
V
L
P
T
Q
V
S
T
T
M
V
-
M
N
D
---
Q
T
F
-
R
L
---
F
RPD
L
E
N
------
P
G
------
P
-
D
----
D
F
A
----
P
ISQM
M
H
T
L
P
V
P
W
V
D
A
S
D
I
S
N
A
V
L
F
L
A
S
D
E
S
R
Y
V
T
G
V
S
L
P
V
D
A
G
S
L
--
34
PsiBlast_CBE
80.12
45%
-89
- C1 -
5EJ2
3
?
B:
[33-306]
-----
G
R
V
A
G
K
V
A
F
I
S
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
I
D
I
C
G
P
I
E
-
N
L
A
---
Y
P
H
S
T
P
E
D
L
A
E
T
A
D
-
L
V
K
D
L
D
R
R
I
V
T
A
Q
V
D
V
R
D
F
E
A
L
K
S
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
V
G
T
D
G
-
R
K
L
H
K
I
R
D
N
V
-
W
Q
D
M
I
D
I
N
L
T
G
V
W
H
T
V
K
A
G
V
P
H
V
L
S
G
G
R
G
G
S
I
V
L
T
S
S
V
-
G
G
R
K
----
A
Y
P
N
T
G
---
H
Y
I
A
A
K
H
G
V
I
G
L
M
R
A
F
A
V
E
L
G
P
H
M
I
R
V
N
A
V
L
P
T
Q
V
S
T
T
M
V
-
M
N
D
---
Q
T
F
-
R
L
---
F
RPD
L
E
N
------
P
G
------
P
-
D
----
D
F
A
----
P
ISQM
M
H
T
L
P
V
P
W
V
D
A
S
D
I
S
N
A
V
L
F
L
A
S
D
E
S
R
Y
V
T
G
V
S
L
P
V
D
A
G
S
L
--
29
PsiBlast_CBE
80.11
45%
-96
- C1 -
3UVE
5
?
D:
[7-284]
-----
G
R
V
E
G
K
V
A
F
V
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
V
D
I
C
K
P
I
R
A
G
V
V
DTA
I
P
A
S
T
P
E
D
L
A
E
T
A
D
-
L
V
K
G
H
N
R
R
I
V
T
A
E
V
D
V
R
D
Y
D
A
L
K
A
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
I
G
N
G
G
-
D
-
T
L
D
K
T
S
E
E
D
W
T
E
M
I
D
I
N
L
A
G
V
W
K
T
V
K
A
G
V
P
H
M
I
A
G
G
R
G
G
S
I
I
L
T
S
S
V
-
G
G
L
K
----
A
Y
P
H
T
G
---
H
Y
V
A
A
K
H
G
V
V
G
L
M
R
A
F
G
V
E
L
G
Q
H
M
I
R
V
N
S
V
H
P
T
H
V
K
T
P
M
L
-
H
N
E
---
G
T
F
-
K
M
---
F
RPD
L
E
N
------
P
G
PDDMAP
I
C
Q
----
M
F
H
----
T
----
L
P
I
P
---
W
V
E
P
I
D
I
S
N
A
V
L
F
F
A
S
D
E
A
R
Y
I
T
G
V
T
L
P
I
D
A
G
S
C
--
37
PsiBlast_CBE
79.94
45%
-90
- C1 -
3T7C
1
?
B:
[24-297]
-----
G
K
V
E
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
I
T
L
A
R
E
G
A
D
I
I
A
I
D
V
C
K
Q
L
D
G
-
V
K
---
L
P
M
S
T
P
D
D
L
A
E
T
V
R
-
Q
V
E
A
L
G
R
R
I
I
A
S
Q
V
D
V
R
D
F
D
A
M
Q
A
A
V
D
D
G
V
T
Q
L
G
R
L
D
I
V
L
A
N
A
A
L
A
S
E
G
T
R
-
L
N
R
M
D
P
K
T
-
W
R
D
M
I
D
V
N
L
N
G
A
W
I
T
A
R
V
A
I
P
H
I
M
A
G
K
R
G
G
S
I
V
F
T
S
S
I
-
G
G
L
R
----
G
A
E
N
I
G
---
N
Y
I
A
S
K
H
G
L
H
G
L
M
R
T
M
A
L
E
L
G
P
R
N
I
R
V
N
I
V
C
P
S
S
V
A
T
P
M
L
-
L
N
E
---
P
T
Y
-
R
M
---
F
R
PD
L
E
N
------
P
-------
T
V
E
----
D
F
Q
V
A
S
R
Q
----
M
H
V
L
P
I
P
Y
V
E
P
A
D
I
S
N
A
I
L
F
L
V
S
D
D
A
R
Y
I
T
G
V
S
L
P
V
D
G
G
A
L
--
33
PsiBlast_CBE
79.86
45%
-86
- C1 -
5EJ2
3
?
C:
[33-306]
-----
G
R
V
A
G
K
V
A
F
I
S
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
I
D
I
C
G
P
I
E
-
N
L
A
---
Y
P
H
S
T
P
E
D
L
A
E
T
A
D
-
L
V
K
D
L
D
R
R
I
V
T
A
Q
V
D
V
R
D
F
E
A
L
K
S
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
V
G
T
D
G
-
R
K
L
H
K
I
R
D
N
V
-
W
Q
D
M
I
D
I
N
L
T
G
V
W
H
T
V
K
A
G
V
P
H
V
L
S
G
G
R
G
G
S
I
V
L
T
S
S
V
-
G
G
R
K
----
A
Y
P
N
T
G
---
H
Y
I
A
A
K
H
G
V
I
G
L
M
R
A
F
A
V
E
L
G
P
H
M
I
R
V
N
A
V
L
P
T
Q
V
S
T
T
M
V
-
M
N
D
---
Q
T
F
-
R
L
---
F
RPD
L
E
N
------
P
G
------
P
-
D
----
D
F
A
----
P
ISQM
M
H
T
L
P
V
P
W
V
D
A
S
D
I
S
N
A
V
L
F
L
A
S
D
E
S
R
Y
V
T
G
V
S
L
P
V
D
A
G
S
L
--
31
PsiBlast_CBE
79.74
45%
-95
- C1 -
3UVE
6
?
B:
[7-284]
-----
G
R
V
E
G
K
V
A
F
V
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
V
D
I
C
K
P
I
R
A
G
V
V
DTA
I
P
A
S
T
P
E
D
L
A
E
T
A
D
-
L
V
K
G
H
N
R
R
I
V
T
A
E
V
D
V
R
D
Y
D
A
L
K
A
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
I
G
N
G
G
-
D
-
T
L
D
K
T
S
E
E
D
W
T
E
M
I
D
I
N
L
A
G
V
W
K
T
V
K
A
G
V
P
H
M
I
A
G
G
R
G
G
S
I
I
L
T
S
S
V
-
G
G
L
K
----
A
Y
P
H
T
G
---
H
Y
V
A
A
K
H
G
V
V
G
L
M
R
A
F
G
V
E
L
G
Q
H
M
I
R
V
N
S
V
H
P
T
H
V
K
T
P
M
L
-
H
N
E
---
G
T
F
-
K
M
---
F
RPD
L
E
N
------
P
G
PDDMAP
I
C
Q
----
M
F
H
----
T
----
L
P
I
P
---
W
V
E
P
I
D
I
S
N
A
V
L
F
F
A
S
D
E
A
R
Y
I
T
G
V
T
L
P
I
D
A
G
S
C
--
35
PsiBlast_CBE
79.63
45%
-88
- C1 -
3T7C
1
?
D:
[24-297]
-----
G
K
V
E
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
I
T
L
A
R
E
G
A
D
I
I
A
I
D
V
C
K
Q
L
D
G
-
V
K
---
L
P
M
S
T
P
D
D
L
A
E
T
V
R
-
Q
V
E
A
L
G
R
R
I
I
A
S
Q
V
D
V
R
D
F
D
A
M
Q
A
A
V
D
D
G
V
T
Q
L
G
R
L
D
I
V
L
A
N
A
A
L
A
S
E
G
T
R
-
L
N
R
M
D
P
K
T
-
W
R
D
M
I
D
V
N
L
N
G
A
W
I
T
A
R
V
A
I
P
H
I
M
A
G
K
R
G
G
S
I
V
F
T
S
S
I
-
G
G
L
R
----
G
A
E
N
I
G
---
N
Y
I
A
S
K
H
G
L
H
G
L
M
R
T
M
A
L
E
L
G
P
R
N
I
R
V
N
I
V
C
P
S
S
V
A
T
P
M
L
-
L
N
E
---
P
T
Y
-
R
M
---
F
R-----------
P
-------
T
V
E
----
D
F
Q
VASR
Q
----
M
H
V
L
P
I
P
Y
V
E
P
A
D
I
S
N
A
I
L
F
L
V
S
D
D
A
R
Y
I
T
G
V
S
L
P
V
D
G
G
A
L
--
24
PsiBlast_CBE
79.25
48%
-83
- C1 -
3TSC
1
?
D:
[7-277]
-----
G
K
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
G
K
L
P
S
C
V
P
---
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
-
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
A
A
P
Q
-
A
-
W
D
D
I
T
P
E
D
-
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
-
A
G
M
K
----
M
Q
P
F
M
I
---
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
N
T
P
M
G
-
S
G
D
MVT
A
V
G
-
Q
A
---
M
---
E
T
N
------
P
Q
------
L
S
H
----
V
L
----------
T
P
F
L
P
D
W
V
A
E
P
E
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
S
T
Q
Y
25
PsiBlast_CBE
78.96
48%
-85
- C1 -
3TSC
3
?
C:
[7-277]
-----
G
K
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
G
K
L
P
S
C
V
P
---
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
-
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
A
A
P
Q
-
A
-
W
D
D
I
T
P
E
D
-
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
-
A
G
M
K
----
M
Q
P
F
M
I
---
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
N
T
P
M
G
-
S
G
D
MVT
A
V
G
-
Q
A
---
M
---
E
T
N
------
P
Q
------
L
S
H
----
V
L
----------
T
P
F
L
P
D
W
V
A
E
P
E
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
S
T
Q
Y
30
PsiBlast_CBE
78.71
45%
-95
- C1 -
3UVE
4
?
C:
[7-284]
-----
G
R
V
E
G
K
V
A
F
V
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
V
D
I
C
K
P
I
R
A
G
V
V
DTA
I
P
A
S
T
P
E
D
L
A
E
T
A
D
-
L
V
K
G
H
N
R
R
I
V
T
A
E
V
D
V
R
D
Y
D
A
L
K
A
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
I
G
N
G
G
-
D
-
T
L
D
K
T
S
E
E
D
W
T
E
M
I
D
I
N
L
A
G
V
W
K
T
V
K
A
G
V
P
H
M
I
A
G
G
R
G
G
S
I
I
L
T
S
S
V
-
G
G
L
K
----
A
Y
P
H
T
G
---
H
Y
V
A
A
K
H
G
V
V
G
L
M
R
A
F
G
V
E
L
G
Q
H
M
I
R
V
N
S
V
H
P
T
H
V
K
T
P
M
L
-
H
N
E
---
G
T
F
-
K
M
---
F
RPD
L
E
N
------
P
G
PDDMAP
I
C
Q
----
M
F
H
----
T
----
L
P
I
P
---
W
V
E
P
I
D
I
S
N
A
V
L
F
F
A
S
D
E
A
R
Y
I
T
G
V
T
L
P
I
D
A
G
S
C
--
4
PsiBlast_PDB
78.24
45%
-96
- C1 -
3UVE
4
?
A:
[7-284]
-----
G
R
V
E
G
K
V
A
F
V
T
G
A
A
R
G
Q
G
R
S
H
A
V
R
L
A
Q
E
G
A
D
I
I
A
V
D
I
C
K
P
I
R
A
G
V
V
DTA
I
P
A
S
T
P
E
D
L
A
E
T
A
D
-
L
V
K
G
H
N
R
R
I
V
T
A
E
V
D
V
R
D
Y
D
A
L
K
A
A
V
D
S
G
V
E
Q
L
G
R
L
D
I
I
V
A
N
A
G
I
G
N
G
G
-
D
-
T
L
D
K
T
S
E
E
D
W
T
E
M
I
D
I
N
L
A
G
V
W
K
T
V
K
A
G
V
P
H
M
I
A
G
G
R
G
G
S
I
I
L
T
S
S
V
-
G
G
L
K
----
A
Y
P
H
T
G
---
H
Y
V
A
A
K
H
G
V
V
G
L
M
R
A
F
G
V
E
L
G
Q
H
M
I
R
V
N
S
V
H
P
T
H
V
K
T
P
M
L
-
H
N
E
---
G
T
F
-
K
M
---
F
R
PD
L
E
N
------
P
G
PDDM
A
P
I
C
Q
----
M
F
H
----
T
----
L
P
I
P
---
W
V
E
P
I
D
I
S
N
A
V
L
F
F
A
S
D
E
A
R
Y
I
T
G
V
T
L
P
I
D
A
G
S
C
--
36
PsiBlast_CBE
77.97
45%
-92
- C1 -
3T7C
1
?
C:
[24-297]
-----
G
K
V
E
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
I
T
L
A
R
E
G
A
D
I
I
A
I
D
V
C
K
Q
L
D
G
-
V
K
---
L
P
M
S
T
P
D
D
L
A
E
T
V
R
-
Q
V
E
A
L
G
R
R
I
I
A
S
Q
V
D
V
R
D
F
D
A
M
Q
A
A
V
D
D
G
V
T
Q
L
G
R
L
D
I
V
L
A
N
A
A
L
A
S
E
G
T
R
-
L
N
R
M
D
P
K
T
-
W
R
D
M
I
D
V
N
L
N
G
A
W
I
T
A
R
V
A
I
P
H
I
M
A
G
K
R
G
G
S
I
V
F
T
S
S
I
-
G
G
L
R
----
G
A
E
N
I
G
---
N
Y
I
A
S
K
H
G
L
H
G
L
M
R
T
M
A
L
E
L
G
P
R
N
I
R
V
N
I
V
C
P
S
S
V
A
T
P
M
L
-
L
N
E
---
P
T
Y
-
R
M
---
F
RPD
L
E
N
------
P
-------
T
V
E
----
D
F
Q
VASR
Q
----
M
H
V
L
P
I
P
Y
V
E
P
A
D
I
S
N
A
I
L
F
L
V
S
D
D
A
R
Y
I
T
G
V
S
L
P
V
D
G
G
A
L
--
26
PsiBlast_CBE
77.95
48%
-84
- C1 -
3TSC
1
?
B:
[7-277]
-----
G
K
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
G
K
L
P
S
C
V
P
---
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
-
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
A
A
P
Q
-
A
-
W
D
D
I
T
P
E
D
-
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
-
A
G
M
K
----
M
Q
P
F
M
I
---
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
N
T
P
M
G
-
S
G
D
MVT
A
V
G
-
Q
A
---
M
---
E
T
N
------
P
Q
------
L
S
H
----
V
L
----------
T
P
F
L
P
D
W
V
A
E
P
E
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
S
T
Q
Y
28
PsiBlast_CBE
77.79
44%
-85
- C1 -
3OEC
1
?
C:
[42-314]
-----
N
R
L
Q
G
K
V
A
F
I
T
G
A
A
R
G
Q
G
R
T
H
A
V
R
L
A
Q
D
G
A
D
I
V
A
I
D
L
C
R
Q
---
N
L
D
---
Y
A
Q
G
S
P
E
E
L
K
E
T
V
R
-
L
V
E
E
Q
G
R
R
I
I
A
R
Q
A
D
V
R
D
L
A
S
L
Q
A
V
V
D
E
A
L
A
E
F
G
H
I
D
I
L
V
S
N
V
G
I
S
N
Q
G
-
E
-
V
V
S
L
T
D
Q
Q
-
W
S
D
I
L
Q
T
N
L
I
G
A
W
H
A
C
R
A
V
L
P
S
M
I
E
R
G
Q
G
G
S
V
I
F
V
S
S
T
-
V
G
L
R
----
G
A
P
G
Q
S
---
H
Y
A
A
S
K
H
G
V
Q
G
L
M
L
S
L
A
N
E
V
G
R
H
N
I
R
V
N
S
V
N
P
G
A
V
N
T
E
M
A
-
L
N
E
---
K
L
L
-
K
M
---
F
---
L
P
H
LENPT
R
E
D
------
A
A
E
----
L
F
S
----
Q
----
L
T
L
L
P
I
P
W
V
E
P
E
D
V
S
N
A
V
A
W
L
A
S
D
E
A
R
Y
I
H
G
A
A
I
P
V
D
G
G
Q
L
--
2
PsiBlast_PDB
77.06
48%
-83
- C1 -
3TSC
1
?
A:
[7-277]
-----
G
K
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
G
K
L
P
S
C
V
P
---
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
-
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
A
A
P
Q
-
A
-
W
D
D
I
T
P
E
D
-
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
-
A
G
M
K
----
M
Q
P
F
M
I
---
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
N
T
P
M
G
-
S
G
D
M
V
T
A
V
G
-
Q
A
---
M
---
E
T
N
------
P
Q
------
L
S
H
----
V
L
----------
T
P
F
L
P
D
W
V
A
E
P
E
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
S
T
Q
Y
106
HHSearch
72.62
46%
-81
- C1 -
3TSC
1
?
A:
[7-277]
-----
G
K
L
E
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
G
K
L
P
S
C
V
P
---
Y
D
P
A
S
P
D
D
-
L
S
E
T
V
R
L
V
E
A
A
N
R
R
I
V
A
A
V
V
D
T
R
D
F
D
R
L
R
K
V
V
D
D
G
V
A
A
L
G
R
L
D
I
I
V
A
N
A
G
V
A
A
P
Q
-
A
-
W
D
D
I
T
P
E
D
-
F
R
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
G
G
S
I
I
L
I
S
S
A
-
A
G
M
K
----
M
Q
P
F
M
I
---
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
H
S
I
R
V
N
S
V
H
P
G
P
V
N
T
P
M
G
-
S
G
D
---
M
V
T
-
A
V
G
Q
A
M
---
E
T
N
------
P
Q
------
L
S
H
----
V
L
T
----
P
----
F
L
P
D
W
--
V
A
E
P
E
D
I
A
D
T
V
C
W
L
A
S
D
E
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
S
T
Q
Y
8
PsiBlast_PDB
71.54
38%
-91
- C1 -
4RGB
1
?
A:
[21-289]
-----
G
S
L
D
G
R
V
V
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
M
C
A
E
Q
G
A
N
I
V
G
V
D
I
C
E
D
I
D
-
I
V
P
---
Y
K
L
G
T
Y
E
E
L
E
E
T
A
R
-
L
V
E
K
T
G
Q
E
M
L
F
R
K
A
D
V
R
D
K
A
V
L
Q
E
V
F
D
A
G
V
E
Q
F
G
H
I
D
T
V
I
A
N
A
G
V
V
L
T
N
-
P
-
D
E
R
D
A
S
E
A
-
L
R
L
G
L
D
I
M
L
I
G
V
W
N
T
F
Q
V
A
I
P
H
M
K
E
R
G
Q
G
G
N
L
I
A
T
S
S
M
I
A
L
L
D
----
L
T
D
G
R
G
G
T
D
A
Y
L
T
S
K
L
A
I
T
G
L
V
R
S
Y
A
L
M
L
A
A
D
R
I
R
V
N
G
V
A
P
T
N
C
S
T
P
M
I
T
E
N
P
---
A
L
F
-
K
V
---
I
---
E
E
N
------
P
H
------
L
V
N
AMST
A
L
P
----
D
----
F
P
M
-----
I
E
P
R
D
V
S
N
A
I
L
F
L
I
S
D
A
G
R
S
F
T
G
S
V
L
K
V
D
A
G
----
49
PsiBlast_CBE
71.45
38%
-90
- C1 -
4RGB
1
?
B:
[21-289]
-----
G
S
L
D
G
R
V
V
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
M
C
A
E
Q
G
A
N
I
V
G
V
D
I
C
E
D
I
D
-
I
V
P
---
Y
K
L
G
T
Y
E
E
L
E
E
T
A
R
-
L
V
E
K
T
G
Q
E
M
L
F
R
K
A
D
V
R
D
K
A
V
L
Q
E
V
F
D
A
G
V
E
Q
F
G
H
I
D
T
V
I
A
N
A
G
V
V
L
T
N
-
P
-
D
E
R
D
A
S
E
A
-
L
R
L
G
L
D
I
M
L
I
G
V
W
N
T
F
Q
V
A
I
P
H
M
K
E
R
G
Q
G
G
N
L
I
A
T
S
S
M
I
A
L
L
D
----
L
T
D
G
R
G
GTD
A
Y
L
T
S
K
L
A
I
T
G
L
V
R
S
Y
A
L
M
L
A
A
D
R
I
R
V
N
G
V
A
P
T
N
C
S
T
P
M
I
T
E
N
P
---
A
L
F
-
K
V
---
I
---
E
E
N
------
P
H
------
L
V
N
AMST
A
L
P
----
D
----
F
P
M
-----
I
E
P
R
D
V
S
N
A
I
L
F
L
I
S
D
A
G
R
S
F
T
G
S
V
L
K
V
D
A
G
----
105
HHSearch
62.46
36%
-84
- C1 -
4RGB
1
?
A:
[21-291]
-----
G
S
L
D
G
R
V
V
F
I
T
G
A
A
R
G
Q
G
R
S
H
A
V
M
C
A
E
Q
G
A
N
I
V
G
V
D
I
C
E
D
I
D
I
-
V
P
---
Y
K
L
G
T
Y
E
E
-
L
E
E
T
A
R
L
V
E
K
T
G
Q
E
M
L
F
R
K
A
D
V
R
D
K
A
V
L
Q
E
V
F
D
A
G
V
E
Q
F
G
H
I
D
T
V
I
A
N
A
G
V
V
L
T
N
-
P
-
D
E
R
D
A
S
E
A
-
L
R
L
G
L
D
I
M
L
I
G
V
W
N
T
F
Q
V
A
I
P
H
M
K
E
R
G
Q
G
G
N
L
I
A
T
S
S
M
-
I
A
L
L
DLTD
G
R
G
G
T
D
---
A
Y
L
T
S
K
L
A
I
T
G
L
V
R
S
Y
A
L
M
L
A
A
D
R
I
R
V
N
G
V
A
P
T
N
C
S
T
P
M
I
-
T
E
N
---
P
A
L
F
K
V
---
I
---
E
E
N
------
P
H
------
L
V
N
----
A
M
S
T---
A
----
L
P
D
F
P
--
M
I
E
P
R
D
V
S
N
A
I
L
F
L
I
S
D
A
G
R
S
F
T
G
S
V
L
K
V
D
A
G
M
D
--